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chr7:71,652,312-73,843,516

Best TWAS P=6.31e-67 · Best GWAS P=1.25e-58 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	NSUN5P2	0.02	0.00	blup	108	0.02	3.2e-03	-2.59	-5.6	2.4e-08	0.41	0.04	0.16	FALSE
2	GTEx	Adipose Subcutaneous	MLXIPL	0.11	0.07	enet	16	0.07	1.6e-06	-16.10	-16.9	5.6e-64	0.85	0.05	0.95	FALSE
3	GTEx	Adipose Visceral Omentum	MLXIPL	0.16	0.02	lasso	3	0.03	7.8e-03	-15.60	-16.2	7.0e-59	0.81	0.18	0.79	FALSE
4	GTEx	Adipose Visceral Omentum	NSUN5	0.07	0.03	enet	11	0.04	4.0e-03	-16.00	-14.2	1.0e-45	0.74	0.06	0.34	FALSE
5	GTEx	Artery Aorta	TBL2	0.59	0.24	enet	19	0.34	9.0e-20	4.18	5.5	4.8e-08	-0.21	1.00	0.00	FALSE
6	GTEx	Artery Aorta	POM121B	0.12	0.04	lasso	4	0.08	3.6e-05	-3.82	7.6	2.6e-14	-0.48	0.33	0.13	FALSE
7	GTEx	Brain Caudate basal ganglia	TBL2	0.24	0.02	enet	15	0.08	2.6e-03	-0.18	-6.9	5.3e-12	0.28	0.05	0.06	FALSE
8	GTEx	Breast Mammary Tissue	TBL2	0.41	0.14	enet	42	0.18	2.0e-09	4.18	6.0	2.6e-09	-0.25	0.87	0.02	TRUE
9	GTEx	Breast Mammary Tissue (Female)	TBL2	0.26	-0.01	enet	32	0.00	3.3e-01	-0.96	8.2	3.0e-16	-0.37	0.02	0.42	FALSE
10	GTEx	Cells Transformed fibroblasts	MLXIPL	0.13	0.06	enet	6	0.09	2.2e-07	-16.00	-17.2	1.4e-66	0.93	0.04	0.96	FALSE
11	GTEx	Esophagus Muscularis	MLXIPL	0.06	0.03	enet	10	0.03	1.1e-02	-3.64	-7.0	2.1e-12	0.42	0.08	0.76	FALSE
12	GTEx	Heart Atrial Appendage	POM121B	0.08	0.03	enet	17	0.04	9.7e-03	-3.82	9.1	1.4e-19	-0.49	0.05	0.17	FALSE
13	GTEx	Heart Left Ventricle	MLXIPL	0.14	0.00	enet	24	0.01	1.3e-01	-3.64	-9.4	5.5e-21	0.51	0.11	0.43	FALSE
14	GTEx	Lung	MLXIPL	0.10	0.07	enet	14	0.07	6.3e-06	-16.10	-13.3	2.8e-40	0.75	0.03	0.94	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	MLXIPL	0.11	0.11	lasso	3	0.06	2.7e-04	-16.00	-15.6	5.2e-55	0.76	0.02	0.95	FALSE
16	GTEx	Skin Sun Exposed Lower leg	MLXIPL	0.12	0.09	lasso	4	0.06	6.1e-06	-16.00	-16.6	4.4e-62	0.84	0.09	0.91	FALSE
17	GTEx	Spleen	NCF1B	0.22	0.10	enet	9	0.08	5.1e-03	-12.80	14.4	5.2e-47	-0.88	0.04	0.38	FALSE
18	GTEx	Testis	MLXIPL	0.10	0.00	lasso	3	0.00	3.3e-01	-8.66	-14.2	1.3e-45	0.74	0.04	0.39	FALSE
19	GTEx	Testis	ABHD11	0.13	0.00	enet	22	0.03	1.7e-02	-0.96	-6.7	1.9e-11	0.26	0.04	0.07	FALSE
20	GTEx	Thyroid	MLXIPL	0.23	0.14	lasso	7	0.15	2.1e-11	-16.10	-17.1	3.2e-65	0.89	0.03	0.97	FALSE
21	METSIM	Adipose	BCL7B	0.10	0.02	enet	20	0.05	1.2e-07	-15.60	-9.4	8.0e-21	0.17	0.01	0.99	TRUE
22	METSIM	Adipose	MLXIPL	0.12	0.14	lasso	4	0.13	1.8e-19	-16.00	-17.1	2.4e-65	0.97	0.06	0.94	FALSE
23	METSIM	Adipose	POM121	0.05	0.03	blup	130	0.03	5.4e-06	-3.41	-6.0	2.0e-09	0.30	0.77	0.11	FALSE
24	NTR	Blood	WBSCR22	0.03	0.01	bslmm	270	0.01	1.2e-05	-3.55	-7.5	8.0e-14	0.63	0.62	0.20	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	POM121B	0.09	0.02	blup	18	0.04	4.6e-06	-15.40	11.4	4.3e-30	-0.62	0.01	0.54	FALSE
26	YFS	Blood	NSUN5	0.01	0.01	lasso	2	0.00	1.5e-02	6.89	7.0	1.9e-12	-0.44	0.04	0.03	TRUE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	MLXIPL	0.06	0.05	lasso	2	0.05	5.1e-10	-16.10	-16.0	2.0e-57	0.99	0.00	1.00	TRUE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BCL7B	0.02	0.01	blup	5	0.02	2.7e-03	-16.10	16.4	2.2e-60	-0.84	0.00	0.73	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BCL7B	0.08	0.01	enet	4	0.01	1.4e-02	-16.00	9.2	2.6e-20	-0.07	0.00	0.24	TRUE
30	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	BCL7B	0.08	0.04	blup	5	0.06	1.0e-03	-16.10	17.3	6.3e-67	-0.87	0.00	0.90	TRUE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	MLXIPL	0.04	0.03	lasso	1	0.02	2.3e-03	-16.10	-16.1	1.2e-58	1.00	0.00	0.98	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	MLXIPL	0.08	0.05	enet	4	0.05	5.3e-06	-16.10	-15.6	1.4e-54	0.94	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	BCL7B	0.05	0.01	blup	5	0.03	1.3e-03	-16.10	9.7	3.0e-22	-0.61	0.00	0.61	FALSE