Best TWAS P=2.56e-10 · Best GWAS P=3.9e-11 conditioned to 0.0488
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | GNA12 | 0.24 | 0.13 | enet | 20 | 0.22 | 3.5e-17 | -6.2 | -6.3 | 3.3e-10 | 0.85 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | GNA12 | 0.46 | 0.51 | lasso | 5 | 0.50 | 7.9e-19 | -5.9 | -5.9 | 3.9e-09 | 0.91 | 0.12 | 0.88 | FALSE |
| 3 | GTEx | Colon Sigmoid | GNA12 | 0.14 | 0.05 | lasso | 3 | 0.03 | 3.6e-02 | -4.7 | -5.6 | 1.7e-08 | 0.85 | 0.03 | 0.90 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | GNA12 | 0.20 | 0.12 | lasso | 6 | 0.12 | 3.4e-05 | -4.5 | -5.5 | 4.2e-08 | 0.86 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Esophagus Mucosa | GNA12 | 0.16 | 0.13 | lasso | 3 | 0.13 | 3.0e-09 | -6.1 | -6.0 | 1.4e-09 | 0.90 | 0.03 | 0.97 | FALSE |
| 6 | GTEx | Esophagus Muscularis | GNA12 | 0.32 | 0.31 | lasso | 3 | 0.34 | 2.1e-21 | -6.2 | -6.1 | 8.2e-10 | 0.94 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Nerve Tibial | GNA12 | 0.31 | 0.34 | lasso | 7 | 0.36 | 9.6e-27 | -4.5 | -5.6 | 2.0e-08 | 0.85 | 0.92 | 0.08 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | GNA12 | 0.17 | 0.16 | lasso | 3 | 0.18 | 1.3e-14 | -4.5 | -5.6 | 2.4e-08 | 0.86 | 0.20 | 0.80 | FALSE |
| 9 | GTEx | Whole Blood | GNA12 | 0.09 | 0.01 | enet | 4 | 0.00 | 3.3e-01 | -6.0 | -5.8 | 5.8e-09 | 0.93 | 0.02 | 0.91 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | AMZ1 | 0.09 | 0.05 | lasso | 6 | 0.04 | 2.4e-06 | -6.2 | 6.3 | 2.6e-10 | -0.93 | 0.01 | 0.99 | TRUE |