TWAS hub - SH2B1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0470	0.0300	1.7e-03	0.038	0.022	0.025	0.026	0.032	1.6e-05	1.0e-03	3.9e-04	3.7e-04	7.4e-05
2	GTEx	Adipose Subcutaneous	0.0470	0.0220	6.4e-05	0.094	NA	0.038	NA	0.083	4.5e-08	NA	3.9e-04	NA	2.7e-07
3	GTEx	Adipose Visceral Omentum	0.0620	0.0350	2.7e-03	0.057	NA	0.034	NA	0.045	6.2e-04	NA	6.8e-03	NA	2.3e-03
4	GTEx	Artery Coronary	0.1000	0.0530	7.1e-03	0.089	NA	-0.003	NA	0.026	6.5e-04	NA	4.1e-01	NA	4.5e-02
5	GTEx	Breast Mammary Tissue	0.0640	0.0310	1.0e-03	0.070	NA	0.049	NA	0.061	1.9e-04	NA	1.5e-03	NA	4.4e-04
6	GTEx	Breast Mammary Tissue (Female)	0.0904	0.0447	1.7e-03	0.049	NA	0.008	NA	-0.005	1.4e-02	NA	1.8e-01	NA	5.1e-01
7	GTEx	Esophagus Gastroesophageal Junction	0.1240	0.0570	3.3e-04	0.067	NA	0.127	NA	0.135	2.0e-03	NA	2.5e-05	NA	1.4e-05
8	GTEx	Esophagus Mucosa	0.0860	0.0400	4.2e-05	0.032	NA	0.026	NA	0.029	3.2e-03	NA	6.9e-03	NA	4.9e-03
9	GTEx	Esophagus Muscularis	0.0640	0.0290	1.3e-04	0.029	NA	0.059	NA	0.051	6.8e-03	NA	1.9e-04	NA	4.6e-04
10	GTEx	Heart Left Ventricle	0.0376	0.0209	5.6e-03	0.070	NA	0.010	NA	0.066	1.4e-04	NA	9.1e-02	NA	2.2e-04
11	GTEx	Lung	0.0373	0.0201	2.7e-03	0.071	NA	0.058	NA	0.062	4.3e-06	NA	3.2e-05	NA	1.7e-05
12	GTEx	Nerve Tibial	0.0620	0.0328	5.4e-04	0.034	NA	0.009	NA	0.025	1.8e-03	NA	6.7e-02	NA	6.4e-03
13	GTEx	Prostate	0.0860	0.0460	8.0e-03	0.007	NA	-0.008	NA	0.002	2.0e-01	NA	5.9e-01	NA	2.9e-01
14	GTEx	Stomach	0.0480	0.0260	5.3e-03	0.042	NA	0.032	NA	0.023	4.2e-03	NA	1.2e-02	NA	2.6e-02
15	METSIM	Adipose	0.0711	0.0251	2.1e-13	0.116	0.098	0.106	0.102	0.113	6.8e-17	1.6e-14	1.3e-15	4.5e-15	1.4e-16
16	ROSMAP	Brain Pre-frontal Cortex	0.0269	0.0154	1.2e-03	0.000	0.012	0.004	0.009	0.002	3.5e-01	8.2e-03	8.6e-02	2.1e-02	1.8e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16
Arm fat percentage (left)	40.2	160.3	187.7	13.1	-13.0	-12.2	-11.2	-13.2	-12.3	-12.4	-13.7	-12.8	-12.6	-11.2	-12.6	-12.6	-13.0	-13.2	-13.2
Arm fat percentage (right)	40.1	158.1	182.2	13.0	-13.0	-12.2	-11.0	-13.1	-12.3	-12.4	-13.5	-12.6	-12.6	-11.1	-12.5	-12.5	-12.9	-13.1	-13.1
Trunk fat percentage	39.3	157.6	190.4	13.3	-13.2	-11.7	-11.2	-13.1	-12.0	-12.0	-13.8	-12.7	-12.3	-11.0	-12.3	-12.5	-13.1	-13.4	-12.9
Trunk fat mass	39.1	168.0	193.2	13.5	-13.5	-12.3	-11.5	-13.5	-12.6	-12.3	-13.9	-13.2	-12.9	-11.5	-12.9	-12.9	-13.5	-13.6	-13.5
Hip circumference	37.7	162.2	182.2	13.0	-13.0	-12.4	-11.1	-13.1	-12.5	-12.5	-13.5	-13.3	-12.8	-11.3	-12.8	-12.6	-13.0	-13.2	-13.4
Waist circumference	37.3	136.5	158.8	12.1	-12.1	-11.4	-10.2	-12.1	-11.3	-11.0	-12.6	-12.1	-11.5	-10.2	-11.6	-11.5	-12.0	-12.3	-12.6
Arm fat mass (right)	37.2	153.1	171.6	12.7	-12.7	-11.9	-10.9	-12.9	-12.2	-12.0	-13.1	-12.5	-12.5	-11.1	-12.3	-12.3	-12.8	-12.8	-13.0
Whole body fat mass	37.1	154.9	176.9	12.8	-12.8	-11.9	-11.0	-12.9	-12.2	-12.1	-13.3	-12.7	-12.5	-11.1	-12.4	-12.4	-12.9	-12.9	-13.0
Arm fat mass (left)	37.0	151.9	171.6	12.7	-12.7	-11.9	-10.7	-12.8	-12.1	-11.9	-13.1	-12.5	-12.4	-11.0	-12.3	-12.3	-12.7	-12.8	-13.0
Body fat percentage	35.4	139.8	166.4	12.3	-12.3	-11.4	-10.5	-12.3	-11.4	-11.4	-12.9	-12.0	-11.6	-10.4	-11.7	-11.7	-12.2	-12.5	-12.3
Alcohol intake frequency.	33.6	78.1	88.1	8.8	-8.8	-8.8	-7.8	-9.3	-9.0	-9.4	-9.1	-8.9	-9.2	-8.1	-8.9	-8.9	-9.0	-8.7	-8.6
Leg fat mass (left)	29.8	116.4	130.0	10.9	-10.9	-10.7	-9.5	-11.1	-10.7	-10.5	-11.3	-11.0	-10.9	-9.8	-10.8	-10.8	-11.0	-11.1	-11.4
Intelligence (Savage-Jansen 2018)	29.5	90.7	121.0	-10.3	10.1	8.9	8.7	10.0	8.9	9.7	11.0	10.1	9.0	8.4	9.0	9.1	10.1	9.9	8.8
Weight	29.2	143.3	163.8	12.2	-12.2	-11.5	-10.4	-12.4	-11.9	-11.3	-12.4	-12.1	-12.2	-10.9	-12.2	-12.0	-12.4	-12.4	-12.8
Leg fat mass (right)	28.9	112.0	125.4	10.7	-10.7	-10.4	-9.3	-10.8	-10.5	-10.4	-11.2	-10.8	-10.7	-9.6	-10.5	-10.6	-10.9	-10.8	-11.2
BMI	28.2	163.3	179.6	13.2	-13.2	-12.9	-11.1	-13.3	-12.6	-12.1	-13.4	-13.1	-12.9	-11.4	-12.7	-12.6	-13.2	-13.2	-13.3
Body mass index (BMI)	25.8	110.1	123.3	10.7	-10.7	-10.5	-9.1	-10.9	-10.4	-10.2	-11.1	-10.7	-10.7	-9.3	-10.4	-10.4	-10.7	-10.8	-11.1
Irritable Bowel Disease (IBD)	23.6	56.3	64.3	7.5	-7.5	-7.0	-7.5	-7.5	-7.9	-7.6	-8.0	-7.5	-7.8	-7.7	-7.2	-7.8	-7.9	-7.3	-6.2
Crohns Disease (2017)	21.1	46.2	53.7	6.9	-6.9	-6.6	-6.6	-7.0	-7.1	-6.9	-7.3	-6.6	-7.1	-6.7	-6.2	-7.0	-7.2	-6.8	-5.7
Leg fat percentage (left)	20.8	75.1	86.3	8.9	-8.8	-8.8	-7.8	-9.0	-8.3	-8.2	-9.3	-9.0	-8.5	-7.6	-8.6	-8.5	-8.8	-9.0	-9.3
Body Mass Index (BMI) (2010)	20.2	27.7	39.5	0.0	-6.3	-5.3	-4.5	-5.9	-5.2	-6.1	0.0	-6.2	-5.2	-4.9	-5.5	-5.5	-6.1	-6.3	-5.7
Verbal and Numeric Reasoning (VNR)	20.0	48.1	55.4	-7.4	7.4	7.0	6.6	7.2	6.9	6.1	7.4	6.8	7.0	6.4	6.8	6.8	7.4	7.2	6.4
Comparative body size at age 10	19.7	54.4	71.1	8.3	-8.2	-6.3	-6.3	-7.4	-6.8	-6.9	-8.4	-7.8	-6.9	-6.3	-7.0	-7.2	-8.1	-8.0	-7.5
Crohns Disease (2012)	19.6	31.6	40.5	6.0	-5.9	-5.5	-5.3	-6.1	-6.1	-6.4	0.0	-5.5	-6.1	-5.7	-5.1	-6.0	-6.2	-5.9	-5.3
Leg predicted mass (left)	19.3	102.4	114.5	10.4	-10.4	-9.3	-8.8	-10.3	-10.3	-9.5	-10.4	-10.1	-10.4	-9.4	-10.1	-10.3	-10.7	-10.5	-10.7
Leg fat percentage (right)	19.1	69.3	79.3	8.5	-8.4	-8.4	-7.5	-8.5	-8.1	-8.1	-8.9	-8.6	-8.2	-7.4	-8.2	-8.3	-8.5	-8.6	-8.8
Leg fat-free mass (left)	19.0	100.8	112.4	10.3	-10.3	-9.3	-8.8	-10.2	-10.2	-9.5	-10.3	-10.0	-10.4	-9.4	-10.1	-10.2	-10.6	-10.4	-10.6
Fluid intelligence score	17.7	36.8	43.6	-6.4	6.4	6.5	5.7	6.5	5.9	5.7	6.6	6.2	6.1	5.4	5.9	5.8	6.3	6.1	5.5
Leg fat-free mass (right)	17.7	94.3	108.2	10.0	-10.0	-9.1	-8.4	-10.0	-9.8	-9.0	-9.9	-9.5	-10.0	-9.0	-9.8	-9.8	-10.3	-10.1	-10.4
Leg predicted mass (right)	17.6	94.0	108.2	10.0	-10.0	-9.0	-8.4	-9.9	-9.8	-8.9	-9.9	-9.5	-10.0	-9.0	-9.8	-9.8	-10.2	-10.1	-10.4
Suffer from ‘nerves’	17.1	26.8	34.8	5.3	-5.3	-4.8	-4.8	-5.3	-5.3	-5.8	-5.9	-5.2	-5.4	-4.8	-5.0	-5.0	-5.3	-5.1	-4.2
Qualifications: College or University degree	15.1	47.7	57.4	-7.1	7.1	6.9	5.4	7.1	6.7	6.9	7.4	7.6	6.9	6.2	6.7	7.0	7.1	7.1	7.0
Qualifications: None of the above	14.2	30.4	37.3	5.7	-5.7	-6.1	-4.8	-5.7	-5.4	-5.4	-5.7	-5.5	-5.5	-5.0	-5.4	-5.5	-5.6	-5.7	-5.3
Basal metabolic rate	13.7	76.0	91.2	8.8	-8.8	-8.3	-7.5	-8.9	-8.9	-8.0	-8.7	-8.8	-9.1	-8.1	-9.0	-8.8	-9.1	-8.9	-9.6
Ulcerative Colitis (UC)	11.7	22.0	27.6	4.6	-4.6	-4.2	-5.3	-4.6	-4.9	-4.5	-5.0	-4.9	-4.8	-4.9	-4.7	-4.8	-4.8	-4.5	-3.9
Handedness (chirality/laterality): Left-handed	10.3	12.4	16.8	3.8	-3.9	-4.1	-3.1	-3.8	-3.4	-3.1	-3.9	-3.1	-3.6	-2.9	-3.3	-3.3	-3.7	-3.7	-3.4
Serious illness, injury or assault of a close relative in last 2 years	10.2	11.8	15.6	-3.7	3.7	3.0	2.4	3.3	3.5	3.5	3.9	3.4	3.3	3.5	3.3	3.6	4.0	3.4	3.1
Allergy or Eczema	9.6	25.4	39.6	-5.0	5.0	6.3	2.5	5.3	5.3	4.8	4.3	4.2	5.7	4.5	5.3	5.0	4.8	5.0	6.2
Eye problems/disorders: None of the above	9.4	10.9	12.7	3.3	-3.3	-3.0	-2.6	-3.5	-3.5	-3.6	-3.5	-3.4	-3.5	-3.4	-3.2	-3.2	-3.3	-3.0	-3.1
Whole body fat-free mass	9.2	52.7	65.6	7.3	-7.3	-6.9	-6.3	-7.4	-7.5	-6.5	-7.0	-7.3	-7.7	-6.8	-7.6	-7.3	-7.5	-7.3	-8.1
Whole body water mass	8.8	50.3	62.4	7.1	-7.1	-6.8	-6.1	-7.2	-7.4	-6.5	-6.9	-7.1	-7.6	-6.6	-7.4	-7.1	-7.4	-7.2	-7.9
Mean Putamen Volume	8.4	9.6	13.9	-2.9	2.9	3.7	2.8	3.5	3.7	2.7	2.4	2.5	3.7	3.5	3.3	3.3	3.3	2.8	2.1
Comparative height size at age 10	8.2	45.2	51.6	7.1	-7.1	-5.9	-5.9	-7.0	-6.7	-6.7	-7.2	-7.0	-6.8	-6.2	-6.7	-6.6	-7.2	-7.0	-6.1
Medication: Paracetamol	7.8	12.1	14.6	3.6	-3.7	-3.0	-3.6	-3.8	-3.4	-3.0	-3.8	-3.7	-3.8	-2.7	-3.6	-3.2	-3.4	-3.7	-3.5
Pack years adult smoking proportion	7.7	11.7	20.5	3.7	-3.7	-2.7	-3.1	-3.1	-2.7	-4.0	-4.5	-4.5	-2.7	-2.3	-3.2	-2.8	-3.4	-3.6	-3.8
Pulse wave peak to peak time	7.6	8.9	10.9	2.8	-2.8	-2.8	-3.1	-3.0	-3.3	-2.7	-2.9	-3.3	-3.2	-3.1	-2.9	-3.2	-3.0	-2.8	-2.7
Blood Red Count	7.5	72.3	84.3	-8.9	8.9	8.3	7.7	9.0	8.4	7.3	9.2	8.9	8.7	7.5	8.3	8.4	8.8	8.9	8.5
Arm fat-free mass (left)	7.5	38.0	49.7	6.1	-6.1	-6.1	-5.3	-6.3	-6.4	-5.5	-5.9	-6.3	-6.6	-5.7	-6.4	-6.1	-6.4	-6.2	-7.0
Arm predicted mass (left)	7.4	37.4	50.0	6.0	-6.0	-6.2	-5.3	-6.2	-6.3	-5.5	-5.8	-6.2	-6.5	-5.7	-6.3	-6.1	-6.2	-6.1	-7.1
Alcohol usually taken with meals	7.2	11.6	16.5	-3.9	3.8	3.4	3.2	3.8	2.9	3.4	4.1	3.5	3.3	2.2	3.1	2.9	3.5	3.8	3.5
Birth weight of first child	7.2	13.1	16.6	3.9	-3.8	-3.6	-3.0	-3.8	-3.9	-3.8	-3.8	-3.1	-3.8	-3.7	-3.2	-3.7	-4.1	-3.5	-3.0
Alcohol drinker status: Never	7.2	8.6	13.5	3.1	-3.1	-2.7	-2.1	-2.8	-2.8	-3.0	-3.1	-3.1	-3.0	-2.3	-3.0	-2.8	-3.1	-3.1	-3.7
Average weekly champagne plus white wine intake	7.1	9.7	14.7	-2.9	2.9	3.8	2.4	3.2	3.5	3.7	3.0	2.6	3.5	3.3	3.1	3.4	3.0	2.8	2.5
Ulcerative Colitis	7.0	10.1	12.6	3.3	-3.3	-3.2	-3.4	-3.3	-3.5	-2.6	0.0	-3.2	-3.6	-3.4	-3.4	-3.4	-3.4	-3.2	-3.1
Medication: Co-codamol	6.9	7.9	12.6	2.8	-2.8	-2.6	-2.7	-2.4	-2.5	-3.4	-3.4	-3.5	-2.5	-2.4	-2.7	-2.7	-2.7	-2.8	-2.7
Impedance of leg (right)	6.7	32.7	39.4	-5.8	5.8	6.1	4.8	6.0	5.8	5.4	5.6	5.4	6.2	5.1	5.9	5.6	5.8	5.8	6.3
Qualifications: A levels/AS levels or equivalent	6.6	14.5	18.4	-3.6	3.6	3.9	3.8	4.0	4.0	4.3	4.0	3.8	4.0	3.7	3.6	4.0	3.8	3.5	3.4
Average weekly red wine intake	6.6	9.8	13.3	-3.2	3.2	3.2	3.3	3.3	3.0	3.4	3.6	3.2	2.9	2.8	2.8	3.1	3.1	3.0	2.7
Impedance of leg (left)	6.5	31.5	37.1	-5.6	5.6	5.8	4.7	5.8	5.8	5.5	5.5	5.3	6.1	5.2	5.7	5.7	5.8	5.6	6.0
Arm fat-free mass (right)	6.3	32.3	44.8	5.5	-5.5	-5.7	-4.9	-5.8	-5.9	-5.1	-5.3	-5.9	-6.0	-5.3	-6.0	-5.7	-5.8	-5.6	-6.7
Arm predicted mass (right)	6.3	32.2	43.3	5.5	-5.5	-5.6	-5.0	-5.8	-5.9	-5.2	-5.2	-5.8	-6.1	-5.3	-6.0	-5.7	-5.8	-5.6	-6.6
Hand grip strength (right)	6.2	16.9	24.6	-4.4	4.4	4.8	4.4	4.3	3.6	4.3	5.0	4.1	3.8	3.1	3.4	3.8	4.0	4.4	3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.2	13.1	20.3	-3.7	3.7	3.0	3.6	3.6	3.1	4.1	4.5	4.4	2.9	3.1	3.3	3.5	3.7	3.7	3.5
Rheumatoid Arthritis	6.1	8.4	11.6	2.9	-2.9	-2.8	-2.7	-3.1	-2.9	-2.9	0.0	-3.4	-2.9	-2.8	-3.0	-3.0	-3.0	-3.1	-3.4
Number of live births	6.1	8.6	14.5	-3.2	3.2	3.2	1.1	3.6	3.0	2.2	2.5	2.5	3.6	2.0	3.8	2.5	2.7	3.1	3.6
Medication: Paracetamol	6.0	10.0	12.7	3.2	-3.3	-2.6	-3.6	-3.5	-3.2	-2.7	-3.5	-3.5	-3.4	-2.6	-3.2	-3.0	-3.1	-3.2	-2.7
Breastfed as a baby	5.9	7.3	10.6	-3.0	3.0	1.7	2.6	2.9	2.2	2.5	3.2	3.3	2.3	2.1	3.0	2.5	2.9	2.9	2.7
Friendships satisfaction	5.8	7.2	8.3	-2.7	2.7	2.9	2.8	2.8	2.8	2.3	2.7	2.8	2.7	2.7	2.7	2.7	2.8	2.5	2.4
Hayfever, allergic rhinitis or eczema	5.7	12.3	22.0	-3.3	3.3	4.5	1.8	3.6	3.5	3.9	3.2	2.9	3.8	3.0	3.6	3.6	3.2	3.4	4.7
Happiness	5.7	6.9	8.9	-2.9	2.9	2.6	2.6	2.9	2.4	2.1	3.0	2.8	2.5	2.2	2.5	2.5	2.8	2.8	2.5
Eye problems/disorders: Cataract	5.7	6.6	10.9	-2.3	2.3	2.4	2.6	2.8	2.8	3.3	2.8	2.6	2.6	2.9	1.9	2.7	2.4	2.1	2.3
Pulse wave Arterial Stiffness index	5.6	6.6	8.3	-2.3	2.3	2.5	2.8	2.5	2.8	2.3	2.5	2.9	2.8	2.8	2.4	2.8	2.6	2.3	2.3
Qualifications: CSEs or equivalent	5.4	7.1	11.7	2.5	-2.5	-2.7	-2.9	-2.4	-2.5	-3.4	-3.1	-3.4	-2.5	-2.4	-2.3	-2.6	-2.6	-2.6	-1.8
Pack years of smoking	5.4	7.9	14.1	3.1	-3.0	-2.3	-2.3	-2.5	-2.0	-3.2	-3.7	-3.8	-2.2	-1.7	-2.8	-2.1	-2.8	-3.0	-3.4
Ever smoked	5.3	9.4	15.3	-3.0	3.0	2.6	3.9	3.3	2.9	3.0	3.3	3.3	2.9	2.8	2.9	3.1	3.1	2.9	2.6
Medication: Metformin	5.0	7.1	9.9	2.9	-2.9	-1.5	-3.2	-2.7	-2.6	-2.1	-3.1	-2.5	-2.5	-2.7	-2.3	-2.9	-3.0	-2.9	-2.3
Fed-up feelings	5.0	9.0	18.1	3.7	-3.7	-2.5	-2.6	-2.9	-2.6	-2.9	-4.3	-3.0	-2.7	-2.4	-2.1	-2.8	-3.4	-3.6	-2.2
Supplements: Calcium	4.7	5.2	6.8	-2.6	2.6	2.2	1.4	2.3	2.2	1.9	2.6	2.6	2.5	1.7	2.3	2.0	2.5	2.5	2.4
Cardiovascular Disease	4.4	14.6	19.9	3.5	-3.6	-3.9	-4.2	-3.9	-4.3	-3.5	-3.3	-3.2	-4.1	-4.2	-3.6	-4.5	-3.8	-3.8	-3.6
Trunk fat-free mass	4.4	25.4	34.3	4.7	-4.8	-4.9	-4.3	-5.2	-5.5	-4.4	-4.4	-5.2	-5.6	-4.9	-5.6	-5.1	-5.1	-4.8	-5.9
Trunk predicted mass	4.4	25.1	34.0	4.7	-4.7	-4.9	-4.3	-5.1	-5.4	-4.4	-4.4	-5.2	-5.6	-4.9	-5.5	-5.1	-5.0	-4.8	-5.8
Birth weight	4.4	9.5	12.7	3.4	-3.4	-2.6	-2.6	-3.1	-2.9	-2.8	-3.4	-3.2	-3.1	-2.6	-3.0	-2.9	-3.3	-3.3	-3.6
Medication: Gliclazide	4.1	4.7	6.9	2.5	-2.5	-1.3	-2.2	-2.5	-2.2	-1.9	-2.6	-2.1	-2.0	-2.2	-1.6	-2.4	-2.6	-2.3	-1.4
Pulse wave reflection index	4.0	4.9	9.7	-1.8	1.8	1.6	3.1	2.2	2.4	2.1	2.0	2.6	2.2	2.6	2.3	2.5	2.0	1.7	2.1
Smoking status: Previous	4.0	6.0	12.5	-2.3	2.3	2.2	3.5	2.6	2.5	2.5	2.8	2.5	2.5	2.5	1.7	2.6	2.4	2.4	1.6
Ever taken oral contraceptive pill	4.0	4.5	7.2	-2.4	2.4	1.8	1.8	2.3	1.9	1.3	2.0	1.7	1.9	1.8	2.4	2.2	2.4	2.5	2.7
Lung FVC	3.9	20.1	36.5	-4.5	4.5	3.6	6.0	4.4	4.1	3.9	5.0	5.2	3.9	4.1	4.0	4.4	4.7	4.5	4.0
Mouth/teeth dental problems: Loose teeth	3.9	4.7	6.3	2.2	-2.3	-1.8	-2.5	-2.1	-1.9	-1.7	-2.5	-2.5	-1.7	-2.1	-2.0	-2.3	-2.3	-2.3	-2.2
Number of full sisters	3.9	4.8	6.9	-2.0	2.0	2.1	2.1	2.3	2.6	2.5	2.1	2.1	2.6	2.4	2.4	2.2	2.2	1.7	1.4
Hair/balding pattern: Pattern 4	3.8	9.2	12.5	-2.9	2.9	3.2	2.4	3.2	3.5	3.5	2.7	2.3	3.5	3.3	2.9	3.2	3.2	2.8	2.5
Ever depressed for a whole week	3.7	4.6	7.4	-1.9	1.9	2.7	1.7	2.5	2.3	2.4	2.1	2.2	2.0	2.5	1.8	2.5	2.1	1.7	1.7
Hypothyroidism (self reported)	3.6	8.4	18.0	2.8	-2.9	-2.5	-4.2	-3.2	-2.8	-2.4	-2.8	-2.3	-2.3	-3.2	-2.6	-3.2	-2.9	-2.9	-2.6
Age when periods started (menarche)	3.6	8.6	13.1	-3.1	3.1	2.5	1.7	2.8	2.7	3.1	3.5	3.6	3.0	2.2	3.2	2.6	2.8	3.0	3.6
Nervous feelings	3.6	6.7	14.9	2.2	-2.3	-1.9	-3.9	-2.4	-2.6	-3.5	-3.2	-2.4	-2.1	-3.1	-1.5	-2.9	-2.7	-2.0	-1.0
Hayfever/allergic rhinitis (self-reported)	3.6	4.8	13.4	-2.1	2.1	2.8	0.1	2.1	1.9	2.0	1.9	2.2	2.2	1.4	2.3	2.0	1.9	2.3	3.7
Overall health rating	3.5	7.6	15.3	2.3	-2.3	-2.6	-3.9	-2.9	-2.7	-2.7	-2.7	-3.0	-2.8	-2.5	-3.0	-2.9	-2.4	-2.5	-2.6
Miserableness	3.5	6.1	8.6	2.8	-2.9	-2.4	-2.1	-2.2	-2.2	-1.9	-2.9	-2.3	-2.2	-2.1	-2.3	-2.5	-2.8	-2.9	-2.8
Myopia	3.5	5.1	6.8	-2.6	2.5	2.4	2.4	2.3	2.1	2.0	2.5	1.5	1.8	2.5	1.9	2.5	2.6	2.6	1.6
Multivitamins +/- minerals	3.4	4.3	8.1	-2.1	2.1	2.0	1.6	2.0	1.6	2.4	2.4	2.8	1.9	1.1	2.5	1.4	1.8	2.1	2.6
Past tobacco smoking	3.4	6.2	13.1	2.2	-2.2	-2.0	-3.6	-2.7	-2.5	-2.6	-2.8	-2.7	-2.4	-2.5	-2.1	-2.6	-2.4	-2.2	-1.7
Wheeze or whistling in the chest in last year	3.4	6.0	7.6	2.4	-2.4	-2.5	-2.3	-2.5	-2.4	-2.3	-2.6	-2.8	-2.3	-2.5	-2.6	-2.4	-2.4	-2.4	-2.5
Medication: Blood pressure	3.4	6.1	9.8	2.0	-1.9	-2.1	-3.0	-2.8	-2.8	-2.2	-2.2	-2.4	-2.5	-3.0	-2.2	-3.1	-2.2	-2.2	-2.4
Risk taking	3.4	5.0	11.3	-2.5	2.5	0.8	2.9	1.9	1.5	2.6	3.4	2.7	1.3	1.7	1.8	2.1	2.5	2.4	1.7
Long-standing illness, disability or infirmity	3.3	5.1	10.1	2.1	-2.1	-2.2	-3.2	-2.4	-1.8	-2.5	-2.7	-2.5	-1.9	-1.4	-2.3	-1.9	-1.8	-2.3	-2.5
Loneliness, isolation	3.2	4.4	5.4	2.3	-2.3	-2.2	-1.6	-2.3	-2.1	-1.8	-2.2	-1.8	-2.2	-1.9	-2.3	-1.9	-2.1	-2.2	-2.1
Mouth/teeth dental problems: Mouth ulcers	3.2	5.1	7.7	-2.0	2.0	2.0	2.6	2.4	2.2	2.2	2.4	2.8	2.2	2.0	2.3	2.2	1.9	2.1	2.7
Diastolic blood pressure, automated reading	3.2	10.0	14.4	2.9	-2.9	-3.0	-2.9	-3.1	-3.4	-3.3	-3.1	-3.4	-3.3	-3.2	-3.8	-3.2	-3.1	-3.0	-2.9
Alcohol drinker status: Previous	3.2	3.7	4.5	1.9	-1.9	-2.1	-2.0	-2.0	-2.0	-2.1	-2.0	-1.7	-2.0	-1.8	-1.5	-1.9	-1.9	-1.9	-1.9
Bipolar Disorder (2018)	3.1	4.9	8.5	2.7	-2.7	-1.4	-2.2	-2.3	-2.2	-1.7	0.0	-2.5	-2.2	-2.2	-2.2	-2.4	-2.9	-2.6	-1.9
Medication: Aspirin	3.0	3.9	6.4	-1.9	1.9	1.7	1.6	2.0	2.4	2.5	2.1	1.7	2.2	2.5	1.8	2.1	2.2	1.6	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	5.2	2.1	-2.1	-1.7	-1.6	-1.9	-2.0	-2.1	-2.0	-1.2	-1.9	-2.1	-1.5	-2.0	-2.3	-1.9	-1.3
Depressed Affect (Nagel 2018)	2.9	6.2	8.1	2.4	-2.5	-2.5	-2.3	-2.6	-2.5	-2.4	-2.9	-2.5	-2.5	-2.4	-2.4	-2.5	-2.5	-2.5	-2.3
HbA1C	2.9	3.2	5.7	1.7	-1.9	-2.0	-1.2	-1.8	-1.7	-2.4	-2.0	-2.0	-1.7	-1.6	-1.3	-1.6	-1.8	-1.8	-1.7
Family relationship satisfaction	2.9	3.5	6.6	-2.1	2.1	1.2	1.9	1.8	1.7	1.9	2.6	2.0	1.6	1.8	1.6	1.9	2.3	2.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted	2.9	6.1	8.3	2.7	-2.7	-1.4	-2.1	-2.0	-2.5	-2.2	-2.9	-2.8	-2.4	-2.5	-2.8	-2.3	-2.9	-2.6	-2.4
Hypertension (Self-reported)	2.7	7.6	11.7	2.5	-2.5	-2.2	-2.8	-2.7	-3.0	-2.3	-2.3	-2.6	-2.8	-3.1	-2.8	-3.4	-2.7	-2.9	-3.1
Commuting to job workplace: Public transport	2.7	3.3	4.8	-2.0	2.0	1.8	1.7	2.2	1.7	1.5	1.9	1.6	2.0	1.2	1.9	1.5	1.9	2.0	1.8
Alcohol intake versus 10 years previously	2.6	4.0	6.0	2.2	-2.2	-2.4	-1.1	-2.1	-1.9	-1.5	-2.1	-2.0	-1.9	-1.8	-2.0	-2.1	-2.1	-2.1	-1.8
Number of children fathered	2.6	2.9	4.6	-1.9	1.9	2.0	1.4	1.7	1.5	1.0	1.5	1.7	1.3	1.7	1.6	1.9	1.8	2.0	2.1
Chronotype (morning person)	2.5	5.7	12.0	2.0	-1.9	-2.0	-3.5	-2.4	-2.5	-3.0	-2.4	-2.1	-2.1	-3.0	-1.5	-2.9	-2.4	-1.9	-1.6
Systolic blood pressure, automated reading	2.5	7.1	10.5	2.4	-2.4	-2.8	-2.8	-2.9	-2.9	-2.3	-2.4	-2.9	-2.8	-2.7	-3.2	-2.7	-2.6	-2.4	-2.2
High blood pressure	2.5	6.9	10.3	2.4	-2.4	-2.1	-2.7	-2.5	-2.8	-2.3	-2.2	-2.7	-2.5	-3.0	-2.7	-3.2	-2.6	-2.7	-3.2
Allergy	2.5	5.8	12.5	2.1	-2.1	-3.2	-0.9	-2.3	-2.5	-2.7	-2.0	-2.0	-2.5	-2.3	-2.3	-2.7	-2.2	-2.3	-3.5
Lung cancer (father)	2.5	2.9	3.8	1.8	-1.8	-1.9	-1.1	-1.5	-1.7	-1.8	-1.8	-1.9	-1.8	-1.5	-1.9	-1.5	-1.7	-1.6	-1.9
Medication: Atorvastatin	2.5	3.1	4.5	-1.7	1.7	2.1	1.1	2.1	2.0	1.7	1.5	1.0	1.9	1.9	1.6	1.9	1.8	1.6	1.9
Hypothyroidism/myxoedema (self-reported)	2.4	4.7	12.8	1.9	-2.0	-1.9	-3.6	-2.5	-2.1	-2.4	-2.2	-1.7	-1.6	-2.6	-1.8	-2.4	-2.1	-1.9	-1.3
Medication: Amlodipine	2.4	3.4	4.9	1.8	-1.7	-1.5	-2.0	-1.8	-1.8	-1.4	-1.7	-2.0	-1.6	-2.1	-1.9	-2.2	-1.9	-1.8	-2.0
HDL Cholesterol	2.3	3.9	9.0	0.0	2.4	1.5	2.3	1.9	1.5	2.3	0.0	3.0	1.5	1.5	2.1	2.0	2.2	2.5	2.2
Current tobacco smoking	2.3	3.8	5.9	2.3	-2.3	-1.9	-1.2	-1.8	-1.8	-1.9	-2.4	-1.8	-1.9	-1.6	-1.6	-1.8	-2.1	-2.3	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.0	4.6	1.6	-1.6	-1.9	-2.1	-1.8	-1.9	-1.7	-1.7	-1.4	-1.7	-2.0	-1.2	-2.1	-1.8	-1.7	-1.2
Qualifications: O levels/GCSEs or equivalent	2.3	3.6	7.1	-1.8	1.8	2.7	1.9	2.2	1.8	2.4	1.9	1.1	2.0	1.5	1.6	1.8	1.7	1.8	1.9
Qualifications: nursing, teaching	2.3	3.5	5.3	-2.0	2.0	2.3	1.8	1.9	1.8	2.3	2.2	1.5	2.1	1.2	1.8	1.6	1.7	1.9	1.6
Type 2 Diabetes (T2D) (2018)	2.2	4.2	9.6	2.7	-2.6	-1.4	-1.7	-1.9	-1.4	-1.5	-3.1	-2.2	-1.5	-1.1	-1.2	-1.9	-2.3	-2.8	-2.1
Supplements: Zinc	2.2	2.3	4.3	-1.1	1.1	1.5	1.5	1.8	1.9	1.2	0.8	1.5	1.7	2.1	1.7	1.9	1.3	1.1	1.5
Had other major operations	2.2	2.7	6.0	1.1	-1.2	-2.1	-2.5	-1.6	-1.9	-2.1	-1.5	-1.0	-1.7	-2.1	-0.9	-1.8	-1.5	-1.0	-1.1
Medication: Ramipril	2.2	2.9	5.9	1.0	-1.0	-2.0	-1.9	-1.7	-1.8	-1.5	-1.2	-1.8	-1.6	-2.0	-2.0	-2.0	-1.3	-1.2	-2.4
Standing height	2.2	21.4	26.7	4.7	-4.7	-3.5	-4.0	-4.6	-4.9	-3.7	-4.2	-4.6	-4.8	-4.8	-5.2	-5.0	-5.1	-4.7	-5.1
Bipolar Disorder or Schizophrenia	2.1	5.1	8.7	2.7	-2.8	-1.3	-2.3	-2.7	-2.2	-1.4	-2.3	-1.9	-2.1	-2.2	-2.1	-2.3	-3.0	-2.6	-1.4
Hearing difficulty/problems with background noise	2.1	3.3	4.9	-2.2	2.2	1.2	1.5	1.8	1.6	1.3	2.1	2.2	2.0	1.0	1.9	1.2	2.0	2.1	2.1
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.4	6.2	-1.8	1.9	0.9	0.9	1.3	0.6	1.3	2.2	2.5	1.1	-0.1	1.8	0.7	1.4	2.0	2.0
Mood swings	2.1	3.9	5.0	1.8	-1.8	-2.0	-2.2	-1.8	-2.0	-1.9	-2.2	-2.2	-1.9	-2.0	-1.7	-2.2	-2.1	-1.9	-1.6
Medication: Aspirin	2.1	2.7	5.0	-1.6	1.6	1.4	1.4	1.6	2.0	2.2	1.7	1.4	1.8	2.2	1.5	1.8	1.8	1.2	0.6
Smoking status: Current	2.1	3.3	5.0	2.2	-2.2	-1.7	-1.1	-1.6	-1.8	-1.6	-2.2	-1.6	-1.8	-1.6	-1.5	-1.8	-2.0	-2.2	-1.8
Diabetes (self-reported)	2.0	3.1	5.9	2.3	-2.3	-0.7	-2.4	-1.7	-1.1	-1.0	-2.4	-1.6	-1.1	-1.0	-0.9	-1.6	-2.1	-2.4	-1.9
Emphysema/chronic bronchitis	2.0	2.3	4.6	1.4	-1.4	-1.5	-0.7	-1.9	-1.7	-1.0	-1.2	-1.6	-1.9	-1.4	-2.1	-1.5	-1.3	-1.3	-1.7
Commuting to job workplace: Car/motor vehicle	2.0	2.2	3.5	1.5	-1.5	-1.5	-1.1	-1.7	-1.6	-1.9	-1.4	-0.8	-1.7	-1.4	-1.2	-1.6	-1.6	-1.5	-1.6
Osteoporosis (self-reported)	2.0	2.4	4.5	-1.9	1.9	0.5	1.6	1.2	1.2	1.5	2.1	2.1	1.1	1.2	1.6	1.1	2.0	1.7	1.4
Neck or shoulder pain in last month	1.9	2.7	4.9	-1.4	1.3	1.2	1.3	1.5	2.0	1.8	1.6	2.1	1.8	2.2	1.5	1.9	1.8	1.2	1.3
Worry (Nagel 2018)	1.8	3.9	5.7	1.9	-1.9	-1.5	-2.1	-2.0	-2.2	-2.2	-2.2	-1.9	-2.0	-2.4	-1.8	-2.1	-2.2	-1.7	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	4.1	1.7	-1.8	-1.6	-2.0	-1.4	-1.4	-1.7	-2.0	-1.7	-1.4	-1.4	-1.8	-1.6	-1.7	-1.9	-1.9
Vascular/heart problems diagnosed by doctor	1.8	4.9	8.6	-1.9	1.9	2.0	2.2	1.9	2.3	1.8	1.7	2.2	2.1	2.4	2.3	2.7	2.1	2.3	2.9
Neuroticism (Nagel 2018)	1.7	4.1	6.4	2.0	-1.7	-2.1	-2.1	-2.1	-2.2	-2.2	-2.4	-1.6	-2.0	-2.5	-1.7	-2.3	-2.1	-1.6	-1.1
Mother’s age at death	1.7	2.1	4.3	-1.2	1.2	1.6	1.7	1.5	1.4	2.1	1.8	1.9	1.5	1.3	1.2	1.3	1.3	1.1	0.8
Fasting Glucose	1.6	1.9	3.2	1.1	-1.0	-1.8	-1.3	-1.6	-1.6	-1.4	-1.1	-1.1	-1.8	-1.7	-1.5	-1.5	-1.2	-0.9	-0.8
Hand grip strength (left)	1.6	4.1	8.5	-2.3	2.4	2.0	2.3	2.0	1.4	2.0	2.9	2.4	1.6	1.1	1.6	1.6	2.0	2.4	1.7
Illnesses of siblings: Diabetes	1.6	2.0	5.3	2.2	-2.2	0.2	-1.3	-0.9	-0.4	-0.6	-2.2	-0.9	-0.3	-0.6	-0.7	-1.1	-1.9	-2.3	-1.6
Heart attack	1.5	1.9	4.6	1.2	-1.3	-1.4	-0.9	-1.4	-1.3	-1.3	-1.2	-1.5	-1.4	-1.0	-1.4	-1.3	-1.2	-1.5	-2.1
Neuroticism score	1.5	3.1	5.2	1.5	-1.5	-1.9	-2.0	-1.6	-2.1	-1.9	-1.8	-1.5	-2.0	-2.3	-1.5	-2.1	-1.7	-1.4	-0.9
Father’s age at death	1.5	2.1	3.5	-1.4	1.4	1.8	0.9	1.3	1.6	0.9	1.1	1.7	1.4	1.7	1.9	1.7	1.5	1.3	1.3
Medication: Lansoprazole	1.5	1.7	3.5	1.2	-1.2	-1.6	-0.8	-1.4	-1.6	-1.1	-1.1	-0.9	-1.9	-1.3	-1.5	-1.3	-1.2	-1.1	-1.0
Eye problems/disorders: Glaucoma	1.5	1.8	4.1	-1.1	1.1	1.6	0.9	1.6	1.3	0.8	0.8	1.3	1.3	1.2	1.7	1.5	1.3	1.3	2.0
Average weekly beer plus cider intake	1.5	2.1	5.1	1.6	-1.7	-1.9	-0.7	-1.4	-1.0	-1.2	-1.6	-1.7	-1.2	-0.7	-1.4	-0.9	-1.4	-1.7	-2.3
Number of treatments/medications taken	1.4	2.5	5.4	1.6	-1.6	-1.5	-2.3	-1.9	-1.4	-1.1	-1.8	-1.4	-1.4	-1.2	-1.6	-1.6	-1.4	-1.8	-1.3
Number of self-reported non-cancer illnesses	1.4	2.5	8.6	1.4	-1.4	-1.2	-2.9	-1.6	-1.5	-1.2	-1.6	-1.3	-1.4	-1.6	-1.4	-1.8	-1.4	-1.4	-1.0
Alzheimer’s Disease (including proxy)	1.3	1.8	3.2	-1.5	1.6	0.6	1.6	1.1	0.9	0.8	1.7	1.8	0.5	1.1	1.6	1.2	1.6	1.6	1.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	4.2	-0.9	0.8	1.8	2.0	1.7	1.7	1.1	1.0	1.2	1.5	1.9	1.1	2.1	1.0	1.1	1.1
Gout (self-reported)	1.3	1.7	2.6	1.6	-1.6	-1.3	-0.7	-1.5	-1.3	-0.5	-1.3	-1.2	-1.4	-1.1	-1.3	-1.2	-1.6	-1.6	-1.4
Fractured/broken bones in last 5 years	1.3	1.7	3.0	1.1	-1.2	-1.6	-0.7	-1.4	-1.6	-1.6	-1.0	-0.9	-1.7	-1.4	-1.3	-1.4	-1.2	-1.2	-1.0
Blood Platelet Count	1.2	13.6	158.8	-0.3	0.4	-1.0	-12.6	-1.5	-1.9	-3.1	-1.9	-1.9	0.1	-4.8	0.6	-3.1	-1.2	0.4	0.7
Relative age of first facial hair	1.2	2.5	4.9	-1.4	1.4	1.6	1.7	2.2	1.8	1.3	1.3	1.7	1.8	1.6	1.5	1.5	1.6	1.3	0.8
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.7	-1.3	1.3	0.8	0.6	1.3	1.4	0.9	1.4	1.1	1.4	1.4	0.7	1.4	1.7	1.3	0.9
Diabetes (mother)	1.2	1.5	3.0	0.9	-0.9	-1.7	-1.1	-1.3	-1.5	-1.5	-1.0	-1.2	-1.6	-1.3	-1.1	-1.3	-1.0	-0.8	-1.1
Mean time to correctly identify matches	1.2	2.3	4.5	-1.7	1.8	1.5	-0.0	1.7	1.6	1.1	1.2	0.7	2.1	0.9	1.8	1.3	1.5	1.9	1.9
Diabetes diagnosed by doctor	1.2	2.0	5.2	1.9	-1.9	-0.3	-2.3	-1.2	-0.6	-0.4	-2.2	-1.3	-0.6	-0.5	-0.5	-1.2	-1.6	-2.1	-1.5
Heart attack/myocardial infarction (self-reported)	1.2	1.6	4.4	1.1	-1.1	-1.4	-0.8	-1.3	-1.2	-1.2	-1.0	-1.5	-1.3	-0.9	-1.3	-1.1	-1.0	-1.4	-2.1
Neuroticism (2016)	1.1	1.6	3.2	1.1	-1.1	-0.7	-1.8	-0.9	-1.2	-1.6	-1.5	-1.7	-1.3	-1.1	-1.3	-1.1	-1.2	-1.0	-1.2
Relative age voice broke	1.1	1.6	2.7	-1.1	1.2	1.4	0.9	1.4	1.1	1.2	1.3	1.6	0.8	1.5	1.4	1.3	1.3	1.2	1.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.6	-0.7	0.7	1.6	0.6	1.4	1.5	1.0	0.7	0.9	1.1	1.9	0.8	1.8	1.1	0.6	0.7
Worrier / anxious feelings	1.1	2.1	3.2	1.2	-1.2	-1.2	-1.6	-1.4	-1.7	-1.8	-1.6	-1.8	-1.5	-1.7	-1.4	-1.5	-1.4	-1.0	-0.7
Prospective memory result	1.1	1.4	2.5	1.2	-1.2	-1.2	-1.3	-1.0	-1.3	-0.6	-1.0	-0.7	-1.1	-1.6	-1.3	-1.4	-1.5	-1.2	-0.9
Migraine (self-reported)	1.1	1.3	1.9	-1.3	1.3	1.1	0.9	1.3	1.0	1.2	1.4	1.1	1.3	0.6	1.2	0.8	1.2	1.3	1.0
Pulse rate, automated reading	1.1	3.4	12.7	1.4	-1.4	-0.8	-3.6	-1.4	-1.7	-2.3	-2.4	-2.1	-1.1	-2.4	-1.0	-1.9	-1.8	-1.3	-0.8
Medication: Lisinopril	1.1	1.4	2.6	1.5	-1.5	-1.1	-0.6	-1.4	-1.0	-0.6	-1.3	-0.9	-1.3	-0.6	-1.3	-1.1	-1.1	-1.6	-1.3
Alzheimer’s Disease (in mother)	1.0	1.2	2.0	-1.1	1.1	0.7	1.1	0.8	1.2	0.8	1.3	1.3	1.2	1.1	1.4	1.0	1.1	1.0	0.8
Ever had hysterectomy (womb removed)	1.0	1.1	2.3	-1.1	1.1	0.9	-0.5	1.2	1.1	0.7	0.6	1.0	1.5	0.5	1.4	0.7	0.9	1.1	1.4
Medication for hormone replacement therapy	1.0	1.1	3.7	-1.0	0.9	1.0	0.4	1.3	0.7	0.8	1.0	1.5	1.0	0.3	1.1	0.6	0.8	1.0	1.9
Medication: Levothyroxine sodium	1.0	1.7	7.3	1.1	-1.2	-0.8	-2.7	-1.4	-0.9	-1.5	-1.5	-1.1	-0.4	-1.5	-1.0	-1.4	-1.2	-1.2	-0.9
Had menopause	1.0	1.3	2.9	0.8	-0.8	-1.1	-1.5	-1.1	-1.3	-1.2	-1.0	-0.7	-1.0	-1.7	-1.0	-1.5	-1.1	-0.9	-0.8
Impedance of arm (right)	1.0	4.8	10.3	2.8	-2.8	-0.8	-2.2	-2.1	-1.7	-2.1	-3.2	-1.9	-1.6	-1.8	-1.6	-2.2	-2.6	-2.7	-1.4
Impedance of arm (left)	1.0	4.6	9.7	2.7	-2.6	-0.5	-2.4	-2.0	-1.6	-2.0	-3.1	-1.9	-1.3	-1.9	-1.7	-2.3	-2.6	-2.7	-1.4
Shortness of breath walking on level ground	1.0	1.2	4.0	0.9	-0.9	-1.2	-2.0	-1.0	-1.0	-0.9	-0.9	-1.3	-0.9	-1.0	-1.3	-1.0	-1.0	-0.9	-1.1
Ever had bowel cancer screening	1.0	1.2	2.0	-1.2	1.2	0.6	0.8	0.8	1.0	1.4	1.4	0.9	1.0	0.9	0.9	1.1	1.3	1.1	1.4
Primary Biliary Cirrhosis	0.9	1.3	2.5	-1.1	1.1	1.4	1.2	1.2	1.2	1.6	1.4	0.3	1.2	1.2	0.5	1.1	1.0	0.9	1.1
Height	0.9	17.7	25.8	4.0	-3.9	-4.0	-3.1	-4.3	-4.4	-3.7	-3.5	-4.2	-4.5	-4.1	-5.0	-4.6	-4.3	-4.1	-5.1
Sensitivity / hurt feelings	0.9	1.5	3.0	1.1	-1.1	-1.7	-1.0	-1.3	-1.4	-1.1	-1.1	-0.9	-1.2	-1.5	-1.1	-1.4	-1.2	-1.1	-0.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.9	-0.7	0.7	0.6	0.2	0.9	1.2	1.0	0.7	1.6	1.3	1.0	1.7	0.8	0.7	0.6	0.6
Stomach or abdominal pain in last month	0.9	1.1	3.0	-0.9	0.9	1.0	1.2	0.9	0.8	0.8	1.1	1.3	0.6	1.0	0.7	1.1	1.0	1.2	1.7
Headache pain in last month	0.9	1.6	3.3	1.8	-1.8	-0.5	-1.5	-1.1	-1.0	-0.4	-1.8	-0.6	-0.8	-1.2	-0.3	-1.3	-1.8	-1.8	-0.5
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.9	0.3	-0.3	-1.0	-1.0	-0.8	-1.7	-1.3	-0.3	-0.8	-1.6	-1.7	-0.9	-1.1	-0.7	-0.0	-0.6
Exposure to tobacco smoke outside home	0.9	1.2	3.1	0.9	-0.9	-1.7	-0.3	-1.2	-1.3	-1.1	-0.7	-0.6	-1.4	-1.1	-1.2	-1.3	-0.8	-1.0	-1.1
Number of full brothers	0.9	1.1	2.1	-0.9	0.9	0.7	0.8	0.9	1.2	0.5	0.7	1.4	1.2	1.2	1.4	1.2	1.0	0.9	1.1
Health satisfaction	0.9	1.2	2.6	-1.3	1.2	0.3	0.6	1.0	1.3	0.9	1.2	0.8	1.1	1.6	0.6	1.4	1.6	1.0	0.2
Chest pain or discomfort	0.9	1.4	3.5	1.1	-1.1	-1.2	-0.9	-0.9	-1.0	-1.4	-1.2	-1.2	-0.9	-0.9	-1.2	-1.1	-1.2	-1.1	-1.9
Depression (Nagel 2018)	0.8	1.3	2.2	0.8	-0.8	-1.5	-1.3	-1.2	-1.3	-1.5	-1.1	-0.8	-1.3	-1.2	-0.9	-1.1	-1.0	-0.9	-0.9
Vitamin and mineral supplements	0.8	1.1	2.8	0.6	-0.6	-1.4	-0.5	-0.9	-0.9	-1.7	-1.0	-1.6	-1.1	-0.5	-1.5	-0.6	-0.6	-0.6	-1.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.3	0.7	-0.7	-1.4	-1.0	-1.1	-0.8	-1.1	-1.0	-1.5	-0.9	-0.5	-1.1	-0.7	-0.5	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	8.3	-1.1	1.2	1.4	2.9	1.6	1.2	2.4	2.1	2.2	1.0	1.3	1.1	1.4	1.2	1.1	0.7
Glaucoma (self-reported)	0.8	1.0	1.8	-0.9	0.9	1.3	0.8	1.1	0.9	0.9	0.7	0.9	0.8	1.0	1.0	1.0	0.9	0.9	1.3
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.7	0.5	-0.4	-1.1	-1.4	-1.2	-1.3	-1.6	-0.7	-0.7	-1.2	-1.3	-1.3	-1.0	-0.8	-0.5	-0.5
Worry too long after embarrassment	0.8	1.4	3.0	-1.1	1.1	1.5	0.6	1.6	1.3	0.5	0.5	1.0	1.7	0.6	1.6	0.9	0.9	1.2	1.5
Medication: Bendroflumethiazide	0.8	1.1	1.9	1.0	-0.9	-0.8	-1.2	-1.0	-0.9	-0.9	-1.1	-1.2	-0.8	-1.1	-0.9	-1.4	-1.2	-1.3	-1.2
Unable to work because of sickness or disability	0.8	1.1	3.7	1.2	-1.2	-0.8	-0.7	-0.7	-0.5	-0.8	-1.2	-1.1	-0.6	-0.3	-1.3	-0.7	-1.0	-1.3	-1.9
Cholesterol lowering medication	0.8	1.2	2.0	-0.8	0.8	1.0	0.2	1.4	1.4	1.2	0.6	1.1	1.4	1.4	1.4	1.3	1.0	0.9	0.6
Schizophrenia vs Biploar Disorder	0.7	0.9	2.2	-1.1	1.1	0.6	1.5	0.7	0.8	1.0	0.0	1.3	0.8	0.6	0.8	0.8	1.1	1.0	1.1
Schizophrenia (2014)	0.7	1.6	3.1	1.6	-1.6	-0.5	-1.5	-1.2	-1.0	-0.7	-1.5	-1.4	-0.9	-1.1	-1.2	-1.2	-1.8	-1.6	-0.8
Respiratory disease	0.7	1.6	2.8	-1.6	1.7	1.1	0.4	1.2	1.1	0.6	1.3	1.2	1.0	1.1	1.1	1.4	1.5	1.6	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	4.3	1.2	-1.2	-1.5	-2.1	-1.4	-1.3	-0.8	-1.2	-1.0	-1.1	-1.4	-1.0	-1.4	-1.4	-1.3	-0.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	7.9	-1.2	1.2	1.6	2.8	1.6	1.0	2.1	2.0	2.1	0.9	1.1	1.2	1.2	1.2	1.1	1.1
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.1	1.2	-1.3	-1.0	-0.6	-0.8	-0.6	-0.1	-1.1	-1.0	-0.4	-0.8	-0.4	-1.0	-1.2	-1.5	-1.4
Heart disease (mother)	0.7	0.8	2.1	-1.3	1.4	1.2	-0.2	1.2	0.5	-0.1	0.6	0.2	0.8	0.1	0.6	0.5	0.9	1.4	1.2
Knee pain experienced in last month	0.7	1.0	2.7	0.8	-0.8	-1.3	-1.3	-0.7	-0.5	-1.6	-1.5	-1.5	-0.4	-0.5	-0.9	-0.7	-0.6	-1.0	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.9	-0.9	0.8	-0.1	1.6	0.6	0.4	-0.2	1.0	1.7	0.4	0.4	1.0	0.6	0.9	1.1	1.3
Basal cell carcinoma (self-reported)	0.7	0.9	3.3	-0.6	0.6	1.8	1.0	0.9	0.7	1.2	0.7	1.2	0.7	0.6	1.1	0.8	0.7	0.6	0.6
Impedance of whole body	0.7	3.5	7.8	-1.4	1.4	2.8	1.3	1.9	2.3	1.8	1.1	1.6	2.5	1.8	2.0	1.7	1.6	1.4	2.3
Schizophrenia (2018)	0.6	1.2	2.4	1.3	-1.4	-0.6	-1.2	-1.6	-1.1	-0.7	-1.0	-0.7	-1.0	-1.1	-0.9	-1.1	-1.4	-1.3	-0.2
Heel T-Score	0.6	4.7	7.0	-2.5	2.5	1.4	1.6	2.1	1.9	1.7	2.4	2.5	1.9	1.7	2.5	1.9	2.4	2.4	2.6
Angina	0.6	0.8	1.6	-1.2	1.2	0.5	0.8	0.8	0.7	0.7	1.1	0.5	0.5	0.8	0.2	1.0	1.2	1.3	0.4
Townsend deprivation index at recruitment	0.6	0.9	1.9	1.2	-1.3	-0.9	-0.1	-0.6	-0.5	-1.1	-1.4	-1.1	-0.4	-0.5	-0.2	-0.8	-1.1	-1.1	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.8	-1.1	1.1	0.8	-0.1	1.3	0.9	0.0	0.6	0.8	1.2	0.3	1.4	0.7	0.8	1.2	1.3
Mouth/teeth dental problems: Dentures	0.6	0.9	1.8	1.3	-1.3	-1.3	0.4	-0.9	-0.8	-0.7	-1.0	-0.1	-1.0	-0.6	-0.9	-0.9	-1.1	-1.4	-1.0
Age at first live birth	0.6	1.1	2.1	0.9	-1.0	-1.1	-0.2	-1.5	-1.3	-0.6	-0.5	-0.9	-1.3	-1.2	-1.4	-1.2	-1.2	-0.9	-1.0
Medication for pain relief, constipation, heartburn	0.6	1.0	2.7	-1.2	1.2	0.6	1.0	0.9	0.4	0.5	1.4	1.7	0.6	0.1	1.0	0.6	0.9	1.3	1.4
Osteoarthritis (self-reported)	0.6	0.8	2.4	0.8	-0.9	-1.2	-1.1	-0.6	-0.2	-0.9	-1.1	-1.5	-0.2	-0.1	-0.6	-0.2	-0.7	-0.9	-1.3
Blood Eosinophil Count	0.5	4.1	7.7	2.6	-2.7	-1.9	-2.4	-2.2	-1.4	-1.3	-2.5	-1.8	-1.7	-1.0	-1.6	-1.4	-2.1	-2.8	-1.9
Lung FEV1/FVC ratio	0.5	2.4	4.0	-1.9	1.8	1.7	1.5	1.8	1.2	0.7	1.6	1.9	1.3	1.0	2.0	1.1	1.6	1.8	1.5
Neuroticism	0.5	1.2	3.0	0.5	-0.6	-1.3	-1.7	-0.8	-1.4	-1.2	-0.9	-1.0	-1.1	-1.7	-0.8	-1.4	-0.9	-0.5	-0.3
Diabetes (father)	0.5	0.6	2.0	0.5	-0.5	-0.8	-1.0	-0.5	-0.4	-1.4	-1.1	-0.9	-0.3	-0.6	-0.2	-0.8	-0.6	-0.6	-0.7
Chronic bronchitis/emphysema (father)	0.5	0.5	1.0	0.8	-0.8	-0.7	-0.6	-0.9	-0.7	-1.0	-0.9	-0.6	-0.7	-0.6	-0.8	-0.7	-0.6	-0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.6	1.0	-1.0	-1.2	-1.6	-1.2	-1.2	-0.7	-0.9	-0.5	-1.2	-1.2	-1.0	-1.0	-1.1	-1.0	0.1
Illnesses of siblings	0.5	0.7	1.8	-1.2	1.2	0.8	1.4	0.9	0.5	0.1	1.1	-0.2	0.4	0.5	0.2	0.8	1.0	1.3	0.3
Falls in the last year	0.5	0.7	1.4	-0.8	0.7	0.9	0.8	0.8	0.9	1.2	0.8	0.8	0.9	0.7	0.8	0.7	0.8	0.6	0.8
Illnesses of mother	0.5	0.6	1.0	0.7	-0.8	-1.0	-0.4	-0.8	-0.8	-0.6	-0.6	-0.6	-0.7	-0.9	-0.9	-0.8	-0.8	-0.8	-0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.8	0.1	-0.2	1.2	1.4	0.9	0.8	1.1	0.3	0.0	0.7	0.9	-0.4	0.7	0.1	-0.3	-1.1
Medication: Seretide 50 evohaler	0.5	0.6	1.8	-0.6	0.6	0.4	0.6	0.8	0.9	1.4	0.8	0.9	0.9	0.7	0.8	0.7	0.7	0.4	0.5
Had major operations	0.5	0.6	0.9	-0.8	0.8	0.5	0.9	0.6	0.7	0.7	0.8	0.9	0.8	0.6	0.7	0.6	0.8	0.8	0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.0	1.0	-0.9	-0.8	-0.3	-0.7	-0.8	-0.2	-0.7	-0.6	-0.8	-0.9	-0.4	-0.9	-1.0	-0.8	-0.6
Supplements: Vitamin C	0.5	0.5	1.2	1.0	-1.0	-0.5	-0.3	-1.0	-0.5	-0.3	-0.7	-0.6	-0.8	-0.2	-0.8	-0.4	-0.6	-1.1	-0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.5	-0.8	0.8	0.8	0.3	0.5	0.4	1.0	0.9	1.1	0.6	0.1	0.8	0.4	0.7	0.8	1.6
Commuting to job workplace: Cycle	0.5	0.6	1.6	-0.7	0.7	1.0	0.7	0.7	0.8	0.0	0.5	0.8	1.2	0.2	1.3	0.3	0.6	0.6	0.7
Reaction Time	0.4	0.8	1.8	-0.8	0.8	1.2	-0.3	1.1	1.0	0.7	0.4	-0.1	1.3	0.4	1.1	0.8	0.6	1.0	1.3
Breast Cancer	0.4	0.9	3.5	-0.6	0.7	0.3	1.6	0.6	0.8	1.9	1.2	1.2	0.8	0.7	0.9	0.6	0.8	0.4	0.2
Blood White Count	0.4	3.1	12.1	1.9	-2.0	-1.8	-3.5	-1.8	-1.2	-1.2	-2.4	-1.3	-1.1	-1.1	-0.6	-1.3	-1.4	-2.0	-1.6
Smoking Status	0.4	1.0	6.1	-0.4	0.4	0.6	2.5	1.0	0.9	1.1	1.1	1.5	0.9	0.8	0.9	0.7	0.6	0.4	0.2
Serious illness, injury or assault to yourself	0.4	0.5	1.1	-0.9	0.9	0.4	-0.1	0.5	0.5	0.7	0.9	1.0	0.5	0.3	1.0	0.4	0.8	0.8	0.6
Mouth/teeth dental problems	0.4	0.6	2.3	-1.3	1.4	0.7	-0.2	0.5	0.2	0.0	1.1	0.1	0.3	0.1	0.2	0.6	1.1	1.5	0.8
Tense / ‘highly strung’	0.4	0.6	2.0	-1.0	0.9	0.3	0.5	0.8	0.1	0.8	1.4	1.2	0.1	0.1	0.6	0.2	0.7	0.9	1.2
Medication: Allopurinol	0.4	0.5	0.9	0.7	-0.7	-0.3	-0.8	-0.9	-0.8	0.2	-0.6	-0.9	-1.0	-0.5	-0.6	-0.6	-0.8	-0.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.7	1.0	-0.9	-0.9	0.5	-0.5	-0.4	-0.0	-0.5	-0.2	-0.7	0.1	-0.7	-0.3	-0.6	-1.0	-1.6
Guilty feelings	0.4	0.5	2.9	0.4	-0.4	-0.1	-1.1	-0.6	-0.9	-0.6	-0.4	0.0	-0.2	-1.7	-0.2	-1.1	-0.8	-0.3	0.7
Heart disease (siblings)	0.4	0.5	1.6	-0.5	0.6	0.2	0.3	0.5	0.9	1.3	0.6	0.5	0.7	1.0	0.4	0.9	0.8	0.6	0.3
Major Depression (MDD)	0.3	0.3	0.7	-0.2	0.2	0.8	0.1	0.4	0.8	0.8	0.4	0.5	0.8	0.8	0.6	0.7	0.5	0.3	0.4
Ovarian Cancer	0.3	0.5	1.4	-0.4	0.4	0.6	0.5	0.6	0.6	0.2	0.3	0.9	0.5	0.8	1.2	0.8	0.6	0.5	1.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.3	0.2	-0.2	-0.7	-1.1	-0.4	-0.7	-1.0	-0.7	-0.5	-0.6	-0.8	0.0	-0.6	-0.5	-0.3	-0.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.2	-0.5	0.5	-0.0	0.6	0.3	0.3	0.4	0.8	1.1	0.0	0.6	0.7	0.6	0.6	0.6	1.0
Pulse rate	0.3	0.6	1.6	-1.2	1.1	0.3	-1.0	0.5	0.0	-0.1	0.7	0.3	0.3	-0.4	0.6	0.3	0.9	1.3	1.1
Asthma	0.3	0.6	2.6	-0.8	0.8	1.1	0.2	0.8	0.4	0.5	0.7	0.8	0.5	0.3	0.5	0.7	0.5	0.8	1.6
Depression (self-reported)	0.3	0.4	0.8	0.5	-0.5	-0.3	-0.7	-0.5	-0.6	-0.8	-0.5	-0.3	-0.5	-0.8	-0.9	-0.7	-0.7	-0.5	0.4
Angina (self-reported)	0.3	0.4	1.1	-1.0	1.0	0.4	0.5	0.6	0.4	0.5	0.9	0.4	0.3	0.5	-0.0	0.7	0.9	1.1	0.3
Medication: Omeprazole	0.3	0.4	1.6	-0.2	0.2	0.0	0.9	-0.0	0.4	0.2	0.4	1.3	0.1	0.7	0.9	0.6	0.7	0.4	0.6
Age at last live birth	0.3	0.5	1.4	1.0	-1.0	0.2	-0.1	-0.8	-0.6	0.1	-0.9	-0.5	-0.5	-0.7	-0.3	-0.7	-1.2	-0.9	-0.3
Medication for cholesterol	0.3	0.5	1.0	0.5	-0.5	-0.7	-0.2	-0.9	-0.9	-0.9	-0.6	-0.7	-1.0	-0.7	-1.0	-0.6	-0.7	-0.4	-0.7
Asthma (self-reported)	0.3	0.5	2.3	-0.8	0.8	1.0	0.3	0.7	0.4	0.6	0.7	0.7	0.4	0.4	0.4	0.8	0.5	0.8	1.5
Hearing aid user	0.3	0.4	1.1	0.6	-0.7	-0.8	-0.7	-0.4	-0.4	-0.2	-0.8	-1.1	-0.6	-0.1	-0.9	-0.1	-0.4	-0.5	-0.7
Medication: Blood pressure	0.3	0.5	1.4	0.8	-0.8	-0.9	-0.4	-0.5	-0.4	-0.4	-0.6	-1.0	-0.4	-0.4	-0.8	-0.6	-0.6	-1.0	-1.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	0.3	-0.3	-0.7	-1.1	-0.8	-0.7	-0.8	-0.6	-0.8	-0.6	-0.7	-0.4	-0.7	-0.4	-0.3	-0.7
Number of operations (self-reported)	0.3	0.4	1.8	-0.0	0.0	-0.5	-1.1	-0.4	-0.8	-0.9	-0.3	0.3	-0.5	-1.3	-0.1	-0.7	-0.4	0.3	0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.6	-0.2	0.3	0.6	0.2	0.2	-0.6	0.1	0.5	0.5	-0.8	-0.3	0.2	0.1	0.1	0.4	0.8
LDL Cholesterol	0.2	0.3	1.3	0.0	0.9	0.7	0.1	0.7	0.3	0.0	0.0	-0.2	0.3	0.2	0.5	0.7	0.7	1.1	1.0
Triglycerides	0.2	0.3	1.0	0.0	-0.7	0.3	-0.3	-0.2	-0.3	-0.7	0.0	-1.0	-0.3	-0.3	-0.8	-0.2	-0.7	-0.6	-0.7
Waist Hip Ratio (WHR)	0.2	0.9	3.1	1.2	-1.2	-0.8	-0.5	-1.1	-0.5	-0.2	-1.2	-0.4	-0.5	-0.6	-0.6	-1.0	-1.0	-1.4	-1.8
Average weekly fortified wine intake	0.2	0.2	0.8	-0.1	0.1	0.9	-0.5	0.2	0.6	0.4	0.1	0.3	0.7	0.3	0.8	0.2	0.1	0.2	0.3
Taking other prescription medications	0.2	0.3	2.2	0.3	-0.3	-0.3	-1.5	-0.7	-0.4	-0.2	-0.4	-0.2	-0.6	-0.1	-0.9	-0.3	-0.0	-0.4	-0.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.9	0.1	-0.1	0.5	-0.9	0.2	0.7	0.6	-0.3	0.2	0.9	0.3	0.5	0.2	0.1	-0.1	0.3
High blood pressure (mother)	0.2	0.2	0.9	0.5	-0.5	0.0	-0.9	-0.1	0.1	-0.3	-0.9	-0.7	0.1	0.2	0.5	-0.2	-0.5	-0.7	-0.4
Number of incorrect matches in round	0.2	0.3	1.3	-0.1	0.1	0.3	0.2	0.1	0.5	0.7	0.5	1.1	0.7	0.2	0.9	0.2	0.0	0.2	0.9
Pain all over the body in last month	0.2	0.2	1.2	0.1	-0.1	-1.1	0.4	-0.2	-0.1	0.6	0.5	0.2	-0.2	-0.1	-0.4	-0.1	-0.1	-0.2	-0.6
Medication: Simvastatin	0.2	0.3	0.8	0.7	-0.7	-0.9	-0.7	-0.4	-0.3	0.1	-0.7	0.1	-0.3	-0.4	0.3	-0.7	-0.5	-0.9	-0.8
Medication: Cholesterol lowering	0.2	0.4	1.9	0.3	-0.2	-1.4	-0.7	-0.8	-0.7	-0.2	-0.2	-0.4	-0.7	-0.7	-0.2	-0.9	-0.1	-0.5	-0.2
Exposure to tobacco smoke at home	0.2	0.3	1.1	0.3	-0.3	0.2	-0.8	-0.1	-0.4	-0.7	-0.7	-1.1	-0.4	-0.4	-0.4	-0.5	-0.4	-0.4	-0.1
Blood clot in the leg (DVT)	0.2	0.3	1.2	-0.2	0.3	0.3	-0.3	0.3	0.3	-1.1	-0.3	0.6	0.1	0.6	1.1	0.6	0.3	0.4	0.9
High blood pressure (siblings)	0.2	0.2	0.9	0.5	-0.4	-0.2	-0.9	-0.3	0.0	0.1	-0.5	0.7	0.1	-0.1	0.8	-0.3	-0.4	-0.5	0.6
Forced vital capacity (FVC), Best measure	0.2	0.6	3.4	-0.0	0.1	0.3	1.9	0.5	0.3	1.6	1.0	1.0	0.2	0.5	-0.1	0.5	0.2	0.0	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	0.4	-0.3	0.5	0.0	-0.0	-0.3	-0.3	-0.6	-0.8	-0.2	-0.5	-0.2	-0.6	-0.6	-0.4	-0.8
Leg pain on walking	0.2	0.2	1.1	-0.2	0.1	-0.4	1.0	0.3	0.3	-0.2	0.0	-0.4	-0.1	0.9	-0.4	0.8	0.5	0.3	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.9	-0.9	0.9	0.0	0.7	0.3	-0.1	-0.2	0.8	0.2	0.0	-0.2	0.1	0.1	0.6	0.7	0.1
Commuting to job workplace: Walk	0.2	0.2	0.8	-0.0	-0.0	0.4	-0.5	0.1	0.7	0.2	-0.5	-0.8	0.5	0.9	0.1	0.8	0.2	0.1	0.4
Mineral and other dietary supplements	0.2	0.3	1.1	0.3	-0.3	-0.6	-0.3	-0.5	-0.3	-0.9	-0.6	-1.0	-0.6	0.1	-0.6	-0.1	-0.3	-0.3	-1.1
Illnesses of father: None of the above (group 1)	0.2	0.2	1.3	-0.0	0.0	0.6	0.3	0.3	0.4	1.1	0.5	0.8	0.6	0.0	0.1	0.1	0.0	-0.0	0.1
Wears glasses or contact lenses	0.2	0.2	0.7	0.1	-0.0	0.6	-0.3	0.4	0.6	-0.2	-0.5	-0.7	0.6	0.5	0.4	0.3	0.2	-0.1	-0.9
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.1	-0.1	0.2	0.6	-1.0	0.4	0.5	0.1	-0.2	0.7	0.8	0.0	1.0	0.0	0.0	-0.0	0.6
Irritability	0.2	0.4	1.3	-1.0	1.0	-0.1	1.1	0.6	-0.1	0.1	1.0	0.2	0.1	-0.3	0.4	0.0	0.7	0.9	0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.2	-0.1	0.2	0.3	-0.1	0.3	0.3	-1.0	-0.4	0.6	0.1	0.6	1.1	0.6	0.2	0.3	0.7
Prostate Cancer	0.1	0.1	0.3	0.3	-0.2	-0.1	-0.5	0.0	-0.2	-0.4	-0.4	0.3	-0.3	-0.0	0.4	-0.1	-0.2	0.0	-0.0
Lupus	0.1	0.2	1.3	0.1	-0.1	-0.9	-0.4	-0.5	0.1	-0.6	-0.1	0.4	-0.1	0.5	0.0	0.1	0.2	-0.4	-1.1
Systolic Blood Pressure	0.1	0.7	1.6	0.2	0.2	-0.7	-0.7	-0.9	-1.1	-1.1	-0.2	-1.0	-1.1	-1.1	-1.3	-0.9	-0.4	0.1	-0.8
Hair Pigment	0.1	1.9	3.3	-1.5	1.6	1.1	0.4	1.4	1.2	1.1	1.2	1.5	1.3	1.0	1.8	1.2	1.5	1.5	1.8
Tanning	0.1	0.9	2.8	-1.3	1.2	0.6	1.4	0.5	0.4	0.8	1.7	0.8	0.3	0.4	0.3	0.8	1.2	1.3	1.0
Average weekly spirits intake	0.1	0.1	0.5	-0.4	0.5	0.0	0.2	-0.2	0.1	-0.1	0.4	0.7	-0.0	0.2	0.5	0.3	0.5	0.5	0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.5	0.0	-0.0	-0.6	-0.6	-0.3	-0.3	-0.3	-0.1	0.3	-0.1	-0.7	0.2	-0.7	-0.2	-0.1	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	-0.3	0.3	-0.3	-0.5	-0.1	-0.1	-0.4	0.1	0.2	-0.2	-0.1	-0.4	-0.2	0.3	0.3	-0.3
Severe depression (siblings)	0.1	0.1	0.4	0.2	-0.2	0.1	-0.2	-0.2	0.4	0.5	0.1	0.3	0.2	0.7	0.2	0.3	0.0	-0.2	0.1
Maternal smoking around birth	0.1	0.1	0.8	-0.2	0.2	-0.7	-0.1	0.1	-0.3	-0.9	-0.1	0.3	-0.2	-0.4	0.2	-0.1	0.2	0.4	0.6
Supplements: Glucosamine	0.1	0.2	0.9	0.1	-0.1	-0.4	-1.0	-0.1	-0.4	-0.4	-0.2	-0.3	-0.0	-0.8	-0.3	-0.7	-0.4	-0.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.6	0.2	-0.1	-0.0	-0.3	-0.3	-0.3	-0.6	-0.5	-0.7	-0.3	-0.2	-0.3	-0.3	-0.2	-0.2	0.2
Medication: Atenolol	0.1	0.1	0.8	-0.3	0.3	-0.1	-0.9	0.1	0.1	-0.2	-0.1	-0.1	0.3	-0.2	0.3	-0.2	0.2	0.0	-0.3
Sitting height	0.1	0.4	2.2	0.4	-0.4	1.1	1.5	0.5	0.2	1.1	0.4	0.2	0.1	0.5	-0.4	0.3	-0.4	-0.4	-0.8
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	0.1	-0.0	0.2	-0.3	-0.1	-0.2	-0.7	-0.2	0.1	-0.0	-0.5	0.1	-0.3	-0.3	-0.1	0.2
Forced vital capacity (FVC)	0.1	0.5	3.3	-0.2	0.2	0.5	1.8	0.5	0.1	1.3	1.1	1.0	0.1	0.2	0.1	0.2	0.1	0.1	0.2
Financial difficulties in last 2 years	0.1	0.2	0.9	0.0	-0.1	0.4	0.8	0.4	0.5	0.3	0.2	0.1	0.2	0.9	-0.1	0.6	0.2	-0.2	-0.3
Time employed in main current job	0.1	0.2	0.7	-0.1	0.1	-0.2	-0.8	-0.4	-0.5	-0.3	0.0	-0.4	-0.3	-0.7	-0.4	-0.4	-0.2	0.2	0.1
Noisy workplace	0.1	0.1	0.6	0.2	-0.3	-0.8	0.4	-0.1	0.3	0.0	-0.1	0.3	0.0	0.7	0.2	0.2	0.3	-0.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.9	0.5	-0.5	0.2	-0.3	-0.2	0.2	-0.0	-0.9	-0.9	0.0	0.4	-0.2	0.3	-0.2	-0.3	0.4
Length of working week for main job	0.1	0.1	0.3	0.4	-0.5	0.4	-0.6	-0.2	-0.3	-0.1	-0.5	-0.2	-0.1	-0.5	-0.2	-0.3	-0.4	-0.5	-0.1
Peak expiratory flow (PEF)	0.1	0.2	0.8	0.7	-0.7	-0.1	0.4	-0.3	-0.5	-0.1	-0.4	0.3	-0.5	-0.4	-0.1	-0.5	-0.6	-0.9	-0.5
Loud music exposure frequency	0.1	0.1	0.6	0.3	-0.3	0.0	0.4	-0.1	0.1	0.8	0.2	0.2	-0.1	0.4	-0.0	0.2	0.0	-0.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.7	-0.4	0.5	0.3	0.1	0.2	-0.1	-0.1	0.6	0.8	-0.1	0.0	0.2	0.1	0.2	0.6	0.8
Medication: Ibuprofen	0.1	0.2	0.6	0.2	-0.2	0.4	-0.2	-0.1	0.5	0.1	-0.7	-0.7	0.3	0.7	-0.1	0.6	0.1	-0.1	0.2
Back pain experienced in last month	0.1	0.2	0.7	0.1	-0.1	0.2	0.8	0.5	0.6	0.3	-0.1	0.0	0.4	0.9	-0.1	0.5	0.3	-0.2	0.2
Breast cancer (self-reported)	0.1	0.1	0.5	0.3	-0.3	0.1	-0.7	-0.3	-0.5	-0.0	-0.3	0.1	-0.4	-0.7	-0.2	-0.5	-0.4	-0.2	-0.1
Financial situation satisfaction	0.1	0.1	0.6	-0.3	0.2	0.5	0.8	0.3	0.3	0.2	0.2	-0.1	0.1	0.5	0.5	0.4	0.3	0.2	-0.2
High cholesterol (Self-reported)	0.1	0.2	1.2	0.5	-0.5	-0.8	-1.1	-0.4	-0.3	-0.1	-0.5	0.1	-0.4	-0.2	0.3	-0.3	-0.2	-0.5	-0.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.4	0.4	0.4	0.1	0.5	0.4	0.1	0.2	-0.3	0.2	0.6	0.1	0.4	0.3	0.3	-0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.6	-0.0	0.0	-0.2	-0.1	-0.4	-0.3	0.2	0.4	0.8	-0.4	-0.2	-0.4	-0.2	0.1	0.0	0.3
Age started oral contraceptive pill	0.1	0.2	0.5	-0.4	0.4	0.0	-0.5	-0.0	0.3	0.5	0.3	0.5	0.5	0.1	0.7	0.1	0.4	0.4	0.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.9	0.1	-0.1	-0.0	0.7	-0.4	-0.0	0.0	0.1	0.9	-0.3	0.4	0.3	0.2	0.3	0.1	0.2
Age at First Birth	0.0	0.1	0.3	0.0	-0.2	0.6	-0.2	0.0	0.2	0.4	-0.3	0.2	0.2	0.3	0.1	0.2	-0.1	-0.2	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.3	-0.1	0.2	0.5	-0.2	0.4	0.1	-0.3	0.0	0.1	0.1	0.1	-0.0	0.0	0.0	0.2	-0.1
Illnesses of father: Heart disease	0.0	0.1	0.3	-0.4	0.4	-0.2	0.2	0.1	-0.1	-0.3	0.5	0.0	0.0	-0.2	-0.0	0.1	0.2	0.5	-0.1
Pain experienced in last month	0.0	0.0	0.2	-0.1	0.0	-0.0	0.3	0.0	-0.2	0.0	0.2	-0.2	-0.2	-0.1	-0.4	0.0	-0.0	0.2	-0.4

Hub : Genes

SH2B1

Models

Trait associations