Hub : Genes

FAM213B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.0820 0.039 0.0075 0.017 NA -0.003 NA 0.014 0.024 NA 0.680 NA 0.039
2 GTEx Lung 0.0533 0.024 0.0048 0.001 NA 0.008 NA 0.003 0.280 NA 0.068 NA 0.170
3 GTEx Thyroid 0.0980 0.039 0.0016 -0.002 NA -0.003 NA -0.004 0.450 NA 0.790 NA 0.980
4 GTEx Whole Blood 0.0560 0.027 0.0073 0.000 NA -0.003 NA -0.002 0.330 NA 0.730 NA 0.650

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.9 2.7 -0.1 -1.6 -0.4 -0.8
Bipolar Disorder or Schizophrenia 1.2 2.9 4.5 0.9 -2.1 -1.7 -1.8
Depressed Affect (Nagel 2018) 1.6 3.3 4.7 -1.9 1.1 -2.2 1.9
Depression (Nagel 2018) 1.0 1.5 2.7 -1.7 0.4 -0.9 1.5
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.5 -0.4 0.5 -0.7 -0.2
Neuroticism (Nagel 2018) 1.4 3.3 6.1 -1.6 0.1 -2.1 2.5
Schizophrenia (2018) 1.3 2.7 3.5 1.3 -1.6 -1.9 -1.7
Schizophrenia vs Biploar Disorder 0.4 0.5 1.1 1.0 -0.4 0.8 -0.2
Worry (Nagel 2018) 1.5 3.2 6.8 -1.5 -0.5 -1.9 2.6
Alzheimer’s Disease (in mother) 1.8 2.1 2.8 1.7 -1.6 -0.5 -1.7
Alzheimer’s Disease (in father) 0.3 0.3 0.5 0.7 0.1 0.5 -0.7
Alzheimer’s Disease (including proxy) 1.6 2.3 3.0 1.7 -1.7 -1.2 -1.3
Crohns Disease (2017) 0.2 0.5 1.4 1.2 -0.4 0.6 0.1
Irritable Bowel Disease (IBD) 4.1 9.7 18.8 -2.0 2.5 3.1 4.3
Ulcerative Colitis (UC) 10.3 19.3 34.5 -3.9 3.7 3.7 5.9
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.4 0.8 2.6 -1.6 -0.1 0.6 0.2
Verbal and Numeric Reasoning (VNR) 0.3 0.8 2.3 -0.1 0.9 -1.5 -0.1
Breast Cancer 0.6 1.5 3.0 0.0 -1.7 -1.3 -1.1
Ovarian Cancer 0.1 0.1 0.2 0.3 -0.1 0.4 0.4
Prostate Cancer 0.2 0.3 0.9 -0.1 -0.4 -0.9 -0.4
Age at First Birth 0.4 0.5 0.9 -0.9 -0.8 0.4 0.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 6.3 8.6 16.5 2.4 -1.9 -2.9 -4.1
Coronary Artery Disease (CAD) 0.1 0.2 0.5 0.2 0.7 -0.1 0.2
Crohns Disease (2012) 0.4 0.6 1.1 0.3 0.6 0.9 1.1
Mean Putamen Volume 1.1 1.3 2.9 -0.5 -1.7 -0.5 -1.3
Fasting Glucose 0.8 1.0 3.7 0.4 1.9 -0.1 -0.4
HbA1C 0.4 0.5 1.1 0.1 0.9 -0.1 1.0
HDL Cholesterol 0.5 0.8 1.4 0.7 -0.2 1.2 1.1
LDL Cholesterol 0.0 0.1 0.2 0.2 -0.0 0.1 -0.4
Lupus 2.5 3.7 6.0 -1.6 2.2 2.5 1.1
Neuroticism (2016) 0.4 0.6 1.2 -0.6 0.9 -1.1 0.1
Primary Biliary Cirrhosis 5.2 7.4 14.4 2.0 -3.8 -2.6 -2.0
Rheumatoid Arthritis 2.5 3.5 6.0 -2.1 2.5 1.1 1.5
Schizophrenia (2014) 0.3 0.8 2.3 0.1 -1.5 -0.8 -0.4
Triglycerides 0.5 0.8 1.8 -0.1 -0.8 -0.8 -1.3
Type 2 Diabetes (T2D) (2012) 2.4 2.7 4.8 -1.1 2.2 1.7 1.4
Ulcerative Colitis 12.1 17.5 32.3 -4.5 3.5 2.3 5.7
Blood Eosinophil Count 2.6 20.2 37.3 -6.1 0.9 2.6 6.0
Blood Platelet Count 0.8 9.8 20.7 -1.3 4.5 3.3 2.4
Blood Red Count 0.3 3.3 6.7 -0.6 2.6 2.5 -0.1
Blood White Count 0.1 0.8 1.7 0.4 0.8 1.3 -0.7
Heel T-Score 0.4 3.0 6.0 -1.0 -0.6 2.4 2.2
BMI 2.7 15.7 34.9 3.5 -3.8 -1.2 -5.9
Height 0.7 13.2 39.4 0.3 -3.0 -6.3 -2.0
Waist Hip Ratio (WHR) 0.7 3.0 6.4 2.4 2.5 0.3 0.3
Systolic Blood Pressure 0.8 3.8 12.7 -1.2 1.1 3.6 -0.2
Smoking Status 0.2 0.4 0.8 0.9 -0.3 0.7 0.5
Allergy or Eczema 2.6 6.8 16.7 -2.4 0.4 2.1 4.1
Cardiovascular Disease 0.8 2.5 5.7 0.5 -2.4 0.8 -1.8
Hypothyroidism (self reported) 1.7 3.8 5.3 -1.1 2.3 2.1 2.1
Respiratory disease 3.4 7.5 13.4 -1.9 2.0 3.0 3.7
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.0 1.0 -0.2 1.0 0.0
Lung FEV1/FVC ratio 2.6 12.9 21.5 2.8 -4.3 -2.1 -4.6
Lung FVC 0.5 2.5 7.6 -0.0 2.8 0.8 1.4
Neuroticism 1.0 2.5 3.8 -1.4 0.6 -1.9 2.0
Chronotype (morning person) 1.2 2.9 5.8 1.0 -1.7 -1.3 -2.4
Hair Pigment 0.1 3.2 5.0 2.2 0.2 -2.0 -1.9
Tanning 0.1 1.7 2.6 -0.4 -1.6 1.3 1.6
Hand grip strength (left) 0.9 2.2 3.9 0.9 -2.0 -1.2 -1.7
Number of treatments/medications taken 1.6 2.9 4.5 -2.1 1.8 1.8 0.9
Average weekly spirits intake 1.2 1.5 4.8 0.9 0.4 2.2 -0.2
Sensitivity / hurt feelings 0.7 1.2 2.0 -0.7 -1.3 -1.4 0.8
Frequency of depressed mood in last 2 weeks 1.1 1.5 3.3 -1.1 0.5 -1.8 1.1
Hearing difficulty/problems: Yes 0.9 1.3 3.3 0.2 1.8 0.3 1.4
Relative age of first facial hair 0.4 0.9 1.9 1.4 -0.5 -0.2 1.2
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.3 -0.7 1.1 0.5 0.7
Ever used hormone-replacement therapy (HRT) 1.7 2.2 3.2 -0.3 1.8 1.7 1.6
Ever had hysterectomy (womb removed) 1.6 1.8 3.3 -0.5 1.8 0.7 1.8
Systolic blood pressure, automated reading 0.6 1.8 6.2 0.5 0.7 2.5 -0.6
Eye problems/disorders: Diabetes related eye disease 3.3 3.6 6.0 -2.1 2.4 1.3 1.6
Angina 1.0 1.4 4.8 2.2 -0.6 -0.5 0.0
Medication for hormone replacement therapy 2.9 3.3 4.8 -2.0 1.1 2.2 1.7
Vitamin and mineral supplements 0.5 0.6 1.8 0.3 -0.5 0.6 -1.3
Supplements: Zinc 0.1 0.1 0.2 -0.1 -0.4 -0.4 0.5
Medication: Co-codamol 0.4 0.4 1.0 0.1 -0.3 -0.8 -1.0
Medication: Metformin 0.0 0.0 0.1 0.0 0.2 0.2 -0.0
Diabetes (father) 0.6 0.8 1.5 0.7 -0.9 -1.2 -0.6
Diabetes (mother) 1.1 1.5 3.0 1.7 -0.4 1.6 -0.4
Severe depression (siblings) 3.3 3.7 6.1 1.3 -2.1 -1.5 -2.5
Pack years adult smoking proportion 0.7 1.0 1.6 1.3 -1.2 0.6 -0.8
Impedance of leg (right) 0.9 4.3 9.4 -2.6 -0.3 0.7 3.1
Leg fat-free mass (left) 1.6 8.2 13.2 2.8 -2.5 -2.3 -3.6
Trunk fat percentage 2.3 9.4 13.3 2.5 -3.6 -2.3 -3.6
Hand grip strength (right) 0.8 2.2 3.7 1.1 -1.9 -1.6 -1.2
Townsend deprivation index at recruitment 0.6 0.8 1.4 0.2 -1.2 -0.5 -1.2
Current tobacco smoking 0.2 0.3 0.6 0.6 -0.8 0.0 0.0
Average weekly fortified wine intake 0.4 0.5 1.8 0.5 -1.4 -0.1 0.0
Maternal smoking around birth 1.8 2.6 5.6 0.7 0.6 2.4 1.9
Fed-up feelings 0.8 1.5 2.3 -1.5 0.4 -1.5 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.4 -0.7 0.1 -1.2 0.7
Relative age voice broke 0.6 0.9 1.7 1.2 -1.3 -0.8 0.2
Taking other prescription medications 1.4 2.1 4.3 -1.5 2.1 0.4 1.3
Age when periods started (menarche) 0.7 1.6 6.3 0.3 -0.0 -2.5 0.0
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 2.0 -0.8 1.4 0.4 1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.1 0.4 -0.1 -0.2 0.7 -0.3
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.8 0.2 0.0 -0.5 -0.9
Qualifications: CSEs or equivalent 1.8 2.4 5.8 1.0 -1.5 -0.8 -2.4
Serious illness, injury or assault to yourself 0.7 0.8 1.7 0.6 1.0 1.3 0.4
High blood pressure 0.5 1.5 2.4 0.6 -1.4 1.1 -1.5
Hayfever, allergic rhinitis or eczema 2.9 6.3 17.1 -1.7 0.0 2.3 4.1
Multivitamins +/- minerals 1.3 1.7 4.3 2.1 -0.8 -1.3 -0.5
Stomach or abdominal pain in last month 1.3 1.6 5.0 -0.9 0.3 0.6 2.2
Supplements: Glucosamine 0.3 0.3 1.3 0.0 0.2 -1.1 -0.0
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.9 -0.2 -1.0 0.4 -0.7
Medication: Atenolol 0.7 0.8 2.0 -1.4 -0.7 -0.1 0.9
Medication: Levothyroxine sodium 3.7 6.2 8.8 -1.6 3.0 2.7 2.5
Sitting height 0.0 0.3 0.6 -0.2 0.4 -0.8 0.5
Chronic bronchitis/emphysema (father) 0.4 0.4 0.9 0.4 0.8 1.0 0.3
High blood pressure (mother) 0.7 1.0 3.0 0.8 -0.6 1.7 0.0
Body mass index (BMI) 2.3 10.0 18.9 3.6 -2.4 -1.4 -4.3
Impedance of leg (left) 0.7 3.3 6.7 -2.4 -0.3 0.8 2.6
Leg predicted mass (left) 1.5 8.0 13.2 2.8 -2.4 -2.2 -3.6
Trunk fat mass 2.7 11.5 17.5 2.8 -3.6 -2.7 -4.2
Waist circumference 2.4 8.8 14.8 3.9 -1.6 -2.0 -3.8
Number of incorrect matches in round 1.5 2.6 9.0 0.2 -1.0 -3.0 -0.4
Past tobacco smoking 0.2 0.5 1.1 -0.8 -0.2 -1.1 -0.3
Alcohol usually taken with meals 0.8 1.2 3.0 0.2 -1.7 -1.4 0.1
Nervous feelings 0.4 0.7 1.7 -0.2 -0.8 -1.3 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.2 2.0 -1.3 0.1 -1.0 1.4
Hearing difficulty/problems with background noise 0.4 0.7 1.8 1.4 0.7 0.5 -0.1
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 0.2 0.1 -0.3 -0.4
Had menopause 0.5 0.6 1.2 0.3 1.1 -0.4 0.9
Had other major operations 1.5 1.9 3.6 -1.1 1.1 1.2 1.9
Forced vital capacity (FVC) 0.1 0.2 0.6 -0.3 0.3 -0.7 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.6 -0.6 -0.2 0.8 0.4
Ever unenthusiastic/disinterested for a whole week 2.9 3.6 5.9 -1.5 2.1 1.3 2.4
Qualifications: None of the above 0.3 0.7 2.1 0.6 1.4 -0.1 -0.7
Financial difficulties in last 2 years 0.9 1.2 3.2 0.3 -0.9 -1.8 -0.7
Mouth/teeth dental problems 0.1 0.2 0.5 -0.5 -0.1 0.3 0.7
Heart attack 1.6 2.1 4.5 -0.3 -1.7 -1.0 -2.1
Allergy 3.6 8.3 21.2 2.2 -0.3 -2.7 -4.6
Pain all over the body in last month 1.6 1.8 3.5 1.9 -0.3 -1.9 0.1
Diabetes (self-reported) 1.5 2.3 6.4 -0.0 2.5 1.3 1.0
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.5 -0.4 -0.5 1.2 -1.0
Medication: Ramipril 0.5 0.6 1.5 -0.1 -1.2 0.6 -0.8
Medication: Simvastatin 0.1 0.2 0.5 -0.7 0.1 -0.4 0.1
Fluid intelligence score 1.3 2.6 4.4 -1.3 2.1 1.5 1.4
Illnesses of siblings 0.5 0.7 1.3 -0.9 0.4 -0.6 1.1
Neuroticism score 1.0 2.1 3.0 -1.5 0.9 -1.5 1.7
Weight 2.4 11.8 19.4 3.5 -2.9 -2.7 -4.4
Impedance of arm (right) 1.2 5.5 12.5 -3.5 -0.7 -0.3 3.0
Arm fat percentage (right) 1.7 6.5 12.2 2.4 -2.5 -1.3 -3.5
Trunk fat-free mass 0.9 5.1 8.1 2.4 -1.1 -2.3 -2.8
Hip circumference 1.7 7.4 11.8 2.3 -2.9 -2.0 -3.4
Time employed in main current job 0.4 0.4 1.6 -0.1 1.3 -0.2 -0.1
Alcohol intake versus 10 years previously 0.5 0.7 1.7 1.0 -0.3 -1.3 -0.1
Father’s age at death 0.7 1.0 2.7 -1.0 -0.5 -0.0 1.6
Worrier / anxious feelings 1.5 2.9 6.0 -2.4 0.1 -1.7 1.7
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 4.2 -2.1 0.5 0.1 0.4
Falls in the last year 1.4 1.8 3.6 1.6 1.9 1.1 -0.4
Hair/balding pattern: Pattern 3 0.2 0.2 0.5 -0.4 0.1 0.7 0.5
Number of live births 0.8 1.1 1.8 1.3 1.2 0.6 -0.8
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 1.7 1.0 -0.9 -1.3 -1.1
Pulse rate 0.5 0.8 1.7 -1.3 -0.9 -0.7 0.3
Happiness 0.5 0.6 1.7 -1.3 0.1 -0.6 0.6
Noisy workplace 1.4 1.7 3.9 2.0 1.1 1.1 -0.7
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.8 0.5 -0.9 0.2 -0.2
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 3.5 -1.9 0.3 -0.2 1.4
Mouth/teeth dental problems: Dentures 0.3 0.5 1.3 1.1 0.2 0.2 -0.9
Asthma 3.2 6.4 8.2 -2.7 1.9 2.6 2.9
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 4.6 -0.1 -0.1 2.1 0.6
Medication: Cholesterol lowering 0.4 0.7 2.1 -1.4 0.6 -0.4 0.3
Depression (self-reported) 0.4 0.5 0.7 -0.6 -0.9 -0.7 0.6
Medication: Lansoprazole 0.7 0.8 1.4 1.2 -0.7 -1.1 0.4
Prospective memory result 4.7 5.8 13.6 -0.4 -3.7 -2.5 -1.8
Lung cancer (father) 0.3 0.3 0.8 0.7 -0.2 -0.2 -0.9
Illnesses of mother 1.6 1.9 3.1 -1.8 1.6 -1.1 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.4 5.0 1.2 -1.5 -2.2 -1.0
Pulse wave Arterial Stiffness index 1.5 1.8 4.6 1.5 -0.3 -0.4 -2.1
Impedance of arm (left) 1.3 5.9 15.1 -3.9 -0.6 -0.8 2.7
Arm fat mass (right) 2.1 8.8 16.5 3.0 -2.6 -1.7 -4.1
Trunk predicted mass 0.9 4.9 7.5 2.4 -1.1 -2.3 -2.7
Standing height 0.3 3.1 9.7 -0.0 -1.6 -3.1 -0.5
Length of working week for main job 2.1 2.3 5.3 2.3 0.2 -0.3 -1.9
Exposure to tobacco smoke at home 0.5 0.6 2.4 -0.1 1.5 0.2 -0.0
Breastfed as a baby 3.1 3.8 5.5 1.8 -2.3 -2.2 -1.3
Tense / ‘highly strung’ 2.1 3.5 7.9 -2.4 -0.2 -0.5 2.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 2.3 -0.1 -1.4 -1.5 -0.9
Hair/balding pattern: Pattern 4 0.3 0.7 1.7 1.3 -0.4 0.2 -1.0
Birth weight of first child 0.4 0.7 1.0 -0.6 -1.0 0.7 0.9
Peak expiratory flow (PEF) 0.7 1.6 5.0 2.2 -0.1 -0.0 -1.2
Pulse wave reflection index 1.1 1.3 3.2 1.8 0.6 0.1 -1.3
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.6 -0.5 0.8 -0.1 0.1
Loud music exposure frequency 1.6 1.7 3.0 -0.4 1.7 1.6 1.1
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 1.8 1.1 -1.3 -0.4 -1.1
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 2.8 1.7 -0.4 -1.3 -1.1
Blood clot in the leg (DVT) 0.3 0.4 1.0 0.3 -0.4 0.4 1.0
Medication: Paracetamol 0.2 0.3 0.5 -0.4 -0.7 -0.6 -0.0
Headache pain in last month 0.5 0.9 2.3 -0.7 0.5 1.5 0.6
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 1.6 1.3 -0.6 -0.2 0.5
Glaucoma (self-reported) 0.6 0.7 1.7 0.7 -1.3 -0.7 0.0
Gout (self-reported) 0.4 0.5 1.4 1.2 -0.4 0.1 -0.8
Hypothyroidism/myxoedema (self-reported) 2.9 5.6 8.6 -1.7 2.9 2.3 2.4
Medication: Amlodipine 0.2 0.3 0.7 0.5 0.8 0.3 -0.4
Medication: Ventolin 100micrograms inhaler 3.4 4.4 5.4 -2.3 2.1 1.7 2.2
Birth weight 0.5 1.2 3.4 0.9 -0.7 -1.8 -0.2
Chronic bronchitis/emphysema (mother) 1.5 1.7 4.1 1.3 -0.9 2.0 0.4
High blood pressure (siblings) 0.2 0.2 0.5 -0.1 -0.2 -0.6 -0.7
Forced vital capacity (FVC), Best measure 0.2 0.9 2.8 -0.5 0.1 -1.7 0.7
Body fat percentage 2.3 9.0 14.1 2.8 -3.3 -1.8 -3.8
Leg fat percentage (right) 2.3 8.3 11.2 3.0 -3.4 -1.4 -3.3
Arm fat-free mass (right) 1.8 9.1 13.8 3.5 -2.1 -2.5 -3.7
Exposure to tobacco smoke outside home 1.7 2.3 5.8 1.7 -0.7 -0.3 -2.4
Comparative body size at age 10 2.7 7.4 11.1 3.0 -1.8 -2.5 -3.3
Number of full brothers 1.1 1.4 5.0 2.2 0.1 -0.3 -0.6
Worry too long after embarrassment 0.7 1.2 2.1 1.4 -1.0 -1.2 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 2.2 0.1 -0.4 -1.5 0.2
Wheeze or whistling in the chest in last year 0.4 0.8 2.6 0.2 -0.0 1.6 0.6
Number of children fathered 0.9 1.0 1.9 1.4 0.9 0.3 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 3.3 -0.2 -1.8 0.3 0.4
Age at first live birth 0.1 0.1 0.2 -0.3 -0.3 -0.5 0.0
Pulse wave peak to peak time 1.5 1.7 4.8 -1.3 0.5 0.6 2.2
Health satisfaction 0.8 1.0 2.6 -1.0 0.6 1.6 0.5
Shortness of breath walking on level ground 0.1 0.1 0.3 -0.2 -0.5 -0.1 -0.0
Qualifications: College or University degree 0.1 0.2 0.7 -0.3 -0.5 0.8 0.1
Eye problems/disorders: None of the above 1.1 1.2 3.0 0.6 -1.2 -0.3 -1.7
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.8 1.7 -0.3 -0.5 -0.7
Emphysema/chronic bronchitis 0.3 0.4 1.2 1.1 -0.1 0.2 -0.5
Medication for pain relief, constipation, heartburn 0.4 0.7 2.0 0.5 1.4 -0.1 -0.6
Neck or shoulder pain in last month 1.2 1.7 3.0 1.6 0.9 -0.6 -1.7
Medication: Blood pressure 0.4 0.7 1.1 -0.7 0.2 1.0 -1.1
Angina (self-reported) 1.0 1.3 4.3 2.1 -0.7 -0.5 -0.1
Migraine (self-reported) 0.4 0.5 1.4 -0.7 0.1 1.2 0.3
Medication: Ibuprofen 1.0 1.2 4.4 -0.5 0.4 2.1 0.2
Medication: Allopurinol 0.1 0.1 0.3 -0.1 -0.5 -0.1 -0.3
Medication: Omeprazole 1.1 1.3 2.4 1.1 -1.6 -0.8 -0.9
Medication: Seretide 50 evohaler 1.9 2.1 3.4 -1.0 1.2 1.8 1.6
Mean time to correctly identify matches 0.1 0.1 0.5 -0.7 -0.0 -0.1 -0.2
Heart disease (mother) 0.3 0.3 1.0 1.0 -0.4 0.1 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.3 0.2 1.2 -0.5 0.8
Whole body fat mass 2.5 10.6 17.6 3.0 -3.4 -2.0 -4.2
Leg fat mass (right) 2.9 11.2 17.1 3.4 -3.5 -1.9 -4.1
Arm predicted mass (right) 1.7 8.8 13.5 3.6 -1.9 -2.3 -3.7
Pulse rate, automated reading 0.8 2.7 3.8 -1.9 1.0 1.8 1.7
Alcohol intake frequency. 1.7 4.0 9.1 -3.0 1.9 -1.9 -0.1
Comparative height size at age 10 0.2 1.2 2.8 -0.3 -1.2 -1.7 -0.5
Number of full sisters 0.9 1.1 2.6 1.6 0.7 -0.6 -1.0
Suffer from ‘nerves’ 0.6 0.9 3.3 0.3 0.1 -1.8 0.3
Overall health rating 0.5 1.0 2.9 0.6 -0.7 0.5 -1.7
Chest pain or discomfort 0.1 0.2 0.6 0.8 0.3 -0.4 -0.2
Had major operations 0.7 0.8 2.3 -0.6 -1.5 0.4 0.7
Age at last live birth 0.5 0.7 1.2 1.1 -1.0 -0.6 -0.5
Family relationship satisfaction 1.4 1.7 5.5 -0.5 0.8 0.6 2.4
Leg pain on walking 0.2 0.3 1.0 -0.3 -0.2 -1.0 0.2
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 1.9 -0.8 1.4 1.0 1.3
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.6 0.1 0.3 1.6 0.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 0.5 -0.3 0.3 0.2
Medication: Aspirin 0.3 0.3 0.8 -0.3 -0.9 -0.2 0.7
Supplements: Vitamin C 1.8 2.1 4.6 -2.1 -0.3 0.6 1.8
Knee pain experienced in last month 2.3 3.6 10.6 1.4 -1.3 -0.2 -3.2
Hypertension (Self-reported) 0.5 1.3 2.2 0.5 -0.9 1.4 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.6 1.3 0.2 -0.0 -0.9
Illnesses of father: Heart disease 0.3 0.5 1.5 -0.3 -0.6 -1.2 -0.0
Illnesses of siblings: Diabetes 1.9 2.4 4.7 2.2 0.2 0.0 -2.2
Smoking status: Previous 0.4 0.6 1.5 -0.6 0.5 1.2 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.5 -1.6 -0.8 -0.6 0.0
Whole body fat-free mass 1.3 7.5 11.9 2.9 -1.9 -2.5 -3.5
Leg fat-free mass (right) 1.6 8.6 14.7 2.8 -2.5 -2.4 -3.8
Arm fat percentage (left) 1.9 7.5 14.4 2.4 -2.6 -1.7 -3.8
Average weekly red wine intake 0.5 0.7 2.0 -0.2 -1.4 0.7 0.5
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 -0.2 -0.4 0.1 0.1
Mood swings 1.1 1.9 3.7 -1.6 0.7 -1.9 1.0
Loneliness, isolation 1.1 1.6 3.3 -0.4 1.7 -0.1 1.8
Long-standing illness, disability or infirmity 0.9 1.4 2.2 -1.5 1.3 1.1 0.5
Ever had bowel cancer screening 0.4 0.4 1.1 1.1 0.5 0.5 0.2
Diabetes diagnosed by doctor 1.3 2.2 5.1 -0.5 2.2 1.3 1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.8 0.9 0.1 0.7 0.2
Friendships satisfaction 0.9 1.1 2.1 1.3 -0.7 -0.4 1.4
Qualifications: nursing, teaching 0.4 0.7 1.3 1.1 -1.1 0.4 -0.4
Commuting to job workplace: Walk 0.6 0.6 1.2 0.0 1.0 0.6 1.1
Eye problems/disorders: Cataract 1.1 1.3 4.6 0.7 0.3 -2.1 0.0
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 3.1 -1.8 0.5 -0.0 0.2
Medication for cholesterol 0.7 1.0 3.0 0.3 1.0 -1.7 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 5.9 -0.5 0.7 0.1 2.4
Back pain experienced in last month 0.5 0.8 2.2 0.7 -1.5 -0.1 -0.7
Mineral and other dietary supplements 0.5 0.6 2.0 0.4 0.5 0.2 -1.4
Breast cancer (self-reported) 1.8 2.2 4.7 -0.3 1.3 1.4 2.2
Asthma (self-reported) 3.6 7.1 9.0 -2.7 2.2 2.7 3.0
Osteoporosis (self-reported) 0.3 0.3 1.0 0.5 -0.1 0.4 -1.0
Osteoarthritis (self-reported) 0.4 0.5 1.2 1.1 0.8 0.1 -0.6
Medication: Aspirin 0.3 0.5 1.0 -0.1 -1.0 -0.5 0.8
Medication: Gliclazide 0.4 0.5 0.9 -0.7 -1.0 -0.5 0.5
Illnesses of father: None of the above (group 1) 0.3 0.3 0.9 -0.1 -0.6 0.0 -1.0
Smoking status: Current 0.3 0.4 1.1 1.1 -0.6 0.2 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 4.0 0.9 -1.7 -2.0 -0.4
Whole body water mass 1.3 7.2 11.8 2.9 -1.8 -2.4 -3.4
Leg predicted mass (right) 1.6 8.7 15.1 2.9 -2.4 -2.4 -3.9
Arm fat mass (left) 2.5 10.3 18.5 3.1 -2.9 -2.2 -4.3
Number of self-reported non-cancer illnesses 1.0 1.7 3.5 -1.3 1.2 1.9 0.5
Average weekly champagne plus white wine intake 0.4 0.6 1.3 0.7 0.6 0.6 1.1
Miserableness 1.1 1.9 5.7 -0.8 2.4 -0.2 1.0
Guilty feelings 2.0 3.0 11.4 -0.9 3.4 0.1 -0.1
Wears glasses or contact lenses 0.4 0.5 1.9 -0.1 -1.4 -0.3 0.1
Ever taken oral contraceptive pill 0.6 0.6 1.2 0.9 -0.5 -0.6 -1.1
Hearing aid user 0.6 0.6 1.3 1.1 -0.6 0.8 0.4
Mother’s age at death 1.6 2.0 2.6 -1.5 0.9 1.5 1.6
Financial situation satisfaction 0.6 0.7 2.2 1.5 0.6 -0.2 0.4
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.9 0.4 0.9 1.4 0.1
Commuting to job workplace: Public transport 0.9 1.1 3.6 0.7 0.5 -1.9 -0.4
Eye problems/disorders: Glaucoma 0.2 0.2 0.3 0.6 -0.4 -0.1 0.5
Medication: Blood pressure 0.4 0.8 1.7 0.9 -0.8 1.3 0.4
Pain type(s) experienced in last month: Hip pain 3.9 4.9 6.2 2.4 -2.2 -1.7 -2.5
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.7 0.0 -1.6 0.6 1.0
High cholesterol (Self-reported) 0.8 1.5 3.3 -1.3 -1.8 -0.7 -0.6
Medication: Bendroflumethiazide 0.6 0.9 1.9 0.0 -1.4 -0.6 -1.2
Medication: Paracetamol 0.0 0.0 0.0 -0.1 -0.1 -0.2 0.1
Medication: Lisinopril 0.2 0.2 0.5 -0.4 -0.7 -0.1 -0.5
Medication: Atorvastatin 1.2 1.4 4.5 -0.2 -0.9 -2.1 -0.6
Illnesses of father: High blood pressure 0.9 1.2 2.3 -1.5 0.0 1.2 0.9
Alcohol drinker status: Never 2.5 3.0 5.2 -2.3 2.2 0.2 1.3
Ever smoked 0.2 0.4 1.0 0.6 -0.1 1.0 0.4
Basal metabolic rate 1.6 8.7 14.4 3.0 -2.2 -2.5 -3.8
Leg fat percentage (left) 2.6 9.5 14.1 3.2 -3.4 -1.5 -3.8
Arm fat-free mass (left) 1.4 7.3 11.2 3.3 -1.8 -2.1 -3.3
Number of operations (self-reported) 2.4 3.6 5.3 -1.7 1.4 2.0 2.3
Average weekly beer plus cider intake 2.0 2.8 9.9 3.1 -0.3 0.7 -0.9
Irritability 1.9 3.2 6.0 -2.4 0.6 -0.7 2.4
Risk taking 0.4 0.6 1.3 -0.9 -0.3 1.2 -0.6
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.7 -0.8 1.3 -0.9 0.2
Fractured/broken bones in last 5 years 1.0 1.2 2.6 0.1 1.6 1.5 0.5
Age started oral contraceptive pill 2.8 3.5 12.7 3.6 -0.4 -0.7 -0.8
Diastolic blood pressure, automated reading 0.2 0.6 1.8 -0.1 -0.6 1.4 -0.6
Ever depressed for a whole week 2.2 2.7 4.4 -1.2 2.1 1.0 2.1
Unable to work because of sickness or disability 1.8 2.3 6.0 0.5 -0.7 -1.6 -2.4
Commuting to job workplace: Cycle 0.5 0.6 2.1 0.7 -0.0 0.2 1.4
Myopia 0.6 0.9 1.9 -0.3 -1.4 -1.2 0.4
Vascular/heart problems diagnosed by doctor 0.6 1.5 2.7 -0.7 1.6 -0.6 1.6
Cholesterol lowering medication 1.2 1.8 2.4 1.2 -1.6 -1.0 -1.5
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 2.1 1.3 -1.5 -1.3 -0.9
Pain experienced in last month 0.6 0.9 1.4 -1.2 0.9 0.3 1.2
Supplements: Calcium 1.2 1.3 3.1 -0.8 1.1 0.7 1.8
Basal cell carcinoma (self-reported) 0.5 0.6 1.1 -0.1 1.0 1.1 0.6
Heart attack/myocardial infarction (self-reported) 1.6 2.1 4.6 -0.4 -1.7 -1.0 -2.1
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.4 0.1 -0.0 0.5 1.2
Heart disease (siblings) 0.3 0.4 1.3 0.5 -0.3 0.1 -1.1
Alcohol drinker status: Previous 0.7 0.8 2.0 -1.0 1.4 -0.1 -0.1
Pack years of smoking 0.7 1.0 1.9 1.4 -0.9 0.3 -1.1
Impedance of whole body 0.9 4.7 10.4 -3.2 -0.6 -0.0 2.8
Leg fat mass (left) 3.2 12.4 19.6 3.7 -3.6 -2.0 -4.4
Arm predicted mass (left) 1.7 8.5 12.7 3.5 -1.9 -2.2 -3.6