Best TWAS P=4.03e-13 · Best GWAS P=1.54e-13 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CARF | 0.17 | 0.07 | enet | 23 | 0.09 | 6.2e-08 | 6.5 | -6.9 | 3.9e-12 | -0.88 | 0.04 | 0.96 | FALSE |
2 | GTEx | Artery Aorta | CARF | 0.07 | 0.00 | lasso | 5 | 0.00 | 2.5e-01 | 7.0 | -7.2 | 4.0e-13 | -0.96 | 0.02 | 0.81 | TRUE |
3 | GTEx | Artery Tibial | CARF | 0.05 | 0.02 | lasso | 3 | 0.02 | 7.5e-03 | 3.5 | -5.6 | 2.3e-08 | -0.77 | 0.06 | 0.81 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | CARF | 0.11 | 0.11 | enet | 13 | 0.13 | 8.0e-10 | 7.0 | -6.5 | 6.8e-11 | -0.88 | 0.03 | 0.97 | FALSE |
5 | GTEx | Colon Sigmoid | CARF | 0.12 | 0.06 | enet | 11 | 0.06 | 3.4e-03 | 7.0 | -6.5 | 8.3e-11 | -0.85 | 0.03 | 0.84 | FALSE |
6 | GTEx | Colon Transverse | CARF | 0.09 | 0.04 | enet | 12 | 0.03 | 1.1e-02 | -6.2 | -7.0 | 2.0e-12 | -0.89 | 0.04 | 0.86 | FALSE |
7 | GTEx | Esophagus Muscularis | CARF | 0.09 | 0.07 | enet | 20 | 0.10 | 1.4e-06 | 5.0 | -6.2 | 4.5e-10 | -0.84 | 0.03 | 0.96 | FALSE |
8 | GTEx | Heart Atrial Appendage | CARF | 0.09 | 0.02 | enet | 13 | 0.03 | 1.2e-02 | 7.3 | -6.4 | 1.7e-10 | -0.83 | 0.02 | 0.82 | FALSE |
9 | GTEx | Muscle Skeletal | ICA1L | 0.18 | 0.14 | lasso | 8 | 0.14 | 5.5e-14 | 3.5 | 5.3 | 1.2e-07 | 0.70 | 1.00 | 0.00 | FALSE |
10 | GTEx | Nerve Tibial | CARF | 0.08 | 0.07 | enet | 12 | 0.06 | 3.8e-05 | 6.1 | -6.1 | 1.0e-09 | -0.87 | 0.02 | 0.98 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | CARF | 0.11 | 0.09 | lasso | 3 | 0.10 | 5.0e-09 | 7.3 | -6.8 | 7.8e-12 | -0.92 | 0.01 | 0.99 | FALSE |
12 | GTEx | Thyroid | CARF | 0.09 | 0.05 | enet | 26 | 0.07 | 3.2e-06 | 7.0 | -5.6 | 1.8e-08 | -0.77 | 0.04 | 0.96 | FALSE |
13 | METSIM | Adipose | CARF | 0.07 | 0.02 | lasso | 5 | 0.03 | 8.8e-06 | 6.9 | -6.7 | 2.1e-11 | -0.85 | 0.02 | 0.98 | FALSE |