Hub : Genes

FDFT1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0610	0.0280	4.9e-04	0.043	NA	0.025	NA	0.039	2.0e-04	NA	3.6e-03	NA	3.4e-04
2	GTEx	Artery Aorta	0.0930	0.0470	2.4e-03	0.024	NA	0.024	NA	0.033	1.6e-02	NA	1.8e-02	NA	6.1e-03
3	GTEx	Artery Tibial	0.1391	0.0448	1.3e-07	0.169	NA	0.140	NA	0.162	3.2e-13	NA	4.1e-11	NA	1.1e-12
4	GTEx	Cells Transformed fibroblasts	0.1140	0.0370	2.8e-06	0.063	NA	0.098	NA	0.119	1.8e-05	NA	8.2e-08	NA	3.0e-09
5	GTEx	Muscle Skeletal	0.1501	0.0423	2.4e-04	0.032	NA	0.013	NA	0.015	3.8e-04	NA	1.9e-02	NA	1.2e-02
6	METSIM	Adipose	0.1154	0.0303	3.5e-06	0.022	0.047	0.053	0.050	0.036	2.6e-04	1.2e-07	2.1e-08	5.9e-08	3.2e-06
7	NTR	Blood	0.1688	0.0259	0.0e+00	0.067	0.138	0.137	0.146	0.130	9.2e-21	4.3e-42	5.1e-42	7.4e-45	9.9e-40
8	ROSMAP	Brain Pre-frontal Cortex	0.0702	0.0270	2.5e-04	0.027	0.032	0.024	0.038	0.035	1.7e-04	5.4e-05	3.8e-04	1.1e-05	2.5e-05
9	TCGA	Breast Invasive Carcinoma	0.0225	0.0128	4.1e-03	0.004	0.007	0.006	NA	0.003	4.7e-02	1.1e-02	1.6e-02	NA	5.5e-02
10	TCGA	Prostate Adenocarcinoma	0.0699	0.0285	1.5e-05	0.039	0.045	0.047	NA	0.048	5.9e-05	1.6e-05	1.0e-05	NA	8.8e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.7	1.1	2.2	1.4	1.4	1.2	-0.9	-1.5	1.0	1.1	0.3	-0.5	-0.5
Bipolar Disorder or Schizophrenia	1.3	3.3	6.0	2.4	2.5	2.4	1.4	-2.1	0.2	-0.4	1.5	-2.2	-1.4
Depressed Affect (Nagel 2018)	0.4	0.9	2.2	-0.9	-1.5	-0.7	-1.2	-0.3	-0.8	-1.4	-1.0	0.3	0.7
Depression (Nagel 2018)	2.3	3.5	6.3	-1.9	-1.3	-2.4	-1.8	-0.5	-1.9	-2.5	-1.9	1.5	2.2
Intelligence (Savage-Jansen 2018)	0.7	2.1	5.1	-1.0	-1.1	-1.3	-1.5	-0.4	-1.5	-1.5	-1.8	1.2	2.3
Neuroticism (Nagel 2018)	0.3	0.8	2.6	-0.9	-1.6	-0.9	-1.1	-0.0	-0.1	-1.2	-0.5	0.7	0.4
Schizophrenia (2018)	1.6	3.4	6.2	1.9	2.1	2.1	2.5	-1.5	-0.6	-1.4	1.7	-2.4	-1.3
Schizophrenia vs Biploar Disorder	1.8	2.4	5.8	2.0	1.4	1.8	2.3	-0.9	0.6	0.4	1.0	-2.4	-0.9
Worry (Nagel 2018)	0.2	0.5	1.1	-0.7	-1.1	-1.0	-0.5	0.0	-0.5	-0.9	0.7	0.7	-0.2
Alzheimer’s Disease (in mother)	0.4	0.5	1.3	0.7	0.4	0.2	-0.5	1.1	0.6	1.0	-0.3	0.7	-0.7
Alzheimer’s Disease (in father)	0.2	0.3	0.7	-0.6	-0.8	-0.5	0.1	0.1	-0.2	-0.9	-0.7	0.3	0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	2.2	-0.1	-0.7	-0.5	-0.7	1.5	-0.0	-0.3	-1.1	1.2	-0.1
Crohns Disease (2017)	0.6	1.3	5.3	0.8	0.0	1.0	1.7	0.3	0.9	0.5	1.5	-0.5	-2.3
Irritable Bowel Disease (IBD)	0.6	1.5	4.2	-0.2	-0.3	-0.2	-0.7	2.0	1.5	1.7	-0.4	1.3	-1.9
Ulcerative Colitis (UC)	1.8	3.3	8.9	-1.0	-0.3	-1.3	-2.2	3.0	1.5	1.8	-2.0	2.4	-0.9
Major Depression (MDD)	0.4	0.5	1.8	-0.7	-1.2	-0.3	-0.8	0.0	-0.2	0.2	-1.3	0.2	0.3
Reaction Time	0.3	0.5	1.5	-0.6	-0.8	-0.2	-0.9	-0.0	-0.6	0.2	-1.0	1.2	0.3
Verbal and Numeric Reasoning (VNR)	1.6	3.9	10.1	-1.6	-1.6	-2.1	-2.2	0.2	-1.4	-1.2	-2.7	2.0	3.2
Breast Cancer	0.8	1.9	5.5	1.2	1.0	1.6	1.8	-2.4	0.0	-0.7	1.2	-1.8	0.3
Ovarian Cancer	0.5	0.6	3.3	0.9	0.3	1.1	-0.4	-0.6	1.8	0.4	0.2	-0.3	0.2
Prostate Cancer	3.1	4.3	13.6	2.5	2.7	2.2	1.0	-0.6	3.7	2.0	-0.2	-1.7	-1.6
Age at First Birth	1.5	2.1	6.7	-1.5	-2.6	-1.2	-1.3	1.6	0.2	-0.3	-1.8	1.8	0.1
Bipolar Disorder (2011)	1.0	1.0	4.1	1.1	0.7	1.1	-1.1	-2.0	-0.2	0.9	0.2	-0.0	0.7
Body Mass Index (BMI) (2010)	3.4	4.6	8.3	2.9	2.0	2.9	2.2	-1.0	1.8	0.8	2.2	-2.8	-1.9
Coronary Artery Disease (CAD)	0.9	1.0	5.7	0.4	-0.2	0.4	2.4	0.9	-0.8	-0.9	0.5	-1.2	-0.5
Crohns Disease (2012)	0.1	0.2	0.8	0.2	0.2	0.2	0.2	-0.0	0.9	-0.5	-0.2	0.4	-0.9
Mean Putamen Volume	3.3	3.8	6.7	2.6	1.6	2.5	0.8	-0.8	1.6	2.4	2.4	-1.8	-1.9
Fasting Glucose	0.4	0.5	2.4	-0.4	0.6	-0.4	-1.5	-1.1	-0.3	-0.6	-0.6	0.2	0.4
HbA1C	0.3	0.3	0.8	0.5	0.6	0.6	0.9	0.2	0.2	-0.3	0.4	-0.7	-0.8
HDL Cholesterol	0.1	0.1	0.5	-0.2	0.5	-0.0	0.5	-0.7	0.1	-0.1	-0.2	-0.2	0.3
LDL Cholesterol	0.2	0.4	0.9	-0.5	-0.4	-1.0	0.6	0.9	-0.7	-0.3	0.8	0.2	-0.2
Lupus	6.5	9.8	26.8	3.8	5.2	4.3	3.6	-2.1	1.4	0.8	1.2	-3.6	-1.9
Neuroticism (2016)	17.1	24.7	37.6	-6.1	-6.0	-5.8	-4.6	3.8	-3.8	-4.2	-4.0	6.1	4.3
Primary Biliary Cirrhosis	1.8	2.6	12.0	0.6	1.2	0.7	2.1	0.6	1.6	0.5	1.7	-1.1	-3.5
Rheumatoid Arthritis	0.4	0.6	1.8	-0.5	1.1	-0.7	-0.6	0.2	-1.0	-0.7	0.2	1.3	-0.0
Schizophrenia (2014)	1.9	4.2	7.8	2.7	2.2	2.8	2.3	-1.9	0.1	-0.9	1.3	-2.6	-1.9
Triglycerides	10.4	17.1	31.6	-4.7	-4.5	-4.3	-5.6	0.6	-3.3	-2.6	-4.2	4.6	4.6
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.6	1.1	0.9	1.1	0.7	-2.1	-1.3	-0.9	0.6	-1.4	0.6
Ulcerative Colitis	3.0	4.3	12.8	-1.6	-0.7	-1.9	-3.6	1.7	0.7	1.6	-2.4	3.3	0.7
Blood Eosinophil Count	0.1	0.4	0.8	0.8	0.4	0.5	-0.7	-0.9	-0.1	0.8	0.9	0.0	0.5
Blood Platelet Count	0.2	2.7	5.8	-1.2	-0.8	-2.4	-1.1	1.6	-2.4	-1.8	-0.2	1.8	1.8
Blood Red Count	0.9	8.9	22.1	-3.3	-1.7	-4.4	-4.5	3.3	-0.5	-0.3	-0.8	4.7	-1.0
Blood White Count	0.1	0.6	1.4	-0.8	-1.2	-0.5	-1.1	-0.4	-0.4	-0.6	-0.7	1.0	0.5
Heel T-Score	0.1	0.9	2.7	0.3	-1.1	0.0	-1.5	1.6	0.3	1.4	0.3	0.4	-0.5
BMI	0.1	0.8	2.5	-0.4	-0.0	-0.3	-0.5	-1.5	-1.1	-1.0	-0.3	0.1	1.6
Height	0.3	6.2	21.9	2.1	1.0	0.0	-1.3	3.6	2.7	4.7	0.8	1.7	-3.1
Waist Hip Ratio (WHR)	0.9	4.0	14.3	-1.8	-1.9	-1.5	0.4	-1.4	-3.2	-3.8	0.3	-0.3	2.2
Systolic Blood Pressure	0.4	2.2	6.1	0.4	1.9	1.4	1.8	0.7	1.5	0.8	2.5	-1.3	-1.3
Smoking Status	0.2	0.6	1.6	0.1	-0.2	0.3	1.3	-0.2	-0.9	-1.1	-0.7	-1.0	0.4
Allergy or Eczema	0.4	1.1	3.7	-0.6	0.3	-1.3	-0.4	0.2	-1.9	-0.7	1.7	0.2	1.0
Cardiovascular Disease	0.3	0.9	3.2	0.8	1.8	0.1	1.0	-0.5	-0.9	-0.9	1.1	-0.8	0.7
Hypothyroidism (self reported)	0.2	0.5	1.5	-0.7	0.3	-0.1	-0.7	-1.1	0.2	1.2	-0.5	-0.3	0.6
Respiratory disease	0.5	1.1	2.6	-0.8	0.5	-1.5	-0.7	-0.0	-1.5	-1.3	0.7	1.6	0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.3	-0.9	-0.0	-1.1	0.9	0.7	-0.4	-0.2	0.3	0.4	-0.8
Lung FEV1/FVC ratio	0.2	1.3	3.4	-1.9	-1.1	-1.8	0.9	0.4	-0.6	-1.4	1.1	0.1	-0.4
Lung FVC	0.3	1.3	5.5	-0.5	-2.3	0.7	-0.8	0.8	1.9	-0.1	-0.5	-0.4	-1.5
Neuroticism	0.4	0.9	3.7	-0.5	-0.7	-0.9	0.3	1.5	0.1	-0.9	0.4	0.7	-1.9
Chronotype (morning person)	1.1	2.6	7.7	-2.8	-0.6	-2.5	-0.5	0.4	-1.1	-2.1	-1.3	1.4	1.4
Hair Pigment	0.0	1.1	3.0	0.4	-1.1	0.9	-1.7	-0.5	1.7	1.5	-0.7	-0.1	-0.5
Tanning	0.1	1.1	5.5	-0.8	-1.0	-0.5	0.5	2.3	0.2	0.3	-0.5	0.0	-1.8
Hand grip strength (left)	0.2	0.5	2.2	0.3	0.4	0.4	0.3	0.3	1.0	1.1	-1.5	-0.3	-0.5
Number of treatments/medications taken	1.0	1.7	8.4	0.6	-0.1	0.8	1.6	-1.1	0.0	-0.8	2.9	-1.0	-1.5
Average weekly spirits intake	2.8	3.4	7.0	-2.0	-2.1	-1.8	-2.0	-0.7	-2.2	-1.6	-1.6	1.3	2.6
Sensitivity / hurt feelings	5.5	9.4	18.7	-3.4	-4.3	-3.4	-3.3	1.2	-2.4	-2.2	-2.2	4.2	2.6
Frequency of depressed mood in last 2 weeks	6.2	8.7	12.6	-3.0	-3.4	-3.2	-3.6	0.4	-1.9	-2.8	-3.5	3.3	3.0
Hearing difficulty/problems: Yes	0.2	0.4	0.9	0.4	-0.3	0.9	-0.3	0.5	1.0	0.2	0.8	-0.0	-0.8
Relative age of first facial hair	0.2	0.4	1.1	-0.3	0.2	-0.6	-0.4	1.1	0.8	-0.4	0.6	1.0	-0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.3	-0.6	0.5	-0.7	-0.8	-1.1	-1.1	-1.0	-0.2	0.8	0.9
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.4	0.5	1.2	0.6	1.1	-1.6	-0.3	-0.7	1.6	-0.9	-0.1
Ever had hysterectomy (womb removed)	1.4	1.6	3.8	1.3	2.0	0.9	0.4	-0.2	1.6	1.0	1.5	-1.1	-1.5
Systolic blood pressure, automated reading	9.0	26.1	56.9	5.7	7.5	5.8	4.9	-1.7	4.1	3.7	5.3	-5.5	-4.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	-0.1	0.1	-0.3	0.7	-0.4	-0.5	-0.0	0.8	0.0	-0.5
Angina	0.3	0.4	1.3	0.3	0.1	0.4	1.1	0.0	0.7	0.4	0.2	-1.1	-1.0
Medication for hormone replacement therapy	0.6	0.7	3.0	0.6	1.7	0.7	0.2	-1.5	-0.1	0.2	0.4	-0.6	0.6
Vitamin and mineral supplements	1.8	2.4	5.8	-1.3	-1.5	-1.7	-2.4	1.1	0.5	0.5	-2.0	1.9	1.5
Supplements: Zinc	1.7	1.9	4.0	1.1	1.9	1.3	1.9	-0.7	-0.2	-0.3	2.0	-1.8	-0.8
Medication: Co-codamol	0.7	0.9	2.9	0.2	0.6	-0.2	0.3	0.7	1.6	1.1	0.3	0.9	-1.7
Medication: Metformin	1.4	2.0	5.5	1.4	2.4	1.3	1.6	-1.2	0.6	0.8	1.1	-1.9	-0.6
Diabetes (father)	4.0	5.0	11.9	2.4	1.2	2.3	2.7	-0.0	1.0	1.7	3.5	-1.7	-3.4
Diabetes (mother)	0.5	0.7	1.8	0.4	0.8	1.2	-0.2	-1.3	-0.2	0.2	1.1	-1.2	-0.0
Severe depression (siblings)	1.1	1.2	3.2	1.1	1.4	1.1	0.5	0.7	0.6	1.2	1.6	-0.5	-1.8
Pack years adult smoking proportion	1.4	2.1	5.8	1.4	2.3	1.4	1.3	-2.0	-0.1	-0.3	0.4	-2.4	0.3
Impedance of leg (right)	8.5	41.1	71.1	-8.2	-8.4	-7.8	-5.0	2.5	-6.2	-5.9	-4.7	7.1	5.9
Leg fat-free mass (left)	3.1	16.5	29.7	5.4	5.4	4.7	3.2	-2.2	3.8	4.1	3.2	-4.2	-3.1
Trunk fat percentage	0.6	2.2	6.7	1.5	2.6	0.7	1.1	-2.2	-0.6	-0.2	2.3	-0.9	-0.0
Hand grip strength (right)	0.3	0.9	2.8	0.2	1.0	0.3	-0.2	0.8	1.7	1.1	-1.5	0.3	-0.7
Townsend deprivation index at recruitment	0.4	0.5	1.8	0.4	0.8	0.5	-1.1	0.1	1.3	0.7	0.2	0.5	-0.7
Current tobacco smoking	6.3	10.3	21.2	4.4	3.6	4.5	2.2	-3.2	2.2	1.8	2.2	-4.6	-1.3
Average weekly fortified wine intake	4.8	5.6	12.1	-2.9	-3.5	-2.5	-2.1	2.1	-2.0	-1.4	-0.5	3.3	1.6
Maternal smoking around birth	0.9	1.4	2.5	-1.1	-0.7	-1.1	-1.1	-0.7	-1.6	-1.4	-1.0	1.2	1.5
Fed-up feelings	6.1	11.2	25.7	-3.8	-5.1	-3.3	-2.9	1.7	-2.1	-2.6	-4.2	3.4	3.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	4.6	-1.7	-1.5	-1.7	-1.4	0.3	-1.4	-1.9	-2.0	2.1	1.5
Relative age voice broke	0.7	1.0	4.9	-1.1	-1.0	-1.2	-0.6	0.8	0.2	-2.2	-0.5	0.7	0.3
Taking other prescription medications	0.1	0.1	0.4	-0.2	-0.0	-0.5	-0.7	-0.3	-0.5	-0.1	0.1	0.3	0.6
Age when periods started (menarche)	2.5	6.0	9.4	-2.5	-2.3	-3.1	-2.9	-0.0	-1.7	-1.6	-2.8	2.9	3.0
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	4.6	-2.2	-0.5	-2.1	-0.9	1.1	-0.4	-1.3	-0.2	1.5	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	17.3	39.2	74.8	8.1	8.7	7.3	4.4	-2.5	5.8	5.1	5.7	-6.4	-6.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	2.5	1.6	1.5	1.2	1.0	-0.3	1.3	1.0	0.3	-1.1	-1.0
Qualifications: CSEs or equivalent	0.3	0.3	1.5	0.1	-0.9	-0.0	-0.7	-0.4	-0.6	0.3	-0.3	-0.1	1.2
Serious illness, injury or assault to yourself	2.7	3.3	9.4	-1.7	-1.1	-1.7	-1.2	-0.7	-3.0	-3.1	-0.9	1.1	1.9
High blood pressure	8.1	22.5	50.6	5.5	7.1	5.1	4.7	-2.0	3.3	2.7	5.0	-5.5	-4.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.1	0.5	1.6	-0.4	0.5	0.4	-0.6	0.4	1.8	-0.5	-0.3
Multivitamins +/- minerals	0.7	0.9	1.7	0.8	1.3	1.2	0.8	-1.1	0.2	0.3	1.3	-0.8	-1.1
Stomach or abdominal pain in last month	4.3	5.4	9.2	-2.7	-3.0	-2.3	-1.7	-0.1	-2.1	-2.5	-2.5	2.6	2.4
Supplements: Glucosamine	0.4	0.5	2.1	0.3	0.7	0.6	1.4	-0.4	-0.5	0.0	0.9	-1.0	0.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.1	-0.1	0.4	-0.3	0.2	-1.3	-0.3	-0.7	-0.2	0.2	1.5
Medication: Atenolol	2.8	3.5	8.6	1.4	2.4	1.9	2.2	-2.5	0.1	0.3	1.6	-2.9	-0.6
Medication: Levothyroxine sodium	5.0	8.5	16.1	-3.6	-4.0	-2.9	-2.7	0.4	-2.7	-1.3	-3.2	2.6	3.8
Sitting height	1.3	9.2	16.4	3.8	3.5	2.7	2.8	1.0	3.3	3.5	2.0	-2.3	-4.0
Chronic bronchitis/emphysema (father)	0.8	0.9	3.3	-0.3	1.2	-0.2	-1.0	-1.4	0.0	-0.3	-1.1	0.1	1.8
High blood pressure (mother)	2.4	3.3	8.2	1.7	2.1	2.0	1.1	-0.0	2.9	1.7	1.5	-1.1	-2.5
Body mass index (BMI)	6.3	26.7	54.0	6.6	7.3	6.0	4.9	-4.2	3.3	3.0	4.9	-6.2	-3.2
Impedance of leg (left)	9.5	46.0	79.0	-8.7	-8.9	-8.4	-5.5	2.8	-6.6	-6.1	-5.1	7.5	6.0
Leg predicted mass (left)	3.1	16.4	29.8	5.4	5.5	4.7	3.2	-2.2	3.8	4.1	3.2	-4.1	-3.1
Trunk fat mass	1.1	4.7	13.0	2.8	3.6	1.9	1.8	-2.4	0.6	0.9	2.7	-2.0	-0.8
Waist circumference	0.8	3.0	5.6	2.0	2.1	1.6	1.9	-2.2	-0.2	0.1	2.4	-2.1	-0.0
Number of incorrect matches in round	0.2	0.3	1.2	-0.5	-0.9	0.1	-1.1	-0.0	-0.1	-0.9	-0.1	0.1	0.3
Past tobacco smoking	1.8	3.4	8.2	-1.5	-2.2	-1.8	-2.6	2.3	0.6	0.9	-1.3	2.9	-0.1
Alcohol usually taken with meals	1.4	2.2	5.5	2.3	1.9	1.5	1.7	0.5	0.8	0.8	1.4	-1.3	-1.5
Nervous feelings	10.1	18.8	38.9	-5.7	-6.2	-5.4	-3.3	2.4	-3.8	-3.4	-2.9	4.9	3.5
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.7	7.2	-2.0	-1.8	-2.2	-2.7	-0.2	-1.1	-1.9	-2.0	2.2	2.0
Hearing difficulty/problems with background noise	0.7	1.0	2.5	-1.3	-1.6	-0.8	-1.2	0.1	-0.9	-1.1	-0.3	1.2	0.8
Hair/balding pattern: Pattern 2	1.4	1.8	5.2	-0.0	0.0	0.5	1.2	-2.3	-2.0	-2.1	0.1	-1.0	1.1
Had menopause	1.8	2.2	3.9	1.8	1.7	1.7	1.3	-1.5	0.4	1.7	2.0	-1.7	-0.2
Had other major operations	1.3	1.6	4.5	1.6	1.3	1.5	1.2	-1.5	0.4	0.3	1.0	-2.1	0.4
Forced vital capacity (FVC)	1.6	6.1	15.0	-2.9	-3.9	-2.6	-2.0	2.2	-0.9	-1.4	-3.3	2.6	0.9
Heel bone mineral density (BMD) T-score, automated (right)	16.0	36.6	76.9	7.8	8.8	7.4	4.4	-3.0	5.1	4.2	5.3	-6.5	-5.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.8	0.2	-0.4	0.0	-0.2	0.4	-0.4	0.2	1.4	0.3	-0.5
Qualifications: None of the above	1.3	2.7	7.2	1.5	1.2	1.9	2.0	-2.7	0.3	0.5	1.7	-2.2	0.8
Financial difficulties in last 2 years	0.5	0.7	1.3	1.2	0.8	0.9	0.6	0.3	1.1	1.1	-0.3	-0.6	-0.8
Mouth/teeth dental problems	2.2	3.3	7.2	-2.3	-2.5	-1.6	-1.3	1.9	-0.6	0.0	-2.7	2.2	1.2
Heart attack	0.1	0.2	0.6	-0.1	-0.5	-0.2	0.1	0.6	-0.2	0.4	-0.8	0.4	0.0
Allergy	1.0	2.3	7.1	-2.0	-2.3	-1.1	-0.9	0.7	-0.2	-1.0	-2.7	1.3	1.2
Pain all over the body in last month	0.5	0.6	2.8	0.3	1.7	-0.2	0.3	-0.4	1.1	0.6	0.5	-0.6	-0.5
Diabetes (self-reported)	0.7	1.0	3.6	0.5	1.6	0.6	1.9	-0.9	-0.2	-0.2	0.6	-1.2	-0.8
Hayfever/allergic rhinitis (self-reported)	1.8	2.3	4.3	-1.8	-2.0	-1.7	-1.7	2.1	-0.1	0.0	-1.2	2.1	-0.4
Medication: Ramipril	4.2	5.3	11.6	2.7	2.4	2.9	1.4	-2.1	2.0	1.7	2.3	-3.4	-1.4
Medication: Simvastatin	0.6	0.9	2.6	0.6	0.7	0.1	1.6	0.4	-0.1	-0.6	1.5	-0.8	-1.5
Fluid intelligence score	2.7	5.6	8.1	-2.3	-2.6	-2.6	-2.7	0.1	-2.7	-1.9	-1.9	2.9	2.7
Illnesses of siblings	0.7	0.9	2.1	-0.6	-1.5	-0.7	-1.3	-0.6	-0.5	-0.5	-1.3	0.6	1.3
Neuroticism score	13.6	28.4	63.2	-6.6	-8.0	-6.2	-4.8	3.9	-3.5	-3.7	-4.7	6.6	3.2
Weight	2.6	12.7	26.2	4.8	5.1	4.0	3.2	-2.3	2.7	2.9	3.2	-3.8	-2.3
Impedance of arm (right)	9.4	43.8	71.9	-8.5	-8.0	-8.3	-5.5	4.1	-5.5	-5.8	-5.4	8.5	4.7
Arm fat percentage (right)	2.3	9.0	23.0	3.6	4.8	3.1	3.2	-2.9	1.2	0.6	3.2	-3.3	-1.5
Trunk fat-free mass	1.7	10.0	17.3	4.2	3.7	3.8	2.6	-1.0	3.3	3.5	2.3	-3.4	-2.5
Hip circumference	2.5	10.8	23.4	4.4	4.8	3.5	3.2	-2.0	2.2	2.5	3.3	-3.2	-2.4
Time employed in main current job	2.2	2.6	9.4	-1.9	-3.1	-1.5	-0.6	0.5	-1.9	-1.9	-0.3	1.4	0.7
Alcohol intake versus 10 years previously	0.5	0.7	2.3	-0.7	-0.6	-0.8	-1.5	0.7	-0.0	0.6	-1.1	1.4	0.0
Father’s age at death	3.2	4.3	10.1	-3.2	-2.7	-2.6	-0.9	2.6	-1.3	-0.7	-1.5	2.5	0.9
Worrier / anxious feelings	14.6	27.6	55.2	-6.4	-7.4	-6.2	-4.8	3.6	-3.2	-3.7	-4.3	6.6	4.4
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	5.5	-2.3	-2.0	-1.9	-1.7	-0.1	-1.6	-2.4	-1.7	2.2	1.4
Falls in the last year	0.2	0.3	1.2	0.4	1.1	0.4	0.6	-0.5	0.5	-0.2	-0.8	-0.1	-0.3
Hair/balding pattern: Pattern 3	0.7	1.1	3.1	0.8	-0.3	0.9	1.2	-1.0	-0.3	1.0	1.8	-1.4	-0.8
Number of live births	0.4	0.6	1.6	0.7	0.4	0.6	-0.8	-0.9	1.0	0.6	1.2	0.2	-0.7
Forced expiratory volume in 1-second (FEV1)	3.6	12.2	26.9	-4.4	-5.2	-4.0	-3.1	2.7	-1.5	-1.8	-4.2	3.8	2.1
Pulse rate	1.5	2.5	8.6	-0.1	-1.5	-0.5	-1.4	-1.3	-1.9	-1.6	-2.0	0.3	2.9
Happiness	0.2	0.3	1.2	-0.0	-0.4	-0.4	0.9	1.1	-0.1	-0.2	-0.6	0.0	-0.5
Noisy workplace	0.2	0.2	0.6	0.2	-0.6	0.3	-0.1	-0.5	0.7	-0.0	0.8	-0.0	-0.5
Qualifications: A levels/AS levels or equivalent	2.8	6.3	10.6	-3.2	-2.7	-2.8	-1.6	0.5	-3.0	-2.2	-2.8	1.9	3.0
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	5.6	-2.1	-1.9	-2.2	-1.1	0.7	-1.1	-1.7	-2.4	1.8	2.1
Mouth/teeth dental problems: Dentures	3.8	6.4	15.2	3.1	3.9	2.3	1.0	-0.7	2.9	2.4	2.9	-1.8	-2.5
Asthma	0.8	1.6	5.1	1.8	1.9	1.1	0.2	-1.3	-0.3	0.3	2.3	-0.2	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	8.5	-1.3	-1.7	-1.2	0.5	-0.8	-2.9	-2.2	0.2	0.7	1.7
Medication: Cholesterol lowering	0.3	0.5	1.4	-0.6	0.7	-1.2	0.7	0.3	-0.6	-1.1	0.2	0.0	-0.4
Depression (self-reported)	1.4	1.6	5.9	-0.7	-1.1	-0.9	-2.4	-0.3	-0.2	-0.3	-2.2	1.2	1.3
Medication: Lansoprazole	0.5	0.6	1.4	-0.6	-0.9	-0.8	-0.5	0.7	-0.6	-0.9	-0.9	1.2	0.1
Prospective memory result	0.8	1.0	2.1	1.1	1.4	0.8	1.0	0.8	1.0	1.4	0.3	-0.8	-0.9
Lung cancer (father)	0.9	1.0	3.6	-0.1	0.2	0.6	0.9	-1.9	-0.9	-1.2	1.3	-1.0	0.5
Illnesses of mother	0.3	0.4	1.1	0.3	0.3	-0.5	-0.9	-0.8	-0.8	0.2	0.4	0.1	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.9	9.3	23.5	-3.7	-4.8	-3.3	-2.8	2.8	-0.5	-1.2	-3.5	3.7	1.0
Pulse wave Arterial Stiffness index	1.3	1.6	6.3	1.0	-0.4	0.8	2.5	1.3	0.5	-0.5	1.1	-0.9	-1.8
Impedance of arm (left)	9.2	42.6	72.1	-8.4	-7.5	-8.3	-5.8	4.1	-5.4	-5.5	-5.5	8.5	4.4
Arm fat mass (right)	3.5	14.5	30.6	4.8	5.5	4.2	3.9	-3.3	1.8	1.7	4.0	-4.4	-2.2
Trunk predicted mass	1.7	9.7	16.9	4.1	3.7	3.8	2.6	-1.0	3.2	3.4	2.3	-3.3	-2.5
Standing height	1.1	11.0	21.9	-3.5	-4.4	-4.1	-3.2	3.8	-1.2	-0.1	-3.2	4.7	1.7
Length of working week for main job	0.9	0.9	3.4	-0.2	0.6	-0.7	1.2	0.5	-1.3	-1.9	1.1	-0.3	-0.7
Exposure to tobacco smoke at home	0.3	0.3	0.9	0.4	0.5	0.4	0.2	0.3	0.5	0.5	0.9	0.2	-0.9
Breastfed as a baby	0.3	0.4	0.9	-0.9	-0.8	-0.6	0.4	-0.1	-0.9	-0.7	-0.4	0.4	0.7
Tense / ‘highly strung’	7.5	12.5	22.4	-4.3	-4.7	-4.4	-3.5	2.1	-2.9	-2.0	-2.5	4.7	2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	6.2	-1.8	-2.2	-1.8	-2.5	0.2	-0.1	-0.7	-1.9	2.4	1.1
Hair/balding pattern: Pattern 4	0.5	1.1	4.2	-0.9	-2.1	-1.1	-1.0	1.0	0.1	-1.1	-0.8	1.1	0.5
Birth weight of first child	3.7	6.8	17.4	-2.9	-1.9	-2.5	-3.1	-0.9	-2.7	-2.2	-2.6	1.5	4.2
Peak expiratory flow (PEF)	4.6	10.8	23.0	-4.0	-4.8	-3.7	-3.4	1.8	-2.1	-1.3	-3.0	3.8	3.2
Pulse wave reflection index	1.4	1.8	5.5	1.0	0.6	1.2	2.3	0.5	1.1	-0.1	1.4	-1.4	-2.1
Ever highly irritable/argumentative for 2 days	1.4	1.7	5.6	-0.9	-0.2	-1.0	0.1	-0.9	-1.8	-2.4	0.3	0.4	2.2
Loud music exposure frequency	1.4	1.5	3.2	1.3	1.3	1.6	-0.4	-1.1	1.7	1.8	0.5	-0.8	-0.7
Qualifications: O levels/GCSEs or equivalent	4.0	6.4	10.8	-3.3	-3.0	-3.2	-1.9	2.2	-1.5	-2.4	-2.4	3.1	1.5
Mouth/teeth dental problems: Bleeding gums	2.8	3.6	6.8	2.6	1.9	1.9	2.1	-1.1	1.0	0.3	2.3	-2.1	-2.2
Blood clot in the leg (DVT)	2.9	3.8	7.9	2.8	2.1	2.4	1.7	-2.2	0.7	0.1	2.0	-2.8	-0.5
Medication: Paracetamol	0.7	1.2	6.1	-1.2	-2.5	-0.6	0.2	-0.4	-0.7	-1.5	0.4	0.8	0.6
Headache pain in last month	2.0	3.4	8.4	-1.4	-2.9	-1.4	-0.7	-0.9	-2.0	-2.4	-1.8	1.0	2.6
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	6.1	-0.7	-2.1	-0.6	-2.5	0.2	-0.5	0.3	-1.6	2.0	1.9
Glaucoma (self-reported)	0.8	1.0	2.2	1.4	1.5	1.5	0.3	-0.5	0.6	1.2	0.3	-1.0	-0.6
Gout (self-reported)	0.2	0.2	0.3	-0.6	0.5	-0.6	0.5	0.5	0.3	0.4	0.5	0.3	-0.3
Hypothyroidism/myxoedema (self-reported)	5.9	11.5	21.8	-4.4	-4.7	-3.6	-3.0	1.0	-2.9	-1.6	-3.3	3.4	4.1
Medication: Amlodipine	3.3	4.7	8.6	2.0	2.2	2.5	0.7	-1.0	2.5	2.9	2.7	-2.1	-1.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.4	0.3	0.1	0.0	1.2	0.6	-0.5	-0.2	1.1	-0.2	-0.7
Birth weight	0.4	0.8	3.3	0.3	1.0	-0.5	-1.8	-0.2	0.1	0.9	-0.9	1.1	1.0
Chronic bronchitis/emphysema (mother)	2.7	3.1	13.2	-1.6	-1.0	-1.5	0.4	-1.0	-3.6	-2.4	0.7	0.4	2.2
High blood pressure (siblings)	0.8	1.1	2.7	1.0	1.7	1.0	0.7	0.3	1.4	1.1	1.2	-0.6	-1.0
Forced vital capacity (FVC), Best measure	1.4	4.9	13.7	-2.3	-3.7	-2.1	-1.5	2.8	0.1	-0.9	-2.8	2.7	-0.5
Body fat percentage	1.2	4.6	11.7	2.4	3.4	1.7	2.0	-2.8	0.1	0.2	2.8	-2.1	-0.5
Leg fat percentage (right)	2.2	8.0	15.9	3.4	3.9	2.8	2.8	-4.0	0.5	0.4	3.1	-3.5	-0.0
Arm fat-free mass (right)	2.7	13.6	24.7	5.0	4.5	4.4	3.2	-2.0	2.9	3.6	3.3	-4.3	-2.6
Exposure to tobacco smoke outside home	0.6	0.8	2.3	-1.0	-1.0	-1.2	-1.1	-0.1	-0.0	-0.8	-0.3	1.5	0.5
Comparative body size at age 10	6.9	19.2	33.3	5.8	5.2	5.7	2.8	-2.2	4.2	3.4	4.0	-4.5	-4.5
Number of full brothers	2.2	2.8	8.6	2.0	1.6	2.3	1.0	-2.9	0.4	0.5	1.1	-2.2	-0.1
Worry too long after embarrassment	7.9	13.2	28.2	-4.5	-5.3	-4.5	-2.5	3.3	-2.2	-2.8	-3.5	4.3	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	-0.1	-0.4	-0.2	-1.1	-0.4	-0.2	-0.1	-1.1	1.1	0.0
Wheeze or whistling in the chest in last year	2.7	4.8	9.2	3.0	2.7	2.4	1.8	-1.6	2.0	0.6	2.7	-2.3	-1.6
Number of children fathered	1.7	1.9	4.8	1.1	0.4	1.3	2.1	-0.6	1.1	-0.1	1.5	-1.8	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	5.1	-2.1	-1.6	-2.3	-0.6	1.5	-0.5	-1.1	-1.0	1.7	0.5
Age at first live birth	3.5	6.2	15.5	-2.7	-2.6	-3.0	-2.8	1.5	-1.2	-0.2	-3.9	2.5	2.3
Pulse wave peak to peak time	2.0	2.3	8.5	-1.4	0.0	-1.3	-2.9	-1.1	-0.8	0.3	-1.5	1.4	2.2
Health satisfaction	1.1	1.4	5.2	1.1	1.3	0.4	2.3	-0.2	-0.4	-1.0	1.3	-1.6	-0.6
Shortness of breath walking on level ground	0.9	1.1	6.9	0.6	0.3	0.2	1.4	-0.7	-0.5	0.4	2.6	-0.5	-0.5
Qualifications: College or University degree	0.7	2.3	4.3	-1.7	-1.3	-1.8	-1.1	0.9	-1.7	-1.3	-2.1	1.2	1.7
Eye problems/disorders: None of the above	0.5	0.5	2.2	0.8	0.4	0.7	-0.5	-1.5	0.7	0.5	0.6	-0.6	0.6
Mouth/teeth dental problems: Loose teeth	4.0	4.8	8.2	2.8	1.8	2.9	2.1	-2.8	0.9	-0.2	2.7	-2.9	-0.8
Emphysema/chronic bronchitis	4.6	5.1	14.5	2.7	3.8	2.2	2.7	-1.4	1.5	0.7	1.4	-3.0	-1.5
Medication for pain relief, constipation, heartburn	0.7	1.2	2.9	0.8	1.7	0.6	-0.9	1.6	1.4	1.3	-1.0	0.1	-0.6
Neck or shoulder pain in last month	0.7	1.0	6.0	0.8	-0.5	1.4	0.0	-2.4	-0.1	0.1	0.4	-0.7	0.9
Medication: Blood pressure	3.9	6.9	11.8	2.5	3.2	2.7	3.3	-1.2	1.7	0.8	3.0	-3.4	-2.9
Angina (self-reported)	0.5	0.7	2.0	0.6	0.4	0.7	1.4	-0.4	0.8	0.4	0.3	-1.4	-0.9
Migraine (self-reported)	0.2	0.3	1.4	0.2	-1.2	-0.1	0.7	0.7	-0.4	-0.2	0.2	0.4	-0.5
Medication: Ibuprofen	1.3	1.6	4.9	-0.6	-1.9	-0.3	0.1	-1.6	-2.2	-1.6	0.8	0.5	1.0
Medication: Allopurinol	0.8	1.0	2.1	0.9	1.4	1.0	1.4	-0.7	0.7	0.8	1.0	-1.1	-0.7
Medication: Omeprazole	0.6	0.8	2.4	0.6	0.1	0.7	0.1	-1.2	1.2	1.6	0.7	-0.8	0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.8	0.5	0.1	0.2	-0.0	0.0	-0.3	-0.4	0.9	-0.4	0.0
Mean time to correctly identify matches	0.1	0.2	0.5	0.4	0.2	0.7	0.2	-0.1	0.2	0.5	-0.2	-0.1	-0.6
Heart disease (mother)	0.6	0.8	3.6	0.0	-1.0	0.4	1.9	0.8	0.8	-0.3	-0.4	-0.6	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.3	3.9	8.4	-2.0	-2.4	-1.5	-2.0	-0.9	-2.5	-1.5	-2.0	1.4	2.9
Whole body fat mass	2.0	8.3	19.1	3.7	4.4	3.0	2.7	-3.1	1.1	1.3	3.2	-3.2	-1.2
Leg fat mass (right)	3.6	14.0	26.0	4.9	5.1	4.2	3.5	-4.0	1.9	1.9	3.8	-4.5	-1.4
Arm predicted mass (right)	3.1	15.8	28.1	5.3	4.6	4.7	3.6	-1.9	3.2	4.1	3.6	-4.6	-3.0
Pulse rate, automated reading	0.4	1.3	2.6	1.0	-0.2	-0.2	-1.4	-1.3	-1.6	-1.3	-0.9	0.4	1.6
Alcohol intake frequency.	0.4	0.9	1.9	1.3	0.0	1.4	0.7	-0.9	0.9	0.2	1.1	-0.5	-1.1
Comparative height size at age 10	0.9	5.0	14.7	2.5	0.9	2.3	0.3	1.4	3.2	3.8	1.4	-1.0	-2.8
Number of full sisters	2.4	2.9	5.2	2.3	1.7	2.0	1.7	-1.3	1.6	2.0	1.5	-1.6	-0.9
Suffer from ‘nerves’	6.2	9.7	21.1	-3.6	-4.6	-3.4	-3.0	0.9	-3.0	-1.5	-2.7	3.8	2.9
Overall health rating	2.1	4.6	12.2	2.7	3.5	2.2	2.2	-2.4	0.3	0.2	1.9	-2.4	-1.3
Chest pain or discomfort	0.7	1.0	3.0	-1.1	-1.7	-1.0	-0.3	0.2	-0.4	-1.1	-1.5	0.6	0.6
Had major operations	0.4	0.5	1.5	0.4	-0.9	0.4	0.7	-0.4	-0.5	-0.8	1.2	-0.5	-0.5
Age at last live birth	6.5	9.4	16.2	-3.4	-2.7	-3.8	-4.0	2.1	-1.7	-0.9	-4.0	3.8	2.4
Family relationship satisfaction	0.6	0.8	1.8	-0.8	-0.4	-1.3	0.5	0.8	-0.9	-0.5	-1.4	0.4	1.2
Leg pain on walking	2.8	3.5	7.1	2.3	1.7	1.9	2.7	-0.1	0.7	1.2	2.4	-1.9	-2.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.0	-0.4	0.5	-1.0	-0.5	0.6	-1.4	-0.0	-0.2	0.8	0.6
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.8	0.9	0.9	0.7	-0.5	-0.9	0.8	1.4	0.4	-0.3	-0.4
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.6	1.3	1.9	1.5	0.2	-1.1	1.4	1.6	0.8	-1.2	-0.2
Medication: Aspirin	1.6	2.1	4.2	1.6	2.1	1.1	1.5	-0.8	0.7	1.3	2.0	-1.6	-1.4
Supplements: Vitamin C	4.1	4.8	15.1	2.0	1.4	2.6	3.4	-1.4	0.0	-1.2	1.8	-3.9	-1.4
Knee pain experienced in last month	0.4	0.6	1.2	0.9	1.1	0.7	0.6	-0.8	0.7	0.8	0.7	-0.3	-1.0
Hypertension (Self-reported)	7.8	21.6	47.7	5.4	6.9	5.0	4.9	-2.1	2.8	2.3	5.2	-5.5	-4.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	2.5	0.5	-0.3	0.4	-0.3	-1.6	0.5	-0.1	0.5	-0.1	0.2
Illnesses of father: Heart disease	0.4	0.5	1.6	0.1	0.0	-0.3	-0.6	1.1	0.6	0.1	0.7	0.9	-1.2
Illnesses of siblings: Diabetes	1.2	1.4	3.3	0.8	1.3	0.8	1.8	0.0	-0.4	-0.1	1.8	-1.1	-1.8
Smoking status: Previous	1.1	1.6	4.6	0.1	0.8	0.4	2.1	-1.4	-1.5	-1.7	0.7	-1.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	5.2	-1.5	-1.3	-1.4	-0.5	1.1	-0.0	-0.7	-2.3	1.1	0.4
Whole body fat-free mass	2.4	13.7	24.0	4.9	4.7	4.4	3.0	-1.6	3.5	3.9	2.9	-3.9	-2.9
Leg fat-free mass (right)	2.9	15.7	28.2	5.3	5.2	4.6	3.0	-1.8	3.7	4.1	3.1	-4.0	-3.3
Arm fat percentage (left)	2.5	9.8	26.1	3.9	5.1	3.3	3.1	-2.8	1.5	1.0	3.2	-3.4	-1.7
Average weekly red wine intake	0.3	0.4	1.0	1.0	0.5	0.7	0.9	0.4	0.6	0.2	-0.2	-0.4	-0.7
Handedness (chirality/laterality): Left-handed	0.8	0.9	4.6	0.1	0.5	0.8	-0.6	-2.1	-0.7	-0.3	0.1	-1.0	1.3
Mood swings	5.7	10.2	17.0	-3.4	-4.1	-3.3	-3.7	0.9	-2.3	-2.1	-3.6	3.0	4.0
Loneliness, isolation	1.3	1.8	3.8	-1.6	-1.9	-1.4	-1.6	0.7	-0.7	-1.2	-1.3	1.7	0.2
Long-standing illness, disability or infirmity	0.5	0.7	2.1	0.9	0.8	0.7	1.2	0.1	0.1	0.3	1.5	-0.7	-0.9
Ever had bowel cancer screening	0.8	0.9	3.0	-1.1	-1.0	-0.9	-0.9	1.3	-0.3	1.7	0.3	0.5	0.0
Diabetes diagnosed by doctor	0.9	1.4	4.7	0.9	2.2	0.5	1.7	-0.3	0.6	0.9	1.0	-1.1	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.7	7.3	1.9	2.5	1.7	1.3	-2.7	-0.0	-0.6	0.4	-2.3	-0.1
Friendships satisfaction	0.5	0.7	2.4	0.5	0.1	0.6	1.6	-0.9	-1.0	-0.2	-0.0	-1.4	-0.1
Qualifications: nursing, teaching	1.2	1.8	3.9	-1.8	-1.2	-2.0	-1.3	0.8	-1.4	-1.0	-0.9	1.7	0.6
Commuting to job workplace: Walk	0.4	0.4	2.5	-0.2	-0.1	-0.3	0.4	-0.8	-0.6	-1.6	-0.1	-0.0	0.4
Eye problems/disorders: Cataract	1.4	1.6	4.4	-1.5	-1.3	-1.6	-0.8	1.4	-0.9	-0.7	-1.1	2.1	0.5
Mouth/teeth dental problems: Mouth ulcers	2.5	3.9	9.1	-1.5	-2.4	-1.4	-1.7	-1.5	-3.0	-2.2	-1.3	0.8	2.7
Medication for cholesterol	3.5	5.4	9.3	-2.7	-2.9	-2.8	-2.4	1.6	-0.5	-1.0	-3.0	3.0	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	7.0	0.1	-0.4	0.5	1.1	-2.7	-0.9	-0.6	1.4	-1.2	0.4
Back pain experienced in last month	0.4	0.6	2.5	0.9	0.6	0.8	0.2	-1.6	-0.3	-0.9	0.9	-0.5	0.4
Mineral and other dietary supplements	3.5	4.6	10.2	-2.0	-3.1	-2.1	-2.5	0.2	-1.0	-1.0	-3.2	1.7	2.7
Breast cancer (self-reported)	0.2	0.2	0.7	0.2	-0.3	0.3	-0.1	-0.5	-0.8	-0.7	0.8	-0.1	-0.2
Asthma (self-reported)	0.9	1.8	5.7	1.8	2.1	1.2	0.7	-1.2	-0.1	0.3	2.4	-0.4	-1.0
Osteoporosis (self-reported)	2.7	3.3	6.8	-2.2	-2.2	-2.3	-1.5	0.9	-1.7	-1.1	-1.5	2.6	1.2
Osteoarthritis (self-reported)	1.6	2.1	7.1	0.8	0.8	1.2	1.7	-2.7	-1.0	-1.3	1.3	-1.9	0.3
Medication: Aspirin	1.8	2.3	4.3	1.7	1.7	1.3	1.8	-0.5	0.7	1.0	2.1	-1.6	-2.0
Medication: Gliclazide	1.6	1.8	3.2	1.5	1.7	1.5	1.8	-0.5	1.4	0.9	0.8	-1.6	-1.1
Illnesses of father: None of the above (group 1)	1.2	1.4	3.8	-1.5	-1.1	-1.1	-0.5	0.6	-1.4	-1.1	-1.9	0.3	1.5
Smoking status: Current	6.3	10.0	19.2	4.4	3.7	4.3	2.4	-2.7	2.5	1.8	2.1	-4.4	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.9	8.3	23.3	-3.3	-4.8	-2.9	-3.6	1.9	-0.6	-0.6	-3.3	3.0	1.7
Whole body water mass	2.3	13.3	23.4	4.8	4.6	4.4	3.0	-1.5	3.5	3.9	2.8	-3.9	-2.9
Leg predicted mass (right)	2.9	15.3	27.7	5.2	5.3	4.6	3.1	-1.7	3.6	4.0	3.1	-4.0	-3.2
Arm fat mass (left)	3.3	13.7	29.8	4.8	5.5	4.1	3.6	-3.1	2.2	1.9	3.7	-4.2	-2.2
Number of self-reported non-cancer illnesses	0.2	0.4	1.3	0.0	0.6	0.0	0.6	-0.5	-1.1	-0.7	1.0	-0.5	-0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.7	0.1	0.3	0.1	0.5	-0.1	-0.9	-0.6	-0.2	-0.2	0.5
Miserableness	7.7	13.3	24.7	-4.1	-5.0	-3.9	-3.4	2.8	-2.3	-3.1	-4.2	3.9	3.0
Guilty feelings	9.4	14.2	23.4	-4.7	-4.7	-4.8	-2.6	2.9	-2.0	-3.5	-4.5	4.2	2.3
Wears glasses or contact lenses	2.4	2.7	7.6	-1.6	-2.1	-1.7	-0.7	0.6	-2.4	-2.7	-0.8	1.1	1.1
Ever taken oral contraceptive pill	1.6	1.8	5.7	-0.9	-0.1	-1.0	-0.3	-0.4	-0.5	-2.1	-2.4	0.3	2.3
Hearing aid user	0.2	0.3	1.3	-0.5	-0.7	0.1	0.1	-0.3	-0.2	-0.2	0.6	-0.0	-1.1
Mother’s age at death	0.9	1.2	3.8	-1.1	-1.9	-1.2	-0.4	1.0	-1.4	-0.5	0.1	1.2	0.6
Financial situation satisfaction	1.2	1.5	3.5	1.4	1.1	1.1	1.9	-0.1	1.7	1.0	0.9	-1.3	-1.1
Tinnitus: Yes, now most or all of the time	1.8	2.1	5.5	-1.0	-1.7	-0.6	-1.4	-1.4	-2.3	-1.3	-1.2	0.3	1.9
Commuting to job workplace: Public transport	1.0	1.2	2.6	-1.1	-1.6	-1.2	-1.2	1.3	-0.8	0.5	-0.3	1.4	0.9
Eye problems/disorders: Glaucoma	1.1	1.3	3.8	1.5	2.0	1.6	0.3	-0.6	0.6	1.3	0.2	-1.1	-0.9
Medication: Blood pressure	8.8	16.7	28.5	4.9	5.3	4.6	4.2	-1.0	3.0	2.7	4.5	-4.8	-4.0
Pain type(s) experienced in last month: Hip pain	0.9	1.1	4.8	0.8	-0.1	0.9	1.1	-0.9	-0.5	-0.8	2.2	-0.3	-1.4
Supplements: Fish oil (including cod liver oil)	4.1	5.4	13.9	2.4	2.8	2.4	2.1	-0.2	1.3	1.2	3.7	-1.5	-3.3
High cholesterol (Self-reported)	0.2	0.4	0.8	0.2	0.9	-0.4	0.8	-0.1	-0.6	-0.9	0.7	-0.7	-0.3
Medication: Bendroflumethiazide	8.3	12.6	19.8	4.3	3.8	4.0	4.5	-1.2	2.5	1.4	4.3	-3.5	-4.2
Medication: Paracetamol	0.3	0.5	2.4	-0.5	-1.5	-0.0	-0.4	-0.1	0.6	-0.3	0.8	0.9	-0.4
Medication: Lisinopril	2.4	3.1	8.4	1.7	2.2	1.8	2.9	-1.5	0.3	-0.9	1.2	-2.3	-1.2
Medication: Atorvastatin	0.4	0.5	2.2	-0.5	0.5	-0.5	0.1	-0.5	-1.5	-1.0	1.0	0.1	0.1
Illnesses of father: High blood pressure	2.0	2.5	7.2	2.1	0.9	1.9	0.7	-1.4	1.5	1.3	2.7	-1.0	-1.2
Alcohol drinker status: Never	0.7	0.8	2.8	-0.6	-1.3	-0.2	1.2	-0.7	-0.7	-1.7	0.7	0.2	0.1
Ever smoked	0.9	1.6	5.4	1.0	0.9	1.3	0.9	-2.3	-0.9	-0.5	0.1	-2.0	1.1
Basal metabolic rate	2.5	14.0	24.9	5.0	4.9	4.4	3.1	-1.9	3.4	3.7	3.1	-3.9	-2.9
Leg fat percentage (left)	2.1	7.7	15.0	3.3	3.9	2.8	2.8	-3.7	0.5	0.5	3.1	-3.4	-0.4
Arm fat-free mass (left)	2.9	14.5	26.2	5.1	4.5	4.6	3.5	-2.2	2.8	3.7	3.4	-4.5	-2.6
Number of operations (self-reported)	1.5	2.2	3.7	1.8	1.2	1.9	1.2	-1.6	1.1	0.2	1.9	-1.9	-1.3
Average weekly beer plus cider intake	4.7	6.8	21.6	-3.4	-4.6	-2.6	-1.7	1.1	-2.8	-1.8	-1.2	2.9	1.7
Irritability	14.1	23.9	41.0	-6.1	-6.4	-5.6	-5.3	1.7	-3.1	-3.5	-4.4	6.0	4.7
Risk taking	2.2	3.2	11.4	1.9	3.4	1.5	0.5	-0.5	1.5	1.9	0.9	-2.2	-1.7
Ever had prostate specific antigen (PSA) test	0.9	1.0	3.6	-0.8	0.2	-1.1	-1.9	0.4	0.3	0.3	-1.7	1.0	0.7
Fractured/broken bones in last 5 years	0.3	0.4	1.2	-0.2	-1.1	0.1	1.0	-0.9	-0.1	0.3	0.4	-0.5	0.9
Age started oral contraceptive pill	0.8	0.9	2.5	-1.0	-0.8	-1.0	-1.2	0.3	0.0	0.9	-1.4	0.5	1.6
Diastolic blood pressure, automated reading	10.4	32.1	73.6	7.0	8.6	6.5	5.9	-2.7	4.2	3.4	4.7	-6.7	-4.3
Ever depressed for a whole week	0.6	0.8	2.4	-1.3	-1.6	-0.7	-1.0	0.2	-0.6	-0.6	-0.4	1.2	-0.0
Unable to work because of sickness or disability	2.2	2.8	6.0	2.5	1.6	2.1	0.7	-2.3	2.4	1.0	-0.3	-1.5	-0.3
Commuting to job workplace: Cycle	0.3	0.3	1.0	0.3	-0.2	-0.0	0.5	0.4	-0.6	-0.6	0.8	-0.3	-1.0
Myopia	0.4	0.5	2.2	-0.7	-0.3	-0.9	-0.7	1.5	-0.6	0.1	0.0	0.8	-0.3
Vascular/heart problems diagnosed by doctor	6.8	18.5	39.9	-4.8	-6.3	-4.5	-4.4	1.6	-2.8	-2.6	-4.8	5.2	3.9
Cholesterol lowering medication	0.4	0.6	3.3	0.5	-0.3	0.3	0.8	0.5	-0.6	-0.2	1.8	-0.5	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.0	0.3	-0.5	0.3	0.3	-1.0	0.7	0.9	0.1	-0.8	0.1
Pain experienced in last month	1.0	1.6	8.9	-1.2	-0.9	-1.2	0.1	3.0	-0.2	0.1	-0.3	1.4	-1.1
Supplements: Calcium	0.4	0.4	1.1	0.4	0.6	0.3	1.1	0.4	0.7	0.2	0.7	0.1	-1.0
Basal cell carcinoma (self-reported)	0.3	0.3	1.3	0.2	0.1	0.2	0.7	-0.5	-0.1	-1.2	0.6	-0.9	-0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	0.2	-0.3	0.1	0.3	0.5	-0.1	0.6	-0.5	0.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	3.3	4.2	9.1	3.0	2.1	2.6	1.7	-1.8	1.1	0.5	2.2	-2.8	-1.0
Heart disease (siblings)	0.6	0.7	2.5	-0.6	0.5	-0.6	-0.4	-0.9	-1.2	-0.4	-1.1	-0.0	1.6
Alcohol drinker status: Previous	0.2	0.3	0.6	-0.1	-0.5	-0.1	-0.8	-0.1	0.2	-0.7	-0.8	0.8	-0.3
Pack years of smoking	0.8	1.2	3.7	0.9	1.9	0.9	0.7	-1.5	-0.1	-0.2	0.2	-1.8	0.4
Impedance of whole body	10.1	51.6	83.0	-9.1	-8.8	-9.0	-6.1	3.9	-6.6	-6.2	-5.8	8.6	5.6
Leg fat mass (left)	3.6	13.9	26.0	4.9	5.1	4.1	3.5	-3.9	1.9	2.0	3.9	-4.5	-1.5
Arm predicted mass (left)	3.0	15.0	27.0	5.2	4.6	4.7	3.6	-2.2	2.9	3.5	3.5	-4.5	-2.7