Best TWAS P=2.12e-10 · Best GWAS P=1.03e-10 conditioned to 0.584
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | OLA1 | 0.22 | 0.24 | enet | 22 | 0.25 | 2.8e-30 | 5.8 | 6.0 | 2.7e-09 | 0.18 | 0.17 | 0.83 | TRUE |
| 2 | GTEx | Brain Cortex | WIPF1 | 0.23 | 0.16 | enet | 29 | 0.18 | 9.9e-06 | -3.3 | -6.1 | 8.0e-10 | -0.37 | 0.20 | 0.20 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | WIPF1 | 0.14 | 0.04 | lasso | 4 | 0.05 | 1.3e-04 | 5.1 | 5.3 | 9.7e-08 | 0.75 | 0.52 | 0.36 | FALSE |
| 4 | GTEx | Thyroid | WIPF1 | 0.11 | 0.10 | lasso | 1 | 0.09 | 1.6e-07 | 5.4 | 5.4 | 6.1e-08 | 0.80 | 0.55 | 0.44 | FALSE |
| 5 | NTR | Blood | SCRN3 | 0.01 | 0.00 | blup | 386 | 0.00 | 1.1e-02 | 3.6 | 5.5 | 3.8e-08 | 0.43 | 0.21 | 0.09 | FALSE |
| 6 | YFS | Blood | OLA1 | 0.01 | 0.00 | lasso | 2 | 0.00 | 1.5e-01 | 4.8 | 5.7 | 1.3e-08 | 0.30 | 0.05 | 0.58 | FALSE |
| 7 | YFS | Blood | WIPF1 | 0.19 | 0.16 | enet | 32 | 0.19 | 2.4e-61 | 5.5 | 6.3 | 2.1e-10 | 0.89 | 0.02 | 0.98 | TRUE |
| 8 | The Cancer Genome Atlas | Glioblastoma Multiforme | OLA1 | 0.12 | 0.13 | lasso | 2 | 0.09 | 1.4e-03 | 5.9 | 5.9 | 2.9e-09 | 0.09 | 0.02 | 0.91 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | OLA1 | 0.06 | 0.05 | lasso | 3 | 0.06 | 8.6e-08 | 5.8 | 5.4 | 8.5e-08 | 0.11 | 0.06 | 0.94 | FALSE |