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chr15:90,718,541-92,135,418

Best TWAS P=1.71e-13 · Best GWAS P=5.38e-11 conditioned to 0.837

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FURIN	0.12	0.14	lasso	2	0.13	1.2e-15	6.0	-6.0	2.5e-09	0.82	0.05	0.95	FALSE
2	GTEx	Adipose Visceral Omentum	FES	0.21	0.09	lasso	5	0.05	1.3e-03	-5.8	5.9	2.7e-09	-0.68	0.19	0.62	FALSE
3	GTEx	Artery Tibial	FES	0.16	0.04	lasso	5	0.05	4.8e-05	-5.5	5.2	2.4e-07	-0.71	0.19	0.79	FALSE
4	GTEx	Cells Transformed fibroblasts	FES	0.28	0.17	enet	21	0.20	2.8e-15	-5.8	6.4	1.4e-10	-0.87	0.03	0.97	FALSE
5	GTEx	Lung	FES	0.24	0.07	lasso	6	0.05	5.1e-05	-5.5	5.6	1.7e-08	-0.77	0.07	0.92	FALSE
6	GTEx	Thyroid	FES	0.33	0.19	lasso	6	0.18	4.3e-14	-5.3	5.6	1.8e-08	-0.69	0.40	0.60	FALSE
7	METSIM	Adipose	FES	0.08	0.06	lasso	3	0.05	6.8e-08	-5.1	5.3	1.1e-07	-0.64	0.70	0.30	FALSE
8	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FES	0.06	0.05	blup	46	0.06	1.9e-05	-6.2	5.6	2.3e-08	-0.80	0.01	0.98	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	FES	0.06	0.05	blup	46	0.07	7.4e-14	-5.8	7.4	1.7e-13	-0.88	0.02	0.98	TRUE
10	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FES	0.06	0.02	blup	46	0.02	2.4e-02	-5.8	6.7	1.7e-11	-0.76	0.01	0.72	FALSE
11	The Cancer Genome Atlas	Colon Adenocarcinoma	FES	0.08	0.07	blup	46	0.06	3.4e-04	-6.6	6.6	3.8e-11	-0.91	0.00	0.99	FALSE
12	The Cancer Genome Atlas	Glioblastoma Multiforme	FES	0.12	0.06	enet	6	0.06	5.7e-03	-6.4	6.1	1.4e-09	-0.92	0.00	0.91	FALSE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FES	0.06	0.03	blup	46	0.05	5.6e-06	-6.4	6.4	1.3e-10	-0.80	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FES	0.10	0.07	enet	5	0.05	2.8e-06	-6.3	6.4	1.4e-10	-0.95	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	FES	0.05	0.04	lasso	2	0.04	2.2e-05	-5.8	6.5	1.0e-10	-0.86	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FES	0.08	0.07	enet	7	0.08	4.2e-09	-5.8	6.5	8.5e-11	-0.79	0.10	0.90	FALSE
17	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FES	0.13	0.16	lasso	2	0.14	6.1e-10	-5.8	5.7	1.3e-08	-0.69	0.20	0.80	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	FES	0.12	0.09	lasso	5	0.08	4.1e-09	-5.8	5.8	7.7e-09	-0.77	0.12	0.88	FALSE
19	The Cancer Genome Atlas	Stomach Adenocarcinoma	FES	0.04	0.01	blup	46	0.02	1.7e-02	-6.2	7.3	3.5e-13	-0.78	0.01	0.66	FALSE
20	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FES	0.32	0.26	lasso	2	0.25	2.0e-09	-5.8	5.8	6.3e-09	-0.70	0.18	0.82	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	FES	0.30	0.30	lasso	7	0.32	1.3e-31	-5.8	6.3	3.1e-10	-0.83	0.19	0.81	FALSE