Best TWAS P=7.84e-22 · Best GWAS P=3.81e-20 conditioned to 0.169
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | ITGB5 | 0.34 | 0.28 | lasso | 4 | 0.32 | 4.4e-26 | -9.2 | -9.6 | 7.8e-22 | 0.89 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | ITGB5 | 0.30 | 0.17 | lasso | 4 | 0.19 | 2.0e-07 | 6.6 | -9.0 | 1.9e-19 | 0.77 | 0.05 | 0.94 | FALSE |
| 3 | GTEx | Esophagus Mucosa | ITGB5 | 0.23 | 0.16 | enet | 29 | 0.21 | 8.1e-14 | -9.1 | 6.8 | 1.0e-11 | -0.83 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Muscularis | ITGB5 | 0.37 | 0.13 | lasso | 4 | 0.22 | 1.5e-13 | 8.1 | -8.9 | 7.4e-19 | 0.72 | 0.28 | 0.72 | FALSE |
| 5 | GTEx | Nerve Tibial | ITGB5 | 0.10 | 0.01 | lasso | 4 | 0.03 | 2.3e-03 | -9.2 | -8.8 | 8.6e-19 | 0.86 | 0.01 | 0.99 | FALSE |
| 6 | METSIM | Adipose | ITGB5 | 0.05 | 0.04 | lasso | 3 | 0.04 | 2.2e-06 | -9.2 | 9.0 | 1.7e-19 | -0.95 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ITGB5 | 0.05 | 0.00 | blup | 116 | 0.01 | 2.4e-02 | 3.3 | -5.9 | 3.1e-09 | 0.36 | 0.04 | 0.05 | FALSE |