Hub : Genes

TNS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1430 0.0400 6.8e-05 0.097 0.034 0.071 0.085 0.096 8.0e-12 4.6e-05 5.1e-09 1.6e-10 1.1e-11
2 METSIM Adipose 0.0452 0.0219 7.8e-03 -0.002 0.010 -0.001 0.009 -0.001 7.4e-01 1.1e-02 4.0e-01 1.5e-02 5.8e-01
3 NTR Blood 0.0345 0.0147 5.2e-03 0.003 0.004 0.001 0.005 0.003 3.3e-02 1.1e-02 1.6e-01 5.4e-03 2.2e-02
4 YFS Blood 0.1519 0.0253 0.0e+00 0.109 0.105 0.114 0.122 0.111 1.3e-33 1.6e-32 2.2e-35 8.3e-38 2.4e-34
5 TCGA Stomach Adenocarcinoma 0.1220 0.0510 6.4e-03 0.014 0.012 0.008 NA 0.001 3.0e-02 4.2e-02 8.0e-02 NA 2.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.8 1.3 2.8 1.0 0.3 1.5 0.4 -1.7
Bipolar Disorder or Schizophrenia 0.1 0.2 0.4 0.4 0.5 0.6 -0.0 -0.4
Depressed Affect (Nagel 2018) 0.3 0.5 1.7 1.3 -1.0 0.2 0.2 -0.2
Depression (Nagel 2018) 0.3 0.4 0.7 0.7 -0.7 0.7 -0.2 0.8
Intelligence (Savage-Jansen 2018) 0.2 0.8 2.3 0.4 1.5 -0.2 0.7 0.9
Neuroticism (Nagel 2018) 0.2 0.4 1.7 1.3 -0.5 -0.0 -0.3 -0.3
Schizophrenia (2018) 0.1 0.3 0.9 -0.3 0.5 -0.4 -0.3 0.9
Schizophrenia vs Biploar Disorder 0.4 0.5 1.3 -1.2 -0.8 0.5 0.1 0.7
Worry (Nagel 2018) 0.2 0.4 1.1 -0.5 0.3 -1.0 -0.7 -0.0
Alzheimer’s Disease (in mother) 0.1 0.2 0.5 -0.2 -0.7 0.2 0.1 -0.5
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.6 0.0 -0.6 -0.2 -0.6
Alzheimer’s Disease (including proxy) 0.3 0.5 1.3 -0.8 -0.7 0.0 0.3 -1.1
Crohns Disease (2017) 1.4 3.0 10.1 -0.1 1.2 1.6 1.0 -3.2
Irritable Bowel Disease (IBD) 0.8 1.9 3.8 -0.0 1.5 1.9 0.6 -1.8
Ulcerative Colitis (UC) 0.4 0.8 2.1 0.2 1.4 1.3 -0.0 0.4
Major Depression (MDD) 1.0 1.2 4.1 -0.2 -2.0 1.1 -0.2 -0.7
Reaction Time 0.2 0.5 2.2 -1.5 0.1 0.3 0.1 -0.1
Verbal and Numeric Reasoning (VNR) 0.4 1.0 3.8 0.9 -0.5 -0.6 1.9 0.3
Breast Cancer 0.4 0.9 2.3 1.5 -0.6 1.0 -0.9 0.1
Ovarian Cancer 0.3 0.4 0.8 -0.4 -0.9 0.7 -0.5 0.4
Prostate Cancer 0.1 0.2 0.5 0.3 0.7 -0.3 -0.5 -0.1
Age at First Birth 0.1 0.1 0.3 -0.1 0.5 -0.1 0.5 -0.1
Bipolar Disorder (2011) 0.6 0.6 1.2 1.1 1.1 0.7 0.5 0.0
Body Mass Index (BMI) (2010) 2.0 2.8 3.8 -1.4 1.4 1.6 2.0 -1.9
Coronary Artery Disease (CAD) 2.8 3.4 8.2 2.9 -2.3 -0.1 0.9 1.6
Crohns Disease (2012) 0.9 1.4 5.7 -0.2 0.3 0.1 1.1 -2.4
Mean Putamen Volume 0.4 0.5 0.9 1.0 0.2 0.9 0.8 -0.0
Fasting Glucose 0.1 0.1 0.4 0.3 -0.1 -0.2 -0.6 -0.3
HbA1C 2.4 2.7 7.5 1.8 -2.7 1.0 1.2 0.6
HDL Cholesterol 0.5 0.8 1.2 1.1 -0.9 -0.7 0.0 -1.1
LDL Cholesterol 0.9 1.4 3.8 0.2 1.7 0.2 -0.2 -1.9
Lupus 0.6 0.8 2.0 -1.4 -1.1 0.8 0.5 0.2
Neuroticism (2016) 0.3 0.4 1.0 -0.2 -1.0 -0.7 -0.4 -0.4
Primary Biliary Cirrhosis 0.7 1.1 3.7 -0.3 1.9 -0.3 0.7 -1.0
Rheumatoid Arthritis 1.3 1.7 3.7 -0.7 -1.3 -1.5 -0.8 1.9
Schizophrenia (2014) 0.1 0.3 0.4 -0.4 -0.6 -0.7 -0.6 0.2
Triglycerides 0.8 1.3 3.0 1.4 0.4 1.7 0.5 1.0
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.6 1.6 0.5 1.0 1.0 -0.6
Ulcerative Colitis 0.7 1.0 3.0 -0.5 1.7 0.7 0.4 1.0
Blood Eosinophil Count 0.3 2.5 10.5 1.3 -3.2 0.2 -0.5 -0.3
Blood Platelet Count 1.5 17.0 71.4 -2.8 8.4 1.0 -1.3 -1.8
Blood Red Count 1.0 9.9 32.2 -2.0 0.8 -5.7 -3.5 0.7
Blood White Count 0.7 5.5 12.5 -1.7 0.3 -3.2 -3.5 -1.4
Heel T-Score 1.5 12.1 54.6 1.6 7.4 1.1 1.5 0.4
BMI 0.5 3.0 7.2 -2.2 -0.3 -0.8 -1.5 -2.7
Height 1.2 22.4 68.1 2.6 -8.2 -4.2 -3.9 2.1
Waist Hip Ratio (WHR) 1.3 5.9 21.4 1.8 4.6 -0.7 2.0 -0.3
Systolic Blood Pressure 2.9 14.5 29.4 4.7 3.0 3.2 5.4 1.1
Smoking Status 0.3 0.7 2.1 -0.4 0.2 -1.5 -0.9 0.4
Allergy or Eczema 1.3 3.3 12.7 0.8 1.2 1.2 3.6 -0.7
Cardiovascular Disease 0.9 2.9 6.1 1.8 2.5 2.0 0.2 1.2
Hypothyroidism (self reported) 0.4 0.8 1.9 1.0 -0.5 1.4 0.4 -0.8
Respiratory disease 0.3 0.7 2.1 0.3 0.6 1.4 0.0 -0.9
Type 2 Diabetes (T2D) (2018) 1.1 2.1 2.9 1.7 1.4 1.6 -0.9 1.5
Lung FEV1/FVC ratio 1.6 8.0 15.8 -0.9 3.3 -0.2 3.5 -4.0
Lung FVC 2.2 11.3 17.3 -4.2 4.1 -3.9 -1.9 -1.9
Neuroticism 0.2 0.4 1.3 0.2 -0.6 -0.1 -1.2 -0.4
Chronotype (morning person) 0.3 0.7 1.8 0.3 1.4 0.3 -0.2 1.3
Hair Pigment 0.0 1.3 3.3 0.2 -0.4 -1.7 -1.8 0.3
Tanning 0.1 1.1 3.9 -2.0 -0.4 -0.8 0.3 0.9
Hand grip strength (left) 0.4 1.0 1.9 1.2 -1.2 0.4 -1.4 -0.4
Number of treatments/medications taken 0.3 0.5 1.1 0.8 -0.2 0.6 0.6 1.0
Average weekly spirits intake 2.2 2.7 6.0 -0.8 -1.0 2.5 2.4 -0.0
Sensitivity / hurt feelings 0.5 0.9 2.4 0.9 0.1 0.7 -0.7 -1.5
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.9 0.3 -0.7 1.7 -0.0 0.8
Hearing difficulty/problems: Yes 1.0 1.5 5.1 2.3 -0.7 1.2 0.3 0.6
Relative age of first facial hair 0.8 1.7 4.3 2.1 -0.2 1.3 0.3 -1.6
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.5 1.2 -0.4 0.5 -0.1 0.7
Ever used hormone-replacement therapy (HRT) 1.1 1.4 5.8 -0.4 -2.4 -0.9 -0.2 -0.4
Ever had hysterectomy (womb removed) 0.8 0.9 3.2 -1.8 -0.2 -0.4 -1.0 -0.5
Systolic blood pressure, automated reading 1.7 5.1 14.5 2.3 1.3 2.0 3.8 0.2
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 5.0 1.7 1.1 2.2 0.7 -0.5
Angina 0.1 0.2 0.5 0.5 0.1 -0.7 0.1 0.1
Medication for hormone replacement therapy 0.2 0.3 0.8 -0.3 -0.9 -0.3 -0.1 -0.6
Vitamin and mineral supplements 0.1 0.2 0.5 -0.1 -0.4 -0.4 -0.7 0.4
Supplements: Zinc 1.2 1.3 4.8 -0.5 2.2 0.7 -0.8 0.6
Medication: Co-codamol 1.1 1.2 2.0 -1.1 -1.0 -1.4 -1.2 0.7
Medication: Metformin 0.8 1.2 3.2 1.8 1.2 0.6 -0.8 0.5
Diabetes (father) 0.5 0.6 2.4 0.7 -0.1 1.5 -0.1 0.1
Diabetes (mother) 0.9 1.1 3.1 1.8 -0.7 1.1 -0.9 0.3
Severe depression (siblings) 0.2 0.2 0.5 0.7 0.3 0.2 0.5 0.4
Pack years adult smoking proportion 0.6 0.8 2.0 1.4 -0.4 1.0 1.0 0.0
Impedance of leg (right) 1.2 5.7 19.2 1.0 4.4 0.5 2.5 1.4
Leg fat-free mass (left) 1.3 7.1 15.4 -0.9 -3.9 -2.0 -3.8 -0.8
Trunk fat percentage 0.3 1.0 2.4 -1.6 1.1 -0.5 -0.8 -0.8
Hand grip strength (right) 0.3 1.0 2.1 0.9 -0.5 -1.2 -1.5 -0.1
Townsend deprivation index at recruitment 0.8 1.2 4.2 2.0 -1.1 -0.4 0.5 0.4
Current tobacco smoking 0.1 0.2 0.4 -0.4 0.5 -0.6 -0.2 0.1
Average weekly fortified wine intake 1.0 1.2 4.2 -1.0 -2.0 -0.5 -0.2 0.8
Maternal smoking around birth 0.9 1.4 3.7 -0.7 1.9 -1.2 -1.0 0.1
Fed-up feelings 0.5 1.0 2.1 1.5 -1.2 0.9 0.3 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.5 -0.2 -0.4 0.5 -0.7 0.6
Relative age voice broke 0.8 1.3 4.7 0.7 2.2 0.9 0.2 -0.6
Taking other prescription medications 0.6 0.9 2.9 0.7 0.4 1.7 0.6 0.7
Age when periods started (menarche) 0.4 1.0 2.7 -1.6 0.2 -1.3 -0.4 -0.4
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 3.6 -1.9 -1.7 -0.3 -0.1 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 3.6 0.8 1.9 0.7 -0.3 1.3
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 2.5 -0.1 0.2 -0.6 0.8 1.6
Qualifications: CSEs or equivalent 1.4 1.9 3.5 0.9 1.8 1.9 0.2 -1.4
Serious illness, injury or assault to yourself 0.8 1.0 2.3 0.6 1.5 -0.1 -0.2 1.5
High blood pressure 0.6 1.7 5.2 0.9 0.6 1.6 0.2 2.3
Hayfever, allergic rhinitis or eczema 1.6 3.5 11.3 0.5 1.5 1.7 3.4 -1.0
Multivitamins +/- minerals 0.2 0.3 1.3 -0.3 0.3 -1.1 -0.3 0.1
Stomach or abdominal pain in last month 1.1 1.4 4.1 2.0 -0.2 -0.3 -1.4 0.7
Supplements: Glucosamine 1.1 1.4 3.5 -1.0 0.1 -1.2 -1.9 -1.0
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 3.6 1.7 -1.1 1.9 1.3 0.8
Medication: Atenolol 1.4 1.8 4.2 0.9 -2.0 0.6 1.4 1.2
Medication: Levothyroxine sodium 0.3 0.5 1.1 0.5 -0.8 0.8 -0.1 -1.0
Sitting height 0.4 2.7 5.8 -0.0 -2.4 -1.0 -2.3 1.1
Chronic bronchitis/emphysema (father) 0.6 0.7 2.2 -0.5 -0.1 -1.0 -1.5 0.3
High blood pressure (mother) 1.0 1.4 5.8 0.3 2.4 -0.7 0.0 0.6
Body mass index (BMI) 0.5 2.0 3.4 -1.9 -0.2 -0.1 -1.8 -1.8
Impedance of leg (left) 1.1 5.4 16.6 1.1 4.1 0.6 2.3 1.9
Leg predicted mass (left) 1.4 7.2 15.1 -0.8 -3.9 -2.1 -3.9 -0.8
Trunk fat mass 0.4 1.8 4.2 -1.6 -0.3 -1.1 -2.1 -0.9
Waist circumference 0.4 1.6 3.8 -0.7 0.6 -1.1 -1.9 -1.5
Number of incorrect matches in round 0.5 0.8 2.8 -0.1 0.5 1.7 -0.7 0.7
Past tobacco smoking 0.0 0.1 0.2 0.4 -0.2 -0.3 0.2 0.4
Alcohol usually taken with meals 0.4 0.7 1.2 -0.7 -1.1 -1.1 -0.5 0.6
Nervous feelings 0.7 1.3 3.0 -0.6 1.1 -1.4 -1.7 0.4
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 5.6 -0.6 -0.2 -0.4 -2.4 1.2
Hearing difficulty/problems with background noise 0.5 0.7 2.8 1.7 -0.4 -0.0 -0.8 0.4
Hair/balding pattern: Pattern 2 0.9 1.1 3.5 -1.9 1.3 -0.3 -0.4 -0.6
Had menopause 1.8 2.3 9.6 -0.9 -3.1 -0.1 0.9 0.2
Had other major operations 1.5 1.8 7.6 -0.1 -2.8 1.0 0.2 0.7
Forced vital capacity (FVC) 1.9 7.2 17.1 -2.2 0.9 -4.1 -3.2 -1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 5.6 0.2 2.4 1.0 0.3 1.6
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.1 1.5 -1.0 -0.0 -0.3 0.7
Qualifications: None of the above 0.5 1.1 2.9 -1.3 0.1 -1.0 0.3 -1.7
Financial difficulties in last 2 years 1.2 1.6 3.7 -0.3 1.9 -0.1 -1.0 1.7
Mouth/teeth dental problems 1.2 1.9 5.1 1.9 -2.2 -0.7 0.5 -0.3
Heart attack 0.6 0.8 2.6 0.2 0.9 -0.5 0.3 1.6
Allergy 0.8 1.8 3.1 -0.1 -1.7 -1.1 -1.8 1.2
Pain all over the body in last month 1.0 1.0 3.3 0.3 1.1 1.8 0.5 0.7
Diabetes (self-reported) 1.1 1.7 2.8 1.7 1.2 1.6 -0.0 1.3
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 2.0 -1.2 1.4 0.4 0.9 -0.8
Medication: Ramipril 1.1 1.4 2.8 1.7 -0.5 0.6 1.2 1.5
Medication: Simvastatin 0.4 0.6 1.2 0.9 1.1 0.5 -0.3 0.8
Fluid intelligence score 0.1 0.2 0.5 0.4 -0.5 0.4 0.4 0.7
Illnesses of siblings 1.1 1.5 6.9 -2.6 0.3 -0.3 0.0 0.7
Neuroticism score 0.4 0.8 4.1 -0.1 -0.4 -0.1 -2.0 -0.2
Weight 0.9 4.6 11.7 -1.6 -2.1 -1.7 -3.4 -1.1
Impedance of arm (right) 0.8 3.6 9.5 2.2 1.5 0.8 3.1 0.9
Arm fat percentage (right) 0.3 1.0 2.3 -1.5 0.3 -0.2 -0.8 -1.5
Trunk fat-free mass 2.2 12.6 26.4 -0.8 -4.8 -3.4 -5.1 -0.8
Hip circumference 0.9 3.9 10.3 -1.3 -2.1 -1.0 -3.2 -1.6
Time employed in main current job 0.8 1.0 2.0 -1.0 -1.0 0.7 -0.7 1.4
Alcohol intake versus 10 years previously 0.7 1.1 3.7 1.0 1.9 -0.1 0.6 0.4
Father’s age at death 1.0 1.4 3.9 -2.0 0.7 -1.2 -1.0 0.3
Worrier / anxious feelings 0.3 0.6 2.1 -0.4 1.5 -0.4 -0.5 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 3.2 1.1 -0.9 0.4 -0.7 1.8
Falls in the last year 0.4 0.5 1.7 0.8 0.3 0.1 1.3 -0.3
Hair/balding pattern: Pattern 3 0.5 0.7 1.3 -1.0 -0.1 -1.1 -0.8 -0.7
Number of live births 0.8 1.1 2.6 -1.4 1.6 0.1 -0.9 -0.3
Forced expiratory volume in 1-second (FEV1) 1.3 4.5 8.8 -1.6 2.3 -3.0 -1.1 -2.1
Pulse rate 1.6 2.6 9.0 -1.4 0.2 -1.5 -3.0 -0.1
Happiness 0.1 0.1 0.2 -0.3 -0.5 -0.3 -0.5 0.1
Noisy workplace 0.3 0.3 0.9 0.9 -0.3 0.3 0.5 -0.6
Qualifications: A levels/AS levels or equivalent 0.5 1.1 3.4 -0.4 -0.5 -1.2 0.2 1.9
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.8 0.2 -0.9 0.6 -0.2 0.5
Mouth/teeth dental problems: Dentures 1.1 1.8 4.2 -1.8 2.1 0.6 -0.9 0.5
Asthma 0.2 0.4 1.5 -0.1 1.2 -0.2 -0.8 -0.0
Medication: Ibuprofen (e.g. Nurofen) 2.4 3.0 8.0 1.4 -2.8 1.3 1.6 0.8
Medication: Cholesterol lowering 1.0 1.6 4.0 1.4 2.0 1.1 0.1 0.9
Depression (self-reported) 0.5 0.6 2.0 -0.1 0.8 0.0 -1.4 0.4
Medication: Lansoprazole 1.3 1.5 2.8 -1.0 0.7 -1.2 -1.7 1.4
Prospective memory result 0.8 1.0 3.0 0.5 -1.7 -0.0 1.2 0.7
Lung cancer (father) 0.5 0.5 1.0 -1.0 -0.8 -1.0 -0.3 -0.2
Illnesses of mother 0.5 0.6 1.4 -0.5 -0.7 0.8 -0.6 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.5 6.2 -2.0 2.0 -1.7 -0.6 -2.5
Pulse wave Arterial Stiffness index 0.4 0.5 1.0 -0.8 -0.2 -0.1 -1.0 0.8
Impedance of arm (left) 0.6 2.9 5.9 1.1 2.4 0.0 2.4 1.3
Arm fat mass (right) 0.5 1.9 3.6 -1.6 -0.7 -0.8 -1.9 -1.5
Trunk predicted mass 2.3 12.9 27.4 -0.8 -4.8 -3.5 -5.2 -0.8
Standing height 1.1 10.7 19.7 0.5 -4.4 -3.9 -4.2 0.8
Length of working week for main job 0.5 0.6 1.7 0.7 -0.1 -0.8 0.2 1.3
Exposure to tobacco smoke at home 0.5 0.5 2.0 0.2 0.8 -0.3 0.2 1.4
Breastfed as a baby 0.6 0.8 2.4 0.1 -1.5 -0.8 -0.3 -0.9
Tense / ‘highly strung’ 0.2 0.3 0.8 -0.3 -0.9 -0.4 -0.4 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 4.2 0.8 -0.5 -0.9 -2.1 1.7
Hair/balding pattern: Pattern 4 0.6 1.5 5.2 2.3 -0.1 -0.0 -0.2 1.5
Birth weight of first child 1.1 2.1 5.9 0.1 -2.4 -2.0 -0.5 0.4
Peak expiratory flow (PEF) 0.8 1.8 6.9 0.4 0.5 -2.6 -0.6 -1.1
Pulse wave reflection index 1.1 1.4 2.6 1.2 -1.4 0.7 0.5 1.6
Ever highly irritable/argumentative for 2 days 2.5 3.0 4.7 1.6 -0.6 2.2 1.6 2.2
Loud music exposure frequency 0.8 0.8 2.1 -1.5 0.5 -0.4 0.7 1.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.2 -1.1 0.3 -0.8 -0.3 0.5
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 1.8 0.6 1.2 1.1 1.4 -0.9
Blood clot in the leg (DVT) 0.6 0.8 2.0 -1.4 0.6 -0.7 -1.1 -0.3
Medication: Paracetamol 1.4 2.2 7.1 1.3 -2.7 0.1 0.6 1.4
Headache pain in last month 0.8 1.3 2.7 0.0 -1.0 -1.6 -1.6 -0.6
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 6.1 -1.0 -2.5 -1.0 -0.5 -0.2
Glaucoma (self-reported) 1.3 1.6 4.0 0.2 2.0 0.3 -1.1 -1.6
Gout (self-reported) 0.2 0.3 0.8 -0.6 0.9 0.1 -0.6 0.1
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.9 1.0 -0.3 1.4 0.3 -1.4
Medication: Amlodipine 2.0 2.8 6.1 1.8 1.8 2.5 0.6 1.1
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.2 1.1 0.3 0.5 0.4 0.2
Birth weight 2.7 5.8 15.4 -1.1 -3.9 -3.0 -1.9 0.2
Chronic bronchitis/emphysema (mother) 1.9 2.2 3.3 -0.6 1.4 -1.6 -1.6 1.8
High blood pressure (siblings) 1.3 1.9 8.6 2.9 -0.1 0.8 0.6 0.0
Forced vital capacity (FVC), Best measure 1.2 4.5 7.5 -2.5 0.9 -2.7 -2.3 -1.8
Body fat percentage 0.4 1.6 3.6 -1.9 1.4 -0.3 -1.2 -1.0
Leg fat percentage (right) 0.5 1.9 3.1 -1.8 1.8 0.2 -1.1 -1.4
Arm fat-free mass (right) 1.9 9.9 24.7 -1.5 -3.4 -3.3 -5.0 -0.4
Exposure to tobacco smoke outside home 1.0 1.3 3.3 -1.5 1.8 -0.8 -0.3 0.2
Comparative body size at age 10 0.7 1.9 3.0 -1.3 -0.6 1.6 1.7 -1.4
Number of full brothers 0.9 1.1 1.8 -1.3 1.2 -1.1 -1.0 -0.5
Worry too long after embarrassment 0.7 1.2 2.7 1.1 -1.7 1.1 -0.8 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.4 0.4 0.5 -0.7 -0.2 0.4
Wheeze or whistling in the chest in last year 0.6 1.0 3.0 0.2 0.9 -0.2 -1.7 1.1
Number of children fathered 0.7 0.8 1.4 -0.6 -0.7 1.2 0.8 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.2 2.1 -0.7 -0.9 -0.8 -1.4 1.4
Age at first live birth 0.4 0.7 1.8 1.0 0.1 0.2 0.8 1.3
Pulse wave peak to peak time 0.3 0.4 0.7 0.8 0.1 -0.2 0.8 -0.8
Health satisfaction 0.8 1.0 3.0 1.7 -0.3 0.3 -1.3 -0.4
Shortness of breath walking on level ground 0.8 1.0 1.9 0.4 -1.4 0.7 -1.3 -0.7
Qualifications: College or University degree 0.9 2.8 7.2 1.9 -1.7 -0.1 0.8 2.7
Eye problems/disorders: None of the above 0.4 0.5 1.2 -0.8 -1.1 -0.2 -0.4 0.5
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.7 0.3 0.3 -0.8 0.7 0.6
Emphysema/chronic bronchitis 0.7 0.8 1.6 -0.9 -1.3 0.5 -0.5 -1.0
Medication for pain relief, constipation, heartburn 1.0 1.7 3.4 -1.9 1.7 -0.2 -0.3 -1.5
Neck or shoulder pain in last month 0.7 1.1 3.2 0.8 -0.8 -0.7 0.4 1.8
Medication: Blood pressure 0.5 0.8 3.3 0.2 1.8 0.8 0.6 0.2
Angina (self-reported) 0.1 0.1 0.5 0.2 0.3 -0.7 0.1 0.1
Migraine (self-reported) 1.0 1.2 2.9 -1.2 -0.8 -0.7 -1.7 -0.8
Medication: Ibuprofen 2.3 2.7 9.2 0.8 -3.0 1.2 1.5 0.5
Medication: Allopurinol 0.6 0.8 1.5 -1.1 1.2 -0.3 -1.0 0.6
Medication: Omeprazole 0.5 0.6 1.0 0.4 1.0 -0.7 -1.0 0.6
Medication: Seretide 50 evohaler 0.7 0.9 3.0 0.3 1.7 -0.5 0.9 -0.2
Mean time to correctly identify matches 0.4 0.8 2.9 -1.7 -0.3 -0.7 -0.1 -0.7
Heart disease (mother) 0.8 1.0 2.0 0.8 -1.3 0.8 1.4 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 5.5 -0.5 -0.6 0.0 2.4 0.2
Whole body fat mass 0.4 1.7 4.4 -1.6 -0.3 -0.7 -2.1 -1.0
Leg fat mass (right) 0.5 1.7 4.5 -1.5 0.1 -0.4 -2.1 -1.3
Arm predicted mass (right) 1.9 9.5 24.2 -1.6 -3.3 -3.1 -4.9 -0.5
Pulse rate, automated reading 0.8 2.7 6.0 -2.5 1.1 -1.9 -1.7 -0.3
Alcohol intake frequency. 0.4 1.0 2.4 1.6 1.4 0.0 -0.2 0.7
Comparative height size at age 10 1.1 5.8 16.6 -0.6 -4.1 -2.9 -1.7 1.0
Number of full sisters 1.8 2.2 6.1 1.3 0.3 2.5 1.6 0.5
Suffer from ‘nerves’ 0.4 0.6 1.3 -0.6 -0.1 -0.5 -1.1 1.0
Overall health rating 0.5 1.1 1.9 1.2 1.0 0.9 -1.4 0.0
Chest pain or discomfort 0.6 0.9 3.8 -0.3 1.9 0.0 0.0 0.6
Had major operations 0.9 1.0 2.5 -0.2 -0.6 -1.6 -1.5 -0.0
Age at last live birth 0.6 0.9 2.2 1.5 0.2 0.0 0.4 1.5
Family relationship satisfaction 0.1 0.1 0.2 -0.1 0.4 -0.5 -0.3 0.1
Leg pain on walking 1.1 1.4 4.2 -0.6 -2.0 0.6 0.1 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.5 0.1 1.3 1.6 -0.2 0.5
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.4 0.5 -0.1 -0.6 0.1 -0.1
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 3.9 0.3 -0.8 -0.9 -0.5 -2.0
Medication: Aspirin 0.8 1.1 3.9 0.6 -0.0 -0.1 -1.2 2.0
Supplements: Vitamin C 0.7 0.8 2.1 0.3 -1.5 0.5 1.1 -0.6
Knee pain experienced in last month 0.5 0.7 2.1 0.2 -1.0 0.4 -0.6 1.5
Hypertension (Self-reported) 0.4 1.1 3.6 -0.1 1.0 1.0 -0.2 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.7 3.1 4.8 -2.0 2.0 -2.2 -1.0 -1.3
Illnesses of father: Heart disease 0.6 0.9 2.4 1.5 -0.9 -0.0 0.7 0.8
Illnesses of siblings: Diabetes 0.6 0.7 1.6 1.1 0.2 1.3 -0.7 -0.3
Smoking status: Previous 0.2 0.2 0.5 -0.7 -0.5 0.7 -0.1 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 2.2 1.5 0.0 0.1 -0.2 0.6
Whole body fat-free mass 1.9 10.9 23.9 -0.9 -4.6 -2.9 -4.9 -0.6
Leg fat-free mass (right) 1.5 8.1 19.3 -0.7 -4.4 -2.0 -4.0 -0.5
Arm fat percentage (left) 0.4 1.4 3.6 -1.9 0.7 -0.4 -1.2 -1.2
Average weekly red wine intake 1.7 2.5 3.8 1.7 -1.6 2.0 1.7 0.0
Handedness (chirality/laterality): Left-handed 0.6 0.8 3.0 -1.7 -0.4 -0.8 0.2 -0.1
Mood swings 0.3 0.5 1.3 0.1 0.9 -0.3 -1.1 -0.4
Loneliness, isolation 1.5 2.1 8.5 1.0 -1.0 2.9 0.2 0.3
Long-standing illness, disability or infirmity 0.7 1.0 2.1 1.5 -0.7 1.2 0.5 0.9
Ever had bowel cancer screening 0.4 0.5 1.1 0.0 0.8 -0.6 -0.6 -1.1
Diabetes diagnosed by doctor 1.2 2.0 3.8 1.9 1.3 1.9 -0.2 0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 1.4 1.2 1.1 0.2 -1.2 -1.2
Friendships satisfaction 1.7 2.1 6.8 2.6 -0.6 1.4 -0.3 -1.2
Qualifications: nursing, teaching 0.3 0.4 1.0 0.6 -1.0 -0.4 -0.5 0.4
Commuting to job workplace: Walk 0.9 1.0 2.6 -1.6 0.4 -1.0 -0.4 1.1
Eye problems/disorders: Cataract 1.0 1.2 4.1 1.0 -2.0 0.9 -0.2 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.5 -0.5 -0.2 1.6 -0.3 0.8
Medication for cholesterol 0.5 0.7 3.0 -0.4 0.3 0.4 -0.2 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 2.9 -0.9 -0.4 0.8 0.8 -1.7
Back pain experienced in last month 2.1 3.0 6.1 -1.7 0.4 -2.3 -2.5 -0.9
Mineral and other dietary supplements 0.4 0.5 1.1 0.0 0.7 0.3 1.1 0.8
Breast cancer (self-reported) 0.5 0.6 1.5 -0.0 -1.0 0.1 0.5 1.2
Asthma (self-reported) 0.2 0.4 1.1 -0.1 1.1 0.0 -0.8 -0.0
Osteoporosis (self-reported) 0.7 0.9 1.8 -0.1 -1.3 0.7 0.6 -1.4
Osteoarthritis (self-reported) 1.5 1.9 9.2 -0.1 -3.0 0.5 0.5 0.0
Medication: Aspirin 1.4 1.9 6.2 0.5 -0.4 -0.2 -1.6 2.5
Medication: Gliclazide 0.9 1.0 3.0 1.1 1.7 -0.7 -0.3 0.1
Illnesses of father: None of the above (group 1) 0.8 0.9 2.5 -1.6 0.4 -0.9 -0.4 -1.0
Smoking status: Current 0.2 0.4 0.9 -0.5 0.8 -0.9 -0.3 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.8 3.8 11.1 -2.3 1.6 -0.8 0.0 -3.3
Whole body water mass 1.9 11.1 24.4 -1.0 -4.5 -3.1 -4.9 -0.5
Leg predicted mass (right) 1.5 8.1 19.2 -0.7 -4.4 -2.0 -4.0 -0.7
Arm fat mass (left) 0.5 1.9 3.6 -1.7 -0.7 -1.0 -1.9 -1.3
Number of self-reported non-cancer illnesses 0.2 0.3 1.2 -0.4 0.4 1.1 0.3 0.1
Average weekly champagne plus white wine intake 0.4 0.6 1.5 0.4 -1.1 1.2 0.3 -0.1
Miserableness 1.0 1.7 4.4 0.8 -2.1 -0.8 -1.2 1.2
Guilty feelings 0.7 1.0 2.4 0.0 -0.2 0.5 -1.5 1.5
Wears glasses or contact lenses 0.1 0.1 0.4 -0.6 -0.1 -0.2 0.4 0.3
Ever taken oral contraceptive pill 0.3 0.4 1.2 -0.0 -0.1 0.1 0.8 1.1
Hearing aid user 3.4 3.8 5.1 2.3 -2.0 2.2 2.1 0.8
Mother’s age at death 1.3 1.6 4.1 -0.1 -2.0 1.8 0.1 -0.8
Financial situation satisfaction 0.4 0.5 1.1 0.3 1.0 -0.6 -0.7 0.6
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.0 1.4 1.1 -0.3 0.8 0.2
Commuting to job workplace: Public transport 0.8 0.9 3.5 -0.1 0.4 1.9 0.1 1.0
Eye problems/disorders: Glaucoma 2.3 2.8 8.9 -0.4 3.0 0.2 -1.8 -1.3
Medication: Blood pressure 0.4 0.8 3.8 -0.5 0.1 -0.0 0.3 1.9
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.7 -0.5 -1.1 -0.2 -1.2 1.3
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.9 0.7 -0.9 0.1 0.4 0.1
High cholesterol (Self-reported) 1.0 1.8 6.9 0.7 2.6 1.3 0.2 0.1
Medication: Bendroflumethiazide 0.3 0.5 1.4 -0.4 -0.9 0.3 1.2 0.3
Medication: Paracetamol 0.8 1.2 5.0 1.0 -2.2 0.1 0.1 0.5
Medication: Lisinopril 1.1 1.5 5.6 -0.2 2.4 -0.2 -0.5 1.2
Medication: Atorvastatin 0.6 0.7 1.9 -0.9 0.4 1.4 0.6 -0.3
Illnesses of father: High blood pressure 0.1 0.1 0.4 -0.1 0.2 0.0 0.4 -0.6
Alcohol drinker status: Never 0.5 0.6 1.6 -0.5 0.9 -1.3 -0.6 -0.2
Ever smoked 0.2 0.4 1.1 -0.5 0.7 -0.0 -0.5 -1.0
Basal metabolic rate 1.6 9.0 21.3 -1.1 -3.8 -2.7 -4.6 -0.8
Leg fat percentage (left) 0.4 1.4 2.7 -1.6 1.3 0.3 -1.2 -1.2
Arm fat-free mass (left) 1.8 9.3 20.7 -1.1 -3.8 -3.0 -4.5 -0.9
Number of operations (self-reported) 1.2 1.8 4.5 -1.2 -2.1 -1.6 -0.8 0.5
Average weekly beer plus cider intake 0.5 0.8 1.4 1.2 0.8 -0.7 0.2 -1.1
Irritability 0.9 1.6 5.0 1.0 0.5 1.2 -0.6 -2.2
Risk taking 0.0 0.1 0.1 -0.3 0.3 -0.0 -0.2 -0.3
Ever had prostate specific antigen (PSA) test 1.5 1.8 5.2 0.1 -1.6 -1.0 0.0 2.3
Fractured/broken bones in last 5 years 0.9 1.2 2.2 0.9 -1.2 0.2 1.3 1.5
Age started oral contraceptive pill 1.2 1.5 3.0 -1.1 -1.7 -1.5 0.5 0.8
Diastolic blood pressure, automated reading 1.1 3.5 10.3 2.6 0.0 0.7 3.2 0.4
Ever depressed for a whole week 1.0 1.3 3.0 1.7 -1.0 -0.9 -0.5 1.1
Unable to work because of sickness or disability 0.3 0.4 0.8 -0.1 -0.7 0.6 -0.9 0.3
Commuting to job workplace: Cycle 0.4 0.5 1.8 0.3 -0.6 -0.2 -0.4 -1.3
Myopia 0.2 0.3 0.5 -0.5 0.7 -0.7 0.6 0.1
Vascular/heart problems diagnosed by doctor 0.6 1.6 5.4 -0.6 -0.9 -1.2 0.1 -2.3
Cholesterol lowering medication 0.5 0.7 1.6 0.1 1.0 -0.2 -0.9 1.2
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.7 0.4 0.8 -0.5 -1.2 1.3
Pain experienced in last month 0.5 0.9 1.9 0.4 0.6 0.7 1.4 -1.2
Supplements: Calcium 1.4 1.6 4.4 1.5 -0.5 2.1 -0.0 -0.9
Basal cell carcinoma (self-reported) 1.2 1.4 3.2 0.8 1.1 1.4 1.8 0.3
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.2 0.4 1.0 -0.4 0.5 1.5
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.4 -1.6 0.7 -0.9 -1.1 0.2
Heart disease (siblings) 0.2 0.2 0.6 0.8 -0.4 -0.1 0.4 -0.6
Alcohol drinker status: Previous 1.4 1.6 2.8 1.7 0.9 1.4 0.8 1.2
Pack years of smoking 0.8 1.2 1.9 1.4 -1.0 1.1 1.4 -0.2
Impedance of whole body 0.9 4.7 11.7 1.2 3.4 0.3 2.7 1.8
Leg fat mass (left) 0.4 1.6 4.4 -1.5 -0.2 -0.3 -2.1 -1.2
Arm predicted mass (left) 1.7 8.7 19.3 -1.4 -3.8 -2.8 -4.4 -0.5