Best TWAS P=8e-14 · Best GWAS P=5.03e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RERE | 0.20 | 0.23 | lasso | 2 | 0.24 | 1.7e-19 | 7.1 | 7.5 | 8.0e-14 | 0.98 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | RP5-1115A15.1 | 0.14 | 0.07 | enet | 20 | 0.10 | 2.6e-08 | -6.4 | 7.0 | 1.7e-12 | 0.80 | 0.06 | 0.94 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | RERE | 0.22 | 0.17 | lasso | 5 | 0.17 | 5.2e-09 | -6.3 | 6.1 | 8.8e-10 | 0.62 | 0.24 | 0.76 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | RERE | 0.19 | 0.08 | enet | 10 | 0.14 | 8.0e-08 | 7.2 | 6.6 | 5.0e-11 | 0.82 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | RP5-1115A15.1 | 0.10 | 0.07 | lasso | 2 | 0.03 | 7.0e-03 | 7.1 | 7.1 | 9.3e-13 | 1.00 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Male) | RP5-1115A15.1 | 0.18 | 0.07 | lasso | 3 | 0.06 | 1.7e-02 | -2.8 | 5.7 | 1.1e-08 | 0.76 | 0.02 | 0.60 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | RERE | 0.12 | 0.08 | lasso | 4 | 0.05 | 6.0e-05 | 7.2 | 7.2 | 4.4e-13 | 0.98 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Esophagus Mucosa | RERE | 0.13 | 0.16 | lasso | 3 | 0.16 | 7.2e-11 | -6.3 | 6.3 | 2.7e-10 | 0.63 | 0.69 | 0.31 | FALSE |
| 9 | GTEx | Esophagus Mucosa | RP5-1115A15.1 | 0.06 | 0.06 | lasso | 4 | 0.05 | 3.0e-04 | -6.3 | 6.4 | 2.0e-10 | 0.67 | 0.06 | 0.84 | FALSE |
| 10 | GTEx | Lung | RERE | 0.07 | 0.05 | lasso | 4 | 0.05 | 2.0e-04 | -5.4 | 5.6 | 2.5e-08 | 0.56 | 0.59 | 0.34 | FALSE |
| 11 | GTEx | Lung | RP5-1115A15.1 | 0.05 | 0.08 | lasso | 1 | 0.07 | 1.0e-05 | -6.4 | 6.4 | 1.3e-10 | 0.64 | 0.24 | 0.60 | FALSE |
| 12 | GTEx | Nerve Tibial | RERE | 0.12 | 0.09 | enet | 16 | 0.11 | 5.6e-08 | 6.7 | 7.0 | 3.4e-12 | 0.92 | 0.01 | 0.99 | FALSE |
| 13 | GTEx | Pancreas | RERE | 0.11 | 0.12 | lasso | 4 | 0.07 | 5.9e-04 | 7.1 | 7.2 | 5.4e-13 | 0.97 | 0.01 | 0.96 | FALSE |
| 14 | GTEx | Skin Not Sun Exposed Suprapubic | RP5-1115A15.1 | 0.08 | 0.04 | enet | 8 | 0.04 | 3.0e-03 | -5.4 | 5.8 | 6.8e-09 | 0.57 | 0.39 | 0.08 | FALSE |
| 15 | GTEx | Skin Sun Exposed Lower leg | RP5-1115A15.1 | 0.07 | 0.03 | enet | 13 | 0.03 | 1.5e-03 | -6.3 | 5.2 | 1.6e-07 | 0.54 | 0.34 | 0.46 | FALSE |
| 16 | GTEx | Thyroid | RP5-1115A15.1 | 0.09 | 0.12 | lasso | 2 | 0.09 | 1.5e-07 | -6.4 | 6.4 | 1.4e-10 | 0.68 | 0.56 | 0.44 | FALSE |
| 17 | GTEx | Whole Blood | RERE | 0.19 | 0.15 | lasso | 4 | 0.13 | 2.7e-12 | -6.3 | 6.6 | 4.6e-11 | 0.68 | 0.69 | 0.31 | FALSE |
| 18 | METSIM | Adipose | RERE | 0.08 | 0.12 | lasso | 17 | 0.13 | 1.8e-19 | 7.1 | 7.1 | 1.1e-12 | 0.89 | 0.01 | 0.99 | FALSE |
| 19 | NTR | Blood | RERE | 0.04 | 0.04 | lasso | 8 | 0.03 | 2.0e-11 | -5.4 | 6.0 | 2.5e-09 | 0.66 | 0.98 | 0.02 | FALSE |
| 20 | ROSMAP | Brain Pre-frontal Cortex | RERE | 0.15 | 0.15 | lasso | 7 | 0.15 | 1.5e-18 | 7.1 | 7.3 | 3.4e-13 | 0.97 | 0.01 | 0.99 | FALSE |
| 21 | YFS | Blood | RERE | 0.09 | 0.15 | lasso | 4 | 0.16 | 5.7e-49 | -6.3 | 6.7 | 1.9e-11 | 0.73 | 0.65 | 0.35 | FALSE |
| 22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RERE | 0.02 | 0.03 | lasso | 2 | 0.03 | 4.7e-07 | -6.3 | 6.2 | 4.7e-10 | 0.62 | 0.61 | 0.35 | FALSE |
| 23 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RERE | 0.22 | 0.04 | lasso | 10 | 0.08 | 4.1e-04 | -6.3 | 7.2 | 4.0e-13 | 0.85 | 0.02 | 0.94 | FALSE |