TWAS hub - ACTN2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0960	0.0360	4.1e-03	0.004	0.007	0.008	0.006	0.005	9.1e-02	3.7e-02	3.0e-02	0.06	6.5e-02
2	GTEx	Esophagus Muscularis	0.2550	0.0650	1.0e-04	0.082	NA	0.144	NA	0.063	1.0e-05	NA	4.4e-09	NA	1.1e-04
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0528	0.0257	2.8e-03	0.015	0.028	0.010	NA	0.019	6.8e-03	3.3e-04	2.4e-02	NA	2.8e-03
4	TCGA	Brain Lower Grade Glioma	0.0463	0.0202	2.4e-03	0.022	0.020	0.008	NA	0.010	1.3e-03	2.0e-03	3.6e-02	NA	2.1e-02
5	TCGA	Prostate Adenocarcinoma	0.1360	0.0394	4.3e-10	0.078	0.089	0.078	NA	0.078	1.4e-08	1.5e-09	1.6e-08	NA	1.5e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Pulse rate, automated reading	7.4	23.8	47.6	1.6	5.9	5.3	2.4	6.9
Pulse rate	4.9	8.2	12.4	2.0	3.4	3.0	1.9	3.5
Smoking Status	4.2	10.0	17.6	2.5	4.2	3.5	-0.1	3.8
Pain all over the body in last month	3.8	4.1	8.9	0.6	2.7	3.0	0.4	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	3.4	4.5	6.8	1.9	2.6	2.2	-1.5	2.3
Loneliness, isolation	3.4	4.6	9.2	1.5	1.8	2.9	0.4	3.0
Illnesses of father: Heart disease	3.3	4.6	7.8	1.3	2.5	2.8	1.5	2.4
Gout (self-reported)	3.1	4.3	8.8	-0.7	-1.9	-1.9	-2.2	-3.0
Pulse wave peak to peak time	3.1	3.6	8.2	-0.9	-2.9	-1.4	-0.9	-2.5
Pulse wave Arterial Stiffness index	3.0	3.5	7.5	0.9	2.7	1.5	1.0	2.5
Medication for pain relief, constipation, heartburn	3.0	5.2	8.7	-0.4	-2.8	-3.0	-1.1	-2.8
Worry (Nagel 2018)	2.9	6.1	10.7	-0.7	-2.7	-3.0	-1.7	-3.3
Current tobacco smoking	2.8	4.5	8.3	1.1	2.9	2.7	-1.0	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.3	6.1	0.3	2.5	2.3	1.2	1.9
Medication: Lansoprazole	2.7	3.1	5.3	1.8	2.3	1.9	0.5	1.8
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.1	11.9	1.2	0.3	1.4	3.5	-0.3
Smoking status: Current	2.7	4.2	7.5	0.8	2.7	2.7	-0.9	2.2
Fluid intelligence score	2.5	5.2	7.1	2.4	1.9	2.7	2.2	2.2
Overall health rating	2.5	5.5	11.1	1.9	3.3	2.4	-1.7	1.9
Serious illness, injury or assault to yourself	2.3	2.8	5.2	-0.7	-1.2	-2.3	-2.0	-1.7
Mouth/teeth dental problems: Loose teeth	2.3	2.7	5.4	1.7	2.3	1.6	0.1	1.6
Breast cancer (self-reported)	2.2	2.7	6.6	0.5	-2.6	-1.9	-0.8	-1.6
Pain experienced in last month	2.2	3.7	7.0	-0.6	-2.6	-2.1	-2.1	-1.6
Frequency of depressed mood in last 2 weeks	2.1	3.0	6.2	0.5	2.5	1.4	-1.9	1.7
Loud music exposure frequency	2.1	2.3	3.3	1.4	1.7	1.8	-1.2	1.4
Age started oral contraceptive pill	2.1	2.6	5.2	-1.0	1.5	1.7	1.2	2.3
Exposure to tobacco smoke at home	2.0	2.2	4.2	0.9	1.7	0.8	-1.5	2.0
Eye problems/disorders: Cataract	2.0	2.3	4.7	-0.3	-2.2	-2.0	-0.7	-1.4
Townsend deprivation index at recruitment	1.9	2.7	6.4	-1.5	1.4	1.4	-0.8	2.5
Supplements: Glucosamine	1.9	2.5	3.4	-0.9	-1.8	-1.8	1.7	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	7.2	0.5	2.7	1.4	-0.3	1.4
Pack years adult smoking proportion	1.8	2.8	5.4	1.5	2.3	1.3	-1.6	1.4
Qualifications: CSEs or equivalent	1.8	2.4	5.3	0.0	-1.2	-1.7	-1.5	-2.3
Worrier / anxious feelings	1.8	3.4	7.4	-0.5	-2.4	-1.8	-0.8	-2.7
Number of full brothers	1.8	2.3	3.7	1.7	1.9	1.8	0.1	1.1
Chest pain or discomfort	1.8	2.5	5.3	0.1	2.3	1.9	0.1	1.9
Medication for hormone replacement therapy	1.7	1.9	4.4	2.1	1.0	1.9	0.2	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	7.1	0.4	2.7	1.9	-0.8	1.4
Lung cancer (father)	1.7	1.9	3.1	-1.1	-1.8	-1.3	-1.0	-1.7
Medication: Paracetamol	1.7	2.8	5.0	0.8	2.2	1.9	0.9	2.0
Had major operations	1.7	2.0	5.8	-1.1	2.4	0.8	0.2	1.5
Mineral and other dietary supplements	1.7	2.3	6.7	0.6	2.1	0.4	-2.6	0.1
Wheeze or whistling in the chest in last year	1.6	2.9	6.1	-0.6	2.5	1.7	-2.0	0.9
Health satisfaction	1.6	2.0	4.9	-0.3	2.2	0.8	-1.7	1.3
Osteoarthritis (self-reported)	1.6	2.1	3.2	0.8	1.5	1.7	1.8	1.2
Medication: Paracetamol	1.6	2.5	4.5	1.0	2.1	1.9	0.6	1.8
Pack years of smoking	1.6	2.3	4.7	1.3	2.2	1.2	-1.4	1.3
Number of treatments/medications taken	1.5	2.8	4.7	-0.4	2.2	2.1	0.7	2.0
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	3.6	1.9	1.6	1.9	-1.1	1.0
Illnesses of siblings	1.5	2.1	4.3	1.6	-2.1	-1.3	-0.5	-1.3
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.8	0.7	1.2	1.0	1.5	2.0
Supplements: Fish oil (including cod liver oil)	1.5	1.9	6.6	0.4	-1.1	1.0	2.6	0.9
Unable to work because of sickness or disability	1.5	1.9	5.6	0.0	2.4	0.9	-0.9	1.6
Coronary Artery Disease (CAD)	1.4	1.7	3.9	1.3	-1.5	-0.7	0.2	-2.0
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	2.8	-1.4	-0.7	-1.7	-1.2	-1.2
Alcohol usually taken with meals	1.4	2.2	6.9	-1.3	-1.4	-0.7	2.6	0.2
Neck or shoulder pain in last month	1.4	2.0	5.6	0.3	1.7	2.4	-0.1	1.2
Medication: Allopurinol	1.4	1.9	3.9	-0.4	-1.3	-0.9	-2.0	-1.7
Ever smoked	1.4	2.5	4.4	2.1	2.1	1.6	-0.4	1.1
Heart disease (siblings)	1.4	1.8	3.1	-0.4	1.3	1.8	1.6	1.2
Depression (Nagel 2018)	1.3	1.9	5.6	0.5	1.6	0.8	-2.4	0.7
Sensitivity / hurt feelings	1.3	2.3	4.7	-0.8	-0.9	-1.4	-1.8	-2.2
Multivitamins +/- minerals	1.3	1.6	4.4	1.4	-0.0	1.1	2.1	0.8
Medication: Atenolol	1.3	1.7	3.2	-0.3	1.2	1.8	0.8	1.7
Financial difficulties in last 2 years	1.3	1.7	3.6	-0.2	1.8	1.9	-1.0	0.9
Noisy workplace	1.3	1.6	4.0	2.0	1.2	1.6	0.3	0.3
Medication: Bendroflumethiazide	1.3	1.9	6.2	-0.4	2.5	0.8	-0.3	1.6
Risk taking	1.3	2.0	5.9	0.4	2.4	1.4	-0.9	1.1
Alcohol drinker status: Previous	1.3	1.5	6.3	-2.5	0.3	0.6	-0.0	0.8
Lupus	1.2	1.8	3.1	-1.8	1.4	1.4	0.6	1.3
Father’s age at death	1.2	1.6	4.0	-0.9	-2.0	-1.1	1.3	-0.6
Length of working week for main job	1.2	1.3	2.0	1.1	1.4	1.3	0.0	1.2
Leg pain on walking	1.2	1.5	3.3	-1.6	1.8	0.7	0.0	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.6	-0.2	1.9	0.8	0.6	1.5
Ever depressed for a whole week	1.2	1.5	2.7	0.4	1.5	1.6	0.5	1.5
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	4.5	-1.1	-0.4	0.7	-2.1	0.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	1.7	-0.4	0.8	1.2	1.2	1.3
Nervous feelings	1.1	2.1	4.6	0.3	-1.2	-2.2	-0.9	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	4.9	-0.5	-2.2	-1.9	0.3	-1.8
Heart attack	1.1	1.4	2.5	-0.5	1.5	1.4	-0.1	1.6
Alcohol intake versus 10 years previously	1.1	1.6	2.5	0.9	1.6	1.2	-1.5	1.1
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.1	-0.7	1.4	1.4	0.3	1.4
Shortness of breath walking on level ground	1.1	1.4	2.8	-1.7	1.1	1.0	-0.7	1.2
Medication: Blood pressure	1.1	1.9	4.3	-0.3	0.9	2.0	0.5	2.1
Knee pain experienced in last month	1.1	1.7	5.8	-0.3	2.4	1.1	-0.1	1.2
Average weekly red wine intake	1.1	1.7	5.4	-1.4	-0.5	-0.9	2.3	-0.2
Commuting to job workplace: Public transport	1.1	1.3	4.0	0.4	0.9	2.0	0.8	0.9
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.7	-0.6	1.3	1.6	0.0	1.5
Ulcerative Colitis	1.0	1.4	3.5	0.7	1.4	1.9	-0.5	0.9
Vitamin and mineral supplements	1.0	1.3	4.3	-1.3	-0.2	-0.7	-2.1	-0.3
Supplements: Zinc	1.0	1.1	2.5	-1.6	-0.7	0.7	1.2	0.8
Taking other prescription medications	1.0	1.6	3.7	-1.3	1.4	1.9	-0.4	0.6
High blood pressure (mother)	1.0	1.4	2.5	0.7	0.5	1.4	1.3	1.6
Had other major operations	1.0	1.3	3.2	1.8	1.5	0.2	-0.1	0.9
Illnesses of mother	1.0	1.3	3.0	-0.1	-1.6	-0.7	-0.8	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.0	0.7	1.4	1.3	0.4	1.4
Number of children fathered	1.0	1.1	2.0	-1.0	1.3	1.4	0.0	1.0
Number of full sisters	1.0	1.2	2.3	-1.3	1.0	-0.4	-1.5	-0.9
Ever had bowel cancer screening	1.0	1.2	2.6	-0.6	0.8	1.6	0.9	1.3
Medication: Gliclazide	1.0	1.1	4.1	-0.1	-1.0	-0.4	-0.4	-2.0
Mother’s age at death	1.0	1.2	2.4	1.0	-1.1	-1.5	0.2	-1.2
Supplements: Calcium	1.0	1.1	4.9	-0.3	-0.4	0.6	2.2	0.0
Intelligence (Savage-Jansen 2018)	0.9	2.7	4.3	0.6	1.5	1.8	2.1	1.7
Neuroticism (Nagel 2018)	0.9	2.0	3.6	-0.4	-1.2	-1.4	-1.8	-1.9
Ulcerative Colitis (UC)	0.9	1.7	2.8	0.6	1.7	1.7	1.0	1.2
Verbal and Numeric Reasoning (VNR)	0.9	2.2	3.5	1.3	1.3	1.9	1.3	1.5
Bipolar Disorder (2011)	0.9	0.9	2.0	-0.7	-1.4	0.1	0.2	-1.4
HbA1C	0.9	1.0	1.9	-0.5	1.1	0.5	-1.2	1.4
Hearing difficulty/problems: Yes	0.9	1.4	2.0	-1.1	1.0	1.4	1.2	1.2
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	9.1	0.6	-3.0	-1.8	-0.3	-1.7
Peak expiratory flow (PEF)	0.9	2.1	6.4	0.5	-2.5	-0.4	0.5	-1.9
Pulse wave reflection index	0.9	1.1	2.6	0.6	1.6	0.4	0.1	1.6
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.9	0.6	-1.3	-0.7	-0.5	-1.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.1	1.1	-0.5	-1.8	-0.4	-1.7
Medication: Amlodipine	0.9	1.3	2.1	-0.1	1.0	1.4	1.3	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.1	-1.2	0.7	-0.4	-1.8	-0.4
Hypertension (Self-reported)	0.9	2.4	4.2	0.0	2.1	1.2	1.5	2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.2	0.8	0.8	1.2	0.4	1.5
Osteoporosis (self-reported)	0.9	1.1	2.3	-0.5	0.8	1.3	1.5	0.8
Illnesses of father: None of the above (group 1)	0.9	1.1	1.7	-0.8	-1.3	-0.9	-1.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	4.4	-0.8	-2.1	-1.3	0.4	-1.6
Financial situation satisfaction	0.9	1.1	2.6	-1.6	0.4	0.3	-1.4	-0.8
Medication: Blood pressure	0.9	1.7	3.1	-0.6	1.8	1.1	1.5	1.2
Medication: Lisinopril	0.9	1.1	3.4	-1.9	-0.6	1.0	1.0	-0.1
Irritability	0.9	1.5	3.7	-0.9	0.0	-1.1	-1.9	-1.3
Vascular/heart problems diagnosed by doctor	0.9	2.6	5.8	0.1	-2.1	-1.3	-1.1	-2.4
Ever had hysterectomy (womb removed)	0.8	0.9	3.1	0.0	-0.8	0.5	-1.8	-0.6
Fed-up feelings	0.8	1.4	2.3	1.4	1.1	1.5	-1.2	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.1	-0.6	-1.8	-1.6	0.9	-1.5
High blood pressure	0.8	2.1	4.3	-0.1	2.0	1.1	1.1	2.1
Chronic bronchitis/emphysema (father)	0.8	1.0	3.3	-1.8	0.5	0.0	-1.2	-0.2
Qualifications: None of the above	0.8	1.7	3.3	-0.8	1.8	1.1	-0.3	1.8
Birth weight	0.8	1.6	6.5	-0.2	0.5	2.5	0.5	1.1
High blood pressure (siblings)	0.8	1.2	2.3	-1.5	0.8	1.3	0.5	1.0
Emphysema/chronic bronchitis	0.8	0.9	2.3	-0.8	-0.4	-0.7	-1.5	-0.8
Long-standing illness, disability or infirmity	0.8	1.3	2.7	0.3	1.4	1.6	-0.6	1.1
Medication for cholesterol	0.8	1.2	2.2	0.7	-1.1	-1.5	-1.1	-0.8
Hearing aid user	0.8	0.9	2.2	-0.2	-1.1	-0.3	-0.9	-1.5
Ever had prostate specific antigen (PSA) test	0.8	1.0	2.2	-0.7	0.8	1.5	0.5	1.1
Systolic Blood Pressure	0.7	3.6	7.6	-2.1	-1.2	-2.8	-0.1	-2.1
Average weekly fortified wine intake	0.7	0.8	3.3	0.0	1.8	0.1	-0.5	0.7
Past tobacco smoking	0.7	1.3	3.3	-1.0	-1.8	-0.8	1.0	-0.6
Hearing difficulty/problems with background noise	0.7	1.1	2.5	-0.6	1.4	0.8	-0.3	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.3	-0.3	1.8	0.8	-0.5	1.0
Headache pain in last month	0.7	1.1	3.6	0.6	0.4	1.1	1.9	0.5
Exposure to tobacco smoke outside home	0.7	0.9	3.7	1.9	0.7	0.1	-0.5	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.7	-1.1	-0.7	1.3	0.7	0.4
Smoking status: Previous	0.7	1.0	2.6	1.2	1.6	0.8	0.0	0.8
Diabetes diagnosed by doctor	0.7	1.1	2.5	1.5	0.8	1.6	-0.0	0.3
Wears glasses or contact lenses	0.7	0.8	2.7	1.6	0.4	-0.7	-0.6	-0.5
Cholesterol lowering medication	0.7	1.1	4.7	-2.2	0.1	0.7	0.4	0.4
Bipolar Disorder (2018)	0.6	0.9	2.4	1.2	-1.5	0.3	-0.8	-0.5
Alzheimer’s Disease (in mother)	0.6	0.8	1.5	-0.8	-1.1	-0.5	1.2	-0.4
Irritable Bowel Disease (IBD)	0.6	1.5	2.6	1.2	1.4	1.6	1.1	0.3
Reaction Time	0.6	1.1	2.2	-0.7	-0.8	-1.3	0.5	-1.5
Body Mass Index (BMI) (2010)	0.6	0.8	1.9	0.6	-1.0	-0.2	-0.7	-1.4
Crohns Disease (2012)	0.6	0.9	2.5	1.6	0.6	0.9	0.9	-0.2
Neuroticism	0.6	1.5	4.7	-0.6	-1.1	-0.4	-2.2	-1.0
Hair/balding pattern: Pattern 2	0.6	0.7	1.7	0.3	0.5	0.7	1.0	1.3
Medication: Ramipril	0.6	0.8	1.7	-0.2	0.8	1.2	-0.0	1.3
Falls in the last year	0.6	0.9	2.9	0.6	0.6	1.7	0.1	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.3	0.5	1.1	1.0	0.9	0.5
Blood clot in the leg (DVT)	0.6	0.8	3.3	1.8	-0.7	0.5	-0.1	-0.2
Eye problems/disorders: None of the above	0.6	0.7	1.7	0.6	1.1	1.3	-0.0	0.3
Heart disease (mother)	0.6	0.8	1.6	-1.0	1.2	1.0	-0.1	0.7
Alcohol intake frequency.	0.6	1.4	5.6	-0.3	-0.6	0.3	-2.4	-0.9
Commuting to job workplace: Walk	0.6	0.7	2.6	0.0	0.2	-1.6	0.8	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.9	0.9	-0.4	1.3	1.4	0.6
Ever taken oral contraceptive pill	0.6	0.6	1.5	1.1	1.2	0.5	0.2	0.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.6	0.8	1.6	-0.1	-0.6	0.4
Medication: Atorvastatin	0.6	0.7	1.4	-0.3	-0.1	1.1	1.2	0.8
Alzheimer’s Disease (in father)	0.5	0.5	1.6	-0.0	0.6	0.8	1.3	0.2
Alzheimer’s Disease (including proxy)	0.5	0.7	3.2	-0.3	-0.1	-0.1	1.8	0.2
Breast Cancer	0.5	1.3	2.6	1.3	0.5	0.1	1.3	1.6
Rheumatoid Arthritis	0.5	0.7	3.1	-1.8	-0.3	0.1	-0.1	-0.3
Triglycerides	0.5	0.8	1.9	1.4	-0.5	0.3	-1.2	-0.8
Allergy or Eczema	0.5	1.4	7.0	-2.6	0.1	0.1	0.2	0.3
Respiratory disease	0.5	1.2	2.6	0.0	1.6	1.0	-1.4	-0.1
Chronotype (morning person)	0.5	1.2	3.0	-1.5	-1.7	-0.4	-0.1	-0.6
Average weekly spirits intake	0.5	0.6	1.6	-1.3	-1.0	-0.4	0.1	-0.4
Systolic blood pressure, automated reading	0.5	1.6	5.3	-2.3	0.3	-1.5	-0.1	-0.6
Medication: Co-codamol	0.5	0.6	1.2	0.6	1.1	0.7	1.0	0.2
Diabetes (father)	0.5	0.6	2.6	-0.2	-0.0	-1.6	-0.6	-0.4
Severe depression (siblings)	0.5	0.6	1.3	-1.1	-0.0	-0.4	-1.0	-0.6
Hayfever, allergic rhinitis or eczema	0.5	1.1	4.8	-2.2	-0.7	-0.3	-0.6	-0.0
Forced vital capacity (FVC)	0.5	2.1	6.7	0.5	-2.6	-1.3	-0.0	-1.4
Medication: Simvastatin	0.5	0.7	2.4	-1.6	0.1	0.6	-0.8	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	5.3	1.1	-2.3	-1.2	-0.2	-0.8
Birth weight of first child	0.5	0.8	2.4	-0.3	0.1	1.1	1.6	0.7
Glaucoma (self-reported)	0.5	0.5	1.9	1.4	-0.0	0.4	-0.7	0.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.1	0.5	-0.1	-0.3	-1.4	-0.6
Medication: Ibuprofen	0.5	0.6	1.0	0.6	1.0	0.8	1.0	0.2
Family relationship satisfaction	0.5	0.7	1.8	-0.9	0.2	-0.4	-1.4	0.7
Medication: Aspirin	0.5	0.7	1.6	0.1	-0.3	1.3	1.1	0.6
Supplements: Vitamin C	0.5	0.6	2.5	0.2	-1.6	-0.4	0.1	-0.6
Illnesses of siblings: Diabetes	0.5	0.6	2.2	-1.5	0.2	-0.5	0.1	0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.4	1.1	1.2	-0.3	0.1	-0.1
Miserableness	0.5	0.9	2.7	0.7	0.9	1.6	-0.3	0.6
Eye problems/disorders: Glaucoma	0.5	0.6	1.5	1.2	0.3	0.1	-1.2	0.5
High cholesterol (Self-reported)	0.5	1.0	3.8	-2.0	-0.4	0.5	0.7	0.3
Diastolic blood pressure, automated reading	0.5	1.7	4.2	-1.4	2.0	0.2	0.2	1.5
Commuting to job workplace: Cycle	0.5	0.6	2.0	-0.2	0.5	0.1	0.9	1.4
Depressed Affect (Nagel 2018)	0.4	0.8	3.8	-0.0	-0.1	0.5	-1.9	-0.0
Age at First Birth	0.4	0.5	2.4	-0.1	0.4	0.2	1.6	-0.3
HDL Cholesterol	0.4	0.6	1.1	-0.5	0.5	-0.7	1.1	0.9
LDL Cholesterol	0.4	0.7	1.7	1.0	-0.0	-0.7	-0.3	-1.3
Schizophrenia (2014)	0.4	0.9	2.1	0.7	0.4	1.2	0.4	1.5
Lung FVC	0.4	1.9	4.0	1.4	-2.0	-1.4	0.6	-1.0
Hand grip strength (left)	0.4	1.0	2.2	-1.5	1.0	-0.2	1.3	-0.1
Relative age of first facial hair	0.4	0.8	1.5	1.2	-0.7	-0.4	-0.8	-1.0
Angina	0.4	0.5	2.2	-1.5	0.0	0.0	-0.5	-0.1
Diabetes (mother)	0.4	0.5	1.0	-1.0	0.4	-0.8	-0.6	0.5
Relative age voice broke	0.4	0.6	1.6	0.2	-1.3	-0.4	0.1	-1.1
Mouth/teeth dental problems	0.4	0.7	2.9	-1.7	0.1	-0.5	-0.2	-0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.8	-0.8	-1.3	0.0	-0.6	-0.1
Number of live births	0.4	0.6	1.7	-0.8	0.0	-0.5	-1.3	-0.5
Medication: Cholesterol lowering	0.4	0.6	1.4	-0.6	0.4	1.2	-0.2	1.1
Breastfed as a baby	0.4	0.5	1.2	0.2	-0.2	-0.1	1.1	1.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	0.7	-0.9	-0.2	1.3	-0.3
Forced vital capacity (FVC), Best measure	0.4	1.3	4.1	1.0	-2.0	-1.1	0.1	-0.7
Age at first live birth	0.4	0.8	2.7	1.7	0.5	0.4	0.8	0.3
Angina (self-reported)	0.4	0.5	1.8	-1.3	-0.0	-0.1	-0.7	-0.0
Mean time to correctly identify matches	0.4	0.8	1.4	-0.8	-1.2	-0.9	0.5	-1.1
Suffer from ‘nerves’	0.4	0.6	1.7	0.1	1.0	0.2	-1.3	0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.9	1.4	-0.4	0.0	0.2	-0.3
Mood swings	0.4	0.8	3.0	0.6	0.5	0.3	-1.7	0.1
Medication: Aspirin	0.4	0.6	1.4	0.3	-0.1	1.2	1.0	0.7
Number of self-reported non-cancer illnesses	0.4	0.7	1.3	0.1	1.2	1.1	0.9	0.4
Average weekly champagne plus white wine intake	0.4	0.5	1.1	1.0	0.8	-0.4	0.8	-0.2
Alcohol drinker status: Never	0.4	0.4	1.8	-0.0	-1.3	0.0	0.2	-0.6
Basal cell carcinoma (self-reported)	0.4	0.5	1.6	-0.2	-1.3	0.3	-0.0	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.7	1.3	-0.6	0.6	0.2	-0.1
Schizophrenia (2018)	0.3	0.6	1.4	0.1	0.3	0.5	1.2	1.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	1.0	0.4	0.4	-0.2	0.8
Crohns Disease (2017)	0.3	0.6	0.9	0.7	0.8	0.7	1.0	-0.7
Major Depression (MDD)	0.3	0.4	1.2	0.1	0.5	0.8	-1.1	-0.1
Ovarian Cancer	0.3	0.4	1.0	1.0	-0.2	0.6	0.6	0.5
Mean Putamen Volume	0.3	0.4	0.9	0.9	-0.1	-0.1	-0.7	0.7
Neuroticism (2016)	0.3	0.4	1.0	0.2	0.6	1.0	0.3	0.6
Primary Biliary Cirrhosis	0.3	0.5	1.1	0.5	-0.2	-0.2	-1.1	-0.9
Waist Hip Ratio (WHR)	0.3	1.3	1.9	-0.7	1.4	-1.4	-1.3	-0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	0.7	-0.3	0.6	-1.0	-0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	-0.3	-0.0	0.6	0.8	0.8
Impedance of leg (right)	0.3	1.3	2.0	0.6	-1.4	-1.2	-1.1	-1.3
Hand grip strength (right)	0.3	0.8	1.9	-1.4	-0.0	-0.8	1.0	-0.9
Maternal smoking around birth	0.3	0.5	1.3	0.7	1.1	0.6	0.5	0.2
Stomach or abdominal pain in last month	0.3	0.4	1.4	1.2	0.7	0.3	0.4	0.1
Allergy	0.3	0.6	1.2	0.7	0.9	0.1	1.1	0.8
Diabetes (self-reported)	0.3	0.5	1.1	1.0	0.6	1.0	-0.3	0.2
Neuroticism score	0.3	0.7	3.0	0.1	-0.3	-0.1	-1.7	-0.7
Impedance of arm (right)	0.3	1.5	5.4	0.7	-2.3	-0.1	0.1	-1.3
Time employed in main current job	0.3	0.3	1.2	-0.0	0.2	-0.7	1.1	-0.0
Hair/balding pattern: Pattern 3	0.3	0.4	2.0	1.4	0.1	0.1	0.0	0.1
Happiness	0.3	0.4	1.6	-0.4	0.0	0.6	-1.2	-0.0
Asthma	0.3	0.5	1.0	0.4	1.0	0.6	-0.9	-0.4
Depression (self-reported)	0.3	0.3	0.8	0.2	-0.2	-0.9	-0.3	-0.8
Impedance of arm (left)	0.3	1.4	5.0	0.8	-2.2	0.2	0.7	-1.0
Hair/balding pattern: Pattern 4	0.3	0.6	1.4	-1.2	0.7	0.6	-0.3	0.8
Leg fat percentage (right)	0.3	1.1	2.2	-0.1	0.8	-1.5	-1.4	-0.8
Back pain experienced in last month	0.3	0.4	1.9	0.1	1.4	0.2	0.3	0.1
Guilty feelings	0.3	0.4	1.2	1.1	-0.4	0.5	-0.4	-0.6
Illnesses of father: High blood pressure	0.3	0.4	0.9	1.0	-0.7	0.1	0.6	-0.1
Leg fat percentage (left)	0.3	0.9	2.3	-0.6	0.9	-1.5	-0.9	-0.7
Bipolar Disorder or Schizophrenia	0.2	0.4	0.7	0.8	-0.7	0.6	0.4	0.5
Prostate Cancer	0.2	0.3	0.5	0.5	0.7	0.2	0.5	-0.5
Fasting Glucose	0.2	0.3	0.5	0.1	0.7	0.5	0.5	0.5
Blood Platelet Count	0.2	2.2	5.0	-2.2	0.9	-1.9	0.9	0.9
Blood White Count	0.2	1.2	2.9	-0.0	1.7	1.4	0.5	1.1
BMI	0.2	0.9	1.8	-1.2	1.1	-0.0	-1.3	0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	-0.1	0.3	-0.4	-0.9	-0.6
Medication: Metformin	0.2	0.3	0.9	0.5	0.3	0.1	-0.7	-0.9
Medication: Levothyroxine sodium	0.2	0.4	0.7	0.9	-0.1	-0.2	-0.7	-0.8
Sitting height	0.2	1.6	5.1	-0.7	-0.3	0.6	2.3	1.4
Impedance of leg (left)	0.2	0.9	1.8	-0.0	-1.4	-1.1	-0.4	-1.1
Waist circumference	0.2	0.7	1.5	-1.0	1.2	-0.7	-0.8	-0.3
Number of incorrect matches in round	0.2	0.4	0.6	-0.5	-0.6	-0.8	0.2	-0.7
Had menopause	0.2	0.3	0.6	0.8	-0.5	-0.3	0.4	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	0.9	-0.0	-0.1	0.2	-0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	0.6	0.7	-0.5	-0.6	0.5
Comparative body size at age 10	0.2	0.6	1.4	-1.2	-0.8	-0.6	0.3	-0.7
Worry too long after embarrassment	0.2	0.4	0.7	0.7	-0.9	-0.4	-0.2	-0.6
Qualifications: College or University degree	0.2	0.8	2.2	-0.5	-0.6	-1.0	1.5	-0.2
Medication: Omeprazole	0.2	0.3	1.0	0.1	1.0	0.4	-0.6	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.1	0.7	-0.3	-0.6	-0.2
Leg fat mass (right)	0.2	0.8	1.6	-0.4	0.7	-1.3	-1.1	-0.8
Comparative height size at age 10	0.2	1.3	3.5	-0.8	-1.9	-0.6	1.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.8	0.2	-0.9	-0.3	-0.8	-0.8
Friendships satisfaction	0.2	0.2	0.4	-0.2	-0.1	-0.6	-0.6	-0.5
Qualifications: nursing, teaching	0.2	0.4	1.1	0.1	-1.1	-0.8	0.1	0.0
Asthma (self-reported)	0.2	0.4	0.9	0.3	1.0	0.8	-0.7	-0.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.5	0.3	-0.0	-0.6	0.5
Number of operations (self-reported)	0.2	0.3	0.9	-0.1	0.8	0.3	-0.0	0.9
Average weekly beer plus cider intake	0.2	0.3	0.7	-0.2	0.6	-0.3	-0.8	-0.6
Fractured/broken bones in last 5 years	0.2	0.3	1.0	-0.6	1.0	0.0	-0.2	0.2
Impedance of whole body	0.2	1.1	3.6	0.7	-1.9	-0.3	0.4	-1.1
Leg fat mass (left)	0.2	0.7	1.7	-0.5	0.7	-1.3	-0.8	-0.7
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.7	0.1	0.2	-0.4	-0.1	-0.8
Blood Eosinophil Count	0.1	0.9	1.6	1.1	1.3	0.8	-1.0	0.4
Blood Red Count	0.1	1.3	2.2	0.9	1.5	1.2	-0.3	1.4
Height	0.1	1.9	6.3	0.6	-0.0	1.4	2.5	1.0
Cardiovascular Disease	0.1	0.5	1.7	0.2	0.2	0.7	1.3	0.1
Hypothyroidism (self reported)	0.1	0.2	0.4	0.5	0.5	-0.0	-0.6	0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	0.1	0.6	0.7	0.2	-0.2
Lung FEV1/FVC ratio	0.1	0.7	1.0	0.5	-1.0	-1.0	-0.8	-0.8
Tanning	0.1	0.9	1.9	-1.4	0.7	-0.5	-0.7	1.1
Age when periods started (menarche)	0.1	0.3	1.2	-1.1	0.5	-0.0	-0.1	-0.3
Body mass index (BMI)	0.1	0.6	1.7	-0.6	1.3	-0.6	-0.7	0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	0.1	0.4	0.6	-0.3	0.4
Weight	0.1	0.4	0.9	-0.8	0.9	-0.3	-0.3	0.2
Arm fat percentage (right)	0.1	0.4	0.7	-0.1	0.3	-0.8	-0.8	-0.8
Trunk fat-free mass	0.1	0.4	1.0	-1.0	0.1	-0.8	-0.6	0.2
Hip circumference	0.1	0.3	0.8	-0.6	0.9	-0.3	-0.5	-0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	0.2	-0.1	-0.7	0.6	0.3
Prospective memory result	0.1	0.1	0.2	-0.5	-0.0	0.2	-0.3	-0.5
Arm fat mass (right)	0.1	0.4	0.7	-0.5	0.5	-0.8	-0.6	-0.6
Trunk predicted mass	0.1	0.5	1.0	-1.0	0.1	-0.9	-0.7	0.1
Tense / ‘highly strung’	0.1	0.2	0.7	-0.1	-0.2	-0.6	-0.8	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	0.7	0.1	-0.1	-0.6	-0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	0.2	0.4	0.6	-0.4	-0.1
Arm fat-free mass (right)	0.1	0.7	1.4	-1.2	0.9	-0.6	-0.7	0.2
Migraine (self-reported)	0.1	0.1	0.2	0.2	-0.2	0.4	-0.3	0.4
Whole body fat mass	0.1	0.2	0.5	-0.4	0.4	-0.7	-0.1	-0.5
Arm predicted mass (right)	0.1	0.4	0.6	-0.8	0.8	-0.7	-0.5	0.1
Age at last live birth	0.1	0.1	0.2	0.3	0.4	0.1	0.3	0.4
Whole body fat-free mass	0.1	0.3	0.7	-0.9	0.3	-0.7	-0.5	-0.0
Arm fat percentage (left)	0.1	0.3	0.5	-0.3	0.4	-0.7	-0.6	-0.6
Arm fat mass (left)	0.1	0.3	0.6	-0.4	0.5	-0.8	-0.4	-0.2
Arm fat-free mass (left)	0.1	0.5	1.3	-0.8	0.6	-1.1	-0.6	0.1
Myopia	0.1	0.1	0.4	-0.6	-0.3	0.3	-0.1	-0.2
Arm predicted mass (left)	0.1	0.6	0.9	-0.9	0.8	-0.9	-0.8	0.1
Heel T-Score	0.0	0.1	0.2	-0.3	-0.3	0.5	0.3	-0.1
Hair Pigment	0.0	0.5	1.2	-0.0	-0.8	0.3	1.1	-0.5
Leg fat-free mass (left)	0.0	0.1	0.2	-0.4	0.4	-0.2	-0.3	-0.1
Trunk fat percentage	0.0	0.1	0.3	-0.1	0.6	0.1	0.2	-0.4
Leg predicted mass (left)	0.0	0.1	0.2	-0.4	0.4	-0.2	-0.3	-0.1
Trunk fat mass	0.0	0.1	0.3	-0.4	0.5	-0.3	0.1	-0.3
Standing height	0.0	0.5	1.1	-0.5	-1.0	0.2	1.0	0.1
Body fat percentage	0.0	0.2	0.5	-0.3	0.7	-0.4	-0.3	-0.4
Leg fat-free mass (right)	0.0	0.2	0.6	-0.8	0.5	-0.1	0.3	0.0
Whole body water mass	0.0	0.3	0.6	-0.8	0.4	-0.6	-0.4	0.1
Leg predicted mass (right)	0.0	0.2	0.5	-0.7	0.5	-0.1	0.2	0.1
Basal metabolic rate	0.0	0.2	0.5	-0.7	0.5	-0.5	-0.4	0.1

Hub : Genes

ACTN2

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Trait associations