Hub : Genes

ICA1L

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0890 0.0360 6.4e-05 0.064 0.045 0.046 0.053 0.057 3.0e-08 3.1e-06 2.3e-06 5.0e-07 1.9e-07
2 GTEx Adipose Subcutaneous 0.1080 0.0420 2.4e-04 0.063 NA 0.010 NA 0.033 7.1e-06 NA 4.8e-02 NA 9.9e-04
3 GTEx Cells Transformed fibroblasts 0.1490 0.0490 8.2e-06 0.111 NA 0.087 NA 0.092 1.1e-08 NA 4.7e-07 NA 2.3e-07
4 GTEx Muscle Skeletal 0.1788 0.0477 5.2e-12 0.145 NA 0.143 NA 0.144 4.5e-14 NA 6.5e-14 NA 5.5e-14
5 GTEx Nerve Tibial 0.1181 0.0434 1.0e-04 0.105 NA 0.095 NA 0.077 7.5e-08 NA 3.1e-07 NA 4.0e-06
6 GTEx Pancreas 0.1680 0.0680 1.6e-03 0.068 NA 0.094 NA 0.101 7.7e-04 NA 9.2e-05 NA 4.9e-05
7 GTEx Skin Not Sun Exposed Suprapubic 0.1010 0.0500 3.6e-03 0.017 NA 0.025 NA 0.030 3.9e-02 NA 1.5e-02 NA 8.8e-03
8 GTEx Thyroid 0.1070 0.0400 1.9e-04 0.111 NA 0.101 NA 0.096 7.9e-09 NA 3.8e-08 NA 7.9e-08
9 METSIM Adipose 0.1052 0.0375 6.4e-07 0.039 0.046 0.047 0.049 0.048 1.6e-06 1.5e-07 1.5e-07 6.7e-08 1.0e-07
10 ROSMAP Brain Pre-frontal Cortex 0.2026 0.0461 0.0e+00 0.151 0.184 0.189 0.177 0.171 6.6e-19 4.6e-23 9.5e-24 4.0e-22 1.9e-21
11 TCGA Colon Adenocarcinoma 0.0980 0.0550 3.6e-03 0.008 0.023 0.021 NA 0.020 1.1e-01 1.6e-02 2.2e-02 NA 2.4e-02
12 TCGA Kidney Renal Clear Cell Carcinoma 0.0536 0.0298 1.3e-03 0.018 0.017 0.016 NA 0.019 3.7e-03 4.4e-03 5.7e-03 NA 2.8e-03
13 TCGA Liver Hepatocellular Carcinoma 0.0900 0.0450 1.2e-03 0.044 0.034 0.033 NA 0.028 4.0e-03 9.6e-03 1.1e-02 NA 1.8e-02
14 TCGA Thyroid Carcinoma 0.0610 0.0290 5.9e-04 0.006 0.018 0.014 NA 0.010 7.9e-02 6.9e-03 1.3e-02 NA 3.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bipolar Disorder (2018) 1.3 2.0 4.3 -1.9 1.6 1.6 1.2 1.7 0.6 2.0 1.6 0.8 -2.1 1.0 0.8 0.3 1.0
Bipolar Disorder or Schizophrenia 0.1 0.3 1.3 -0.5 0.3 0.3 0.6 0.1 0.6 1.2 0.2 0.7 -0.2 0.3 0.8 1.0 0.5
Depressed Affect (Nagel 2018) 7.0 14.6 26.8 4.7 -4.7 -4.7 -3.2 -3.9 -2.7 -3.2 -4.6 -3.4 5.2 -3.8 -3.2 -1.5 -3.0
Depression (Nagel 2018) 2.7 4.0 7.9 2.2 -2.4 -2.4 -1.7 -1.7 -0.8 -1.4 -2.3 -2.8 2.3 -2.1 -2.1 -1.5 -1.4
Intelligence (Savage-Jansen 2018) 0.3 1.0 5.4 -1.1 1.0 1.1 -0.3 0.9 -0.7 -0.5 1.1 0.2 -2.3 0.4 -0.1 -1.2 -0.6
Neuroticism (Nagel 2018) 3.6 8.4 14.1 3.6 -3.4 -3.5 -2.1 -2.7 -2.1 -2.4 -3.5 -3.1 3.8 -2.5 -2.7 -1.6 -2.5
Schizophrenia (2018) 0.3 0.6 2.2 1.0 -1.0 -0.9 -0.3 -1.2 0.2 -0.1 -1.0 0.2 1.5 -0.5 0.3 1.0 -0.2
Schizophrenia vs Biploar Disorder 5.7 7.5 15.8 3.6 -3.3 -3.4 -2.4 -3.4 -0.9 -2.1 -3.3 -1.8 4.0 -2.6 -2.0 -0.6 -2.2
Worry (Nagel 2018) 0.6 1.2 4.8 1.6 -1.3 -1.4 -0.2 -0.6 -0.1 -0.9 -1.3 -1.3 2.2 -0.2 -0.7 -0.2 -0.5
Alzheimer’s Disease (in mother) 1.2 1.4 2.5 1.1 -1.3 -1.3 -1.2 -1.1 -0.0 -1.4 -1.3 -1.6 0.7 -1.2 -1.3 -1.2 -1.1
Alzheimer’s Disease (in father) 11.7 12.7 17.6 3.9 -3.6 -3.7 -4.2 -3.5 -3.3 -3.9 -3.7 -3.4 2.3 -4.1 -3.6 -2.6 -3.5
Alzheimer’s Disease (including proxy) 9.5 13.7 18.6 3.9 -3.8 -3.9 -3.9 -3.5 -2.5 -4.3 -3.9 -4.2 2.5 -4.0 -3.9 -3.1 -3.8
Crohns Disease (2017) 1.7 3.8 8.4 -2.2 2.2 2.2 1.5 2.0 1.7 2.6 2.2 1.7 -2.9 1.6 1.2 0.2 1.8
Irritable Bowel Disease (IBD) 0.6 1.3 4.6 -1.2 1.1 1.1 0.6 0.9 1.0 2.1 1.1 1.3 -1.6 0.6 0.8 0.4 1.1
Ulcerative Colitis (UC) 0.1 0.2 0.8 0.3 -0.4 -0.4 -0.5 -0.5 -0.0 0.9 -0.4 0.3 0.2 -0.7 -0.1 0.2 -0.1
Major Depression (MDD) 0.6 0.8 1.3 1.0 -1.0 -1.0 -1.1 -0.9 0.0 -1.1 -1.0 -1.0 0.9 -1.0 -0.6 0.2 -0.5
Reaction Time 1.2 2.3 8.0 -1.6 1.7 1.6 1.1 1.6 2.8 1.6 1.7 0.7 -2.0 1.3 0.6 -0.3 0.8
Verbal and Numeric Reasoning (VNR) 0.4 1.0 3.9 -1.2 1.2 1.2 -0.0 1.1 -1.0 -0.0 1.2 0.9 -2.0 0.5 0.4 -0.5 -0.2
Breast Cancer 1.7 4.1 11.0 -1.4 1.7 1.7 1.5 1.5 1.1 1.0 1.7 2.6 -0.9 1.8 3.1 3.3 2.9
Ovarian Cancer 4.7 6.2 9.0 -2.8 2.7 2.8 2.0 2.5 3.0 2.8 2.7 1.9 -2.5 2.3 2.5 1.8 2.1
Prostate Cancer 0.5 0.8 1.6 1.2 -1.1 -1.1 -0.6 -1.0 -1.2 -0.8 -1.1 -0.3 1.2 -0.7 -0.3 0.1 -0.3
Age at First Birth 2.0 2.8 5.1 -1.6 1.9 1.8 2.0 2.1 1.8 0.9 1.8 1.5 -1.3 2.3 1.7 0.8 1.5
Bipolar Disorder (2011) 2.7 2.6 5.0 -2.0 2.0 2.1 1.4 1.9 0.6 1.0 2.0 1.1 -2.2 1.5 1.4 0.6 1.5
Body Mass Index (BMI) (2010) 3.9 5.3 8.5 2.3 -2.4 -2.4 -2.9 -2.3 -1.4 -2.1 -2.4 -2.5 1.2 -2.9 -2.5 -2.1 -2.4
Coronary Artery Disease (CAD) 26.8 32.0 43.7 -6.4 6.6 6.6 6.4 6.1 4.1 4.3 6.4 5.6 -5.0 6.6 5.3 3.5 5.3
Crohns Disease (2012) 0.7 1.2 5.4 -0.9 1.0 0.9 0.4 0.8 2.3 2.1 1.0 0.5 -1.2 0.4 0.4 -0.3 0.6
Mean Putamen Volume 1.0 1.2 3.8 0.9 -0.6 -0.7 -0.8 -0.4 -0.5 -2.0 -0.6 -1.5 0.0 -0.6 -1.5 -1.7 -1.2
Fasting Glucose 1.8 2.2 6.0 1.2 -1.5 -1.4 -1.5 -1.3 -2.4 -1.6 -1.4 -1.4 0.3 -1.4 -1.6 -1.5 -1.3
HbA1C 0.3 0.3 1.8 -0.4 0.1 0.1 -0.3 0.2 -0.2 0.2 0.1 -0.2 -0.8 -0.4 -0.9 -1.4 -0.5
HDL Cholesterol 0.3 0.5 2.5 0.5 -0.8 -0.7 -0.0 -0.4 0.2 -1.0 -0.7 -1.1 1.6 -0.2 -0.4 0.0 -0.4
LDL Cholesterol 7.1 11.2 19.2 2.7 -3.0 -3.1 -3.2 -2.8 -3.0 -3.8 -3.0 -4.3 0.8 -3.2 -4.3 -4.4 -3.6
Lupus 0.5 0.7 2.0 1.4 -0.9 -1.0 -1.4 -1.0 -0.7 0.1 -0.9 0.3 0.7 -0.9 -0.2 0.2 -0.7
Neuroticism (2016) 3.4 4.9 8.2 2.6 -2.7 -2.7 -2.6 -2.1 -0.9 -1.4 -2.7 -2.9 2.0 -2.4 -1.7 -1.4 -1.8
Primary Biliary Cirrhosis 0.9 1.3 3.3 1.3 -1.3 -1.3 -1.2 -1.6 -1.8 -0.1 -1.3 -0.4 1.1 -1.3 -0.4 0.2 -0.9
Rheumatoid Arthritis 0.9 1.2 2.5 1.0 -1.1 -1.1 -1.1 -1.3 -1.5 -1.6 -1.1 -1.0 0.7 -1.1 -1.0 -0.6 -1.0
Schizophrenia (2014) 0.3 0.7 3.1 0.4 -0.7 -0.6 0.0 -0.9 0.2 0.4 -0.7 0.8 1.5 -0.0 0.9 1.8 0.5
Triglycerides 3.2 5.3 8.9 1.9 -1.8 -1.9 -2.5 -1.8 -3.0 -2.6 -2.1 -2.8 0.1 -2.1 -2.8 -2.7 -2.7
Type 2 Diabetes (T2D) (2012) 5.0 5.7 10.9 2.5 -2.5 -2.4 -2.4 -2.4 -3.1 -3.3 -2.7 -1.6 2.4 -2.2 -1.8 -1.1 -2.2
Ulcerative Colitis 0.1 0.2 0.9 -0.1 -0.2 -0.1 -0.5 -0.6 -0.3 0.9 -0.2 0.1 -0.0 -0.7 -0.0 0.3 -0.1
Blood Eosinophil Count 2.3 17.5 30.8 4.5 -4.5 -4.5 -5.0 -4.1 -3.4 -2.1 -4.5 -5.5 2.5 -4.9 -4.3 -2.8 -4.3
Blood Platelet Count 2.2 25.8 51.4 3.6 -3.6 -3.5 -6.6 -3.5 -3.2 -5.0 -3.6 -7.1 -1.2 -5.5 -5.9 -7.2 -6.9
Blood Red Count 0.6 6.1 10.8 -2.9 2.8 3.0 2.4 2.2 1.1 1.0 2.8 3.3 -2.2 2.9 2.9 2.1 1.9
Blood White Count 1.0 7.2 10.6 2.9 -3.0 -3.0 -2.1 -3.3 -2.7 -1.9 -3.0 -2.8 3.0 -3.1 -2.7 -0.9 -2.1
Heel T-Score 2.0 16.2 54.8 -0.9 1.7 1.6 3.2 2.1 7.2 3.2 1.6 4.1 3.4 3.1 5.0 7.4 4.8
BMI 2.6 14.8 28.4 3.4 -3.5 -3.4 -4.9 -3.2 -5.3 -4.3 -3.4 -4.0 0.6 -4.1 -3.4 -4.0 -4.5
Height 1.5 29.0 95.1 -5.6 5.5 5.6 5.3 5.3 9.8 5.8 5.6 4.8 -3.3 5.0 3.8 2.2 4.4
Waist Hip Ratio (WHR) 0.7 3.2 9.0 1.3 -1.5 -1.6 -1.7 -1.0 -1.0 -0.8 -1.5 -2.9 -0.3 -1.7 -2.4 -3.0 -2.1
Systolic Blood Pressure 2.7 13.5 28.1 -3.6 3.5 3.5 5.3 3.3 1.3 3.7 3.5 4.5 -1.3 4.4 3.4 3.6 4.5
Smoking Status 6.5 15.5 29.2 4.1 -4.3 -4.4 -3.1 -3.8 -1.4 -2.8 -4.4 -4.2 3.8 -4.8 -5.4 -3.5 -3.5
Allergy or Eczema 2.1 5.5 9.1 3.0 -2.6 -2.6 -2.8 -2.7 -2.7 -1.4 -2.6 -2.3 2.8 -2.2 -0.9 0.8 -1.9
Cardiovascular Disease 0.9 2.8 10.2 1.2 -1.1 -1.2 -0.9 -1.2 -3.2 -2.0 -1.1 -1.7 0.3 -1.2 -2.4 -2.2 -1.8
Hypothyroidism (self reported) 0.3 0.8 3.6 -0.4 0.1 0.1 -0.0 0.4 -0.8 1.4 0.1 0.7 -0.6 -0.3 0.9 1.9 1.5
Respiratory disease 9.4 21.0 29.5 5.0 -5.0 -5.0 -5.4 -4.7 -3.1 -3.9 -5.1 -5.4 3.8 -5.4 -4.1 -2.4 -4.6
Type 2 Diabetes (T2D) (2018) 1.6 3.1 7.7 2.2 -2.1 -2.0 -1.6 -2.2 -2.8 -1.4 -2.1 -0.2 1.9 -1.7 -0.4 1.0 -0.5
Lung FEV1/FVC ratio 3.0 15.3 21.9 3.3 -3.8 -3.6 -4.6 -3.4 -4.5 -4.4 -3.7 -4.7 0.7 -4.0 -4.2 -4.3 -4.1
Lung FVC 3.0 15.5 23.1 -4.2 4.2 4.2 4.4 3.9 4.8 3.7 4.2 4.4 -2.4 4.4 3.4 2.2 3.6
Neuroticism 5.4 13.0 21.8 4.5 -4.3 -4.4 -2.6 -3.5 -2.6 -2.5 -4.3 -3.4 4.7 -3.2 -3.8 -2.3 -3.0
Chronotype (morning person) 0.6 1.4 6.8 -0.6 0.8 0.9 0.6 0.7 1.1 0.6 0.8 1.5 -0.0 0.7 2.0 2.6 1.4
Hair Pigment 0.0 0.8 2.2 0.8 -0.7 -0.6 -1.1 -0.5 0.1 -1.2 -0.7 -1.5 0.2 -0.8 -1.0 -1.1 -1.0
Tanning 0.2 2.0 8.2 1.4 -1.6 -1.6 -0.6 -1.3 0.7 0.7 -1.6 -0.6 2.9 -1.6 -1.7 -0.6 -0.7
Hand grip strength (left) 0.7 1.8 9.9 -0.6 0.4 0.4 1.5 0.4 3.1 0.4 0.4 1.9 1.3 0.6 0.8 1.6 1.6
Number of treatments/medications taken 1.9 3.5 8.0 1.9 -1.9 -1.9 -2.2 -1.8 -2.8 -1.6 -1.8 -2.0 0.8 -2.1 -1.7 -0.9 -1.7
Average weekly spirits intake 7.8 9.7 13.4 3.4 -3.7 -3.6 -3.2 -2.9 -1.3 -2.6 -3.6 -3.0 3.1 -3.5 -3.3 -2.5 -3.1
Sensitivity / hurt feelings 1.2 2.1 3.2 1.5 -1.8 -1.8 -1.0 -1.4 -0.5 -1.3 -1.8 -1.7 1.6 -1.3 -1.8 -1.3 -1.3
Frequency of depressed mood in last 2 weeks 6.6 9.3 14.8 3.7 -3.6 -3.7 -2.8 -3.1 -1.4 -2.1 -3.6 -3.1 3.8 -3.2 -3.1 -1.9 -2.3
Hearing difficulty/problems: Yes 1.0 1.5 5.0 0.4 -0.5 -0.5 -0.8 -0.2 -2.0 -1.6 -0.5 -1.2 -0.7 -0.8 -1.6 -2.2 -1.5
Relative age of first facial hair 0.8 1.7 7.7 1.3 -0.9 -1.0 0.5 -1.3 0.3 -0.3 -1.0 0.8 2.8 0.1 0.9 2.5 1.0
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 2.8 1.1 -1.3 -1.2 -1.7 -1.1 -1.1 -0.6 -1.2 -1.6 0.2 -1.3 -1.0 -0.7 -1.1
Ever used hormone-replacement therapy (HRT) 4.2 5.3 7.3 2.5 -2.4 -2.5 -2.2 -2.0 -1.7 -2.7 -2.5 -2.6 2.2 -2.5 -2.2 -1.5 -2.4
Ever had hysterectomy (womb removed) 2.3 2.6 4.4 1.7 -1.6 -1.6 -1.5 -1.6 -2.1 -1.6 -1.6 -1.4 1.5 -1.8 -1.8 -0.9 -1.7
Systolic blood pressure, automated reading 0.8 2.2 6.6 -1.4 1.3 1.2 2.6 1.4 1.0 1.2 1.4 1.8 0.1 1.7 1.1 1.6 1.9
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.0 0.5 -0.6 -0.6 -0.2 -0.4 -0.3 0.2 -0.6 0.9 0.6 -0.7 0.2 1.0 0.4
Angina 7.0 9.2 15.7 -3.6 3.6 3.5 3.2 3.9 1.9 3.1 3.6 2.2 -4.0 3.1 1.7 0.3 2.6
Medication for hormone replacement therapy 8.8 9.8 13.9 3.2 -3.4 -3.5 -3.2 -2.9 -3.1 -3.1 -3.5 -3.7 2.3 -3.4 -3.2 -2.1 -2.6
Vitamin and mineral supplements 1.8 2.4 4.7 -1.2 1.1 1.1 2.0 1.2 0.5 1.6 1.1 2.2 -0.2 1.9 1.7 1.9 2.1
Supplements: Zinc 0.3 0.3 1.4 -0.5 0.3 0.3 0.0 0.9 0.6 0.5 0.3 -0.2 -0.8 -0.2 -0.4 -1.2 -0.2
Medication: Co-codamol 0.3 0.3 1.1 0.7 -0.5 -0.6 -0.5 -0.1 0.3 -0.6 -0.5 -1.0 0.9 -0.3 -0.3 -0.1 -0.3
Medication: Metformin 1.9 2.7 4.8 2.0 -1.9 -1.9 -2.1 -2.2 -0.7 -1.6 -1.9 -1.2 1.5 -2.0 -1.0 -0.0 -1.4
Diabetes (father) 0.6 0.7 1.8 -0.8 0.9 0.9 1.0 1.0 -0.2 1.4 1.0 1.0 -0.6 0.8 0.4 0.1 0.5
Diabetes (mother) 2.3 3.0 5.3 2.2 -2.1 -2.1 -1.5 -2.0 -2.3 -1.3 -2.1 -1.0 2.3 -1.6 -0.6 0.6 -0.8
Severe depression (siblings) 0.2 0.2 0.7 -0.1 0.2 0.1 0.7 0.5 0.7 0.7 0.2 0.2 0.3 0.4 -0.2 0.1 0.8
Pack years adult smoking proportion 4.6 7.0 9.9 3.1 -3.1 -3.1 -3.1 -3.0 -2.4 -2.6 -3.1 -2.4 2.5 -3.0 -1.9 -1.0 -1.9
Impedance of leg (right) 0.1 0.4 4.2 0.2 -0.1 -0.1 0.3 -0.0 2.0 -0.2 -0.1 -0.4 1.0 -0.0 -0.4 0.0 0.4
Leg fat-free mass (left) 0.1 0.7 2.9 -1.1 1.0 1.1 0.3 1.0 0.2 0.6 1.0 0.9 -1.7 0.5 0.4 -0.7 0.2
Trunk fat percentage 1.9 7.6 12.6 2.6 -2.7 -2.7 -3.2 -2.3 -2.5 -3.1 -2.6 -3.5 1.2 -2.9 -2.7 -2.6 -2.9
Hand grip strength (right) 0.9 2.5 9.8 -0.8 0.8 0.9 1.7 0.4 3.1 0.5 0.8 2.2 1.0 1.0 1.6 2.5 1.9
Townsend deprivation index at recruitment 10.7 15.0 23.1 3.8 -4.0 -4.0 -4.0 -3.4 -3.4 -4.0 -4.0 -4.8 2.4 -3.8 -4.2 -3.9 -4.0
Current tobacco smoking 11.6 19.0 26.5 4.9 -4.8 -4.9 -4.5 -4.5 -2.2 -3.3 -4.8 -4.8 3.8 -5.2 -4.9 -3.5 -3.9
Average weekly fortified wine intake 0.1 0.1 0.3 -0.1 0.3 0.3 -0.5 -0.2 0.1 -0.5 0.2 -0.1 -0.3 0.0 0.4 0.5 -0.1
Maternal smoking around birth 4.0 5.8 10.1 2.9 -2.9 -2.9 -2.2 -2.7 -1.2 -2.2 -2.9 -2.3 3.2 -2.4 -2.1 -0.6 -1.6
Fed-up feelings 4.6 8.3 13.6 3.5 -3.6 -3.7 -2.5 -2.8 -2.8 -1.6 -3.6 -2.7 3.3 -3.0 -2.7 -1.2 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 4.0 5.3 10.6 2.3 -2.5 -2.5 -2.0 -2.0 -0.7 -1.2 -2.5 -3.3 1.9 -2.6 -3.1 -2.5 -1.9
Relative age voice broke 0.5 0.8 3.3 0.8 -0.5 -0.5 0.2 -0.8 1.8 0.2 -0.5 0.2 1.8 0.1 0.8 1.6 0.5
Taking other prescription medications 4.1 6.3 10.2 3.0 -2.9 -2.9 -3.2 -2.8 -2.4 -2.0 -2.9 -2.5 2.3 -2.9 -1.3 0.1 -2.1
Age when periods started (menarche) 3.7 8.8 27.3 -2.6 2.5 2.5 3.2 2.5 5.2 2.6 2.5 2.7 -0.8 2.8 2.8 3.3 3.6
Bilateral oophorectomy (both ovaries removed) 3.6 4.1 6.3 2.1 -2.2 -2.2 -1.8 -2.1 -2.1 -2.0 -2.1 -2.5 2.0 -1.8 -1.9 -1.3 -2.1
Heel bone mineral density (BMD) T-score, automated (left) 2.5 5.6 15.3 -1.1 1.2 1.1 2.1 1.7 3.5 2.2 1.2 3.1 1.2 1.8 2.9 3.9 3.2
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 2.9 0.9 -0.6 -0.7 -0.3 -0.8 -0.4 0.5 -0.6 0.4 1.2 -0.6 0.8 1.7 0.6
Qualifications: CSEs or equivalent 2.2 2.9 6.5 1.9 -1.8 -1.7 -2.5 -2.0 -2.5 -1.7 -1.8 -1.2 1.1 -1.9 -0.4 0.3 -1.5
Serious illness, injury or assault to yourself 0.6 0.7 1.2 1.1 -0.8 -0.8 -1.0 -0.7 -1.0 0.6 -0.8 -1.1 0.4 -1.0 -0.8 -0.7 -0.7
High blood pressure 0.3 0.8 1.6 -0.9 0.9 0.8 1.3 1.0 -0.9 -0.6 0.9 0.4 -1.1 0.8 -0.7 -1.2 0.1
Hayfever, allergic rhinitis or eczema 2.0 4.4 7.7 2.7 -2.4 -2.4 -2.3 -2.4 -2.7 -0.9 -2.4 -1.6 2.8 -2.0 -0.5 1.2 -1.4
Multivitamins +/- minerals 2.0 2.6 5.0 1.5 -1.4 -1.4 -2.2 -1.6 0.0 -1.9 -1.5 -2.2 0.9 -1.9 -1.2 -1.2 -2.0
Stomach or abdominal pain in last month 5.9 7.4 12.2 2.9 -2.9 -2.8 -3.5 -2.6 -1.1 -2.5 -2.8 -3.1 1.8 -3.0 -2.7 -2.0 -3.3
Supplements: Glucosamine 0.7 0.9 2.4 1.0 -1.0 -1.0 -1.5 -0.8 -1.0 -0.9 -1.0 -1.2 0.7 -1.2 -0.3 -0.1 -0.9
Diverticular disease/diverticulitis (self-reported) 11.5 13.7 24.8 3.3 -3.5 -3.4 -4.2 -3.3 -1.4 -3.7 -3.4 -4.8 1.8 -4.0 -4.2 -4.0 -5.0
Medication: Atenolol 6.6 8.3 16.3 -3.3 3.5 3.5 2.7 3.8 0.8 2.5 3.6 2.5 -4.0 3.0 1.8 0.3 2.1
Medication: Levothyroxine sodium 0.5 0.9 4.2 -0.4 0.3 0.3 0.3 0.8 -0.8 1.2 0.3 0.8 -0.4 0.0 1.2 2.0 1.5
Sitting height 3.3 23.6 28.9 -5.4 5.3 5.4 4.9 4.7 5.3 5.0 5.3 5.1 -3.6 4.8 4.5 3.5 4.7
Chronic bronchitis/emphysema (father) 5.0 5.9 9.5 2.6 -2.6 -2.6 -3.1 -2.1 -1.1 -2.1 -2.6 -3.0 1.8 -2.6 -2.2 -2.1 -2.6
High blood pressure (mother) 0.4 0.5 2.7 -0.3 0.4 0.4 0.4 0.3 -1.6 -0.2 0.4 0.7 -0.7 0.5 -0.6 -1.4 -0.4
Body mass index (BMI) 2.3 9.6 17.6 2.8 -2.8 -2.8 -3.8 -2.4 -4.2 -3.5 -2.8 -3.3 0.6 -3.3 -2.8 -3.3 -3.6
Impedance of leg (left) 0.1 0.7 4.8 0.6 -0.5 -0.6 -0.2 -0.4 2.2 -0.1 -0.5 -1.1 1.3 -0.4 -0.6 -0.1 0.1
Leg predicted mass (left) 0.1 0.7 2.8 -1.1 1.0 1.0 0.3 1.0 0.3 0.6 1.0 0.8 -1.7 0.5 0.3 -0.7 0.2
Trunk fat mass 1.2 5.0 8.4 2.0 -2.1 -2.1 -2.7 -1.7 -1.9 -2.5 -2.0 -2.9 0.6 -2.4 -2.4 -2.6 -2.6
Waist circumference 3.0 11.2 19.6 2.9 -3.0 -3.0 -4.1 -2.4 -3.3 -2.8 -3.0 -4.1 0.4 -3.6 -3.6 -4.4 -4.1
Number of incorrect matches in round 1.2 2.0 3.5 -1.4 1.5 1.5 1.4 1.4 1.5 1.9 1.5 1.2 -1.2 1.7 1.6 0.8 1.1
Past tobacco smoking 2.5 4.5 10.4 -2.1 2.4 2.4 1.0 1.7 0.7 1.8 2.4 1.8 -2.5 2.3 3.2 2.1 2.1
Alcohol usually taken with meals 3.5 5.7 9.1 -2.8 3.0 3.0 1.9 2.6 1.6 1.5 2.9 1.6 -2.9 2.7 2.5 1.8 1.7
Nervous feelings 0.2 0.4 2.0 0.8 -0.6 -0.7 0.4 -0.3 -0.6 0.0 -0.6 -0.2 1.4 0.3 -0.2 0.5 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.8 1.1 -1.1 -1.1 -0.8 -0.5 -1.1 -0.4 -1.0 -1.2 0.9 -1.0 -1.4 -1.2 -0.6
Hearing difficulty/problems with background noise 4.2 6.6 11.6 2.3 -2.4 -2.4 -2.8 -2.0 -2.4 -2.6 -2.5 -3.4 1.1 -2.5 -2.9 -3.0 -3.0
Hair/balding pattern: Pattern 2 0.6 0.7 3.2 0.6 -0.6 -0.6 -0.7 -0.4 1.8 -0.1 -0.6 -1.1 0.4 -1.2 -0.9 -1.1 -0.4
Had menopause 0.9 1.1 2.5 1.3 -1.2 -1.3 -0.8 -0.9 -0.5 -0.7 -1.2 -1.6 1.5 -1.2 -0.8 -0.1 -0.5
Had other major operations 0.7 0.9 2.7 -1.1 1.1 1.1 0.3 1.2 -0.8 1.0 1.1 0.5 -1.6 0.8 0.8 0.2 0.3
Forced vital capacity (FVC) 4.3 16.7 27.8 -4.0 4.0 4.0 4.3 3.1 5.3 4.4 3.9 5.1 -1.2 4.0 4.2 4.0 4.2
Heel bone mineral density (BMD) T-score, automated (right) 2.8 6.4 15.3 -1.4 1.6 1.6 2.1 1.9 3.5 2.0 1.6 3.6 0.4 2.3 3.4 3.9 3.3
Ever unenthusiastic/disinterested for a whole week 2.4 2.9 5.4 2.0 -2.0 -2.0 -2.0 -1.9 -0.3 -0.4 -2.1 -1.8 1.8 -2.3 -1.5 -0.6 -1.4
Qualifications: None of the above 1.6 3.5 5.5 2.0 -2.3 -2.3 -1.4 -2.0 -0.7 -0.8 -2.3 -2.0 2.3 -2.1 -2.3 -1.1 -1.2
Financial difficulties in last 2 years 2.5 3.3 5.0 2.2 -2.0 -2.0 -2.2 -1.8 -2.2 -1.8 -2.0 -1.4 1.4 -2.0 -1.2 -0.7 -1.6
Mouth/teeth dental problems 0.3 0.5 2.2 -0.9 0.7 0.7 1.5 0.3 0.1 -0.4 0.7 0.1 -0.5 1.0 -0.4 -0.3 0.7
Heart attack 13.0 16.6 24.8 -4.7 4.7 4.7 4.5 5.0 2.4 4.5 4.7 3.5 -4.8 4.3 2.7 0.6 3.6
Allergy 3.5 8.0 11.2 -3.3 3.2 3.2 3.2 3.0 3.1 1.5 3.2 3.0 -2.8 3.2 2.1 0.5 2.5
Pain all over the body in last month 0.7 0.8 3.4 -0.6 0.7 0.7 0.8 0.9 1.9 1.2 0.7 1.0 -0.2 0.6 0.5 0.7 0.9
Diabetes (self-reported) 1.3 2.0 3.5 1.8 -1.7 -1.7 -1.2 -1.7 -1.8 -0.9 -1.7 -0.1 1.9 -1.4 -0.4 1.2 -0.3
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 1.2 0.3 -0.1 -0.1 -0.3 0.1 -1.1 -0.6 -0.1 -0.3 -0.2 0.1 0.6 0.6 -0.1
Medication: Ramipril 1.9 2.4 5.3 -1.9 1.7 1.7 1.2 1.8 0.4 1.6 1.7 1.4 -2.3 1.3 0.9 0.6 2.0
Medication: Simvastatin 2.3 3.4 15.4 1.0 -1.1 -1.1 -1.1 -1.3 -3.9 -1.8 -1.1 -1.8 -0.4 -1.3 -2.7 -2.4 -1.8
Fluid intelligence score 0.2 0.5 2.2 -0.4 0.4 0.4 -0.6 0.0 -1.3 0.1 0.4 0.1 -1.5 -0.3 -0.3 -1.1 -0.9
Illnesses of siblings 1.3 1.9 6.5 -1.4 1.4 1.5 1.2 1.4 2.5 1.6 1.4 1.4 -0.7 0.9 0.8 0.4 1.2
Neuroticism score 4.8 9.9 14.8 3.8 -3.7 -3.8 -2.6 -2.9 -1.7 -2.6 -3.8 -3.3 3.9 -2.7 -3.2 -2.4 -2.8
Weight 0.2 1.0 3.2 0.6 -0.6 -0.6 -1.5 -0.4 -0.7 -0.9 -0.6 -1.2 -0.6 -1.2 -1.0 -1.8 -1.4
Impedance of arm (right) 0.7 3.4 8.9 2.0 -2.1 -2.1 -1.1 -2.2 -0.0 -1.1 -2.1 -2.3 3.0 -1.6 -1.9 -0.5 -1.3
Arm fat percentage (right) 4.6 18.2 26.4 4.1 -4.2 -4.2 -4.8 -3.8 -5.1 -4.5 -4.2 -4.8 2.0 -4.4 -4.1 -4.0 -4.7
Trunk fat-free mass 0.5 3.0 5.0 -2.1 2.0 2.1 1.3 1.9 2.0 1.7 2.0 1.9 -2.2 1.5 1.2 -0.0 1.1
Hip circumference 1.0 4.3 9.4 1.9 -1.9 -1.9 -3.1 -1.7 -1.9 -1.8 -1.9 -2.2 0.4 -2.5 -1.9 -2.3 -2.5
Time employed in main current job 1.8 2.0 7.0 -1.7 1.2 1.2 1.3 1.4 2.6 1.7 1.2 1.2 -0.8 1.2 1.1 0.8 1.6
Alcohol intake versus 10 years previously 1.4 2.2 7.7 0.9 -0.9 -0.9 -1.1 -0.9 -2.4 -1.0 -0.9 -1.3 -0.4 -1.2 -2.1 -2.8 -1.7
Father’s age at death 0.6 0.8 3.3 1.0 -1.0 -0.9 -0.5 -1.1 -0.2 -1.0 -1.0 0.0 1.8 -0.7 -0.1 0.2 -0.9
Worrier / anxious feelings 0.1 0.2 0.9 0.3 -0.1 -0.2 0.7 0.2 0.2 -0.1 -0.1 0.5 1.0 0.7 0.2 0.8 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 3.1 1.3 -1.3 -1.4 -1.2 -0.7 -1.7 0.3 -1.3 -1.8 0.8 -1.2 -1.4 -1.3 -0.8
Falls in the last year 8.0 10.9 18.1 3.4 -3.3 -3.4 -3.5 -3.0 -1.3 -1.9 -3.3 -4.2 2.1 -4.0 -4.1 -3.6 -3.5
Hair/balding pattern: Pattern 3 2.0 2.9 8.3 -1.1 1.4 1.4 1.4 1.4 -0.8 0.3 1.4 2.3 -0.5 2.1 2.8 2.9 1.7
Number of live births 0.1 0.2 1.1 -0.3 0.3 0.3 0.4 0.4 1.0 0.5 0.3 0.6 0.1 0.3 0.4 0.5 0.3
Forced expiratory volume in 1-second (FEV1) 2.4 8.1 14.1 -2.9 2.8 2.9 3.0 2.1 3.5 3.0 2.8 3.8 -1.0 2.8 2.9 2.6 2.9
Pulse rate 2.0 3.4 5.0 -1.8 1.9 1.9 1.1 1.9 1.8 1.6 1.9 1.7 -2.1 1.4 2.2 1.7 2.2
Happiness 0.9 1.1 2.5 1.2 -1.3 -1.3 -0.4 -1.4 -1.2 -0.4 -1.3 -0.3 1.6 -1.0 -1.0 -0.4 -0.3
Noisy workplace 4.2 5.2 12.0 1.6 -1.8 -1.8 -2.4 -1.7 -2.9 -2.3 -1.8 -2.5 0.2 -2.3 -2.9 -3.5 -2.5
Qualifications: A levels/AS levels or equivalent 0.5 1.2 3.3 -1.1 1.3 1.4 0.8 0.7 0.4 0.1 1.3 1.4 -1.4 1.8 1.0 -0.7 -0.1
Serious illness, injury or assault of a close relative in last 2 years 3.2 3.7 5.2 -1.9 2.2 2.1 2.0 2.0 0.7 1.7 2.2 2.0 -1.7 2.3 2.2 1.7 1.5
Mouth/teeth dental problems: Dentures 0.5 0.8 1.6 -0.7 1.0 1.0 0.2 1.3 1.2 1.2 1.0 0.9 -1.2 0.4 0.9 0.2 0.5
Asthma 5.9 11.7 16.3 4.0 -4.0 -4.0 -3.8 -3.4 -2.0 -2.5 -4.0 -4.0 3.5 -4.0 -2.8 -1.3 -3.1
Medication: Ibuprofen (e.g. Nurofen) 3.0 3.8 5.2 2.0 -2.1 -2.1 -2.1 -2.1 -1.8 -1.5 -2.1 -1.5 1.8 -2.3 -2.0 -1.5 -2.0
Medication: Cholesterol lowering 0.7 1.2 10.9 0.1 -0.2 -0.2 0.1 -0.3 -3.3 -1.2 -0.2 -0.6 -0.8 0.1 -1.2 -1.1 -0.4
Depression (self-reported) 0.2 0.2 0.7 0.6 -0.3 -0.3 -0.2 0.1 -0.1 -0.4 -0.3 0.1 0.9 0.1 0.5 0.8 0.4
Medication: Lansoprazole 0.4 0.4 0.9 0.6 -0.7 -0.6 -0.8 -0.9 -0.7 -0.7 -0.6 -0.6 0.6 -0.4 -0.5 -0.5 -0.9
Prospective memory result 0.9 1.1 2.4 -0.6 0.6 0.6 1.5 1.0 1.5 1.3 0.6 1.4 0.7 0.8 0.6 1.1 1.3
Lung cancer (father) 2.8 3.2 5.9 1.6 -1.8 -1.8 -2.3 -1.2 -2.2 -2.0 -1.8 -2.4 0.6 -2.2 -1.6 -1.3 -1.7
Illnesses of mother 0.2 0.2 1.3 -0.2 0.2 0.2 -0.2 -0.0 1.2 -0.0 0.1 0.1 0.2 -0.0 0.8 1.0 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 2.4 7.6 13.5 -2.9 2.9 3.0 2.7 2.3 3.4 2.6 2.9 3.7 -1.6 2.8 2.6 1.9 2.5
Pulse wave Arterial Stiffness index 1.6 1.8 2.9 1.7 -1.6 -1.7 -1.1 -1.5 -0.5 -0.7 -1.7 -1.0 1.7 -1.6 -1.2 -0.7 -1.4
Impedance of arm (left) 0.3 1.3 5.4 1.3 -1.2 -1.3 -0.4 -1.3 0.6 -0.6 -1.2 -1.4 2.3 -0.7 -0.8 0.5 -0.4
Arm fat mass (right) 2.0 8.2 11.8 2.6 -2.7 -2.7 -3.4 -2.3 -3.3 -3.0 -2.7 -3.2 0.9 -3.1 -2.8 -3.1 -3.3
Trunk predicted mass 0.5 2.9 4.8 -2.1 2.0 2.0 1.2 1.9 2.0 1.7 1.9 1.8 -2.2 1.4 1.1 -0.1 1.1
Standing height 1.8 18.2 53.1 -4.3 4.3 4.3 4.4 3.9 7.3 4.8 4.2 3.9 -2.2 4.0 3.3 2.7 4.1
Length of working week for main job 0.5 0.6 2.7 -0.4 0.6 0.5 0.2 0.6 -1.2 -0.5 0.5 -0.4 -1.0 0.1 -0.7 -1.6 -0.8
Exposure to tobacco smoke at home 8.0 9.0 13.5 2.7 -3.0 -2.9 -3.4 -3.3 -1.8 -2.5 -3.0 -3.7 1.8 -3.2 -3.5 -3.1 -3.1
Breastfed as a baby 0.1 0.2 0.6 -0.3 0.2 0.2 0.8 0.6 0.1 0.3 0.3 0.1 -0.0 0.5 -0.2 0.2 0.7
Tense / ‘highly strung’ 0.4 0.6 1.9 0.8 -0.7 -0.7 -0.2 -0.0 0.9 -0.6 -0.7 -1.0 1.4 -0.3 -0.9 -0.7 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.8 4.3 5.5 2.1 -2.1 -2.1 -2.3 -2.0 -2.2 -2.1 -2.1 -2.2 1.7 -2.0 -2.0 -1.7 -2.3
Hair/balding pattern: Pattern 4 1.0 2.5 13.9 1.2 -1.5 -1.4 -1.3 -1.3 -3.7 -1.0 -1.5 -1.1 0.1 -1.2 -1.5 -1.5 -1.6
Birth weight of first child 0.3 0.6 1.5 0.6 -0.8 -0.7 -0.6 -1.0 -0.1 -0.6 -0.8 -1.2 0.8 -0.4 -0.7 -0.4 -1.0
Peak expiratory flow (PEF) 0.5 1.1 4.6 -0.1 0.1 0.1 0.7 -0.6 1.6 0.6 0.1 1.3 1.3 0.4 1.3 2.1 1.1
Pulse wave reflection index 13.4 16.6 21.4 4.0 -4.4 -4.4 -3.7 -4.6 -3.4 -3.3 -4.4 -3.9 3.5 -4.4 -4.6 -3.7 -4.3
Ever highly irritable/argumentative for 2 days 1.5 1.8 4.2 1.4 -1.5 -1.5 -1.4 -1.8 -0.2 -0.6 -1.6 -0.7 1.7 -2.1 -1.2 -0.4 -1.1
Loud music exposure frequency 0.8 0.8 2.6 0.5 -0.9 -0.8 0.1 -0.8 -1.6 -0.8 -0.8 -0.3 0.7 -0.2 -1.4 -1.5 -0.8
Qualifications: O levels/GCSEs or equivalent 2.0 3.2 4.8 -1.8 2.2 2.2 1.8 1.8 1.9 0.9 2.2 1.8 -1.7 2.2 1.8 0.9 1.2
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.9 0.7 -0.8 -0.7 -0.9 -0.7 0.3 0.5 -0.7 -0.1 0.9 -0.9 0.2 0.3 -0.4
Blood clot in the leg (DVT) 0.6 0.8 1.9 -1.0 0.7 0.8 1.0 0.4 1.2 1.4 0.8 0.8 -0.3 0.8 0.8 0.7 1.0
Medication: Paracetamol 6.1 10.1 17.4 3.1 -3.3 -3.3 -3.6 -2.8 -4.2 -3.0 -3.3 -3.2 1.5 -3.6 -3.4 -2.5 -3.1
Headache pain in last month 8.5 14.6 20.0 4.5 -4.4 -4.3 -4.4 -4.4 -2.3 -4.2 -4.4 -3.4 3.9 -4.0 -2.8 -1.3 -3.7
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 3.8 1.0 -0.9 -0.9 -1.0 -0.7 2.0 0.2 -0.9 -0.6 1.6 -1.0 0.2 0.5 -0.4
Glaucoma (self-reported) 2.2 2.6 4.8 -1.8 1.8 1.9 1.2 1.5 2.2 2.2 1.8 1.0 -1.9 1.6 1.0 0.4 1.3
Gout (self-reported) 0.7 0.9 4.8 0.6 -0.7 -0.7 -1.1 -1.1 -2.2 -0.8 -0.7 -0.7 -0.5 -0.6 -0.5 -0.7 -1.0
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 4.7 -0.8 0.5 0.5 0.3 0.9 -0.3 1.3 0.6 0.9 -0.9 -0.0 1.4 2.2 1.8
Medication: Amlodipine 0.8 1.2 6.7 0.4 -0.3 -0.3 -0.4 -0.6 -0.7 -0.5 -0.3 -0.7 -0.4 -0.8 -2.0 -2.6 -1.6
Medication: Ventolin 100micrograms inhaler 3.8 4.9 6.6 2.3 -2.4 -2.5 -2.3 -2.3 -0.8 -2.1 -2.5 -2.4 1.8 -2.6 -2.3 -1.6 -2.3
Birth weight 0.6 1.2 6.5 0.4 -0.4 -0.4 -1.0 0.1 -0.5 -0.7 -0.4 -1.5 -0.5 -0.6 -1.5 -2.5 -1.7
Chronic bronchitis/emphysema (mother) 4.5 5.3 11.2 2.0 -1.7 -1.8 -2.3 -1.5 -2.5 -1.2 -1.7 -2.9 0.3 -2.6 -3.3 -3.2 -2.9
High blood pressure (siblings) 1.2 1.8 5.0 1.3 -1.4 -1.4 -1.0 -1.3 -2.2 -1.5 -1.3 -1.2 0.8 -1.0 -1.3 -1.1 -1.2
Forced vital capacity (FVC), Best measure 4.5 16.3 26.2 -4.2 4.2 4.2 4.2 3.5 5.0 4.2 4.2 5.1 -2.1 4.0 3.7 2.9 3.9
Body fat percentage 2.7 10.7 15.8 3.1 -3.2 -3.2 -3.9 -2.7 -3.4 -3.7 -3.1 -4.0 1.3 -3.5 -3.3 -3.2 -3.6
Leg fat percentage (right) 4.1 14.7 21.2 3.4 -3.5 -3.5 -4.5 -2.9 -4.2 -4.4 -3.4 -4.6 1.0 -4.0 -4.0 -4.3 -4.3
Arm fat-free mass (right) 0.7 3.7 7.2 -2.3 2.2 2.3 1.3 2.3 2.1 1.6 2.3 1.9 -2.7 1.5 1.4 0.0 1.3
Exposure to tobacco smoke outside home 3.2 4.3 8.0 1.7 -1.9 -1.8 -2.7 -1.8 -2.7 -1.6 -1.8 -2.8 0.2 -2.4 -2.0 -2.1 -2.2
Comparative body size at age 10 0.9 2.4 5.0 -1.5 1.7 1.7 1.5 1.1 -0.5 -0.4 1.7 2.1 -0.9 2.0 2.2 1.7 1.0
Number of full brothers 2.9 3.7 7.6 1.9 -2.0 -2.0 -2.0 -1.9 -1.9 -0.9 -2.0 -2.8 1.1 -2.0 -2.3 -1.7 -1.8
Worry too long after embarrassment 2.3 3.9 8.2 1.8 -1.9 -2.0 -1.3 -1.6 -1.2 -1.3 -2.0 -2.6 1.4 -1.6 -2.9 -2.8 -2.4
Seen a psychiatrist for nerves, anxiety, tension or depression 2.3 3.0 4.2 1.9 -1.8 -1.8 -2.0 -1.8 -2.0 -1.9 -1.9 -1.4 1.7 -2.0 -1.4 -0.7 -1.6
Wheeze or whistling in the chest in last year 10.0 17.8 21.4 4.6 -4.6 -4.6 -4.5 -4.3 -3.8 -3.4 -4.6 -4.2 3.5 -4.6 -4.2 -3.1 -4.6
Number of children fathered 0.3 0.3 1.8 -0.3 0.3 0.3 -0.4 0.5 -0.0 -1.4 0.3 -0.7 -0.9 0.2 -0.1 -0.6 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.7 3.8 -1.3 1.6 1.5 1.2 1.9 0.5 0.8 1.6 0.6 -1.5 1.6 1.4 0.8 0.5
Age at first live birth 1.9 3.4 5.8 -2.4 2.1 2.2 1.5 1.7 2.4 1.7 2.1 2.0 -2.4 1.7 0.7 -0.3 0.8
Pulse wave peak to peak time 2.3 2.7 4.2 -2.0 2.0 2.0 1.4 1.8 1.1 1.0 2.0 1.2 -1.9 1.9 1.4 0.8 1.6
Health satisfaction 0.9 1.1 5.5 0.6 -0.8 -0.8 -1.0 -1.1 -2.3 -0.4 -0.8 -1.2 0.0 -0.7 -1.0 -1.3 -1.1
Shortness of breath walking on level ground 2.1 2.5 4.5 1.6 -1.6 -1.6 -1.3 -1.4 -0.8 -1.7 -1.6 -2.1 1.1 -1.6 -1.8 -1.5 -1.8
Qualifications: College or University degree 0.7 2.3 3.3 -1.7 1.8 1.8 1.4 1.7 1.6 0.7 1.8 1.7 -1.6 1.6 1.3 0.6 1.2
Eye problems/disorders: None of the above 0.9 1.0 5.5 0.7 -0.2 -0.3 0.3 -0.3 -0.8 0.0 -0.3 0.4 1.6 0.6 1.7 2.3 1.0
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.7 -0.3 0.4 0.3 0.0 0.6 -0.7 0.4 0.4 0.2 -0.5 -0.2 -0.4 -0.9 -0.2
Emphysema/chronic bronchitis 3.8 4.3 10.4 1.9 -1.8 -1.9 -2.1 -1.5 -1.3 -1.1 -1.8 -2.1 0.5 -2.6 -3.0 -3.2 -2.6
Medication for pain relief, constipation, heartburn 3.5 6.0 8.1 -2.5 2.4 2.5 2.4 2.2 2.6 2.7 2.4 2.6 -1.6 2.4 2.8 2.4 2.6
Neck or shoulder pain in last month 1.4 2.0 3.3 1.7 -1.6 -1.5 -1.8 -1.3 -1.7 -1.8 -1.5 -1.4 1.4 -0.9 -0.1 0.2 -1.1
Medication: Blood pressure 3.8 6.7 10.0 -3.1 3.0 3.0 3.2 3.1 -0.1 2.0 3.0 2.8 -3.1 2.8 1.3 0.3 2.4
Angina (self-reported) 7.1 9.3 14.7 -3.6 3.6 3.5 3.2 3.8 1.8 3.1 3.6 2.4 -3.8 3.2 1.9 0.6 2.7
Migraine (self-reported) 7.7 9.6 13.5 3.4 -3.5 -3.5 -3.6 -3.0 -0.9 -2.3 -3.5 -3.7 2.2 -3.7 -3.4 -2.6 -2.9
Medication: Ibuprofen 2.5 3.0 4.0 2.0 -1.9 -1.9 -1.8 -2.0 -1.2 -1.5 -1.9 -1.4 1.8 -2.0 -1.8 -1.2 -1.7
Medication: Allopurinol 0.3 0.4 3.1 -0.3 0.2 0.3 -0.1 -0.1 -1.8 0.1 0.3 0.5 -1.1 0.4 0.7 0.3 0.0
Medication: Omeprazole 0.3 0.3 1.6 -0.3 0.2 0.2 0.0 0.5 0.3 -0.9 0.2 -0.5 -0.3 0.3 -0.6 -1.3 -1.0
Medication: Seretide 50 evohaler 1.7 2.0 3.6 1.6 -1.4 -1.4 -1.5 -1.2 -0.9 -0.1 -1.3 -1.6 1.2 -1.9 -1.9 -1.1 -1.7
Mean time to correctly identify matches 1.1 2.1 7.5 -1.3 1.6 1.5 1.1 1.6 2.7 1.3 1.6 1.0 -1.4 1.4 1.2 0.6 1.0
Heart disease (mother) 2.5 3.0 4.1 -1.8 1.9 1.9 1.7 1.6 -0.1 1.6 2.0 1.9 -1.9 2.0 2.0 1.0 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.4 7.3 1.2 -1.4 -1.4 -0.1 -1.4 -0.2 -0.7 -1.3 0.1 2.7 -0.9 -0.5 1.0 0.2
Whole body fat mass 1.3 5.6 8.4 2.1 -2.2 -2.2 -2.9 -1.9 -2.3 -2.6 -2.2 -2.8 0.6 -2.6 -2.5 -2.7 -2.7
Leg fat mass (right) 2.0 7.6 12.7 2.3 -2.3 -2.3 -3.4 -2.0 -3.0 -3.2 -2.3 -3.1 0.2 -3.0 -2.9 -3.6 -3.2
Arm predicted mass (right) 0.9 4.6 7.7 -2.5 2.5 2.5 1.6 2.5 2.2 1.8 2.5 2.3 -2.8 1.8 1.7 0.3 1.6
Pulse rate, automated reading 0.4 1.3 4.3 -1.3 1.3 1.3 0.5 1.5 0.9 0.9 1.3 0.4 -2.1 0.7 1.0 0.6 1.2
Alcohol intake frequency. 1.8 4.2 8.7 2.2 -2.0 -2.0 -3.0 -2.0 -2.8 -1.7 -2.0 -1.9 0.7 -2.3 -1.4 -1.5 -2.3
Comparative height size at age 10 0.3 1.7 8.5 -1.5 1.4 1.4 0.9 1.2 2.9 1.6 1.4 0.3 -1.1 0.7 0.1 -0.4 0.5
Number of full sisters 7.6 9.3 14.3 2.9 -3.2 -3.2 -2.9 -2.6 -3.1 -2.5 -3.2 -3.2 1.9 -3.2 -3.8 -3.7 -2.9
Suffer from ‘nerves’ 1.7 2.7 4.9 2.1 -1.9 -1.9 -1.5 -1.3 -0.8 -1.6 -1.9 -2.2 1.8 -1.4 -1.6 -1.2 -1.4
Overall health rating 2.4 5.1 10.5 1.9 -2.0 -2.0 -2.5 -1.5 -2.4 -1.7 -1.9 -3.0 0.6 -2.0 -2.8 -3.2 -2.6
Chest pain or discomfort 0.9 1.2 2.5 1.2 -1.0 -1.1 -1.4 -0.9 -0.4 -0.6 -1.0 -1.6 0.3 -1.1 -1.2 -1.3 -1.4
Had major operations 0.3 0.4 1.5 0.3 -0.4 -0.3 -0.9 -0.2 -0.3 -0.5 -0.3 -1.2 -0.3 -0.4 -0.5 -0.9 -1.1
Age at last live birth 2.0 2.9 4.6 -2.1 2.1 2.1 1.8 1.9 2.0 0.9 2.0 1.7 -2.0 1.9 1.0 0.0 0.9
Family relationship satisfaction 0.4 0.5 1.3 0.8 -0.9 -0.9 -0.4 -0.8 -0.0 0.3 -0.9 -0.5 1.1 -0.8 -0.5 -0.1 -0.2
Leg pain on walking 0.1 0.1 0.9 -0.2 0.0 0.0 0.2 -0.2 0.2 0.9 0.1 -0.3 -0.1 -0.1 -0.0 0.2 0.4
Qualifications: NVQ or HND or HNC or equivalent 2.1 2.5 5.5 2.0 -2.1 -2.1 -1.3 -1.6 -1.2 -1.4 -2.1 -1.3 2.3 -1.3 -0.7 0.2 -0.7
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.2 -1.0 1.1 1.1 0.6 0.9 0.4 0.3 1.2 0.5 -1.5 1.1 1.1 0.1 0.5
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.9 -1.1 0.8 0.8 1.4 0.5 0.9 -0.2 0.8 0.8 -0.3 1.0 0.3 0.4 0.8
Medication: Aspirin 1.2 1.6 2.7 -1.5 1.5 1.5 1.4 1.4 1.1 1.1 1.5 0.8 -1.6 1.3 0.2 0.3 1.2
Supplements: Vitamin C 0.3 0.4 1.2 -0.7 0.6 0.6 0.2 0.3 0.0 1.1 0.6 0.2 -0.8 -0.1 -0.5 -1.0 -0.4
Knee pain experienced in last month 6.4 10.0 15.4 3.3 -3.3 -3.4 -3.3 -2.9 -2.1 -2.7 -3.3 -3.9 2.3 -3.6 -3.4 -2.8 -3.4
Hypertension (Self-reported) 0.5 1.5 2.9 -1.3 1.5 1.4 1.7 1.6 -0.8 -0.1 1.4 0.6 -1.6 1.3 -0.4 -1.2 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.0 4.7 9.9 2.0 -2.0 -1.9 -2.6 -1.8 -0.7 -2.3 -1.9 -2.0 1.0 -2.1 -2.6 -3.0 -3.1
Illnesses of father: Heart disease 10.1 14.0 19.2 -4.1 4.3 4.3 3.8 4.2 1.0 2.8 4.4 3.8 -4.2 4.1 3.7 2.4 3.5
Illnesses of siblings: Diabetes 0.1 0.2 1.5 -0.2 0.1 0.1 -0.1 0.1 -1.2 0.4 0.1 0.1 -0.8 -0.2 -0.0 -0.1 0.0
Smoking status: Previous 0.2 0.3 1.4 0.1 -0.4 -0.4 0.7 0.1 0.2 -0.6 -0.4 0.0 0.7 -0.2 -1.2 -0.6 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.5 7.1 -2.2 2.3 2.3 1.8 2.0 2.7 1.5 2.2 1.8 -1.9 1.6 1.2 0.4 1.3
Whole body fat-free mass 0.4 2.1 4.7 -1.8 1.7 1.7 0.9 1.7 1.4 1.3 1.7 1.5 -2.2 1.1 0.9 -0.3 0.8
Leg fat-free mass (right) 0.2 0.8 2.6 -1.1 1.0 1.1 0.4 1.0 0.5 0.9 1.1 0.9 -1.6 0.6 0.6 -0.3 0.5
Arm fat percentage (left) 3.8 15.2 23.2 3.8 -3.8 -3.8 -4.5 -3.4 -4.8 -4.3 -3.7 -4.4 1.7 -4.0 -3.7 -3.6 -4.3
Average weekly red wine intake 2.0 3.0 5.2 -2.3 2.1 2.1 2.2 2.0 1.7 1.8 2.1 0.4 -2.1 1.5 0.1 -0.1 1.5
Handedness (chirality/laterality): Left-handed 0.6 0.8 1.5 -0.9 1.0 1.0 1.0 1.2 0.5 0.7 0.9 1.1 -1.1 0.8 0.4 -0.1 0.6
Mood swings 3.7 6.6 8.9 2.9 -2.9 -3.0 -2.2 -2.4 -2.3 -1.8 -3.0 -2.5 2.7 -2.6 -2.8 -2.0 -2.4
Loneliness, isolation 7.0 9.6 13.1 3.6 -3.6 -3.6 -3.4 -3.1 -1.7 -2.3 -3.6 -3.5 3.0 -3.2 -2.9 -2.3 -3.1
Long-standing illness, disability or infirmity 3.6 5.6 10.7 2.4 -2.4 -2.5 -2.9 -1.9 -2.3 -1.6 -2.4 -3.3 1.0 -2.7 -2.5 -1.9 -2.4
Ever had bowel cancer screening 0.8 0.9 3.5 1.1 -0.9 -0.9 -0.6 -1.3 0.8 -0.3 -0.9 -0.3 1.9 -0.4 0.3 1.4 -0.7
Diabetes diagnosed by doctor 1.1 1.9 3.6 1.7 -1.7 -1.6 -1.1 -1.6 -1.9 -0.9 -1.6 0.1 1.7 -1.4 -0.3 1.3 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 3.0 0.2 -0.4 -0.4 -1.0 -0.3 0.9 -1.1 -0.4 -1.4 -0.6 -0.9 -1.4 -1.7 -1.0
Friendships satisfaction 0.4 0.5 2.4 0.2 -0.3 -0.4 0.8 -0.3 0.9 0.6 -0.3 0.7 1.6 0.2 0.4 1.0 1.0
Qualifications: nursing, teaching 0.3 0.5 1.5 -0.8 0.9 0.9 0.7 0.3 -0.6 -0.0 0.8 1.2 -0.7 0.8 0.6 0.5 0.4
Commuting to job workplace: Walk 1.1 1.2 1.8 1.3 -1.3 -1.3 -1.0 -1.0 -0.8 -1.0 -1.4 -1.2 1.2 -1.1 -1.1 -0.4 -0.6
Eye problems/disorders: Cataract 1.2 1.4 8.6 -0.1 -0.3 -0.2 -0.4 -0.1 -0.6 -0.4 -0.2 -0.8 -1.1 -0.8 -2.2 -2.9 -1.7
Mouth/teeth dental problems: Mouth ulcers 1.3 2.1 3.5 1.7 -1.7 -1.6 -1.6 -1.6 -0.8 -0.9 -1.7 -0.7 1.9 -1.4 -1.0 -0.5 -1.9
Medication for cholesterol 2.0 3.0 6.7 -1.6 1.5 1.6 1.3 1.3 2.6 1.7 1.5 2.1 -0.7 1.6 2.3 2.0 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 3.2 1.5 -1.5 -1.5 -1.1 -1.6 0.8 -0.9 -1.5 -1.1 1.8 -1.2 -0.9 -0.2 -0.8
Back pain experienced in last month 1.4 2.0 3.7 1.6 -1.7 -1.6 -1.9 -1.4 0.4 -0.9 -1.6 -1.2 1.8 -1.7 -0.7 -0.4 -1.3
Mineral and other dietary supplements 2.3 3.1 6.7 -1.4 1.7 1.6 2.3 1.7 0.3 1.7 1.7 2.6 -0.9 2.2 1.9 1.6 2.0
Breast cancer (self-reported) 0.7 0.9 2.4 -1.2 1.0 1.0 1.1 1.1 -0.1 1.6 1.0 0.8 -0.9 0.8 0.2 0.1 0.9
Asthma (self-reported) 5.8 11.6 16.3 4.0 -3.9 -4.0 -3.9 -3.4 -1.9 -2.7 -3.9 -4.0 3.5 -4.0 -2.8 -1.2 -3.1
Osteoporosis (self-reported) 2.9 3.6 6.5 1.5 -1.6 -1.6 -2.5 -1.4 -1.2 -1.7 -1.7 -2.2 0.2 -2.3 -2.3 -2.5 -2.2
Osteoarthritis (self-reported) 6.7 8.7 13.9 2.9 -3.0 -3.0 -3.5 -2.4 -3.3 -2.2 -3.0 -3.7 1.3 -3.2 -2.8 -2.8 -3.3
Medication: Aspirin 1.2 1.6 2.4 -1.5 1.5 1.5 1.5 1.4 0.8 1.2 1.5 1.0 -1.5 1.3 0.4 0.6 1.4
Medication: Gliclazide 0.9 1.0 2.6 1.2 -1.2 -1.1 -1.0 -1.6 -0.6 -0.5 -1.2 -0.2 1.3 -1.0 -0.1 0.9 -0.4
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 -0.4 0.2 0.2 0.4 0.2 0.3 0.4 0.1 0.1 0.0 0.1 -0.1 0.1 0.4
Smoking status: Current 10.9 17.3 24.5 4.6 -4.5 -4.6 -4.3 -4.2 -2.1 -3.0 -4.5 -4.7 3.4 -4.9 -4.9 -3.7 -3.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.4 0.3 -0.4 -0.4 -0.6 -0.5 0.2 -0.1 -0.4 -0.1 0.6 -0.6 -0.4 -0.2 -0.3
Whole body water mass 0.4 2.3 4.8 -1.9 1.8 1.8 1.0 1.8 1.4 1.5 1.8 1.6 -2.2 1.2 1.0 -0.2 0.9
Leg predicted mass (right) 0.2 0.8 2.6 -1.1 1.1 1.1 0.4 1.0 0.5 1.0 1.1 1.0 -1.6 0.7 0.7 -0.2 0.5
Arm fat mass (left) 1.7 6.9 10.6 2.4 -2.4 -2.4 -3.2 -2.1 -3.2 -2.8 -2.4 -2.9 0.6 -2.8 -2.6 -2.9 -3.0
Number of self-reported non-cancer illnesses 6.8 11.9 16.2 3.4 -3.4 -3.4 -4.0 -3.2 -3.4 -3.3 -3.4 -3.9 1.9 -3.7 -3.5 -3.1 -4.0
Average weekly champagne plus white wine intake 0.4 0.5 1.2 0.5 -0.4 -0.4 -0.9 -0.6 -0.9 -0.4 -0.4 -0.9 -0.1 -1.0 -0.9 -0.9 -1.1
Miserableness 8.6 15.0 24.1 4.8 -4.6 -4.7 -3.4 -3.9 -3.1 -3.1 -4.7 -3.2 4.9 -4.1 -3.5 -1.6 -3.0
Guilty feelings 10.1 15.2 19.4 4.2 -4.4 -4.4 -4.1 -3.8 -2.8 -2.8 -4.3 -4.0 3.0 -4.1 -4.2 -3.9 -4.0
Wears glasses or contact lenses 0.4 0.5 1.1 0.9 -0.8 -0.8 -1.1 -0.9 0.2 -0.8 -0.7 -0.7 0.5 -1.0 0.1 0.4 -0.2
Ever taken oral contraceptive pill 0.5 0.6 2.0 -0.9 0.7 0.7 0.4 0.5 1.3 1.4 0.7 0.3 -0.9 0.4 -0.4 -0.8 0.2
Hearing aid user 0.1 0.2 0.8 -0.2 0.0 0.0 0.5 0.2 -0.6 -0.1 0.0 -0.2 -0.2 -0.1 -0.9 -0.8 -0.1
Mother’s age at death 0.1 0.2 0.6 0.3 -0.1 -0.2 0.2 -0.4 0.5 0.6 -0.2 0.0 0.7 -0.0 0.3 0.8 -0.0
Financial situation satisfaction 0.6 0.7 4.0 0.6 -0.7 -0.7 -0.6 -0.8 -2.0 -0.5 -0.7 -0.6 0.3 -0.4 -0.8 -1.2 -0.7
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.3 -0.7 0.7 0.6 0.9 0.8 -0.5 0.8 0.7 -0.4 -1.1 0.5 -0.8 -1.1 0.2
Commuting to job workplace: Public transport 1.1 1.3 2.6 0.6 -0.9 -0.9 -1.2 -0.9 -0.6 -0.8 -0.9 -1.5 0.0 -1.5 -1.6 -1.2 -1.6
Eye problems/disorders: Glaucoma 1.1 1.4 5.7 -1.2 1.3 1.3 0.8 1.1 2.4 0.9 1.3 0.3 -1.5 1.1 0.4 -0.5 0.7
Medication: Blood pressure 0.7 1.3 3.0 -1.0 1.4 1.2 1.7 1.2 -0.1 1.2 1.4 1.0 -1.0 1.5 0.6 0.3 1.0
Pain type(s) experienced in last month: Hip pain 0.5 0.6 2.8 -0.1 0.4 0.4 0.1 0.4 0.9 0.6 0.4 0.2 0.3 0.7 1.5 1.7 0.7
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.9 -0.0 -0.2 -0.1 -0.4 -0.4 0.9 0.4 -0.1 -0.7 0.1 -0.5 -0.4 0.0 -0.1
High cholesterol (Self-reported) 10.7 18.9 39.4 3.8 -3.8 -3.8 -4.0 -3.6 -6.3 -5.2 -3.8 -4.8 1.5 -3.7 -5.0 -4.8 -4.9
Medication: Bendroflumethiazide 0.4 0.7 1.3 -0.8 1.1 1.0 1.0 0.8 -0.3 0.1 1.1 0.9 -1.1 1.1 0.5 -0.0 0.3
Medication: Paracetamol 3.1 4.8 9.1 1.9 -2.1 -2.1 -2.4 -1.7 -3.0 -1.9 -2.1 -2.2 0.3 -2.5 -2.7 -2.4 -2.2
Medication: Lisinopril 3.5 4.5 7.7 -2.0 2.2 2.2 2.8 2.3 1.4 1.7 2.2 2.3 -1.3 2.4 1.9 2.1 2.4
Medication: Atorvastatin 3.7 4.5 5.9 2.4 -2.2 -2.2 -2.1 -2.0 -2.4 -2.3 -2.2 -2.4 1.4 -1.9 -2.0 -1.8 -2.3
Illnesses of father: High blood pressure 4.1 5.0 6.9 2.6 -2.5 -2.5 -2.1 -2.6 -1.8 -2.1 -2.5 -1.9 2.2 -2.2 -2.3 -1.6 -2.2
Alcohol drinker status: Never 0.1 0.1 0.5 -0.0 0.2 0.2 -0.7 0.4 -0.7 0.0 0.2 0.0 -0.7 -0.1 0.2 -0.2 -0.2
Ever smoked 4.6 8.0 15.8 2.9 -3.1 -3.2 -1.8 -2.4 -1.2 -2.6 -3.2 -2.8 3.1 -3.1 -4.0 -2.8 -2.7
Basal metabolic rate 0.2 1.1 3.7 -1.4 1.2 1.3 0.4 1.3 0.9 0.9 1.2 1.0 -1.9 0.7 0.6 -0.6 0.4
Leg fat percentage (left) 4.8 17.4 26.1 3.9 -3.9 -3.9 -5.0 -3.5 -4.2 -4.5 -3.9 -5.1 1.4 -4.5 -4.2 -4.4 -4.7
Arm fat-free mass (left) 0.4 1.9 4.5 -1.7 1.6 1.7 0.9 1.7 1.5 1.2 1.6 1.2 -2.1 1.0 0.7 -0.6 0.7
Number of operations (self-reported) 0.1 0.2 0.4 -0.3 0.5 0.5 -0.0 0.6 -0.6 -0.1 0.4 -0.2 -0.6 0.4 0.1 -0.2 -0.4
Average weekly beer plus cider intake 0.9 1.3 8.3 0.2 -0.5 -0.5 -0.7 0.2 -0.9 -1.3 -0.5 -1.0 -0.7 -0.6 -1.5 -2.9 -1.3
Irritability 2.3 4.0 9.5 2.7 -2.5 -2.5 -1.6 -1.9 -0.8 -1.1 -2.4 -2.0 3.1 -1.5 -1.4 -0.8 -1.8
Risk taking 4.5 6.6 10.1 2.9 -2.8 -2.9 -2.4 -2.5 -0.7 -1.5 -2.8 -2.9 2.6 -3.1 -3.2 -2.1 -2.4
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.5 0.6 -0.6 -0.6 -0.4 -0.6 -0.1 -0.4 -0.6 -0.1 0.7 -0.4 -0.1 0.1 -0.4
Fractured/broken bones in last 5 years 2.5 3.2 9.7 1.1 -1.2 -1.2 -2.1 -0.9 0.0 -1.9 -1.2 -2.7 -0.3 -1.8 -2.1 -3.1 -2.3
Age started oral contraceptive pill 3.3 4.1 5.3 -2.3 2.3 2.3 2.0 2.2 1.5 1.9 2.3 1.6 -2.2 2.0 1.9 1.6 2.1
Diastolic blood pressure, automated reading 4.2 13.0 19.5 4.1 -4.2 -4.3 -3.0 -4.0 -2.4 -3.7 -4.2 -3.1 4.4 -4.1 -3.4 -1.5 -2.7
Ever depressed for a whole week 4.0 5.0 7.3 2.7 -2.7 -2.7 -2.5 -2.7 -1.1 -1.1 -2.7 -1.5 2.7 -2.7 -2.0 -1.2 -1.7
Unable to work because of sickness or disability 0.6 0.7 2.5 -0.6 0.9 0.8 0.6 0.9 0.0 1.6 0.9 0.8 -0.6 0.8 0.9 0.7 1.1
Commuting to job workplace: Cycle 1.3 1.6 2.4 1.2 -1.4 -1.3 -1.2 -1.2 1.1 -0.8 -1.4 -1.4 1.5 -1.4 -1.3 -0.9 -1.3
Myopia 0.6 0.8 2.8 -0.2 0.3 0.3 0.5 0.1 1.0 1.4 0.3 1.1 0.7 0.8 1.4 1.7 1.0
Vascular/heart problems diagnosed by doctor 0.9 2.4 5.5 1.9 -1.9 -1.9 -2.0 -2.0 0.2 -0.2 -1.9 -0.8 2.3 -1.5 0.3 1.4 -0.6
Cholesterol lowering medication 9.2 13.6 18.3 3.6 -3.5 -3.5 -3.8 -3.4 -3.9 -4.1 -3.5 -4.3 1.8 -3.7 -4.1 -3.7 -4.2
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.5 0.2 -0.2 -0.2 -0.5 -0.0 -0.9 -1.6 -0.2 -1.0 -0.0 -0.0 -0.7 -1.2 -1.4
Pain experienced in last month 4.3 7.1 12.1 -3.2 3.2 3.2 3.0 3.0 -0.0 2.4 3.2 2.5 -3.5 2.9 1.8 0.6 2.3
Supplements: Calcium 4.1 4.6 10.6 1.3 -1.6 -1.6 -2.5 -1.6 -1.3 -1.4 -1.6 -3.3 0.0 -2.4 -2.6 -3.1 -3.0
Basal cell carcinoma (self-reported) 0.3 0.4 2.3 0.3 -0.2 -0.1 -0.1 -0.7 1.5 -1.1 -0.1 -0.1 1.0 -0.0 0.4 0.6 -0.4
Heart attack/myocardial infarction (self-reported) 12.2 15.7 23.0 -4.5 4.5 4.5 4.3 4.8 2.1 4.5 4.5 3.5 -4.7 4.2 2.6 0.6 3.5
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.8 -1.1 0.8 0.8 1.2 0.5 1.3 1.7 0.9 1.1 -0.3 0.9 0.8 0.8 1.1
Heart disease (siblings) 2.4 2.9 7.5 -1.4 1.4 1.4 1.3 1.4 -0.3 1.5 1.5 1.6 -1.5 1.8 2.7 2.5 2.1
Alcohol drinker status: Previous 2.6 2.9 5.5 2.1 -1.9 -2.0 -1.6 -1.6 -0.9 -1.6 -1.9 -1.3 2.4 -1.8 -1.3 -1.0 -1.6
Pack years of smoking 3.7 5.5 7.8 2.7 -2.7 -2.7 -2.8 -2.6 -1.8 -2.3 -2.7 -2.3 2.1 -2.8 -1.8 -1.0 -1.6
Impedance of whole body 0.2 0.8 3.2 0.8 -0.8 -0.8 -0.1 -0.7 1.5 -0.4 -0.8 -1.2 1.8 -0.5 -0.7 0.2 -0.0
Leg fat mass (left) 2.2 8.6 13.6 2.6 -2.6 -2.6 -3.7 -2.3 -3.0 -3.2 -2.6 -3.5 0.5 -3.2 -3.0 -3.5 -3.4
Arm predicted mass (left) 0.2 1.3 3.3 -1.4 1.3 1.4 0.5 1.3 1.2 0.9 1.3 1.1 -1.8 0.7 0.7 -0.4 0.6