Best TWAS P=4.72e-15 · Best GWAS P=6.93e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HAUS8 | 0.11 | 0.09 | lasso | 3 | 0.08 | 5.4e-07 | 5.9 | -6.2 | 6.0e-10 | -0.62 | 0.32 | 0.67 | FALSE |
| 2 | GTEx | Artery Aorta | HAUS8 | 0.18 | 0.12 | lasso | 2 | 0.09 | 7.3e-06 | 5.7 | -5.8 | 6.3e-09 | -0.63 | 0.37 | 0.58 | FALSE |
| 3 | GTEx | Artery Tibial | HAUS8 | 0.16 | 0.02 | lasso | 7 | 0.02 | 4.7e-03 | 5.7 | -6.5 | 8.3e-11 | -0.62 | 0.22 | 0.70 | FALSE |
| 4 | GTEx | Artery Tibial | CTD-3032J10.3 | 0.14 | 0.01 | lasso | 5 | 0.01 | 6.4e-02 | 8.3 | -7.8 | 4.7e-15 | -0.96 | 0.00 | 0.96 | TRUE |
| 5 | GTEx | Brain Cerebellar Hemisphere | HAUS8 | 0.44 | 0.15 | lasso | 7 | 0.11 | 8.1e-04 | 5.9 | -6.0 | 2.5e-09 | -0.57 | 0.24 | 0.17 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | HAUS8 | 0.12 | 0.05 | enet | 19 | 0.05 | 1.0e-04 | 5.7 | -6.2 | 4.7e-10 | -0.53 | 0.62 | 0.19 | FALSE |
| 7 | GTEx | Esophagus Muscularis | MYO9B | 0.13 | 0.02 | lasso | 5 | 0.05 | 9.5e-04 | 4.0 | -7.1 | 1.4e-12 | -0.62 | 0.03 | 0.95 | FALSE |
| 8 | GTEx | Esophagus Muscularis | HAUS8 | 0.20 | 0.11 | lasso | 4 | 0.09 | 5.1e-06 | 5.9 | -5.9 | 4.8e-09 | -0.59 | 0.67 | 0.16 | FALSE |
| 9 | GTEx | Muscle Skeletal | HAUS8 | 0.15 | 0.10 | lasso | 4 | 0.08 | 1.6e-08 | 5.7 | -6.1 | 9.6e-10 | -0.62 | 1.00 | 0.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | HAUS8 | 0.05 | 0.05 | enet | 7 | 0.05 | 7.1e-07 | 5.8 | -5.8 | 7.2e-09 | -0.63 | 0.74 | 0.24 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HAUS8 | 0.05 | 0.06 | enet | 12 | 0.06 | 2.9e-12 | 5.7 | -6.3 | 2.6e-10 | -0.57 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | HAUS8 | 0.10 | 0.07 | blup | 55 | 0.07 | 3.2e-04 | 5.7 | -5.6 | 1.8e-08 | -0.74 | 0.04 | 0.93 | FALSE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | HAUS8 | 0.12 | 0.06 | lasso | 5 | 0.06 | 1.8e-04 | 5.7 | -6.1 | 1.4e-09 | -0.58 | 0.42 | 0.26 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HAUS8 | 0.08 | 0.07 | blup | 55 | 0.07 | 6.7e-08 | 5.7 | -6.4 | 1.2e-10 | -0.53 | 1.00 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HAUS8 | 0.09 | 0.14 | lasso | 4 | 0.12 | 5.9e-14 | 5.9 | -6.1 | 1.3e-09 | -0.65 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | HAUS8 | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.6e-04 | 5.7 | -5.4 | 6.3e-08 | -0.57 | 0.56 | 0.04 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | HAUS8 | 0.06 | 0.04 | enet | 4 | 0.05 | 3.9e-06 | 4.0 | -5.2 | 2.0e-07 | -0.54 | 0.91 | 0.01 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HAUS8 | 0.20 | 0.13 | lasso | 2 | 0.11 | 2.4e-05 | 5.7 | -6.0 | 2.1e-09 | -0.61 | 0.50 | 0.06 | FALSE |
| 19 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | HAUS8 | 0.21 | 0.11 | enet | 9 | 0.10 | 6.2e-05 | -5.7 | -6.2 | 6.8e-10 | -0.56 | 0.10 | 0.46 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HAUS8 | 0.13 | 0.10 | blup | 55 | 0.11 | 7.8e-12 | 5.7 | -6.0 | 2.4e-09 | -0.49 | 1.00 | 0.00 | FALSE |
| 21 | The Cancer Genome Atlas | Stomach Adenocarcinoma | HAUS8 | 0.06 | 0.04 | blup | 55 | 0.04 | 1.0e-03 | 5.9 | -6.6 | 5.0e-11 | -0.64 | 0.05 | 0.30 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | HAUS8 | 0.04 | 0.06 | lasso | 2 | 0.05 | 2.2e-05 | 5.7 | -6.1 | 8.1e-10 | -0.69 | 0.15 | 0.81 | FALSE |