Hub : Genes

AFAP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.6050 0.1060 2.7e-06 0.285 NA 0.223 NA 0.344 5.2e-08 NA 2.1e-06 NA 1.2e-09
2 GTEx Brain Cerebellum 0.4670 0.1010 2.0e-04 0.194 NA 0.110 NA 0.190 2.1e-06 NA 3.8e-04 NA 2.8e-06
3 GTEx Cells Transformed fibroblasts 0.2630 0.0530 4.1e-07 0.097 NA 0.133 NA 0.120 1.1e-07 NA 3.6e-10 NA 2.8e-09
4 GTEx Colon Transverse 0.2820 0.0890 2.5e-03 0.004 NA 0.035 NA 0.006 2.0e-01 NA 8.8e-03 NA 1.6e-01
5 GTEx Esophagus Mucosa 0.4750 0.0590 1.7e-16 0.403 NA 0.430 NA 0.429 1.0e-28 NA 3.9e-31 NA 4.8e-31
6 GTEx Skin Not Sun Exposed Suprapubic 0.4670 0.0610 1.1e-14 0.460 NA 0.428 NA 0.453 7.0e-28 NA 2.2e-25 NA 2.8e-27
7 GTEx Skin Sun Exposed Lower leg 0.5020 0.0500 0.0e+00 0.453 NA 0.425 NA 0.460 2.4e-41 NA 4.7e-38 NA 4.2e-42
8 GTEx Whole Blood 0.4470 0.0410 0.0e+00 0.480 NA 0.500 NA 0.490 9.4e-50 NA 1.3e-52 NA 3.4e-51
9 METSIM Adipose 0.0505 0.0221 1.1e-02 0.029 0.010 0.032 0.019 0.024 3.4e-05 9.8e-03 1.3e-05 5.8e-04 1.3e-04
10 NTR Blood 0.1291 0.0184 0.0e+00 0.122 0.108 0.124 0.126 0.128 3.2e-37 5.7e-33 8.8e-38 2.2e-38 3.1e-39
11 TCGA Liver Hepatocellular Carcinoma 0.0820 0.0390 8.6e-03 0.001 -0.005 -0.006 NA -0.002 2.7e-01 7.0e-01 9.6e-01 NA 4.0e-01
12 TCGA Pheochromocytoma and Paraganglioma 0.2240 0.0830 7.8e-04 0.126 0.087 0.055 NA 0.054 1.1e-05 2.6e-04 3.1e-03 NA 3.4e-03
13 TCGA Thyroid Carcinoma 0.1510 0.0420 1.9e-09 0.141 0.098 0.139 NA 0.149 1.3e-13 9.7e-10 1.9e-13 NA 2.2e-14

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 0.4 0.6 1.9 1.4 0.2 -1.3 0.1 0.9 0.8 0.8 0.9 0.3 0.3 -1.0 -0.2 -0.1
Bipolar Disorder or Schizophrenia 0.1 0.2 0.9 1.0 -0.1 -0.8 -0.2 0.3 -0.1 -0.0 0.1 -0.1 -0.6 -0.7 -0.7 0.1
Depressed Affect (Nagel 2018) 1.6 3.3 11.4 -2.3 -3.4 1.8 0.7 -1.4 -1.6 -1.6 -1.8 -2.3 -1.1 1.7 1.2 -1.0
Depression (Nagel 2018) 0.5 0.8 1.5 -0.6 -1.1 0.5 1.0 -1.0 -1.1 -1.1 -1.1 -0.5 -0.3 1.2 0.5 0.2
Intelligence (Savage-Jansen 2018) 1.6 4.8 10.9 1.8 1.3 -0.2 0.8 2.8 3.0 3.0 2.9 3.3 2.3 -0.9 -1.9 1.4
Neuroticism (Nagel 2018) 1.9 4.4 8.5 -2.0 -2.9 2.0 -0.8 -2.5 -2.5 -2.5 -2.5 -2.6 -1.9 1.4 1.1 -1.1
Schizophrenia (2018) 0.1 0.3 1.1 0.2 -0.3 0.3 -0.6 -0.4 -0.6 -0.6 -0.6 -0.3 -1.1 -0.1 -0.6 0.2
Schizophrenia vs Biploar Disorder 0.4 0.5 2.7 0.9 1.2 -0.5 1.6 0.5 0.6 0.4 0.3 0.6 0.5 -0.6 0.3 -0.1
Worry (Nagel 2018) 0.9 1.9 3.6 -0.8 -0.9 1.6 -1.2 -1.9 -1.9 -1.9 -1.8 -1.9 -1.3 -0.1 0.2 -0.1
Alzheimer’s Disease (in mother) 0.4 0.5 2.4 0.5 0.9 -1.6 -1.2 0.3 0.3 0.3 0.3 0.5 0.3 -0.6 -0.3 0.5
Alzheimer’s Disease (in father) 1.2 1.3 3.2 -0.9 -0.7 0.7 -1.8 -1.3 -1.3 -1.2 -1.0 -0.8 -1.1 1.6 1.1 0.3
Alzheimer’s Disease (including proxy) 0.3 0.4 2.2 -0.2 0.3 -1.2 -1.5 -0.2 -0.4 -0.5 -0.4 -0.1 -0.4 0.7 0.9 0.3
Crohns Disease (2017) 0.3 0.7 2.0 -0.8 -1.2 1.4 -0.3 0.1 -0.2 -0.2 -0.6 -1.3 -0.5 1.2 0.0 0.9
Irritable Bowel Disease (IBD) 0.6 1.5 4.6 -1.9 -2.1 1.9 -1.2 -0.3 -0.4 -0.4 -0.9 -1.1 -0.6 1.6 0.4 0.4
Ulcerative Colitis (UC) 1.0 2.0 5.4 -2.3 -2.3 1.4 -1.9 -0.8 -0.9 -0.9 -1.3 -0.9 -1.0 1.7 0.6 -0.1
Major Depression (MDD) 1.2 1.4 8.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 2.3 -2.8
Reaction Time 0.5 0.9 4.6 -1.1 0.1 1.3 2.1 -1.0 -0.4 -0.3 -0.4 0.0 0.4 0.5 1.6 -0.2
Verbal and Numeric Reasoning (VNR) 1.3 3.1 6.5 0.9 0.2 1.0 1.8 2.3 2.5 2.4 2.2 2.1 2.1 -0.7 -0.8 1.5
Breast Cancer 0.7 1.8 4.2 1.3 1.3 -0.8 0.4 1.6 1.6 1.6 2.0 2.0 1.5 -0.4 -0.8 0.5
Ovarian Cancer 0.2 0.3 1.4 -0.2 -0.3 -0.8 1.2 0.5 -0.0 0.0 -0.1 -0.3 -0.4 0.1 0.7 -0.9
Prostate Cancer 0.9 1.3 7.6 0.6 0.4 0.5 0.1 0.9 0.9 0.8 0.7 0.0 0.6 -0.5 -2.1 2.8
Age at First Birth 0.8 1.1 6.6 1.0 1.0 -0.6 0.4 0.3 0.6 0.7 0.6 1.6 0.3 -2.6 -1.4 -0.2
Bipolar Disorder (2011) 0.8 0.8 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -1.7 -2.1 1.9
Body Mass Index (BMI) (2010) 0.7 0.9 1.6 -1.2 -0.9 -1.2 -1.0 -1.2 -1.0 -1.1 -0.9 0.2 -0.9 0.4 0.5 -1.1
Coronary Artery Disease (CAD) 2.0 2.3 6.5 -2.0 -1.6 1.5 -0.6 -2.1 -1.5 -1.5 -1.5 -0.9 -1.2 -0.9 0.5 -2.6
Crohns Disease (2012) 1.5 2.3 4.6 1.8 1.3 0.3 0.5 2.2 2.1 2.1 1.7 1.1 1.7 -0.6 -0.9 2.0
Mean Putamen Volume 0.8 0.9 1.8 -0.8 -0.5 0.8 -0.4 -1.3 -1.3 -1.3 -1.4 -0.9 -1.1 -0.2 0.4 -0.9
Fasting Glucose 0.3 0.3 1.7 0.4 0.1 0.6 -1.3 0.9 0.5 0.3 0.2 0.2 -0.1 0.8 0.6 0.2
HbA1C 2.3 2.6 5.0 -1.1 -1.9 0.9 -1.7 -1.8 -1.8 -1.9 -1.7 -2.2 -1.8 -0.1 1.2 -1.6
HDL Cholesterol 0.2 0.4 2.5 0.4 0.4 0.7 1.6 -0.5 -0.6 -0.5 0.0 0.6 -0.1 0.3 0.3 -0.1
LDL Cholesterol 0.3 0.4 1.8 0.4 0.5 -0.6 -1.3 0.5 0.5 0.4 0.7 1.2 0.6 -0.0 -0.3 0.3
Lupus 1.2 1.8 4.0 -0.9 -1.4 1.1 -0.5 -1.6 -2.0 -2.0 -1.9 -1.7 -1.6 0.3 0.3 0.2
Neuroticism (2016) 0.4 0.6 2.5 -1.5 -1.4 0.8 1.6 -0.2 -0.2 -0.2 0.0 -0.2 0.5 0.5 0.3 -0.2
Primary Biliary Cirrhosis 0.6 0.8 1.9 -1.4 -1.3 1.3 -0.3 -0.4 -0.8 -0.9 -0.5 -1.4 -0.8 0.4 -0.8 0.6
Rheumatoid Arthritis 2.6 3.5 5.9 1.5 2.2 0.1 0.4 1.8 2.1 2.1 2.4 2.3 2.3 -2.3 -1.4 1.7
Schizophrenia (2014) 0.2 0.4 1.3 0.5 0.3 -1.1 -0.5 -0.3 -0.4 -0.5 -0.4 0.0 -1.0 -0.9 -0.2 -0.8
Triglycerides 0.4 0.7 2.1 -0.8 -1.2 -0.3 -1.4 -0.6 -0.6 -0.7 -0.9 -0.6 -0.5 0.5 1.5 -0.1
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.5 -0.1 -0.3 -0.3 -0.4 -0.1 0.3 0.2 0.3 0.1 0.7 0.7 0.5 0.0
Ulcerative Colitis 0.9 1.3 3.5 -0.8 -1.3 -0.5 -1.5 1.4 1.4 1.2 0.8 1.2 1.1 -0.0 -1.9 0.2
Blood Eosinophil Count 0.8 5.9 8.9 -2.3 -2.8 1.5 -2.6 -2.3 -2.9 -3.0 -3.0 -2.7 -2.9 1.4 1.7 -1.6
Blood Platelet Count 0.1 1.4 8.5 1.2 0.3 -1.5 -1.5 -0.4 -0.2 -0.3 -0.9 0.5 0.0 1.5 2.9 -0.9
Blood Red Count 0.2 1.6 9.4 1.1 0.5 -1.4 0.5 1.2 0.3 0.4 0.3 0.3 -0.5 -3.1 -2.1 -1.1
Blood White Count 0.2 1.2 8.1 -0.2 -1.1 -1.0 -1.0 0.3 -0.1 -0.1 -0.3 -0.2 -0.2 -2.8 -1.8 0.0
Heel T-Score 0.5 3.7 10.2 -0.5 1.1 2.8 -1.8 -2.6 -1.5 -1.7 -1.6 0.1 -0.9 1.3 2.8 -3.2
BMI 0.9 5.2 8.5 -2.2 -1.9 1.4 -1.9 -2.7 -2.6 -2.7 -2.9 -2.9 -2.5 1.7 0.9 -2.4
Height 2.3 43.7 74.0 8.5 8.6 -6.6 4.3 8.0 7.7 7.5 7.2 8.2 6.4 -3.7 -2.3 1.4
Waist Hip Ratio (WHR) 1.6 7.0 12.4 -2.3 -2.9 3.5 -0.6 -2.8 -3.0 -2.7 -3.0 -3.5 -2.9 1.8 2.5 0.8
Systolic Blood Pressure 3.8 19.1 34.8 5.8 5.9 -2.6 2.2 4.3 4.4 4.5 4.8 5.1 4.3 -5.9 -2.7 1.0
Smoking Status 1.2 2.8 5.0 2.2 2.0 -2.1 0.6 2.1 2.1 2.0 1.6 1.6 1.9 -1.2 -0.2 -0.0
Allergy or Eczema 0.7 2.0 5.3 -0.8 -0.7 0.2 -0.1 -1.1 -1.9 -1.9 -1.6 -2.0 -1.8 0.4 0.4 2.3
Cardiovascular Disease 0.9 2.8 5.0 -1.1 -1.5 1.4 -1.1 -2.1 -1.8 -2.0 -2.2 -2.2 -2.1 1.3 -0.0 -1.5
Hypothyroidism (self reported) 0.7 1.6 3.5 -1.9 -1.7 0.6 -0.5 -1.3 -1.4 -1.5 -1.5 -1.5 -1.4 -0.9 -1.1 0.4
Respiratory disease 2.6 5.8 10.4 -2.7 -2.6 2.6 -1.8 -2.8 -2.6 -2.7 -2.9 -3.2 -2.3 1.7 0.8 -1.5
Type 2 Diabetes (T2D) (2018) 0.3 0.5 2.7 0.2 -0.7 1.1 -1.6 -0.4 -0.3 -0.4 -0.4 -0.4 -0.7 0.0 -0.6 -0.2
Lung FEV1/FVC ratio 4.4 22.2 49.1 6.3 7.0 -3.6 1.5 4.1 4.8 4.6 5.3 6.4 4.8 -5.0 -2.8 -0.2
Lung FVC 0.9 4.3 13.9 -2.2 -0.4 2.6 0.7 -2.3 -1.4 -1.6 -1.2 0.3 -1.4 2.8 3.0 -3.7
Neuroticism 3.8 9.1 14.3 -3.1 -3.7 3.5 -1.7 -3.5 -3.5 -3.4 -3.5 -3.8 -3.0 1.8 1.7 -1.7
Chronotype (morning person) 0.3 0.7 3.3 0.2 0.5 -1.2 -0.3 0.4 0.7 0.6 0.6 0.9 0.8 -1.8 0.2 0.6
Hair Pigment 0.0 0.5 1.1 0.3 0.0 -0.2 1.0 1.0 0.9 1.0 0.7 0.7 1.0 -0.6 -0.1 0.9
Tanning 0.0 0.3 1.7 0.4 0.3 -1.3 0.4 0.1 -0.2 -0.2 -0.2 0.1 -0.3 0.1 0.7 -0.7
Hand grip strength (left) 4.1 10.9 21.3 4.2 4.6 -2.1 2.7 3.5 3.4 3.5 3.8 4.6 3.4 -1.9 -1.2 1.3
Number of treatments/medications taken 1.8 3.2 7.0 -2.1 -2.7 2.4 -1.8 -1.7 -1.5 -1.5 -1.8 -2.6 -1.4 1.0 0.4 0.3
Average weekly spirits intake 8.0 10.0 15.2 -3.5 -3.4 2.3 -2.2 -3.4 -3.3 -3.1 -3.9 -3.4 -3.6 3.6 2.6 -2.1
Sensitivity / hurt feelings 0.9 1.5 2.6 -0.8 -1.2 1.2 -1.5 -1.3 -1.5 -1.6 -1.6 -1.4 -1.4 0.9 0.1 -0.3
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.5 -0.5 -0.9 -0.0 0.8 -0.8 -1.2 -1.2 -1.0 -0.6 -0.4 0.6 0.2 -0.1
Hearing difficulty/problems: Yes 3.4 5.2 15.8 -4.0 -3.2 0.5 -1.8 -2.2 -1.8 -1.9 -2.3 -3.0 -1.6 2.2 1.8 -0.9
Relative age of first facial hair 0.1 0.2 0.8 0.7 0.4 0.9 -0.9 0.1 -0.1 -0.1 0.4 -0.1 0.2 -0.4 -0.5 0.2
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 5.8 -1.7 -2.3 1.5 -2.4 -1.1 -1.1 -1.3 -1.8 -1.4 -1.4 -0.4 -1.2 -0.9
Ever used hormone-replacement therapy (HRT) 1.1 1.3 4.4 -1.8 -2.1 0.0 -1.2 -0.9 -0.8 -0.9 -1.3 -1.7 -0.7 1.0 -0.0 0.5
Ever had hysterectomy (womb removed) 0.3 0.4 1.0 0.9 0.9 -1.0 -0.8 0.1 0.1 0.1 -0.1 0.6 0.3 -0.8 -0.7 0.4
Systolic blood pressure, automated reading 2.2 6.5 14.4 3.3 2.9 -2.0 0.1 2.7 2.4 2.3 2.8 2.7 2.2 -3.8 -2.7 1.3
Eye problems/disorders: Diabetes related eye disease 3.2 3.5 6.6 -2.0 -2.6 1.2 -2.2 -2.0 -1.9 -2.0 -2.1 -1.9 -2.0 1.7 0.3 0.8
Angina 3.3 4.3 11.5 1.4 1.9 -3.4 2.1 1.6 2.1 2.2 2.2 2.5 2.7 -2.2 -0.4 0.1
Medication for hormone replacement therapy 1.3 1.5 2.9 -1.0 -1.2 1.5 -1.5 -1.2 -1.1 -1.3 -1.5 -1.7 -1.6 0.3 0.4 -0.1
Vitamin and mineral supplements 0.6 0.8 1.9 1.2 0.5 -1.0 1.4 1.1 0.9 0.8 1.1 0.9 0.8 -0.5 -0.5 0.8
Supplements: Zinc 0.3 0.3 1.6 -0.0 0.7 0.7 1.3 -0.7 -0.3 -0.3 -0.4 -0.3 -0.4 0.3 0.3 -0.8
Medication: Co-codamol 1.8 2.1 4.5 -1.4 -0.9 1.6 -2.1 -2.0 -1.4 -1.6 -1.4 -1.2 -1.3 1.2 0.1 -1.5
Medication: Metformin 0.9 1.3 4.4 -0.9 -1.6 0.3 -2.1 -1.2 -1.1 -1.1 -1.2 -1.3 -0.9 0.3 -0.3 1.1
Diabetes (father) 1.6 2.0 3.3 -1.0 -0.1 1.6 -0.8 -1.7 -1.4 -1.6 -1.3 -1.3 -1.6 1.6 1.8 -1.6
Diabetes (mother) 1.9 2.4 4.5 -2.1 -1.9 1.7 -0.6 -1.5 -1.4 -1.4 -1.7 -2.1 -1.7 1.6 0.7 -0.4
Severe depression (siblings) 5.7 6.4 10.0 3.2 3.1 -1.7 2.7 2.7 2.4 2.6 2.7 2.7 2.5 -1.9 -1.9 2.4
Pack years adult smoking proportion 0.9 1.3 4.3 -1.2 -1.6 0.9 -2.1 -0.6 -0.6 -0.7 -0.8 -1.1 -1.0 1.5 1.1 -0.7
Impedance of leg (right) 0.5 2.6 6.0 2.4 2.3 -0.3 0.9 1.6 1.6 1.7 1.8 2.3 1.4 -1.4 -0.5 0.6
Leg fat-free mass (left) 0.1 0.5 4.3 0.3 0.8 -2.1 0.2 0.4 0.3 0.0 0.1 0.1 0.0 0.6 -0.1 -0.7
Trunk fat percentage 2.1 8.5 13.8 -3.7 -3.5 1.6 -2.3 -3.0 -2.9 -3.0 -3.2 -3.6 -2.7 3.5 2.1 -1.5
Hand grip strength (right) 3.4 9.3 20.7 3.9 4.6 -1.0 2.9 3.2 3.2 3.2 3.6 4.0 3.2 -1.0 -1.1 1.8
Townsend deprivation index at recruitment 0.9 1.3 8.5 -0.9 0.0 1.3 0.5 -1.0 -0.5 -0.5 -1.1 -1.0 0.0 1.4 2.9 -0.6
Current tobacco smoking 1.6 2.5 5.1 2.0 1.8 -1.0 1.3 1.9 2.1 2.0 1.7 1.8 2.3 -0.3 0.3 -0.1
Average weekly fortified wine intake 0.6 0.7 2.9 -1.0 -1.0 0.4 -0.5 -0.5 -0.7 -0.7 -0.1 -0.3 -0.3 -1.6 -1.7 0.2
Maternal smoking around birth 0.2 0.3 1.3 -0.2 -0.5 -0.3 -0.7 -0.3 -0.2 -0.3 -0.4 -0.0 -0.8 1.1 -0.6 -0.2
Fed-up feelings 3.0 5.4 12.0 -2.3 -3.5 2.6 0.1 -2.2 -2.2 -2.3 -2.5 -3.0 -1.9 2.3 1.7 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 3.4 -1.4 -1.9 0.9 0.1 -1.6 -1.2 -1.3 -1.4 -1.4 -0.5 1.7 1.1 -0.3
Relative age voice broke 0.4 0.7 1.3 0.8 0.8 1.0 -0.8 1.0 0.8 0.7 1.1 0.9 0.7 -0.8 -0.5 0.2
Taking other prescription medications 1.7 2.6 8.4 -1.2 -2.6 1.2 -1.5 -1.4 -1.5 -1.5 -2.1 -2.9 -1.5 0.6 0.0 0.0
Age when periods started (menarche) 0.1 0.3 1.6 0.3 -0.0 0.3 1.3 0.2 -0.2 -0.1 0.0 0.2 0.0 0.1 -1.0 1.2
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 1.2 0.3 1.1 -0.2 -0.1 -0.3 0.2 -0.1 0.1 -0.1 0.3 -0.8 0.3 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 5.3 -0.6 0.4 0.1 -1.2 -1.0 -0.3 -0.4 -0.3 -0.3 -0.5 1.4 2.3 -1.6
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 4.0 -0.7 -0.7 0.6 -2.0 -1.0 -1.1 -1.4 -1.3 -1.8 -1.1 -0.0 0.8 -0.5
Qualifications: CSEs or equivalent 0.9 1.1 1.9 -0.1 -0.7 1.1 0.3 -1.4 -1.3 -1.3 -1.0 -1.3 -1.0 1.4 0.8 -1.1
Serious illness, injury or assault to yourself 0.3 0.3 1.6 -0.5 -1.0 -1.2 0.0 0.6 0.2 0.1 -0.0 -0.1 -0.2 -0.1 -0.8 0.3
High blood pressure 1.2 3.2 5.6 -1.8 -2.1 0.8 -1.4 -2.0 -2.0 -2.1 -2.4 -2.2 -2.3 0.5 1.1 -1.6
Hayfever, allergic rhinitis or eczema 0.5 1.1 4.2 0.0 -0.0 0.8 1.0 -0.6 -1.3 -1.4 -0.9 -1.4 -1.1 0.6 -0.0 2.0
Multivitamins +/- minerals 0.2 0.3 0.9 0.3 0.7 0.2 -1.0 0.2 0.3 0.4 0.4 0.5 0.3 -0.9 -0.6 -0.0
Stomach or abdominal pain in last month 0.5 0.6 1.5 -0.2 -1.1 -0.0 -1.0 -0.7 -0.9 -0.9 -0.9 -1.2 -0.7 0.1 0.5 -0.7
Supplements: Glucosamine 0.4 0.6 3.7 0.5 0.4 -1.1 -1.9 0.8 0.6 0.5 0.5 0.6 0.2 0.1 -0.5 0.2
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 4.9 -0.5 0.3 1.4 1.2 -0.4 -0.5 -0.5 -0.3 -0.5 -0.1 1.2 2.2 -0.5
Medication: Atenolol 0.5 0.6 1.7 0.9 0.4 0.3 0.2 1.0 1.2 1.3 0.8 0.8 1.2 -0.5 0.2 0.1
Medication: Levothyroxine sodium 0.6 1.0 3.2 -1.3 -1.8 0.0 -1.2 -0.8 -0.8 -0.9 -1.1 -0.8 -1.0 -0.4 -1.1 0.1
Sitting height 2.7 19.2 35.8 5.0 5.2 -6.0 2.9 5.4 5.0 4.8 4.8 5.3 4.2 -2.1 -1.5 0.2
Chronic bronchitis/emphysema (father) 0.2 0.2 1.6 0.3 -0.2 0.0 -0.3 0.3 0.4 0.3 0.1 0.3 -0.3 0.5 0.6 -1.3
High blood pressure (mother) 0.2 0.3 0.8 0.9 0.8 -0.9 0.4 -0.2 0.2 0.3 0.4 0.2 0.1 -0.4 0.5 -0.7
Body mass index (BMI) 2.3 9.7 14.9 -3.8 -3.8 1.2 -2.8 -3.5 -3.3 -3.5 -3.6 -3.9 -3.2 3.0 0.8 -2.3
Impedance of leg (left) 0.4 1.9 3.9 2.0 1.9 0.5 0.8 1.2 1.3 1.4 1.5 1.9 1.4 -1.3 0.3 0.8
Leg predicted mass (left) 0.1 0.5 4.2 0.2 0.7 -2.0 0.2 0.5 0.3 0.1 0.1 0.1 0.0 0.7 -0.1 -0.6
Trunk fat mass 1.0 4.2 6.9 -2.6 -2.4 0.5 -1.7 -2.1 -2.0 -2.1 -2.3 -2.6 -2.0 2.5 1.3 -1.5
Waist circumference 1.5 5.3 10.9 -2.6 -3.0 0.9 -1.8 -2.5 -2.5 -2.5 -2.7 -3.3 -2.5 2.0 0.7 -1.2
Number of incorrect matches in round 0.2 0.3 1.7 -0.4 -0.3 -0.7 1.3 0.3 -0.1 -0.0 -0.1 -0.4 -0.4 -0.1 1.1 0.2
Past tobacco smoking 0.9 1.7 4.9 -1.0 -0.7 2.2 -0.4 -1.9 -1.2 -1.3 -1.3 -0.6 -0.8 1.9 1.4 -0.6
Alcohol usually taken with meals 0.9 1.4 4.3 0.4 0.2 -1.1 0.3 1.4 0.8 1.2 1.2 0.4 0.9 -1.9 -1.5 2.1
Nervous feelings 0.2 0.3 0.9 0.3 0.4 0.9 0.7 -0.6 -0.6 -0.6 -0.4 -0.7 -0.2 -0.9 -0.6 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 2.9 -1.3 -1.7 0.9 0.3 -1.4 -1.5 -1.4 -1.2 -1.3 -0.3 0.3 1.1 0.4
Hearing difficulty/problems with background noise 1.1 1.8 5.7 -2.2 -1.7 -1.1 -1.5 -1.0 -1.0 -1.2 -1.3 -2.4 -0.8 0.4 0.8 0.8
Hair/balding pattern: Pattern 2 0.8 1.0 2.3 -0.7 -0.9 1.1 -1.2 -1.1 -1.3 -1.2 -1.0 -0.6 -1.5 0.6 0.6 -0.8
Had menopause 0.8 1.0 2.6 -1.2 -1.4 0.6 -0.2 -0.8 -1.1 -0.9 -1.1 -1.4 -0.8 -0.0 0.2 1.6
Had other major operations 0.4 0.5 1.7 -0.6 -1.3 -1.1 -1.0 -0.2 -0.2 -0.1 -0.5 -0.9 0.2 0.8 -0.2 0.0
Forced vital capacity (FVC) 1.2 4.7 18.3 2.5 4.3 -1.3 2.7 1.5 1.7 1.7 2.1 3.5 1.3 -0.3 0.0 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 5.3 -0.7 0.3 0.3 -1.5 -1.4 -0.8 -0.8 -0.8 -0.3 -0.9 2.0 2.3 -0.8
Ever unenthusiastic/disinterested for a whole week 0.9 1.0 2.6 -0.7 -1.6 1.2 -0.9 -0.3 -0.5 -0.6 -0.7 -1.2 -0.5 1.6 1.5 -0.9
Qualifications: None of the above 1.1 2.4 5.2 -2.2 -2.0 2.3 -0.8 -1.6 -1.3 -1.3 -1.7 -1.4 -1.0 1.2 1.7 -0.2
Financial difficulties in last 2 years 0.5 0.7 1.8 1.3 1.2 0.2 -0.6 0.5 0.8 0.7 0.4 1.0 0.7 -0.1 0.3 -1.4
Mouth/teeth dental problems 3.0 4.6 8.4 2.1 2.3 -2.9 2.6 2.0 2.1 2.1 2.3 2.6 1.8 -2.0 -1.3 -0.6
Heart attack 1.7 2.1 5.8 2.4 1.9 -1.2 0.3 1.5 1.7 1.5 1.4 2.1 1.4 -1.0 -0.3 -0.5
Allergy 0.9 2.1 6.5 0.9 1.3 -1.1 -0.6 1.2 1.7 1.9 1.6 2.5 1.7 -1.3 -0.3 -1.2
Pain all over the body in last month 2.5 2.7 6.9 -2.6 -2.1 1.5 -1.5 -1.2 -1.3 -1.2 -1.5 -1.9 -1.5 2.5 -0.2 -0.1
Diabetes (self-reported) 0.6 1.0 2.9 -0.4 -1.2 -0.1 -1.7 -0.4 -0.7 -0.8 -0.7 -1.4 -0.7 -0.6 -1.4 1.1
Hayfever/allergic rhinitis (self-reported) 2.1 2.7 4.9 2.1 2.2 -0.7 1.7 1.7 1.4 1.2 1.6 1.5 2.0 -2.0 -0.8 1.8
Medication: Ramipril 1.2 1.5 3.1 -1.4 -1.3 0.5 -0.8 -1.7 -1.3 -1.3 -1.4 -1.2 -1.5 0.3 1.2 -1.2
Medication: Simvastatin 0.7 1.1 3.4 0.3 -0.1 -1.9 -1.4 -0.2 -0.3 -0.4 -0.5 -0.5 -0.8 -1.8 -1.4 -1.4
Fluid intelligence score 1.4 3.0 5.2 1.5 1.1 0.9 1.4 2.3 2.3 2.2 2.2 2.0 2.0 -1.1 -1.0 1.6
Illnesses of siblings 1.0 1.4 3.7 0.8 1.3 0.6 1.7 1.6 1.0 1.0 1.4 1.9 0.9 0.5 -1.0 0.9
Neuroticism score 4.0 8.4 12.7 -3.3 -3.5 3.0 -2.0 -3.2 -3.3 -3.3 -3.4 -3.6 -2.7 1.9 2.1 -1.2
Weight 0.2 0.8 2.1 -0.8 -0.6 -1.5 -0.9 -0.6 -0.6 -0.8 -0.9 -0.9 -0.8 1.2 -0.2 -1.1
Impedance of arm (right) 0.3 1.4 3.3 -1.3 -0.7 0.9 -0.1 -1.2 -1.3 -1.1 -0.9 -1.1 -1.3 1.6 1.8 0.7
Arm fat percentage (right) 3.6 14.3 21.9 -4.6 -4.4 1.7 -3.5 -4.1 -4.0 -4.1 -4.3 -4.7 -3.9 4.0 2.0 -2.1
Trunk fat-free mass 1.1 6.3 14.5 3.0 3.5 -3.8 1.2 2.7 2.7 2.4 2.4 2.9 2.2 -1.7 -1.5 -0.1
Hip circumference 0.3 1.2 1.9 -1.2 -1.3 -1.1 -0.9 -1.0 -1.0 -1.1 -1.2 -1.4 -1.0 1.0 -0.8 -0.9
Time employed in main current job 0.1 0.1 0.5 0.4 0.5 0.1 0.6 -0.3 -0.1 -0.2 -0.3 0.1 0.2 -0.0 0.7 -0.2
Alcohol intake versus 10 years previously 0.3 0.4 2.9 -0.2 -0.9 -0.1 -0.0 0.0 0.0 0.0 -0.2 -1.0 -0.2 0.0 -0.7 -1.7
Father’s age at death 0.8 1.1 4.7 0.5 0.4 -0.3 0.7 1.4 0.9 1.1 1.5 1.0 0.9 -0.3 -0.6 2.2
Worrier / anxious feelings 0.7 1.4 3.0 -1.0 -0.7 1.7 -1.7 -1.4 -1.4 -1.4 -1.0 -1.5 -0.7 -0.1 0.1 0.8
Frequency of tiredness / lethargy in last 2 weeks 2.4 3.9 7.2 -1.7 -2.0 2.7 -0.5 -2.1 -2.0 -2.0 -2.1 -2.6 -1.4 2.2 2.1 -1.1
Falls in the last year 1.8 2.5 11.5 -1.6 -1.9 -0.4 -3.4 -1.2 -1.2 -1.6 -1.6 -1.4 -1.5 1.2 -0.1 -0.4
Hair/balding pattern: Pattern 3 2.3 3.5 6.9 2.2 1.4 -1.2 0.1 2.1 2.1 2.2 2.0 1.7 1.8 -2.4 -2.6 0.5
Number of live births 0.9 1.2 2.6 -1.0 -0.9 0.7 -0.6 -1.0 -1.2 -1.4 -1.4 -1.2 -1.3 1.6 0.7 -0.5
Forced expiratory volume in 1-second (FEV1) 1.8 6.0 24.0 3.0 4.9 -1.4 2.1 1.5 2.0 1.9 2.5 4.1 1.7 -0.7 -0.5 -1.5
Pulse rate 0.5 0.8 3.9 0.3 0.6 2.0 -1.8 -0.8 -0.1 -0.2 -0.1 -0.2 0.0 -1.1 -0.9 -0.1
Happiness 0.9 1.1 8.4 1.0 0.3 0.8 2.9 0.5 0.2 0.1 0.5 0.3 0.7 -0.5 -0.2 1.6
Noisy workplace 2.6 3.2 6.6 -2.1 -1.5 2.6 -1.4 -1.9 -1.5 -1.5 -2.2 -2.4 -1.7 1.1 1.7 -1.2
Qualifications: A levels/AS levels or equivalent 0.8 1.8 3.2 1.4 1.5 -0.8 1.8 1.6 1.0 1.1 1.8 1.8 0.9 -1.7 -0.4 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.7 0.6 0.0 -0.8 -0.4 0.0 -0.1 -0.0 0.3 0.8 0.0 0.2 0.3 0.4
Mouth/teeth dental problems: Dentures 1.2 2.1 5.5 -2.1 -2.0 0.8 -2.3 -1.3 -1.2 -1.2 -1.4 -2.0 -0.9 1.0 0.3 0.7
Asthma 2.1 4.1 8.0 -2.7 -2.7 1.6 -1.3 -2.2 -2.0 -2.2 -2.3 -2.8 -2.0 1.4 0.1 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 2.4 -0.8 -0.9 0.7 -1.5 -0.1 -0.0 -0.1 -0.5 -1.2 -0.6 1.0 -0.4 0.5
Medication: Cholesterol lowering 1.4 2.1 7.9 1.3 0.6 -2.4 -0.2 1.2 1.0 1.0 0.9 0.9 0.8 -2.4 -2.8 0.7
Depression (self-reported) 1.2 1.5 6.9 -0.4 -1.0 2.6 -1.9 -1.1 -1.2 -1.1 -1.0 -0.8 -1.1 0.3 -0.8 0.3
Medication: Lansoprazole 3.8 4.3 7.0 -2.6 -1.6 1.1 -1.5 -2.4 -2.2 -2.3 -2.3 -2.6 -2.2 1.6 1.9 -1.8
Prospective memory result 2.2 2.7 5.6 -2.0 -1.8 -0.2 -1.1 -1.3 -1.9 -2.0 -2.0 -2.4 -2.1 1.5 0.7 -0.7
Lung cancer (father) 0.3 0.3 1.1 -0.5 0.7 -0.5 -0.8 -0.1 0.2 0.1 0.1 0.2 -0.6 -0.3 0.8 -1.0
Illnesses of mother 0.3 0.4 1.6 -0.5 -0.7 1.0 -0.8 -0.3 -0.6 -0.6 -0.5 -0.2 -0.5 1.2 -0.2 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 2.2 6.9 24.0 3.2 4.9 -1.3 2.6 2.0 2.4 2.3 2.8 4.3 2.1 0.3 0.2 -1.4
Pulse wave Arterial Stiffness index 1.2 1.3 2.7 1.0 0.5 -0.8 0.3 1.4 1.6 1.4 1.2 0.8 1.3 -1.5 -1.6 0.2
Impedance of arm (left) 0.3 1.5 3.3 -1.2 -0.6 1.8 0.3 -1.0 -1.3 -1.1 -0.9 -1.2 -1.2 1.7 1.8 0.9
Arm fat mass (right) 1.7 7.0 11.1 -3.1 -2.9 0.5 -2.4 -2.9 -2.7 -2.9 -3.0 -3.3 -2.7 3.2 1.2 -1.8
Trunk predicted mass 1.2 6.8 15.0 3.1 3.6 -3.9 1.4 2.9 2.8 2.6 2.5 3.0 2.3 -1.8 -1.6 0.0
Standing height 2.6 25.6 46.4 6.1 6.8 -5.5 3.9 5.9 5.5 5.4 5.5 6.0 4.8 -3.4 -1.9 2.4
Length of working week for main job 1.9 2.1 6.1 -1.5 -0.9 1.3 -1.4 -1.4 -1.1 -1.2 -1.2 -1.7 -1.2 1.3 2.5 -1.4
Exposure to tobacco smoke at home 0.3 0.3 1.1 0.6 -0.1 -0.7 -0.2 0.6 1.1 0.9 0.4 0.4 0.6 -0.3 -0.2 -0.1
Breastfed as a baby 6.2 7.6 11.1 3.3 3.0 -2.8 1.3 3.3 2.9 2.9 2.9 2.4 2.7 -1.7 -2.8 3.2
Tense / ‘highly strung’ 1.1 1.9 5.4 -1.5 -1.2 2.2 -2.3 -1.6 -1.4 -1.4 -1.4 -0.8 -0.6 -0.6 0.4 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 4.3 -1.0 -1.4 2.1 -1.0 -0.2 -0.2 -0.1 -0.5 -1.0 0.1 1.5 1.1 0.8
Hair/balding pattern: Pattern 4 0.1 0.2 0.8 -0.9 -0.8 -0.6 -0.3 0.1 0.0 -0.1 0.0 -0.2 0.4 -0.1 0.6 -0.1
Birth weight of first child 0.2 0.3 2.6 0.1 -0.4 0.1 -0.1 0.2 0.1 0.1 0.1 0.4 -0.1 -0.3 -1.6 0.7
Peak expiratory flow (PEF) 0.3 0.7 3.7 0.9 1.9 -1.2 -0.5 0.7 0.4 0.4 0.7 1.3 0.2 -0.6 -0.3 -0.1
Pulse wave reflection index 1.1 1.3 5.5 0.7 0.2 -2.3 1.9 1.3 1.2 1.2 1.1 0.5 1.0 -0.4 -0.7 0.0
Ever highly irritable/argumentative for 2 days 1.2 1.4 3.1 -0.9 -1.4 1.0 0.6 -0.9 -1.1 -1.0 -1.1 -1.7 -1.1 1.5 1.3 -1.2
Loud music exposure frequency 0.7 0.7 5.0 0.7 -0.3 -2.2 -1.2 0.2 0.1 -0.1 -0.2 -0.2 -0.5 0.9 0.4 -1.1
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 4.1 1.8 1.8 -0.9 0.5 1.2 0.6 0.7 1.2 1.6 0.2 -0.8 -2.0 0.1
Mouth/teeth dental problems: Bleeding gums 2.4 3.1 5.8 -0.8 -1.1 1.9 -1.6 -2.3 -2.4 -2.3 -2.1 -2.0 -2.1 0.7 1.4 -1.0
Blood clot in the leg (DVT) 3.1 4.0 7.3 -2.2 -2.7 1.2 -0.5 -1.8 -1.8 -1.8 -2.3 -2.2 -1.9 2.7 2.1 -1.4
Medication: Paracetamol 0.8 1.3 2.6 -0.9 -1.3 1.6 -1.5 -0.7 -0.7 -0.8 -0.9 -1.4 -0.8 1.3 1.2 -0.8
Headache pain in last month 0.2 0.4 3.3 0.7 0.2 0.1 0.1 0.4 -0.3 -0.3 -0.2 -0.7 -0.0 0.1 0.7 1.8
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 2.8 0.3 0.9 0.7 1.7 0.5 0.4 0.3 0.7 0.4 0.8 0.1 0.2 1.2
Glaucoma (self-reported) 15.3 18.0 36.0 -5.2 -6.0 1.5 -2.9 -4.4 -5.2 -5.2 -5.1 -5.7 -5.2 1.0 0.0 0.2
Gout (self-reported) 0.9 1.3 2.6 -0.8 -1.2 -0.6 -1.3 -1.4 -1.5 -1.6 -1.5 -1.0 -1.1 0.4 0.8 -0.1
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.6 -1.5 -1.6 0.1 -1.6 -0.8 -0.8 -1.0 -1.1 -1.0 -1.1 -1.2 -1.4 0.1
Medication: Amlodipine 1.1 1.5 9.5 -1.1 -1.0 0.1 -3.1 -1.0 -1.0 -1.1 -1.3 -0.7 -1.3 0.4 0.5 -0.9
Medication: Ventolin 100micrograms inhaler 3.4 4.4 11.2 -2.3 -2.2 3.4 -1.8 -2.1 -1.8 -1.9 -2.2 -3.1 -1.8 1.4 0.5 -0.4
Birth weight 0.4 0.8 2.7 1.3 1.1 -0.2 0.4 0.9 0.9 0.8 0.7 1.6 0.5 1.2 0.3 -0.3
Chronic bronchitis/emphysema (mother) 1.7 2.0 3.7 -1.5 -0.8 0.4 -1.8 -1.3 -1.1 -1.4 -1.8 -1.9 -1.8 1.1 1.1 -1.4
High blood pressure (siblings) 0.3 0.5 1.9 0.6 -0.2 -1.4 -1.2 -0.4 -0.2 -0.3 -0.4 -0.9 -0.1 -0.9 0.4 0.1
Forced vital capacity (FVC), Best measure 1.1 4.2 14.7 2.2 3.8 -0.8 2.4 1.3 1.7 1.6 1.8 3.4 1.3 1.1 1.3 -1.4
Body fat percentage 2.3 9.1 14.2 -3.6 -3.7 1.5 -2.8 -3.2 -3.1 -3.2 -3.4 -3.8 -2.9 3.2 1.6 -1.9
Leg fat percentage (right) 1.7 6.1 10.0 -2.7 -3.2 0.7 -3.0 -2.6 -2.6 -2.7 -2.8 -3.0 -2.5 2.0 0.3 -2.0
Arm fat-free mass (right) 0.7 3.7 6.9 2.4 2.6 -2.6 1.6 2.2 2.1 1.8 1.9 2.0 1.9 -1.3 -1.2 0.0
Exposure to tobacco smoke outside home 0.7 0.9 5.1 -1.2 -0.1 0.6 0.0 -1.3 -0.4 -0.5 -1.1 -0.1 -0.7 0.6 1.1 -2.3
Comparative body size at age 10 0.2 0.5 1.2 -0.7 -0.8 -0.8 0.5 -0.3 -0.9 -0.8 0.1 -0.4 -0.6 -0.6 -0.9 1.1
Number of full brothers 0.1 0.1 0.3 0.1 0.0 -0.0 -0.4 0.2 0.4 0.3 0.3 0.4 0.6 -0.6 -0.4 -0.3
Worry too long after embarrassment 2.1 3.5 8.3 -1.9 -2.9 1.8 -2.0 -1.9 -1.7 -1.8 -2.1 -2.3 -1.5 2.0 0.5 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 2.6 -0.7 -1.2 1.0 -1.1 -0.3 -0.3 -0.2 -0.6 -0.7 -0.4 1.6 0.3 0.5
Wheeze or whistling in the chest in last year 2.4 4.3 11.2 -2.7 -2.8 1.0 -1.8 -1.6 -2.0 -2.1 -2.6 -3.3 -2.2 1.3 0.8 -0.6
Number of children fathered 0.6 0.7 3.4 1.1 0.5 -1.8 0.8 1.0 0.6 0.6 0.7 0.7 0.8 -0.7 0.2 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.9 -0.4 -0.8 0.4 0.9 0.1 -0.3 -0.3 -0.2 -0.4 0.0 0.5 0.0 0.3
Age at first live birth 4.6 8.1 12.2 3.1 2.5 -1.4 1.7 2.8 3.1 3.0 3.2 3.5 3.4 -3.2 -3.1 2.1
Pulse wave peak to peak time 0.7 0.9 3.2 -0.7 -0.1 0.5 0.2 -0.9 -1.2 -1.0 -0.9 -0.5 -1.0 1.3 1.8 0.0
Health satisfaction 1.0 1.4 4.4 -1.4 -1.8 0.8 -0.8 -1.2 -1.0 -1.0 -1.2 -2.1 -0.6 0.9 0.1 0.9
Shortness of breath walking on level ground 5.0 6.0 14.9 -2.4 -3.4 1.4 -3.9 -2.5 -2.4 -2.5 -2.6 -3.7 -2.2 -0.0 0.0 -0.5
Qualifications: College or University degree 0.8 2.6 5.5 1.7 2.1 -0.4 0.7 1.8 1.8 1.7 1.7 2.3 1.2 -2.2 -1.0 0.6
Eye problems/disorders: None of the above 8.6 9.9 17.7 3.2 4.2 -3.0 2.6 3.6 3.6 4.0 4.0 3.8 3.1 -1.6 -0.7 1.0
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.9 0.6 0.0 -0.5 -0.6 0.7 0.4 0.4 0.5 -0.0 0.1 -0.2 -0.8 0.9
Emphysema/chronic bronchitis 1.9 2.2 4.7 -1.4 -1.8 -0.6 -0.7 -1.4 -1.6 -1.6 -1.9 -2.2 -1.5 1.2 0.7 -1.6
Medication for pain relief, constipation, heartburn 0.6 1.1 2.7 0.7 1.5 -1.5 1.2 0.9 0.5 0.6 0.9 1.6 0.3 -1.2 -0.3 1.2
Neck or shoulder pain in last month 1.1 1.6 5.6 -0.7 -0.9 0.9 -2.2 -1.0 -0.7 -0.8 -1.2 -1.3 -0.7 2.4 1.4 -0.9
Medication: Blood pressure 0.6 1.0 3.7 -1.3 -1.1 -0.0 -1.9 -0.9 -0.7 -0.6 -0.9 -0.7 -1.0 0.7 1.2 -1.0
Angina (self-reported) 2.8 3.6 9.8 1.2 1.8 -3.1 2.1 1.3 1.9 2.0 2.0 2.3 2.5 -2.0 -0.1 0.1
Migraine (self-reported) 3.0 3.7 10.4 -1.9 -0.8 1.9 -0.2 -2.2 -1.8 -1.8 -1.8 -2.4 -1.2 2.5 3.2 1.3
Medication: Ibuprofen 0.4 0.4 1.9 -0.2 -0.3 0.9 -1.0 0.0 0.1 0.1 0.0 -0.5 -0.0 0.6 -1.1 1.4
Medication: Allopurinol 0.6 0.9 2.6 -0.6 -1.0 -1.0 -1.6 -0.7 -1.2 -1.1 -1.0 -0.7 -0.8 -0.7 -0.6 0.3
Medication: Omeprazole 0.4 0.4 2.0 0.4 -0.3 -0.1 0.2 1.0 0.7 0.8 0.6 -0.5 0.7 0.2 -1.4 -0.1
Medication: Seretide 50 evohaler 0.3 0.3 1.1 -0.6 -0.5 0.2 0.1 -0.6 -0.4 -0.8 -0.7 -0.7 -0.3 0.4 -0.1 -1.0
Mean time to correctly identify matches 0.2 0.3 2.1 -0.8 -0.0 0.7 1.4 -0.8 -0.4 -0.3 -0.2 -0.1 0.2 0.3 0.6 0.1
Heart disease (mother) 3.7 4.5 8.2 1.9 2.0 -2.7 1.2 2.3 2.3 2.5 2.3 2.3 2.0 -2.9 -1.5 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.4 2.9 7.0 1.0 0.4 -2.3 -1.7 2.3 1.7 1.5 1.5 0.9 1.4 -1.8 -2.6 1.9
Whole body fat mass 1.1 4.5 7.8 -2.5 -2.5 0.5 -1.9 -2.2 -2.1 -2.2 -2.4 -2.8 -2.1 2.5 1.2 -1.5
Leg fat mass (right) 0.9 3.7 6.2 -2.1 -2.1 0.1 -2.2 -1.9 -1.9 -2.0 -2.2 -2.5 -2.0 1.9 0.5 -1.9
Arm predicted mass (right) 0.8 4.2 8.2 2.6 2.9 -2.5 1.4 2.3 2.3 2.0 2.0 2.3 2.0 -1.5 -1.4 -0.2
Pulse rate, automated reading 0.1 0.4 2.4 0.2 -0.3 1.5 -0.9 -0.2 0.4 0.3 0.3 -0.3 0.6 -0.8 -0.8 0.3
Alcohol intake frequency. 0.5 1.1 3.1 -0.3 -1.5 0.4 0.4 -1.1 -1.3 -1.3 -1.2 -1.8 -0.9 1.0 -0.2 0.7
Comparative height size at age 10 0.7 4.0 10.6 1.9 2.6 -3.2 2.4 1.8 1.9 1.9 1.8 2.9 1.5 -0.7 0.6 0.1
Number of full sisters 1.3 1.6 4.8 -1.5 -1.0 2.2 -0.7 -1.2 -1.0 -1.0 -1.0 -1.3 -0.7 2.2 0.9 -0.5
Suffer from ‘nerves’ 0.3 0.5 2.1 -0.4 -0.3 0.6 -0.6 -0.8 -0.9 -0.9 -0.8 -1.4 -0.6 -0.5 -0.1 0.4
Overall health rating 0.9 1.8 5.4 -0.9 -1.4 1.2 -0.4 -1.8 -1.4 -1.6 -1.8 -2.3 -1.2 1.1 0.7 -0.4
Chest pain or discomfort 0.1 0.2 1.2 -0.0 -0.3 -0.7 -1.1 0.2 -0.1 -0.2 -0.0 0.1 0.1 -0.7 -0.4 -0.2
Had major operations 1.7 2.0 3.7 -1.1 -1.5 -0.2 -1.9 -1.7 -1.2 -1.4 -1.6 -1.8 -1.2 1.3 1.8 -1.0
Age at last live birth 8.6 12.4 21.8 3.9 3.5 -3.0 1.2 3.6 3.7 3.5 3.8 4.1 4.0 -4.7 -3.7 1.7
Family relationship satisfaction 2.3 2.9 5.9 1.5 1.1 -1.0 1.3 2.2 1.8 1.8 1.7 1.3 1.9 -2.0 -1.3 2.4
Leg pain on walking 2.7 3.4 8.0 2.8 1.9 -2.1 1.1 1.9 2.2 2.1 2.0 1.6 2.0 -1.7 -0.6 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.7 0.3 0.3 -1.3 1.0 0.2 0.4 0.2 0.5 -0.2 0.2 -0.2 -0.8 -1.3
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.1 0.8 1.0 -0.3 0.1 0.8 0.7 0.6 0.5 0.7 0.4 -0.6 -1.0 0.5
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.7 -1.0 -0.2 1.6 0.9 -1.0 -0.8 -0.8 -0.6 -1.6 -1.2 -0.3 -0.2 -1.0
Medication: Aspirin 0.5 0.7 2.8 0.7 -0.2 -1.7 -0.5 0.1 0.5 0.6 0.3 0.8 0.8 -0.9 -0.5 -1.3
Supplements: Vitamin C 2.3 2.7 4.7 -1.4 -1.1 2.2 -0.8 -1.9 -1.7 -1.7 -2.1 -2.1 -1.8 1.6 1.3 -0.5
Knee pain experienced in last month 0.3 0.5 2.6 1.6 1.0 -1.0 -0.7 -0.1 -0.1 -0.3 -0.4 0.2 0.5 -0.9 0.0 0.5
Hypertension (Self-reported) 1.5 4.0 7.2 -2.2 -2.7 0.7 -2.1 -2.1 -2.1 -2.2 -2.6 -2.5 -2.4 0.6 0.9 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 3.4 -1.3 -1.2 1.9 0.1 -0.8 -0.8 -1.0 -0.8 -1.6 -0.6 1.4 -0.1 0.8
Illnesses of father: Heart disease 3.4 4.7 13.9 2.3 2.0 -3.7 1.4 2.3 1.7 1.7 1.8 2.3 1.7 -2.9 -2.2 0.7
Illnesses of siblings: Diabetes 1.1 1.3 2.9 -1.4 -1.4 1.0 -0.8 -1.7 -1.2 -1.3 -1.1 -1.6 -0.8 -0.2 1.0 0.2
Smoking status: Previous 0.4 0.7 2.4 -0.0 -0.3 -1.6 0.0 0.9 0.4 0.5 0.5 -0.3 0.2 -1.6 -1.2 0.8
Forced expiratory volume in 1-second (FEV1), predicted 2.4 5.0 18.3 3.3 4.3 -2.1 1.8 2.0 2.0 2.0 2.2 2.6 1.9 -0.4 0.1 0.7
Whole body fat-free mass 0.5 3.0 9.2 2.0 2.5 -3.0 1.0 1.9 1.8 1.6 1.6 1.8 1.5 -0.8 -0.9 -0.2
Leg fat-free mass (right) 0.1 0.3 3.1 0.2 0.7 -1.8 0.4 0.2 0.1 -0.1 -0.0 -0.1 0.0 0.5 0.2 -0.6
Arm fat percentage (left) 3.8 15.0 24.4 -4.7 -4.5 2.2 -3.2 -4.2 -4.1 -4.2 -4.4 -4.9 -3.9 4.1 2.1 -2.1
Average weekly red wine intake 0.1 0.2 1.0 0.4 0.3 -0.2 -0.3 0.6 0.2 0.3 0.2 0.9 -0.0 0.1 -1.0 -0.1
Handedness (chirality/laterality): Left-handed 0.8 1.0 2.9 -1.7 -1.1 -1.0 -0.0 -1.1 -1.0 -1.2 -1.0 -0.4 -1.0 1.5 0.3 -0.2
Mood swings 1.9 3.4 5.6 -2.3 -2.4 2.1 -0.3 -2.0 -2.0 -2.2 -2.2 -1.9 -1.8 1.2 0.7 -1.6
Loneliness, isolation 0.5 0.8 2.6 -0.9 -1.4 1.5 -0.3 -0.6 -0.1 -0.2 -0.6 -0.7 0.2 0.7 1.6 -0.7
Long-standing illness, disability or infirmity 0.9 1.4 3.5 -1.0 -1.9 1.5 -1.3 -1.4 -1.0 -1.2 -1.4 -1.4 -1.0 0.2 -0.3 -0.7
Ever had bowel cancer screening 1.4 1.6 5.3 -2.3 -2.2 0.8 -0.3 -0.8 -1.1 -1.1 -1.4 -1.7 -1.1 0.8 0.9 0.2
Diabetes diagnosed by doctor 0.3 0.5 2.7 0.3 -0.6 -0.3 -1.5 0.4 0.4 0.3 0.3 -0.0 0.1 -0.6 -1.6 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.4 -0.7 -1.0 -0.7 -1.2 -0.2 0.2 -0.1 -0.2 0.2 0.1 0.7 -0.2 -1.2
Friendships satisfaction 1.2 1.5 7.8 1.5 -0.2 0.7 0.3 1.0 0.6 0.7 0.8 -0.0 0.7 -1.7 -1.7 2.8
Qualifications: nursing, teaching 0.4 0.7 2.6 0.3 0.6 -0.2 -0.5 0.3 0.2 0.3 0.7 0.7 -0.0 -1.6 -1.4 -1.4
Commuting to job workplace: Walk 1.0 1.0 1.6 -0.8 -1.1 0.7 -1.0 -0.9 -1.1 -1.2 -1.1 -1.1 -1.3 0.9 1.2 -0.4
Eye problems/disorders: Cataract 0.5 0.6 2.3 -0.2 -1.1 1.5 -1.2 -0.5 -0.6 -1.0 -0.9 -0.7 -0.5 -0.2 -0.3 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 2.4 0.3 0.0 0.7 -0.8 0.2 0.3 0.2 0.0 -0.1 0.2 1.0 0.5 1.6
Medication for cholesterol 5.6 8.4 14.7 2.7 2.9 -1.7 3.0 3.5 3.2 3.3 3.7 3.8 3.2 -1.4 -1.9 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 -0.3 0.1 -0.1 0.2 -0.2 0.3 0.2 -0.1 -0.2 0.4 0.3 0.6 0.0
Back pain experienced in last month 1.7 2.4 8.7 2.4 1.2 -2.9 -0.7 1.5 1.4 1.5 1.6 1.4 1.7 -0.7 -1.0 0.4
Mineral and other dietary supplements 0.6 0.8 2.6 -0.2 -0.7 1.5 1.4 -0.7 -0.4 -0.4 -0.7 0.1 -0.5 1.0 0.4 -1.6
Breast cancer (self-reported) 0.6 0.7 2.4 -0.1 -1.4 -0.4 -0.1 -0.4 -0.9 -0.8 -0.6 -1.6 -0.3 1.0 1.2 0.2
Asthma (self-reported) 2.0 4.0 8.8 -2.7 -2.8 1.4 -1.4 -2.1 -2.0 -2.2 -2.3 -3.0 -2.0 1.1 0.1 -1.0
Osteoporosis (self-reported) 0.4 0.5 1.9 -0.7 0.1 0.6 0.8 0.2 0.5 0.7 0.1 0.4 0.3 -1.2 -1.4 -0.9
Osteoarthritis (self-reported) 0.4 0.6 5.2 0.2 0.3 0.1 -2.3 -0.4 0.1 -0.1 -0.3 -0.2 -0.0 1.0 0.2 -0.7
Medication: Aspirin 0.6 0.7 3.6 0.7 -0.0 -1.9 -0.3 0.2 0.6 0.7 0.3 1.0 1.0 -0.9 -0.8 -1.1
Medication: Gliclazide 0.4 0.4 1.7 -0.2 -0.3 -0.1 -0.6 0.7 0.3 0.5 0.6 -0.2 0.6 -1.3 -0.5 1.3
Illnesses of father: None of the above (group 1) 1.7 2.1 8.1 -1.7 -1.5 2.8 0.1 -1.8 -1.4 -1.5 -1.4 -1.4 -1.3 1.1 0.5 0.1
Smoking status: Current 2.1 3.3 5.5 2.2 2.3 -1.5 1.1 2.1 2.3 2.1 1.9 2.1 2.4 -0.6 -0.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 2.0 0.1 1.1 0.2 0.6 -0.4 0.3 0.2 0.7 1.2 0.3 0.3 0.0 -1.4
Whole body water mass 0.5 2.7 8.9 1.9 2.4 -3.0 0.8 1.8 1.7 1.4 1.4 1.7 1.3 -0.9 -0.9 -0.3
Leg predicted mass (right) 0.1 0.4 3.2 0.2 0.7 -1.8 0.3 0.3 0.2 -0.0 0.0 -0.0 0.1 0.5 0.2 -0.6
Arm fat mass (left) 1.6 6.7 11.0 -3.0 -2.9 0.8 -2.4 -2.8 -2.6 -2.8 -3.0 -3.3 -2.6 3.1 1.1 -1.8
Number of self-reported non-cancer illnesses 0.8 1.4 5.2 -1.2 -2.3 0.3 -1.5 -0.5 -0.6 -0.8 -1.2 -2.2 -1.1 -0.1 -0.4 0.1
Average weekly champagne plus white wine intake 0.2 0.3 0.8 0.1 -0.1 -0.2 -0.5 -0.4 -0.7 -0.6 -0.2 -0.6 -0.3 -0.7 -0.8 0.9
Miserableness 3.1 5.4 12.2 -2.5 -3.5 2.0 -0.7 -2.4 -2.6 -2.9 -2.7 -3.2 -2.1 1.5 0.6 -1.2
Guilty feelings 1.1 1.7 2.7 -1.5 -1.6 1.2 -0.4 -1.3 -1.3 -1.2 -1.6 -1.3 -1.2 1.4 1.6 -0.4
Wears glasses or contact lenses 0.4 0.4 1.2 -0.1 -0.8 -1.1 -1.1 0.4 -0.1 -0.1 -0.2 -0.3 -0.4 -1.1 -0.9 -0.1
Ever taken oral contraceptive pill 1.0 1.1 1.9 0.7 1.2 -1.3 -0.4 1.0 1.3 1.2 1.3 1.4 1.1 -1.3 0.3 -0.7
Hearing aid user 1.2 1.3 2.9 -1.7 -1.4 0.0 -0.9 -1.5 -0.8 -1.0 -1.1 -1.3 -1.0 1.0 0.8 -1.5
Mother’s age at death 1.0 1.2 8.0 0.3 -0.7 -0.9 0.5 0.3 -0.5 -0.4 -0.2 -0.4 -0.3 -0.8 -2.8 2.2
Financial situation satisfaction 0.4 0.5 1.5 1.2 0.9 0.5 0.5 0.7 0.9 0.8 0.9 0.0 0.8 -0.1 0.0 0.1
Tinnitus: Yes, now most or all of the time 1.2 1.4 6.1 -2.1 -1.9 0.1 -1.0 -0.2 -0.0 -0.1 -1.0 -1.2 -0.6 2.5 0.5 -0.2
Commuting to job workplace: Public transport 1.7 2.1 4.7 1.1 1.3 0.2 1.8 1.6 1.5 1.7 2.2 1.5 1.5 -0.1 -1.3 1.5
Eye problems/disorders: Glaucoma 18.9 22.4 41.7 -6.2 -6.5 2.1 -3.6 -5.2 -5.7 -5.7 -5.6 -6.2 -5.5 1.6 0.3 -0.4
Medication: Blood pressure 2.7 5.1 8.1 -2.1 -2.1 1.2 -1.6 -2.8 -2.6 -2.6 -2.8 -2.7 -2.4 1.0 2.3 -2.1
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.9 -0.4 -0.7 -0.4 -0.7 -1.2 -1.2 -1.3 -1.4 -0.8 -0.5 -0.2 -0.3 0.9
Supplements: Fish oil (including cod liver oil) 0.9 1.2 5.9 0.8 1.3 -1.0 -1.4 0.7 0.4 0.4 0.6 0.1 0.3 -2.4 -1.3 1.1
High cholesterol (Self-reported) 0.2 0.4 2.3 -0.2 -0.5 -0.8 -0.9 0.4 0.5 0.4 0.3 0.3 -0.3 -0.4 -1.5 -0.6
Medication: Bendroflumethiazide 4.3 6.5 11.9 -2.2 -1.4 0.9 -2.4 -2.9 -3.0 -3.0 -3.2 -2.7 -3.0 1.4 3.5 -2.2
Medication: Paracetamol 1.0 1.6 4.4 -0.9 -1.3 2.1 -1.3 -1.2 -0.9 -1.0 -0.9 -1.3 -0.8 1.4 1.8 -0.5
Medication: Lisinopril 0.1 0.1 0.7 -0.4 -0.1 0.4 -0.8 -0.2 0.2 0.3 -0.0 0.1 -0.1 -0.7 -0.5 -0.0
Medication: Atorvastatin 0.3 0.3 1.2 -0.1 0.0 -0.9 -0.6 0.3 0.5 0.5 0.3 0.4 0.0 -0.6 -0.8 -1.1
Illnesses of father: High blood pressure 0.8 1.0 2.6 -0.5 -0.3 -0.5 -1.6 -0.5 -1.4 -1.2 -1.0 -1.2 -1.0 0.3 0.2 1.6
Alcohol drinker status: Never 0.5 0.6 1.3 -0.0 -0.8 0.5 -0.0 -1.2 -1.2 -1.1 -0.8 -1.0 -0.6 0.3 0.2 -0.4
Ever smoked 1.1 1.9 4.8 1.4 1.1 -2.2 0.5 2.0 1.4 1.5 1.4 0.5 0.9 -1.6 -1.6 0.6
Basal metabolic rate 0.3 1.5 7.2 1.3 1.8 -2.7 0.4 1.1 1.1 0.9 0.8 1.1 0.8 -0.3 -0.6 -0.7
Leg fat percentage (left) 1.9 6.8 11.2 -2.9 -3.4 1.1 -3.1 -3.0 -2.8 -2.8 -3.0 -3.2 -2.5 1.9 0.8 -2.2
Arm fat-free mass (left) 0.7 3.4 9.0 2.2 2.4 -3.0 0.6 1.9 2.0 1.8 1.6 2.0 1.6 -1.4 -1.5 -0.5
Number of operations (self-reported) 0.3 0.4 2.0 0.3 -0.1 -1.4 -0.5 0.3 0.7 0.6 0.5 0.1 1.1 0.3 0.9 -0.0
Average weekly beer plus cider intake 0.5 0.8 3.3 1.3 1.2 1.8 -0.6 -0.3 0.2 0.1 -0.2 -0.1 -0.1 0.3 1.3 -1.2
Irritability 0.6 1.0 4.5 -0.8 -1.3 1.1 -0.2 -0.7 -1.0 -1.0 -0.6 -0.4 -0.4 -2.1 -0.1 -1.2
Risk taking 1.0 1.5 4.2 -0.9 -1.4 0.8 -1.4 -0.8 -1.0 -1.0 -1.3 -0.8 -1.1 1.7 0.4 -2.0
Ever had prostate specific antigen (PSA) test 1.2 1.4 2.3 -1.2 -1.5 -0.2 -1.3 -1.1 -1.2 -1.1 -1.4 -1.5 -1.5 0.3 0.8 -1.2
Fractured/broken bones in last 5 years 1.1 1.4 5.8 -0.7 -1.5 0.2 -1.4 -0.7 -0.9 -1.1 -1.3 -2.4 -1.3 0.3 0.8 -1.0
Age started oral contraceptive pill 1.6 2.0 8.5 0.8 1.0 -1.1 1.2 1.3 1.4 1.4 1.3 1.0 1.1 -2.9 -1.8 0.3
Diastolic blood pressure, automated reading 0.1 0.5 2.9 0.6 -0.2 -0.8 -0.9 -0.2 -0.3 -0.6 -0.3 -0.2 -0.0 -0.7 0.3 -1.7
Ever depressed for a whole week 1.1 1.4 5.8 -1.3 -1.6 0.8 -0.6 -0.5 -0.6 -0.6 -0.6 -1.5 -0.3 2.4 1.7 0.3
Unable to work because of sickness or disability 0.7 0.9 3.2 -1.0 -1.1 0.1 -1.8 -1.1 -0.9 -1.0 -1.3 -0.3 -0.5 0.8 0.2 -0.7
Commuting to job workplace: Cycle 0.7 0.8 5.3 1.1 0.9 -0.2 -0.6 0.8 0.2 0.2 0.4 1.0 0.2 -2.3 -0.9 0.2
Myopia 0.2 0.3 1.3 -0.5 -1.0 -0.4 0.5 0.3 -0.1 -0.2 0.1 -0.4 -0.2 -1.1 -0.6 0.6
Vascular/heart problems diagnosed by doctor 1.0 2.6 4.4 1.6 2.0 -0.7 1.3 1.8 1.6 1.7 2.1 2.0 1.9 -0.4 -1.0 1.8
Cholesterol lowering medication 0.6 0.9 4.4 -0.5 -0.0 -0.7 -1.6 -1.0 -0.6 -0.7 -0.7 -0.7 -0.9 -0.9 -0.3 -2.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 1.0 0.8 -0.0 0.6 -0.1 0.5 0.2 0.3 0.1 -0.6 0.5 0.1 -1.0 -0.2
Pain experienced in last month 1.5 2.6 7.3 0.6 0.9 0.3 2.7 1.8 1.6 1.7 1.9 1.8 0.8 -2.2 -1.9 0.8
Supplements: Calcium 1.7 1.9 5.3 -1.3 -1.1 1.1 -1.9 -1.2 -1.0 -1.0 -1.3 -2.3 -1.3 1.4 0.8 -1.2
Basal cell carcinoma (self-reported) 0.3 0.4 1.9 0.1 0.6 0.3 0.0 0.3 0.8 0.8 0.2 0.1 0.6 1.4 0.7 0.1
Heart attack/myocardial infarction (self-reported) 1.8 2.4 5.9 2.4 2.0 -1.3 0.5 1.6 1.7 1.6 1.4 2.2 1.4 -1.3 -0.5 -0.6
Deep venous thrombosis (DVT) (self-reported) 3.1 3.9 7.7 -2.3 -2.8 1.4 -0.7 -1.7 -1.7 -1.8 -2.3 -2.3 -1.9 2.6 2.0 -1.2
Heart disease (siblings) 0.4 0.6 2.3 -0.1 0.4 0.1 0.2 0.6 1.0 0.9 0.8 0.8 1.0 -1.5 -0.6 0.2
Alcohol drinker status: Previous 0.3 0.4 1.9 -0.5 -0.6 -0.1 -0.5 -0.3 -0.2 -0.2 -0.2 -0.5 -0.3 1.4 1.1 0.3
Pack years of smoking 0.9 1.4 4.4 -1.5 -1.8 0.8 -2.1 -0.5 -0.5 -0.6 -0.8 -1.1 -1.1 1.4 1.1 -0.6
Impedance of whole body 0.1 0.5 1.8 0.3 0.5 1.4 0.9 0.2 0.2 0.4 0.4 0.4 0.3 0.4 1.2 1.0
Leg fat mass (left) 1.0 4.0 6.4 -2.2 -2.2 0.4 -2.2 -2.1 -2.0 -2.1 -2.3 -2.5 -2.0 1.9 0.7 -2.0
Arm predicted mass (left) 0.5 2.8 9.4 2.0 2.1 -3.1 0.4 1.7 1.8 1.5 1.4 1.7 1.4 -1.1 -1.2 -0.4