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chr1:10,435,170-12,731,572

Best TWAS P=1.24e-95 · Best GWAS P=4.87e-87 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CLCN6	0.14	0.05	enet	36	0.08	1.9e-09	4.32	-8.7	2.5e-18	0.20	0.48	0.09	TRUE
2	CommonMind	Brain Pre-frontal Cortex	MTHFR	0.08	0.08	lasso	3	0.07	9.6e-09	-9.76	-9.8	1.7e-22	0.35	1.00	0.00	FALSE
3	GTEx	Artery Aorta	NPPA-AS1	0.11	0.09	enet	7	0.07	6.9e-05	-5.81	5.5	4.1e-08	-0.22	0.73	0.02	FALSE
4	GTEx	Artery Tibial	CLCN6	0.14	0.04	lasso	6	0.04	5.0e-04	-14.06	-12.4	1.4e-35	0.66	0.10	0.89	FALSE
5	GTEx	Brain Cerebellar Hemisphere	NPPA-AS1	0.50	0.17	lasso	5	0.31	1.1e-08	-5.79	8.4	5.9e-17	-0.26	0.86	0.04	FALSE
6	GTEx	Brain Cerebellum	MTHFR	0.25	0.09	lasso	4	0.03	3.5e-02	-9.76	-10.2	2.6e-24	0.34	0.15	0.10	FALSE
7	GTEx	Brain Cerebellum	NPPA-AS1	0.75	0.06	lasso	17	0.13	1.2e-04	-5.79	8.1	4.1e-16	-0.27	0.70	0.03	FALSE
8	GTEx	Brain Hypothalamus	NPPA-AS1	0.37	0.12	enet	40	0.25	1.1e-06	-4.50	6.5	9.2e-11	-0.27	0.18	0.22	FALSE
9	GTEx	Breast Mammary Tissue	NPPA-AS1	0.25	0.01	lasso	4	0.02	3.0e-02	3.65	6.3	3.5e-10	-0.13	0.47	0.05	FALSE
10	GTEx	Breast Mammary Tissue (Male)	FBXO6	0.39	0.01	lasso	6	0.07	1.1e-02	4.25	9.4	3.6e-21	-0.42	0.04	0.47	FALSE
11	GTEx	Breast Mammary Tissue (Female)	NPPA-AS1	0.16	0.01	lasso	3	0.00	3.4e-01	3.65	5.8	7.7e-09	-0.06	0.07	0.09	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	MTHFR	0.33	0.12	lasso	6	0.09	7.9e-04	-13.42	-13.4	4.5e-41	0.80	0.33	0.28	FALSE
13	GTEx	Cells Transformed fibroblasts	CLCN6	0.08	0.02	enet	17	0.05	1.6e-04	-19.78	-16.1	1.6e-58	0.75	0.00	1.00	FALSE
14	GTEx	Cells Transformed fibroblasts	MTHFR	0.13	0.03	enet	30	0.05	6.8e-05	-14.58	-16.3	4.6e-60	0.57	0.04	0.94	FALSE
15	GTEx	Cells Transformed fibroblasts	NPPA-AS1	0.11	0.09	lasso	4	0.08	1.9e-06	-5.81	5.9	4.1e-09	-0.24	0.86	0.01	FALSE
16	GTEx	Esophagus Mucosa	NPPA-AS1	0.14	0.05	enet	13	0.04	7.5e-04	-4.50	7.5	8.1e-14	-0.25	0.84	0.02	FALSE
17	GTEx	Esophagus Muscularis	CLCN6	0.13	0.03	enet	21	0.07	3.6e-05	-10.58	-6.6	3.5e-11	0.44	0.16	0.68	FALSE
18	GTEx	Nerve Tibial	NPPA-AS1	0.11	0.07	lasso	7	0.06	3.4e-05	-5.81	9.1	9.4e-20	-0.32	0.90	0.01	FALSE
19	GTEx	Pituitary	NPPA-AS1	0.70	0.52	enet	10	0.50	1.3e-14	-4.51	5.3	1.2e-07	-0.27	1.00	0.00	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	CLCN6	0.12	0.03	lasso	3	0.04	3.3e-03	-10.92	-16.6	3.2e-62	0.83	0.02	0.94	FALSE
21	GTEx	Skin Sun Exposed Lower leg	CLCN6	0.08	0.00	lasso	3	0.01	7.9e-02	-10.58	-13.9	3.9e-44	0.67	0.02	0.77	FALSE
22	GTEx	Spleen	CLCN6	0.21	0.10	lasso	3	0.06	1.3e-02	-13.43	-15.6	9.2e-55	0.86	0.04	0.67	FALSE
23	GTEx	Spleen	NPPA-AS1	0.48	0.36	lasso	7	0.32	4.1e-09	-5.79	6.0	2.4e-09	-0.22	0.90	0.01	FALSE
24	GTEx	Stomach	RP4-635E18.7	0.13	0.06	enet	25	0.03	8.8e-03	-3.07	-7.6	2.6e-14	0.13	0.12	0.58	TRUE
25	GTEx	Stomach	NPPA-AS1	0.25	0.20	lasso	6	0.23	2.8e-11	-4.50	7.4	1.2e-13	-0.24	1.00	0.00	FALSE
26	GTEx	Testis	CLCN6	0.39	0.17	lasso	10	0.19	1.1e-08	-5.79	8.5	1.4e-17	-0.34	0.99	0.00	FALSE
27	GTEx	Testis	NPPA	0.36	0.23	lasso	9	0.24	5.0e-11	-4.51	8.5	2.6e-17	-0.36	1.00	0.00	TRUE
28	GTEx	Testis	NPPA-AS1	0.62	0.35	lasso	10	0.41	1.8e-19	-5.79	6.8	1.1e-11	-0.28	1.00	0.00	FALSE
29	GTEx	Whole Blood	CLCN6	0.10	0.02	lasso	3	0.04	2.1e-04	-14.06	-7.1	1.1e-12	0.47	0.36	0.06	FALSE
30	METSIM	Adipose	CLCN6	0.09	0.04	blup	480	0.06	1.6e-09	-12.56	-14.2	1.2e-45	0.65	0.06	0.94	FALSE
31	METSIM	Adipose	DRAXIN	0.09	0.01	enet	21	0.04	1.6e-06	-0.87	9.7	2.6e-22	-0.51	0.03	0.92	FALSE
32	METSIM	Adipose	NPPA	0.12	0.09	lasso	11	0.10	3.0e-14	-6.46	6.4	1.7e-10	-0.18	1.00	0.00	TRUE
33	NTR	Blood	AGTRAP	0.02	0.00	bslmm	484	0.00	5.2e-02	0.17	10.9	9.7e-28	-0.38	0.05	0.06	FALSE
34	NTR	Blood	CLCN6	0.01	0.01	lasso	2	0.01	3.0e-04	-14.06	-11.7	1.3e-31	0.78	0.38	0.53	FALSE
35	NTR	Blood	MTHFR	0.09	0.07	enet	17	0.10	4.4e-31	-9.76	-15.3	1.0e-52	0.66	1.00	0.00	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	CLCN6	0.06	0.00	bslmm	467	0.02	9.9e-04	-4.50	-6.0	2.2e-09	0.41	0.16	0.10	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	PLOD1	0.11	0.03	blup	459	0.05	1.3e-07	-3.69	-7.8	9.5e-15	0.42	0.96	0.02	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	NPPA	0.09	0.06	enet	29	0.09	1.2e-11	7.73	7.5	5.5e-14	-0.13	0.99	0.00	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	C1orf167	0.07	0.01	blup	475	0.03	1.4e-04	-13.54	-10.8	3.8e-27	0.43	0.36	0.04	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	NPPA-AS1	0.38	0.41	lasso	12	0.50	4.6e-73	-4.50	9.5	2.3e-21	-0.40	1.00	0.00	FALSE
41	YFS	Blood	FBXO6	0.15	0.07	enet	14	0.10	1.7e-30	-2.95	5.5	3.6e-08	-0.16	1.00	0.00	TRUE
42	YFS	Blood	MTHFR	0.50	0.49	enet	40	0.62	5.5e-264	-9.76	-13.1	2.4e-39	0.52	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLCN6	0.06	0.06	blup	104	0.06	5.0e-12	-15.55	-20.7	1.2e-95	0.75	0.18	0.82	TRUE
44	The Cancer Genome Atlas	Colon Adenocarcinoma	CLCN6	0.14	0.05	blup	104	0.09	1.2e-05	-19.16	-14.5	2.4e-47	0.81	0.01	0.98	FALSE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	MTHFR	0.07	0.01	blup	92	0.04	2.9e-03	-2.21	-14.1	5.8e-45	0.76	0.04	0.47	TRUE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	NPPA	0.06	0.01	lasso	5	0.01	1.3e-01	-6.46	10.8	2.3e-27	-0.34	0.04	0.24	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CLCN6	0.04	0.06	lasso	2	0.05	1.1e-06	-15.55	-17.3	2.5e-67	0.69	0.11	0.88	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AGTRAP	0.04	0.02	blup	69	0.02	8.0e-04	-9.76	-6.5	5.6e-11	0.32	0.02	0.29	TRUE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CLCN6	0.05	0.05	lasso	6	0.05	9.2e-07	-10.58	-15.2	4.0e-52	0.51	0.47	0.50	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NPPA	0.10	0.07	lasso	7	0.07	6.5e-08	-6.46	7.4	1.1e-13	-0.22	0.98	0.01	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CLCN6	0.07	0.00	blup	104	0.03	7.9e-03	4.32	-13.9	9.0e-44	0.60	0.06	0.29	FALSE
52	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NPPA	0.08	0.02	blup	79	0.03	1.0e-02	-13.67	5.7	1.1e-08	-0.16	0.10	0.04	FALSE
53	The Cancer Genome Atlas	Lung Adenocarcinoma	CLCN6	0.06	0.04	blup	104	0.04	5.2e-06	-19.78	-20.6	3.1e-94	0.91	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Lung Adenocarcinoma	MTHFR	0.05	0.02	blup	92	0.02	2.5e-03	-9.76	-11.1	1.1e-28	0.44	0.16	0.06	FALSE
55	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AGTRAP	0.07	0.05	blup	69	0.05	3.7e-06	0.61	5.2	2.0e-07	-0.08	0.48	0.03	FALSE
56	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	NPPA	0.07	0.00	blup	79	0.04	9.7e-04	-6.46	7.5	4.5e-14	-0.35	0.10	0.07	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLCN6	0.10	0.07	blup	104	0.07	3.9e-08	-12.80	-18.7	9.7e-78	0.59	0.21	0.79	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	MTHFR	0.04	0.01	blup	92	0.02	1.3e-03	1.18	-5.2	1.9e-07	-0.03	0.12	0.03	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	NPPA	0.11	0.07	enet	12	0.11	1.0e-11	-4.50	6.2	7.0e-10	-0.46	0.99	0.01	TRUE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	CLCN6	0.07	0.04	blup	104	0.05	2.4e-04	-19.16	-18.8	5.9e-79	0.94	0.01	0.98	FALSE
61	The Cancer Genome Atlas	Stomach Adenocarcinoma	NPPA	0.06	0.03	enet	4	0.04	7.6e-04	-12.80	10.7	1.5e-26	-0.45	0.11	0.14	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	CLCN6	0.08	0.02	blup	104	0.05	2.5e-05	-13.54	-15.9	1.0e-56	0.64	0.15	0.84	FALSE