Best TWAS P=4.63e-11 · Best GWAS P=3.14e-10 conditioned to 0.0213
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DNAJC11 | 0.03 | 0.03 | lasso | 5 | 0.04 | 3.1e-05 | 5.4 | 6.1 | 1.4e-09 | -0.78 | 0.03 | 0.95 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | TNFRSF25 | 0.09 | 0.03 | enet | 22 | 0.06 | 1.1e-07 | 3.0 | 5.3 | 1.2e-07 | -0.29 | 0.15 | 0.74 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | THAP3 | 0.10 | 0.03 | lasso | 2 | 0.02 | 6.8e-02 | 5.6 | -5.7 | 1.0e-08 | 0.48 | 0.07 | 0.09 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | GPR153 | 0.07 | -0.01 | enet | 3 | 0.00 | 4.3e-01 | 5.6 | -5.3 | 1.1e-07 | 0.50 | 0.04 | 0.09 | FALSE |
| 5 | GTEx | Heart Left Ventricle | THAP3 | 0.12 | 0.07 | lasso | 7 | 0.09 | 1.9e-05 | -5.3 | 5.7 | 1.1e-08 | -0.90 | 0.03 | 0.97 | FALSE |
| 6 | GTEx | Testis | THAP3 | 0.22 | 0.19 | lasso | 5 | 0.22 | 3.1e-10 | 5.6 | 6.6 | 4.6e-11 | -0.71 | 0.18 | 0.82 | TRUE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DNAJC11 | 0.02 | 0.00 | blup | 74 | 0.01 | 9.1e-03 | 5.6 | 6.2 | 4.1e-10 | -0.74 | 0.03 | 0.53 | FALSE |
| 8 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | THAP3 | 0.08 | 0.04 | enet | 7 | 0.04 | 3.7e-03 | -6.3 | 6.4 | 1.5e-10 | -0.87 | 0.01 | 0.91 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | THAP3 | 0.05 | 0.04 | blup | 51 | 0.05 | 4.4e-06 | -5.9 | 6.3 | 2.4e-10 | -0.96 | 0.01 | 0.99 | FALSE |