Best TWAS P=1.5e-32 · Best GWAS P=7.63e-30 conditioned to 4.85e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | GUCY1B3 | 0.18 | 0.09 | enet | 25 | 0.08 | 3.4e-05 | 9.2 | -8.1 | 4.9e-16 | -0.63 | 0.02 | 0.95 | FALSE |
| 2 | GTEx | Artery Aorta | GUCY1A3 | 0.29 | 0.12 | lasso | 6 | 0.19 | 1.7e-10 | 10.0 | -11.8 | 4.9e-32 | -0.69 | 0.40 | 0.59 | FALSE |
| 3 | GTEx | Artery Aorta | RP11-588K22.2 | 0.22 | 0.11 | lasso | 11 | 0.11 | 1.6e-06 | 10.0 | -11.9 | 1.5e-32 | -0.69 | 0.18 | 0.76 | TRUE |
| 4 | METSIM | Adipose | CTSO | 0.06 | 0.03 | enet | 8 | 0.03 | 5.3e-06 | 4.2 | -5.3 | 9.0e-08 | 0.04 | 0.99 | 0.00 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | RP11-588K22.2 | 0.05 | 0.03 | lasso | 4 | 0.02 | 5.5e-04 | 5.7 | -5.3 | 1.2e-07 | -0.04 | 0.32 | 0.03 | FALSE |
| 6 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | GUCY1A3 | 0.18 | 0.02 | blup | 79 | 0.09 | 3.5e-04 | 4.8 | -6.5 | 9.7e-11 | 0.00 | 0.02 | 0.19 | TRUE |