Hub : Genes

TNS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1430	0.0400	6.8e-05	0.097	0.034	0.071	0.085	0.096	8.0e-12	4.6e-05	5.1e-09	1.6e-10	1.1e-11
2	METSIM	Adipose	0.0452	0.0219	7.8e-03	-0.002	0.010	-0.001	0.009	-0.001	7.4e-01	1.1e-02	4.0e-01	1.5e-02	5.8e-01
3	NTR	Blood	0.0345	0.0147	5.2e-03	0.003	0.004	0.001	0.005	0.003	3.3e-02	1.1e-02	1.6e-01	5.4e-03	2.2e-02
4	YFS	Blood	0.1519	0.0253	0.0e+00	0.109	0.105	0.114	0.122	0.111	1.3e-33	1.6e-32	2.2e-35	8.3e-38	2.4e-34
5	TCGA	Stomach Adenocarcinoma	0.1220	0.0510	6.4e-03	0.014	0.012	0.008	NA	0.001	3.0e-02	4.2e-02	8.0e-02	NA	2.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.3	2.8	1.0	0.3	1.5	0.4	-1.7
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	0.4	0.5	0.6	-0.0	-0.4
Depressed Affect (Nagel 2018)	0.3	0.5	1.7	1.3	-1.0	0.2	0.2	-0.2
Depression (Nagel 2018)	0.3	0.4	0.7	0.7	-0.7	0.7	-0.2	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.8	2.3	0.4	1.5	-0.2	0.7	0.9
Neuroticism (Nagel 2018)	0.2	0.4	1.7	1.3	-0.5	-0.0	-0.3	-0.3
Schizophrenia (2018)	0.1	0.3	0.9	-0.3	0.5	-0.4	-0.3	0.9
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	-1.2	-0.8	0.5	0.1	0.7
Worry (Nagel 2018)	0.2	0.4	1.1	-0.5	0.3	-1.0	-0.7	-0.0
Alzheimer’s Disease (in mother)	0.1	0.2	0.5	-0.2	-0.7	0.2	0.1	-0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.6	0.0	-0.6	-0.2	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	1.3	-0.8	-0.7	0.0	0.3	-1.1
Crohns Disease (2017)	1.4	3.0	10.1	-0.1	1.2	1.6	1.0	-3.2
Irritable Bowel Disease (IBD)	0.8	1.9	3.8	-0.0	1.5	1.9	0.6	-1.8
Ulcerative Colitis (UC)	0.4	0.8	2.1	0.2	1.4	1.3	-0.0	0.4
Major Depression (MDD)	1.0	1.2	4.1	-0.2	-2.0	1.1	-0.2	-0.7
Reaction Time	0.2	0.5	2.2	-1.5	0.1	0.3	0.1	-0.1
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.8	0.9	-0.5	-0.6	1.9	0.3
Breast Cancer	0.4	0.9	2.3	1.5	-0.6	1.0	-0.9	0.1
Ovarian Cancer	0.3	0.4	0.8	-0.4	-0.9	0.7	-0.5	0.4
Prostate Cancer	0.1	0.2	0.5	0.3	0.7	-0.3	-0.5	-0.1
Age at First Birth	0.1	0.1	0.3	-0.1	0.5	-0.1	0.5	-0.1
Bipolar Disorder (2011)	0.6	0.6	1.2	1.1	1.1	0.7	0.5	0.0
Body Mass Index (BMI) (2010)	2.0	2.8	3.8	-1.4	1.4	1.6	2.0	-1.9
Coronary Artery Disease (CAD)	2.8	3.4	8.2	2.9	-2.3	-0.1	0.9	1.6
Crohns Disease (2012)	0.9	1.4	5.7	-0.2	0.3	0.1	1.1	-2.4
Mean Putamen Volume	0.4	0.5	0.9	1.0	0.2	0.9	0.8	-0.0
Fasting Glucose	0.1	0.1	0.4	0.3	-0.1	-0.2	-0.6	-0.3
HbA1C	2.4	2.7	7.5	1.8	-2.7	1.0	1.2	0.6
HDL Cholesterol	0.5	0.8	1.2	1.1	-0.9	-0.7	0.0	-1.1
LDL Cholesterol	0.9	1.4	3.8	0.2	1.7	0.2	-0.2	-1.9
Lupus	0.6	0.8	2.0	-1.4	-1.1	0.8	0.5	0.2
Neuroticism (2016)	0.3	0.4	1.0	-0.2	-1.0	-0.7	-0.4	-0.4
Primary Biliary Cirrhosis	0.7	1.1	3.7	-0.3	1.9	-0.3	0.7	-1.0
Rheumatoid Arthritis	1.3	1.7	3.7	-0.7	-1.3	-1.5	-0.8	1.9
Schizophrenia (2014)	0.1	0.3	0.4	-0.4	-0.6	-0.7	-0.6	0.2
Triglycerides	0.8	1.3	3.0	1.4	0.4	1.7	0.5	1.0
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.6	1.6	0.5	1.0	1.0	-0.6
Ulcerative Colitis	0.7	1.0	3.0	-0.5	1.7	0.7	0.4	1.0
Blood Eosinophil Count	0.3	2.5	10.5	1.3	-3.2	0.2	-0.5	-0.3
Blood Platelet Count	1.5	17.0	71.4	-2.8	8.4	1.0	-1.3	-1.8
Blood Red Count	1.0	9.9	32.2	-2.0	0.8	-5.7	-3.5	0.7
Blood White Count	0.7	5.5	12.5	-1.7	0.3	-3.2	-3.5	-1.4
Heel T-Score	1.5	12.1	54.6	1.6	7.4	1.1	1.5	0.4
BMI	0.5	3.0	7.2	-2.2	-0.3	-0.8	-1.5	-2.7
Height	1.2	22.4	68.1	2.6	-8.2	-4.2	-3.9	2.1
Waist Hip Ratio (WHR)	1.3	5.9	21.4	1.8	4.6	-0.7	2.0	-0.3
Systolic Blood Pressure	2.9	14.5	29.4	4.7	3.0	3.2	5.4	1.1
Smoking Status	0.3	0.7	2.1	-0.4	0.2	-1.5	-0.9	0.4
Allergy or Eczema	1.3	3.3	12.7	0.8	1.2	1.2	3.6	-0.7
Cardiovascular Disease	0.9	2.9	6.1	1.8	2.5	2.0	0.2	1.2
Hypothyroidism (self reported)	0.4	0.8	1.9	1.0	-0.5	1.4	0.4	-0.8
Respiratory disease	0.3	0.7	2.1	0.3	0.6	1.4	0.0	-0.9
Type 2 Diabetes (T2D) (2018)	1.1	2.1	2.9	1.7	1.4	1.6	-0.9	1.5
Lung FEV1/FVC ratio	1.6	8.0	15.8	-0.9	3.3	-0.2	3.5	-4.0
Lung FVC	2.2	11.3	17.3	-4.2	4.1	-3.9	-1.9	-1.9
Neuroticism	0.2	0.4	1.3	0.2	-0.6	-0.1	-1.2	-0.4
Chronotype (morning person)	0.3	0.7	1.8	0.3	1.4	0.3	-0.2	1.3
Hair Pigment	0.0	1.3	3.3	0.2	-0.4	-1.7	-1.8	0.3
Tanning	0.1	1.1	3.9	-2.0	-0.4	-0.8	0.3	0.9
Hand grip strength (left)	0.4	1.0	1.9	1.2	-1.2	0.4	-1.4	-0.4
Number of treatments/medications taken	0.3	0.5	1.1	0.8	-0.2	0.6	0.6	1.0
Average weekly spirits intake	2.2	2.7	6.0	-0.8	-1.0	2.5	2.4	-0.0
Sensitivity / hurt feelings	0.5	0.9	2.4	0.9	0.1	0.7	-0.7	-1.5
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.9	0.3	-0.7	1.7	-0.0	0.8
Hearing difficulty/problems: Yes	1.0	1.5	5.1	2.3	-0.7	1.2	0.3	0.6
Relative age of first facial hair	0.8	1.7	4.3	2.1	-0.2	1.3	0.3	-1.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.5	1.2	-0.4	0.5	-0.1	0.7
Ever used hormone-replacement therapy (HRT)	1.1	1.4	5.8	-0.4	-2.4	-0.9	-0.2	-0.4
Ever had hysterectomy (womb removed)	0.8	0.9	3.2	-1.8	-0.2	-0.4	-1.0	-0.5
Systolic blood pressure, automated reading	1.7	5.1	14.5	2.3	1.3	2.0	3.8	0.2
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	5.0	1.7	1.1	2.2	0.7	-0.5
Angina	0.1	0.2	0.5	0.5	0.1	-0.7	0.1	0.1
Medication for hormone replacement therapy	0.2	0.3	0.8	-0.3	-0.9	-0.3	-0.1	-0.6
Vitamin and mineral supplements	0.1	0.2	0.5	-0.1	-0.4	-0.4	-0.7	0.4
Supplements: Zinc	1.2	1.3	4.8	-0.5	2.2	0.7	-0.8	0.6
Medication: Co-codamol	1.1	1.2	2.0	-1.1	-1.0	-1.4	-1.2	0.7
Medication: Metformin	0.8	1.2	3.2	1.8	1.2	0.6	-0.8	0.5
Diabetes (father)	0.5	0.6	2.4	0.7	-0.1	1.5	-0.1	0.1
Diabetes (mother)	0.9	1.1	3.1	1.8	-0.7	1.1	-0.9	0.3
Severe depression (siblings)	0.2	0.2	0.5	0.7	0.3	0.2	0.5	0.4
Pack years adult smoking proportion	0.6	0.8	2.0	1.4	-0.4	1.0	1.0	0.0
Impedance of leg (right)	1.2	5.7	19.2	1.0	4.4	0.5	2.5	1.4
Leg fat-free mass (left)	1.3	7.1	15.4	-0.9	-3.9	-2.0	-3.8	-0.8
Trunk fat percentage	0.3	1.0	2.4	-1.6	1.1	-0.5	-0.8	-0.8
Hand grip strength (right)	0.3	1.0	2.1	0.9	-0.5	-1.2	-1.5	-0.1
Townsend deprivation index at recruitment	0.8	1.2	4.2	2.0	-1.1	-0.4	0.5	0.4
Current tobacco smoking	0.1	0.2	0.4	-0.4	0.5	-0.6	-0.2	0.1
Average weekly fortified wine intake	1.0	1.2	4.2	-1.0	-2.0	-0.5	-0.2	0.8
Maternal smoking around birth	0.9	1.4	3.7	-0.7	1.9	-1.2	-1.0	0.1
Fed-up feelings	0.5	1.0	2.1	1.5	-1.2	0.9	0.3	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.2	-0.4	0.5	-0.7	0.6
Relative age voice broke	0.8	1.3	4.7	0.7	2.2	0.9	0.2	-0.6
Taking other prescription medications	0.6	0.9	2.9	0.7	0.4	1.7	0.6	0.7
Age when periods started (menarche)	0.4	1.0	2.7	-1.6	0.2	-1.3	-0.4	-0.4
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.6	-1.9	-1.7	-0.3	-0.1	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.6	0.8	1.9	0.7	-0.3	1.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.5	-0.1	0.2	-0.6	0.8	1.6
Qualifications: CSEs or equivalent	1.4	1.9	3.5	0.9	1.8	1.9	0.2	-1.4
Serious illness, injury or assault to yourself	0.8	1.0	2.3	0.6	1.5	-0.1	-0.2	1.5
High blood pressure	0.6	1.7	5.2	0.9	0.6	1.6	0.2	2.3
Hayfever, allergic rhinitis or eczema	1.6	3.5	11.3	0.5	1.5	1.7	3.4	-1.0
Multivitamins +/- minerals	0.2	0.3	1.3	-0.3	0.3	-1.1	-0.3	0.1
Stomach or abdominal pain in last month	1.1	1.4	4.1	2.0	-0.2	-0.3	-1.4	0.7
Supplements: Glucosamine	1.1	1.4	3.5	-1.0	0.1	-1.2	-1.9	-1.0
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.6	1.7	-1.1	1.9	1.3	0.8
Medication: Atenolol	1.4	1.8	4.2	0.9	-2.0	0.6	1.4	1.2
Medication: Levothyroxine sodium	0.3	0.5	1.1	0.5	-0.8	0.8	-0.1	-1.0
Sitting height	0.4	2.7	5.8	-0.0	-2.4	-1.0	-2.3	1.1
Chronic bronchitis/emphysema (father)	0.6	0.7	2.2	-0.5	-0.1	-1.0	-1.5	0.3
High blood pressure (mother)	1.0	1.4	5.8	0.3	2.4	-0.7	0.0	0.6
Body mass index (BMI)	0.5	2.0	3.4	-1.9	-0.2	-0.1	-1.8	-1.8
Impedance of leg (left)	1.1	5.4	16.6	1.1	4.1	0.6	2.3	1.9
Leg predicted mass (left)	1.4	7.2	15.1	-0.8	-3.9	-2.1	-3.9	-0.8
Trunk fat mass	0.4	1.8	4.2	-1.6	-0.3	-1.1	-2.1	-0.9
Waist circumference	0.4	1.6	3.8	-0.7	0.6	-1.1	-1.9	-1.5
Number of incorrect matches in round	0.5	0.8	2.8	-0.1	0.5	1.7	-0.7	0.7
Past tobacco smoking	0.0	0.1	0.2	0.4	-0.2	-0.3	0.2	0.4
Alcohol usually taken with meals	0.4	0.7	1.2	-0.7	-1.1	-1.1	-0.5	0.6
Nervous feelings	0.7	1.3	3.0	-0.6	1.1	-1.4	-1.7	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	5.6	-0.6	-0.2	-0.4	-2.4	1.2
Hearing difficulty/problems with background noise	0.5	0.7	2.8	1.7	-0.4	-0.0	-0.8	0.4
Hair/balding pattern: Pattern 2	0.9	1.1	3.5	-1.9	1.3	-0.3	-0.4	-0.6
Had menopause	1.8	2.3	9.6	-0.9	-3.1	-0.1	0.9	0.2
Had other major operations	1.5	1.8	7.6	-0.1	-2.8	1.0	0.2	0.7
Forced vital capacity (FVC)	1.9	7.2	17.1	-2.2	0.9	-4.1	-3.2	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	5.6	0.2	2.4	1.0	0.3	1.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.1	1.5	-1.0	-0.0	-0.3	0.7
Qualifications: None of the above	0.5	1.1	2.9	-1.3	0.1	-1.0	0.3	-1.7
Financial difficulties in last 2 years	1.2	1.6	3.7	-0.3	1.9	-0.1	-1.0	1.7
Mouth/teeth dental problems	1.2	1.9	5.1	1.9	-2.2	-0.7	0.5	-0.3
Heart attack	0.6	0.8	2.6	0.2	0.9	-0.5	0.3	1.6
Allergy	0.8	1.8	3.1	-0.1	-1.7	-1.1	-1.8	1.2
Pain all over the body in last month	1.0	1.0	3.3	0.3	1.1	1.8	0.5	0.7
Diabetes (self-reported)	1.1	1.7	2.8	1.7	1.2	1.6	-0.0	1.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.0	-1.2	1.4	0.4	0.9	-0.8
Medication: Ramipril	1.1	1.4	2.8	1.7	-0.5	0.6	1.2	1.5
Medication: Simvastatin	0.4	0.6	1.2	0.9	1.1	0.5	-0.3	0.8
Fluid intelligence score	0.1	0.2	0.5	0.4	-0.5	0.4	0.4	0.7
Illnesses of siblings	1.1	1.5	6.9	-2.6	0.3	-0.3	0.0	0.7
Neuroticism score	0.4	0.8	4.1	-0.1	-0.4	-0.1	-2.0	-0.2
Weight	0.9	4.6	11.7	-1.6	-2.1	-1.7	-3.4	-1.1
Impedance of arm (right)	0.8	3.6	9.5	2.2	1.5	0.8	3.1	0.9
Arm fat percentage (right)	0.3	1.0	2.3	-1.5	0.3	-0.2	-0.8	-1.5
Trunk fat-free mass	2.2	12.6	26.4	-0.8	-4.8	-3.4	-5.1	-0.8
Hip circumference	0.9	3.9	10.3	-1.3	-2.1	-1.0	-3.2	-1.6
Time employed in main current job	0.8	1.0	2.0	-1.0	-1.0	0.7	-0.7	1.4
Alcohol intake versus 10 years previously	0.7	1.1	3.7	1.0	1.9	-0.1	0.6	0.4
Father’s age at death	1.0	1.4	3.9	-2.0	0.7	-1.2	-1.0	0.3
Worrier / anxious feelings	0.3	0.6	2.1	-0.4	1.5	-0.4	-0.5	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.2	1.1	-0.9	0.4	-0.7	1.8
Falls in the last year	0.4	0.5	1.7	0.8	0.3	0.1	1.3	-0.3
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	-1.0	-0.1	-1.1	-0.8	-0.7
Number of live births	0.8	1.1	2.6	-1.4	1.6	0.1	-0.9	-0.3
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	8.8	-1.6	2.3	-3.0	-1.1	-2.1
Pulse rate	1.6	2.6	9.0	-1.4	0.2	-1.5	-3.0	-0.1
Happiness	0.1	0.1	0.2	-0.3	-0.5	-0.3	-0.5	0.1
Noisy workplace	0.3	0.3	0.9	0.9	-0.3	0.3	0.5	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.4	-0.4	-0.5	-1.2	0.2	1.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	0.2	-0.9	0.6	-0.2	0.5
Mouth/teeth dental problems: Dentures	1.1	1.8	4.2	-1.8	2.1	0.6	-0.9	0.5
Asthma	0.2	0.4	1.5	-0.1	1.2	-0.2	-0.8	-0.0
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.0	8.0	1.4	-2.8	1.3	1.6	0.8
Medication: Cholesterol lowering	1.0	1.6	4.0	1.4	2.0	1.1	0.1	0.9
Depression (self-reported)	0.5	0.6	2.0	-0.1	0.8	0.0	-1.4	0.4
Medication: Lansoprazole	1.3	1.5	2.8	-1.0	0.7	-1.2	-1.7	1.4
Prospective memory result	0.8	1.0	3.0	0.5	-1.7	-0.0	1.2	0.7
Lung cancer (father)	0.5	0.5	1.0	-1.0	-0.8	-1.0	-0.3	-0.2
Illnesses of mother	0.5	0.6	1.4	-0.5	-0.7	0.8	-0.6	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	6.2	-2.0	2.0	-1.7	-0.6	-2.5
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	-0.8	-0.2	-0.1	-1.0	0.8
Impedance of arm (left)	0.6	2.9	5.9	1.1	2.4	0.0	2.4	1.3
Arm fat mass (right)	0.5	1.9	3.6	-1.6	-0.7	-0.8	-1.9	-1.5
Trunk predicted mass	2.3	12.9	27.4	-0.8	-4.8	-3.5	-5.2	-0.8
Standing height	1.1	10.7	19.7	0.5	-4.4	-3.9	-4.2	0.8
Length of working week for main job	0.5	0.6	1.7	0.7	-0.1	-0.8	0.2	1.3
Exposure to tobacco smoke at home	0.5	0.5	2.0	0.2	0.8	-0.3	0.2	1.4
Breastfed as a baby	0.6	0.8	2.4	0.1	-1.5	-0.8	-0.3	-0.9
Tense / ‘highly strung’	0.2	0.3	0.8	-0.3	-0.9	-0.4	-0.4	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.2	0.8	-0.5	-0.9	-2.1	1.7
Hair/balding pattern: Pattern 4	0.6	1.5	5.2	2.3	-0.1	-0.0	-0.2	1.5
Birth weight of first child	1.1	2.1	5.9	0.1	-2.4	-2.0	-0.5	0.4
Peak expiratory flow (PEF)	0.8	1.8	6.9	0.4	0.5	-2.6	-0.6	-1.1
Pulse wave reflection index	1.1	1.4	2.6	1.2	-1.4	0.7	0.5	1.6
Ever highly irritable/argumentative for 2 days	2.5	3.0	4.7	1.6	-0.6	2.2	1.6	2.2
Loud music exposure frequency	0.8	0.8	2.1	-1.5	0.5	-0.4	0.7	1.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	-1.1	0.3	-0.8	-0.3	0.5
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	1.8	0.6	1.2	1.1	1.4	-0.9
Blood clot in the leg (DVT)	0.6	0.8	2.0	-1.4	0.6	-0.7	-1.1	-0.3
Medication: Paracetamol	1.4	2.2	7.1	1.3	-2.7	0.1	0.6	1.4
Headache pain in last month	0.8	1.3	2.7	0.0	-1.0	-1.6	-1.6	-0.6
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	6.1	-1.0	-2.5	-1.0	-0.5	-0.2
Glaucoma (self-reported)	1.3	1.6	4.0	0.2	2.0	0.3	-1.1	-1.6
Gout (self-reported)	0.2	0.3	0.8	-0.6	0.9	0.1	-0.6	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.9	1.0	-0.3	1.4	0.3	-1.4
Medication: Amlodipine	2.0	2.8	6.1	1.8	1.8	2.5	0.6	1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	1.1	0.3	0.5	0.4	0.2
Birth weight	2.7	5.8	15.4	-1.1	-3.9	-3.0	-1.9	0.2
Chronic bronchitis/emphysema (mother)	1.9	2.2	3.3	-0.6	1.4	-1.6	-1.6	1.8
High blood pressure (siblings)	1.3	1.9	8.6	2.9	-0.1	0.8	0.6	0.0
Forced vital capacity (FVC), Best measure	1.2	4.5	7.5	-2.5	0.9	-2.7	-2.3	-1.8
Body fat percentage	0.4	1.6	3.6	-1.9	1.4	-0.3	-1.2	-1.0
Leg fat percentage (right)	0.5	1.9	3.1	-1.8	1.8	0.2	-1.1	-1.4
Arm fat-free mass (right)	1.9	9.9	24.7	-1.5	-3.4	-3.3	-5.0	-0.4
Exposure to tobacco smoke outside home	1.0	1.3	3.3	-1.5	1.8	-0.8	-0.3	0.2
Comparative body size at age 10	0.7	1.9	3.0	-1.3	-0.6	1.6	1.7	-1.4
Number of full brothers	0.9	1.1	1.8	-1.3	1.2	-1.1	-1.0	-0.5
Worry too long after embarrassment	0.7	1.2	2.7	1.1	-1.7	1.1	-0.8	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.4	0.5	-0.7	-0.2	0.4
Wheeze or whistling in the chest in last year	0.6	1.0	3.0	0.2	0.9	-0.2	-1.7	1.1
Number of children fathered	0.7	0.8	1.4	-0.6	-0.7	1.2	0.8	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	2.1	-0.7	-0.9	-0.8	-1.4	1.4
Age at first live birth	0.4	0.7	1.8	1.0	0.1	0.2	0.8	1.3
Pulse wave peak to peak time	0.3	0.4	0.7	0.8	0.1	-0.2	0.8	-0.8
Health satisfaction	0.8	1.0	3.0	1.7	-0.3	0.3	-1.3	-0.4
Shortness of breath walking on level ground	0.8	1.0	1.9	0.4	-1.4	0.7	-1.3	-0.7
Qualifications: College or University degree	0.9	2.8	7.2	1.9	-1.7	-0.1	0.8	2.7
Eye problems/disorders: None of the above	0.4	0.5	1.2	-0.8	-1.1	-0.2	-0.4	0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.7	0.3	0.3	-0.8	0.7	0.6
Emphysema/chronic bronchitis	0.7	0.8	1.6	-0.9	-1.3	0.5	-0.5	-1.0
Medication for pain relief, constipation, heartburn	1.0	1.7	3.4	-1.9	1.7	-0.2	-0.3	-1.5
Neck or shoulder pain in last month	0.7	1.1	3.2	0.8	-0.8	-0.7	0.4	1.8
Medication: Blood pressure	0.5	0.8	3.3	0.2	1.8	0.8	0.6	0.2
Angina (self-reported)	0.1	0.1	0.5	0.2	0.3	-0.7	0.1	0.1
Migraine (self-reported)	1.0	1.2	2.9	-1.2	-0.8	-0.7	-1.7	-0.8
Medication: Ibuprofen	2.3	2.7	9.2	0.8	-3.0	1.2	1.5	0.5
Medication: Allopurinol	0.6	0.8	1.5	-1.1	1.2	-0.3	-1.0	0.6
Medication: Omeprazole	0.5	0.6	1.0	0.4	1.0	-0.7	-1.0	0.6
Medication: Seretide 50 evohaler	0.7	0.9	3.0	0.3	1.7	-0.5	0.9	-0.2
Mean time to correctly identify matches	0.4	0.8	2.9	-1.7	-0.3	-0.7	-0.1	-0.7
Heart disease (mother)	0.8	1.0	2.0	0.8	-1.3	0.8	1.4	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	5.5	-0.5	-0.6	0.0	2.4	0.2
Whole body fat mass	0.4	1.7	4.4	-1.6	-0.3	-0.7	-2.1	-1.0
Leg fat mass (right)	0.5	1.7	4.5	-1.5	0.1	-0.4	-2.1	-1.3
Arm predicted mass (right)	1.9	9.5	24.2	-1.6	-3.3	-3.1	-4.9	-0.5
Pulse rate, automated reading	0.8	2.7	6.0	-2.5	1.1	-1.9	-1.7	-0.3
Alcohol intake frequency.	0.4	1.0	2.4	1.6	1.4	0.0	-0.2	0.7
Comparative height size at age 10	1.1	5.8	16.6	-0.6	-4.1	-2.9	-1.7	1.0
Number of full sisters	1.8	2.2	6.1	1.3	0.3	2.5	1.6	0.5
Suffer from ‘nerves’	0.4	0.6	1.3	-0.6	-0.1	-0.5	-1.1	1.0
Overall health rating	0.5	1.1	1.9	1.2	1.0	0.9	-1.4	0.0
Chest pain or discomfort	0.6	0.9	3.8	-0.3	1.9	0.0	0.0	0.6
Had major operations	0.9	1.0	2.5	-0.2	-0.6	-1.6	-1.5	-0.0
Age at last live birth	0.6	0.9	2.2	1.5	0.2	0.0	0.4	1.5
Family relationship satisfaction	0.1	0.1	0.2	-0.1	0.4	-0.5	-0.3	0.1
Leg pain on walking	1.1	1.4	4.2	-0.6	-2.0	0.6	0.1	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.5	0.1	1.3	1.6	-0.2	0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	0.5	-0.1	-0.6	0.1	-0.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.9	0.3	-0.8	-0.9	-0.5	-2.0
Medication: Aspirin	0.8	1.1	3.9	0.6	-0.0	-0.1	-1.2	2.0
Supplements: Vitamin C	0.7	0.8	2.1	0.3	-1.5	0.5	1.1	-0.6
Knee pain experienced in last month	0.5	0.7	2.1	0.2	-1.0	0.4	-0.6	1.5
Hypertension (Self-reported)	0.4	1.1	3.6	-0.1	1.0	1.0	-0.2	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.1	4.8	-2.0	2.0	-2.2	-1.0	-1.3
Illnesses of father: Heart disease	0.6	0.9	2.4	1.5	-0.9	-0.0	0.7	0.8
Illnesses of siblings: Diabetes	0.6	0.7	1.6	1.1	0.2	1.3	-0.7	-0.3
Smoking status: Previous	0.2	0.2	0.5	-0.7	-0.5	0.7	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.2	1.5	0.0	0.1	-0.2	0.6
Whole body fat-free mass	1.9	10.9	23.9	-0.9	-4.6	-2.9	-4.9	-0.6
Leg fat-free mass (right)	1.5	8.1	19.3	-0.7	-4.4	-2.0	-4.0	-0.5
Arm fat percentage (left)	0.4	1.4	3.6	-1.9	0.7	-0.4	-1.2	-1.2
Average weekly red wine intake	1.7	2.5	3.8	1.7	-1.6	2.0	1.7	0.0
Handedness (chirality/laterality): Left-handed	0.6	0.8	3.0	-1.7	-0.4	-0.8	0.2	-0.1
Mood swings	0.3	0.5	1.3	0.1	0.9	-0.3	-1.1	-0.4
Loneliness, isolation	1.5	2.1	8.5	1.0	-1.0	2.9	0.2	0.3
Long-standing illness, disability or infirmity	0.7	1.0	2.1	1.5	-0.7	1.2	0.5	0.9
Ever had bowel cancer screening	0.4	0.5	1.1	0.0	0.8	-0.6	-0.6	-1.1
Diabetes diagnosed by doctor	1.2	2.0	3.8	1.9	1.3	1.9	-0.2	0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.4	1.2	1.1	0.2	-1.2	-1.2
Friendships satisfaction	1.7	2.1	6.8	2.6	-0.6	1.4	-0.3	-1.2
Qualifications: nursing, teaching	0.3	0.4	1.0	0.6	-1.0	-0.4	-0.5	0.4
Commuting to job workplace: Walk	0.9	1.0	2.6	-1.6	0.4	-1.0	-0.4	1.1
Eye problems/disorders: Cataract	1.0	1.2	4.1	1.0	-2.0	0.9	-0.2	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.5	-0.5	-0.2	1.6	-0.3	0.8
Medication for cholesterol	0.5	0.7	3.0	-0.4	0.3	0.4	-0.2	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.9	-0.9	-0.4	0.8	0.8	-1.7
Back pain experienced in last month	2.1	3.0	6.1	-1.7	0.4	-2.3	-2.5	-0.9
Mineral and other dietary supplements	0.4	0.5	1.1	0.0	0.7	0.3	1.1	0.8
Breast cancer (self-reported)	0.5	0.6	1.5	-0.0	-1.0	0.1	0.5	1.2
Asthma (self-reported)	0.2	0.4	1.1	-0.1	1.1	0.0	-0.8	-0.0
Osteoporosis (self-reported)	0.7	0.9	1.8	-0.1	-1.3	0.7	0.6	-1.4
Osteoarthritis (self-reported)	1.5	1.9	9.2	-0.1	-3.0	0.5	0.5	0.0
Medication: Aspirin	1.4	1.9	6.2	0.5	-0.4	-0.2	-1.6	2.5
Medication: Gliclazide	0.9	1.0	3.0	1.1	1.7	-0.7	-0.3	0.1
Illnesses of father: None of the above (group 1)	0.8	0.9	2.5	-1.6	0.4	-0.9	-0.4	-1.0
Smoking status: Current	0.2	0.4	0.9	-0.5	0.8	-0.9	-0.3	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	11.1	-2.3	1.6	-0.8	0.0	-3.3
Whole body water mass	1.9	11.1	24.4	-1.0	-4.5	-3.1	-4.9	-0.5
Leg predicted mass (right)	1.5	8.1	19.2	-0.7	-4.4	-2.0	-4.0	-0.7
Arm fat mass (left)	0.5	1.9	3.6	-1.7	-0.7	-1.0	-1.9	-1.3
Number of self-reported non-cancer illnesses	0.2	0.3	1.2	-0.4	0.4	1.1	0.3	0.1
Average weekly champagne plus white wine intake	0.4	0.6	1.5	0.4	-1.1	1.2	0.3	-0.1
Miserableness	1.0	1.7	4.4	0.8	-2.1	-0.8	-1.2	1.2
Guilty feelings	0.7	1.0	2.4	0.0	-0.2	0.5	-1.5	1.5
Wears glasses or contact lenses	0.1	0.1	0.4	-0.6	-0.1	-0.2	0.4	0.3
Ever taken oral contraceptive pill	0.3	0.4	1.2	-0.0	-0.1	0.1	0.8	1.1
Hearing aid user	3.4	3.8	5.1	2.3	-2.0	2.2	2.1	0.8
Mother’s age at death	1.3	1.6	4.1	-0.1	-2.0	1.8	0.1	-0.8
Financial situation satisfaction	0.4	0.5	1.1	0.3	1.0	-0.6	-0.7	0.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.0	1.4	1.1	-0.3	0.8	0.2
Commuting to job workplace: Public transport	0.8	0.9	3.5	-0.1	0.4	1.9	0.1	1.0
Eye problems/disorders: Glaucoma	2.3	2.8	8.9	-0.4	3.0	0.2	-1.8	-1.3
Medication: Blood pressure	0.4	0.8	3.8	-0.5	0.1	-0.0	0.3	1.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.7	-0.5	-1.1	-0.2	-1.2	1.3
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	0.7	-0.9	0.1	0.4	0.1
High cholesterol (Self-reported)	1.0	1.8	6.9	0.7	2.6	1.3	0.2	0.1
Medication: Bendroflumethiazide	0.3	0.5	1.4	-0.4	-0.9	0.3	1.2	0.3
Medication: Paracetamol	0.8	1.2	5.0	1.0	-2.2	0.1	0.1	0.5
Medication: Lisinopril	1.1	1.5	5.6	-0.2	2.4	-0.2	-0.5	1.2
Medication: Atorvastatin	0.6	0.7	1.9	-0.9	0.4	1.4	0.6	-0.3
Illnesses of father: High blood pressure	0.1	0.1	0.4	-0.1	0.2	0.0	0.4	-0.6
Alcohol drinker status: Never	0.5	0.6	1.6	-0.5	0.9	-1.3	-0.6	-0.2
Ever smoked	0.2	0.4	1.1	-0.5	0.7	-0.0	-0.5	-1.0
Basal metabolic rate	1.6	9.0	21.3	-1.1	-3.8	-2.7	-4.6	-0.8
Leg fat percentage (left)	0.4	1.4	2.7	-1.6	1.3	0.3	-1.2	-1.2
Arm fat-free mass (left)	1.8	9.3	20.7	-1.1	-3.8	-3.0	-4.5	-0.9
Number of operations (self-reported)	1.2	1.8	4.5	-1.2	-2.1	-1.6	-0.8	0.5
Average weekly beer plus cider intake	0.5	0.8	1.4	1.2	0.8	-0.7	0.2	-1.1
Irritability	0.9	1.6	5.0	1.0	0.5	1.2	-0.6	-2.2
Risk taking	0.0	0.1	0.1	-0.3	0.3	-0.0	-0.2	-0.3
Ever had prostate specific antigen (PSA) test	1.5	1.8	5.2	0.1	-1.6	-1.0	0.0	2.3
Fractured/broken bones in last 5 years	0.9	1.2	2.2	0.9	-1.2	0.2	1.3	1.5
Age started oral contraceptive pill	1.2	1.5	3.0	-1.1	-1.7	-1.5	0.5	0.8
Diastolic blood pressure, automated reading	1.1	3.5	10.3	2.6	0.0	0.7	3.2	0.4
Ever depressed for a whole week	1.0	1.3	3.0	1.7	-1.0	-0.9	-0.5	1.1
Unable to work because of sickness or disability	0.3	0.4	0.8	-0.1	-0.7	0.6	-0.9	0.3
Commuting to job workplace: Cycle	0.4	0.5	1.8	0.3	-0.6	-0.2	-0.4	-1.3
Myopia	0.2	0.3	0.5	-0.5	0.7	-0.7	0.6	0.1
Vascular/heart problems diagnosed by doctor	0.6	1.6	5.4	-0.6	-0.9	-1.2	0.1	-2.3
Cholesterol lowering medication	0.5	0.7	1.6	0.1	1.0	-0.2	-0.9	1.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.7	0.4	0.8	-0.5	-1.2	1.3
Pain experienced in last month	0.5	0.9	1.9	0.4	0.6	0.7	1.4	-1.2
Supplements: Calcium	1.4	1.6	4.4	1.5	-0.5	2.1	-0.0	-0.9
Basal cell carcinoma (self-reported)	1.2	1.4	3.2	0.8	1.1	1.4	1.8	0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.2	0.4	1.0	-0.4	0.5	1.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.4	-1.6	0.7	-0.9	-1.1	0.2
Heart disease (siblings)	0.2	0.2	0.6	0.8	-0.4	-0.1	0.4	-0.6
Alcohol drinker status: Previous	1.4	1.6	2.8	1.7	0.9	1.4	0.8	1.2
Pack years of smoking	0.8	1.2	1.9	1.4	-1.0	1.1	1.4	-0.2
Impedance of whole body	0.9	4.7	11.7	1.2	3.4	0.3	2.7	1.8
Leg fat mass (left)	0.4	1.6	4.4	-1.5	-0.2	-0.3	-2.1	-1.2
Arm predicted mass (left)	1.7	8.7	19.3	-1.4	-3.8	-2.8	-4.4	-0.5