Hub : Genes

HOXD-AS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.196	0.0600	5.8e-04	0.070	NA	0.025	NA	0.051	2.4e-06	NA	3.9e-03	NA	4.7e-05
2	GTEx	Heart Left Ventricle	0.285	0.0656	3.1e-05	0.143	NA	0.152	NA	0.140	5.0e-08	NA	1.7e-08	NA	6.5e-08
3	GTEx	Nerve Tibial	0.200	0.0511	4.4e-06	0.120	NA	0.078	NA	0.105	7.4e-09	NA	3.3e-06	NA	6.8e-08
4	GTEx	Testis	0.527	0.0650	8.2e-15	0.495	NA	0.437	NA	0.494	7.8e-25	NA	3.4e-21	NA	9.2e-25
5	ROSMAP	Brain Pre-frontal Cortex	0.112	0.0267	1.9e-07	0.060	0.07	0.081	0.077	0.090	3.7e-08	2.3e-09	1.5e-10	3.8e-10	1.4e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.3	2.5	1.1	1.6	1.0	-1.1	0.7
Bipolar Disorder or Schizophrenia	1.5	3.5	5.5	2.3	0.3	2.3	-2.2	1.3
Depressed Affect (Nagel 2018)	0.5	1.0	2.8	0.9	1.7	0.7	-0.9	-0.4
Depression (Nagel 2018)	0.6	0.9	2.1	-0.8	0.7	-1.1	0.5	-1.4
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.8	-1.1	1.9	-1.0	0.6	-1.2
Neuroticism (Nagel 2018)	0.4	0.9	2.2	1.0	0.6	0.9	-1.5	-0.3
Schizophrenia (2018)	1.5	3.0	4.7	2.1	-0.9	2.2	-2.0	1.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.2	-0.3	0.6	0.2	-0.3
Worry (Nagel 2018)	0.3	0.6	0.9	0.7	0.8	0.5	-0.9	-1.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	0.2	-0.2	0.6	-0.2	0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.4	-0.6	-0.6	0.4	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.5	1.2	0.6	-0.8	0.6	-0.3	1.1
Crohns Disease (2017)	1.5	3.2	9.2	1.8	0.5	1.5	-1.2	3.0
Irritable Bowel Disease (IBD)	1.9	4.6	15.3	1.6	1.5	1.4	-0.8	3.9
Ulcerative Colitis (UC)	1.1	2.0	7.0	0.8	1.4	0.8	-0.1	2.6
Major Depression (MDD)	0.3	0.4	1.2	0.1	1.1	0.6	-0.6	0.4
Reaction Time	0.7	1.3	3.0	-0.2	-1.7	-0.5	0.6	1.7
Verbal and Numeric Reasoning (VNR)	1.4	3.5	5.3	-1.7	1.9	-1.6	1.6	-2.3
Breast Cancer	0.1	0.2	0.5	-0.5	-0.3	-0.4	0.2	-0.7
Ovarian Cancer	4.5	6.0	10.3	2.3	0.4	2.0	-3.2	-3.2
Prostate Cancer	0.8	1.1	3.2	0.4	0.8	1.0	-0.7	1.8
Age at First Birth	1.7	2.5	3.8	1.7	-0.9	1.9	-1.6	1.5
Bipolar Disorder (2011)	1.7	1.6	2.9	1.4	0.8	1.4	-1.7	0.8
Body Mass Index (BMI) (2010)	1.4	1.9	3.8	2.0	0.2	1.7	-1.7	-0.3
Coronary Artery Disease (CAD)	0.3	0.3	0.9	0.7	-0.3	0.2	-0.9	-0.4
Crohns Disease (2012)	0.9	1.4	3.5	1.0	1.3	0.9	-0.5	1.9
Mean Putamen Volume	2.0	2.3	5.3	1.3	0.1	1.4	-1.5	2.3
Fasting Glucose	1.0	1.2	3.3	-0.4	1.5	-0.4	0.5	-1.8
HbA1C	0.5	0.5	0.9	0.9	1.0	0.5	-0.8	-0.0
HDL Cholesterol	1.3	2.2	4.4	-1.4	0.2	-1.5	1.4	-2.1
LDL Cholesterol	0.5	0.8	1.6	-0.8	-0.5	-0.5	1.2	-1.3
Lupus	3.9	5.9	8.6	2.9	-0.8	2.8	-2.6	2.4
Neuroticism (2016)	0.8	1.1	3.0	-0.2	1.7	-0.7	0.5	-1.4
Primary Biliary Cirrhosis	4.2	6.0	10.7	3.1	-0.5	2.8	-3.3	1.2
Rheumatoid Arthritis	0.5	0.6	1.1	-0.8	0.5	-1.0	1.1	0.1
Schizophrenia (2014)	1.1	2.5	3.8	1.9	-0.5	1.8	-1.7	1.5
Triglycerides	0.2	0.4	1.8	0.1	0.2	-0.1	0.1	-1.4
Type 2 Diabetes (T2D) (2012)	3.2	3.6	6.1	2.5	1.4	2.0	-2.5	-0.1
Ulcerative Colitis	1.2	1.7	4.4	1.1	0.5	1.4	-0.9	2.1
Blood Eosinophil Count	0.0	0.3	0.5	0.7	0.7	0.5	-0.2	0.4
Blood Platelet Count	0.2	2.3	5.8	1.1	-1.1	1.7	-0.5	2.4
Blood Red Count	0.9	9.0	17.9	2.8	-0.7	3.0	-4.2	-3.0
Blood White Count	0.0	0.3	0.9	-0.4	0.0	-0.2	0.6	1.0
Heel T-Score	1.8	14.0	24.1	-4.6	-0.7	-4.9	4.8	-1.2
BMI	0.1	0.7	3.4	-0.2	0.3	0.0	0.3	-1.8
Height	0.1	2.4	3.7	-1.9	0.9	-1.9	1.8	0.8
Waist Hip Ratio (WHR)	0.7	3.0	9.1	1.6	-1.0	1.6	-0.2	3.0
Systolic Blood Pressure	4.8	24.1	42.2	-5.0	1.6	-5.2	4.8	-6.5
Smoking Status	0.4	1.0	2.1	-1.3	-0.1	-1.1	1.4	-0.6
Allergy or Eczema	0.1	0.2	0.4	0.6	0.3	0.5	-0.3	-0.3
Cardiovascular Disease	1.3	4.3	11.8	-1.6	1.5	-1.7	1.5	-3.4
Hypothyroidism (self reported)	0.3	0.7	1.2	-1.1	0.8	-0.6	0.9	0.7
Respiratory disease	0.1	0.3	0.6	-0.5	-0.0	-0.7	0.8	-0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	0.5	-0.4	0.5	-0.2	0.4
Lung FEV1/FVC ratio	5.1	26.0	42.0	6.0	0.5	5.6	-6.5	4.5
Lung FVC	0.4	1.8	4.2	1.0	-1.5	0.7	-1.2	-2.0
Neuroticism	0.3	0.8	1.4	1.0	0.7	1.1	-1.2	-0.3
Chronotype (morning person)	0.6	1.4	3.7	0.7	-1.0	1.0	-0.8	1.9
Hair Pigment	0.1	3.0	4.1	-2.0	-1.7	-1.7	1.8	-1.4
Tanning	0.3	3.7	7.8	-1.0	2.8	-1.1	1.5	2.5
Hand grip strength (left)	0.9	2.4	3.1	-1.7	-0.6	-1.6	1.7	-1.8
Number of treatments/medications taken	0.1	0.3	0.9	0.1	0.3	0.3	-0.4	-1.0
Average weekly spirits intake	1.2	1.5	4.0	-0.9	2.0	-1.1	0.7	-0.9
Sensitivity / hurt feelings	0.1	0.2	0.5	0.4	-0.7	0.2	-0.3	-0.5
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.4	-1.1	0.7	-1.4	0.9	-1.5
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.6	0.0	0.8	-0.5	-0.2
Relative age of first facial hair	1.3	2.7	12.9	0.4	-3.6	-0.0	-0.4	-0.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.1	-0.2	0.2	-0.2	-0.5
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.4	-0.5	1.1	-0.5	0.6	1.2
Ever had hysterectomy (womb removed)	0.8	0.9	2.1	-1.5	0.4	-1.1	0.8	-0.4
Systolic blood pressure, automated reading	3.0	8.7	23.8	-2.6	0.5	-2.5	2.4	-4.9
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.1	-0.0	-0.3	0.0	0.2
Angina	0.2	0.2	1.0	0.1	1.0	0.1	0.2	-0.2
Medication for hormone replacement therapy	1.5	1.7	3.5	0.9	-1.4	1.1	-0.9	1.9
Vitamin and mineral supplements	0.9	1.2	1.5	1.1	1.2	1.1	-0.9	1.0
Supplements: Zinc	0.4	0.4	1.0	-0.7	-1.0	-0.5	0.2	-0.5
Medication: Co-codamol	0.3	0.3	0.7	-0.3	0.4	-0.8	0.7	-0.2
Medication: Metformin	1.1	1.5	3.0	1.5	0.1	1.7	-1.5	0.5
Diabetes (father)	0.1	0.1	0.2	-0.4	0.4	-0.2	-0.3	0.5
Diabetes (mother)	1.2	1.5	2.8	0.9	1.7	0.8	-1.1	1.5
Severe depression (siblings)	0.2	0.2	0.5	0.4	-0.3	0.7	-0.3	0.6
Pack years adult smoking proportion	0.8	1.2	5.3	0.4	-0.2	0.4	-0.6	2.3
Impedance of leg (right)	2.0	9.5	39.8	1.4	0.6	1.6	-1.6	6.3
Leg fat-free mass (left)	0.7	3.5	8.8	-1.7	0.8	-1.4	1.8	-3.0
Trunk fat percentage	0.6	2.6	9.8	0.2	1.5	0.9	-0.2	3.1
Hand grip strength (right)	1.6	4.3	5.8	-2.2	-1.2	-2.0	2.3	-2.4
Townsend deprivation index at recruitment	2.4	3.4	6.2	1.8	0.4	2.4	-1.4	2.5
Current tobacco smoking	0.9	1.5	2.7	-1.6	0.2	-1.4	1.6	-0.7
Average weekly fortified wine intake	0.1	0.1	0.3	0.1	-0.2	0.1	-0.3	-0.6
Maternal smoking around birth	0.5	0.7	1.5	0.6	1.0	1.2	-0.8	0.3
Fed-up feelings	0.6	1.1	3.2	0.9	1.8	0.7	-0.9	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	-0.0	1.0	-0.5	-0.0	-1.5
Relative age voice broke	0.2	0.3	0.8	-0.2	-0.9	-0.7	0.1	-0.4
Taking other prescription medications	0.9	1.4	2.1	1.4	1.3	1.3	-1.1	0.5
Age when periods started (menarche)	0.3	0.7	2.3	-0.6	0.4	-1.5	0.4	-0.6
Bilateral oophorectomy (both ovaries removed)	3.7	4.3	7.9	-2.8	1.7	-2.6	1.9	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.3	5.9	-2.2	1.1	-2.1	2.4	-2.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.9	-0.5	-0.3	-0.9	0.7	-0.8
Qualifications: CSEs or equivalent	0.7	0.9	1.8	0.6	1.3	0.7	0.1	1.3
Serious illness, injury or assault to yourself	0.3	0.3	0.5	0.7	0.6	0.4	-0.6	0.4
High blood pressure	1.7	4.7	14.8	-1.8	1.0	-1.6	1.4	-3.9
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	0.6	0.8	0.5	-0.3	-0.3
Multivitamins +/- minerals	0.5	0.6	2.1	-0.6	-1.4	-0.5	0.5	0.0
Stomach or abdominal pain in last month	0.6	0.7	1.2	-0.8	0.8	-0.8	0.8	-1.1
Supplements: Glucosamine	0.6	0.8	1.5	-1.2	0.6	-0.9	1.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	-0.6	0.8	-0.9	0.6	0.3
Medication: Atenolol	1.0	1.2	4.4	0.0	1.2	0.3	0.0	-2.1
Medication: Levothyroxine sodium	0.2	0.3	0.7	-0.5	0.8	-0.3	0.3	0.4
Sitting height	0.1	0.8	2.4	-0.6	-0.2	-0.6	0.8	-1.6
Chronic bronchitis/emphysema (father)	0.6	0.8	1.4	-1.2	0.1	-1.1	0.9	0.6
High blood pressure (mother)	0.7	1.0	1.9	1.4	-0.3	1.2	-1.4	-0.0
Body mass index (BMI)	0.2	0.9	3.0	-0.3	1.1	0.2	0.1	-1.7
Impedance of leg (left)	2.5	12.3	46.1	2.1	0.9	2.2	-2.2	6.8
Leg predicted mass (left)	0.6	3.4	8.3	-1.7	0.8	-1.4	1.8	-2.9
Trunk fat mass	0.3	1.2	3.5	-0.3	1.9	0.3	0.2	1.6
Waist circumference	0.2	0.7	3.3	0.0	1.8	0.4	0.2	0.2
Number of incorrect matches in round	1.4	2.4	8.5	1.2	1.1	0.7	-0.6	2.9
Past tobacco smoking	0.1	0.2	0.4	0.2	0.5	0.0	-0.3	-0.6
Alcohol usually taken with meals	0.8	1.2	3.2	-0.5	-1.8	-0.6	0.6	-1.5
Nervous feelings	0.2	0.4	0.6	0.6	-0.4	0.7	-0.8	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	-0.0	0.1	-0.4	-0.3	-0.2
Hearing difficulty/problems with background noise	0.4	0.7	1.3	0.9	0.2	1.1	-0.9	0.7
Hair/balding pattern: Pattern 2	1.4	1.8	3.7	1.1	1.2	1.1	-1.2	1.9
Had menopause	0.3	0.4	0.7	-0.8	-0.2	-0.8	0.8	0.2
Had other major operations	0.8	0.9	2.0	-0.7	-1.0	-0.9	0.5	-1.4
Forced vital capacity (FVC)	0.1	0.5	1.0	-0.4	-0.6	-0.8	0.6	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	4.1	-2.0	1.0	-2.0	2.0	-1.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.9	0.1	-0.9	-0.0	-0.2	0.3
Qualifications: None of the above	3.9	8.2	12.5	3.4	-1.1	3.4	-3.5	2.2
Financial difficulties in last 2 years	0.3	0.4	0.9	-0.6	-0.9	-0.7	0.6	-0.3
Mouth/teeth dental problems	0.8	1.2	1.8	-1.2	-1.4	-1.0	1.3	-0.1
Heart attack	0.2	0.2	0.4	-0.6	-0.3	-0.7	0.4	0.0
Allergy	0.4	1.0	1.7	0.5	-1.3	0.8	-1.0	1.0
Pain all over the body in last month	0.5	0.5	0.9	-0.4	-0.5	-0.7	1.0	0.9
Diabetes (self-reported)	0.3	0.4	0.8	0.8	0.9	0.5	-0.3	0.3
Hayfever/allergic rhinitis (self-reported)	1.8	2.3	3.9	-2.0	0.2	-1.5	1.8	-1.5
Medication: Ramipril	0.7	0.9	4.0	0.4	-0.5	0.2	-0.5	-2.0
Medication: Simvastatin	1.7	2.4	3.8	1.7	1.5	1.9	-1.7	0.7
Fluid intelligence score	0.5	1.0	1.1	-1.0	0.8	-1.1	1.0	-1.0
Illnesses of siblings	1.1	1.6	2.4	1.5	-0.6	1.2	-1.3	1.4
Neuroticism score	0.7	1.4	2.6	1.5	0.5	1.4	-1.6	0.1
Weight	0.3	1.4	3.1	-0.9	1.8	-0.5	0.8	-1.4
Impedance of arm (right)	2.1	9.8	48.0	0.8	-0.4	0.5	-0.1	6.9
Arm fat percentage (right)	0.1	0.4	0.9	-0.1	0.9	0.4	0.1	0.9
Trunk fat-free mass	1.3	7.3	22.3	-2.1	1.6	-1.9	2.0	-4.7
Hip circumference	0.7	2.9	7.0	-1.6	2.6	-1.2	1.3	-1.4
Time employed in main current job	0.7	0.8	2.0	0.5	1.4	0.3	-0.3	1.4
Alcohol intake versus 10 years previously	0.4	0.7	1.4	0.9	0.5	0.8	-1.2	0.1
Father’s age at death	0.3	0.4	1.5	0.5	-1.2	0.1	0.2	0.2
Worrier / anxious feelings	0.5	1.0	1.4	1.2	-0.7	0.7	-1.1	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.5	0.4	1.2	0.5	-0.3	0.1
Falls in the last year	0.7	0.9	1.8	1.0	1.3	1.0	-0.8	-0.0
Hair/balding pattern: Pattern 3	4.1	6.1	13.4	-2.5	0.2	-2.6	2.0	-3.7
Number of live births	1.9	2.7	4.1	2.0	-0.6	2.0	-1.7	1.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.5	1.2	-0.4	0.8	-1.2	-0.2
Pulse rate	1.7	2.9	11.5	1.0	0.2	1.1	-0.8	3.4
Happiness	0.3	0.3	0.6	-0.2	-0.0	-0.5	0.8	-0.8
Noisy workplace	1.4	1.7	3.1	1.1	-0.8	1.2	-1.4	1.8
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.1	-1.0	-1.3	-1.1	0.8	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	2.9	1.7	0.9	1.7	-1.7	0.8
Mouth/teeth dental problems: Dentures	2.3	3.9	6.9	2.6	1.0	1.9	-2.5	1.2
Asthma	0.7	1.3	2.9	-1.1	0.5	-1.5	1.7	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	5.2	1.0	-2.3	1.0	-1.1	-0.6
Medication: Cholesterol lowering	0.7	1.1	1.8	1.1	1.4	1.1	-1.0	0.3
Depression (self-reported)	0.5	0.6	1.2	1.0	0.2	1.1	-0.9	-0.3
Medication: Lansoprazole	0.5	0.5	1.1	0.8	-0.0	1.1	-0.9	0.3
Prospective memory result	1.0	1.3	2.2	-1.2	0.1	-1.3	1.5	-1.1
Lung cancer (father)	0.7	0.8	1.9	0.4	-0.7	0.7	-0.8	1.4
Illnesses of mother	0.3	0.4	0.7	-0.3	0.8	-0.3	0.7	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.9	1.2	-0.8	1.0	-1.4	0.1
Pulse wave Arterial Stiffness index	0.7	0.8	1.7	-0.9	1.3	-0.5	0.7	-0.8
Impedance of arm (left)	2.1	9.9	49.0	0.4	-0.6	0.2	0.2	7.0
Arm fat mass (right)	0.1	0.4	1.3	-0.6	1.1	0.0	0.5	-0.5
Trunk predicted mass	1.3	7.2	22.7	-2.0	1.6	-1.8	1.9	-4.8
Standing height	0.2	2.1	2.9	-1.5	1.4	-1.6	1.7	0.8
Length of working week for main job	0.3	0.3	1.0	0.6	-0.1	0.3	-1.0	-0.2
Exposure to tobacco smoke at home	0.6	0.7	1.8	0.6	0.5	0.4	-0.9	1.4
Breastfed as a baby	0.2	0.2	0.5	-0.4	-0.7	-0.6	0.5	-0.1
Tense / ‘highly strung’	0.8	1.3	3.3	1.0	0.1	0.8	-1.3	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.4	0.6	1.0	1.0	-1.2	-0.9
Hair/balding pattern: Pattern 4	5.2	12.5	17.1	-4.1	-3.0	-3.9	3.8	-2.6
Birth weight of first child	0.4	0.7	1.2	-1.0	0.5	-0.8	0.8	-1.1
Peak expiratory flow (PEF)	0.5	1.1	2.1	1.3	0.4	1.2	-1.5	-0.4
Pulse wave reflection index	1.3	1.6	5.4	-0.7	1.3	-0.4	0.3	-2.3
Ever highly irritable/argumentative for 2 days	1.9	2.2	3.2	1.5	-1.0	1.8	-1.7	1.2
Loud music exposure frequency	2.4	2.6	4.0	2.0	-0.6	1.7	-2.0	1.3
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	3.6	-1.9	-1.0	-1.8	1.9	-0.7
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	3.0	-0.8	0.7	-0.6	0.4	-1.7
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.2	-0.9	-0.0	0.1	-0.6
Medication: Paracetamol	0.2	0.3	0.6	-0.5	0.8	-0.3	0.6	0.5
Headache pain in last month	0.8	1.4	2.7	1.6	-1.0	1.1	-1.3	0.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	5.7	0.6	-1.7	0.3	-0.3	2.4
Glaucoma (self-reported)	0.2	0.2	0.4	-0.4	-0.3	-0.4	0.4	0.7
Gout (self-reported)	1.2	1.6	3.9	-0.7	-1.4	-0.7	1.1	-2.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.6	0.3	-0.1	0.5	0.7
Medication: Amlodipine	1.6	2.2	3.6	-1.5	1.3	-1.4	1.3	-1.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	-0.7	-0.6	-0.7	0.8	0.2
Birth weight	0.7	1.5	1.9	-1.2	0.6	-1.4	1.3	-1.3
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.0	-0.9	1.0	-1.0	0.7	-0.0
High blood pressure (siblings)	2.3	3.3	9.2	-1.7	0.1	-1.5	1.5	-3.0
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	-0.4	-0.9	-0.7	0.3	-0.7
Body fat percentage	0.6	2.2	6.7	0.6	1.6	1.1	-0.7	2.6
Leg fat percentage (right)	0.6	2.1	5.5	0.7	2.3	1.2	-1.0	1.5
Arm fat-free mass (right)	1.0	5.3	16.0	-1.8	1.8	-1.5	1.5	-4.0
Exposure to tobacco smoke outside home	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.1	-0.2
Comparative body size at age 10	1.8	4.9	7.6	2.4	-0.1	2.6	-2.8	2.1
Number of full brothers	0.7	0.8	1.5	0.8	-0.1	0.8	-1.2	1.1
Worry too long after embarrassment	0.8	1.3	2.1	1.2	-1.2	1.2	-1.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.3	1.3	-0.5	1.5	-1.3	-0.1
Wheeze or whistling in the chest in last year	0.3	0.5	1.2	-0.6	1.1	-0.6	0.7	0.4
Number of children fathered	2.1	2.4	4.6	-1.8	0.9	-1.7	2.1	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	3.3	1.7	-1.2	1.4	-1.8	-0.7
Age at first live birth	1.8	3.2	6.5	-1.4	-1.2	-1.7	1.8	-2.5
Pulse wave peak to peak time	0.8	0.9	1.4	0.9	-1.2	0.5	-0.8	1.2
Health satisfaction	1.3	1.7	4.5	-0.9	-0.8	-1.2	1.2	-2.1
Shortness of breath walking on level ground	0.7	0.9	1.8	-0.8	-0.6	-0.9	1.3	-0.9
Qualifications: College or University degree	0.8	2.4	5.1	-1.1	-2.3	-1.2	1.1	-1.7
Eye problems/disorders: None of the above	4.0	4.6	7.7	2.8	-0.1	2.7	-2.7	0.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.9	-0.2	1.7	-0.1	0.2	0.7
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.3	-0.4	-0.1	-0.3	-0.0
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	-0.2	0.2	-0.2	0.0	-0.1
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.0	0.6	0.2	-0.1	-0.1
Medication: Blood pressure	2.4	4.2	10.7	-1.8	1.6	-1.4	1.6	-3.3
Angina (self-reported)	0.1	0.2	0.8	0.1	0.9	0.1	0.2	-0.1
Migraine (self-reported)	0.9	1.1	4.9	0.3	-2.2	0.3	-0.4	-0.7
Medication: Ibuprofen	0.9	1.1	4.5	0.2	-2.1	0.1	-0.3	-0.9
Medication: Allopurinol	0.4	0.6	2.4	0.1	-1.6	-0.3	0.5	-0.3
Medication: Omeprazole	0.3	0.3	0.7	0.8	-0.5	0.4	-0.6	0.4
Medication: Seretide 50 evohaler	0.5	0.5	0.7	-0.7	-0.7	-0.9	0.8	0.5
Mean time to correctly identify matches	0.4	0.9	3.7	0.2	-0.6	-0.1	0.4	1.9
Heart disease (mother)	0.2	0.2	0.4	0.5	-0.3	0.3	-0.3	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.3	-1.0	1.1	-1.0	0.7	-1.5
Whole body fat mass	0.2	0.7	2.7	-0.0	1.6	0.5	-0.1	0.9
Leg fat mass (right)	0.2	0.9	3.7	0.2	1.9	0.7	-0.3	0.3
Arm predicted mass (right)	0.9	4.7	15.1	-1.7	1.4	-1.2	1.4	-3.9
Pulse rate, automated reading	0.3	1.0	2.3	-0.8	1.5	-0.6	0.8	0.9
Alcohol intake frequency.	0.9	2.1	3.0	1.7	0.8	1.6	-1.7	1.3
Comparative height size at age 10	0.2	1.0	2.5	0.4	1.6	1.1	-0.5	1.1
Number of full sisters	0.7	0.8	2.3	0.7	-0.1	0.8	-0.8	1.5
Suffer from ‘nerves’	0.6	0.9	1.5	1.2	-0.2	1.1	-1.1	0.8
Overall health rating	0.1	0.3	0.6	0.7	0.8	0.4	-0.2	-0.4
Chest pain or discomfort	1.7	2.5	3.8	1.7	-0.5	1.9	-1.7	1.6
Had major operations	0.5	0.6	1.7	-0.2	0.9	-0.4	0.2	1.3
Age at last live birth	0.4	0.5	1.7	-0.1	-1.3	-0.1	0.6	-0.8
Family relationship satisfaction	1.1	1.4	2.2	1.2	-1.5	1.2	-1.3	-0.5
Leg pain on walking	0.8	1.0	2.0	-1.1	0.2	-1.4	1.4	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.4	0.4	-0.1	0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	0.1	0.8	-0.3	0.3	-0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	0.5	-0.5	0.6	-0.7	0.1
Medication: Aspirin	0.3	0.4	0.5	-0.6	0.6	-0.5	0.7	-0.5
Supplements: Vitamin C	1.4	1.7	2.1	-1.5	-0.9	-1.4	1.2	-1.4
Knee pain experienced in last month	2.4	3.8	6.8	-1.7	2.6	-1.9	2.2	0.5
Hypertension (Self-reported)	1.6	4.5	14.5	-1.6	1.0	-1.5	1.4	-3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.0	0.6	0.3	-0.2	-0.1
Illnesses of father: Heart disease	0.2	0.2	0.5	0.5	-0.4	0.7	-0.4	-0.2
Illnesses of siblings: Diabetes	0.6	0.7	1.3	1.0	0.2	1.1	-1.1	0.4
Smoking status: Previous	0.1	0.1	0.1	0.1	-0.3	0.4	0.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.7	-1.1	0.8	-1.1	1.3	0.4
Whole body fat-free mass	1.1	6.2	18.2	-2.0	1.4	-1.8	1.9	-4.3
Leg fat-free mass (right)	0.5	2.7	7.5	-1.3	0.9	-1.2	1.5	-2.7
Arm fat percentage (left)	0.1	0.3	0.8	-0.3	0.8	0.2	0.4	0.9
Average weekly red wine intake	1.2	1.8	3.7	-1.5	-0.3	-1.7	1.9	-0.3
Handedness (chirality/laterality): Left-handed	1.2	1.4	4.1	0.1	-2.0	0.6	-0.5	1.5
Mood swings	0.5	0.9	1.5	1.1	0.8	1.1	-1.2	0.4
Loneliness, isolation	0.4	0.5	0.8	0.9	0.0	0.8	-0.9	0.7
Long-standing illness, disability or infirmity	1.3	2.0	8.9	-0.2	3.0	-0.1	0.5	0.9
Ever had bowel cancer screening	0.2	0.3	1.2	-0.3	-0.1	0.2	-0.2	-1.1
Diabetes diagnosed by doctor	0.4	0.7	2.5	0.8	1.6	0.6	-0.4	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.2	-0.1	-1.5	0.0	0.5	0.5
Friendships satisfaction	0.2	0.3	1.2	0.3	-0.2	0.1	-0.3	-1.1
Qualifications: nursing, teaching	0.5	0.9	1.1	-0.8	0.6	-1.0	1.0	-1.1
Commuting to job workplace: Walk	0.3	0.3	0.8	-0.3	-0.9	-0.0	-0.0	-0.7
Eye problems/disorders: Cataract	2.2	2.6	5.1	-2.0	-0.1	-2.0	2.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.5	-0.3	-0.3	-0.3	0.5	1.2
Medication for cholesterol	0.7	1.0	2.6	0.4	-1.4	0.4	-0.2	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.8	1.1	-1.3	1.1	-1.1	-0.1
Back pain experienced in last month	0.3	0.4	1.5	0.6	1.2	0.4	-0.4	0.1
Mineral and other dietary supplements	0.1	0.2	0.7	0.3	-0.1	0.2	-0.2	-0.9
Breast cancer (self-reported)	5.9	7.1	10.8	-2.9	1.3	-3.3	3.1	-2.1
Asthma (self-reported)	0.6	1.3	2.6	-1.1	0.6	-1.5	1.6	-0.3
Osteoporosis (self-reported)	1.9	2.3	3.6	1.9	0.9	1.8	-1.7	0.9
Osteoarthritis (self-reported)	1.6	2.1	4.2	-2.1	0.3	-1.5	1.9	0.5
Medication: Aspirin	0.1	0.1	0.2	-0.3	0.4	-0.3	0.4	-0.4
Medication: Gliclazide	0.2	0.2	0.8	0.0	0.2	-0.1	-0.1	-0.9
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.0	0.5	0.1	0.3	0.2
Smoking status: Current	0.5	0.9	1.5	-1.2	-0.2	-1.1	1.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	4.1	1.9	-1.2	1.3	-2.0	-1.1
Whole body water mass	1.1	6.4	18.4	-2.1	1.3	-1.9	2.0	-4.3
Leg predicted mass (right)	0.5	2.6	7.3	-1.3	0.9	-1.1	1.4	-2.7
Arm fat mass (left)	0.1	0.6	1.3	-0.8	1.1	-0.3	0.8	-0.4
Number of self-reported non-cancer illnesses	0.3	0.6	2.1	-0.3	0.9	0.0	0.2	-1.4
Average weekly champagne plus white wine intake	0.3	0.5	1.2	0.5	-0.4	0.7	-0.5	1.1
Miserableness	1.2	2.2	2.8	1.4	1.6	1.7	-1.5	1.0
Guilty feelings	0.8	1.2	1.6	1.3	-0.3	1.3	-1.2	1.1
Wears glasses or contact lenses	1.8	2.1	4.0	-2.0	0.6	-1.6	1.9	-0.5
Ever taken oral contraceptive pill	0.5	0.6	1.1	-0.8	0.3	-1.0	0.8	-0.6
Hearing aid user	0.9	1.0	1.8	-0.9	0.3	-1.3	0.9	-1.3
Mother’s age at death	0.1	0.1	0.5	-0.1	-0.4	-0.1	0.2	-0.7
Financial situation satisfaction	0.1	0.1	0.2	-0.1	-0.3	-0.3	0.4	0.4
Tinnitus: Yes, now most or all of the time	2.1	2.5	3.8	1.9	-1.3	1.8	-1.9	0.2
Commuting to job workplace: Public transport	0.9	1.1	4.3	0.3	-2.1	0.0	-0.6	0.8
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	-0.7	0.1	-0.7	0.6	0.6
Medication: Blood pressure	2.6	5.0	15.6	-1.6	0.8	-2.0	1.4	-4.0
Pain type(s) experienced in last month: Hip pain	1.4	1.8	6.2	0.6	2.5	0.7	-1.1	-0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.9	0.4	0.5	0.2	-0.3	1.4
High cholesterol (Self-reported)	1.1	1.9	3.1	1.6	1.0	1.8	-1.7	0.4
Medication: Bendroflumethiazide	5.0	7.6	12.7	-3.0	1.0	-2.8	2.7	-3.6
Medication: Paracetamol	0.5	0.7	1.4	-1.2	0.2	-1.0	1.0	-0.1
Medication: Lisinopril	0.5	0.6	2.3	-0.1	0.8	-0.4	0.0	-1.5
Medication: Atorvastatin	1.0	1.2	2.5	0.9	1.6	0.3	-0.7	-1.5
Illnesses of father: High blood pressure	0.2	0.3	0.6	-0.3	-0.8	-0.6	0.4	-0.4
Alcohol drinker status: Never	0.9	1.0	1.5	1.1	-1.0	1.0	-1.2	0.6
Ever smoked	0.4	0.7	1.7	0.1	-1.2	0.3	-0.2	1.3
Basal metabolic rate	0.8	4.4	11.9	-1.7	1.5	-1.4	1.7	-3.5
Leg fat percentage (left)	0.8	2.9	6.5	1.1	2.5	1.5	-1.4	1.6
Arm fat-free mass (left)	1.0	4.9	14.4	-1.7	1.9	-1.3	1.5	-3.8
Number of operations (self-reported)	0.7	1.0	1.7	-1.2	0.9	-1.3	1.0	-0.6
Average weekly beer plus cider intake	0.5	0.7	2.9	0.4	0.3	0.5	-0.3	1.7
Irritability	0.2	0.4	0.6	0.7	-0.3	0.8	-0.7	-0.6
Risk taking	0.5	0.7	1.2	0.8	-0.4	0.5	-1.0	1.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.2	-0.6	0.8	-0.4	-0.1	-1.5
Fractured/broken bones in last 5 years	0.5	0.7	1.5	-0.7	0.8	-1.2	0.6	0.6
Age started oral contraceptive pill	2.3	2.9	9.1	-1.2	0.6	-1.4	1.1	-3.0
Diastolic blood pressure, automated reading	2.7	8.3	11.3	-3.3	0.5	-2.8	3.4	-3.3
Ever depressed for a whole week	0.1	0.2	0.4	0.1	0.3	0.4	-0.6	-0.4
Unable to work because of sickness or disability	0.0	0.1	0.1	-0.2	0.3	-0.3	0.3	0.1
Commuting to job workplace: Cycle	0.2	0.2	0.7	0.2	-0.6	0.3	-0.1	0.8
Myopia	0.5	0.7	1.1	0.9	-1.0	0.9	-1.1	0.1
Vascular/heart problems diagnosed by doctor	1.1	3.1	9.8	1.5	-0.8	1.2	-1.2	3.1
Cholesterol lowering medication	0.4	0.6	1.6	0.7	1.3	0.6	-0.8	0.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.0	1.4	0.1	1.0	-1.3	1.0
Pain experienced in last month	0.4	0.6	1.5	0.6	-0.1	1.2	-1.0	-0.5
Supplements: Calcium	1.4	1.5	5.0	0.3	-2.2	-0.1	-0.1	-1.5
Basal cell carcinoma (self-reported)	0.9	1.1	3.2	0.1	1.8	0.0	-0.2	1.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.4	-0.3	-0.6	0.3	0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.2	0.1	-1.1	0.4	-0.2	-0.3
Heart disease (siblings)	1.1	1.4	2.3	-1.5	-0.3	-1.4	1.4	-0.8
Alcohol drinker status: Previous	0.7	0.8	1.3	0.8	-1.0	0.8	-1.2	0.8
Pack years of smoking	1.1	1.6	6.5	0.6	-0.3	0.5	-0.9	2.6
Impedance of whole body	2.5	12.8	58.7	1.4	0.0	1.4	-1.1	7.7
Leg fat mass (left)	0.3	1.0	4.0	0.3	2.0	0.8	-0.5	0.4
Arm predicted mass (left)	0.7	3.7	11.8	-1.3	1.8	-0.9	1.1	-3.4