[Hub]/) : Traits : Triglycerides :

chr11:60,549,966-62,346,131

Best TWAS P=8.6e-25 · Best GWAS P=5.41e-24 conditioned to 0.214

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FADS1 0.14 0.16 lasso 2 0.16 7.2e-19 10.04 -10.0 1.0e-23 -1.00 0.01 0.99 FALSE
2 CommonMind Brain Pre-frontal Cortex FEN1 0.07 0.06 lasso 4 0.06 1.1e-07 10.03 10.0 1.2e-23 1.00 0.01 0.99 FALSE
3 GTEx Artery Aorta FADS2 0.18 0.17 lasso 3 0.14 3.2e-08 5.03 6.6 4.4e-11 0.69 0.16 0.84 FALSE
4 GTEx Artery Tibial FADS2 0.08 0.02 lasso 4 0.02 6.9e-03 9.05 6.3 3.2e-10 0.81 0.02 0.97 FALSE
5 GTEx Artery Tibial TMEM258 0.08 0.05 lasso 5 0.02 1.1e-02 9.93 9.9 4.9e-23 0.98 0.02 0.98 FALSE
6 GTEx Artery Tibial FADS1 0.09 0.00 enet 29 0.01 7.0e-02 -3.64 -5.4 6.1e-08 -0.44 0.08 0.26 FALSE
7 GTEx Brain Cerebellum FADS1 0.35 0.24 enet 16 0.30 2.1e-09 9.87 -9.5 2.5e-21 -0.93 0.02 0.98 FALSE
8 GTEx Brain Cerebellum FADS3 0.26 0.18 lasso 4 0.14 5.7e-05 9.92 -10.3 8.6e-25 -0.94 0.02 0.89 TRUE
9 GTEx Brain Putamen basal ganglia FADS1 0.29 0.21 enet 30 0.16 1.4e-04 10.03 -6.4 1.8e-10 -0.79 0.01 0.94 FALSE
10 GTEx Breast Mammary Tissue (Female) TMEM258 0.20 0.02 lasso 7 0.00 2.3e-01 6.32 7.4 1.8e-13 0.78 0.04 0.53 FALSE
11 GTEx Cells Transformed fibroblasts FADS2 0.20 0.23 lasso 3 0.23 4.6e-17 5.03 5.2 2.2e-07 0.61 1.00 0.00 FALSE
12 GTEx Cells Transformed fibroblasts TMEM258 0.15 0.05 enet 15 0.07 1.1e-05 9.05 8.0 1.9e-15 0.79 0.03 0.97 FALSE
13 GTEx Colon Sigmoid FADS2 0.24 0.12 lasso 5 0.13 2.2e-05 3.92 5.7 1.5e-08 0.53 0.10 0.74 FALSE
14 GTEx Colon Transverse FADS2 0.18 0.11 lasso 7 0.16 8.1e-08 5.03 7.9 2.4e-15 0.77 0.04 0.96 FALSE
15 GTEx Esophagus Mucosa FADS1 0.11 0.00 lasso 4 0.02 1.9e-02 9.63 -8.5 2.2e-17 -0.88 0.02 0.93 FALSE
16 GTEx Esophagus Muscularis FADS2 0.32 0.30 lasso 6 0.31 3.7e-19 5.03 6.4 1.9e-10 0.72 0.95 0.05 FALSE
17 GTEx Heart Left Ventricle FADS2 0.17 0.12 enet 3 0.13 1.5e-07 5.30 6.1 1.3e-09 0.72 0.26 0.74 FALSE
18 GTEx Muscle Skeletal FADS2 0.08 0.04 lasso 2 0.03 5.9e-04 9.69 8.6 7.3e-18 0.91 0.04 0.96 FALSE
19 GTEx Pancreas FADS1 0.17 0.13 lasso 6 0.12 1.2e-05 9.92 -10.0 9.5e-24 -0.94 0.02 0.98 FALSE
20 GTEx Spleen FADS2 0.30 0.27 lasso 3 0.27 1.6e-07 5.03 6.5 9.1e-11 0.73 0.08 0.90 FALSE
21 GTEx Uterus PPP1R32 0.66 -0.01 lasso 13 0.14 8.8e-04 0.18 5.1 2.7e-07 0.59 0.03 0.46 FALSE
22 GTEx Whole Blood FADS2 0.49 0.48 lasso 5 0.48 3.0e-49 5.03 5.2 1.8e-07 0.61 1.00 0.00 FALSE
23 METSIM Adipose TMEM258 0.04 0.00 bslmm 407 0.01 4.1e-02 9.92 8.2 1.9e-16 0.65 0.02 0.90 FALSE
24 NTR Blood C11orf10 0.06 0.08 bslmm 399 0.08 1.3e-24 9.05 9.4 4.2e-21 0.94 0.04 0.96 FALSE
25 NTR Blood FADS2 0.30 0.33 lasso 7 0.33 9.0e-109 5.03 5.6 1.7e-08 0.64 1.00 0.00 FALSE
26 ROSMAP Brain Pre-frontal Cortex TMEM258 0.14 0.16 lasso 4 0.15 4.7e-19 9.05 9.3 8.5e-21 0.96 0.04 0.96 FALSE
27 ROSMAP Brain Pre-frontal Cortex FADS1 0.08 0.08 enet 10 0.09 1.5e-11 10.00 -10.2 2.3e-24 -0.98 0.01 0.99 FALSE
28 YFS Blood FADS1 0.11 0.08 lasso 8 0.09 6.1e-29 5.03 7.4 1.7e-13 0.78 1.00 0.00 FALSE
29 The Cancer Genome Atlas Breast Invasive Carcinoma FADS1 0.04 0.00 blup 53 0.01 1.4e-03 3.77 -6.0 2.2e-09 -0.60 0.02 0.41 FALSE
30 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma FADS1 0.06 0.03 lasso 4 0.04 7.4e-03 9.92 -9.5 1.7e-21 -0.84 0.01 0.77 FALSE
31 The Cancer Genome Atlas Colon Adenocarcinoma FADS2 0.30 0.21 lasso 2 0.22 6.7e-13 5.03 6.9 4.3e-12 0.77 0.65 0.35 FALSE
32 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FADS2 0.05 0.04 lasso 3 0.05 1.9e-06 5.03 6.7 1.6e-11 0.71 0.19 0.77 FALSE
33 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FADS2 0.26 0.29 enet 15 0.29 2.9e-33 5.03 6.8 8.7e-12 0.74 1.00 0.00 FALSE
34 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FADS2 0.33 0.27 lasso 9 0.35 9.3e-21 5.03 7.1 1.2e-12 0.80 0.42 0.58 FALSE
35 The Cancer Genome Atlas Brain Lower Grade Glioma FADS1 0.05 0.05 blup 53 0.04 6.8e-05 7.99 -7.9 3.8e-15 -0.87 0.04 0.96 FALSE
36 The Cancer Genome Atlas Liver Hepatocellular Carcinoma FADS1 0.20 0.01 blup 51 0.07 3.2e-04 9.93 -8.1 7.2e-16 -0.86 0.02 0.92 FALSE
37 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FADS2 0.02 0.01 blup 71 0.02 1.9e-03 9.69 9.2 4.7e-20 0.91 0.02 0.79 FALSE
38 The Cancer Genome Atlas Prostate Adenocarcinoma FADS1 0.06 0.04 blup 53 0.03 2.0e-04 9.87 -8.4 4.3e-17 -0.73 0.02 0.82 FALSE
39 The Cancer Genome Atlas Prostate Adenocarcinoma FADS2 0.07 0.07 lasso 4 0.06 1.9e-06 5.03 5.7 1.1e-08 0.70 0.17 0.81 FALSE
40 The Cancer Genome Atlas Rectum Adenocarcinoma FADS2 0.47 0.34 lasso 5 0.30 7.9e-08 5.03 6.3 2.4e-10 0.69 0.04 0.94 FALSE
41 The Cancer Genome Atlas Stomach Adenocarcinoma FADS2 0.15 0.05 blup 71 0.11 2.5e-08 5.03 7.6 3.1e-14 0.72 0.04 0.96 FALSE
42 The Cancer Genome Atlas Thyroid Carcinoma C11orf10 0.02 0.02 blup 44 0.02 1.8e-03 8.25 9.4 4.0e-21 0.97 0.02 0.73 FALSE
43 The Cancer Genome Atlas Thyroid Carcinoma FADS2 0.30 0.33 lasso 8 0.33 5.6e-33 5.03 6.5 6.6e-11 0.72 1.00 0.00 FALSE