Best TWAS P=4.36e-10 · Best GWAS P=5.23e-10 conditioned to 0.5
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | CCDC58 | 0.12 | 0.08 | lasso | 6 | 0.05 | 5.0e-04 | 5.6 | 5.3 | 8.7e-08 | 0.88 | 0.02 | 0.94 | FALSE |
| 2 | GTEx | Muscle Skeletal | SLC15A2 | 0.11 | 0.05 | enet | 43 | 0.07 | 8.4e-08 | 4.4 | 5.6 | 2.0e-08 | 0.09 | 0.94 | 0.05 | TRUE |
| 3 | GTEx | Nerve Tibial | FAM162A | 0.07 | 0.05 | lasso | 4 | 0.05 | 2.1e-04 | 5.9 | -5.2 | 1.9e-07 | -0.95 | 0.02 | 0.92 | FALSE |
| 4 | GTEx | Nerve Tibial | PARP9 | 0.14 | 0.00 | lasso | 3 | 0.01 | 1.1e-01 | -4.1 | -5.3 | 8.9e-08 | -0.52 | 0.11 | 0.24 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FAM162A | 0.06 | 0.01 | blup | 52 | 0.03 | 3.1e-04 | 6.1 | -6.2 | 4.4e-10 | -0.86 | 0.00 | 0.96 | TRUE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM162A | 0.05 | 0.04 | enet | 4 | 0.05 | 5.6e-06 | 5.6 | 6.1 | 1.0e-09 | 0.90 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FAM162A | 0.15 | 0.10 | lasso | 3 | 0.15 | 4.6e-06 | 6.2 | -5.7 | 1.6e-08 | -0.92 | 0.00 | 0.99 | FALSE |