Best TWAS P=1.59e-18 · Best GWAS P=5.65e-19 conditioned to 5.12e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | S1PR2 | 0.07 | 0.02 | bslmm | 369 | 0.03 | 5.3e-05 | 5.7 | -7.0 | 1.8e-12 | -0.58 | 0.03 | 0.92 | TRUE |
| 2 | GTEx | Adipose Visceral Omentum | S1PR2 | 0.23 | 0.01 | lasso | 5 | 0.01 | 1.1e-01 | 8.9 | -5.2 | 2.4e-07 | -0.77 | 0.01 | 0.92 | FALSE |
| 3 | GTEx | Colon Transverse | SMARCA4 | 0.21 | -0.01 | enet | 21 | 0.00 | 1.8e-01 | -2.8 | 6.2 | 6.4e-10 | -0.01 | 0.06 | 0.05 | TRUE |
| 4 | GTEx | Esophagus Muscularis | KANK2 | 0.16 | 0.05 | enet | 21 | 0.04 | 3.2e-03 | -4.6 | -6.4 | 1.7e-10 | -0.03 | 0.16 | 0.32 | TRUE |
| 5 | GTEx | Testis | ZNF443 | 0.25 | 0.15 | lasso | 3 | 0.14 | 1.2e-06 | -5.3 | 5.6 | 2.4e-08 | 0.04 | 0.01 | 0.99 | TRUE |
| 6 | GTEx | Thyroid | DOCK6 | 0.10 | 0.04 | lasso | 4 | 0.04 | 3.4e-04 | 4.9 | 5.2 | 2.1e-07 | 0.00 | 0.60 | 0.05 | TRUE |
| 7 | NTR | Blood | KANK2 | 0.10 | 0.04 | bslmm | 389 | 0.05 | 2.7e-15 | 8.2 | -6.0 | 1.6e-09 | 0.01 | 0.00 | 1.00 | FALSE |
| 8 | YFS | Blood | KANK2 | 0.05 | 0.02 | bslmm | 384 | 0.03 | 8.6e-09 | 8.2 | -8.8 | 1.6e-18 | -0.01 | 0.00 | 1.00 | TRUE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | ZNF443 | 0.09 | 0.11 | enet | 8 | 0.08 | 1.7e-05 | -5.3 | -5.3 | 1.2e-07 | -0.04 | 0.00 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF709 | 0.02 | 0.02 | blup | 56 | 0.01 | 9.8e-03 | -5.0 | -5.3 | 1.0e-07 | -0.03 | 0.01 | 0.88 | FALSE |