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chr15:84,151,637-85,895,721

Best TWAS P=1.05e-09 · Best GWAS P=1.72e-08 conditioned to 0.815

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	AC103965.1	0.24	0.14	lasso	6	0.15	2.6e-12	-5.5	5.5	3.3e-08	-0.92	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	RN7SL417P	0.07	0.06	lasso	7	0.05	1.3e-04	-5.6	-5.8	5.1e-09	0.92	0.02	0.96	FALSE
3	GTEx	Adipose Subcutaneous	RP11-182J1.14	0.11	0.11	lasso	9	0.12	8.1e-10	-5.6	-5.7	1.4e-08	0.91	0.02	0.98	FALSE
4	GTEx	Adipose Subcutaneous	CSPG4P11	0.19	0.17	lasso	5	0.20	7.9e-16	-5.5	5.5	4.4e-08	-0.93	0.01	0.99	FALSE
5	GTEx	Adipose Visceral Omentum	AC103965.1	0.12	0.13	lasso	5	0.10	1.0e-05	-5.5	5.7	1.2e-08	-0.95	0.02	0.98	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-182J1.14	0.17	0.05	enet	18	0.08	6.9e-05	-5.3	-5.3	1.1e-07	0.85	0.04	0.94	FALSE
7	GTEx	Adrenal Gland	AC103965.1	0.09	0.00	enet	5	-0.01	7.7e-01	-5.6	5.6	1.7e-08	-0.95	0.02	0.77	FALSE
8	GTEx	Artery Aorta	AC103965.1	0.10	0.12	lasso	3	0.10	3.9e-06	-5.3	5.5	5.0e-08	-0.96	0.02	0.98	FALSE
9	GTEx	Artery Aorta	RP11-182J1.16	0.11	0.12	lasso	3	0.11	1.6e-06	-5.5	5.4	8.8e-08	-0.96	0.01	0.98	FALSE
10	GTEx	Artery Aorta	RP11-182J1.14	0.22	0.17	enet	13	0.20	3.0e-11	-5.5	-5.3	1.2e-07	0.89	0.02	0.98	FALSE
11	GTEx	Artery Aorta	CSPG4P11	0.11	0.10	lasso	4	0.08	3.1e-05	-5.5	5.6	2.7e-08	-0.96	0.01	0.98	FALSE
12	GTEx	Artery Tibial	AC103965.1	0.27	0.26	enet	31	0.30	1.8e-23	-5.6	6.1	1.1e-09	-0.91	0.01	0.99	TRUE
13	GTEx	Artery Tibial	RP11-182J1.16	0.11	0.09	enet	14	0.08	4.1e-07	-5.5	5.3	1.1e-07	-0.89	0.02	0.98	FALSE
14	GTEx	Artery Tibial	CSPG4P11	0.16	0.24	lasso	4	0.23	3.0e-18	-5.6	5.6	1.7e-08	-0.94	0.01	0.99	FALSE
15	GTEx	Brain Cerebellar Hemisphere	CSPG4P11	0.30	0.21	lasso	3	0.16	7.6e-05	-5.5	-5.5	3.3e-08	0.93	0.02	0.96	FALSE
16	GTEx	Brain Cerebellum	CSPG4P11	0.28	0.23	lasso	5	0.28	9.0e-09	-5.6	-5.7	1.2e-08	0.94	0.01	0.98	FALSE
17	GTEx	Brain Cortex	AC103965.1	0.17	0.19	lasso	3	0.16	4.3e-05	-5.5	5.6	2.4e-08	-0.95	0.02	0.95	FALSE
18	GTEx	Brain Cortex	RP11-182J1.14	0.24	0.03	enet	14	0.16	3.2e-05	-5.6	-5.6	1.6e-08	0.72	0.02	0.74	FALSE
19	GTEx	Brain Frontal Cortex BA9	AC103965.1	0.27	0.17	lasso	7	0.16	6.0e-05	-5.6	5.2	2.3e-07	-0.89	0.02	0.95	FALSE
20	GTEx	Brain Hypothalamus	AC103965.1	0.21	0.24	lasso	6	0.21	1.4e-05	-5.6	5.3	9.8e-08	-0.91	0.02	0.96	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	AC103965.1	0.29	0.23	enet	21	0.27	6.9e-08	-5.5	5.9	3.1e-09	-0.88	0.01	0.98	FALSE
22	GTEx	Brain Putamen basal ganglia	AC103965.1	0.26	0.19	lasso	7	0.22	4.5e-06	-5.6	5.6	2.9e-08	-0.93	0.02	0.98	FALSE
23	GTEx	Breast Mammary Tissue	AC103965.1	0.13	0.11	lasso	1	0.13	2.9e-07	-5.6	5.6	1.9e-08	-0.96	0.01	0.99	FALSE
24	GTEx	Breast Mammary Tissue (Male)	AC103965.1	0.24	0.14	lasso	4	0.11	1.4e-03	-5.5	5.3	1.1e-07	-0.92	0.02	0.89	FALSE
25	GTEx	Breast Mammary Tissue (Male)	RP11-182J1.14	0.04	-0.01	enet	1	-0.01	5.9e-01	-5.5	-5.5	3.5e-08	0.93	0.02	0.35	FALSE
26	GTEx	Cells Transformed fibroblasts	AC103965.1	0.15	0.09	lasso	7	0.11	1.3e-08	-5.5	5.4	5.2e-08	-0.84	0.01	0.99	FALSE
27	GTEx	Cells Transformed fibroblasts	CSPG4P11	0.19	0.18	enet	17	0.17	9.8e-13	-5.5	5.3	9.9e-08	-0.91	0.01	0.99	FALSE
28	GTEx	Colon Sigmoid	RN7SL417P	0.17	0.06	lasso	4	0.12	6.1e-05	-5.5	-5.8	8.3e-09	0.86	0.02	0.94	FALSE
29	GTEx	Colon Sigmoid	RP11-182J1.14	0.31	0.29	lasso	9	0.30	2.7e-11	-5.6	-5.9	4.4e-09	0.93	0.01	0.98	FALSE
30	GTEx	Colon Transverse	RP11-182J1.14	0.23	0.19	enet	27	0.18	3.9e-09	-5.6	-5.3	9.2e-08	0.85	0.02	0.98	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	RP11-182J1.14	0.16	0.16	enet	16	0.17	1.1e-06	-5.1	-5.2	2.2e-07	0.82	0.09	0.90	FALSE
32	GTEx	Esophagus Mucosa	UBE2Q2P1	0.38	0.26	enet	37	0.28	3.7e-19	-5.6	-5.5	4.3e-08	0.84	0.01	0.99	FALSE
33	GTEx	Esophagus Mucosa	NMB	0.07	0.02	lasso	1	0.02	3.1e-02	-5.3	5.3	1.3e-07	-0.78	0.06	0.75	FALSE
34	GTEx	Esophagus Mucosa	RP11-182J1.16	0.20	0.05	lasso	5	0.10	1.8e-07	-5.6	5.3	1.4e-07	-0.75	0.02	0.98	FALSE
35	GTEx	Esophagus Muscularis	AC103965.1	0.18	0.14	enet	16	0.14	7.6e-09	-5.5	5.7	1.3e-08	-0.93	0.02	0.98	FALSE
36	GTEx	Esophagus Muscularis	RP11-182J1.14	0.12	0.09	enet	16	0.09	4.6e-06	-5.5	-5.3	1.1e-07	0.91	0.02	0.98	FALSE
37	GTEx	Esophagus Muscularis	CSPG4P11	0.12	0.16	lasso	5	0.18	4.0e-11	-5.5	5.6	2.6e-08	-0.95	0.01	0.99	FALSE
38	GTEx	Heart Atrial Appendage	RP11-182J1.14	0.06	0.05	lasso	3	0.05	3.6e-03	-5.6	-5.6	2.1e-08	0.92	0.02	0.89	FALSE
39	GTEx	Heart Left Ventricle	AC103965.1	0.16	0.13	enet	14	0.12	7.0e-07	-5.4	5.3	9.1e-08	-0.88	0.02	0.98	FALSE
40	GTEx	Heart Left Ventricle	CSPG4P11	0.11	0.02	lasso	5	0.00	2.2e-01	-5.5	5.4	6.5e-08	-0.94	0.02	0.88	FALSE
41	GTEx	Nerve Tibial	AC103965.1	0.20	0.22	enet	17	0.27	5.1e-19	-5.6	5.5	3.6e-08	-0.93	0.02	0.98	FALSE
42	GTEx	Nerve Tibial	CSPG4P11	0.23	0.23	lasso	9	0.27	3.0e-19	-5.6	5.1	3.0e-07	-0.92	0.01	0.99	FALSE
43	GTEx	Pancreas	NMB	0.17	0.18	lasso	3	0.14	2.3e-06	-5.3	5.3	9.1e-08	-0.78	0.07	0.93	FALSE
44	GTEx	Pancreas	AC103965.1	0.29	0.23	lasso	9	0.18	2.8e-08	-5.6	5.6	2.0e-08	-0.93	0.01	0.99	FALSE
45	GTEx	Pituitary	AC103965.1	0.30	0.16	enet	10	0.24	8.4e-07	-5.3	5.5	3.0e-08	-0.87	0.02	0.97	FALSE
46	GTEx	Prostate	RP11-182J1.14	0.25	0.09	enet	25	0.09	2.9e-03	-5.5	-5.2	1.8e-07	0.74	0.05	0.77	FALSE
47	GTEx	Spleen	NMB	0.14	0.17	lasso	4	0.15	1.1e-04	-4.9	5.1	2.6e-07	-0.78	0.07	0.80	FALSE
48	GTEx	Spleen	GOLGA6L5	0.46	0.34	lasso	9	0.40	2.0e-11	3.8	5.4	7.4e-08	-0.73	0.08	0.91	FALSE
49	GTEx	Stomach	AC103965.1	0.14	0.11	lasso	3	0.10	1.1e-05	-5.5	5.2	1.9e-07	-0.87	0.02	0.97	FALSE
50	GTEx	Testis	AC103965.1	0.07	0.07	lasso	2	0.06	1.6e-03	-5.6	5.6	2.1e-08	-0.96	0.02	0.97	FALSE
51	GTEx	Testis	RP11-182J1.14	0.10	0.19	lasso	1	0.17	6.7e-08	-5.6	-5.6	1.9e-08	0.96	0.01	0.99	FALSE
52	GTEx	Thyroid	AC103965.1	0.30	0.25	lasso	7	0.25	1.8e-19	-5.5	5.4	8.3e-08	-0.93	0.01	0.99	FALSE
53	METSIM	Adipose	NMB	0.08	0.10	lasso	9	0.10	6.8e-15	-5.0	5.2	2.5e-07	-0.77	0.17	0.83	FALSE
54	YFS	Blood	NMB	0.05	0.09	lasso	4	0.09	1.9e-26	-5.5	5.5	3.9e-08	-0.77	0.03	0.97	FALSE
55	The Cancer Genome Atlas	Esophageal Carcinoma	LOC388152	0.10	0.08	enet	2	0.08	1.8e-03	-5.5	5.6	2.6e-08	-0.96	0.00	0.75	FALSE
56	The Cancer Genome Atlas	Glioblastoma Multiforme	LOC388152	0.12	0.08	lasso	3	0.08	1.9e-03	-5.6	5.6	1.7e-08	-1.00	0.00	0.69	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GOLGA6L5	0.04	0.01	blup	7	0.03	4.9e-04	-5.3	5.1	2.6e-07	-0.79	0.00	0.97	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC388152	0.05	0.05	blup	4	0.05	3.9e-06	-5.6	5.2	1.8e-07	-0.96	0.00	1.00	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC388152	0.12	0.10	blup	4	0.10	4.9e-12	-5.6	5.1	2.9e-07	-0.96	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC388152	0.02	0.03	lasso	1	0.02	1.2e-03	-5.5	5.5	3.1e-08	-0.96	0.00	0.93	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBE2Q2P1	0.03	0.03	lasso	3	0.02	9.2e-04	-5.6	-5.7	1.0e-08	0.94	0.00	0.94	FALSE
62	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LOC388152	0.04	0.05	enet	2	0.05	4.2e-04	-5.6	5.6	2.4e-08	-0.96	0.00	0.90	FALSE
63	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC388152	0.08	0.11	lasso	3	0.11	2.4e-05	-5.6	5.6	1.7e-08	-1.00	0.00	0.98	FALSE
64	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GOLGA6L5	0.10	0.04	enet	2	0.10	9.9e-05	3.5	5.2	1.9e-07	-0.78	0.00	0.84	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	NMB	0.17	0.30	enet	12	0.29	5.3e-31	-5.5	5.6	1.7e-08	-0.76	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC388152	0.18	0.14	blup	4	0.13	2.1e-05	-5.6	5.1	3.0e-07	-0.96	0.00	0.99	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	LOC388152	0.29	0.26	enet	3	0.27	2.1e-26	-5.6	5.3	1.0e-07	-0.96	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	NMB	0.11	0.11	lasso	3	0.09	1.8e-09	-5.3	-5.4	7.7e-08	0.78	0.01	0.99	FALSE