Best TWAS P=4.55e-09 · Best GWAS P=3.66e-07 conditioned to 0.867
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | NEIL2 | 0.21 | 0.07 | enet | 18 | 0.13 | 2.8e-10 | -4.9 | -5.2 | 1.6e-07 | 0.87 | 0.00 | 0.99 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Male) | FAM85A | 0.14 | 0.03 | enet | 16 | 0.09 | 4.3e-03 | 4.3 | -5.2 | 2.3e-07 | 0.60 | 0.07 | 0.31 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | FDFT1 | 0.11 | 0.06 | lasso | 5 | 0.12 | 3.0e-09 | -4.0 | -5.6 | 1.9e-08 | 0.76 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | NEIL2 | 0.19 | 0.20 | lasso | 4 | 0.24 | 4.0e-11 | -5.1 | -5.5 | 4.2e-08 | 0.94 | 0.00 | 0.99 | FALSE |
| 5 | GTEx | Muscle Skeletal | NEIL2 | 0.11 | 0.08 | lasso | 5 | 0.05 | 4.7e-06 | -4.9 | -5.2 | 2.5e-07 | 0.86 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Nerve Tibial | NEIL2 | 0.34 | 0.20 | lasso | 6 | 0.25 | 8.1e-18 | -4.9 | -5.2 | 1.9e-07 | 0.93 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Thyroid | NEIL2 | 0.14 | 0.08 | enet | 8 | 0.09 | 2.9e-07 | -5.1 | -5.9 | 4.6e-09 | 0.88 | 0.00 | 1.00 | TRUE |
| 8 | GTEx | Whole Blood | NEIL2 | 0.09 | 0.01 | enet | 15 | 0.03 | 1.5e-03 | 4.2 | -5.1 | 2.8e-07 | 0.73 | 0.02 | 0.95 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GATA4 | 0.01 | 0.00 | blup | 125 | 0.01 | 2.9e-03 | -5.1 | 5.5 | 4.1e-08 | -0.79 | 0.01 | 0.91 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NEIL2 | 0.05 | 0.07 | enet | 5 | 0.08 | 8.1e-09 | -5.1 | -5.3 | 1.3e-07 | 0.95 | 0.00 | 1.00 | FALSE |