[Hub]/) : Traits : Systolic Blood Pressure :

chr2:84,662,093-87,126,250

Best TWAS P=1.77e-14 · Best GWAS P=1.36e-13 conditioned to 0.635

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex IMMT 0.17 0.20 enet 8 0.20 1.2e-23 -4.5 -5.1 3.0e-07 0.81 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex MRPL35 0.19 0.28 enet 17 0.28 5.0e-34 -4.5 -5.2 2.3e-07 0.81 1.00 0.00 FALSE
3 GTEx Adrenal Gland REEP1 0.21 0.05 lasso 5 0.06 2.6e-03 -7.1 7.0 2.3e-12 -0.70 0.03 0.92 FALSE
4 GTEx Artery Aorta TCF7L1 0.39 0.21 lasso 7 0.20 3.7e-11 -6.6 -6.1 9.3e-10 0.07 0.00 1.00 TRUE
5 GTEx Artery Tibial TCF7L1 0.15 0.04 enet 6 0.03 2.6e-03 5.4 -5.9 3.7e-09 0.08 0.01 0.99 FALSE
6 GTEx Brain Caudate basal ganglia REEP1 0.14 0.11 lasso 3 0.04 2.1e-02 3.8 5.3 1.2e-07 -0.79 0.09 0.49 FALSE
7 GTEx Brain Frontal Cortex BA9 REEP1 0.22 0.16 enet 10 0.10 1.0e-03 -4.5 5.8 8.6e-09 -0.84 0.05 0.83 FALSE
8 GTEx Brain Frontal Cortex BA9 MRPL35 0.16 0.07 lasso 2 0.05 2.3e-02 -4.5 -5.5 3.6e-08 0.83 0.05 0.66 FALSE
9 GTEx Brain Hippocampus RP11-301O19.1 0.14 0.11 lasso 3 0.08 7.8e-03 -6.0 5.8 9.0e-09 -0.81 0.12 0.52 FALSE
10 GTEx Brain Nucleus accumbens basal ganglia IMMT 0.18 0.01 enet 5 0.05 2.2e-02 -4.5 -5.8 7.8e-09 0.68 0.13 0.13 FALSE
11 GTEx Brain Putamen basal ganglia REEP1 0.20 0.18 lasso 7 0.18 5.0e-05 3.5 5.3 1.0e-07 -0.79 0.10 0.73 FALSE
12 GTEx Brain Putamen basal ganglia IMMT 0.21 0.07 lasso 5 0.03 7.3e-02 4.5 -5.3 1.2e-07 0.62 0.09 0.10 FALSE
13 GTEx Breast Mammary Tissue MRPL35 0.10 0.05 lasso 8 0.08 8.9e-05 -4.5 7.0 2.1e-12 -0.86 0.07 0.87 FALSE
14 GTEx Breast Mammary Tissue (Female) MRPL35 0.14 0.02 enet 17 -0.01 8.0e-01 -4.5 5.4 5.7e-08 -0.59 0.05 0.31 FALSE
15 GTEx Colon Sigmoid RP11-301O19.1 0.22 0.17 enet 29 0.16 3.4e-06 4.1 5.6 2.7e-08 -0.77 0.62 0.36 FALSE
16 GTEx Esophagus Muscularis REEP1 0.06 0.02 lasso 1 0.03 5.1e-03 -5.2 -5.2 1.8e-07 0.83 0.18 0.48 FALSE
17 GTEx Heart Atrial Appendage MRPL35 0.21 0.16 lasso 2 0.13 1.4e-06 -7.2 6.8 1.4e-11 -0.92 0.01 0.98 FALSE
18 GTEx Heart Left Ventricle MRPL35 0.10 0.08 enet 12 0.10 9.4e-06 -7.2 5.7 1.4e-08 -0.66 0.02 0.96 FALSE
19 GTEx Lung REEP1 0.15 0.06 enet 34 0.14 1.2e-10 -5.2 -6.0 1.9e-09 0.69 0.01 0.99 FALSE
20 GTEx Lung IMMT 0.18 0.20 enet 23 0.20 4.0e-15 4.3 -5.6 1.8e-08 0.83 0.88 0.12 FALSE
21 GTEx Ovary MRPL35 0.17 0.04 enet 15 0.07 1.0e-02 2.0 5.8 5.2e-09 -0.46 0.12 0.19 FALSE
22 GTEx Pancreas IMMT 0.18 0.13 lasso 2 0.15 6.5e-07 -4.5 -5.8 5.4e-09 0.85 0.05 0.95 FALSE
23 GTEx Stomach MRPL35 0.40 0.10 enet 29 0.14 5.0e-07 -4.4 5.5 3.2e-08 -0.67 0.04 0.95 FALSE
24 GTEx Thyroid IMMT 0.11 0.09 lasso 13 0.11 6.9e-09 -4.7 -5.9 3.0e-09 0.87 0.07 0.93 FALSE
25 GTEx Whole Blood IMMT 0.06 0.05 enet 26 0.06 1.9e-06 4.3 -5.2 2.0e-07 0.76 0.62 0.38 FALSE
26 NTR Blood IMMT 0.04 0.05 lasso 4 0.05 2.3e-15 5.5 -5.2 2.0e-07 0.76 0.99 0.01 FALSE
27 ROSMAP Brain Pre-frontal Cortex REEP1 0.11 0.12 lasso 11 0.14 3.7e-17 -7.2 6.8 1.0e-11 -0.93 0.01 0.99 FALSE
28 ROSMAP Brain Pre-frontal Cortex AC105053.4 0.10 0.08 lasso 6 0.11 7.0e-14 -5.4 7.0 2.6e-12 -0.65 0.60 0.40 FALSE
29 The Cancer Genome Atlas Breast Invasive Carcinoma MRPL35 0.04 0.02 enet 7 0.02 1.6e-04 -7.2 7.7 1.8e-14 -0.88 0.01 0.98 TRUE
30 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IMMT 0.03 0.03 blup 81 0.03 2.8e-04 -4.5 -5.2 1.9e-07 0.81 0.09 0.82 FALSE
31 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma POLR1A 0.07 0.00 lasso 4 0.01 2.1e-02 3.2 -5.4 5.4e-08 0.55 0.01 0.44 FALSE
32 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MRPL35 0.11 0.05 lasso 5 0.05 1.5e-06 -7.2 7.6 3.9e-14 -0.97 0.01 0.99 FALSE
33 The Cancer Genome Atlas Brain Lower Grade Glioma ATOH8 0.06 0.00 blup 84 0.04 6.4e-05 4.1 -5.6 2.5e-08 0.00 0.04 0.26 TRUE
34 The Cancer Genome Atlas Liver Hepatocellular Carcinoma MRPL35 0.08 0.04 lasso 3 0.05 3.1e-03 -7.1 6.8 9.2e-12 -0.93 0.03 0.83 FALSE
35 The Cancer Genome Atlas Prostate Adenocarcinoma IMMT 0.10 0.06 lasso 4 0.07 2.2e-07 -4.5 -5.7 1.1e-08 0.84 0.08 0.92 FALSE
36 The Cancer Genome Atlas Stomach Adenocarcinoma IMMT 0.10 0.06 lasso 4 0.08 1.5e-06 -5.7 -5.5 4.0e-08 0.77 0.06 0.93 FALSE
37 The Cancer Genome Atlas Thyroid Carcinoma IMMT 0.11 0.12 enet 23 0.12 1.7e-11 -4.5 -6.3 3.8e-10 0.89 0.10 0.90 FALSE