Best TWAS P=1.23e-13 · Best GWAS P=6.77e-17 conditioned to 0.0041
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | CD274 | 0.44 | 0.36 | lasso | 4 | 0.26 | 2.4e-07 | 5.7 | -5.6 | 2.1e-08 | -0.08 | 0.95 | 0.00 | TRUE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | KIAA1432 | 0.05 | 0.00 | blup | 502 | 0.02 | 7.5e-04 | 2.1 | 6.0 | 2.3e-09 | 0.55 | 0.07 | 0.42 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | IGHEP2 | 0.08 | 0.07 | enet | 12 | 0.08 | 3.7e-10 | 7.2 | -7.4 | 1.2e-13 | -0.91 | 1.00 | 0.00 | TRUE |
| 4 | YFS | Blood | JAK2 | 0.03 | 0.03 | lasso | 4 | 0.03 | 1.4e-10 | -4.6 | 6.3 | 3.0e-10 | 0.72 | 0.99 | 0.01 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | JAK2 | 0.07 | 0.00 | blup | 83 | 0.02 | 2.2e-03 | 7.0 | 5.2 | 2.5e-07 | 0.70 | 0.03 | 0.08 | FALSE |