[Hub]/) : Traits : Systolic Blood Pressure : ← →

chr2:217,967,913-219,878,756

Best TWAS P=1.23e-15 · Best GWAS P=1.84e-14 conditioned to 3.19e-10

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PNKD	0.12	0.08	lasso	3	0.07	4.2e-06	6.1	-6.2	7.8e-10	0.01	0.98	0.01	FALSE
2	GTEx	Adipose Subcutaneous	TMBIM1	0.12	0.08	lasso	5	0.10	2.9e-08	6.1	-5.7	1.1e-08	0.01	0.99	0.01	FALSE
3	GTEx	Adipose Subcutaneous	ARPC2	0.16	0.16	enet	12	0.17	4.4e-14	5.0	-5.5	3.6e-08	-0.04	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	RP11-378A13.1	0.25	0.34	lasso	9	0.37	2.4e-31	6.1	-5.9	3.3e-09	0.00	0.99	0.01	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-378A13.1	0.30	0.28	enet	30	0.32	2.9e-17	5.1	-6.0	2.5e-09	0.00	1.00	0.00	FALSE
6	GTEx	Adrenal Gland	PNKD	0.20	0.16	lasso	5	0.19	1.6e-07	5.8	-5.6	2.1e-08	0.00	0.78	0.02	FALSE
7	GTEx	Adrenal Gland	RP11-378A13.1	0.25	0.22	enet	17	0.30	3.2e-11	6.0	-5.8	4.9e-09	0.00	0.99	0.01	FALSE
8	GTEx	Artery Aorta	TMBIM1	0.17	0.20	enet	29	0.19	1.2e-10	6.0	-6.1	1.3e-09	-0.01	0.99	0.01	FALSE
9	GTEx	Artery Aorta	RP11-378A13.1	0.28	0.28	enet	20	0.31	2.2e-17	5.0	-5.4	5.3e-08	-0.01	1.00	0.00	FALSE
10	GTEx	Artery Coronary	TMBIM1	0.22	0.08	lasso	1	0.03	3.6e-02	6.1	-6.1	1.3e-09	0.00	0.16	0.04	FALSE
11	GTEx	Artery Coronary	RP11-378A13.1	0.34	0.36	lasso	8	0.38	1.2e-13	6.0	-6.0	2.0e-09	0.00	0.99	0.01	FALSE
12	GTEx	Artery Tibial	TMBIM1	0.18	0.14	enet	30	0.13	3.2e-10	6.1	-5.2	1.5e-07	0.02	0.99	0.01	FALSE
13	GTEx	Artery Tibial	RP11-378A13.1	0.20	0.17	enet	13	0.24	7.6e-19	4.7	-6.0	2.6e-09	0.01	0.99	0.01	FALSE
14	GTEx	Brain Caudate basal ganglia	RP11-378A13.1	0.55	0.38	enet	17	0.52	4.0e-17	5.2	-5.4	8.0e-08	-0.01	1.00	0.00	FALSE
15	GTEx	Brain Cerebellum	RP11-378A13.1	0.46	0.52	enet	15	0.46	2.5e-15	5.0	-5.6	2.7e-08	-0.01	1.00	0.00	FALSE
16	GTEx	Brain Cortex	RP11-378A13.1	0.61	0.56	enet	23	0.61	6.7e-21	5.1	-5.5	3.4e-08	0.00	1.00	0.00	FALSE
17	GTEx	Brain Frontal Cortex BA9	RP11-378A13.1	0.38	0.54	enet	24	0.49	7.2e-15	5.1	-5.4	5.4e-08	0.00	1.00	0.00	FALSE
18	GTEx	Brain Hypothalamus	RP11-378A13.1	0.37	0.44	enet	17	0.45	5.6e-12	5.1	-5.2	2.2e-07	0.00	1.00	0.00	FALSE
19	GTEx	Breast Mammary Tissue	RP11-378A13.1	0.27	0.26	enet	20	0.30	1.3e-15	6.1	-5.9	3.5e-09	0.00	0.99	0.01	FALSE
20	GTEx	Breast Mammary Tissue (Male)	RP11-378A13.1	0.27	0.24	enet	29	0.27	5.4e-07	6.1	-5.4	5.5e-08	-0.07	0.50	0.04	FALSE
21	GTEx	Breast Mammary Tissue (Female)	ARPC2	0.12	-0.01	lasso	5	-0.01	7.1e-01	5.8	-5.9	3.8e-09	-0.04	0.08	0.11	FALSE
22	GTEx	Breast Mammary Tissue (Female)	RP11-378A13.1	0.30	0.11	lasso	10	0.22	3.0e-07	6.1	-5.7	1.1e-08	0.01	0.98	0.01	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	TMBIM1	0.35	0.24	lasso	10	0.24	2.3e-08	6.1	-5.8	5.3e-09	0.01	0.99	0.01	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	RP11-378A13.1	0.18	0.14	lasso	6	0.13	4.6e-05	6.2	-6.5	7.5e-11	-0.03	0.40	0.03	FALSE
25	GTEx	Cells Transformed fibroblasts	TMBIM1	0.15	0.25	lasso	3	0.27	2.2e-20	6.0	-6.2	7.0e-10	0.01	0.99	0.01	FALSE
26	GTEx	Cells Transformed fibroblasts	RP11-378A13.1	0.29	0.26	enet	24	0.31	2.0e-23	6.1	-5.3	1.3e-07	0.01	0.99	0.01	FALSE
27	GTEx	Colon Sigmoid	RP11-378A13.1	0.31	0.33	enet	23	0.34	6.0e-13	5.0	-5.5	3.9e-08	0.00	1.00	0.00	FALSE
28	GTEx	Colon Transverse	RP11-378A13.1	0.35	0.31	lasso	6	0.43	4.6e-22	6.0	-5.8	4.9e-09	0.00	0.99	0.01	FALSE
29	GTEx	Esophagus Mucosa	RP11-378A13.1	0.28	0.32	enet	27	0.39	1.3e-27	5.1	-5.2	1.5e-07	-0.01	1.00	0.00	FALSE
30	GTEx	Esophagus Muscularis	RP11-378A13.1	0.37	0.42	enet	21	0.41	6.9e-27	5.1	-5.2	1.9e-07	0.03	1.00	0.00	FALSE
31	GTEx	Heart Atrial Appendage	TMBIM1	0.11	0.09	lasso	2	0.08	1.8e-04	6.1	-6.2	5.5e-10	0.01	0.81	0.02	FALSE
32	GTEx	Heart Atrial Appendage	RP11-378A13.1	0.26	0.17	enet	13	0.22	2.0e-10	5.1	-5.7	1.1e-08	0.00	1.00	0.00	FALSE
33	GTEx	Heart Left Ventricle	TMBIM1	0.12	0.08	enet	11	0.07	1.4e-04	4.6	-5.6	1.7e-08	0.00	0.90	0.01	FALSE
34	GTEx	Heart Left Ventricle	RP11-378A13.1	0.21	0.16	enet	27	0.19	1.3e-10	6.0	-5.4	6.5e-08	0.00	1.00	0.00	FALSE
35	GTEx	Lung	ARPC2	0.19	0.10	lasso	7	0.09	1.6e-07	4.9	-5.1	2.9e-07	0.01	1.00	0.00	FALSE
36	GTEx	Lung	RP11-378A13.1	0.27	0.30	enet	19	0.37	2.3e-29	6.0	-6.0	2.1e-09	-0.02	0.99	0.01	FALSE
37	GTEx	Muscle Skeletal	TMBIM1	0.10	0.06	lasso	9	0.06	3.3e-06	6.1	-5.5	3.9e-08	0.01	0.99	0.01	FALSE
38	GTEx	Muscle Skeletal	ARPC2	0.23	0.17	enet	18	0.20	1.9e-19	5.8	-5.4	7.7e-08	-0.02	1.00	0.00	FALSE
39	GTEx	Muscle Skeletal	RP11-378A13.1	0.19	0.27	enet	23	0.31	1.7e-30	5.1	-6.0	1.9e-09	-0.03	1.00	0.00	FALSE
40	GTEx	Nerve Tibial	ARPC2	0.29	0.30	enet	27	0.26	1.1e-18	4.9	-5.3	1.1e-07	-0.06	1.00	0.00	FALSE
41	GTEx	Pancreas	RP11-378A13.1	0.29	0.14	enet	24	0.16	4.4e-07	5.1	-5.7	1.3e-08	-0.01	0.99	0.00	FALSE
42	GTEx	Pituitary	TMBIM1	0.20	0.16	enet	13	0.02	8.4e-02	5.1	-5.6	2.3e-08	0.00	0.37	0.04	FALSE
43	GTEx	Pituitary	RP11-378A13.1	0.64	0.52	enet	19	0.52	2.7e-15	5.1	-5.4	7.9e-08	0.01	1.00	0.00	FALSE
44	GTEx	Prostate	RP11-378A13.1	0.29	0.12	enet	14	0.10	2.1e-03	6.0	-5.3	1.2e-07	0.00	0.28	0.04	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	PNKD	0.28	0.28	enet	9	0.26	9.7e-15	5.8	-5.9	3.7e-09	0.01	1.00	0.00	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	RP11-378A13.1	0.26	0.25	lasso	8	0.28	5.6e-16	5.8	-6.0	2.1e-09	0.00	0.99	0.01	FALSE
47	GTEx	Skin Sun Exposed Lower leg	PNKD	0.27	0.29	lasso	8	0.34	3.9e-29	5.8	-6.0	2.0e-09	0.00	1.00	0.00	FALSE
48	GTEx	Skin Sun Exposed Lower leg	RP11-378A13.1	0.29	0.36	enet	28	0.40	9.8e-35	6.2	-5.1	3.0e-07	0.03	0.99	0.01	FALSE
49	GTEx	Small Intestine Terminal Ileum	RP11-378A13.1	0.39	0.17	enet	15	0.14	4.5e-04	5.0	-5.8	8.6e-09	0.02	0.36	0.07	FALSE
50	GTEx	Spleen	RP11-378A13.1	0.37	0.41	enet	27	0.41	1.2e-11	6.2	-6.1	9.7e-10	0.01	0.98	0.01	FALSE
51	GTEx	Stomach	RP11-378A13.1	0.32	0.32	enet	20	0.34	3.4e-17	6.1	-5.6	1.7e-08	-0.01	0.99	0.01	FALSE
52	GTEx	Testis	PNKD	0.20	0.19	lasso	3	0.19	1.2e-08	6.1	-6.2	6.4e-10	-0.01	0.98	0.01	FALSE
53	GTEx	Testis	TMBIM1	0.27	0.13	enet	20	0.15	2.7e-07	5.8	-8.0	1.2e-15	-0.05	0.96	0.01	TRUE
54	GTEx	Testis	RP11-378A13.1	0.37	0.18	enet	22	0.22	2.7e-10	6.1	-5.5	3.1e-08	0.00	0.99	0.01	FALSE
55	GTEx	Thyroid	PNKD	0.13	0.12	enet	13	0.14	6.3e-11	4.7	-5.6	1.7e-08	-0.02	1.00	0.00	FALSE
56	GTEx	Thyroid	RP11-378A13.1	0.31	0.34	enet	34	0.38	3.7e-30	5.1	-5.4	5.4e-08	0.00	1.00	0.00	FALSE
57	GTEx	Vagina	RP11-378A13.1	0.22	0.07	enet	11	0.03	7.1e-02	5.1	-5.6	2.0e-08	0.00	0.17	0.05	FALSE
58	GTEx	Whole Blood	PNKD	0.05	0.04	lasso	3	0.03	4.4e-04	5.1	-5.6	2.4e-08	0.00	0.69	0.01	FALSE
59	GTEx	Whole Blood	RP11-378A13.1	0.11	0.13	enet	18	0.15	1.6e-13	6.2	-6.2	4.7e-10	0.00	0.99	0.01	FALSE
60	METSIM	Adipose	TMBIM1	0.14	0.15	lasso	11	0.14	1.3e-20	6.1	-6.2	4.8e-10	0.02	0.99	0.01	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	RP11-378A13.1	0.44	0.64	bslmm	431	0.64	1.1e-107	5.0	-5.5	2.9e-08	-0.06	1.00	0.00	FALSE
62	YFS	Blood	GPBAR1	0.04	0.06	lasso	10	0.06	2.3e-18	5.1	5.2	2.3e-07	0.00	1.00	0.00	FALSE
63	YFS	Blood	TNS1	0.15	0.11	bslmm	547	0.12	8.3e-38	5.2	5.4	5.8e-08	0.20	1.00	0.00	TRUE
64	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PNKD	0.13	0.03	enet	7	0.06	9.8e-04	4.6	-5.4	8.3e-08	0.02	0.03	0.69	FALSE
65	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMBIM1	0.02	0.01	blup	49	0.02	2.6e-03	6.0	-6.0	2.1e-09	0.00	0.02	0.92	FALSE
66	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMBIM1	0.10	0.04	blup	49	0.06	3.0e-03	6.0	-6.5	1.1e-10	0.02	0.02	0.83	FALSE
67	The Cancer Genome Atlas	Soft Tissue Sarcoma	TMBIM1	0.07	0.04	blup	49	0.03	4.8e-03	5.9	-6.5	6.3e-11	0.02	0.03	0.71	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	TMBIM1	0.02	0.02	blup	49	0.02	9.3e-03	6.1	-6.5	6.7e-11	0.02	0.02	0.77	FALSE