Best TWAS P=1.84e-10 · Best GWAS P=3.24e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | IRF5 | 0.16 | 0.08 | lasso | 4 | 0.08 | 8.2e-05 | 6.3 | 6.2 | 4.9e-10 | 0.99 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Colon Transverse | IRF5 | 0.21 | 0.22 | lasso | 4 | 0.22 | 8.0e-11 | 6.3 | 6.3 | 3.7e-10 | 1.00 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Esophagus Mucosa | IRF5 | 0.13 | 0.14 | lasso | 4 | 0.13 | 4.6e-09 | 6.3 | 6.2 | 5.1e-10 | 1.00 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | IRF5 | 0.21 | 0.12 | lasso | 5 | 0.11 | 3.9e-07 | 6.3 | 5.7 | 9.6e-09 | 0.95 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Nerve Tibial | IRF5 | 0.13 | 0.09 | enet | 10 | 0.07 | 1.2e-05 | 6.3 | 6.2 | 4.4e-10 | 0.95 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | IRF5 | 0.10 | 0.14 | lasso | 2 | 0.12 | 1.9e-10 | 6.3 | 6.4 | 2.1e-10 | 1.00 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Thyroid | IRF5 | 0.14 | 0.10 | enet | 6 | 0.11 | 1.2e-08 | 6.3 | 5.6 | 2.7e-08 | 0.85 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Whole Blood | IRF5 | 0.17 | 0.06 | lasso | 4 | 0.09 | 1.2e-08 | -4.0 | 5.7 | 1.3e-08 | 0.91 | 0.00 | 1.00 | FALSE |
| 9 | METSIM | Adipose | IRF5 | 0.05 | 0.04 | lasso | 7 | 0.04 | 2.2e-06 | 6.3 | 5.5 | 4.6e-08 | 0.95 | 0.00 | 1.00 | FALSE |
| 10 | YFS | Blood | TNPO3 | 0.37 | 0.31 | enet | 32 | 0.36 | 7.4e-125 | 4.7 | -5.3 | 9.2e-08 | -0.72 | 0.85 | 0.15 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IRF5 | 0.10 | 0.09 | lasso | 4 | 0.08 | 1.6e-16 | 6.3 | 6.2 | 5.5e-10 | 0.99 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | IRF5 | 0.29 | 0.26 | enet | 6 | 0.29 | 3.1e-17 | -5.8 | 6.2 | 4.4e-10 | 0.95 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IRF5 | 0.14 | 0.12 | enet | 7 | 0.15 | 1.8e-16 | 5.8 | 5.3 | 8.6e-08 | 0.88 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IRF5 | 0.11 | 0.05 | blup | 30 | 0.07 | 2.2e-08 | 6.3 | 5.5 | 4.1e-08 | 0.85 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | IRF5 | 0.09 | 0.04 | lasso | 4 | 0.06 | 2.3e-04 | 6.3 | 6.4 | 1.8e-10 | 0.97 | 0.00 | 1.00 | TRUE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | IRF5 | 0.18 | 0.11 | enet | 9 | 0.14 | 1.6e-15 | 6.3 | 5.5 | 4.4e-08 | 0.90 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | IRF5 | 0.14 | 0.15 | enet | 6 | 0.14 | 7.0e-10 | -5.8 | 5.3 | 1.3e-07 | 0.86 | 0.01 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IRF5 | 0.09 | 0.10 | lasso | 3 | 0.08 | 4.6e-04 | -5.8 | 5.8 | 7.9e-09 | 0.85 | 0.01 | 0.88 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IRF5 | 0.23 | 0.26 | lasso | 3 | 0.26 | 3.6e-27 | -5.8 | 6.2 | 6.2e-10 | 0.92 | 0.01 | 0.99 | FALSE |
| 20 | The Cancer Genome Atlas | Rectum Adenocarcinoma | IRF5 | 0.41 | 0.13 | blup | 33 | 0.23 | 3.5e-06 | -5.8 | 6.0 | 2.1e-09 | 0.89 | 0.00 | 0.98 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | IRF5 | 0.22 | 0.21 | enet | 9 | 0.26 | 4.6e-25 | -5.8 | 5.9 | 4.0e-09 | 0.92 | 0.00 | 1.00 | FALSE |