Best TWAS P=5.95e-14 · Best GWAS P=4.36e-12 conditioned to 4.37e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TEKT3 | 0.18 | 0.21 | lasso | 1 | 0.20 | 2.1e-24 | -6.0 | 6.0 | 2.0e-09 | 0.02 | 0.43 | 0.57 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AC005517.3 | 0.11 | 0.07 | lasso | 6 | 0.06 | 6.2e-06 | -6.0 | 5.8 | 5.9e-09 | 0.05 | 0.64 | 0.33 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | AC005517.3 | 0.20 | 0.12 | lasso | 4 | 0.06 | 3.3e-04 | -6.0 | 5.9 | 3.0e-09 | 0.04 | 0.52 | 0.34 | FALSE |
| 4 | GTEx | Lung | AC005517.3 | 0.11 | 0.10 | lasso | 1 | 0.10 | 8.6e-08 | -6.0 | 6.0 | 2.0e-09 | 0.02 | 0.45 | 0.52 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | AC005517.3 | 0.16 | 0.12 | lasso | 5 | 0.13 | 9.4e-08 | -4.7 | 5.5 | 4.1e-08 | 0.04 | 0.78 | 0.18 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | AC005517.3 | 0.17 | 0.19 | lasso | 7 | 0.21 | 6.9e-17 | -6.0 | 5.6 | 2.3e-08 | 0.04 | 0.50 | 0.50 | FALSE |
| 7 | GTEx | Thyroid | AC005517.3 | 0.32 | 0.22 | lasso | 5 | 0.22 | 2.1e-16 | -6.0 | 6.0 | 1.8e-09 | 0.01 | 0.44 | 0.56 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | TEKT3 | 0.15 | 0.03 | bslmm | 496 | 0.06 | 2.3e-08 | -6.0 | 7.5 | 5.9e-14 | 0.15 | 0.59 | 0.40 | TRUE |
| 9 | YFS | Blood | CDRT4 | 0.20 | 0.20 | enet | 32 | 0.22 | 6.3e-71 | -5.5 | 6.5 | 5.7e-11 | 0.10 | 0.94 | 0.06 | FALSE |