Best TWAS P=3.03e-10 · Best GWAS P=8.87e-09 conditioned to 1.53e-64
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MXD4 | 0.08 | 0.10 | lasso | 2 | 0.10 | 1.8e-12 | 5.6 | 5.3 | 1.1e-07 | -0.05 | 0.03 | 0.97 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | POLN | 0.05 | 0.05 | lasso | 13 | 0.04 | 8.6e-06 | 5.7 | -5.5 | 3.9e-08 | 0.08 | 0.06 | 0.93 | TRUE |
| 3 | GTEx | Adipose Subcutaneous | FGFR3 | 0.08 | 0.01 | lasso | 6 | 0.03 | 9.3e-04 | 4.0 | 6.3 | 3.0e-10 | -0.07 | 0.30 | 0.17 | TRUE |
| 4 | GTEx | Thyroid | FAM193A | 0.11 | 0.01 | lasso | 3 | 0.00 | 2.2e-01 | -4.4 | -5.6 | 2.1e-08 | 0.74 | 0.06 | 0.65 | TRUE |
| 5 | METSIM | Adipose | TMEM129 | 0.11 | 0.09 | lasso | 8 | 0.09 | 3.3e-13 | -4.8 | 5.2 | 2.3e-07 | -0.09 | 0.24 | 0.75 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | POLN | 0.02 | 0.00 | blup | 87 | 0.01 | 1.9e-02 | 5.2 | 5.3 | 1.2e-07 | -0.06 | 0.03 | 0.73 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | DOK7 | 0.22 | 0.10 | lasso | 3 | 0.14 | 9.2e-14 | 5.7 | 5.3 | 1.1e-07 | -0.04 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | RGS12 | 0.08 | 0.01 | blup | 108 | 0.01 | 2.4e-02 | 5.3 | 5.8 | 6.4e-09 | -0.01 | 0.01 | 0.55 | TRUE |