Best TWAS P=3.83e-18 · Best GWAS P=6.87e-21 conditioned to 0.00916
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | SLCO2A1 | 0.18 | 0.01 | lasso | 5 | -0.01 | 6.8e-01 | -8.8 | -6.5 | 6.4e-11 | -0.57 | 0.06 | 0.38 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | AMOTL2 | 0.09 | 0.06 | enet | 13 | 0.06 | 4.3e-05 | 5.2 | 6.0 | 1.9e-09 | 0.20 | 0.54 | 0.03 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | RPL39P5 | 0.12 | 0.08 | enet | 14 | 0.09 | 2.3e-07 | 5.5 | 6.2 | 5.4e-10 | 0.19 | 0.98 | 0.00 | TRUE |
| 4 | GTEx | Esophagus Mucosa | RYK | 0.08 | 0.08 | enet | 3 | 0.05 | 1.8e-04 | -8.5 | -8.7 | 3.8e-18 | -0.75 | 0.15 | 0.82 | TRUE |
| 5 | GTEx | Nerve Tibial | RYK | 0.15 | 0.13 | lasso | 8 | 0.11 | 5.9e-08 | -7.7 | -8.5 | 1.4e-17 | -0.64 | 0.43 | 0.57 | FALSE |
| 6 | YFS | Blood | CEP63 | 0.21 | 0.21 | enet | 80 | 0.27 | 2.1e-87 | 4.3 | -5.7 | 1.1e-08 | -0.20 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RYK | 0.09 | 0.01 | blup | 63 | 0.01 | 4.8e-02 | -1.9 | -5.6 | 2.1e-08 | -0.55 | 0.02 | 0.29 | FALSE |