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chr17:16,419,425-18,325,085

Best TWAS P=5.07e-13 · Best GWAS P=4.15e-12 conditioned to 0.826

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	COPS3	0.06	0.04	lasso	2	0.03	2.4e-04	-6.8	-6.8	8.1e-12	0.99	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NT5M	0.13	0.10	enet	14	0.10	1.4e-12	-4.1	-5.4	5.3e-08	0.63	0.96	0.04	FALSE
3	GTEx	Adipose Subcutaneous	FLCN	0.33	0.31	lasso	5	0.31	7.7e-26	-6.9	6.9	4.8e-12	-0.87	0.01	0.99	FALSE
4	GTEx	Adipose Subcutaneous	TOM1L2	0.04	0.04	lasso	3	0.04	5.3e-04	5.3	-5.2	2.1e-07	0.11	0.75	0.10	FALSE
5	GTEx	Adipose Visceral Omentum	FLCN	0.26	0.30	enet	28	0.24	6.6e-13	-6.9	6.8	9.3e-12	-0.88	0.01	0.99	FALSE
6	GTEx	Adipose Visceral Omentum	TOM1L2	0.15	0.13	lasso	4	0.11	3.6e-06	5.2	-5.1	2.8e-07	0.10	0.79	0.20	FALSE
7	GTEx	Adrenal Gland	SREBF1	0.17	0.11	lasso	4	0.09	3.5e-04	5.1	5.2	2.6e-07	-0.10	0.13	0.30	FALSE
8	GTEx	Adrenal Gland	FLCN	0.22	0.13	lasso	2	0.07	2.0e-03	-6.9	6.9	5.5e-12	-0.86	0.01	0.97	FALSE
9	GTEx	Artery Aorta	FLCN	0.53	0.50	enet	53	0.54	8.8e-35	-6.9	5.6	2.2e-08	-0.78	0.01	0.99	FALSE
10	GTEx	Artery Aorta	AC122129.1	0.06	0.01	lasso	5	0.00	3.6e-01	5.2	-5.3	1.4e-07	0.11	0.19	0.31	FALSE
11	GTEx	Artery Coronary	FLCN	0.39	0.46	enet	8	0.42	2.7e-15	-6.9	7.0	3.3e-12	-0.88	0.01	0.99	FALSE
12	GTEx	Artery Tibial	FLCN	0.51	0.57	enet	14	0.53	2.1e-48	-6.9	6.9	6.8e-12	-0.87	0.01	0.99	FALSE
13	GTEx	Brain Caudate basal ganglia	FLCN	0.20	0.27	lasso	4	0.19	3.9e-06	-6.9	7.0	2.9e-12	-0.85	0.01	0.98	FALSE
14	GTEx	Brain Cerebellar Hemisphere	FLCN	0.32	0.26	enet	8	0.25	4.1e-07	-6.7	6.9	4.7e-12	-0.86	0.01	0.98	FALSE
15	GTEx	Brain Cerebellum	TOM1L2	0.10	0.06	lasso	5	0.02	6.6e-02	5.4	-5.5	3.9e-08	0.11	0.15	0.38	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	FLCN	0.18	0.19	lasso	2	0.02	8.3e-02	-6.9	6.7	2.2e-11	-0.87	0.01	0.98	FALSE
17	GTEx	Breast Mammary Tissue	DRG2	0.33	0.13	enet	29	0.17	6.1e-09	3.0	-5.5	3.6e-08	0.13	0.47	0.47	FALSE
18	GTEx	Breast Mammary Tissue	FLCN	0.38	0.46	enet	18	0.43	5.8e-24	-6.9	7.2	7.8e-13	-0.84	0.01	0.99	FALSE
19	GTEx	Breast Mammary Tissue (Female)	FLCN	0.34	0.36	lasso	5	0.34	8.0e-11	-6.9	7.0	2.0e-12	-0.89	0.01	0.99	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	FLCN	0.33	0.17	enet	35	0.16	5.8e-06	-6.8	5.3	9.3e-08	-0.76	0.01	0.98	FALSE
21	GTEx	Cells Transformed fibroblasts	FLCN	0.35	0.28	enet	11	0.29	6.4e-22	-6.9	6.7	2.7e-11	-0.85	0.01	0.99	FALSE
22	GTEx	Cells Transformed fibroblasts	TOM1L2	0.05	0.00	enet	14	0.00	2.8e-01	3.0	-5.8	5.3e-09	0.10	0.04	0.82	FALSE
23	GTEx	Colon Sigmoid	FLCN	0.45	0.47	enet	17	0.47	1.3e-18	-6.9	7.2	7.6e-13	-0.88	0.01	0.99	FALSE
24	GTEx	Colon Transverse	FLCN	0.29	0.35	lasso	3	0.34	4.1e-17	-6.9	6.8	7.2e-12	-0.85	0.01	0.99	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	FLCN	0.43	0.45	enet	11	0.44	1.1e-17	-6.9	6.8	1.0e-11	-0.85	0.01	0.99	FALSE
26	GTEx	Esophagus Mucosa	FLCN	0.39	0.42	enet	14	0.41	1.3e-29	-6.9	6.7	2.6e-11	-0.85	0.01	0.99	FALSE
27	GTEx	Esophagus Muscularis	FLCN	0.50	0.58	enet	10	0.57	4.6e-42	-6.9	7.1	1.0e-12	-0.88	0.01	0.99	FALSE
28	GTEx	Heart Atrial Appendage	FLCN	0.39	0.47	enet	11	0.48	2.4e-24	-6.7	7.2	6.5e-13	-0.88	0.01	0.99	FALSE
29	GTEx	Heart Left Ventricle	FLCN	0.46	0.48	lasso	7	0.48	1.6e-28	-6.9	6.8	1.1e-11	-0.85	0.01	0.99	FALSE
30	GTEx	Liver	FLCN	0.20	0.01	enet	14	0.00	3.1e-01	-6.8	6.2	7.5e-10	-0.80	0.02	0.86	FALSE
31	GTEx	Lung	FLCN	0.39	0.44	enet	6	0.42	1.5e-34	-6.9	6.9	4.0e-12	-0.87	0.01	0.99	FALSE
32	GTEx	Muscle Skeletal	FLCN	0.10	0.08	lasso	3	0.06	7.3e-07	-6.9	6.6	4.4e-11	-0.83	0.01	0.99	FALSE
33	GTEx	Muscle Skeletal	TOM1L2	0.08	0.11	lasso	6	0.10	5.3e-10	5.3	-5.3	1.4e-07	0.09	0.83	0.17	FALSE
34	GTEx	Nerve Tibial	FLCN	0.43	0.43	enet	32	0.45	6.7e-35	-6.9	7.0	2.8e-12	-0.87	0.01	0.99	FALSE
35	GTEx	Ovary	FLCN	0.22	0.21	enet	4	0.12	9.3e-04	-6.9	6.9	4.3e-12	-0.86	0.01	0.96	FALSE
36	GTEx	Pancreas	FLCN	0.15	0.15	lasso	2	0.12	8.5e-06	-6.9	6.9	3.8e-12	-0.86	0.01	0.99	FALSE
37	GTEx	Prostate	FLCN	0.32	0.40	enet	6	0.27	2.2e-07	-6.8	6.9	5.6e-12	-0.87	0.01	0.99	FALSE
38	GTEx	Skin Not Sun Exposed Suprapubic	FLCN	0.17	0.16	lasso	3	0.15	1.2e-08	-6.9	7.2	5.7e-13	-0.94	0.01	0.99	FALSE
39	GTEx	Skin Sun Exposed Lower leg	DRG2	0.06	0.07	lasso	4	0.08	6.5e-07	5.1	-5.5	4.1e-08	0.10	0.45	0.53	FALSE
40	GTEx	Skin Sun Exposed Lower leg	FLCN	0.23	0.18	lasso	6	0.18	6.0e-15	-6.7	6.7	1.6e-11	-0.85	0.01	0.99	FALSE
41	GTEx	Small Intestine Terminal Ileum	FLCN	0.29	0.20	enet	6	0.11	1.9e-03	6.7	7.1	9.1e-13	-0.94	0.01	0.92	FALSE
42	GTEx	Spleen	FLCN	0.57	0.38	lasso	4	0.39	6.0e-11	-6.7	6.5	1.0e-10	-0.84	0.01	0.99	FALSE
43	GTEx	Stomach	FLCN	0.35	0.38	lasso	2	0.38	2.2e-19	-6.9	6.9	5.8e-12	-0.86	0.01	0.99	FALSE
44	GTEx	Testis	FLCN	0.47	0.41	enet	38	0.38	9.8e-18	-6.9	5.7	1.5e-08	-0.76	0.01	0.99	FALSE
45	GTEx	Thyroid	FLCN	0.31	0.34	enet	9	0.30	1.1e-23	-6.9	6.9	4.7e-12	-0.89	0.01	0.99	FALSE
46	GTEx	Uterus	FLCN	0.53	0.37	lasso	4	0.43	6.1e-10	-6.7	6.4	1.5e-10	-0.81	0.01	0.98	FALSE
47	GTEx	Vagina	FLCN	0.21	0.22	enet	9	0.22	9.8e-06	-6.9	7.2	5.1e-13	-0.86	0.01	0.97	TRUE
48	GTEx	Whole Blood	SREBF1	0.04	0.06	lasso	5	0.05	2.4e-05	5.2	-5.3	1.1e-07	0.10	0.84	0.14	FALSE
49	GTEx	Whole Blood	COPS3	0.14	0.17	lasso	6	0.16	1.3e-14	6.7	6.7	1.8e-11	-0.96	0.02	0.98	FALSE
50	METSIM	Adipose	FLCN	0.36	0.34	lasso	6	0.33	2.1e-50	-6.9	6.8	8.5e-12	-0.84	0.01	0.99	FALSE
51	NTR	Blood	COPS3	0.03	0.03	lasso	5	0.02	1.4e-08	-6.9	6.8	8.1e-12	-1.00	0.01	0.99	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	FLCN	0.21	0.12	lasso	10	0.16	1.8e-19	-4.1	5.3	8.8e-08	-0.64	0.99	0.01	FALSE
53	YFS	Blood	COPS3	0.17	0.22	lasso	3	0.22	8.3e-69	-6.7	6.7	1.9e-11	-0.98	0.01	0.99	FALSE
54	YFS	Blood	SREBF1	0.07	0.11	lasso	7	0.11	2.2e-33	5.1	-5.2	1.8e-07	0.09	0.84	0.16	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLCN	0.04	0.04	lasso	2	0.04	1.9e-04	-6.1	6.3	2.8e-10	-0.78	0.02	0.92	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLCN	0.02	0.02	blup	49	0.02	2.4e-05	-6.1	6.7	2.0e-11	-0.87	0.04	0.96	FALSE
57	The Cancer Genome Atlas	Colon Adenocarcinoma	FLCN	0.06	0.07	lasso	3	0.07	8.3e-05	-6.7	6.8	7.8e-12	-0.88	0.01	0.98	FALSE
58	The Cancer Genome Atlas	Glioblastoma Multiforme	FLCN	0.15	0.15	lasso	2	0.13	1.0e-04	-6.9	6.7	1.5e-11	-0.97	0.01	0.93	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLCN	0.03	0.04	enet	8	0.02	3.9e-03	-6.9	6.8	1.4e-11	-0.98	0.01	0.98	FALSE
60	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLCN	0.10	0.04	enet	4	0.06	2.5e-04	-4.1	6.1	8.8e-10	-0.74	0.03	0.46	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLCN	0.03	0.03	lasso	4	0.02	6.7e-04	-6.9	6.7	2.0e-11	-0.78	0.01	0.96	FALSE
62	The Cancer Genome Atlas	Lung Adenocarcinoma	FLCN	0.03	0.02	enet	5	0.02	6.7e-04	-6.7	6.8	8.3e-12	-0.86	0.02	0.97	FALSE
63	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLCN	0.04	0.03	blup	49	0.03	4.3e-04	-6.9	6.9	3.9e-12	-0.90	0.01	0.99	FALSE
64	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FLCN	0.09	0.10	enet	8	0.08	3.5e-04	-6.7	7.1	1.1e-12	-0.96	0.01	0.97	FALSE
65	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLCN	0.15	0.11	lasso	4	0.16	5.1e-07	-6.8	6.8	1.1e-11	-0.84	0.01	0.99	FALSE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLCN	0.05	0.02	enet	6	0.05	9.6e-06	-4.9	6.7	1.9e-11	-0.87	0.02	0.98	FALSE
67	The Cancer Genome Atlas	Soft Tissue Sarcoma	PLD6	0.19	0.01	enet	8	0.04	2.2e-03	-5.7	-5.1	2.7e-07	0.55	0.02	0.25	FALSE
68	The Cancer Genome Atlas	Skin Cutaneous Melanoma	FLCN	0.21	0.07	lasso	2	0.10	1.5e-03	-6.8	7.0	2.7e-12	-0.86	0.01	0.69	FALSE
69	The Cancer Genome Atlas	Stomach Adenocarcinoma	SREBF1	0.04	0.03	blup	32	0.02	7.8e-03	6.4	6.0	1.8e-09	-0.11	0.01	0.90	TRUE
70	The Cancer Genome Atlas	Thyroid Carcinoma	MPRIP	0.05	0.01	enet	11	0.04	4.3e-05	-3.3	5.6	2.7e-08	-0.50	0.63	0.08	FALSE