Hub : Genes

NEIL2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1660 0.0500 1.3e-07 0.037 0.071 0.046 0.067 0.059 2.3e-05 5.0e-09 2.2e-06 1.5e-08 1.1e-07
2 GTEx Adipose Subcutaneous 0.1220 0.0420 1.7e-05 0.137 NA 0.136 NA 0.133 2.8e-11 NA 3.3e-11 NA 5.4e-11
3 GTEx Artery Aorta 0.2990 0.0680 1.9e-06 0.141 NA 0.172 NA 0.186 3.5e-08 NA 9.2e-10 NA 1.7e-10
4 GTEx Artery Tibial 0.2129 0.0526 8.8e-08 0.073 NA 0.129 NA 0.119 2.4e-06 NA 2.8e-10 NA 1.4e-09
5 GTEx Breast Mammary Tissue 0.2300 0.0640 3.1e-05 0.031 NA 0.115 NA 0.083 1.0e-02 NA 1.8e-06 NA 4.6e-05
6 GTEx Breast Mammary Tissue (Male) 0.2884 0.1593 7.8e-02 0.003 NA 0.074 NA 0.010 2.7e-01 NA 8.8e-03 NA 1.9e-01
7 GTEx Breast Mammary Tissue (Female) 0.1308 0.0950 8.4e-02 0.019 NA -0.009 NA -0.002 9.0e-02 NA 8.0e-01 NA 3.9e-01
8 GTEx Cells EBV-transformed lymphocytes 0.4470 0.0910 3.8e-05 0.107 NA 0.124 NA 0.131 2.4e-04 NA 7.9e-05 NA 4.8e-05
9 GTEx Cells Transformed fibroblasts 0.2250 0.0500 5.4e-07 0.080 NA 0.137 NA 0.130 1.4e-06 NA 1.9e-10 NA 5.5e-10
10 GTEx Esophagus Mucosa 0.2290 0.0570 1.2e-05 0.049 NA 0.089 NA 0.120 3.3e-04 NA 1.6e-06 NA 2.3e-08
11 GTEx Esophagus Muscularis 0.1790 0.0650 6.7e-04 0.081 NA 0.032 NA 0.044 1.2e-05 NA 4.7e-03 NA 1.1e-03
12 GTEx Heart Atrial Appendage 0.1900 0.0620 2.7e-06 0.199 NA 0.228 NA 0.240 2.6e-09 NA 1.4e-10 NA 4.0e-11
13 GTEx Muscle Skeletal 0.1097 0.0380 7.1e-05 0.078 NA 0.046 NA 0.054 4.0e-08 NA 2.2e-05 NA 4.7e-06
14 GTEx Nerve Tibial 0.3365 0.0627 6.3e-12 0.199 NA 0.217 NA 0.251 4.6e-14 NA 2.5e-15 NA 8.1e-18
15 GTEx Ovary 0.4720 0.1130 3.7e-05 0.320 NA 0.197 NA 0.255 1.3e-08 NA 1.4e-05 NA 5.7e-07
16 GTEx Pancreas 0.3170 0.0940 1.4e-03 0.041 NA 0.007 NA 0.018 7.8e-03 NA 1.6e-01 NA 5.6e-02
17 GTEx Skin Not Sun Exposed Suprapubic 0.2580 0.0670 4.5e-05 0.046 NA 0.086 NA 0.015 1.6e-03 NA 2.0e-05 NA 4.6e-02
18 GTEx Skin Sun Exposed Lower leg 0.2920 0.0490 1.5e-10 0.140 NA 0.209 NA 0.213 1.1e-11 NA 3.4e-17 NA 1.7e-17
19 GTEx Testis 0.2410 0.0830 4.8e-03 0.047 NA -0.005 NA 0.007 3.9e-03 NA 6.7e-01 NA 1.5e-01
20 GTEx Thyroid 0.1390 0.0470 1.7e-05 0.081 NA 0.088 NA 0.079 8.6e-07 NA 2.9e-07 NA 1.2e-06
21 GTEx Whole Blood 0.0940 0.0430 8.7e-04 0.013 NA 0.027 NA 0.022 2.0e-02 NA 1.5e-03 NA 3.9e-03
22 METSIM Adipose 0.0615 0.0241 8.1e-03 0.002 0.010 0.001 0.012 0.008 1.7e-01 9.5e-03 1.8e-01 4.8e-03 1.9e-02
23 NTR Blood 0.0441 0.0139 1.4e-06 0.026 0.020 0.017 0.020 0.020 5.7e-09 3.5e-07 2.2e-06 4.5e-07 3.0e-07
24 ROSMAP Brain Pre-frontal Cortex 0.2074 0.0428 2.3e-12 0.118 0.110 0.150 0.148 0.160 6.8e-15 5.6e-14 9.3e-19 1.5e-18 4.8e-20
25 YFS Blood 0.2350 0.0355 0.0e+00 0.091 0.125 0.129 0.140 0.127 3.1e-28 1.1e-38 4.3e-40 2.2e-43 2.7e-39
26 TCGA Kidney Renal Clear Cell Carcinoma 0.0520 0.0198 5.4e-07 0.067 0.069 0.075 NA 0.074 5.4e-08 3.1e-08 8.1e-09 NA 1.0e-08
27 TCGA Brain Lower Grade Glioma 0.0837 0.0343 3.3e-06 0.080 0.064 0.081 NA 0.079 2.0e-09 8.7e-08 1.7e-09 NA 2.9e-09
28 TCGA Prostate Adenocarcinoma 0.0733 0.0316 5.5e-04 0.024 0.025 0.003 NA 0.002 1.4e-03 1.2e-03 1.5e-01 NA 1.8e-01
29 TCGA Thyroid Carcinoma 0.1390 0.0460 7.9e-09 0.085 0.100 0.079 NA 0.088 1.2e-08 6.3e-10 3.9e-08 NA 7.2e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
Bipolar Disorder (2018) 0.3 0.4 4.0 -0.1 0.1 -0.4 -0.1 -1.2 0.7 -0.5 0.2 -0.4 -1.1 0.4 -0.1 0.2 0.1 -0.1 -0.0 -0.6 -1.1 0.6 -0.3 1.0 -0.6 -0.2 0.9 -0.0 0.2 0.3 -2.0 -0.5
Bipolar Disorder or Schizophrenia 0.7 1.7 11.1 -1.2 0.8 1.2 0.5 -0.1 0.2 -0.7 1.8 1.4 -1.7 0.5 1.4 2.0 1.3 1.4 0.6 -0.6 -2.0 0.7 1.5 1.5 -0.4 0.8 0.6 -0.1 1.5 1.6 -3.3 1.0
Depressed Affect (Nagel 2018) 0.9 1.9 6.1 1.7 -1.2 -2.5 -1.7 -0.6 0.7 -0.8 -1.2 -1.5 0.5 -0.8 -2.0 -1.6 -2.0 -1.9 -2.4 0.0 0.0 -1.2 -1.5 -1.3 -0.1 -1.5 -1.1 -1.3 -1.7 -1.4 0.0 -1.1
Depression (Nagel 2018) 1.8 2.7 6.1 2.5 -1.7 -1.9 -1.6 -1.0 -0.8 0.8 -1.7 -1.0 1.5 -1.9 -2.1 -1.7 -1.6 -1.7 -2.3 1.7 -0.5 -0.9 -2.1 -1.7 -1.5 -1.8 -2.0 -1.2 -2.2 -1.4 1.3 -1.8
Intelligence (Savage-Jansen 2018) 1.2 3.5 8.9 1.8 -2.4 -1.8 -2.0 -1.4 -2.9 1.1 -1.8 -1.7 -0.1 -2.7 -2.1 -1.5 -1.9 -2.0 -2.0 -1.7 -1.6 -0.5 -2.3 -3.0 -2.1 -1.5 -2.1 -0.7 -2.1 -1.4 0.8 -2.1
Neuroticism (Nagel 2018) 0.8 2.0 6.0 1.2 -1.2 -2.5 -1.7 -0.4 1.1 -0.8 -1.3 -1.8 0.6 -0.7 -2.1 -1.9 -1.9 -1.9 -1.8 -0.3 0.5 -1.2 -1.5 -1.0 0.1 -1.9 -1.1 -0.6 -2.1 -1.6 0.2 -1.3
Schizophrenia (2018) 1.0 2.1 7.5 -1.4 0.9 1.8 0.8 0.7 -0.3 -0.5 2.2 2.1 -1.3 0.4 1.9 2.3 1.5 1.8 0.8 -0.3 -1.6 0.4 2.1 1.3 -0.0 1.2 -0.0 -0.1 1.7 1.9 -2.7 1.7
Schizophrenia vs Biploar Disorder 2.2 2.9 5.9 -1.7 2.1 2.4 2.3 2.2 -0.2 1.3 1.8 1.5 0.5 1.4 2.1 2.2 2.1 2.0 1.8 0.8 0.4 1.4 2.1 1.9 0.7 2.0 1.3 1.7 2.1 2.0 0.3 1.7
Worry (Nagel 2018) 0.4 0.9 3.2 0.7 -0.7 -1.2 -0.9 0.2 1.8 -0.1 -0.9 -0.7 1.2 -0.2 -1.0 -1.3 -0.9 -0.9 -0.7 1.2 0.7 -1.1 -0.7 -0.1 -0.1 -1.6 -1.0 -0.4 -1.5 -1.1 0.1 -1.0
Alzheimer’s Disease (in mother) 0.2 0.2 1.2 0.4 -0.2 0.0 -0.1 -0.6 0.1 0.2 -0.9 -0.7 0.5 -0.1 -0.2 -0.1 -0.3 -0.3 0.1 0.4 0.5 -0.2 -0.5 1.1 0.1 0.4 -0.2 0.2 -0.2 -0.6 -0.5 -0.6
Alzheimer’s Disease (in father) 0.2 0.2 1.6 0.8 0.2 -0.1 -0.3 0.3 0.5 -0.9 -0.1 -0.4 -1.3 -0.5 -0.4 0.1 -0.2 0.0 0.1 -0.7 -0.5 0.4 -0.0 -0.2 0.7 0.2 0.3 -0.2 -0.1 0.4 -0.5 0.2
Alzheimer’s Disease (including proxy) 0.3 0.5 1.7 0.9 -0.5 -0.4 -0.9 -0.6 -0.1 -0.8 -1.2 -1.3 -0.3 -0.9 -1.1 -0.3 -0.7 -0.6 -0.2 0.0 -0.0 -0.6 -0.7 0.4 0.3 0.2 -0.4 -0.4 -1.0 -0.8 -0.7 -0.7
Crohns Disease (2017) 0.4 1.0 3.0 -1.4 1.0 0.6 0.8 1.3 1.5 -0.1 1.0 1.0 0.4 1.4 1.1 1.0 0.7 0.7 0.5 1.1 0.5 -0.9 1.5 1.1 0.6 0.6 0.4 0.4 0.9 0.7 -1.7 1.3
Irritable Bowel Disease (IBD) 0.2 0.5 2.6 0.2 0.2 -0.8 -0.4 -0.0 1.5 -1.1 -0.9 -0.9 -0.5 0.5 -0.7 -0.4 -0.6 -0.7 -0.4 0.7 0.7 -0.6 -0.2 0.7 1.6 0.1 0.8 0.3 -0.5 -0.8 -1.0 -0.6
Ulcerative Colitis (UC) 1.0 1.8 5.5 1.1 -0.6 -1.8 -1.4 -1.1 0.8 -1.6 -2.3 -2.3 -1.0 -0.5 -2.0 -1.5 -1.5 -1.6 -1.4 0.5 0.8 -0.4 -1.5 -0.1 1.7 -0.6 0.4 -0.5 -1.6 -1.8 -0.3 -1.9
Major Depression (MDD) 1.1 1.3 3.2 1.2 -1.0 -1.4 -1.4 -1.3 -0.8 -0.7 -1.8 -1.5 0.2 0.0 -0.9 -1.5 -1.2 -1.4 -1.5 0.4 0.3 -1.6 -0.8 0.2 -1.1 -1.2 -0.2 -1.8 -1.1 -1.6 -0.2 -1.2
Reaction Time 0.9 1.8 6.0 1.7 -1.3 -0.9 -1.4 -2.2 -1.0 -2.5 0.0 0.2 -2.0 -1.8 -0.8 -1.4 -1.0 -0.8 -0.8 -1.2 -2.4 -0.5 -0.8 -1.0 -0.0 -1.7 -0.5 -0.2 -0.9 -0.2 -2.3 -1.1
Verbal and Numeric Reasoning (VNR) 1.9 4.5 12.0 2.6 -2.9 -1.9 -2.4 -1.8 -1.7 0.5 -1.7 -1.6 -0.1 -3.5 -2.5 -1.8 -2.1 -2.2 -2.1 -2.0 -1.8 -0.3 -3.0 -3.0 -1.9 -1.8 -2.9 -1.1 -2.4 -1.9 1.2 -2.5
Breast Cancer 0.5 1.3 5.2 -1.7 1.0 1.0 0.9 1.0 -0.8 1.8 1.5 1.3 0.3 0.7 1.4 0.9 1.3 1.2 1.3 0.9 -0.7 0.2 1.5 1.2 -2.3 0.1 0.5 -0.3 1.1 0.9 -0.7 1.2
Ovarian Cancer 0.2 0.3 1.4 0.2 0.4 -0.6 -0.1 -0.3 -0.6 -0.6 1.0 -0.5 0.2 0.6 -0.3 -0.2 -0.6 -0.5 -0.5 -0.3 0.3 0.4 -0.5 -1.2 1.0 0.1 0.7 -0.0 0.1 -0.2 -0.5 0.2
Prostate Cancer 2.1 2.9 10.6 -1.9 2.7 0.9 2.2 1.3 1.0 -0.1 0.9 -0.4 -0.4 2.5 1.2 1.6 1.5 1.2 2.0 1.0 1.6 1.9 1.9 2.1 2.1 2.2 3.2 2.1 1.8 1.0 0.2 1.8
Age at First Birth 1.7 2.4 4.8 1.3 -1.9 -1.9 -2.1 -1.6 -0.2 -1.7 -1.4 -1.1 -0.7 -2.2 -1.8 -1.8 -2.0 -1.7 -1.4 -1.3 -1.1 -1.4 -1.7 -1.8 -0.2 -1.6 -1.9 -0.7 -2.0 -1.5 -0.5 -2.0
Bipolar Disorder (2011) 0.7 0.6 2.4 0.7 -0.5 -0.9 -0.3 -1.5 -0.6 -0.8 0.2 -0.2 -1.3 -0.2 -0.4 -0.6 -0.4 -0.6 0.0 -0.3 -1.1 0.6 -0.9 0.1 -1.3 -1.0 0.2 0.6 -0.4 0.1 -1.5 -1.4
Body Mass Index (BMI) (2010) 2.8 3.8 9.2 -1.9 2.5 2.4 2.4 1.7 0.5 1.3 1.6 1.5 -0.2 1.7 2.1 3.0 2.4 2.3 1.7 -0.8 -0.3 1.5 2.5 1.8 0.2 2.9 2.1 1.9 2.5 2.4 -0.3 2.6
Coronary Artery Disease (CAD) 1.2 1.4 5.2 -1.5 0.5 1.8 0.8 2.3 0.3 0.7 0.9 2.0 0.1 0.9 1.7 1.6 1.4 1.5 1.1 0.4 0.6 -0.2 1.7 0.1 0.3 1.6 -0.8 0.3 1.5 1.2 0.6 0.8
Crohns Disease (2012) 0.2 0.3 2.5 -0.2 -0.4 -0.3 -0.6 -0.3 0.4 -0.5 0.5 0.2 -0.2 -0.9 -0.1 0.3 -0.4 -0.1 -0.4 -0.6 -1.0 -0.5 -0.3 -0.6 -0.1 -0.5 -0.9 0.0 -0.4 0.1 -1.6 0.6
Mean Putamen Volume 3.4 3.9 13.2 -3.6 2.4 2.3 2.6 1.4 0.6 1.1 1.3 1.5 -0.4 2.3 2.1 2.7 2.3 2.3 2.6 0.6 0.5 1.0 1.5 2.6 0.9 2.6 1.8 2.8 2.4 2.1 -0.3 1.3
Fasting Glucose 0.5 0.6 4.1 2.0 -0.1 -0.4 0.6 -0.9 -0.5 0.8 0.5 -0.1 0.3 0.1 -1.3 -0.2 -0.7 -0.9 0.8 -0.3 0.6 1.4 -1.0 0.6 -0.5 -0.1 1.0 1.1 -0.4 -0.5 0.0 0.8
HbA1C 0.2 0.2 0.8 -0.4 0.3 0.1 0.6 0.3 -0.8 0.9 -0.3 -0.3 0.7 0.7 -0.1 0.3 -0.1 -0.2 0.5 0.5 0.6 0.1 0.5 0.9 0.1 0.6 0.4 -0.1 0.2 -0.1 -0.4 0.3
HDL Cholesterol 0.6 1.1 7.5 -0.1 -0.7 -0.0 -0.8 -0.4 -1.4 -2.7 1.5 0.0 -2.3 -1.2 0.0 -0.1 -0.5 -0.0 0.3 -1.7 -1.8 0.6 0.1 -0.7 0.6 -0.0 -0.2 -0.7 0.3 0.6 -1.6 -0.1
LDL Cholesterol 0.4 0.6 4.8 0.4 -0.2 -0.3 -0.1 2.2 0.9 0.9 -0.3 0.1 1.9 0.3 -0.1 0.0 0.0 -0.2 -0.8 1.6 1.2 -0.6 0.4 -0.2 0.2 -0.3 -0.5 -0.8 -0.3 -0.8 -0.4 -0.4
Lupus 4.7 7.1 17.3 -2.5 2.6 3.9 2.6 1.3 0.3 1.8 3.5 2.7 -0.4 2.3 4.2 3.8 3.6 3.6 3.0 0.1 -0.4 0.9 3.5 2.9 0.1 2.8 1.2 0.1 3.7 3.1 -2.8 3.6
Neuroticism (2016) 9.8 14.1 29.6 5.2 -4.4 -4.2 -4.1 -3.6 -1.3 -1.6 -3.9 -2.3 1.0 -4.5 -4.9 -5.3 -4.7 -4.4 -4.1 0.0 0.1 -1.4 -5.1 -5.4 1.0 -4.5 -4.1 -1.6 -5.2 -4.0 2.6 -3.0
Primary Biliary Cirrhosis 0.9 1.3 6.5 -1.8 0.6 0.6 0.2 1.1 0.9 -0.9 1.2 0.1 -0.9 1.0 1.3 1.4 0.7 0.9 0.3 -0.3 0.0 -0.9 2.0 1.2 1.9 1.0 0.3 -1.0 1.0 0.4 -2.5 1.8
Rheumatoid Arthritis 0.3 0.4 2.0 1.4 -1.0 -0.4 -0.4 0.2 0.6 0.1 0.2 0.6 1.2 -0.6 -0.5 -0.5 -0.5 -0.6 -0.5 0.1 -0.4 -0.2 -0.9 -0.8 -0.3 -0.7 -1.0 -0.5 -0.6 -0.8 -1.1 -0.2
Schizophrenia (2014) 1.1 2.5 14.4 -1.9 1.0 1.6 0.5 0.5 0.0 -2.1 2.4 1.3 -1.9 0.1 1.7 2.3 1.2 1.6 0.8 -0.9 -2.3 0.4 2.0 1.5 -0.3 1.2 0.3 -0.1 1.7 1.8 -3.8 1.1
Triglycerides 11.0 18.0 34.3 4.5 -5.0 -5.1 -5.2 -4.8 -2.9 -1.8 -4.0 -3.6 -0.6 -4.7 -5.5 -5.2 -5.2 -5.1 -5.0 -1.5 -1.8 -2.1 -5.9 -5.1 -3.4 -4.9 -3.4 -3.5 -5.3 -4.5 1.1 -4.8
Type 2 Diabetes (T2D) (2012) 0.9 1.1 8.9 -0.5 0.2 0.2 -0.1 -0.4 -0.5 -0.8 1.2 0.5 -1.9 -0.7 0.9 1.1 0.2 0.5 0.6 -1.9 -1.9 0.3 0.4 0.4 -3.0 0.2 0.1 -0.3 0.7 1.3 -1.4 0.0
Ulcerative Colitis 2.2 3.2 7.2 2.7 -1.5 -1.9 -1.8 -2.1 0.4 -2.3 -2.0 -2.2 -2.5 -2.3 -2.6 -1.9 -2.0 -1.8 -1.2 -1.1 -1.1 0.7 -2.6 -1.3 1.3 -1.2 -0.1 0.7 -2.0 -1.3 -0.3 -2.5
Blood Eosinophil Count 0.0 0.3 1.0 0.1 -0.6 0.5 -0.1 -0.9 -0.5 1.0 0.4 0.2 -0.2 -0.6 -0.1 0.4 0.2 0.3 0.7 -1.0 -0.8 0.7 -0.7 -0.4 -0.5 0.4 -0.7 0.4 0.2 0.2 0.1 0.4
Blood Platelet Count 0.2 1.9 8.0 2.2 -1.2 -1.4 -0.2 -0.1 1.0 2.2 -1.7 -0.6 1.7 -0.5 -1.1 -1.1 -0.8 -1.0 -0.9 2.5 1.8 0.3 -1.5 -0.9 0.1 -0.9 -1.2 -1.1 -1.4 -1.4 2.8 0.4
Blood Red Count 0.7 6.5 16.1 1.0 -1.0 -3.6 -1.5 -2.9 -0.7 0.3 -2.6 -3.3 2.1 0.1 -4.0 -3.3 -3.3 -3.3 -3.6 3.0 2.5 -1.0 -3.9 -1.6 1.5 -2.4 0.4 -0.8 -3.9 -3.7 0.1 -2.1
Blood White Count 0.2 1.7 5.3 0.1 -1.4 -2.3 -1.5 -1.8 -0.1 -0.4 -0.9 -1.8 -0.4 -1.2 -1.4 -1.4 -1.9 -1.8 -1.1 0.7 -0.6 -1.1 -1.5 -0.5 -1.5 -1.7 -0.8 -1.1 -1.6 -1.5 -0.3 -0.9
Heel T-Score 0.1 0.7 3.1 -0.1 -0.1 -0.9 -0.1 -0.6 -0.3 -0.7 -0.7 -0.6 0.6 -0.2 -1.2 -0.3 -1.0 -1.0 -1.1 1.8 0.7 0.5 -1.5 -0.4 0.9 0.6 0.3 0.6 -0.6 -0.5 0.3 -1.6
BMI 0.2 0.9 3.1 1.1 -1.3 -1.0 -0.6 -0.2 -1.2 0.7 0.6 0.2 0.3 -1.3 -0.6 -0.8 -0.9 -1.0 -0.9 -1.0 -1.2 0.5 -1.3 -1.8 -1.0 -0.9 -1.2 -0.5 -0.6 -0.5 0.2 -1.3
Height 0.2 4.7 23.4 -1.8 2.7 0.7 2.5 0.7 1.7 2.8 -2.2 -0.8 2.8 4.0 0.3 0.2 1.1 0.4 0.8 3.7 4.8 0.2 0.5 2.4 2.4 1.5 3.5 2.3 0.3 -0.8 2.8 0.2
Waist Hip Ratio (WHR) 0.5 2.4 9.0 1.6 -1.9 -1.1 -1.6 -0.1 -2.8 1.4 -0.4 -0.4 0.9 -1.7 -1.0 -0.9 -1.2 -1.1 -2.1 0.7 -1.1 -1.1 -1.0 -2.5 -3.0 -1.9 -2.8 -1.5 -1.4 -0.6 0.6 -0.4
Systolic Blood Pressure 1.8 8.9 25.3 -0.9 3.1 3.4 2.8 1.5 1.5 -0.2 2.7 4.1 -2.6 1.2 3.0 3.9 3.3 3.8 3.0 -1.6 -0.9 3.7 3.1 1.0 5.0 4.2 2.7 3.5 3.6 4.0 -2.2 3.2
Smoking Status 0.4 0.8 5.3 -0.3 -1.1 0.0 -1.6 0.1 -0.9 -2.3 0.3 -0.5 -1.4 -1.7 0.2 0.3 -0.2 0.1 0.1 -1.3 -1.7 -0.6 0.9 0.0 -0.6 0.4 -1.3 -0.8 0.0 -0.0 -0.8 -0.1
Allergy or Eczema 0.2 0.4 3.1 0.3 0.0 -0.2 0.4 0.3 -0.9 0.8 -0.3 0.9 0.4 -0.3 -0.2 0.2 -0.2 -0.1 -1.0 1.8 0.1 0.7 -0.7 -1.2 0.1 0.2 -0.6 0.1 -0.2 0.4 1.1 -0.3
Cardiovascular Disease 1.2 3.8 9.6 -0.6 2.3 2.1 2.4 1.4 0.3 1.1 0.9 2.8 -0.8 1.5 2.1 3.0 2.2 2.6 1.8 0.1 0.1 2.7 1.5 0.9 1.4 2.8 1.8 3.1 2.4 3.0 0.2 1.9
Hypothyroidism (self reported) 0.3 0.7 3.0 0.2 0.0 0.9 0.2 -0.4 -1.7 0.6 0.9 1.2 -1.3 -0.4 0.4 0.5 0.8 0.8 1.1 -1.7 -1.2 1.2 -0.3 -0.6 -0.5 0.3 0.1 0.6 0.8 1.1 -0.3 -0.1
Respiratory disease 0.5 1.2 3.8 1.1 -1.3 -1.1 -1.1 0.1 -0.5 -1.4 0.1 -0.7 -1.6 -1.3 -1.2 -1.5 -1.4 -1.2 -0.5 -0.7 -1.4 0.5 -1.1 -1.9 0.0 -1.6 -0.5 0.3 -1.0 -0.3 -1.8 -0.7
Type 2 Diabetes (T2D) (2018) 0.4 0.7 3.1 -0.3 0.3 1.1 0.7 1.2 0.7 1.8 0.6 1.4 0.7 0.1 0.9 1.1 1.2 1.2 1.1 0.9 0.2 0.1 0.9 0.4 0.8 1.2 -0.6 0.3 0.8 0.6 0.2 0.7
Lung FEV1/FVC ratio 0.3 1.6 8.3 -0.0 -0.5 -0.8 0.1 0.5 1.3 1.7 -0.6 -0.2 2.9 1.0 -0.4 -0.0 -0.6 -0.8 -0.6 2.7 1.6 -1.8 0.1 1.2 -0.5 -0.3 -0.9 -2.7 -0.6 -1.9 1.0 0.7
Lung FVC 0.2 0.9 2.8 0.5 -0.6 -0.6 -0.7 -1.7 -0.1 1.6 -0.9 -0.3 1.4 0.6 -0.6 -0.8 -0.4 -0.8 -0.8 1.6 1.4 -1.3 -0.9 -0.4 0.4 -1.1 -0.9 -1.5 -0.9 -1.4 -0.6 0.7
Neuroticism 0.7 1.6 4.2 0.2 -0.7 -2.1 -1.2 0.2 1.1 -0.8 -1.5 -1.5 1.2 0.0 -1.5 -1.3 -1.8 -1.7 -1.5 0.8 1.3 -1.9 -0.5 0.3 0.8 -1.3 -0.9 -1.4 -1.7 -1.9 -0.9 -0.3
Chronotype (morning person) 0.1 0.3 2.5 0.9 -0.2 0.4 0.0 -0.7 -1.6 0.5 -0.3 0.6 0.0 -0.3 -0.2 -0.3 -0.1 -0.1 0.8 0.7 0.4 0.7 -0.3 -0.4 -0.6 -0.4 -0.3 -0.1 -0.1 0.1 0.9 1.2
Hair Pigment 0.1 3.0 10.8 0.2 -1.1 -2.4 -1.9 -2.4 0.5 -1.1 -2.8 -3.3 -1.1 -0.8 -1.7 -1.8 -2.1 -2.3 -2.6 -1.4 -0.8 -1.5 -1.5 0.1 -0.8 -2.0 0.3 -0.8 -2.0 -1.9 -1.4 -1.7
Tanning 0.0 0.5 4.1 -0.8 0.1 -0.1 -0.1 0.1 -0.3 0.2 -1.0 0.0 1.1 1.0 -0.2 -0.7 -0.1 -0.2 0.0 1.7 2.0 -1.0 0.1 0.1 0.0 -0.5 -0.7 -0.7 -0.4 -0.6 0.2 0.4
Hand grip strength (left) 0.2 0.5 1.8 -0.7 0.9 0.9 0.6 -0.6 -0.2 1.0 0.1 0.5 -0.4 0.7 1.0 1.0 1.0 0.9 1.1 0.4 0.3 0.2 0.6 1.3 -0.0 0.8 0.5 -0.4 1.0 0.7 0.1 0.7
Number of treatments/medications taken 0.4 0.8 2.6 -1.6 0.4 0.7 0.7 1.2 -0.1 0.5 1.4 1.6 0.1 0.4 0.9 1.0 0.5 0.6 0.9 -0.7 -0.3 0.5 0.9 -0.2 -0.4 0.1 -0.3 1.1 0.8 1.0 -1.6 1.4
Average weekly spirits intake 3.0 3.7 8.7 2.0 -2.1 -2.5 -2.4 -1.8 -1.4 -1.0 -1.8 -2.0 -0.1 -1.7 -2.3 -2.3 -2.4 -2.3 -2.9 0.1 -0.9 -1.2 -2.1 -2.0 -1.9 -2.1 -1.2 -2.6 -2.4 -2.0 0.8 -2.1
Sensitivity / hurt feelings 4.4 7.5 15.6 3.0 -2.9 -3.5 -3.2 -2.9 -0.4 -1.3 -3.3 -2.6 0.2 -2.5 -3.6 -3.9 -3.6 -3.5 -3.3 -1.0 -0.1 -1.9 -3.4 -3.6 -0.6 -3.8 -1.9 -0.2 -4.0 -3.1 1.8 -1.9
Frequency of depressed mood in last 2 weeks 6.2 8.6 16.0 3.9 -3.4 -3.6 -3.4 -2.9 -2.5 -0.5 -2.7 -2.6 0.7 -3.4 -4.0 -3.7 -3.6 -3.7 -3.4 0.1 -1.0 -1.4 -3.8 -3.2 -1.2 -3.2 -2.6 -2.1 -3.8 -3.2 1.6 -3.2
Hearing difficulty/problems: Yes 0.2 0.3 1.4 -1.2 0.3 -0.1 0.5 0.7 0.7 0.8 0.0 0.1 0.4 0.6 -0.2 0.1 0.0 -0.1 0.3 0.6 0.6 0.4 0.0 0.5 0.4 0.4 0.7 0.8 0.2 -0.1 1.1 0.3
Relative age of first facial hair 0.2 0.4 3.0 0.2 -0.7 0.0 -0.1 0.8 1.3 1.7 0.1 0.5 1.4 -1.0 -0.5 0.1 0.1 -0.1 0.4 0.5 -0.2 0.3 -0.6 -0.9 0.5 0.4 -1.2 -0.0 -0.3 -0.4 0.2 0.2
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 5.0 1.3 -1.5 -0.6 -0.8 -0.1 -1.7 -0.1 0.7 0.5 0.2 -1.4 -0.9 -1.2 -1.0 -1.0 0.0 -1.5 -1.3 0.5 -1.1 -1.9 -2.2 -1.7 -1.2 0.2 -0.8 -0.3 -0.8 -1.1
Ever used hormone-replacement therapy (HRT) 1.2 1.6 5.6 -0.9 1.0 0.8 1.2 0.9 0.2 1.4 2.4 2.2 -0.0 0.9 1.5 1.4 1.3 1.3 1.6 -0.4 -0.1 2.0 1.0 0.3 -0.6 1.0 0.4 1.1 1.6 2.0 -0.4 1.8
Ever had hysterectomy (womb removed) 0.9 1.1 6.0 -0.9 1.4 -0.0 1.3 0.6 -1.0 2.4 1.1 -0.1 2.2 1.3 0.4 0.7 0.6 0.2 0.4 1.8 1.7 0.8 0.2 1.2 -0.4 0.3 0.8 0.5 0.4 0.2 -0.4 0.5
Systolic blood pressure, automated reading 9.8 28.4 53.0 -4.2 6.8 6.2 6.4 3.5 2.2 1.4 5.5 5.2 -2.4 4.7 5.9 7.3 6.7 6.6 6.2 -0.2 -0.1 5.4 6.4 5.7 4.1 7.1 5.7 4.8 6.9 6.6 -4.1 5.3
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.9 0.1 -0.5 -0.5 -0.3 0.3 0.5 -0.2 0.1 -0.4 0.2 -0.0 0.3 -0.2 -0.2 -0.2 -0.6 -0.2 -0.4 -1.0 0.2 0.3 -0.5 -0.5 -0.4 -0.6 -0.1 -0.2 -0.8 -0.2
Angina 0.4 0.5 1.8 -0.8 0.4 0.8 0.3 1.3 -0.8 0.8 0.7 0.5 1.3 0.8 0.7 1.1 0.6 0.6 0.3 0.9 1.2 -0.5 0.8 0.2 -0.3 0.9 -0.5 -0.9 0.7 0.4 0.1 0.4
Medication for hormone replacement therapy 0.6 0.6 3.7 0.1 0.3 0.3 0.5 -0.3 -0.9 0.1 1.9 0.7 -0.6 0.0 0.6 0.6 0.6 0.6 0.9 -1.1 -0.4 1.6 -0.0 -0.2 -0.7 0.3 0.2 0.9 1.1 1.4 -1.0 0.5
Vitamin and mineral supplements 1.8 2.4 5.2 2.0 -1.0 -1.7 -1.1 -1.1 -0.1 0.8 -2.2 -1.9 2.0 -0.1 -1.8 -1.9 -1.4 -1.8 -1.5 1.7 1.8 -0.4 -2.3 -1.3 0.2 -1.0 -0.6 -1.0 -1.8 -2.1 2.2 -2.2
Supplements: Zinc 2.7 2.9 5.9 -2.1 2.1 1.8 1.8 2.2 2.0 -0.3 1.6 1.5 -0.6 1.6 1.9 2.4 1.8 2.2 1.7 -0.2 0.3 1.1 2.1 1.8 0.8 2.0 1.5 1.4 2.0 2.1 -0.4 2.3
Medication: Co-codamol 0.4 0.5 2.6 -0.3 -0.1 -0.2 0.2 0.4 0.6 1.5 -0.0 -0.6 1.6 0.9 -0.0 -0.1 -0.2 -0.5 0.2 1.1 1.1 -0.5 0.2 0.7 1.4 -0.0 0.2 -0.0 -0.0 -1.0 -0.4 1.1
Medication: Metformin 1.9 2.7 6.0 -1.3 1.8 2.3 2.0 1.5 0.5 1.9 2.1 1.6 0.6 1.5 1.9 2.1 2.3 2.2 2.5 0.8 0.6 1.6 1.7 1.6 0.1 1.9 1.2 0.9 2.0 1.9 0.1 1.5
Diabetes (father) 4.2 5.2 9.6 -2.4 2.3 2.6 2.4 2.2 1.5 0.1 3.1 2.7 -0.4 2.0 3.0 2.7 2.9 3.0 3.0 0.6 0.1 0.6 2.9 1.7 2.0 2.1 1.3 2.5 2.8 2.6 -2.3 2.7
Diabetes (mother) 0.5 0.7 3.3 -0.5 0.6 0.2 0.7 0.6 0.7 0.6 1.1 0.6 -1.6 0.3 0.1 0.8 0.2 0.3 0.7 -0.7 -0.9 1.8 -0.0 0.9 -0.1 1.0 1.3 1.3 0.8 1.1 -0.6 0.5
Severe depression (siblings) 1.1 1.2 3.9 -0.9 1.5 1.4 1.2 1.1 0.6 0.5 1.0 1.0 0.1 1.1 0.8 0.7 0.9 0.9 1.6 0.4 0.4 1.0 0.8 1.1 2.0 1.2 1.6 2.0 0.8 0.8 -1.4 0.5
Pack years adult smoking proportion 0.4 0.7 2.2 -0.9 1.0 0.7 0.7 0.7 -0.5 -0.1 1.5 -0.6 -0.6 0.3 0.8 1.4 0.6 0.7 1.1 -0.3 -0.6 0.9 0.9 0.8 -0.9 1.3 0.9 -0.1 1.0 0.8 -0.4 0.4
Impedance of leg (right) 5.0 24.0 49.6 7.0 -6.4 -5.2 -6.5 -3.8 -0.9 -4.3 -4.5 -2.1 -1.3 -6.8 -6.0 -6.6 -6.1 -5.3 -5.1 -2.3 -2.9 -2.6 -5.6 -6.7 -2.6 -6.5 -5.2 -2.2 -6.6 -4.1 2.1 -4.3
Leg fat-free mass (left) 2.1 11.0 21.2 -4.4 4.4 3.5 4.4 2.3 1.3 3.6 2.8 1.4 1.2 4.4 4.1 4.6 4.3 3.7 3.3 1.9 1.8 2.0 3.7 4.3 1.3 4.6 3.6 1.7 4.5 2.9 -0.5 3.0
Trunk fat percentage 0.3 1.3 3.3 0.0 0.8 1.5 1.4 1.0 1.1 1.5 1.8 1.4 0.4 0.2 1.3 1.8 1.6 1.6 1.0 -0.2 -0.9 1.5 0.9 1.0 -1.1 1.1 0.1 0.6 1.3 1.8 -0.7 0.7
Hand grip strength (right) 0.1 0.3 1.1 -0.3 0.7 0.6 0.3 -0.5 0.2 0.5 0.1 -0.1 -0.3 0.7 0.4 0.4 0.5 0.5 0.9 0.5 0.9 0.4 0.2 0.7 1.1 0.5 0.7 -0.7 0.6 0.4 -0.1 0.6
Townsend deprivation index at recruitment 0.7 1.0 4.3 -0.2 0.1 0.2 -0.1 -1.0 -2.1 -1.5 0.5 -1.0 -1.9 -0.5 -0.6 0.0 -0.5 -0.4 0.4 -1.9 -0.7 1.4 -0.7 -0.3 0.8 0.3 1.3 1.8 -0.0 0.1 -1.7 0.2
Current tobacco smoking 1.8 3.0 9.5 -2.5 1.9 1.6 1.5 1.6 0.4 -0.0 2.3 -0.0 -1.0 1.6 1.9 2.3 2.0 1.8 2.2 0.4 -0.4 1.1 2.4 3.1 -1.2 2.2 2.0 0.1 2.2 1.9 -1.7 0.8
Average weekly fortified wine intake 1.8 2.1 6.8 1.3 -1.7 -1.1 -1.6 -1.6 -0.2 -0.3 -2.6 -0.9 0.3 -0.6 -1.7 -1.9 -1.7 -1.6 -2.0 0.7 0.8 -2.2 -1.9 -1.4 0.2 -1.5 -1.1 -1.2 -2.0 -2.0 1.1 -0.8
Maternal smoking around birth 1.8 2.7 6.1 1.7 -2.4 -2.0 -2.4 -1.8 -1.1 -1.5 -0.5 -0.8 -0.5 -2.1 -1.5 -1.8 -1.8 -1.6 -1.6 -1.0 -1.3 -0.6 -1.8 -2.0 -1.6 -2.5 -1.9 -1.7 -1.6 -1.1 -1.4 -1.2
Fed-up feelings 5.5 10.0 19.4 3.7 -3.6 -4.2 -4.0 -3.0 -1.5 -2.4 -3.4 -3.0 0.1 -3.2 -3.8 -4.4 -4.2 -4.0 -3.8 -0.8 -0.5 -2.4 -3.5 -3.7 -0.6 -3.9 -2.7 -2.4 -4.1 -3.5 1.3 -2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 3.7 1.6 -1.7 -1.7 -1.8 -1.3 -1.9 -0.3 -1.4 -1.2 0.4 -1.9 -1.8 -1.9 -1.8 -1.8 -1.9 0.8 -0.8 -1.0 -1.7 -1.5 -1.0 -1.8 -1.3 -0.7 -1.9 -1.4 0.6 -1.4
Relative age voice broke 1.1 1.6 4.3 0.2 -1.9 -1.7 -1.6 0.1 0.1 0.2 -1.4 -1.1 0.8 -1.2 -1.8 -1.3 -1.5 -1.7 -1.5 -0.1 -0.2 -0.9 -1.3 -1.2 -1.3 -1.1 -1.7 -2.1 -1.6 -1.7 0.1 -1.0
Taking other prescription medications 0.4 0.6 1.6 0.4 -1.2 -1.3 -0.7 0.1 -0.6 0.7 -0.4 -0.4 0.3 -0.8 -1.1 -0.8 -1.0 -1.1 -0.6 -1.0 -0.1 0.1 -1.2 -1.3 -1.0 -1.0 -0.9 -0.3 -0.8 -0.7 -0.0 -0.4
Age when periods started (menarche) 3.2 7.7 14.7 2.7 -3.1 -3.2 -3.1 -2.8 -1.6 -2.6 -2.5 -3.0 -0.4 -2.8 -3.2 -3.5 -3.6 -3.3 -2.9 -1.2 -0.7 -2.2 -3.1 -2.3 -3.1 -3.8 -2.1 -2.2 -3.5 -3.0 0.8 -3.8
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 5.3 -0.1 -0.9 -1.7 -1.2 -1.1 -1.1 1.4 -1.7 -1.4 1.7 -0.5 -1.7 -1.2 -1.5 -1.7 -2.3 1.0 0.9 -1.4 -1.5 -0.9 -1.3 -1.5 -1.2 -2.0 -1.9 -2.0 0.1 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 8.7 19.7 47.2 -5.6 5.5 4.4 5.5 4.9 4.3 2.5 4.2 2.4 0.1 5.3 4.8 6.3 5.2 4.7 5.1 1.5 1.5 2.9 4.9 6.9 1.3 6.3 4.6 2.6 5.7 4.2 -3.2 3.1
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 4.6 -2.1 1.6 1.0 1.4 1.3 1.4 0.3 0.1 -0.2 0.4 1.8 1.1 1.5 1.2 1.0 1.2 1.1 0.9 0.6 1.5 2.1 1.1 1.8 1.8 0.3 1.4 0.5 -0.1 0.6
Qualifications: CSEs or equivalent 0.3 0.4 1.5 0.8 -0.6 -0.5 -0.5 -1.2 -0.1 -0.8 -1.0 -0.5 0.5 -0.4 -0.6 -0.6 -0.6 -0.6 -0.6 0.1 0.2 -0.2 -1.0 -0.1 -1.2 -0.7 -0.5 -0.2 -0.6 -0.2 1.1 -0.9
Serious illness, injury or assault to yourself 2.4 2.9 7.4 1.6 -2.6 -1.6 -2.0 -1.8 -1.6 0.0 -0.9 -0.2 -0.4 -2.3 -1.9 -1.7 -1.7 -1.5 -1.7 -1.5 -1.6 -0.6 -1.9 -2.3 -2.7 -2.3 -2.7 -1.7 -1.9 -1.0 0.2 -0.7
High blood pressure 9.0 25.0 48.5 -4.8 6.3 5.7 6.2 4.0 2.3 2.3 4.6 4.4 -1.6 5.2 5.8 7.0 6.0 6.1 5.4 0.2 1.0 4.9 5.6 5.4 3.1 6.9 5.2 4.9 6.6 6.0 -2.5 5.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 3.3 -0.5 0.4 0.6 1.0 1.4 -0.1 1.8 0.5 1.3 0.2 -0.1 0.4 1.3 0.6 0.6 -0.0 1.1 -0.3 1.0 0.1 0.0 0.8 1.4 -0.2 0.3 0.8 0.8 0.3 0.4
Multivitamins +/- minerals 1.6 2.0 5.8 -0.9 0.9 1.4 0.9 0.2 -0.3 -0.3 2.4 1.6 -2.1 -0.2 1.1 1.7 1.2 1.5 1.6 -1.5 -1.9 1.4 1.2 0.6 1.1 1.1 0.9 1.7 1.5 1.9 -2.0 1.8
Stomach or abdominal pain in last month 6.6 8.2 16.7 2.4 -4.0 -3.2 -4.1 -2.1 -0.4 -4.1 -0.8 -2.5 -1.1 -3.8 -2.6 -3.0 -3.7 -3.2 -2.9 -1.9 -2.0 -2.7 -3.0 -3.1 -1.8 -3.3 -3.7 -3.3 -3.0 -2.9 -0.0 -2.8
Supplements: Glucosamine 1.2 1.5 5.3 -0.9 0.6 1.9 1.1 1.8 0.4 0.5 1.4 2.3 -0.5 0.1 1.7 1.4 1.6 1.7 2.2 -0.3 -0.6 0.8 1.5 0.5 0.0 1.1 0.0 1.2 1.5 1.6 -0.1 0.9
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.2 0.1 0.1 0.6 0.4 -0.8 -0.2 0.1 0.8 0.3 -0.4 -0.4 0.8 0.0 0.6 0.7 0.8 -0.7 -0.8 0.8 -0.0 -0.6 -1.0 -0.4 -0.4 0.8 0.5 1.1 0.2 0.9
Medication: Atenolol 3.0 3.8 7.8 -1.3 2.4 2.6 2.5 1.4 0.2 1.1 2.5 2.3 -0.6 1.8 2.7 2.5 2.6 2.6 2.3 -0.1 -0.0 1.7 2.3 1.4 -0.7 2.1 1.5 1.4 2.8 2.8 -0.2 2.1
Medication: Levothyroxine sodium 3.0 5.1 15.3 2.7 -3.0 -1.9 -3.0 -2.0 -1.9 -1.4 -2.4 -0.9 -1.2 -2.9 -2.4 -2.8 -2.5 -2.3 -2.2 -2.3 -1.6 -0.7 -2.8 -3.9 -1.9 -2.6 -2.0 -0.9 -2.4 -1.5 1.6 -2.2
Sitting height 1.4 10.3 23.8 -3.5 4.6 2.5 4.1 4.0 3.7 2.8 1.0 1.2 2.0 4.9 3.1 3.2 3.4 3.0 2.7 3.3 3.7 1.1 3.6 4.2 3.3 3.7 3.9 2.2 3.2 1.9 0.4 3.2
Chronic bronchitis/emphysema (father) 0.7 0.9 4.9 1.0 -0.7 -0.5 -0.7 -0.8 -0.2 -1.1 0.1 -1.4 -1.9 -1.0 -1.1 -0.5 -0.9 -0.8 0.4 -2.2 -1.0 1.5 -0.9 -0.6 -0.9 -0.3 0.5 0.2 -0.4 0.2 -0.2 -0.6
High blood pressure (mother) 2.2 3.0 6.2 -2.4 2.4 1.9 2.1 0.3 0.4 1.5 1.7 1.2 0.1 2.3 1.7 2.0 1.8 1.8 2.0 -0.3 0.8 1.2 1.7 1.4 2.1 2.0 2.5 2.0 1.9 1.3 -1.5 2.4
Body mass index (BMI) 3.8 16.3 36.6 -4.8 4.8 4.7 5.1 3.6 1.4 3.1 4.9 2.5 0.7 4.4 5.1 6.1 5.3 4.9 4.4 0.9 0.7 3.0 4.7 4.9 0.3 5.2 3.4 1.7 5.7 4.5 -1.9 3.7
Impedance of leg (left) 5.7 27.6 60.4 7.8 -6.8 -5.5 -6.8 -4.0 -1.2 -4.1 -5.0 -2.0 -0.8 -7.0 -6.3 -7.2 -6.5 -5.7 -5.7 -2.0 -2.7 -3.0 -6.1 -7.0 -3.0 -7.2 -5.7 -2.5 -7.2 -4.5 2.4 -4.9
Leg predicted mass (left) 2.0 10.8 20.7 -4.3 4.3 3.5 4.4 2.3 1.4 3.6 2.8 1.4 1.2 4.3 4.0 4.5 4.3 3.7 3.3 1.8 1.8 2.0 3.6 4.3 1.3 4.5 3.5 1.7 4.4 2.9 -0.5 2.9
Trunk fat mass 0.8 3.5 8.5 -1.1 2.0 2.3 2.5 1.8 1.3 2.6 2.2 1.6 0.9 1.5 2.3 2.9 2.6 2.4 1.8 0.5 -0.0 1.9 1.9 1.9 -0.5 2.3 1.2 0.9 2.4 2.3 -0.3 1.5
Waist circumference 0.6 2.1 5.6 -1.1 1.5 1.7 2.0 1.6 0.2 2.4 1.6 1.1 1.3 1.5 1.9 2.3 2.0 1.8 1.2 0.9 0.4 1.3 1.4 0.9 -0.5 1.6 0.4 0.6 2.0 1.8 0.5 1.6
Number of incorrect matches in round 0.3 0.5 1.7 0.8 -0.5 -1.1 -0.7 -1.3 -0.4 0.5 -0.6 -0.0 0.4 -0.4 -0.9 -0.8 -0.6 -0.5 -1.2 -0.1 -0.0 0.5 -0.8 -1.3 0.6 -0.9 0.1 0.2 -0.8 -0.1 0.4 0.4
Past tobacco smoking 1.7 3.1 7.5 1.7 -0.5 -2.3 -0.6 -0.5 1.8 0.9 -2.7 -1.3 2.3 0.9 -2.2 -2.4 -1.7 -2.1 -2.1 2.7 2.2 -1.4 -1.9 -0.8 1.3 -1.6 0.6 -0.7 -2.1 -2.6 1.5 -1.7
Alcohol usually taken with meals 1.7 2.8 10.3 -3.2 1.7 2.0 1.9 1.4 0.6 0.8 1.4 0.9 1.2 2.2 1.8 2.3 1.9 1.7 1.8 1.5 1.4 0.3 2.0 2.4 0.8 2.1 1.2 0.7 1.9 0.8 0.3 2.4
Nervous feelings 5.1 9.5 19.7 4.1 -4.1 -3.1 -3.9 -2.3 -0.7 -0.7 -3.7 -1.3 1.0 -4.0 -3.6 -4.4 -3.4 -3.2 -3.0 -0.6 -0.7 -2.2 -3.5 -4.3 -0.1 -4.1 -3.9 -1.1 -4.4 -3.3 2.7 -2.5
Frequency of tenseness / restlessness in last 2 weeks 3.6 5.6 10.9 2.0 -2.6 -3.0 -3.0 -1.6 -1.4 -1.7 -2.4 -2.9 -0.0 -2.5 -3.3 -2.8 -3.2 -3.1 -3.2 -0.2 -0.8 -1.4 -2.7 -1.8 -1.8 -2.9 -1.4 -1.6 -3.2 -2.5 0.1 -3.3
Hearing difficulty/problems with background noise 0.8 1.3 2.8 -0.2 -1.4 -1.5 -1.4 -1.1 -1.2 -1.7 -0.4 -1.1 -0.3 -1.2 -1.4 -1.2 -1.6 -1.4 -1.1 -1.3 -0.4 -0.8 -1.4 -1.3 -1.1 -1.3 -1.0 -0.9 -1.3 -1.0 0.4 -1.0
Hair/balding pattern: Pattern 2 0.5 0.7 6.4 -0.1 0.0 0.9 -0.3 0.0 -0.3 -0.5 1.0 0.7 -0.8 -0.4 0.9 0.4 0.6 0.7 0.2 -0.3 -1.6 -0.6 0.9 0.9 -2.5 -0.3 -0.8 -0.7 0.6 0.7 -0.9 0.7
Had menopause 4.6 5.8 13.3 -1.3 3.3 3.0 3.1 1.5 0.8 0.7 2.6 2.2 -0.6 2.1 2.6 2.7 3.0 3.0 3.1 1.4 0.4 3.2 2.0 1.6 1.5 3.1 2.7 3.7 2.9 3.4 0.4 1.7
Had other major operations 0.8 1.0 3.1 -1.6 1.0 1.1 1.0 0.9 0.0 0.3 0.9 0.1 -0.8 0.7 1.3 1.8 1.4 1.3 0.4 0.2 -0.2 0.4 1.0 1.2 -1.0 1.5 0.5 -0.7 1.6 1.3 0.0 0.3
Forced vital capacity (FVC) 1.0 3.8 9.5 1.9 -1.8 -2.2 -2.2 -2.7 -0.4 0.1 -3.1 -1.6 0.9 -1.1 -2.1 -2.7 -2.3 -2.3 -2.5 1.0 1.1 -2.3 -2.1 -1.9 -0.3 -2.5 -1.7 -1.6 -2.7 -2.4 1.8 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 7.8 17.8 45.7 -5.2 5.0 4.1 5.1 4.5 3.8 2.5 4.6 2.4 0.0 4.8 4.5 6.2 5.0 4.4 4.9 1.4 1.1 3.0 4.6 6.8 1.0 5.7 4.2 1.9 5.5 4.1 -3.7 3.3
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 2.2 0.6 0.1 -0.1 0.3 -0.4 0.1 0.7 -0.4 0.7 1.5 0.4 0.2 -0.2 0.0 -0.1 -0.6 0.5 0.4 -0.5 -0.3 -0.1 0.2 -0.1 -0.1 0.3 -0.2 -0.2 0.0 -0.0
Qualifications: None of the above 1.4 3.0 7.1 -1.7 1.1 2.4 1.2 1.4 -0.1 -0.8 2.6 1.3 -1.8 0.3 2.1 2.5 2.0 2.3 2.1 -1.8 -1.4 1.4 1.9 0.9 -1.0 2.4 0.6 1.5 2.5 2.7 -0.2 1.5
Financial difficulties in last 2 years 0.5 0.6 3.7 -1.1 0.9 0.5 0.9 1.1 0.5 0.1 -0.1 -0.5 0.2 1.0 0.2 0.8 0.4 0.2 0.8 0.5 0.7 0.4 0.8 1.9 0.6 1.3 1.3 0.8 0.7 0.1 0.7 0.4
Mouth/teeth dental problems 0.8 1.3 8.6 0.8 -0.8 -0.9 -1.5 -1.8 -0.1 -2.9 -1.6 -1.3 -1.6 -0.9 -0.9 -1.8 -1.1 -0.8 -1.0 0.1 0.1 -0.7 -0.8 -0.8 0.3 -1.3 -0.1 -0.5 -1.2 -0.7 0.5 -0.9
Heart attack 0.5 0.7 3.0 0.5 -0.7 -0.4 -0.7 -0.3 -0.8 -0.2 -0.6 -1.0 1.6 -0.1 -0.3 -0.5 -0.7 -0.7 -0.9 0.5 1.1 -1.7 -0.4 -0.4 -0.7 -0.6 -1.1 -1.2 -0.8 -1.2 0.5 -0.7
Allergy 0.3 0.7 2.9 1.5 -0.6 -0.4 -0.9 -1.7 0.1 -1.0 -1.4 -0.6 0.1 -0.8 -0.6 -1.2 -0.6 -0.6 -0.5 -0.9 0.3 -0.7 -0.5 -0.2 -0.3 -1.1 -0.4 -0.1 -1.1 -0.8 1.2 -0.5
Pain all over the body in last month 1.2 1.3 2.3 -0.7 1.4 1.2 1.4 1.3 0.5 1.2 0.9 0.4 1.0 1.5 0.8 1.0 1.1 1.0 1.0 1.5 1.4 1.3 0.7 1.5 1.0 1.3 1.2 0.7 1.1 0.7 1.1 1.4
Diabetes (self-reported) 1.5 2.4 5.1 -0.5 1.1 2.2 1.5 1.5 0.3 2.1 2.1 2.2 0.1 0.6 1.8 2.2 2.2 2.3 1.8 0.1 -0.5 1.2 1.7 0.9 -0.2 1.8 0.0 0.8 2.0 2.0 -0.4 2.1
Hayfever/allergic rhinitis (self-reported) 2.4 3.2 8.3 1.0 -1.7 -2.4 -1.9 -1.1 -1.3 0.6 -2.1 -1.7 0.8 -1.2 -2.3 -2.5 -2.3 -2.4 -2.9 0.8 0.1 -1.2 -2.1 -2.2 0.1 -2.3 -0.8 -1.4 -2.4 -2.2 -0.4 -2.0
Medication: Ramipril 2.1 2.7 8.5 -2.9 2.6 1.6 2.4 1.0 0.3 1.3 0.8 0.3 0.1 2.7 1.6 2.0 1.6 1.5 1.1 0.3 1.1 1.3 1.6 2.2 -0.0 1.9 2.8 1.6 2.0 1.7 -0.2 1.2
Medication: Simvastatin 0.8 1.2 2.8 -0.9 1.4 1.0 1.6 0.1 -0.6 1.7 0.2 1.3 0.9 1.3 1.4 1.4 1.1 1.1 0.7 0.4 0.3 0.5 1.3 0.7 0.4 0.9 0.7 1.6 1.3 1.6 -1.1 1.3
Fluid intelligence score 3.2 6.6 12.4 2.8 -3.5 -2.9 -3.1 -2.7 -2.3 0.6 -1.9 -1.8 0.5 -3.0 -2.9 -2.7 -2.9 -3.0 -3.1 -1.4 -1.4 -1.4 -3.4 -3.5 -2.0 -3.0 -3.3 -2.0 -3.2 -2.9 0.4 -2.5
Illnesses of siblings 2.0 2.8 6.6 1.0 -1.7 -2.0 -2.0 -1.4 -2.4 -0.7 -0.9 -2.0 0.8 -1.0 -1.5 -1.8 -1.8 -1.8 -1.8 0.4 0.3 -2.3 -1.7 -1.8 -1.0 -1.9 -1.8 -2.6 -1.8 -2.1 0.4 -2.0
Neuroticism score 10.3 21.4 41.5 5.1 -5.6 -5.7 -5.9 -3.7 -1.0 -2.7 -5.7 -3.6 0.7 -5.0 -6.0 -6.4 -6.2 -5.9 -5.4 -0.9 -0.4 -3.6 -5.4 -5.5 0.3 -5.7 -4.5 -2.3 -6.4 -5.5 2.3 -4.1
Weight 2.0 9.8 20.5 -3.6 4.0 3.5 4.2 2.8 1.8 3.2 2.8 1.7 1.2 3.7 3.8 4.5 4.1 3.7 3.2 1.4 1.4 2.3 3.5 3.8 0.9 4.3 3.0 1.6 4.2 3.2 -0.1 2.8
Impedance of arm (right) 5.6 26.0 52.1 7.1 -6.9 -5.1 -6.4 -4.5 -1.1 -3.7 -4.9 -2.4 -0.6 -7.2 -6.2 -7.1 -6.2 -5.5 -5.4 -2.0 -2.8 -3.3 -6.1 -6.2 -2.0 -6.9 -6.0 -2.1 -7.2 -4.8 1.4 -4.6
Arm fat percentage (right) 1.6 6.1 15.6 -2.4 2.5 3.3 3.0 2.3 1.5 1.8 3.5 1.9 0.4 1.7 3.3 4.0 3.4 3.4 2.7 -0.1 -0.5 1.9 2.8 2.7 -0.4 3.0 1.1 0.9 3.4 3.2 -1.3 2.4
Trunk fat-free mass 1.5 8.5 16.9 -4.0 4.1 2.9 3.7 2.5 1.6 3.0 1.8 1.3 1.0 4.1 3.6 3.8 3.7 3.2 2.8 2.0 2.4 1.5 3.3 3.3 1.7 4.0 3.3 1.4 3.8 2.4 0.6 2.7
Hip circumference 2.1 8.9 17.5 -3.3 3.7 3.3 4.0 2.8 2.0 2.8 2.6 1.9 1.2 3.5 3.8 4.2 4.0 3.6 3.1 1.6 1.2 2.0 3.5 3.8 0.7 3.8 2.7 1.6 3.9 3.1 -0.6 2.8
Time employed in main current job 1.9 2.2 6.3 1.5 -2.2 -1.4 -2.3 -0.2 0.8 -2.0 -0.4 0.4 -0.7 -2.3 -1.1 -1.3 -1.5 -1.2 -1.9 -1.0 -1.9 -1.5 -1.2 -1.8 -0.4 -1.6 -2.5 -0.9 -1.6 -1.0 -0.5 -1.9
Alcohol intake versus 10 years previously 0.5 0.8 4.6 0.6 0.0 -0.5 0.1 -1.4 -2.1 0.7 -1.2 -1.0 1.3 0.0 -1.0 -0.9 -0.6 -0.8 -1.0 1.2 1.0 0.2 -1.1 -0.6 -0.3 -0.6 0.3 0.5 -0.9 -0.5 0.8 -0.6
Father’s age at death 0.9 1.2 6.5 0.6 -0.9 -1.0 -1.2 -0.4 0.3 -2.6 -0.9 -0.1 -0.1 -0.7 -0.7 -1.6 -1.2 -0.9 -1.3 0.9 0.5 -1.1 -0.9 -1.6 1.6 -0.9 -0.9 -0.6 -1.3 -1.0 1.2 -0.8
Worrier / anxious feelings 9.1 17.1 33.8 5.5 -5.1 -4.7 -5.1 -3.6 0.0 -2.7 -4.8 -2.5 0.5 -5.0 -5.2 -5.8 -5.4 -4.9 -4.4 -1.1 -0.7 -2.3 -5.1 -5.7 1.1 -4.9 -4.0 -1.1 -5.8 -4.4 2.7 -3.8
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.7 6.1 1.9 -1.9 -1.7 -2.0 -2.2 -1.7 -0.6 -1.1 -0.7 -1.0 -2.4 -2.0 -2.2 -1.8 -1.7 -1.7 -1.3 -1.4 -0.3 -1.9 -2.0 -1.3 -2.5 -1.7 -0.7 -2.2 -0.9 0.1 -0.9
Falls in the last year 0.6 0.8 2.6 0.1 0.4 0.9 0.1 0.3 -0.6 -0.2 1.0 0.7 -1.4 -0.6 0.6 1.0 0.9 1.0 0.9 -1.1 -1.6 1.2 0.9 0.3 0.0 1.1 0.5 0.5 0.8 1.2 -1.5 1.0
Hair/balding pattern: Pattern 3 0.6 0.9 2.2 -1.1 0.7 0.8 1.2 1.3 0.5 0.4 1.3 1.5 0.8 0.8 1.4 1.0 1.2 1.1 0.9 0.1 -0.3 0.0 1.3 0.5 0.8 0.7 0.3 1.1 1.1 1.2 0.1 0.1
Number of live births 0.4 0.5 3.0 0.1 -0.2 -0.8 -0.4 -1.2 -1.5 -0.6 0.2 -1.1 -0.0 -0.2 -0.7 -0.3 -0.8 -0.8 -0.7 -0.9 -0.2 0.1 -0.9 -0.7 0.3 -0.8 0.1 0.7 -0.6 -0.3 -1.7 -0.7
Forced expiratory volume in 1-second (FEV1) 2.5 8.6 21.7 3.0 -2.9 -3.2 -3.1 -3.6 -0.6 0.5 -4.7 -2.5 1.7 -2.1 -3.4 -3.8 -3.4 -3.4 -3.8 1.5 1.1 -2.9 -3.4 -2.8 -0.7 -3.5 -2.6 -2.8 -3.9 -3.6 3.0 -1.9
Pulse rate 2.5 4.2 8.3 2.4 -2.3 -2.2 -2.2 -1.7 -1.4 -0.9 -2.4 -2.3 -0.1 -2.2 -2.3 -1.9 -2.2 -2.2 -2.4 -1.1 -1.1 -1.8 -2.1 -2.4 -2.6 -2.6 -1.8 -2.9 -2.3 -2.0 1.1 -2.0
Happiness 0.6 0.8 3.5 0.0 0.4 0.4 0.0 1.4 0.4 0.5 -0.1 0.4 1.6 1.0 0.5 0.4 0.2 0.2 0.2 1.3 1.4 -1.0 1.0 0.1 1.9 0.9 0.1 -0.8 0.2 -1.1 1.2 1.3
Noisy workplace 0.2 0.2 1.3 -0.8 0.1 0.0 0.2 -0.1 -1.1 0.7 -0.4 -0.1 -0.4 0.6 -0.3 -0.3 -0.2 -0.3 0.2 -0.7 0.1 0.2 0.2 -0.0 -0.4 -0.3 0.9 1.0 -0.0 -0.0 -0.1 0.3
Qualifications: A levels/AS levels or equivalent 2.9 6.5 17.1 2.6 -3.8 -2.0 -3.5 -1.6 -0.9 -1.4 -1.7 -0.9 -1.1 -4.1 -2.4 -3.0 -2.5 -2.4 -2.3 -1.7 -2.8 -1.6 -2.6 -3.4 -2.0 -3.2 -3.8 -3.0 -2.6 -1.9 0.2 -3.5
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 4.1 2.0 -1.6 -1.0 -1.7 -0.5 -0.7 -0.4 -1.6 -1.0 -0.6 -1.8 -0.9 -1.8 -1.3 -1.1 -1.6 -1.7 -0.9 -1.1 -0.9 -1.9 -0.6 -1.7 -1.2 -0.7 -1.5 -0.9 1.7 -1.0
Mouth/teeth dental problems: Dentures 0.9 1.6 4.8 -2.2 1.0 0.5 1.5 1.7 1.1 1.3 1.2 -0.5 0.7 1.6 0.7 1.9 0.9 0.5 1.5 0.1 0.9 1.4 0.8 1.9 0.7 2.0 1.5 0.7 1.4 0.3 -1.7 0.6
Asthma 0.3 0.5 5.9 -0.7 0.2 0.1 0.3 0.5 0.0 -0.3 1.5 0.1 -1.1 0.1 0.2 0.1 0.2 0.2 0.8 0.0 -1.1 0.7 0.1 0.0 -0.4 -0.5 0.5 0.9 0.4 0.9 -2.4 0.4
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 5.8 1.1 -1.9 -0.5 -1.5 -0.8 -1.6 -1.3 0.5 1.0 -1.1 -2.3 -0.2 -0.3 -0.8 -0.4 -0.6 -1.7 -2.1 -0.9 -0.2 -2.0 -1.4 -0.9 -2.4 -0.6 -0.7 -0.1 -0.0 -0.5
Medication: Cholesterol lowering 0.3 0.4 3.9 -0.1 0.4 0.2 0.6 -0.1 -1.5 0.7 -0.4 -0.3 2.0 0.5 0.2 0.5 0.0 0.1 -0.1 0.1 1.2 -0.2 0.1 -0.7 -0.4 -0.0 -0.3 -0.1 0.1 0.0 0.7 0.9
Depression (self-reported) 2.4 2.8 6.9 1.8 -1.4 -2.4 -1.5 -1.4 -0.5 -0.7 -1.8 -2.5 0.9 -0.6 -2.5 -2.3 -2.3 -2.6 -2.1 0.5 0.7 -0.3 -2.3 -0.8 -0.2 -1.7 -0.2 -0.7 -2.1 -2.3 1.9 -2.1
Medication: Lansoprazole 1.0 1.2 2.5 0.9 -1.3 -0.9 -1.5 -0.8 0.3 -1.3 -1.3 -0.8 0.3 -0.9 -1.0 -1.2 -1.4 -1.4 -1.1 0.0 -0.2 -1.5 -0.9 -0.0 -0.9 -1.3 -1.4 -1.4 -1.3 -1.6 -0.0 -1.3
Prospective memory result 2.1 2.5 6.1 -1.0 2.5 1.5 2.3 1.4 -1.1 0.9 0.3 0.8 0.9 2.3 1.3 1.4 1.3 1.2 1.5 1.9 2.4 1.5 1.6 1.4 1.8 2.0 2.4 1.9 1.5 1.0 1.4 1.4
Lung cancer (father) 1.2 1.4 8.0 0.9 -0.7 0.1 -0.2 -0.0 -0.2 -0.5 1.1 2.1 -2.0 -1.4 0.4 0.1 0.1 0.4 0.4 -2.7 -2.8 0.6 0.4 -0.7 -1.3 -0.4 -0.8 0.5 0.4 1.4 -2.2 0.3
Illnesses of mother 0.4 0.5 1.5 0.8 -0.3 -0.6 -0.1 0.1 -0.5 -0.1 -0.4 -0.7 0.6 0.2 -0.7 -0.8 -0.5 -0.8 -0.7 1.2 0.6 -0.1 -0.7 0.2 -1.1 -1.2 0.2 -0.5 -0.7 -0.6 1.0 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 2.3 7.3 16.6 2.7 -2.5 -3.1 -2.7 -3.2 -0.5 1.0 -4.1 -2.2 2.4 -1.1 -3.0 -3.6 -3.0 -3.2 -3.5 2.0 1.9 -3.0 -3.0 -2.6 0.4 -3.2 -2.2 -2.4 -3.6 -3.7 2.2 -1.5
Pulse wave Arterial Stiffness index 1.9 2.2 8.5 -2.9 1.3 1.3 1.3 1.9 0.2 1.7 0.2 0.5 2.2 1.8 1.8 1.1 1.3 1.1 0.5 1.8 2.2 -2.2 2.0 1.5 -0.3 1.1 -0.3 -0.7 1.2 -0.0 1.5 1.6
Impedance of arm (left) 6.0 27.6 54.8 7.2 -7.0 -5.3 -6.6 -4.7 -1.0 -3.8 -5.0 -2.5 -0.8 -7.3 -6.5 -7.4 -6.4 -5.7 -5.6 -2.2 -3.1 -3.2 -6.3 -6.4 -1.8 -7.2 -5.9 -2.4 -7.4 -4.9 0.7 -4.9
Arm fat mass (right) 2.4 9.9 23.1 -3.4 3.7 3.9 4.0 2.9 1.5 2.7 3.9 2.3 0.9 3.0 4.2 4.8 4.3 4.1 3.3 0.8 0.3 2.2 3.7 3.6 -0.2 4.0 2.1 1.2 4.3 3.7 -1.1 2.9
Trunk predicted mass 1.4 8.2 16.5 -4.0 4.0 2.8 3.6 2.4 1.4 2.9 1.8 1.3 1.1 4.1 3.5 3.7 3.6 3.2 2.8 2.0 2.3 1.4 3.3 3.2 1.6 3.9 3.2 1.3 3.7 2.4 0.6 2.7
Standing height 0.5 4.6 18.4 2.5 -1.5 -2.4 -1.8 -1.6 1.0 0.6 -4.3 -1.5 1.5 -1.3 -2.5 -3.0 -2.1 -2.2 -2.5 1.5 1.6 -1.5 -2.4 -2.3 0.7 -1.9 -0.9 -0.2 -2.9 -2.6 3.8 -1.8
Length of working week for main job 0.6 0.6 3.8 -1.3 -0.3 0.2 -0.3 0.6 -0.3 0.5 0.0 0.7 1.5 -0.5 0.3 0.6 0.0 0.2 -0.3 0.8 -0.1 -1.3 0.3 -0.1 -2.0 -0.1 -1.6 -1.9 -0.0 0.1 -0.3 -0.1
Exposure to tobacco smoke at home 0.6 0.6 2.3 0.1 -0.4 0.5 -0.2 0.3 -0.4 -0.6 1.3 0.7 -1.5 -0.6 0.3 0.9 0.2 0.3 0.8 -1.4 -1.2 0.5 0.3 -0.1 1.2 1.1 -0.4 1.0 0.5 0.2 -1.5 0.0
Breastfed as a baby 0.4 0.6 3.2 0.4 -0.7 0.0 -0.8 -0.4 -0.5 -0.8 0.6 0.6 -1.1 -1.3 0.3 -0.3 -0.3 0.1 0.1 -1.8 -1.1 -0.4 -0.0 -1.3 0.5 -0.6 -1.4 0.2 -0.1 0.2 -0.7 -0.1
Tense / ‘highly strung’ 4.1 6.7 15.3 3.9 -3.5 -2.9 -3.2 -2.2 -1.6 -0.8 -2.5 -1.2 0.3 -3.2 -3.7 -3.4 -3.2 -3.1 -2.7 -0.3 -0.5 -0.5 -3.6 -3.7 0.7 -3.0 -2.5 -0.1 -3.6 -2.5 1.5 -2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 3.6 5.5 10.5 1.9 -2.9 -3.1 -3.2 -2.8 -1.0 -1.0 -2.7 -3.2 -0.1 -2.3 -3.0 -2.7 -3.0 -3.1 -2.6 -1.2 -0.7 -1.8 -2.8 -2.0 -0.6 -2.6 -1.9 -1.4 -3.0 -2.9 0.3 -2.2
Hair/balding pattern: Pattern 4 0.5 1.1 3.1 0.3 -0.7 -1.3 -1.1 -0.7 -1.1 -0.2 -1.2 -1.5 1.0 0.0 -1.2 -1.1 -1.3 -1.3 -1.3 0.7 1.4 -1.6 -0.9 -1.0 0.0 -1.0 -0.8 -1.0 -1.3 -1.8 0.8 -0.3
Birth weight of first child 3.9 7.1 17.7 4.2 -3.5 -2.2 -3.5 -2.4 -1.3 0.1 -1.4 -0.8 -0.5 -4.1 -3.2 -2.3 -2.5 -2.5 -2.7 -1.1 -2.7 -0.9 -3.5 -2.9 -3.1 -2.4 -3.5 -3.8 -2.8 -2.4 1.0 -3.5
Peak expiratory flow (PEF) 2.7 6.3 13.5 2.5 -2.8 -2.8 -2.8 -3.1 -0.9 -0.1 -3.7 -2.2 0.6 -2.3 -3.3 -3.2 -3.1 -2.9 -3.0 0.6 0.6 -1.4 -3.5 -3.0 -0.6 -2.8 -2.1 -1.3 -3.3 -2.7 3.5 -2.0
Pulse wave reflection index 2.5 3.1 12.0 -3.5 2.1 1.9 2.0 1.9 0.4 1.7 1.8 1.9 1.1 2.3 2.3 1.6 2.0 1.8 1.8 1.2 1.7 -0.4 2.2 2.2 0.1 1.5 0.6 0.7 1.9 1.2 0.4 2.0
Ever highly irritable/argumentative for 2 days 0.4 0.5 2.6 1.3 -0.6 0.5 -0.2 0.4 0.2 -0.5 0.0 1.5 -1.0 -1.0 -0.1 0.0 -0.1 0.2 0.5 -1.2 -1.6 0.7 0.2 -1.0 -0.9 0.2 -0.4 0.1 0.1 0.6 0.4 0.0
Loud music exposure frequency 0.6 0.7 3.9 -0.4 0.7 0.3 0.6 -0.9 -0.3 -0.2 0.1 -0.3 -2.0 0.4 0.2 0.0 0.5 0.4 0.7 -1.6 -0.8 1.6 0.1 0.6 0.1 -0.1 1.6 1.5 0.5 1.1 -1.0 0.1
Qualifications: O levels/GCSEs or equivalent 2.4 3.8 10.7 2.8 -2.7 -1.7 -2.5 -1.3 0.5 -0.8 -1.6 -0.1 -0.1 -3.3 -2.2 -2.2 -2.1 -1.9 -1.9 -0.7 -1.4 -1.3 -2.2 -3.2 0.1 -2.1 -3.1 -2.0 -2.3 -1.9 0.8 -1.6
Mouth/teeth dental problems: Bleeding gums 1.7 2.3 7.5 -1.7 1.8 1.1 1.9 1.9 1.7 2.7 1.3 1.2 1.9 2.1 1.6 2.1 1.6 1.3 1.1 1.0 0.7 -0.3 1.8 1.8 0.2 1.5 0.9 0.7 1.6 0.9 -0.5 1.7
Blood clot in the leg (DVT) 0.9 1.1 3.6 -1.5 1.1 0.9 1.2 1.1 0.4 0.2 1.4 0.5 0.7 1.3 1.3 1.9 1.2 1.1 0.8 0.3 -0.1 0.3 1.3 0.4 -1.8 1.3 0.5 -0.6 1.5 1.1 -0.8 1.0
Medication: Paracetamol 0.6 1.1 2.9 0.7 -1.5 -0.7 -1.4 -0.8 -1.2 -1.5 0.6 0.5 -0.7 -1.7 -0.5 -0.9 -1.2 -0.9 -0.4 -1.6 -1.5 -0.5 -0.5 -1.2 -0.7 -1.5 -1.6 0.6 -0.9 -0.2 -1.0 0.4
Headache pain in last month 1.0 1.8 5.7 2.4 -1.9 -0.8 -1.4 -0.5 -1.0 -0.4 -1.3 -0.1 0.4 -1.9 -0.9 -1.3 -1.1 -1.1 -1.0 -0.5 -1.1 -1.5 -0.8 -1.7 -1.9 -1.8 -1.9 -0.7 -1.5 -0.9 2.0 -0.8
Medication for cholesterol, blood pressure or diabetes 2.4 4.0 10.6 1.8 -2.7 -2.2 -3.0 -2.0 -0.2 -2.1 -1.0 -1.4 -2.0 -2.8 -2.4 -2.4 -2.2 -2.1 -1.6 -1.1 -2.4 -1.0 -2.2 -1.7 -0.5 -1.9 -1.5 -1.6 -2.2 -1.7 -1.1 -3.3
Glaucoma (self-reported) 0.7 0.8 3.7 -0.1 1.0 0.2 0.9 0.4 1.3 -1.0 0.4 -0.1 -1.6 0.9 0.5 1.1 0.6 0.6 1.2 -0.9 0.1 1.5 0.8 0.7 -0.2 1.1 1.9 1.1 1.0 1.0 -0.2 0.1
Gout (self-reported) 0.6 0.8 2.6 -0.2 1.5 0.6 1.5 0.5 0.8 0.4 0.3 0.7 -0.3 1.0 1.0 0.7 0.8 0.9 0.8 -0.1 0.9 1.1 0.9 0.5 0.6 0.7 1.6 1.4 0.9 1.1 0.3 1.2
Hypothyroidism/myxoedema (self-reported) 2.7 5.2 17.9 3.6 -3.0 -1.6 -2.7 -2.1 -2.4 -1.3 -2.0 -0.0 -1.3 -3.3 -2.3 -2.9 -2.4 -2.0 -1.9 -2.2 -1.7 -0.1 -3.0 -4.2 -0.8 -2.5 -2.3 -0.3 -2.4 -1.1 2.2 -2.3
Medication: Amlodipine 2.3 3.3 7.8 -1.9 2.5 1.7 1.7 0.8 1.9 -0.8 1.9 1.0 -1.8 2.1 1.6 2.3 1.7 1.8 1.7 0.1 0.0 1.8 1.6 2.3 1.9 2.6 2.8 1.8 2.3 1.7 -1.6 1.3
Medication: Ventolin 100micrograms inhaler 0.4 0.5 3.9 -1.2 0.3 0.3 0.5 2.0 1.0 0.8 0.3 0.2 0.4 0.8 0.7 0.4 0.4 0.4 0.3 1.5 0.5 -0.1 0.7 0.6 0.4 0.4 0.2 0.2 0.6 0.4 -0.3 0.7
Birth weight 0.4 0.9 4.9 0.6 -0.5 -1.2 -0.7 -2.2 -1.6 0.7 -0.9 -1.5 -0.7 -0.7 -1.2 -0.8 -0.9 -1.0 -0.9 -0.7 -0.4 0.5 -1.4 -1.0 -0.1 -0.7 0.4 -0.1 -0.9 -0.6 -0.4 -0.8
Chronic bronchitis/emphysema (mother) 0.9 1.1 5.7 0.7 -1.0 0.3 -0.2 0.1 -1.1 1.2 0.7 2.4 0.8 -0.9 0.8 -0.3 0.6 0.6 0.3 0.2 -0.7 -0.3 -0.3 -1.9 -2.3 -1.3 -2.3 -0.4 0.2 0.8 0.7 0.3
High blood pressure (siblings) 1.3 1.9 6.0 -0.7 1.6 1.4 1.5 0.9 2.3 -0.2 0.7 0.8 -1.0 1.0 0.9 1.4 1.1 1.2 1.3 -0.7 0.1 2.5 0.9 1.4 1.7 1.7 1.9 2.3 1.4 1.6 -1.2 1.0
Forced vital capacity (FVC), Best measure 1.0 3.6 8.8 1.5 -1.3 -2.1 -1.8 -2.2 -0.3 0.7 -3.0 -1.6 2.0 -0.0 -1.8 -2.5 -2.0 -2.2 -2.3 2.2 2.2 -2.6 -1.7 -1.4 0.8 -2.2 -1.4 -1.6 -2.4 -2.7 1.5 -0.6
Body fat percentage 0.8 3.0 7.9 -0.8 1.6 2.3 2.1 1.7 1.1 1.8 2.6 1.7 0.4 0.9 2.2 2.8 2.4 2.4 1.8 -0.2 -0.8 1.8 1.8 1.6 -0.7 2.0 0.6 0.8 2.3 2.5 -0.8 1.5
Leg fat percentage (right) 1.4 5.0 13.8 -1.6 2.2 3.0 2.5 2.1 0.7 1.7 3.4 1.7 -0.3 1.4 2.8 3.7 3.0 3.0 2.5 -0.3 -0.9 2.3 2.6 1.8 -0.8 2.8 1.2 0.7 3.2 3.2 -0.8 2.2
Arm fat-free mass (right) 2.2 11.2 21.9 -4.1 4.7 3.3 4.4 2.8 1.2 3.8 2.6 2.0 1.4 4.7 4.1 4.5 4.3 3.8 3.2 2.3 2.4 2.1 3.7 3.7 1.4 4.5 3.7 1.5 4.4 3.1 0.4 3.0
Exposure to tobacco smoke outside home 0.9 1.2 2.4 0.4 -1.3 -1.5 -1.4 -0.8 -1.5 -0.0 -0.7 -1.0 0.5 -0.6 -1.1 -1.4 -1.4 -1.4 -1.0 -0.6 0.3 -0.9 -1.3 -1.1 -0.4 -1.4 -1.0 -1.0 -1.3 -1.4 -0.7 -1.2
Comparative body size at age 10 2.8 7.7 26.3 -5.1 3.5 2.7 3.3 1.8 -1.0 1.8 3.2 0.4 0.3 4.2 2.9 3.6 3.0 2.6 2.8 1.6 1.3 1.2 3.0 4.0 0.8 3.3 3.3 0.9 3.5 2.1 -3.3 2.0
Number of full brothers 0.6 0.8 6.2 -1.0 0.7 0.7 0.8 -0.1 -1.0 0.5 0.9 -0.0 -0.1 0.8 0.9 1.2 0.9 0.7 0.3 -0.9 -0.8 0.3 1.0 0.8 -2.5 0.3 1.0 0.6 1.0 0.9 -0.8 0.5
Worry too long after embarrassment 5.8 9.8 18.6 2.8 -4.0 -3.8 -4.3 -1.4 -0.4 -1.9 -4.1 -2.7 0.7 -2.9 -3.9 -4.3 -4.3 -4.1 -3.5 -0.5 0.5 -3.2 -3.2 -3.5 0.6 -3.6 -3.4 -2.1 -4.3 -4.2 1.8 -2.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 3.1 1.3 -1.2 -1.2 -1.7 -1.7 -0.0 -1.7 -0.5 -1.6 -1.1 -1.2 -1.1 -0.8 -1.4 -1.3 -1.0 -1.2 -1.0 -0.8 -1.1 -0.5 -0.1 -0.8 -0.6 -0.5 -1.0 -0.9 -1.1 -1.0
Wheeze or whistling in the chest in last year 1.7 3.0 8.6 -2.9 2.3 1.8 2.2 2.4 0.2 1.0 2.0 0.2 0.6 2.2 1.6 2.0 1.7 1.6 2.3 0.7 1.2 1.5 1.8 1.8 0.2 1.8 2.1 2.0 1.9 1.7 -0.6 1.5
Number of children fathered 1.1 1.2 5.0 -2.2 0.9 0.9 0.9 2.1 0.5 1.3 0.7 1.0 0.8 1.6 1.3 1.2 0.8 0.8 0.8 0.6 0.9 -0.8 1.6 1.2 -0.5 0.8 0.1 -0.4 1.2 0.4 -0.7 1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.2 0.5 -0.7 -0.9 -0.6 -0.4 0.1 -0.5 -1.5 -0.1 0.7 -0.7 -0.7 -1.0 -0.8 -0.8 -0.8 0.3 0.4 -1.1 -0.6 -0.2 0.2 -1.0 -1.0 -0.6 -1.1 -0.9 0.7 -0.8
Age at first live birth 3.0 5.4 15.2 3.9 -2.6 -2.8 -2.6 -1.6 -0.8 -0.9 -3.2 -1.9 0.3 -2.2 -2.9 -2.9 -2.5 -2.7 -3.1 -0.1 -0.0 -1.1 -2.6 -2.8 -0.0 -2.4 -1.9 -1.8 -2.9 -2.8 1.9 -2.9
Pulse wave peak to peak time 2.4 2.9 11.4 3.4 -1.6 -1.6 -1.6 -2.2 -0.2 -1.7 -0.7 -0.7 -2.4 -2.2 -2.2 -1.5 -1.6 -1.4 -0.8 -1.9 -2.3 2.1 -2.3 -1.9 0.2 -1.4 0.1 0.6 -1.6 -0.2 -1.1 -2.0
Health satisfaction 2.0 2.6 5.6 -1.8 1.8 1.7 1.8 2.1 0.8 2.2 -0.1 1.4 2.3 2.2 1.7 2.2 1.6 1.6 1.0 1.8 1.7 -0.5 2.1 1.2 -0.2 1.8 0.9 -0.6 1.5 0.7 0.7 2.4
Shortness of breath walking on level ground 1.3 1.6 4.8 -1.2 1.1 1.6 1.8 1.4 -0.1 1.4 1.0 1.8 0.5 1.1 1.3 1.3 1.7 1.5 1.5 0.7 -0.1 0.9 1.5 -0.0 0.7 1.3 0.7 2.2 1.5 1.4 -0.1 1.2
Qualifications: College or University degree 0.6 1.9 4.2 0.7 -1.9 -1.4 -1.5 -1.0 -1.3 1.1 -1.7 -1.0 0.4 -1.9 -1.4 -1.7 -1.1 -1.4 -1.5 0.2 -0.8 -1.1 -1.5 -1.5 -1.3 -1.7 -2.0 -1.5 -1.5 -1.4 1.5 -1.1
Eye problems/disorders: None of the above 0.4 0.4 2.5 0.6 -0.2 0.6 0.2 0.3 -0.4 1.6 0.3 1.3 -0.2 0.1 0.1 0.4 0.5 0.4 0.8 -1.1 -0.4 0.9 0.1 -0.2 -0.4 -0.0 0.1 1.5 0.3 0.4 0.0 0.7
Mouth/teeth dental problems: Loose teeth 3.4 4.1 8.7 -1.6 1.7 2.9 2.1 1.6 0.9 1.9 2.3 2.5 -0.8 0.9 2.4 2.9 2.6 2.6 2.6 -1.5 -1.6 1.5 2.2 1.6 -0.9 2.3 0.8 1.8 2.6 3.0 -0.9 2.1
Emphysema/chronic bronchitis 4.2 4.7 9.2 -2.1 2.6 3.0 2.6 2.5 -1.0 2.2 2.3 1.3 -0.2 2.4 2.5 2.9 2.8 2.6 2.5 0.5 0.7 1.8 2.7 2.1 -0.4 2.5 2.0 1.0 2.9 2.7 -0.6 2.4
Medication for pain relief, constipation, heartburn 0.4 0.8 3.4 -0.2 1.4 0.2 0.9 0.4 1.8 0.6 -0.4 -0.5 -0.1 1.3 -0.2 0.2 0.6 0.4 0.3 1.3 1.2 1.0 -0.0 1.4 1.1 1.1 1.9 -0.4 0.4 0.1 0.4 -0.6
Neck or shoulder pain in last month 1.3 1.8 9.4 0.8 -1.1 -0.1 -1.2 -1.5 -3.1 -1.1 1.9 0.5 -2.5 -1.5 -0.0 0.3 -0.3 0.0 0.2 -2.9 -2.6 0.1 -0.2 -1.4 -1.4 -0.5 -0.9 0.1 0.2 0.7 -1.6 -0.4
Medication: Blood pressure 3.9 6.9 15.3 -3.3 3.4 3.3 3.6 2.1 0.6 1.4 2.5 1.9 0.6 3.3 3.3 3.4 3.0 3.1 2.7 0.8 1.8 1.8 3.1 3.0 1.0 2.7 2.2 2.2 3.3 2.8 -0.7 3.9
Angina (self-reported) 0.5 0.6 1.9 -0.9 0.6 0.9 0.4 1.4 -0.8 0.7 0.9 0.6 1.1 0.8 0.9 1.4 0.7 0.8 0.4 0.7 0.9 -0.5 1.1 0.5 -0.6 1.0 -0.3 -0.8 0.9 0.7 -0.0 0.6
Migraine (self-reported) 0.4 0.5 2.0 -0.1 -0.0 0.3 0.5 1.2 1.4 1.4 0.2 1.0 1.3 0.4 0.6 -0.0 0.5 0.2 0.9 0.9 1.1 -0.4 0.4 0.1 0.3 -0.3 -0.5 1.1 0.1 0.3 0.8 0.7
Medication: Ibuprofen 1.6 2.0 5.7 0.9 -2.1 -0.8 -1.9 -1.0 -1.8 -1.9 1.1 0.7 -1.6 -2.1 -0.5 -0.7 -1.1 -0.7 -0.5 -2.2 -2.4 -1.0 -0.4 -1.9 -1.6 -1.5 -2.3 -0.3 -0.9 -0.3 -1.2 -0.9
Medication: Allopurinol 1.9 2.6 6.1 -0.9 2.1 1.8 2.3 1.1 0.4 1.3 1.3 1.5 -0.7 1.4 1.8 1.7 1.9 1.9 2.1 -0.2 0.5 1.9 1.9 1.3 0.1 1.4 2.1 2.5 1.8 2.1 0.4 2.1
Medication: Omeprazole 0.1 0.2 1.3 -1.1 0.2 0.3 0.1 -0.2 -0.1 0.2 0.3 -0.9 -0.5 0.4 0.3 0.2 0.5 0.4 0.4 -0.8 0.2 0.1 0.0 -0.1 0.1 0.1 0.1 0.0 0.5 0.1 -0.4 0.6
Medication: Seretide 50 evohaler 0.7 0.8 3.2 -0.9 -0.6 -0.9 -0.5 0.9 -1.5 0.6 -0.4 -1.1 0.7 0.3 -0.9 -0.9 -1.0 -1.1 -1.1 0.6 1.1 -0.9 -0.7 -0.7 -1.0 -0.9 -0.6 -1.8 -0.7 -1.3 0.1 -0.6
Mean time to correctly identify matches 0.2 0.5 2.6 0.8 0.1 0.4 0.1 -0.7 -0.4 -1.1 0.8 1.0 -1.3 -0.3 0.5 -0.0 0.4 0.4 0.2 -0.7 -1.3 0.1 0.4 0.0 0.8 -0.2 0.3 0.2 0.4 0.7 -1.6 0.3
Heart disease (mother) 0.6 0.7 2.1 -1.0 0.1 0.8 -0.0 1.3 0.7 0.3 0.1 0.1 0.8 0.2 1.3 1.3 0.7 0.9 0.1 -0.9 0.2 -0.9 1.4 -0.1 0.9 1.5 -0.9 -0.2 0.9 0.3 0.6 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 5.4 6.5 16.2 1.5 -3.4 -2.4 -3.4 -2.4 -2.7 -1.8 -1.5 -1.7 -1.9 -4.0 -2.9 -2.3 -3.1 -2.7 -2.3 -2.4 -3.0 -1.3 -2.7 -3.4 -2.7 -2.5 -2.6 -1.9 -2.8 -1.7 -0.1 -3.0
Whole body fat mass 1.4 6.0 14.7 -2.1 2.8 3.0 3.2 2.2 1.2 2.7 3.0 1.9 0.7 2.2 3.1 3.8 3.4 3.2 2.5 0.5 0.0 2.2 2.7 2.6 -0.3 3.2 1.7 1.1 3.3 3.0 -0.5 2.2
Leg fat mass (right) 2.3 8.8 21.8 -2.9 3.4 3.6 3.7 2.6 1.3 2.8 3.7 1.9 0.6 2.9 3.8 4.7 4.0 3.8 3.1 0.6 0.1 2.4 3.4 3.3 -0.4 3.9 2.3 1.2 4.2 3.6 -0.7 2.8
Arm predicted mass (right) 2.6 13.1 24.7 -4.6 4.9 3.7 4.7 3.2 1.3 3.9 2.8 2.1 1.5 5.0 4.5 4.8 4.6 4.0 3.5 2.4 2.5 2.1 4.1 4.0 1.8 4.9 3.9 1.8 4.8 3.2 0.3 3.2
Pulse rate, automated reading 1.9 6.1 12.7 1.6 -2.6 -3.3 -2.4 -2.1 -0.9 0.6 -2.8 -3.6 1.2 -1.6 -3.0 -2.5 -3.0 -3.2 -3.1 0.4 -0.3 -2.4 -2.7 -1.4 -3.5 -3.1 -1.6 -3.4 -3.1 -3.2 0.2 -2.4
Alcohol intake frequency. 0.8 1.9 7.8 -0.5 2.1 1.5 1.8 0.5 0.9 0.9 0.8 1.5 0.3 1.7 1.6 1.2 1.7 1.6 0.9 0.3 0.1 0.8 1.5 0.7 0.5 0.9 1.9 2.8 1.4 2.0 0.2 1.9
Comparative height size at age 10 0.6 3.3 12.7 -2.6 2.8 1.3 1.8 0.9 2.5 0.6 -0.6 -0.2 -0.6 2.5 1.1 1.8 1.7 1.6 1.1 0.6 1.6 1.0 1.8 2.6 2.4 2.8 3.6 2.7 1.4 1.3 0.5 1.1
Number of full sisters 1.5 1.8 6.7 -2.0 1.7 1.0 1.6 1.7 1.4 0.6 0.7 -0.3 -0.6 2.1 1.6 1.4 1.3 1.1 1.3 0.6 0.7 0.3 1.7 2.6 -0.9 1.2 1.9 0.9 1.7 1.0 -0.2 0.8
Suffer from ‘nerves’ 5.5 8.7 15.5 3.4 -3.8 -3.5 -3.9 -2.5 -1.6 -2.5 -2.8 -2.2 -0.3 -2.9 -3.4 -3.9 -3.6 -3.5 -2.8 -0.1 -0.2 -2.6 -3.4 -3.3 -1.1 -3.7 -3.4 -2.2 -3.8 -3.3 1.8 -3.5
Overall health rating 1.3 2.7 6.8 -1.8 1.7 2.2 1.9 0.9 -1.3 1.4 2.2 1.3 -0.3 1.4 1.6 2.6 1.8 1.8 1.8 0.3 -0.4 1.2 2.0 2.0 -1.6 2.0 1.4 0.3 2.1 1.8 -1.4 1.9
Chest pain or discomfort 1.1 1.5 3.7 0.8 -1.1 -1.3 -1.4 -0.5 -1.6 -0.9 -1.0 -1.4 0.2 -0.9 -1.2 -1.7 -1.6 -1.5 -1.9 -0.0 0.2 -1.7 -1.0 -0.8 -1.1 -1.8 -1.2 -1.5 -1.6 -1.3 0.3 -1.4
Had major operations 0.2 0.2 0.8 -0.6 0.2 0.1 0.3 0.5 -0.4 0.4 0.6 0.8 0.6 0.7 0.5 0.0 0.1 0.1 -0.2 0.9 0.1 -0.5 0.3 -0.2 -0.1 -0.3 -0.3 0.1 0.4 0.2 -0.8 0.8
Age at last live birth 5.6 8.1 17.0 4.1 -3.1 -3.0 -3.2 -3.1 -2.5 -1.5 -3.3 -2.3 0.1 -2.9 -3.7 -3.7 -3.3 -3.3 -3.5 -0.4 -0.3 -0.8 -3.8 -3.8 -0.0 -3.3 -2.1 -1.6 -3.8 -3.1 0.9 -3.7
Family relationship satisfaction 0.5 0.6 6.5 1.0 0.3 0.3 0.2 0.8 0.1 0.1 -1.4 -0.5 1.3 0.6 -0.0 0.1 -0.1 -0.1 -0.4 0.6 1.4 -0.2 0.4 0.0 1.1 0.9 0.5 -0.4 0.0 -0.7 2.5 0.3
Leg pain on walking 2.3 2.8 7.1 -2.7 1.8 1.6 1.6 2.1 -0.6 1.7 1.3 1.9 1.4 2.4 2.4 2.0 2.0 1.9 1.5 1.5 1.0 -0.3 2.6 1.9 0.3 1.9 1.0 0.4 2.0 1.3 -1.1 1.2
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 1.6 1.3 0.1 0.2 0.4 -0.2 -0.1 0.9 -0.1 0.8 -0.2 -0.1 -0.0 -0.3 0.2 0.2 0.2 0.9 -0.1 0.6 -0.2 -0.1 0.2 -0.2 0.5 0.5 -0.1 0.4 0.4 -0.4
Commuting to job workplace: Car/motor vehicle 0.3 0.3 2.4 1.3 -0.6 -0.5 -0.5 -0.6 0.0 -0.2 0.7 -0.0 -0.7 -0.4 -0.3 -0.2 -0.3 -0.3 -0.2 -0.8 -1.1 0.3 -0.5 0.1 0.2 -0.4 -0.1 -0.4 0.0 -0.0 -1.5 -0.5
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.9 -0.3 1.4 1.2 1.3 0.0 -0.4 0.1 1.7 1.0 -0.8 0.8 1.2 1.2 1.4 1.3 1.5 0.1 -0.1 1.6 0.7 0.6 0.9 1.0 1.4 0.8 1.4 1.2 -1.0 0.5
Medication: Aspirin 1.1 1.4 3.5 -1.5 1.3 1.6 1.5 0.6 -0.2 0.7 0.8 0.7 -0.4 0.8 1.6 1.9 1.8 1.7 1.1 -0.1 -0.1 0.9 1.5 0.9 0.6 1.5 0.8 1.3 1.5 1.7 -0.6 1.2
Supplements: Vitamin C 2.9 3.4 8.3 -2.9 1.6 2.1 1.7 2.2 0.1 0.7 2.1 2.6 -0.3 0.9 2.4 2.7 2.1 2.4 1.6 -1.0 -0.9 0.3 2.9 1.8 -0.5 1.7 0.4 0.8 2.2 2.4 -1.2 2.7
Knee pain experienced in last month 0.3 0.5 3.2 -0.9 -0.0 0.6 -0.3 0.5 -1.1 -0.6 1.5 0.5 -0.7 0.1 0.6 0.8 0.4 0.4 1.2 -0.5 -0.6 -0.5 0.7 0.7 -0.3 0.3 -0.3 -0.2 0.5 0.3 -1.8 -0.3
Hypertension (Self-reported) 8.9 24.7 46.9 -4.8 6.3 5.7 6.2 4.0 2.2 2.2 4.5 4.6 -1.3 5.2 5.8 6.8 6.0 6.1 5.5 0.6 1.1 4.7 5.7 5.5 2.7 6.6 5.2 4.8 6.4 6.0 -2.5 5.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 1.1 -0.4 -0.5 -0.4 -0.5 -0.4 -0.5 1.0 0.2 0.2 0.1 0.1 -0.1 0.0 -0.1 -0.3 0.0 -0.2 0.0 -0.1 -0.5 -0.3 -0.9 -0.6 -0.7 0.0 -0.0 -0.2 -0.0 0.4
Illnesses of father: Heart disease 0.2 0.3 2.6 -1.0 0.1 0.4 0.2 0.4 0.3 0.5 0.2 0.6 0.5 -0.1 -0.1 0.0 0.1 0.1 0.9 0.7 0.3 0.8 -0.1 0.5 1.0 0.3 0.2 1.6 -0.2 -0.1 -0.5 0.2
Illnesses of siblings: Diabetes 2.5 3.0 7.6 -1.1 1.7 1.9 2.2 2.4 0.9 1.5 1.7 2.8 -0.1 1.5 1.7 2.1 1.9 1.9 1.8 0.8 -0.1 1.6 2.0 2.1 0.5 1.6 1.5 2.4 1.9 2.2 -0.5 2.2
Smoking status: Previous 1.9 2.8 8.2 -1.4 -0.2 2.1 0.2 -0.1 -2.0 -0.9 2.2 1.9 -2.2 -1.8 1.9 2.1 1.4 2.0 1.7 -2.8 -2.9 1.1 1.4 -0.2 -0.8 1.3 -1.5 0.9 1.7 2.5 -1.0 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 9.1 1.3 0.0 -0.3 -0.2 0.5 3.0 0.2 -1.1 -0.2 0.9 0.1 -0.4 -0.2 -0.0 -0.0 -0.5 0.6 0.7 -0.1 -0.2 0.2 0.7 0.2 0.2 0.1 -0.3 -0.1 1.8 0.5
Whole body fat-free mass 1.8 10.5 19.7 -4.3 4.4 3.3 4.2 2.4 1.3 3.5 2.4 1.6 1.2 4.4 4.0 4.4 4.2 3.6 3.2 2.0 2.2 1.8 3.6 3.9 1.5 4.4 3.6 1.6 4.3 2.9 0.1 3.0
Leg fat-free mass (right) 2.0 10.7 20.1 -4.3 4.4 3.4 4.4 2.2 1.3 3.8 2.5 1.5 1.5 4.5 4.0 4.3 4.3 3.6 3.1 2.2 2.1 1.7 3.6 4.4 1.3 4.3 3.4 1.6 4.3 2.8 -0.3 2.7
Arm fat percentage (left) 1.6 6.5 15.6 -2.4 2.6 3.3 3.1 2.4 1.5 2.0 3.6 1.9 0.3 1.9 3.3 3.9 3.5 3.4 2.8 -0.0 -0.5 2.2 2.9 2.7 0.1 3.1 1.3 1.0 3.5 3.2 -1.6 2.3
Average weekly red wine intake 0.3 0.5 1.4 -1.1 0.8 0.6 0.7 -0.1 -0.3 -0.5 0.2 0.5 0.6 0.9 0.9 1.0 0.8 0.7 1.2 0.6 0.7 0.2 1.0 1.0 0.4 0.5 0.4 0.5 0.8 0.5 -0.5 0.9
Handedness (chirality/laterality): Left-handed 1.1 1.3 5.6 0.1 0.3 0.7 0.4 -2.3 -2.4 -0.8 0.9 0.7 -2.3 -0.7 0.1 0.5 0.5 0.7 0.5 -1.3 -2.2 1.9 -0.1 -0.1 -1.6 0.1 0.9 1.0 0.7 1.6 -0.7 -0.0
Mood swings 3.3 5.9 14.5 3.8 -2.4 -2.8 -2.2 -2.6 -0.9 -0.1 -3.6 -1.6 1.0 -2.3 -3.2 -3.2 -2.7 -2.7 -2.8 0.1 0.3 -0.5 -3.4 -3.4 -0.3 -2.6 -1.8 -0.5 -3.0 -2.2 3.7 -2.2
Loneliness, isolation 2.3 3.2 8.0 0.5 -1.7 -2.5 -2.2 -2.0 -1.5 -1.6 -2.0 -2.3 0.4 -1.6 -2.0 -1.7 -2.4 -2.3 -2.8 -0.2 -0.6 -2.2 -2.0 -1.2 -0.7 -1.6 -1.3 -1.6 -2.3 -2.0 -0.1 -1.9
Long-standing illness, disability or infirmity 0.8 1.2 5.3 0.1 0.3 1.5 1.2 1.3 -0.0 1.9 1.5 2.3 1.1 0.3 1.2 1.0 1.3 1.1 1.7 -0.1 0.1 0.9 1.0 -0.5 0.2 0.8 -0.5 1.1 1.2 1.0 -0.1 1.0
Ever had bowel cancer screening 0.4 0.5 3.3 0.3 0.5 0.0 0.4 0.7 1.7 0.7 -0.7 0.0 0.2 0.6 -0.3 -0.3 0.0 -0.0 0.1 0.9 1.2 0.4 -0.3 -0.1 1.1 0.5 0.8 1.1 0.0 -0.2 1.8 -0.2
Diabetes diagnosed by doctor 1.5 2.5 5.6 -0.8 1.4 2.0 1.8 1.9 0.3 2.4 2.0 1.9 0.6 1.1 1.8 2.2 2.3 2.1 2.0 0.5 0.3 1.4 1.8 1.5 0.7 2.1 0.6 1.1 1.9 1.6 -0.3 1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 3.9 -1.1 1.2 1.2 1.0 0.7 -1.0 0.6 1.9 0.5 -1.1 0.6 1.1 2.0 1.1 1.2 0.8 -0.5 -1.0 1.0 1.2 1.1 -1.4 1.0 1.1 0.4 1.5 1.7 -1.4 1.3
Friendships satisfaction 0.3 0.4 2.6 0.3 0.3 0.7 -0.1 1.2 0.3 0.0 0.4 0.3 0.6 0.5 0.7 0.6 0.4 0.6 -0.1 0.1 0.1 -1.1 1.3 0.3 -0.4 0.7 -0.2 -1.6 0.4 -0.0 0.2 0.2
Qualifications: nursing, teaching 2.7 4.2 10.7 1.6 -2.5 -2.2 -2.7 -1.6 -0.9 -0.7 -1.9 -1.8 0.6 -1.9 -2.2 -3.0 -2.5 -2.6 -2.6 0.3 -0.5 -1.8 -1.9 -1.7 -1.6 -3.3 -1.9 -2.6 -2.8 -2.6 -0.3 -2.2
Commuting to job workplace: Walk 0.1 0.1 1.6 -0.5 0.2 0.2 0.2 0.5 -0.8 -0.5 0.3 0.4 0.3 0.1 -0.0 0.0 0.1 -0.0 0.2 0.2 -0.2 0.2 0.4 0.1 -1.3 -0.2 -0.1 0.2 0.1 0.2 -0.0 -0.3
Eye problems/disorders: Cataract 1.0 1.2 2.8 0.5 -1.5 -1.3 -1.5 -1.3 -0.3 -0.7 -0.8 -1.3 -0.7 -1.7 -1.1 -1.1 -1.5 -1.4 -1.3 0.0 -0.8 -1.0 -1.3 -0.6 -0.3 -0.4 -1.0 -1.6 -1.2 -1.3 0.3 -1.2
Mouth/teeth dental problems: Mouth ulcers 2.1 3.4 9.3 2.8 -2.1 -1.6 -1.6 -1.7 -2.7 0.5 -1.0 -0.2 -0.0 -2.1 -1.9 -1.9 -1.8 -1.9 -2.2 -1.9 -1.4 -0.8 -2.2 -3.0 -2.2 -2.4 -1.9 -1.2 -2.0 -1.3 1.3 -1.6
Medication for cholesterol 5.2 7.8 17.7 1.9 -2.9 -3.1 -3.1 -2.1 -1.4 -1.8 -3.5 -3.9 1.3 -2.3 -3.4 -3.5 -3.6 -3.7 -3.4 0.1 0.4 -3.1 -2.9 -2.7 -0.8 -3.2 -2.2 -2.5 -3.9 -4.2 1.5 -2.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 4.1 -1.1 -0.2 -0.4 -0.3 0.5 0.2 -0.3 1.6 0.3 0.5 0.5 0.6 0.3 -0.2 -0.1 0.0 -0.2 -0.3 -1.1 0.3 -0.1 -2.0 -0.9 -0.7 -0.4 0.4 0.2 -0.5 1.1
Back pain experienced in last month 0.4 0.6 5.7 -0.3 -0.7 0.0 -0.3 -1.0 -2.4 0.2 0.7 0.4 -0.1 -0.6 -0.4 0.5 -0.3 -0.2 0.4 -1.2 -0.7 0.5 -0.3 -0.4 -2.0 0.1 -0.5 -0.1 0.0 0.3 -0.4 0.3
Mineral and other dietary supplements 4.5 6.0 11.6 2.4 -2.6 -2.7 -2.3 -2.1 -2.3 0.4 -3.4 -2.9 1.9 -1.7 -2.9 -3.4 -2.6 -3.0 -2.9 0.3 0.3 -1.6 -2.8 -2.4 -1.5 -3.0 -1.8 -1.8 -3.1 -2.8 3.1 -2.8
Breast cancer (self-reported) 0.7 0.8 4.2 -0.0 -0.6 -1.0 -0.4 -0.1 -0.6 0.4 0.1 -0.2 1.8 0.5 -0.5 -0.7 -0.7 -1.0 -1.1 0.9 0.7 -1.4 -0.6 -0.7 -2.1 -1.2 -0.8 -1.1 -0.6 -1.2 0.1 -0.7
Asthma (self-reported) 0.4 0.7 6.9 -1.0 0.2 0.3 0.4 0.9 0.2 -0.2 1.9 0.4 -1.2 0.3 0.5 0.4 0.4 0.5 1.1 0.1 -1.1 0.8 0.4 0.3 -0.0 -0.2 0.5 0.8 0.8 1.0 -2.6 0.7
Osteoporosis (self-reported) 1.5 1.8 5.1 1.8 -1.6 -1.7 -1.6 -1.2 -1.0 -0.1 -0.8 -0.5 1.1 -1.1 -1.2 -2.2 -1.5 -1.4 -1.3 -0.3 -0.0 -1.2 -1.6 -2.2 -0.3 -2.3 -1.7 -0.8 -1.7 -1.4 0.4 -1.0
Osteoarthritis (self-reported) 0.8 1.0 4.4 -1.1 -0.6 0.6 -0.4 0.4 -1.0 -0.4 2.0 1.2 -0.6 -0.5 1.2 1.4 0.4 0.7 0.8 -0.9 -1.6 -0.2 0.9 -0.4 -2.1 0.5 -1.5 -1.3 1.1 0.8 -1.2 -0.0
Medication: Aspirin 1.0 1.2 3.3 -1.8 1.2 1.5 1.3 0.6 -0.5 0.9 0.7 0.8 0.1 0.8 1.6 1.8 1.6 1.6 1.0 -0.1 0.1 0.4 1.5 0.7 0.6 1.3 0.4 1.0 1.4 1.4 -0.8 1.2
Medication: Gliclazide 1.4 1.6 3.7 -0.8 0.7 1.9 1.1 1.6 1.2 1.4 1.7 1.2 0.6 0.7 1.6 1.8 1.7 1.7 1.8 -0.2 0.4 0.9 1.4 0.9 0.9 1.6 -0.2 0.3 1.5 1.1 -0.2 1.6
Illnesses of father: None of the above (group 1) 1.5 1.9 6.0 1.2 -0.9 -1.4 -1.4 -0.7 -1.2 -0.4 -2.4 -1.5 0.3 -0.8 -1.2 -1.6 -1.3 -1.4 -2.4 -0.2 0.2 -1.8 -0.9 -0.9 -1.3 -1.3 -0.6 -2.4 -1.5 -1.3 2.1 -1.2
Smoking status: Current 2.0 3.2 11.2 -2.4 2.1 1.6 1.7 2.1 0.9 0.0 2.1 -0.2 -0.5 2.1 1.9 2.3 2.0 1.8 2.3 0.8 0.3 1.0 2.7 3.4 -0.6 2.3 2.2 0.1 2.2 1.6 -1.5 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.7 7.7 15.8 3.4 -3.0 -3.2 -2.8 -2.9 -1.0 0.9 -3.9 -2.1 1.9 -1.3 -3.4 -4.0 -3.1 -3.5 -3.3 1.3 1.4 -2.4 -3.5 -2.1 -0.9 -3.3 -2.2 -2.7 -3.7 -3.6 2.4 -2.9
Whole body water mass 1.8 10.3 19.5 -4.3 4.4 3.2 4.2 2.5 1.5 3.5 2.3 1.5 1.2 4.4 3.9 4.3 4.1 3.6 3.1 2.1 2.2 1.7 3.6 3.9 1.6 4.4 3.5 1.5 4.2 2.7 0.2 2.8
Leg predicted mass (right) 2.0 10.8 20.2 -4.2 4.4 3.5 4.5 2.3 1.3 3.8 2.5 1.6 1.5 4.5 4.1 4.4 4.3 3.7 3.2 2.3 2.1 1.8 3.6 4.4 1.3 4.3 3.4 1.6 4.3 2.8 -0.2 2.7
Arm fat mass (left) 2.2 9.0 21.0 -3.4 3.6 3.6 3.9 2.7 1.7 2.7 3.7 1.9 0.9 2.9 3.9 4.6 4.1 3.8 3.2 0.7 0.4 2.2 3.4 3.4 0.2 3.9 2.1 1.2 4.1 3.5 -1.1 2.6
Number of self-reported non-cancer illnesses 0.3 0.5 2.7 0.2 0.1 0.2 0.6 0.8 0.1 0.8 0.7 1.7 -0.5 0.0 0.6 0.7 0.4 0.5 0.2 -0.9 -0.5 0.9 0.1 -0.9 -0.2 0.2 -0.2 1.0 0.7 1.2 -0.9 0.6
Average weekly champagne plus white wine intake 0.2 0.3 1.9 0.2 -0.1 0.3 -0.0 0.7 0.8 1.4 0.5 0.8 0.8 0.2 0.6 0.3 0.5 0.4 -0.3 1.1 0.0 -0.4 0.1 0.2 0.2 0.1 -1.0 -1.0 0.4 -0.1 -0.1 0.5
Miserableness 6.4 11.2 20.4 4.0 -3.7 -4.5 -4.1 -2.3 -0.6 -1.6 -4.1 -3.0 0.6 -3.6 -4.4 -4.3 -4.4 -4.2 -4.2 -1.0 -0.1 -2.3 -4.0 -4.5 0.7 -3.5 -3.1 -2.2 -4.4 -3.8 2.1 -3.1
Guilty feelings 7.6 11.5 24.1 3.9 -3.8 -4.2 -4.3 -2.0 -1.2 -2.5 -4.1 -3.3 0.2 -3.4 -4.1 -4.9 -4.7 -4.4 -4.2 -1.1 -0.1 -2.7 -3.5 -4.0 0.1 -4.1 -2.9 -2.5 -4.6 -4.1 1.2 -3.0
Wears glasses or contact lenses 1.8 2.1 6.3 1.6 -1.8 -1.6 -1.8 -0.9 -0.0 0.9 -1.1 -0.4 1.5 -1.3 -1.2 -1.3 -1.5 -1.4 -1.8 1.3 0.3 -1.7 -1.3 -1.9 -0.3 -1.3 -2.5 -2.1 -1.7 -1.9 1.1 -0.7
Ever taken oral contraceptive pill 1.0 1.1 3.7 1.8 -1.6 -0.9 -1.3 -0.9 0.0 0.0 -0.9 -0.3 -0.5 -1.9 -0.9 -0.4 -0.9 -0.8 -0.8 -1.6 -1.2 -0.2 -0.8 -1.1 -1.3 -0.9 -1.8 -1.1 -0.8 -0.4 0.8 -0.4
Hearing aid user 0.4 0.5 3.7 0.2 -0.1 0.7 -0.2 0.1 -1.9 -0.1 1.6 1.3 -0.4 -0.0 0.1 0.0 -0.0 0.1 0.5 -0.8 -0.3 0.1 0.0 -1.0 0.1 -0.5 -0.5 0.1 0.1 0.2 -1.6 0.3
Mother’s age at death 0.4 0.5 1.8 0.9 -0.8 -0.5 -0.8 0.3 1.3 -0.2 -0.3 -0.1 0.2 -0.3 -0.5 -1.1 -0.6 -0.5 -0.4 0.7 0.4 -1.2 -0.4 -0.1 0.5 -0.9 -0.7 -0.6 -0.9 -0.9 1.0 0.2
Financial situation satisfaction 2.0 2.5 5.2 -1.5 1.9 1.6 2.0 1.8 1.6 1.8 0.1 1.1 1.2 2.3 2.0 1.4 1.9 1.7 1.6 1.9 1.8 0.2 2.0 1.6 1.1 1.6 1.2 0.8 1.8 1.1 1.1 1.7
Tinnitus: Yes, now most or all of the time 1.8 2.0 5.1 0.6 -1.8 -1.4 -1.8 -2.2 -2.2 -1.0 -0.8 -1.1 -0.2 -0.8 -1.6 -1.5 -1.7 -1.7 -1.6 -0.2 -0.5 -1.6 -1.5 -1.4 -2.0 -1.8 -1.3 -1.3 -1.4 -1.5 0.3 -1.3
Commuting to job workplace: Public transport 0.8 1.0 2.6 0.3 -0.4 -0.8 -0.2 -0.2 -0.4 -1.3 -1.6 -1.5 0.8 0.1 -1.2 -1.3 -1.1 -1.3 -0.9 1.0 1.5 0.1 -0.9 -0.5 1.0 -0.6 0.4 0.8 -1.2 -1.5 1.3 -1.0
Eye problems/disorders: Glaucoma 0.3 0.4 2.0 -0.8 0.8 0.0 0.7 0.1 0.0 -0.1 0.2 -0.4 -0.7 1.1 0.3 0.8 0.4 0.2 0.9 -0.4 0.4 0.7 0.5 0.4 -0.9 0.6 1.4 0.3 0.7 0.4 -0.7 -0.2
Medication: Blood pressure 9.8 18.6 34.7 -4.4 5.4 4.8 5.1 4.1 3.4 1.9 4.1 4.0 -1.2 4.5 4.9 5.6 5.1 5.2 4.9 0.9 1.0 3.9 5.0 5.2 3.2 5.9 4.5 3.4 5.6 5.0 -1.9 4.2
Pain type(s) experienced in last month: Hip pain 0.9 1.1 7.4 -1.3 -1.1 -0.5 -0.9 -0.2 -2.1 -0.4 1.7 0.4 0.0 -0.5 0.0 0.5 -0.7 -0.4 -0.2 -1.8 -0.9 -1.3 0.1 -0.9 -1.7 -0.6 -1.4 -0.9 -0.0 -0.3 -2.7 0.5
Supplements: Fish oil (including cod liver oil) 3.3 4.3 16.0 -2.2 2.3 2.1 1.9 0.9 1.2 -0.3 2.9 2.4 -1.3 1.4 2.4 3.0 2.1 2.5 2.2 -0.5 -0.5 1.2 2.0 1.7 1.4 2.1 1.3 2.2 2.5 2.5 -4.0 2.6
High cholesterol (Self-reported) 0.3 0.5 2.0 -0.2 1.2 0.6 1.0 0.6 -0.8 0.2 0.3 0.5 -0.2 1.0 0.5 0.8 0.5 0.8 0.5 -0.4 0.4 1.1 0.6 -0.1 -0.0 0.4 1.1 0.9 0.8 1.4 -0.4 0.7
Medication: Bendroflumethiazide 8.7 13.3 32.9 -5.7 4.1 4.2 4.0 3.0 1.6 1.2 4.1 3.3 -0.2 4.0 4.6 4.9 4.1 4.2 4.3 1.4 0.7 1.7 4.5 4.6 2.2 4.7 2.8 2.6 4.7 3.7 -2.4 4.2
Medication: Paracetamol 1.0 1.5 5.9 0.6 -1.4 -0.5 -1.4 -0.7 -1.4 -2.0 1.0 0.2 -1.9 -1.7 -1.0 -1.0 -1.4 -1.0 -0.0 -2.4 -1.6 0.3 -0.8 -1.2 0.2 -1.3 -0.9 1.0 -0.9 -0.2 -2.1 0.1
Medication: Lisinopril 3.0 3.9 9.5 -1.2 2.1 2.8 1.8 1.9 0.9 -0.0 2.6 1.9 -0.5 1.5 2.9 2.6 2.5 2.7 2.2 -0.4 -0.2 0.9 2.9 2.2 0.5 1.9 1.0 1.1 2.6 2.6 -0.9 3.1
Medication: Atorvastatin 0.3 0.3 2.9 0.9 -0.6 -0.2 -0.5 0.5 -0.8 -0.4 1.7 0.8 -0.2 -0.6 -0.3 0.3 -0.3 0.1 0.2 -0.5 -0.5 0.4 -0.3 -0.9 -0.3 -0.1 -0.6 -0.4 -0.0 0.2 -0.6 0.6
Illnesses of father: High blood pressure 0.8 1.0 3.7 -1.1 0.8 1.1 1.0 0.3 0.9 0.7 1.7 1.3 0.5 0.6 1.3 1.4 1.2 1.1 1.5 0.3 -0.1 0.5 0.6 0.2 0.5 0.8 -0.2 1.2 1.2 0.9 -1.9 0.7
Alcohol drinker status: Never 0.4 0.5 2.2 -0.0 0.2 0.6 0.1 0.2 0.9 -0.5 1.0 1.1 0.1 0.0 1.3 0.5 0.6 0.9 0.1 0.1 -0.7 -1.4 1.0 -0.3 0.1 -0.4 -0.7 -0.3 0.4 0.7 -0.6 1.5
Ever smoked 0.7 1.1 5.0 -0.2 -0.4 0.6 -0.4 -0.5 -2.2 -1.3 1.5 -0.1 -2.0 -1.3 0.6 0.3 0.2 0.5 0.7 -2.2 -1.8 0.7 0.3 -0.2 -2.1 -0.2 -0.9 0.1 0.5 1.2 -0.6 -0.6
Basal metabolic rate 1.9 10.3 19.4 -4.2 4.3 3.4 4.2 2.5 1.5 3.4 2.5 1.6 1.2 4.3 4.0 4.4 4.2 3.6 3.2 1.9 1.9 1.8 3.6 3.9 1.3 4.3 3.4 1.5 4.3 2.9 -0.1 2.9
Leg fat percentage (left) 1.3 4.8 12.5 -1.4 2.2 3.0 2.5 2.2 0.6 1.9 3.2 1.9 0.2 1.7 2.8 3.5 3.0 3.0 2.4 0.0 -0.6 2.0 2.5 2.0 -0.9 2.5 1.1 0.7 3.1 3.1 -0.8 2.0
Arm fat-free mass (left) 2.3 11.5 22.4 -4.4 4.6 3.5 4.4 2.9 1.4 3.3 2.8 2.0 1.3 4.5 4.4 4.7 4.4 3.9 3.4 2.0 2.0 1.8 3.9 3.8 1.2 4.7 3.4 1.6 4.6 3.2 0.2 2.9
Number of operations (self-reported) 0.6 0.9 3.2 -1.7 0.6 0.9 0.7 1.0 -0.2 1.0 1.8 0.8 0.2 1.2 1.3 1.4 0.9 0.7 0.5 0.4 0.1 -0.3 0.9 0.8 -1.0 0.8 -0.2 -0.4 1.4 0.8 -1.2 0.8
Average weekly beer plus cider intake 3.4 4.9 11.2 1.9 -3.0 -2.6 -2.8 -1.3 -1.0 -2.7 -1.4 -0.8 -0.4 -2.7 -2.2 -3.3 -2.9 -2.5 -2.2 -0.9 -1.2 -2.0 -2.3 -2.9 -1.3 -3.2 -2.6 -0.9 -2.8 -2.0 -0.2 -2.8
Irritability 13.3 22.6 41.9 5.0 -6.4 -5.8 -6.1 -4.7 -3.6 -2.1 -4.3 -3.4 -0.4 -5.5 -6.0 -6.5 -6.1 -6.0 -5.1 -2.2 -1.9 -2.3 -5.8 -6.0 -1.4 -5.9 -4.6 -3.2 -6.1 -5.2 1.8 -4.6
Risk taking 1.7 2.5 8.6 -1.4 1.7 0.7 2.1 1.2 -0.1 2.8 0.6 -0.2 2.3 2.5 0.4 1.5 1.2 0.7 1.0 2.9 2.3 1.6 0.8 2.8 0.3 1.8 2.2 -0.3 1.3 0.1 0.6 1.3
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.3 1.0 0.3 -0.0 -0.2 -0.5 -0.1 -1.1 -0.6 -0.5 -0.9 0.2 -0.9 -1.0 -0.3 -0.4 0.1 -0.1 0.5 1.1 -0.9 -0.2 0.2 -0.5 0.7 0.5 -0.6 -0.2 0.5 -1.1
Fractured/broken bones in last 5 years 0.4 0.6 1.9 -0.5 0.9 0.7 0.8 -0.0 0.3 0.5 0.1 0.6 0.3 0.8 1.4 0.6 1.2 1.1 0.7 -0.1 0.1 0.1 1.1 0.1 -0.4 0.6 0.4 1.0 1.1 1.3 1.1 0.9
Age started oral contraceptive pill 0.7 0.9 4.2 1.1 -0.9 -1.0 -0.8 -0.7 -0.4 -0.9 -1.2 -0.4 -0.9 -1.4 -1.0 -0.9 -0.8 -0.9 -0.7 -1.5 -0.9 0.7 -1.0 -1.6 -0.4 -0.1 -0.4 0.1 -0.7 -0.4 1.1 -2.1
Diastolic blood pressure, automated reading 10.0 31.0 58.7 -4.3 6.8 7.0 6.8 4.3 1.3 2.5 6.0 5.5 -1.4 5.1 6.7 7.7 7.4 7.2 6.8 0.3 0.2 5.0 7.0 6.6 2.7 7.0 5.5 3.7 7.3 6.8 -3.0 5.9
Ever depressed for a whole week 1.0 1.2 3.0 1.3 -0.9 -1.2 -1.4 -1.4 -1.0 -1.7 -0.3 -0.3 -0.6 -1.3 -1.0 -1.6 -1.3 -1.0 -1.2 -1.5 -1.2 -0.3 -1.1 -1.5 0.7 -1.7 -0.2 0.2 -1.3 -0.5 -1.2 -0.6
Unable to work because of sickness or disability 0.9 1.1 7.1 -1.4 -0.4 -0.2 -1.0 0.1 -1.4 -1.6 1.1 -2.7 -1.5 0.1 -0.2 0.3 -0.4 -0.5 -0.1 -1.6 -0.9 -0.6 0.6 1.3 -1.2 0.5 0.6 -1.6 0.3 -0.7 -1.5 -0.6
Commuting to job workplace: Cycle 0.3 0.4 1.7 -1.2 0.5 0.7 0.5 1.3 0.4 -0.0 0.8 0.6 0.5 0.4 0.5 0.6 0.6 0.8 0.7 0.7 0.4 -0.2 0.6 -0.0 0.5 0.7 -0.2 0.4 0.4 0.3 0.3 1.0
Myopia 0.6 0.8 4.3 1.4 0.3 0.4 0.8 0.5 2.1 1.5 -0.8 1.1 0.5 0.6 -0.2 0.2 0.4 0.4 0.6 0.6 0.9 1.1 -0.1 0.7 2.1 0.8 0.6 1.5 0.1 0.1 0.8 0.8
Vascular/heart problems diagnosed by doctor 7.7 21.0 42.0 4.2 -5.8 -5.3 -5.8 -3.9 -1.9 -2.6 -4.1 -4.4 0.7 -4.9 -5.4 -6.4 -5.5 -5.6 -4.7 -0.5 -1.4 -4.3 -5.1 -4.7 -3.0 -6.5 -4.6 -4.4 -6.0 -5.4 1.8 -5.0
Cholesterol lowering medication 0.8 1.1 5.1 0.2 0.7 0.9 1.0 1.5 0.1 2.1 1.0 2.3 -0.0 0.9 1.0 0.9 1.1 1.1 0.9 0.7 0.1 1.1 0.7 0.5 0.9 0.7 0.3 1.5 1.1 1.7 -0.7 1.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 2.2 -1.0 -0.3 -0.2 -0.4 0.2 0.5 0.0 -0.4 -1.5 0.5 0.6 0.1 -0.3 -0.1 -0.1 -0.3 0.2 0.9 -1.0 -0.1 0.0 -0.2 -0.5 -0.4 -0.9 0.0 -0.7 0.3 0.4
Pain experienced in last month 0.5 0.9 5.2 -0.4 0.5 -0.4 0.6 0.8 2.1 0.7 -1.6 -0.1 1.2 0.9 -0.1 -0.9 -0.1 -0.3 -0.7 2.3 1.8 -0.5 -0.0 0.0 1.8 -0.3 0.2 0.1 -0.5 -0.8 0.5 -0.0
Supplements: Calcium 1.3 1.4 5.4 -1.3 1.1 0.8 0.9 1.3 1.6 -2.3 1.3 1.1 -1.0 0.9 1.2 1.2 0.7 1.1 1.3 -0.4 0.3 0.6 1.3 0.9 1.5 1.2 0.9 1.6 1.2 1.1 -0.7 1.3
Basal cell carcinoma (self-reported) 0.4 0.4 2.8 -0.9 -0.7 -0.5 -0.5 -0.3 0.4 0.1 -0.4 -0.0 0.9 -0.0 0.0 0.3 -0.3 -0.2 -0.9 0.2 0.2 -1.4 -0.1 -0.5 -0.4 -0.5 -1.3 -1.7 -0.1 -0.4 0.3 1.2
Heart attack/myocardial infarction (self-reported) 0.4 0.5 2.7 0.1 -0.2 -0.1 -0.4 -0.2 -0.6 -0.2 -0.6 -1.0 1.6 0.4 0.0 -0.3 -0.5 -0.5 -0.7 0.7 1.3 -1.6 -0.1 0.1 -0.4 -0.4 -0.6 -0.8 -0.5 -0.9 0.6 -0.4
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 4.3 -1.9 1.3 1.1 1.4 1.2 0.4 0.3 1.1 0.4 0.7 1.5 1.3 2.1 1.3 1.2 0.8 0.4 0.2 0.3 1.4 0.7 -1.6 1.6 0.8 -0.4 1.6 1.2 -1.0 1.0
Heart disease (siblings) 0.6 0.7 4.9 0.7 -0.2 0.1 0.1 -0.5 1.1 -1.0 -0.7 0.1 -1.7 -1.0 -0.2 -0.1 0.1 0.1 0.2 -2.2 -1.7 1.3 -0.0 -0.1 -1.5 0.1 0.6 0.4 0.2 0.8 0.5 -0.7
Alcohol drinker status: Previous 0.4 0.5 1.6 0.2 -0.7 -0.8 -0.9 -1.2 -0.8 -0.4 -0.6 -0.0 -0.8 -0.9 -0.8 -0.5 -0.6 -0.6 -0.6 -0.9 -1.3 -0.2 -0.6 -0.8 -1.0 -0.8 0.0 -0.2 -0.6 -0.2 -0.9 0.1
Pack years of smoking 0.3 0.4 1.2 -0.6 0.7 0.4 0.6 0.3 -0.7 0.2 1.1 -0.5 -0.5 -0.0 0.5 1.1 0.4 0.5 1.0 -0.5 -0.5 1.0 0.4 0.3 -0.5 1.1 0.7 0.3 0.7 0.6 -0.1 0.2
Impedance of whole body 6.2 31.7 66.2 8.1 -7.4 -5.9 -7.1 -4.6 -1.2 -4.2 -5.5 -2.6 -0.7 -7.7 -6.9 -7.8 -6.9 -6.1 -6.1 -2.1 -2.9 -3.3 -6.6 -7.0 -2.4 -7.6 -6.2 -2.7 -7.9 -5.2 1.9 -5.2
Leg fat mass (left) 2.3 9.1 21.1 -2.9 3.6 3.7 3.9 2.7 1.1 3.0 3.7 2.1 0.9 3.1 3.9 4.6 4.1 3.8 3.2 0.9 0.4 2.4 3.5 3.4 -0.4 3.8 2.3 1.3 4.2 3.6 -0.6 2.7
Arm predicted mass (left) 2.4 12.3 24.0 -4.5 4.7 3.7 4.5 2.9 1.4 3.2 2.9 2.1 1.1 4.6 4.6 4.9 4.6 4.1 3.6 1.9 2.1 1.9 4.1 4.0 1.1 4.8 3.5 1.6 4.8 3.4 0.1 3.2