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chr2:84,662,093-87,126,250

Best TWAS P=1.77e-14 · Best GWAS P=1.36e-13 conditioned to 0.635

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	IMMT	0.17	0.20	enet	8	0.20	1.2e-23	-4.5	-5.1	3.0e-07	0.81	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MRPL35	0.19	0.28	enet	17	0.28	5.0e-34	-4.5	-5.2	2.3e-07	0.81	1.00	0.00	FALSE
3	GTEx	Adrenal Gland	REEP1	0.21	0.05	lasso	5	0.06	2.6e-03	-7.1	7.0	2.3e-12	-0.70	0.03	0.92	FALSE
4	GTEx	Artery Aorta	TCF7L1	0.39	0.21	lasso	7	0.20	3.7e-11	-6.6	-6.1	9.3e-10	0.07	0.00	1.00	TRUE
5	GTEx	Artery Tibial	TCF7L1	0.15	0.04	enet	6	0.03	2.6e-03	5.4	-5.9	3.7e-09	0.08	0.01	0.99	FALSE
6	GTEx	Brain Caudate basal ganglia	REEP1	0.14	0.11	lasso	3	0.04	2.1e-02	3.8	5.3	1.2e-07	-0.79	0.09	0.49	FALSE
7	GTEx	Brain Frontal Cortex BA9	REEP1	0.22	0.16	enet	10	0.10	1.0e-03	-4.5	5.8	8.6e-09	-0.84	0.05	0.83	FALSE
8	GTEx	Brain Frontal Cortex BA9	MRPL35	0.16	0.07	lasso	2	0.05	2.3e-02	-4.5	-5.5	3.6e-08	0.83	0.05	0.66	FALSE
9	GTEx	Brain Hippocampus	RP11-301O19.1	0.14	0.11	lasso	3	0.08	7.8e-03	-6.0	5.8	9.0e-09	-0.81	0.12	0.52	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	IMMT	0.18	0.01	enet	5	0.05	2.2e-02	-4.5	-5.8	7.8e-09	0.68	0.13	0.13	FALSE
11	GTEx	Brain Putamen basal ganglia	REEP1	0.20	0.18	lasso	7	0.18	5.0e-05	3.5	5.3	1.0e-07	-0.79	0.10	0.73	FALSE
12	GTEx	Brain Putamen basal ganglia	IMMT	0.21	0.07	lasso	5	0.03	7.3e-02	4.5	-5.3	1.2e-07	0.62	0.09	0.10	FALSE
13	GTEx	Breast Mammary Tissue	MRPL35	0.10	0.05	lasso	8	0.08	8.9e-05	-4.5	7.0	2.1e-12	-0.86	0.07	0.87	FALSE
14	GTEx	Breast Mammary Tissue (Female)	MRPL35	0.14	0.02	enet	17	-0.01	8.0e-01	-4.5	5.4	5.7e-08	-0.59	0.05	0.31	FALSE
15	GTEx	Colon Sigmoid	RP11-301O19.1	0.22	0.17	enet	29	0.16	3.4e-06	4.1	5.6	2.7e-08	-0.77	0.62	0.36	FALSE
16	GTEx	Esophagus Muscularis	REEP1	0.06	0.02	lasso	1	0.03	5.1e-03	-5.2	-5.2	1.8e-07	0.83	0.18	0.48	FALSE
17	GTEx	Heart Atrial Appendage	MRPL35	0.21	0.16	lasso	2	0.13	1.4e-06	-7.2	6.8	1.4e-11	-0.92	0.01	0.98	FALSE
18	GTEx	Heart Left Ventricle	MRPL35	0.10	0.08	enet	12	0.10	9.4e-06	-7.2	5.7	1.4e-08	-0.66	0.02	0.96	FALSE
19	GTEx	Lung	REEP1	0.15	0.06	enet	34	0.14	1.2e-10	-5.2	-6.0	1.9e-09	0.69	0.01	0.99	FALSE
20	GTEx	Lung	IMMT	0.18	0.20	enet	23	0.20	4.0e-15	4.3	-5.6	1.8e-08	0.83	0.88	0.12	FALSE
21	GTEx	Ovary	MRPL35	0.17	0.04	enet	15	0.07	1.0e-02	2.0	5.8	5.2e-09	-0.46	0.12	0.19	FALSE
22	GTEx	Pancreas	IMMT	0.18	0.13	lasso	2	0.15	6.5e-07	-4.5	-5.8	5.4e-09	0.85	0.05	0.95	FALSE
23	GTEx	Stomach	MRPL35	0.40	0.10	enet	29	0.14	5.0e-07	-4.4	5.5	3.2e-08	-0.67	0.04	0.95	FALSE
24	GTEx	Thyroid	IMMT	0.11	0.09	lasso	13	0.11	6.9e-09	-4.7	-5.9	3.0e-09	0.87	0.07	0.93	FALSE
25	GTEx	Whole Blood	IMMT	0.06	0.05	enet	26	0.06	1.9e-06	4.3	-5.2	2.0e-07	0.76	0.62	0.38	FALSE
26	NTR	Blood	IMMT	0.04	0.05	lasso	4	0.05	2.3e-15	5.5	-5.2	2.0e-07	0.76	0.99	0.01	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	REEP1	0.11	0.12	lasso	11	0.14	3.7e-17	-7.2	6.8	1.0e-11	-0.93	0.01	0.99	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	AC105053.4	0.10	0.08	lasso	6	0.11	7.0e-14	-5.4	7.0	2.6e-12	-0.65	0.60	0.40	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	MRPL35	0.04	0.02	enet	7	0.02	1.6e-04	-7.2	7.7	1.8e-14	-0.88	0.01	0.98	TRUE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IMMT	0.03	0.03	blup	81	0.03	2.8e-04	-4.5	-5.2	1.9e-07	0.81	0.09	0.82	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POLR1A	0.07	0.00	lasso	4	0.01	2.1e-02	3.2	-5.4	5.4e-08	0.55	0.01	0.44	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MRPL35	0.11	0.05	lasso	5	0.05	1.5e-06	-7.2	7.6	3.9e-14	-0.97	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATOH8	0.06	0.00	blup	84	0.04	6.4e-05	4.1	-5.6	2.5e-08	0.00	0.04	0.26	TRUE
34	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MRPL35	0.08	0.04	lasso	3	0.05	3.1e-03	-7.1	6.8	9.2e-12	-0.93	0.03	0.83	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	IMMT	0.10	0.06	lasso	4	0.07	2.2e-07	-4.5	-5.7	1.1e-08	0.84	0.08	0.92	FALSE
36	The Cancer Genome Atlas	Stomach Adenocarcinoma	IMMT	0.10	0.06	lasso	4	0.08	1.5e-06	-5.7	-5.5	4.0e-08	0.77	0.06	0.93	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	IMMT	0.11	0.12	enet	23	0.12	1.7e-11	-4.5	-6.3	3.8e-10	0.89	0.10	0.90	FALSE