Best TWAS P=5.15e-12 · Best GWAS P=2.81e-07 conditioned to 0.137
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | ACTN2 | 0.25 | 0.08 | enet | 23 | 0.14 | 4.4e-09 | -4.3 | 5.9 | 3.2e-09 | -0.75 | 0.01 | 0.98 | FALSE |
| 2 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ACTN2 | 0.05 | 0.02 | blup | 115 | 0.03 | 3.3e-04 | -2.7 | 5.3 | 1.1e-07 | -0.53 | 0.03 | 0.05 | FALSE |
| 3 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ACTN2 | 0.14 | 0.08 | blup | 115 | 0.09 | 1.5e-09 | -4.2 | 6.9 | 5.1e-12 | -0.57 | 0.09 | 0.81 | TRUE |