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chr1:1,781,220-3,261,925

Best TWAS P=1.91e-11 · Best GWAS P=2.08e-11 conditioned to 0.671

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC115110	0.01	0.01	enet	14	0.01	5.2e-04	-6.7	6.7	1.9e-11	-0.71	0.01	0.96	TRUE
5	GTEx	Uterus	RP3-395M20.9	0.25	0.08	lasso	3	0.07	1.3e-02	-5.5	-6.0	2.1e-09	0.61	0.05	0.46	TRUE
3	GTEx	Esophagus Muscularis	RP3-395M20.12	0.08	0.06	enet	6	0.06	2.3e-04	-6.0	6.4	1.2e-10	-0.83	0.02	0.96	FALSE
12	The Cancer Genome Atlas	Lung Adenocarcinoma	MMEL1	0.05	0.03	blup	39	0.05	1.6e-06	-6.5	6.2	6.3e-10	-0.84	0.02	0.98	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	MMEL1	0.02	0.02	blup	38	0.03	3.3e-06	-5.0	6.0	2.6e-09	-0.84	0.18	0.81	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	RP3-395M20.9	0.06	0.01	blup	367	0.04	5.7e-06	-4.9	-5.9	3.7e-09	0.73	0.11	0.88	FALSE
6	GTEx	Whole Blood	FAM213B	0.06	0.00	lasso	3	0.00	6.5e-01	5.5	5.9	4.3e-09	-0.78	0.04	0.64	FALSE
14	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC115110	0.03	0.00	blup	50	0.01	1.7e-02	-6.6	5.9	4.4e-09	-0.85	0.01	0.58	FALSE
1	GTEx	Brain Cerebellum	TNFRSF14	0.17	0.07	enet	6	0.10	7.6e-04	-6.0	-5.8	5.6e-09	0.89	0.02	0.90	FALSE
4	GTEx	Pancreas	TNFRSF14	0.13	0.04	enet	8	0.04	1.0e-02	-6.0	-5.8	5.9e-09	0.87	0.05	0.92	FALSE
15	The Cancer Genome Atlas	Prostate Adenocarcinoma	MMEL1	0.10	0.12	enet	22	0.15	8.5e-16	-5.3	5.7	1.2e-08	-0.78	0.25	0.75	FALSE
9	YFS	Blood	MMEL1	0.04	0.05	lasso	4	0.05	4.6e-17	-5.3	5.6	2.1e-08	-0.73	0.92	0.08	FALSE
17	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TNFRSF14	0.18	0.02	blup	52	0.10	2.4e-04	-2.4	-5.5	3.0e-08	0.71	0.01	0.51	FALSE
2	GTEx	Brain Cerebellum	RP3-395M20.8	0.19	0.05	enet	8	0.06	5.9e-03	-3.5	-5.5	3.4e-08	0.83	0.03	0.84	FALSE
13	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MMEL1	0.03	0.01	enet	8	0.02	1.8e-03	-5.1	5.3	1.1e-07	-0.59	0.08	0.21	FALSE
7	METSIM	Adipose	MMEL1	0.07	0.08	lasso	4	0.08	5.5e-12	-5.1	5.1	2.8e-07	-0.67	0.94	0.06	FALSE
16	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MMEL1	0.13	0.14	lasso	6	0.13	2.2e-05	-5.1	5.1	2.9e-07	-0.67	0.36	0.20	FALSE