Best TWAS P=5.24e-12 · Best GWAS P=7.55e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | REEP3 | 0.05 | 0.05 | lasso | 3 | 0.04 | 5.9e-06 | -6.7 | -6.8 | 1.4e-11 | 0.98 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Brain Cortex | NRBF2 | 0.30 | 0.26 | enet | 24 | 0.21 | 1.4e-06 | 6.2 | 6.2 | 5.4e-10 | -0.97 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | NRBF2 | 0.25 | 0.17 | lasso | 6 | 0.16 | 6.1e-05 | -6.5 | 6.6 | 3.8e-11 | -0.97 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Esophagus Mucosa | NRBF2 | 0.14 | 0.11 | lasso | 10 | 0.11 | 6.4e-08 | -6.8 | 6.9 | 5.2e-12 | -0.97 | 0.01 | 0.99 | TRUE |
| 5 | GTEx | Nerve Tibial | NRBF2 | 0.08 | 0.09 | enet | 11 | 0.06 | 5.0e-05 | -6.8 | 6.5 | 6.0e-11 | -0.94 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Testis | NRBF2 | 0.14 | 0.08 | lasso | 12 | 0.09 | 6.7e-05 | -6.8 | 6.4 | 2.0e-10 | -0.98 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Thyroid | NRBF2 | 0.11 | 0.05 | lasso | 3 | 0.07 | 2.5e-06 | 3.8 | 6.4 | 1.6e-10 | -0.73 | 0.03 | 0.96 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | NRBF2 | 0.34 | 0.46 | lasso | 5 | 0.46 | 3.1e-66 | -6.5 | 6.5 | 9.8e-11 | -0.98 | 0.02 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NRBF2 | 0.07 | 0.04 | blup | 42 | 0.02 | 7.3e-03 | -6.2 | 5.8 | 6.1e-09 | -0.83 | 0.00 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NRBF2 | 0.05 | 0.06 | lasso | 2 | 0.06 | 5.5e-12 | -6.5 | 6.5 | 1.0e-10 | -0.97 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | NRBF2 | 0.13 | 0.10 | enet | 11 | 0.09 | 4.9e-06 | -6.5 | 5.9 | 3.1e-09 | -0.82 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Glioblastoma Multiforme | JMJD1C | 0.11 | 0.02 | blup | 87 | 0.05 | 1.4e-02 | -6.2 | 6.7 | 2.3e-11 | -0.87 | 0.01 | 0.72 | FALSE |
| 13 | The Cancer Genome Atlas | Glioblastoma Multiforme | NRBF2 | 0.17 | 0.09 | enet | 10 | 0.13 | 1.1e-04 | -6.5 | 6.2 | 6.1e-10 | -0.87 | 0.00 | 0.96 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NRBF2 | 0.04 | 0.04 | enet | 5 | 0.03 | 1.3e-04 | -6.2 | 6.0 | 1.5e-09 | -0.95 | 0.00 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NRBF2 | 0.10 | 0.06 | lasso | 7 | 0.08 | 3.5e-09 | 3.5 | 5.3 | 1.5e-07 | -0.87 | 0.01 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NRBF2 | 0.08 | 0.08 | enet | 6 | 0.08 | 4.3e-09 | -6.5 | 6.3 | 3.4e-10 | -0.96 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | NRBF2 | 0.09 | 0.06 | enet | 8 | 0.07 | 2.7e-08 | -6.2 | 6.2 | 4.6e-10 | -0.92 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NRBF2 | 0.18 | 0.13 | enet | 11 | 0.08 | 2.5e-04 | -6.2 | 6.4 | 1.4e-10 | -0.88 | 0.00 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NRBF2 | 0.08 | 0.02 | blup | 40 | 0.04 | 8.6e-03 | -6.5 | 5.5 | 3.1e-08 | -0.87 | 0.00 | 0.90 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | JMJD1C | 0.04 | 0.01 | blup | 88 | 0.01 | 9.7e-03 | -6.7 | 6.2 | 4.6e-10 | -0.87 | 0.01 | 0.91 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NRBF2 | 0.08 | 0.09 | lasso | 6 | 0.08 | 9.7e-09 | -6.2 | 6.1 | 9.9e-10 | -0.97 | 0.00 | 1.00 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | NRBF2 | 0.14 | 0.10 | enet | 16 | 0.09 | 8.1e-09 | -6.2 | 5.9 | 4.4e-09 | -0.91 | 0.00 | 1.00 | FALSE |