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chr11:60,549,966-62,346,131

Best TWAS P=8.6e-25 · Best GWAS P=5.41e-24 conditioned to 0.214

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	10.04	-10.0	1.0e-23	-1.00	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	10.03	10.0	1.2e-23	1.00	0.01	0.99	FALSE
3	GTEx	Artery Aorta	FADS2	0.18	0.17	lasso	3	0.14	3.2e-08	5.03	6.6	4.4e-11	0.69	0.16	0.84	FALSE
4	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	9.05	6.3	3.2e-10	0.81	0.02	0.97	FALSE
5	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	9.93	9.9	4.9e-23	0.98	0.02	0.98	FALSE
6	GTEx	Artery Tibial	FADS1	0.09	0.00	enet	29	0.01	7.0e-02	-3.64	-5.4	6.1e-08	-0.44	0.08	0.26	FALSE
7	GTEx	Brain Cerebellum	FADS1	0.35	0.24	enet	16	0.30	2.1e-09	9.87	-9.5	2.5e-21	-0.93	0.02	0.98	FALSE
8	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	9.92	-10.3	8.6e-25	-0.94	0.02	0.89	TRUE
9	GTEx	Brain Putamen basal ganglia	FADS1	0.29	0.21	enet	30	0.16	1.4e-04	10.03	-6.4	1.8e-10	-0.79	0.01	0.94	FALSE
10	GTEx	Breast Mammary Tissue (Female)	TMEM258	0.20	0.02	lasso	7	0.00	2.3e-01	6.32	7.4	1.8e-13	0.78	0.04	0.53	FALSE
11	GTEx	Cells Transformed fibroblasts	FADS2	0.20	0.23	lasso	3	0.23	4.6e-17	5.03	5.2	2.2e-07	0.61	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	TMEM258	0.15	0.05	enet	15	0.07	1.1e-05	9.05	8.0	1.9e-15	0.79	0.03	0.97	FALSE
13	GTEx	Colon Sigmoid	FADS2	0.24	0.12	lasso	5	0.13	2.2e-05	3.92	5.7	1.5e-08	0.53	0.10	0.74	FALSE
14	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	5.03	7.9	2.4e-15	0.77	0.04	0.96	FALSE
15	GTEx	Esophagus Mucosa	FADS1	0.11	0.00	lasso	4	0.02	1.9e-02	9.63	-8.5	2.2e-17	-0.88	0.02	0.93	FALSE
16	GTEx	Esophagus Muscularis	FADS2	0.32	0.30	lasso	6	0.31	3.7e-19	5.03	6.4	1.9e-10	0.72	0.95	0.05	FALSE
17	GTEx	Heart Left Ventricle	FADS2	0.17	0.12	enet	3	0.13	1.5e-07	5.30	6.1	1.3e-09	0.72	0.26	0.74	FALSE
18	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	9.69	8.6	7.3e-18	0.91	0.04	0.96	FALSE
19	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	9.92	-10.0	9.5e-24	-0.94	0.02	0.98	FALSE
20	GTEx	Spleen	FADS2	0.30	0.27	lasso	3	0.27	1.6e-07	5.03	6.5	9.1e-11	0.73	0.08	0.90	FALSE
21	GTEx	Uterus	PPP1R32	0.66	-0.01	lasso	13	0.14	8.8e-04	0.18	5.1	2.7e-07	0.59	0.03	0.46	FALSE
22	GTEx	Whole Blood	FADS2	0.49	0.48	lasso	5	0.48	3.0e-49	5.03	5.2	1.8e-07	0.61	1.00	0.00	FALSE
23	METSIM	Adipose	TMEM258	0.04	0.00	bslmm	407	0.01	4.1e-02	9.92	8.2	1.9e-16	0.65	0.02	0.90	FALSE
24	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	9.05	9.4	4.2e-21	0.94	0.04	0.96	FALSE
25	NTR	Blood	FADS2	0.30	0.33	lasso	7	0.33	9.0e-109	5.03	5.6	1.7e-08	0.64	1.00	0.00	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	9.05	9.3	8.5e-21	0.96	0.04	0.96	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	10.00	-10.2	2.3e-24	-0.98	0.01	0.99	FALSE
28	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	5.03	7.4	1.7e-13	0.78	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS1	0.04	0.00	blup	53	0.01	1.4e-03	3.77	-6.0	2.2e-09	-0.60	0.02	0.41	FALSE
30	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FADS1	0.06	0.03	lasso	4	0.04	7.4e-03	9.92	-9.5	1.7e-21	-0.84	0.01	0.77	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	FADS2	0.30	0.21	lasso	2	0.22	6.7e-13	5.03	6.9	4.3e-12	0.77	0.65	0.35	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FADS2	0.05	0.04	lasso	3	0.05	1.9e-06	5.03	6.7	1.6e-11	0.71	0.19	0.77	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FADS2	0.26	0.29	enet	15	0.29	2.9e-33	5.03	6.8	8.7e-12	0.74	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FADS2	0.33	0.27	lasso	9	0.35	9.3e-21	5.03	7.1	1.2e-12	0.80	0.42	0.58	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	7.99	-7.9	3.8e-15	-0.87	0.04	0.96	FALSE
36	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FADS1	0.20	0.01	blup	51	0.07	3.2e-04	9.93	-8.1	7.2e-16	-0.86	0.02	0.92	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FADS2	0.02	0.01	blup	71	0.02	1.9e-03	9.69	9.2	4.7e-20	0.91	0.02	0.79	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS1	0.06	0.04	blup	53	0.03	2.0e-04	9.87	-8.4	4.3e-17	-0.73	0.02	0.82	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS2	0.07	0.07	lasso	4	0.06	1.9e-06	5.03	5.7	1.1e-08	0.70	0.17	0.81	FALSE
40	The Cancer Genome Atlas	Rectum Adenocarcinoma	FADS2	0.47	0.34	lasso	5	0.30	7.9e-08	5.03	6.3	2.4e-10	0.69	0.04	0.94	FALSE
41	The Cancer Genome Atlas	Stomach Adenocarcinoma	FADS2	0.15	0.05	blup	71	0.11	2.5e-08	5.03	7.6	3.1e-14	0.72	0.04	0.96	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	8.25	9.4	4.0e-21	0.97	0.02	0.73	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	FADS2	0.30	0.33	lasso	8	0.33	5.6e-33	5.03	6.5	6.6e-11	0.72	1.00	0.00	FALSE