Best TWAS P=3.66e-09 · Best GWAS P=3.75e-09 conditioned to 0.123
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | AFAP1 | 0.60 | 0.28 | lasso | 11 | 0.34 | 1.1e-09 | 5.8 | 5.8 | 7.1e-09 | -0.48 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | AFAP1-AS1 | 0.33 | 0.16 | lasso | 7 | 0.16 | 5.9e-05 | 5.8 | 5.9 | 4.7e-09 | -0.54 | 0.01 | 0.96 | FALSE |
| 3 | GTEx | Brain Cerebellum | AFAP1 | 0.47 | 0.19 | lasso | 4 | 0.19 | 2.8e-06 | -5.0 | 5.9 | 3.8e-09 | -0.46 | 0.01 | 0.97 | FALSE |
| 4 | GTEx | Brain Cerebellum | AFAP1-AS1 | 0.47 | 0.05 | lasso | 10 | 0.10 | 7.6e-04 | 4.4 | 5.7 | 1.4e-08 | -0.58 | 0.04 | 0.75 | FALSE |
| 5 | METSIM | Adipose | AFAP1 | 0.05 | 0.03 | enet | 13 | 0.03 | 1.3e-05 | 4.4 | 5.1 | 2.7e-07 | -0.42 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | AFAP1 | 0.08 | 0.00 | lasso | 5 | 0.00 | 4.0e-01 | -4.3 | -5.9 | 3.7e-09 | 0.87 | 0.02 | 0.73 | TRUE |