TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Ulcerative Colitis (UC)
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chr9:4,287,179-6,472,714
Best TWAS P=1.23e-13 · Best GWAS P=6.77e-17 conditioned to 0.0041
4.5M
5M
5.5M
6M
6.5M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
ROSMAP
Brain Pre-frontal Cortex
IGHEP2
0.08
0.07
enet
12
0.08
3.7e-10
7.2
-7.4
1.2e-13
-0.91
1.00
0.00
TRUE
1
GTEx
Brain Cerebellar Hemisphere
CD274
0.44
0.36
lasso
4
0.26
2.4e-07
5.7
-5.6
2.1e-08
-0.08
0.95
0.00
TRUE
4
YFS
Blood
JAK2
0.03
0.03
lasso
4
0.03
1.4e-10
-4.6
6.3
3.0e-10
0.72
0.99
0.01
FALSE
2
ROSMAP
Brain Pre-frontal Cortex
KIAA1432
0.05
0.00
blup
502
0.02
7.5e-04
2.1
6.0
2.3e-09
0.55
0.07
0.42
FALSE
5
The Cancer Genome Atlas
Lung Adenocarcinoma
JAK2
0.07
0.00
blup
83
0.02
2.2e-03
7.0
5.2
2.5e-07
0.70
0.03
0.08
FALSE