Hub : Genes

AFAP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.6050	0.1060	2.7e-06	0.285	NA	0.223	NA	0.344	5.2e-08	NA	2.1e-06	NA	1.2e-09
2	GTEx	Brain Cerebellum	0.4670	0.1010	2.0e-04	0.194	NA	0.110	NA	0.190	2.1e-06	NA	3.8e-04	NA	2.8e-06
3	GTEx	Cells Transformed fibroblasts	0.2630	0.0530	4.1e-07	0.097	NA	0.133	NA	0.120	1.1e-07	NA	3.6e-10	NA	2.8e-09
4	GTEx	Colon Transverse	0.2820	0.0890	2.5e-03	0.004	NA	0.035	NA	0.006	2.0e-01	NA	8.8e-03	NA	1.6e-01
5	GTEx	Esophagus Mucosa	0.4750	0.0590	1.7e-16	0.403	NA	0.430	NA	0.429	1.0e-28	NA	3.9e-31	NA	4.8e-31
6	GTEx	Skin Not Sun Exposed Suprapubic	0.4670	0.0610	1.1e-14	0.460	NA	0.428	NA	0.453	7.0e-28	NA	2.2e-25	NA	2.8e-27
7	GTEx	Skin Sun Exposed Lower leg	0.5020	0.0500	0.0e+00	0.453	NA	0.425	NA	0.460	2.4e-41	NA	4.7e-38	NA	4.2e-42
8	GTEx	Whole Blood	0.4470	0.0410	0.0e+00	0.480	NA	0.500	NA	0.490	9.4e-50	NA	1.3e-52	NA	3.4e-51
9	METSIM	Adipose	0.0505	0.0221	1.1e-02	0.029	0.010	0.032	0.019	0.024	3.4e-05	9.8e-03	1.3e-05	5.8e-04	1.3e-04
10	NTR	Blood	0.1291	0.0184	0.0e+00	0.122	0.108	0.124	0.126	0.128	3.2e-37	5.7e-33	8.8e-38	2.2e-38	3.1e-39
11	TCGA	Liver Hepatocellular Carcinoma	0.0820	0.0390	8.6e-03	0.001	-0.005	-0.006	NA	-0.002	2.7e-01	7.0e-01	9.6e-01	NA	4.0e-01
12	TCGA	Pheochromocytoma and Paraganglioma	0.2240	0.0830	7.8e-04	0.126	0.087	0.055	NA	0.054	1.1e-05	2.6e-04	3.1e-03	NA	3.4e-03
13	TCGA	Thyroid Carcinoma	0.1510	0.0420	1.9e-09	0.141	0.098	0.139	NA	0.149	1.3e-13	9.7e-10	1.9e-13	NA	2.2e-14

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.4	0.6	1.9	1.4	0.2	-1.3	0.1	0.9	0.8	0.8	0.9	0.3	0.3	-1.0	-0.2	-0.1
Bipolar Disorder or Schizophrenia	0.1	0.2	0.9	1.0	-0.1	-0.8	-0.2	0.3	-0.1	-0.0	0.1	-0.1	-0.6	-0.7	-0.7	0.1
Depressed Affect (Nagel 2018)	1.6	3.3	11.4	-2.3	-3.4	1.8	0.7	-1.4	-1.6	-1.6	-1.8	-2.3	-1.1	1.7	1.2	-1.0
Depression (Nagel 2018)	0.5	0.8	1.5	-0.6	-1.1	0.5	1.0	-1.0	-1.1	-1.1	-1.1	-0.5	-0.3	1.2	0.5	0.2
Intelligence (Savage-Jansen 2018)	1.6	4.8	10.9	1.8	1.3	-0.2	0.8	2.8	3.0	3.0	2.9	3.3	2.3	-0.9	-1.9	1.4
Neuroticism (Nagel 2018)	1.9	4.4	8.5	-2.0	-2.9	2.0	-0.8	-2.5	-2.5	-2.5	-2.5	-2.6	-1.9	1.4	1.1	-1.1
Schizophrenia (2018)	0.1	0.3	1.1	0.2	-0.3	0.3	-0.6	-0.4	-0.6	-0.6	-0.6	-0.3	-1.1	-0.1	-0.6	0.2
Schizophrenia vs Biploar Disorder	0.4	0.5	2.7	0.9	1.2	-0.5	1.6	0.5	0.6	0.4	0.3	0.6	0.5	-0.6	0.3	-0.1
Worry (Nagel 2018)	0.9	1.9	3.6	-0.8	-0.9	1.6	-1.2	-1.9	-1.9	-1.9	-1.8	-1.9	-1.3	-0.1	0.2	-0.1
Alzheimer’s Disease (in mother)	0.4	0.5	2.4	0.5	0.9	-1.6	-1.2	0.3	0.3	0.3	0.3	0.5	0.3	-0.6	-0.3	0.5
Alzheimer’s Disease (in father)	1.2	1.3	3.2	-0.9	-0.7	0.7	-1.8	-1.3	-1.3	-1.2	-1.0	-0.8	-1.1	1.6	1.1	0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	2.2	-0.2	0.3	-1.2	-1.5	-0.2	-0.4	-0.5	-0.4	-0.1	-0.4	0.7	0.9	0.3
Crohns Disease (2017)	0.3	0.7	2.0	-0.8	-1.2	1.4	-0.3	0.1	-0.2	-0.2	-0.6	-1.3	-0.5	1.2	0.0	0.9
Irritable Bowel Disease (IBD)	0.6	1.5	4.6	-1.9	-2.1	1.9	-1.2	-0.3	-0.4	-0.4	-0.9	-1.1	-0.6	1.6	0.4	0.4
Ulcerative Colitis (UC)	1.0	2.0	5.4	-2.3	-2.3	1.4	-1.9	-0.8	-0.9	-0.9	-1.3	-0.9	-1.0	1.7	0.6	-0.1
Major Depression (MDD)	1.2	1.4	8.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	2.3	2.3	-2.8
Reaction Time	0.5	0.9	4.6	-1.1	0.1	1.3	2.1	-1.0	-0.4	-0.3	-0.4	0.0	0.4	0.5	1.6	-0.2
Verbal and Numeric Reasoning (VNR)	1.3	3.1	6.5	0.9	0.2	1.0	1.8	2.3	2.5	2.4	2.2	2.1	2.1	-0.7	-0.8	1.5
Breast Cancer	0.7	1.8	4.2	1.3	1.3	-0.8	0.4	1.6	1.6	1.6	2.0	2.0	1.5	-0.4	-0.8	0.5
Ovarian Cancer	0.2	0.3	1.4	-0.2	-0.3	-0.8	1.2	0.5	-0.0	0.0	-0.1	-0.3	-0.4	0.1	0.7	-0.9
Prostate Cancer	0.9	1.3	7.6	0.6	0.4	0.5	0.1	0.9	0.9	0.8	0.7	0.0	0.6	-0.5	-2.1	2.8
Age at First Birth	0.8	1.1	6.6	1.0	1.0	-0.6	0.4	0.3	0.6	0.7	0.6	1.6	0.3	-2.6	-1.4	-0.2
Bipolar Disorder (2011)	0.8	0.8	4.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.7	-2.1	1.9
Body Mass Index (BMI) (2010)	0.7	0.9	1.6	-1.2	-0.9	-1.2	-1.0	-1.2	-1.0	-1.1	-0.9	0.2	-0.9	0.4	0.5	-1.1
Coronary Artery Disease (CAD)	2.0	2.3	6.5	-2.0	-1.6	1.5	-0.6	-2.1	-1.5	-1.5	-1.5	-0.9	-1.2	-0.9	0.5	-2.6
Crohns Disease (2012)	1.5	2.3	4.6	1.8	1.3	0.3	0.5	2.2	2.1	2.1	1.7	1.1	1.7	-0.6	-0.9	2.0
Mean Putamen Volume	0.8	0.9	1.8	-0.8	-0.5	0.8	-0.4	-1.3	-1.3	-1.3	-1.4	-0.9	-1.1	-0.2	0.4	-0.9
Fasting Glucose	0.3	0.3	1.7	0.4	0.1	0.6	-1.3	0.9	0.5	0.3	0.2	0.2	-0.1	0.8	0.6	0.2
HbA1C	2.3	2.6	5.0	-1.1	-1.9	0.9	-1.7	-1.8	-1.8	-1.9	-1.7	-2.2	-1.8	-0.1	1.2	-1.6
HDL Cholesterol	0.2	0.4	2.5	0.4	0.4	0.7	1.6	-0.5	-0.6	-0.5	0.0	0.6	-0.1	0.3	0.3	-0.1
LDL Cholesterol	0.3	0.4	1.8	0.4	0.5	-0.6	-1.3	0.5	0.5	0.4	0.7	1.2	0.6	-0.0	-0.3	0.3
Lupus	1.2	1.8	4.0	-0.9	-1.4	1.1	-0.5	-1.6	-2.0	-2.0	-1.9	-1.7	-1.6	0.3	0.3	0.2
Neuroticism (2016)	0.4	0.6	2.5	-1.5	-1.4	0.8	1.6	-0.2	-0.2	-0.2	0.0	-0.2	0.5	0.5	0.3	-0.2
Primary Biliary Cirrhosis	0.6	0.8	1.9	-1.4	-1.3	1.3	-0.3	-0.4	-0.8	-0.9	-0.5	-1.4	-0.8	0.4	-0.8	0.6
Rheumatoid Arthritis	2.6	3.5	5.9	1.5	2.2	0.1	0.4	1.8	2.1	2.1	2.4	2.3	2.3	-2.3	-1.4	1.7
Schizophrenia (2014)	0.2	0.4	1.3	0.5	0.3	-1.1	-0.5	-0.3	-0.4	-0.5	-0.4	0.0	-1.0	-0.9	-0.2	-0.8
Triglycerides	0.4	0.7	2.1	-0.8	-1.2	-0.3	-1.4	-0.6	-0.6	-0.7	-0.9	-0.6	-0.5	0.5	1.5	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	-0.1	-0.3	-0.3	-0.4	-0.1	0.3	0.2	0.3	0.1	0.7	0.7	0.5	0.0
Ulcerative Colitis	0.9	1.3	3.5	-0.8	-1.3	-0.5	-1.5	1.4	1.4	1.2	0.8	1.2	1.1	-0.0	-1.9	0.2
Blood Eosinophil Count	0.8	5.9	8.9	-2.3	-2.8	1.5	-2.6	-2.3	-2.9	-3.0	-3.0	-2.7	-2.9	1.4	1.7	-1.6
Blood Platelet Count	0.1	1.4	8.5	1.2	0.3	-1.5	-1.5	-0.4	-0.2	-0.3	-0.9	0.5	0.0	1.5	2.9	-0.9
Blood Red Count	0.2	1.6	9.4	1.1	0.5	-1.4	0.5	1.2	0.3	0.4	0.3	0.3	-0.5	-3.1	-2.1	-1.1
Blood White Count	0.2	1.2	8.1	-0.2	-1.1	-1.0	-1.0	0.3	-0.1	-0.1	-0.3	-0.2	-0.2	-2.8	-1.8	0.0
Heel T-Score	0.5	3.7	10.2	-0.5	1.1	2.8	-1.8	-2.6	-1.5	-1.7	-1.6	0.1	-0.9	1.3	2.8	-3.2
BMI	0.9	5.2	8.5	-2.2	-1.9	1.4	-1.9	-2.7	-2.6	-2.7	-2.9	-2.9	-2.5	1.7	0.9	-2.4
Height	2.3	43.7	74.0	8.5	8.6	-6.6	4.3	8.0	7.7	7.5	7.2	8.2	6.4	-3.7	-2.3	1.4
Waist Hip Ratio (WHR)	1.6	7.0	12.4	-2.3	-2.9	3.5	-0.6	-2.8	-3.0	-2.7	-3.0	-3.5	-2.9	1.8	2.5	0.8
Systolic Blood Pressure	3.8	19.1	34.8	5.8	5.9	-2.6	2.2	4.3	4.4	4.5	4.8	5.1	4.3	-5.9	-2.7	1.0
Smoking Status	1.2	2.8	5.0	2.2	2.0	-2.1	0.6	2.1	2.1	2.0	1.6	1.6	1.9	-1.2	-0.2	-0.0
Allergy or Eczema	0.7	2.0	5.3	-0.8	-0.7	0.2	-0.1	-1.1	-1.9	-1.9	-1.6	-2.0	-1.8	0.4	0.4	2.3
Cardiovascular Disease	0.9	2.8	5.0	-1.1	-1.5	1.4	-1.1	-2.1	-1.8	-2.0	-2.2	-2.2	-2.1	1.3	-0.0	-1.5
Hypothyroidism (self reported)	0.7	1.6	3.5	-1.9	-1.7	0.6	-0.5	-1.3	-1.4	-1.5	-1.5	-1.5	-1.4	-0.9	-1.1	0.4
Respiratory disease	2.6	5.8	10.4	-2.7	-2.6	2.6	-1.8	-2.8	-2.6	-2.7	-2.9	-3.2	-2.3	1.7	0.8	-1.5
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.7	0.2	-0.7	1.1	-1.6	-0.4	-0.3	-0.4	-0.4	-0.4	-0.7	0.0	-0.6	-0.2
Lung FEV1/FVC ratio	4.4	22.2	49.1	6.3	7.0	-3.6	1.5	4.1	4.8	4.6	5.3	6.4	4.8	-5.0	-2.8	-0.2
Lung FVC	0.9	4.3	13.9	-2.2	-0.4	2.6	0.7	-2.3	-1.4	-1.6	-1.2	0.3	-1.4	2.8	3.0	-3.7
Neuroticism	3.8	9.1	14.3	-3.1	-3.7	3.5	-1.7	-3.5	-3.5	-3.4	-3.5	-3.8	-3.0	1.8	1.7	-1.7
Chronotype (morning person)	0.3	0.7	3.3	0.2	0.5	-1.2	-0.3	0.4	0.7	0.6	0.6	0.9	0.8	-1.8	0.2	0.6
Hair Pigment	0.0	0.5	1.1	0.3	0.0	-0.2	1.0	1.0	0.9	1.0	0.7	0.7	1.0	-0.6	-0.1	0.9
Tanning	0.0	0.3	1.7	0.4	0.3	-1.3	0.4	0.1	-0.2	-0.2	-0.2	0.1	-0.3	0.1	0.7	-0.7
Hand grip strength (left)	4.1	10.9	21.3	4.2	4.6	-2.1	2.7	3.5	3.4	3.5	3.8	4.6	3.4	-1.9	-1.2	1.3
Number of treatments/medications taken	1.8	3.2	7.0	-2.1	-2.7	2.4	-1.8	-1.7	-1.5	-1.5	-1.8	-2.6	-1.4	1.0	0.4	0.3
Average weekly spirits intake	8.0	10.0	15.2	-3.5	-3.4	2.3	-2.2	-3.4	-3.3	-3.1	-3.9	-3.4	-3.6	3.6	2.6	-2.1
Sensitivity / hurt feelings	0.9	1.5	2.6	-0.8	-1.2	1.2	-1.5	-1.3	-1.5	-1.6	-1.6	-1.4	-1.4	0.9	0.1	-0.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.5	-0.5	-0.9	-0.0	0.8	-0.8	-1.2	-1.2	-1.0	-0.6	-0.4	0.6	0.2	-0.1
Hearing difficulty/problems: Yes	3.4	5.2	15.8	-4.0	-3.2	0.5	-1.8	-2.2	-1.8	-1.9	-2.3	-3.0	-1.6	2.2	1.8	-0.9
Relative age of first facial hair	0.1	0.2	0.8	0.7	0.4	0.9	-0.9	0.1	-0.1	-0.1	0.4	-0.1	0.2	-0.4	-0.5	0.2
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	5.8	-1.7	-2.3	1.5	-2.4	-1.1	-1.1	-1.3	-1.8	-1.4	-1.4	-0.4	-1.2	-0.9
Ever used hormone-replacement therapy (HRT)	1.1	1.3	4.4	-1.8	-2.1	0.0	-1.2	-0.9	-0.8	-0.9	-1.3	-1.7	-0.7	1.0	-0.0	0.5
Ever had hysterectomy (womb removed)	0.3	0.4	1.0	0.9	0.9	-1.0	-0.8	0.1	0.1	0.1	-0.1	0.6	0.3	-0.8	-0.7	0.4
Systolic blood pressure, automated reading	2.2	6.5	14.4	3.3	2.9	-2.0	0.1	2.7	2.4	2.3	2.8	2.7	2.2	-3.8	-2.7	1.3
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	6.6	-2.0	-2.6	1.2	-2.2	-2.0	-1.9	-2.0	-2.1	-1.9	-2.0	1.7	0.3	0.8
Angina	3.3	4.3	11.5	1.4	1.9	-3.4	2.1	1.6	2.1	2.2	2.2	2.5	2.7	-2.2	-0.4	0.1
Medication for hormone replacement therapy	1.3	1.5	2.9	-1.0	-1.2	1.5	-1.5	-1.2	-1.1	-1.3	-1.5	-1.7	-1.6	0.3	0.4	-0.1
Vitamin and mineral supplements	0.6	0.8	1.9	1.2	0.5	-1.0	1.4	1.1	0.9	0.8	1.1	0.9	0.8	-0.5	-0.5	0.8
Supplements: Zinc	0.3	0.3	1.6	-0.0	0.7	0.7	1.3	-0.7	-0.3	-0.3	-0.4	-0.3	-0.4	0.3	0.3	-0.8
Medication: Co-codamol	1.8	2.1	4.5	-1.4	-0.9	1.6	-2.1	-2.0	-1.4	-1.6	-1.4	-1.2	-1.3	1.2	0.1	-1.5
Medication: Metformin	0.9	1.3	4.4	-0.9	-1.6	0.3	-2.1	-1.2	-1.1	-1.1	-1.2	-1.3	-0.9	0.3	-0.3	1.1
Diabetes (father)	1.6	2.0	3.3	-1.0	-0.1	1.6	-0.8	-1.7	-1.4	-1.6	-1.3	-1.3	-1.6	1.6	1.8	-1.6
Diabetes (mother)	1.9	2.4	4.5	-2.1	-1.9	1.7	-0.6	-1.5	-1.4	-1.4	-1.7	-2.1	-1.7	1.6	0.7	-0.4
Severe depression (siblings)	5.7	6.4	10.0	3.2	3.1	-1.7	2.7	2.7	2.4	2.6	2.7	2.7	2.5	-1.9	-1.9	2.4
Pack years adult smoking proportion	0.9	1.3	4.3	-1.2	-1.6	0.9	-2.1	-0.6	-0.6	-0.7	-0.8	-1.1	-1.0	1.5	1.1	-0.7
Impedance of leg (right)	0.5	2.6	6.0	2.4	2.3	-0.3	0.9	1.6	1.6	1.7	1.8	2.3	1.4	-1.4	-0.5	0.6
Leg fat-free mass (left)	0.1	0.5	4.3	0.3	0.8	-2.1	0.2	0.4	0.3	0.0	0.1	0.1	0.0	0.6	-0.1	-0.7
Trunk fat percentage	2.1	8.5	13.8	-3.7	-3.5	1.6	-2.3	-3.0	-2.9	-3.0	-3.2	-3.6	-2.7	3.5	2.1	-1.5
Hand grip strength (right)	3.4	9.3	20.7	3.9	4.6	-1.0	2.9	3.2	3.2	3.2	3.6	4.0	3.2	-1.0	-1.1	1.8
Townsend deprivation index at recruitment	0.9	1.3	8.5	-0.9	0.0	1.3	0.5	-1.0	-0.5	-0.5	-1.1	-1.0	0.0	1.4	2.9	-0.6
Current tobacco smoking	1.6	2.5	5.1	2.0	1.8	-1.0	1.3	1.9	2.1	2.0	1.7	1.8	2.3	-0.3	0.3	-0.1
Average weekly fortified wine intake	0.6	0.7	2.9	-1.0	-1.0	0.4	-0.5	-0.5	-0.7	-0.7	-0.1	-0.3	-0.3	-1.6	-1.7	0.2
Maternal smoking around birth	0.2	0.3	1.3	-0.2	-0.5	-0.3	-0.7	-0.3	-0.2	-0.3	-0.4	-0.0	-0.8	1.1	-0.6	-0.2
Fed-up feelings	3.0	5.4	12.0	-2.3	-3.5	2.6	0.1	-2.2	-2.2	-2.3	-2.5	-3.0	-1.9	2.3	1.7	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.4	-1.4	-1.9	0.9	0.1	-1.6	-1.2	-1.3	-1.4	-1.4	-0.5	1.7	1.1	-0.3
Relative age voice broke	0.4	0.7	1.3	0.8	0.8	1.0	-0.8	1.0	0.8	0.7	1.1	0.9	0.7	-0.8	-0.5	0.2
Taking other prescription medications	1.7	2.6	8.4	-1.2	-2.6	1.2	-1.5	-1.4	-1.5	-1.5	-2.1	-2.9	-1.5	0.6	0.0	0.0
Age when periods started (menarche)	0.1	0.3	1.6	0.3	-0.0	0.3	1.3	0.2	-0.2	-0.1	0.0	0.2	0.0	0.1	-1.0	1.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.2	0.3	1.1	-0.2	-0.1	-0.3	0.2	-0.1	0.1	-0.1	0.3	-0.8	0.3	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	5.3	-0.6	0.4	0.1	-1.2	-1.0	-0.3	-0.4	-0.3	-0.3	-0.5	1.4	2.3	-1.6
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	4.0	-0.7	-0.7	0.6	-2.0	-1.0	-1.1	-1.4	-1.3	-1.8	-1.1	-0.0	0.8	-0.5
Qualifications: CSEs or equivalent	0.9	1.1	1.9	-0.1	-0.7	1.1	0.3	-1.4	-1.3	-1.3	-1.0	-1.3	-1.0	1.4	0.8	-1.1
Serious illness, injury or assault to yourself	0.3	0.3	1.6	-0.5	-1.0	-1.2	0.0	0.6	0.2	0.1	-0.0	-0.1	-0.2	-0.1	-0.8	0.3
High blood pressure	1.2	3.2	5.6	-1.8	-2.1	0.8	-1.4	-2.0	-2.0	-2.1	-2.4	-2.2	-2.3	0.5	1.1	-1.6
Hayfever, allergic rhinitis or eczema	0.5	1.1	4.2	0.0	-0.0	0.8	1.0	-0.6	-1.3	-1.4	-0.9	-1.4	-1.1	0.6	-0.0	2.0
Multivitamins +/- minerals	0.2	0.3	0.9	0.3	0.7	0.2	-1.0	0.2	0.3	0.4	0.4	0.5	0.3	-0.9	-0.6	-0.0
Stomach or abdominal pain in last month	0.5	0.6	1.5	-0.2	-1.1	-0.0	-1.0	-0.7	-0.9	-0.9	-0.9	-1.2	-0.7	0.1	0.5	-0.7
Supplements: Glucosamine	0.4	0.6	3.7	0.5	0.4	-1.1	-1.9	0.8	0.6	0.5	0.5	0.6	0.2	0.1	-0.5	0.2
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	4.9	-0.5	0.3	1.4	1.2	-0.4	-0.5	-0.5	-0.3	-0.5	-0.1	1.2	2.2	-0.5
Medication: Atenolol	0.5	0.6	1.7	0.9	0.4	0.3	0.2	1.0	1.2	1.3	0.8	0.8	1.2	-0.5	0.2	0.1
Medication: Levothyroxine sodium	0.6	1.0	3.2	-1.3	-1.8	0.0	-1.2	-0.8	-0.8	-0.9	-1.1	-0.8	-1.0	-0.4	-1.1	0.1
Sitting height	2.7	19.2	35.8	5.0	5.2	-6.0	2.9	5.4	5.0	4.8	4.8	5.3	4.2	-2.1	-1.5	0.2
Chronic bronchitis/emphysema (father)	0.2	0.2	1.6	0.3	-0.2	0.0	-0.3	0.3	0.4	0.3	0.1	0.3	-0.3	0.5	0.6	-1.3
High blood pressure (mother)	0.2	0.3	0.8	0.9	0.8	-0.9	0.4	-0.2	0.2	0.3	0.4	0.2	0.1	-0.4	0.5	-0.7
Body mass index (BMI)	2.3	9.7	14.9	-3.8	-3.8	1.2	-2.8	-3.5	-3.3	-3.5	-3.6	-3.9	-3.2	3.0	0.8	-2.3
Impedance of leg (left)	0.4	1.9	3.9	2.0	1.9	0.5	0.8	1.2	1.3	1.4	1.5	1.9	1.4	-1.3	0.3	0.8
Leg predicted mass (left)	0.1	0.5	4.2	0.2	0.7	-2.0	0.2	0.5	0.3	0.1	0.1	0.1	0.0	0.7	-0.1	-0.6
Trunk fat mass	1.0	4.2	6.9	-2.6	-2.4	0.5	-1.7	-2.1	-2.0	-2.1	-2.3	-2.6	-2.0	2.5	1.3	-1.5
Waist circumference	1.5	5.3	10.9	-2.6	-3.0	0.9	-1.8	-2.5	-2.5	-2.5	-2.7	-3.3	-2.5	2.0	0.7	-1.2
Number of incorrect matches in round	0.2	0.3	1.7	-0.4	-0.3	-0.7	1.3	0.3	-0.1	-0.0	-0.1	-0.4	-0.4	-0.1	1.1	0.2
Past tobacco smoking	0.9	1.7	4.9	-1.0	-0.7	2.2	-0.4	-1.9	-1.2	-1.3	-1.3	-0.6	-0.8	1.9	1.4	-0.6
Alcohol usually taken with meals	0.9	1.4	4.3	0.4	0.2	-1.1	0.3	1.4	0.8	1.2	1.2	0.4	0.9	-1.9	-1.5	2.1
Nervous feelings	0.2	0.3	0.9	0.3	0.4	0.9	0.7	-0.6	-0.6	-0.6	-0.4	-0.7	-0.2	-0.9	-0.6	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.9	-1.3	-1.7	0.9	0.3	-1.4	-1.5	-1.4	-1.2	-1.3	-0.3	0.3	1.1	0.4
Hearing difficulty/problems with background noise	1.1	1.8	5.7	-2.2	-1.7	-1.1	-1.5	-1.0	-1.0	-1.2	-1.3	-2.4	-0.8	0.4	0.8	0.8
Hair/balding pattern: Pattern 2	0.8	1.0	2.3	-0.7	-0.9	1.1	-1.2	-1.1	-1.3	-1.2	-1.0	-0.6	-1.5	0.6	0.6	-0.8
Had menopause	0.8	1.0	2.6	-1.2	-1.4	0.6	-0.2	-0.8	-1.1	-0.9	-1.1	-1.4	-0.8	-0.0	0.2	1.6
Had other major operations	0.4	0.5	1.7	-0.6	-1.3	-1.1	-1.0	-0.2	-0.2	-0.1	-0.5	-0.9	0.2	0.8	-0.2	0.0
Forced vital capacity (FVC)	1.2	4.7	18.3	2.5	4.3	-1.3	2.7	1.5	1.7	1.7	2.1	3.5	1.3	-0.3	0.0	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	5.3	-0.7	0.3	0.3	-1.5	-1.4	-0.8	-0.8	-0.8	-0.3	-0.9	2.0	2.3	-0.8
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	2.6	-0.7	-1.6	1.2	-0.9	-0.3	-0.5	-0.6	-0.7	-1.2	-0.5	1.6	1.5	-0.9
Qualifications: None of the above	1.1	2.4	5.2	-2.2	-2.0	2.3	-0.8	-1.6	-1.3	-1.3	-1.7	-1.4	-1.0	1.2	1.7	-0.2
Financial difficulties in last 2 years	0.5	0.7	1.8	1.3	1.2	0.2	-0.6	0.5	0.8	0.7	0.4	1.0	0.7	-0.1	0.3	-1.4
Mouth/teeth dental problems	3.0	4.6	8.4	2.1	2.3	-2.9	2.6	2.0	2.1	2.1	2.3	2.6	1.8	-2.0	-1.3	-0.6
Heart attack	1.7	2.1	5.8	2.4	1.9	-1.2	0.3	1.5	1.7	1.5	1.4	2.1	1.4	-1.0	-0.3	-0.5
Allergy	0.9	2.1	6.5	0.9	1.3	-1.1	-0.6	1.2	1.7	1.9	1.6	2.5	1.7	-1.3	-0.3	-1.2
Pain all over the body in last month	2.5	2.7	6.9	-2.6	-2.1	1.5	-1.5	-1.2	-1.3	-1.2	-1.5	-1.9	-1.5	2.5	-0.2	-0.1
Diabetes (self-reported)	0.6	1.0	2.9	-0.4	-1.2	-0.1	-1.7	-0.4	-0.7	-0.8	-0.7	-1.4	-0.7	-0.6	-1.4	1.1
Hayfever/allergic rhinitis (self-reported)	2.1	2.7	4.9	2.1	2.2	-0.7	1.7	1.7	1.4	1.2	1.6	1.5	2.0	-2.0	-0.8	1.8
Medication: Ramipril	1.2	1.5	3.1	-1.4	-1.3	0.5	-0.8	-1.7	-1.3	-1.3	-1.4	-1.2	-1.5	0.3	1.2	-1.2
Medication: Simvastatin	0.7	1.1	3.4	0.3	-0.1	-1.9	-1.4	-0.2	-0.3	-0.4	-0.5	-0.5	-0.8	-1.8	-1.4	-1.4
Fluid intelligence score	1.4	3.0	5.2	1.5	1.1	0.9	1.4	2.3	2.3	2.2	2.2	2.0	2.0	-1.1	-1.0	1.6
Illnesses of siblings	1.0	1.4	3.7	0.8	1.3	0.6	1.7	1.6	1.0	1.0	1.4	1.9	0.9	0.5	-1.0	0.9
Neuroticism score	4.0	8.4	12.7	-3.3	-3.5	3.0	-2.0	-3.2	-3.3	-3.3	-3.4	-3.6	-2.7	1.9	2.1	-1.2
Weight	0.2	0.8	2.1	-0.8	-0.6	-1.5	-0.9	-0.6	-0.6	-0.8	-0.9	-0.9	-0.8	1.2	-0.2	-1.1
Impedance of arm (right)	0.3	1.4	3.3	-1.3	-0.7	0.9	-0.1	-1.2	-1.3	-1.1	-0.9	-1.1	-1.3	1.6	1.8	0.7
Arm fat percentage (right)	3.6	14.3	21.9	-4.6	-4.4	1.7	-3.5	-4.1	-4.0	-4.1	-4.3	-4.7	-3.9	4.0	2.0	-2.1
Trunk fat-free mass	1.1	6.3	14.5	3.0	3.5	-3.8	1.2	2.7	2.7	2.4	2.4	2.9	2.2	-1.7	-1.5	-0.1
Hip circumference	0.3	1.2	1.9	-1.2	-1.3	-1.1	-0.9	-1.0	-1.0	-1.1	-1.2	-1.4	-1.0	1.0	-0.8	-0.9
Time employed in main current job	0.1	0.1	0.5	0.4	0.5	0.1	0.6	-0.3	-0.1	-0.2	-0.3	0.1	0.2	-0.0	0.7	-0.2
Alcohol intake versus 10 years previously	0.3	0.4	2.9	-0.2	-0.9	-0.1	-0.0	0.0	0.0	0.0	-0.2	-1.0	-0.2	0.0	-0.7	-1.7
Father’s age at death	0.8	1.1	4.7	0.5	0.4	-0.3	0.7	1.4	0.9	1.1	1.5	1.0	0.9	-0.3	-0.6	2.2
Worrier / anxious feelings	0.7	1.4	3.0	-1.0	-0.7	1.7	-1.7	-1.4	-1.4	-1.4	-1.0	-1.5	-0.7	-0.1	0.1	0.8
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	7.2	-1.7	-2.0	2.7	-0.5	-2.1	-2.0	-2.0	-2.1	-2.6	-1.4	2.2	2.1	-1.1
Falls in the last year	1.8	2.5	11.5	-1.6	-1.9	-0.4	-3.4	-1.2	-1.2	-1.6	-1.6	-1.4	-1.5	1.2	-0.1	-0.4
Hair/balding pattern: Pattern 3	2.3	3.5	6.9	2.2	1.4	-1.2	0.1	2.1	2.1	2.2	2.0	1.7	1.8	-2.4	-2.6	0.5
Number of live births	0.9	1.2	2.6	-1.0	-0.9	0.7	-0.6	-1.0	-1.2	-1.4	-1.4	-1.2	-1.3	1.6	0.7	-0.5
Forced expiratory volume in 1-second (FEV1)	1.8	6.0	24.0	3.0	4.9	-1.4	2.1	1.5	2.0	1.9	2.5	4.1	1.7	-0.7	-0.5	-1.5
Pulse rate	0.5	0.8	3.9	0.3	0.6	2.0	-1.8	-0.8	-0.1	-0.2	-0.1	-0.2	0.0	-1.1	-0.9	-0.1
Happiness	0.9	1.1	8.4	1.0	0.3	0.8	2.9	0.5	0.2	0.1	0.5	0.3	0.7	-0.5	-0.2	1.6
Noisy workplace	2.6	3.2	6.6	-2.1	-1.5	2.6	-1.4	-1.9	-1.5	-1.5	-2.2	-2.4	-1.7	1.1	1.7	-1.2
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.2	1.4	1.5	-0.8	1.8	1.6	1.0	1.1	1.8	1.8	0.9	-1.7	-0.4	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.7	0.6	0.0	-0.8	-0.4	0.0	-0.1	-0.0	0.3	0.8	0.0	0.2	0.3	0.4
Mouth/teeth dental problems: Dentures	1.2	2.1	5.5	-2.1	-2.0	0.8	-2.3	-1.3	-1.2	-1.2	-1.4	-2.0	-0.9	1.0	0.3	0.7
Asthma	2.1	4.1	8.0	-2.7	-2.7	1.6	-1.3	-2.2	-2.0	-2.2	-2.3	-2.8	-2.0	1.4	0.1	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.4	-0.8	-0.9	0.7	-1.5	-0.1	-0.0	-0.1	-0.5	-1.2	-0.6	1.0	-0.4	0.5
Medication: Cholesterol lowering	1.4	2.1	7.9	1.3	0.6	-2.4	-0.2	1.2	1.0	1.0	0.9	0.9	0.8	-2.4	-2.8	0.7
Depression (self-reported)	1.2	1.5	6.9	-0.4	-1.0	2.6	-1.9	-1.1	-1.2	-1.1	-1.0	-0.8	-1.1	0.3	-0.8	0.3
Medication: Lansoprazole	3.8	4.3	7.0	-2.6	-1.6	1.1	-1.5	-2.4	-2.2	-2.3	-2.3	-2.6	-2.2	1.6	1.9	-1.8
Prospective memory result	2.2	2.7	5.6	-2.0	-1.8	-0.2	-1.1	-1.3	-1.9	-2.0	-2.0	-2.4	-2.1	1.5	0.7	-0.7
Lung cancer (father)	0.3	0.3	1.1	-0.5	0.7	-0.5	-0.8	-0.1	0.2	0.1	0.1	0.2	-0.6	-0.3	0.8	-1.0
Illnesses of mother	0.3	0.4	1.6	-0.5	-0.7	1.0	-0.8	-0.3	-0.6	-0.6	-0.5	-0.2	-0.5	1.2	-0.2	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	6.9	24.0	3.2	4.9	-1.3	2.6	2.0	2.4	2.3	2.8	4.3	2.1	0.3	0.2	-1.4
Pulse wave Arterial Stiffness index	1.2	1.3	2.7	1.0	0.5	-0.8	0.3	1.4	1.6	1.4	1.2	0.8	1.3	-1.5	-1.6	0.2
Impedance of arm (left)	0.3	1.5	3.3	-1.2	-0.6	1.8	0.3	-1.0	-1.3	-1.1	-0.9	-1.2	-1.2	1.7	1.8	0.9
Arm fat mass (right)	1.7	7.0	11.1	-3.1	-2.9	0.5	-2.4	-2.9	-2.7	-2.9	-3.0	-3.3	-2.7	3.2	1.2	-1.8
Trunk predicted mass	1.2	6.8	15.0	3.1	3.6	-3.9	1.4	2.9	2.8	2.6	2.5	3.0	2.3	-1.8	-1.6	0.0
Standing height	2.6	25.6	46.4	6.1	6.8	-5.5	3.9	5.9	5.5	5.4	5.5	6.0	4.8	-3.4	-1.9	2.4
Length of working week for main job	1.9	2.1	6.1	-1.5	-0.9	1.3	-1.4	-1.4	-1.1	-1.2	-1.2	-1.7	-1.2	1.3	2.5	-1.4
Exposure to tobacco smoke at home	0.3	0.3	1.1	0.6	-0.1	-0.7	-0.2	0.6	1.1	0.9	0.4	0.4	0.6	-0.3	-0.2	-0.1
Breastfed as a baby	6.2	7.6	11.1	3.3	3.0	-2.8	1.3	3.3	2.9	2.9	2.9	2.4	2.7	-1.7	-2.8	3.2
Tense / ‘highly strung’	1.1	1.9	5.4	-1.5	-1.2	2.2	-2.3	-1.6	-1.4	-1.4	-1.4	-0.8	-0.6	-0.6	0.4	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	4.3	-1.0	-1.4	2.1	-1.0	-0.2	-0.2	-0.1	-0.5	-1.0	0.1	1.5	1.1	0.8
Hair/balding pattern: Pattern 4	0.1	0.2	0.8	-0.9	-0.8	-0.6	-0.3	0.1	0.0	-0.1	0.0	-0.2	0.4	-0.1	0.6	-0.1
Birth weight of first child	0.2	0.3	2.6	0.1	-0.4	0.1	-0.1	0.2	0.1	0.1	0.1	0.4	-0.1	-0.3	-1.6	0.7
Peak expiratory flow (PEF)	0.3	0.7	3.7	0.9	1.9	-1.2	-0.5	0.7	0.4	0.4	0.7	1.3	0.2	-0.6	-0.3	-0.1
Pulse wave reflection index	1.1	1.3	5.5	0.7	0.2	-2.3	1.9	1.3	1.2	1.2	1.1	0.5	1.0	-0.4	-0.7	0.0
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.1	-0.9	-1.4	1.0	0.6	-0.9	-1.1	-1.0	-1.1	-1.7	-1.1	1.5	1.3	-1.2
Loud music exposure frequency	0.7	0.7	5.0	0.7	-0.3	-2.2	-1.2	0.2	0.1	-0.1	-0.2	-0.2	-0.5	0.9	0.4	-1.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	4.1	1.8	1.8	-0.9	0.5	1.2	0.6	0.7	1.2	1.6	0.2	-0.8	-2.0	0.1
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	5.8	-0.8	-1.1	1.9	-1.6	-2.3	-2.4	-2.3	-2.1	-2.0	-2.1	0.7	1.4	-1.0
Blood clot in the leg (DVT)	3.1	4.0	7.3	-2.2	-2.7	1.2	-0.5	-1.8	-1.8	-1.8	-2.3	-2.2	-1.9	2.7	2.1	-1.4
Medication: Paracetamol	0.8	1.3	2.6	-0.9	-1.3	1.6	-1.5	-0.7	-0.7	-0.8	-0.9	-1.4	-0.8	1.3	1.2	-0.8
Headache pain in last month	0.2	0.4	3.3	0.7	0.2	0.1	0.1	0.4	-0.3	-0.3	-0.2	-0.7	-0.0	0.1	0.7	1.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	2.8	0.3	0.9	0.7	1.7	0.5	0.4	0.3	0.7	0.4	0.8	0.1	0.2	1.2
Glaucoma (self-reported)	15.3	18.0	36.0	-5.2	-6.0	1.5	-2.9	-4.4	-5.2	-5.2	-5.1	-5.7	-5.2	1.0	0.0	0.2
Gout (self-reported)	0.9	1.3	2.6	-0.8	-1.2	-0.6	-1.3	-1.4	-1.5	-1.6	-1.5	-1.0	-1.1	0.4	0.8	-0.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.6	-1.5	-1.6	0.1	-1.6	-0.8	-0.8	-1.0	-1.1	-1.0	-1.1	-1.2	-1.4	0.1
Medication: Amlodipine	1.1	1.5	9.5	-1.1	-1.0	0.1	-3.1	-1.0	-1.0	-1.1	-1.3	-0.7	-1.3	0.4	0.5	-0.9
Medication: Ventolin 100micrograms inhaler	3.4	4.4	11.2	-2.3	-2.2	3.4	-1.8	-2.1	-1.8	-1.9	-2.2	-3.1	-1.8	1.4	0.5	-0.4
Birth weight	0.4	0.8	2.7	1.3	1.1	-0.2	0.4	0.9	0.9	0.8	0.7	1.6	0.5	1.2	0.3	-0.3
Chronic bronchitis/emphysema (mother)	1.7	2.0	3.7	-1.5	-0.8	0.4	-1.8	-1.3	-1.1	-1.4	-1.8	-1.9	-1.8	1.1	1.1	-1.4
High blood pressure (siblings)	0.3	0.5	1.9	0.6	-0.2	-1.4	-1.2	-0.4	-0.2	-0.3	-0.4	-0.9	-0.1	-0.9	0.4	0.1
Forced vital capacity (FVC), Best measure	1.1	4.2	14.7	2.2	3.8	-0.8	2.4	1.3	1.7	1.6	1.8	3.4	1.3	1.1	1.3	-1.4
Body fat percentage	2.3	9.1	14.2	-3.6	-3.7	1.5	-2.8	-3.2	-3.1	-3.2	-3.4	-3.8	-2.9	3.2	1.6	-1.9
Leg fat percentage (right)	1.7	6.1	10.0	-2.7	-3.2	0.7	-3.0	-2.6	-2.6	-2.7	-2.8	-3.0	-2.5	2.0	0.3	-2.0
Arm fat-free mass (right)	0.7	3.7	6.9	2.4	2.6	-2.6	1.6	2.2	2.1	1.8	1.9	2.0	1.9	-1.3	-1.2	0.0
Exposure to tobacco smoke outside home	0.7	0.9	5.1	-1.2	-0.1	0.6	0.0	-1.3	-0.4	-0.5	-1.1	-0.1	-0.7	0.6	1.1	-2.3
Comparative body size at age 10	0.2	0.5	1.2	-0.7	-0.8	-0.8	0.5	-0.3	-0.9	-0.8	0.1	-0.4	-0.6	-0.6	-0.9	1.1
Number of full brothers	0.1	0.1	0.3	0.1	0.0	-0.0	-0.4	0.2	0.4	0.3	0.3	0.4	0.6	-0.6	-0.4	-0.3
Worry too long after embarrassment	2.1	3.5	8.3	-1.9	-2.9	1.8	-2.0	-1.9	-1.7	-1.8	-2.1	-2.3	-1.5	2.0	0.5	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.6	-0.7	-1.2	1.0	-1.1	-0.3	-0.3	-0.2	-0.6	-0.7	-0.4	1.6	0.3	0.5
Wheeze or whistling in the chest in last year	2.4	4.3	11.2	-2.7	-2.8	1.0	-1.8	-1.6	-2.0	-2.1	-2.6	-3.3	-2.2	1.3	0.8	-0.6
Number of children fathered	0.6	0.7	3.4	1.1	0.5	-1.8	0.8	1.0	0.6	0.6	0.7	0.7	0.8	-0.7	0.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.9	-0.4	-0.8	0.4	0.9	0.1	-0.3	-0.3	-0.2	-0.4	0.0	0.5	0.0	0.3
Age at first live birth	4.6	8.1	12.2	3.1	2.5	-1.4	1.7	2.8	3.1	3.0	3.2	3.5	3.4	-3.2	-3.1	2.1
Pulse wave peak to peak time	0.7	0.9	3.2	-0.7	-0.1	0.5	0.2	-0.9	-1.2	-1.0	-0.9	-0.5	-1.0	1.3	1.8	0.0
Health satisfaction	1.0	1.4	4.4	-1.4	-1.8	0.8	-0.8	-1.2	-1.0	-1.0	-1.2	-2.1	-0.6	0.9	0.1	0.9
Shortness of breath walking on level ground	5.0	6.0	14.9	-2.4	-3.4	1.4	-3.9	-2.5	-2.4	-2.5	-2.6	-3.7	-2.2	-0.0	0.0	-0.5
Qualifications: College or University degree	0.8	2.6	5.5	1.7	2.1	-0.4	0.7	1.8	1.8	1.7	1.7	2.3	1.2	-2.2	-1.0	0.6
Eye problems/disorders: None of the above	8.6	9.9	17.7	3.2	4.2	-3.0	2.6	3.6	3.6	4.0	4.0	3.8	3.1	-1.6	-0.7	1.0
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.9	0.6	0.0	-0.5	-0.6	0.7	0.4	0.4	0.5	-0.0	0.1	-0.2	-0.8	0.9
Emphysema/chronic bronchitis	1.9	2.2	4.7	-1.4	-1.8	-0.6	-0.7	-1.4	-1.6	-1.6	-1.9	-2.2	-1.5	1.2	0.7	-1.6
Medication for pain relief, constipation, heartburn	0.6	1.1	2.7	0.7	1.5	-1.5	1.2	0.9	0.5	0.6	0.9	1.6	0.3	-1.2	-0.3	1.2
Neck or shoulder pain in last month	1.1	1.6	5.6	-0.7	-0.9	0.9	-2.2	-1.0	-0.7	-0.8	-1.2	-1.3	-0.7	2.4	1.4	-0.9
Medication: Blood pressure	0.6	1.0	3.7	-1.3	-1.1	-0.0	-1.9	-0.9	-0.7	-0.6	-0.9	-0.7	-1.0	0.7	1.2	-1.0
Angina (self-reported)	2.8	3.6	9.8	1.2	1.8	-3.1	2.1	1.3	1.9	2.0	2.0	2.3	2.5	-2.0	-0.1	0.1
Migraine (self-reported)	3.0	3.7	10.4	-1.9	-0.8	1.9	-0.2	-2.2	-1.8	-1.8	-1.8	-2.4	-1.2	2.5	3.2	1.3
Medication: Ibuprofen	0.4	0.4	1.9	-0.2	-0.3	0.9	-1.0	0.0	0.1	0.1	0.0	-0.5	-0.0	0.6	-1.1	1.4
Medication: Allopurinol	0.6	0.9	2.6	-0.6	-1.0	-1.0	-1.6	-0.7	-1.2	-1.1	-1.0	-0.7	-0.8	-0.7	-0.6	0.3
Medication: Omeprazole	0.4	0.4	2.0	0.4	-0.3	-0.1	0.2	1.0	0.7	0.8	0.6	-0.5	0.7	0.2	-1.4	-0.1
Medication: Seretide 50 evohaler	0.3	0.3	1.1	-0.6	-0.5	0.2	0.1	-0.6	-0.4	-0.8	-0.7	-0.7	-0.3	0.4	-0.1	-1.0
Mean time to correctly identify matches	0.2	0.3	2.1	-0.8	-0.0	0.7	1.4	-0.8	-0.4	-0.3	-0.2	-0.1	0.2	0.3	0.6	0.1
Heart disease (mother)	3.7	4.5	8.2	1.9	2.0	-2.7	1.2	2.3	2.3	2.5	2.3	2.3	2.0	-2.9	-1.5	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.9	7.0	1.0	0.4	-2.3	-1.7	2.3	1.7	1.5	1.5	0.9	1.4	-1.8	-2.6	1.9
Whole body fat mass	1.1	4.5	7.8	-2.5	-2.5	0.5	-1.9	-2.2	-2.1	-2.2	-2.4	-2.8	-2.1	2.5	1.2	-1.5
Leg fat mass (right)	0.9	3.7	6.2	-2.1	-2.1	0.1	-2.2	-1.9	-1.9	-2.0	-2.2	-2.5	-2.0	1.9	0.5	-1.9
Arm predicted mass (right)	0.8	4.2	8.2	2.6	2.9	-2.5	1.4	2.3	2.3	2.0	2.0	2.3	2.0	-1.5	-1.4	-0.2
Pulse rate, automated reading	0.1	0.4	2.4	0.2	-0.3	1.5	-0.9	-0.2	0.4	0.3	0.3	-0.3	0.6	-0.8	-0.8	0.3
Alcohol intake frequency.	0.5	1.1	3.1	-0.3	-1.5	0.4	0.4	-1.1	-1.3	-1.3	-1.2	-1.8	-0.9	1.0	-0.2	0.7
Comparative height size at age 10	0.7	4.0	10.6	1.9	2.6	-3.2	2.4	1.8	1.9	1.9	1.8	2.9	1.5	-0.7	0.6	0.1
Number of full sisters	1.3	1.6	4.8	-1.5	-1.0	2.2	-0.7	-1.2	-1.0	-1.0	-1.0	-1.3	-0.7	2.2	0.9	-0.5
Suffer from ‘nerves’	0.3	0.5	2.1	-0.4	-0.3	0.6	-0.6	-0.8	-0.9	-0.9	-0.8	-1.4	-0.6	-0.5	-0.1	0.4
Overall health rating	0.9	1.8	5.4	-0.9	-1.4	1.2	-0.4	-1.8	-1.4	-1.6	-1.8	-2.3	-1.2	1.1	0.7	-0.4
Chest pain or discomfort	0.1	0.2	1.2	-0.0	-0.3	-0.7	-1.1	0.2	-0.1	-0.2	-0.0	0.1	0.1	-0.7	-0.4	-0.2
Had major operations	1.7	2.0	3.7	-1.1	-1.5	-0.2	-1.9	-1.7	-1.2	-1.4	-1.6	-1.8	-1.2	1.3	1.8	-1.0
Age at last live birth	8.6	12.4	21.8	3.9	3.5	-3.0	1.2	3.6	3.7	3.5	3.8	4.1	4.0	-4.7	-3.7	1.7
Family relationship satisfaction	2.3	2.9	5.9	1.5	1.1	-1.0	1.3	2.2	1.8	1.8	1.7	1.3	1.9	-2.0	-1.3	2.4
Leg pain on walking	2.7	3.4	8.0	2.8	1.9	-2.1	1.1	1.9	2.2	2.1	2.0	1.6	2.0	-1.7	-0.6	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.7	0.3	0.3	-1.3	1.0	0.2	0.4	0.2	0.5	-0.2	0.2	-0.2	-0.8	-1.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	0.8	1.0	-0.3	0.1	0.8	0.7	0.6	0.5	0.7	0.4	-0.6	-1.0	0.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.7	-1.0	-0.2	1.6	0.9	-1.0	-0.8	-0.8	-0.6	-1.6	-1.2	-0.3	-0.2	-1.0
Medication: Aspirin	0.5	0.7	2.8	0.7	-0.2	-1.7	-0.5	0.1	0.5	0.6	0.3	0.8	0.8	-0.9	-0.5	-1.3
Supplements: Vitamin C	2.3	2.7	4.7	-1.4	-1.1	2.2	-0.8	-1.9	-1.7	-1.7	-2.1	-2.1	-1.8	1.6	1.3	-0.5
Knee pain experienced in last month	0.3	0.5	2.6	1.6	1.0	-1.0	-0.7	-0.1	-0.1	-0.3	-0.4	0.2	0.5	-0.9	0.0	0.5
Hypertension (Self-reported)	1.5	4.0	7.2	-2.2	-2.7	0.7	-2.1	-2.1	-2.1	-2.2	-2.6	-2.5	-2.4	0.6	0.9	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.4	-1.3	-1.2	1.9	0.1	-0.8	-0.8	-1.0	-0.8	-1.6	-0.6	1.4	-0.1	0.8
Illnesses of father: Heart disease	3.4	4.7	13.9	2.3	2.0	-3.7	1.4	2.3	1.7	1.7	1.8	2.3	1.7	-2.9	-2.2	0.7
Illnesses of siblings: Diabetes	1.1	1.3	2.9	-1.4	-1.4	1.0	-0.8	-1.7	-1.2	-1.3	-1.1	-1.6	-0.8	-0.2	1.0	0.2
Smoking status: Previous	0.4	0.7	2.4	-0.0	-0.3	-1.6	0.0	0.9	0.4	0.5	0.5	-0.3	0.2	-1.6	-1.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	18.3	3.3	4.3	-2.1	1.8	2.0	2.0	2.0	2.2	2.6	1.9	-0.4	0.1	0.7
Whole body fat-free mass	0.5	3.0	9.2	2.0	2.5	-3.0	1.0	1.9	1.8	1.6	1.6	1.8	1.5	-0.8	-0.9	-0.2
Leg fat-free mass (right)	0.1	0.3	3.1	0.2	0.7	-1.8	0.4	0.2	0.1	-0.1	-0.0	-0.1	0.0	0.5	0.2	-0.6
Arm fat percentage (left)	3.8	15.0	24.4	-4.7	-4.5	2.2	-3.2	-4.2	-4.1	-4.2	-4.4	-4.9	-3.9	4.1	2.1	-2.1
Average weekly red wine intake	0.1	0.2	1.0	0.4	0.3	-0.2	-0.3	0.6	0.2	0.3	0.2	0.9	-0.0	0.1	-1.0	-0.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.9	-1.7	-1.1	-1.0	-0.0	-1.1	-1.0	-1.2	-1.0	-0.4	-1.0	1.5	0.3	-0.2
Mood swings	1.9	3.4	5.6	-2.3	-2.4	2.1	-0.3	-2.0	-2.0	-2.2	-2.2	-1.9	-1.8	1.2	0.7	-1.6
Loneliness, isolation	0.5	0.8	2.6	-0.9	-1.4	1.5	-0.3	-0.6	-0.1	-0.2	-0.6	-0.7	0.2	0.7	1.6	-0.7
Long-standing illness, disability or infirmity	0.9	1.4	3.5	-1.0	-1.9	1.5	-1.3	-1.4	-1.0	-1.2	-1.4	-1.4	-1.0	0.2	-0.3	-0.7
Ever had bowel cancer screening	1.4	1.6	5.3	-2.3	-2.2	0.8	-0.3	-0.8	-1.1	-1.1	-1.4	-1.7	-1.1	0.8	0.9	0.2
Diabetes diagnosed by doctor	0.3	0.5	2.7	0.3	-0.6	-0.3	-1.5	0.4	0.4	0.3	0.3	-0.0	0.1	-0.6	-1.6	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.4	-0.7	-1.0	-0.7	-1.2	-0.2	0.2	-0.1	-0.2	0.2	0.1	0.7	-0.2	-1.2
Friendships satisfaction	1.2	1.5	7.8	1.5	-0.2	0.7	0.3	1.0	0.6	0.7	0.8	-0.0	0.7	-1.7	-1.7	2.8
Qualifications: nursing, teaching	0.4	0.7	2.6	0.3	0.6	-0.2	-0.5	0.3	0.2	0.3	0.7	0.7	-0.0	-1.6	-1.4	-1.4
Commuting to job workplace: Walk	1.0	1.0	1.6	-0.8	-1.1	0.7	-1.0	-0.9	-1.1	-1.2	-1.1	-1.1	-1.3	0.9	1.2	-0.4
Eye problems/disorders: Cataract	0.5	0.6	2.3	-0.2	-1.1	1.5	-1.2	-0.5	-0.6	-1.0	-0.9	-0.7	-0.5	-0.2	-0.3	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	2.4	0.3	0.0	0.7	-0.8	0.2	0.3	0.2	0.0	-0.1	0.2	1.0	0.5	1.6
Medication for cholesterol	5.6	8.4	14.7	2.7	2.9	-1.7	3.0	3.5	3.2	3.3	3.7	3.8	3.2	-1.4	-1.9	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.3	0.1	-0.1	0.2	-0.2	0.3	0.2	-0.1	-0.2	0.4	0.3	0.6	0.0
Back pain experienced in last month	1.7	2.4	8.7	2.4	1.2	-2.9	-0.7	1.5	1.4	1.5	1.6	1.4	1.7	-0.7	-1.0	0.4
Mineral and other dietary supplements	0.6	0.8	2.6	-0.2	-0.7	1.5	1.4	-0.7	-0.4	-0.4	-0.7	0.1	-0.5	1.0	0.4	-1.6
Breast cancer (self-reported)	0.6	0.7	2.4	-0.1	-1.4	-0.4	-0.1	-0.4	-0.9	-0.8	-0.6	-1.6	-0.3	1.0	1.2	0.2
Asthma (self-reported)	2.0	4.0	8.8	-2.7	-2.8	1.4	-1.4	-2.1	-2.0	-2.2	-2.3	-3.0	-2.0	1.1	0.1	-1.0
Osteoporosis (self-reported)	0.4	0.5	1.9	-0.7	0.1	0.6	0.8	0.2	0.5	0.7	0.1	0.4	0.3	-1.2	-1.4	-0.9
Osteoarthritis (self-reported)	0.4	0.6	5.2	0.2	0.3	0.1	-2.3	-0.4	0.1	-0.1	-0.3	-0.2	-0.0	1.0	0.2	-0.7
Medication: Aspirin	0.6	0.7	3.6	0.7	-0.0	-1.9	-0.3	0.2	0.6	0.7	0.3	1.0	1.0	-0.9	-0.8	-1.1
Medication: Gliclazide	0.4	0.4	1.7	-0.2	-0.3	-0.1	-0.6	0.7	0.3	0.5	0.6	-0.2	0.6	-1.3	-0.5	1.3
Illnesses of father: None of the above (group 1)	1.7	2.1	8.1	-1.7	-1.5	2.8	0.1	-1.8	-1.4	-1.5	-1.4	-1.4	-1.3	1.1	0.5	0.1
Smoking status: Current	2.1	3.3	5.5	2.2	2.3	-1.5	1.1	2.1	2.3	2.1	1.9	2.1	2.4	-0.6	-0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	2.0	0.1	1.1	0.2	0.6	-0.4	0.3	0.2	0.7	1.2	0.3	0.3	0.0	-1.4
Whole body water mass	0.5	2.7	8.9	1.9	2.4	-3.0	0.8	1.8	1.7	1.4	1.4	1.7	1.3	-0.9	-0.9	-0.3
Leg predicted mass (right)	0.1	0.4	3.2	0.2	0.7	-1.8	0.3	0.3	0.2	-0.0	0.0	-0.0	0.1	0.5	0.2	-0.6
Arm fat mass (left)	1.6	6.7	11.0	-3.0	-2.9	0.8	-2.4	-2.8	-2.6	-2.8	-3.0	-3.3	-2.6	3.1	1.1	-1.8
Number of self-reported non-cancer illnesses	0.8	1.4	5.2	-1.2	-2.3	0.3	-1.5	-0.5	-0.6	-0.8	-1.2	-2.2	-1.1	-0.1	-0.4	0.1
Average weekly champagne plus white wine intake	0.2	0.3	0.8	0.1	-0.1	-0.2	-0.5	-0.4	-0.7	-0.6	-0.2	-0.6	-0.3	-0.7	-0.8	0.9
Miserableness	3.1	5.4	12.2	-2.5	-3.5	2.0	-0.7	-2.4	-2.6	-2.9	-2.7	-3.2	-2.1	1.5	0.6	-1.2
Guilty feelings	1.1	1.7	2.7	-1.5	-1.6	1.2	-0.4	-1.3	-1.3	-1.2	-1.6	-1.3	-1.2	1.4	1.6	-0.4
Wears glasses or contact lenses	0.4	0.4	1.2	-0.1	-0.8	-1.1	-1.1	0.4	-0.1	-0.1	-0.2	-0.3	-0.4	-1.1	-0.9	-0.1
Ever taken oral contraceptive pill	1.0	1.1	1.9	0.7	1.2	-1.3	-0.4	1.0	1.3	1.2	1.3	1.4	1.1	-1.3	0.3	-0.7
Hearing aid user	1.2	1.3	2.9	-1.7	-1.4	0.0	-0.9	-1.5	-0.8	-1.0	-1.1	-1.3	-1.0	1.0	0.8	-1.5
Mother’s age at death	1.0	1.2	8.0	0.3	-0.7	-0.9	0.5	0.3	-0.5	-0.4	-0.2	-0.4	-0.3	-0.8	-2.8	2.2
Financial situation satisfaction	0.4	0.5	1.5	1.2	0.9	0.5	0.5	0.7	0.9	0.8	0.9	0.0	0.8	-0.1	0.0	0.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	6.1	-2.1	-1.9	0.1	-1.0	-0.2	-0.0	-0.1	-1.0	-1.2	-0.6	2.5	0.5	-0.2
Commuting to job workplace: Public transport	1.7	2.1	4.7	1.1	1.3	0.2	1.8	1.6	1.5	1.7	2.2	1.5	1.5	-0.1	-1.3	1.5
Eye problems/disorders: Glaucoma	18.9	22.4	41.7	-6.2	-6.5	2.1	-3.6	-5.2	-5.7	-5.7	-5.6	-6.2	-5.5	1.6	0.3	-0.4
Medication: Blood pressure	2.7	5.1	8.1	-2.1	-2.1	1.2	-1.6	-2.8	-2.6	-2.6	-2.8	-2.7	-2.4	1.0	2.3	-2.1
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.9	-0.4	-0.7	-0.4	-0.7	-1.2	-1.2	-1.3	-1.4	-0.8	-0.5	-0.2	-0.3	0.9
Supplements: Fish oil (including cod liver oil)	0.9	1.2	5.9	0.8	1.3	-1.0	-1.4	0.7	0.4	0.4	0.6	0.1	0.3	-2.4	-1.3	1.1
High cholesterol (Self-reported)	0.2	0.4	2.3	-0.2	-0.5	-0.8	-0.9	0.4	0.5	0.4	0.3	0.3	-0.3	-0.4	-1.5	-0.6
Medication: Bendroflumethiazide	4.3	6.5	11.9	-2.2	-1.4	0.9	-2.4	-2.9	-3.0	-3.0	-3.2	-2.7	-3.0	1.4	3.5	-2.2
Medication: Paracetamol	1.0	1.6	4.4	-0.9	-1.3	2.1	-1.3	-1.2	-0.9	-1.0	-0.9	-1.3	-0.8	1.4	1.8	-0.5
Medication: Lisinopril	0.1	0.1	0.7	-0.4	-0.1	0.4	-0.8	-0.2	0.2	0.3	-0.0	0.1	-0.1	-0.7	-0.5	-0.0
Medication: Atorvastatin	0.3	0.3	1.2	-0.1	0.0	-0.9	-0.6	0.3	0.5	0.5	0.3	0.4	0.0	-0.6	-0.8	-1.1
Illnesses of father: High blood pressure	0.8	1.0	2.6	-0.5	-0.3	-0.5	-1.6	-0.5	-1.4	-1.2	-1.0	-1.2	-1.0	0.3	0.2	1.6
Alcohol drinker status: Never	0.5	0.6	1.3	-0.0	-0.8	0.5	-0.0	-1.2	-1.2	-1.1	-0.8	-1.0	-0.6	0.3	0.2	-0.4
Ever smoked	1.1	1.9	4.8	1.4	1.1	-2.2	0.5	2.0	1.4	1.5	1.4	0.5	0.9	-1.6	-1.6	0.6
Basal metabolic rate	0.3	1.5	7.2	1.3	1.8	-2.7	0.4	1.1	1.1	0.9	0.8	1.1	0.8	-0.3	-0.6	-0.7
Leg fat percentage (left)	1.9	6.8	11.2	-2.9	-3.4	1.1	-3.1	-3.0	-2.8	-2.8	-3.0	-3.2	-2.5	1.9	0.8	-2.2
Arm fat-free mass (left)	0.7	3.4	9.0	2.2	2.4	-3.0	0.6	1.9	2.0	1.8	1.6	2.0	1.6	-1.4	-1.5	-0.5
Number of operations (self-reported)	0.3	0.4	2.0	0.3	-0.1	-1.4	-0.5	0.3	0.7	0.6	0.5	0.1	1.1	0.3	0.9	-0.0
Average weekly beer plus cider intake	0.5	0.8	3.3	1.3	1.2	1.8	-0.6	-0.3	0.2	0.1	-0.2	-0.1	-0.1	0.3	1.3	-1.2
Irritability	0.6	1.0	4.5	-0.8	-1.3	1.1	-0.2	-0.7	-1.0	-1.0	-0.6	-0.4	-0.4	-2.1	-0.1	-1.2
Risk taking	1.0	1.5	4.2	-0.9	-1.4	0.8	-1.4	-0.8	-1.0	-1.0	-1.3	-0.8	-1.1	1.7	0.4	-2.0
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.3	-1.2	-1.5	-0.2	-1.3	-1.1	-1.2	-1.1	-1.4	-1.5	-1.5	0.3	0.8	-1.2
Fractured/broken bones in last 5 years	1.1	1.4	5.8	-0.7	-1.5	0.2	-1.4	-0.7	-0.9	-1.1	-1.3	-2.4	-1.3	0.3	0.8	-1.0
Age started oral contraceptive pill	1.6	2.0	8.5	0.8	1.0	-1.1	1.2	1.3	1.4	1.4	1.3	1.0	1.1	-2.9	-1.8	0.3
Diastolic blood pressure, automated reading	0.1	0.5	2.9	0.6	-0.2	-0.8	-0.9	-0.2	-0.3	-0.6	-0.3	-0.2	-0.0	-0.7	0.3	-1.7
Ever depressed for a whole week	1.1	1.4	5.8	-1.3	-1.6	0.8	-0.6	-0.5	-0.6	-0.6	-0.6	-1.5	-0.3	2.4	1.7	0.3
Unable to work because of sickness or disability	0.7	0.9	3.2	-1.0	-1.1	0.1	-1.8	-1.1	-0.9	-1.0	-1.3	-0.3	-0.5	0.8	0.2	-0.7
Commuting to job workplace: Cycle	0.7	0.8	5.3	1.1	0.9	-0.2	-0.6	0.8	0.2	0.2	0.4	1.0	0.2	-2.3	-0.9	0.2
Myopia	0.2	0.3	1.3	-0.5	-1.0	-0.4	0.5	0.3	-0.1	-0.2	0.1	-0.4	-0.2	-1.1	-0.6	0.6
Vascular/heart problems diagnosed by doctor	1.0	2.6	4.4	1.6	2.0	-0.7	1.3	1.8	1.6	1.7	2.1	2.0	1.9	-0.4	-1.0	1.8
Cholesterol lowering medication	0.6	0.9	4.4	-0.5	-0.0	-0.7	-1.6	-1.0	-0.6	-0.7	-0.7	-0.7	-0.9	-0.9	-0.3	-2.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.0	0.8	-0.0	0.6	-0.1	0.5	0.2	0.3	0.1	-0.6	0.5	0.1	-1.0	-0.2
Pain experienced in last month	1.5	2.6	7.3	0.6	0.9	0.3	2.7	1.8	1.6	1.7	1.9	1.8	0.8	-2.2	-1.9	0.8
Supplements: Calcium	1.7	1.9	5.3	-1.3	-1.1	1.1	-1.9	-1.2	-1.0	-1.0	-1.3	-2.3	-1.3	1.4	0.8	-1.2
Basal cell carcinoma (self-reported)	0.3	0.4	1.9	0.1	0.6	0.3	0.0	0.3	0.8	0.8	0.2	0.1	0.6	1.4	0.7	0.1
Heart attack/myocardial infarction (self-reported)	1.8	2.4	5.9	2.4	2.0	-1.3	0.5	1.6	1.7	1.6	1.4	2.2	1.4	-1.3	-0.5	-0.6
Deep venous thrombosis (DVT) (self-reported)	3.1	3.9	7.7	-2.3	-2.8	1.4	-0.7	-1.7	-1.7	-1.8	-2.3	-2.3	-1.9	2.6	2.0	-1.2
Heart disease (siblings)	0.4	0.6	2.3	-0.1	0.4	0.1	0.2	0.6	1.0	0.9	0.8	0.8	1.0	-1.5	-0.6	0.2
Alcohol drinker status: Previous	0.3	0.4	1.9	-0.5	-0.6	-0.1	-0.5	-0.3	-0.2	-0.2	-0.2	-0.5	-0.3	1.4	1.1	0.3
Pack years of smoking	0.9	1.4	4.4	-1.5	-1.8	0.8	-2.1	-0.5	-0.5	-0.6	-0.8	-1.1	-1.1	1.4	1.1	-0.6
Impedance of whole body	0.1	0.5	1.8	0.3	0.5	1.4	0.9	0.2	0.2	0.4	0.4	0.4	0.3	0.4	1.2	1.0
Leg fat mass (left)	1.0	4.0	6.4	-2.2	-2.2	0.4	-2.2	-2.1	-2.0	-2.1	-2.3	-2.5	-2.0	1.9	0.7	-2.0
Arm predicted mass (left)	0.5	2.8	9.4	2.0	2.1	-3.1	0.4	1.7	1.8	1.5	1.4	1.7	1.4	-1.1	-1.2	-0.4