Best TWAS P=1.26e-08 · Best GWAS P=3.1e-08 conditioned to 0.605
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP11-231C14.4 | 0.06 | 0.07 | enet | 5 | 0.07 | 4.7e-06 | 5.5 | -5.2 | 2.1e-07 | -0.93 | 0.02 | 0.98 | FALSE |
2 | GTEx | Adipose Visceral Omentum | INO80E | 0.14 | 0.14 | enet | 17 | 0.19 | 3.7e-10 | -5.4 | 5.1 | 2.9e-07 | 0.77 | 0.03 | 0.97 | FALSE |
3 | GTEx | Adipose Visceral Omentum | AC009133.12 | 0.05 | 0.01 | lasso | 2 | 0.00 | 2.3e-01 | -5.5 | -5.2 | 1.9e-07 | -0.79 | 0.04 | 0.64 | FALSE |
4 | GTEx | Artery Tibial | INO80E | 0.23 | 0.15 | enet | 21 | 0.19 | 6.7e-15 | -5.2 | 5.2 | 1.7e-07 | 0.83 | 0.04 | 0.96 | FALSE |
5 | GTEx | Breast Mammary Tissue | INO80E | 0.17 | 0.12 | enet | 14 | 0.13 | 2.3e-07 | 4.4 | 5.7 | 1.4e-08 | 0.84 | 0.03 | 0.97 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | MAPK3 | 0.12 | 0.05 | lasso | 10 | 0.04 | 3.7e-04 | 5.2 | 5.7 | 1.3e-08 | 0.94 | 0.03 | 0.97 | TRUE |
7 | GTEx | Cells Transformed fibroblasts | PPP4C | 0.04 | 0.06 | lasso | 1 | 0.05 | 8.0e-05 | -5.2 | 5.2 | 2.0e-07 | 0.83 | 0.03 | 0.95 | FALSE |
8 | GTEx | Colon Transverse | RP11-231C14.4 | 0.07 | 0.04 | enet | 8 | 0.06 | 8.0e-04 | -5.2 | -5.2 | 1.6e-07 | -0.79 | 0.02 | 0.90 | FALSE |
9 | GTEx | Esophagus Gastroesophageal Junction | INO80E | 0.15 | 0.00 | lasso | 6 | 0.02 | 4.3e-02 | -5.5 | 5.2 | 2.2e-07 | 0.74 | 0.03 | 0.84 | FALSE |
10 | GTEx | Esophagus Muscularis | INO80E | 0.10 | 0.11 | enet | 20 | 0.07 | 4.6e-05 | -5.4 | 5.6 | 2.3e-08 | 0.83 | 0.03 | 0.97 | FALSE |
11 | GTEx | Heart Atrial Appendage | INO80E | 0.14 | 0.17 | lasso | 3 | 0.19 | 5.7e-09 | -5.4 | 5.3 | 1.4e-07 | 0.82 | 0.03 | 0.97 | FALSE |
12 | GTEx | Heart Left Ventricle | INO80E | 0.06 | 0.07 | lasso | 7 | 0.08 | 6.1e-05 | -5.3 | 5.5 | 4.4e-08 | 0.91 | 0.03 | 0.94 | FALSE |
13 | GTEx | Nerve Tibial | INO80E | 0.26 | 0.34 | enet | 30 | 0.38 | 3.5e-28 | -5.2 | 5.3 | 1.3e-07 | 0.81 | 0.03 | 0.97 | FALSE |
14 | GTEx | Ovary | RP11-231C14.4 | 0.22 | 0.12 | lasso | 5 | 0.11 | 1.1e-03 | 5.5 | -5.2 | 2.0e-07 | -0.87 | 0.02 | 0.78 | FALSE |
15 | GTEx | Prostate | INO80E | 0.18 | 0.23 | lasso | 2 | 0.23 | 1.6e-06 | -5.5 | 5.4 | 5.3e-08 | 0.84 | 0.03 | 0.96 | FALSE |
16 | GTEx | Small Intestine Terminal Ileum | MAPK3 | 0.17 | 0.01 | lasso | 5 | 0.04 | 5.4e-02 | -5.3 | 5.3 | 1.5e-07 | 0.79 | 0.03 | 0.69 | FALSE |
17 | GTEx | Testis | INO80E | 0.15 | 0.20 | lasso | 3 | 0.19 | 8.3e-09 | -5.2 | 5.2 | 2.0e-07 | 0.84 | 0.03 | 0.97 | FALSE |
18 | GTEx | Whole Blood | MAPK3 | 0.09 | 0.05 | enet | 30 | 0.09 | 7.8e-09 | 5.5 | 5.2 | 2.4e-07 | 0.82 | 0.02 | 0.98 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | TAOK2 | 0.04 | 0.02 | blup | 188 | 0.03 | 1.7e-04 | 5.0 | 5.2 | 1.9e-07 | 0.86 | 0.03 | 0.96 | FALSE |
20 | ROSMAP | Brain Pre-frontal Cortex | INO80E | 0.08 | 0.13 | lasso | 2 | 0.12 | 1.6e-15 | -5.2 | 5.2 | 1.7e-07 | 0.83 | 0.03 | 0.97 | FALSE |
21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KCTD13 | 0.02 | 0.02 | lasso | 2 | 0.02 | 3.9e-03 | 5.2 | -5.2 | 1.8e-07 | -0.99 | 0.02 | 0.78 | FALSE |