Best TWAS P=6.07e-09 · Best GWAS P=1.62e-08 conditioned to 0.0349
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | PHACTR4 | 0.26 | 0.27 | lasso | 8 | 0.21 | 8.7e-12 | 5.3 | -5.7 | 1.5e-08 | -0.96 | 0.03 | 0.97 | FALSE |
2 | GTEx | Artery Coronary | PHACTR4 | 0.12 | 0.20 | lasso | 2 | 0.18 | 1.0e-06 | 5.3 | -5.3 | 9.8e-08 | -0.97 | 0.03 | 0.96 | FALSE |
3 | GTEx | Brain Cerebellum | PHACTR4 | 0.20 | 0.14 | lasso | 16 | 0.13 | 1.4e-04 | 5.4 | -5.3 | 8.9e-08 | -0.98 | 0.02 | 0.95 | FALSE |
4 | GTEx | Brain Frontal Cortex BA9 | PHACTR4 | 0.20 | 0.18 | lasso | 4 | 0.19 | 9.4e-06 | 4.8 | -5.2 | 2.5e-07 | -0.97 | 0.04 | 0.89 | FALSE |
5 | GTEx | Colon Transverse | SNHG12 | 0.11 | -0.01 | lasso | 5 | 0.00 | 6.7e-01 | 5.3 | -5.8 | 6.1e-09 | -0.72 | 0.03 | 0.71 | TRUE |
6 | GTEx | Spleen | SNHG3 | 0.15 | 0.09 | lasso | 6 | 0.07 | 6.8e-03 | 5.3 | 5.4 | 5.3e-08 | 0.91 | 0.04 | 0.78 | FALSE |
7 | NTR | Blood | PHACTR4 | 0.01 | 0.01 | enet | 8 | 0.01 | 2.6e-05 | 5.2 | -5.1 | 2.8e-07 | -0.79 | 0.02 | 0.97 | FALSE |
8 | YFS | Blood | PHACTR4 | 0.14 | 0.28 | bslmm | 323 | 0.28 | 3.5e-92 | 5.5 | -5.2 | 1.6e-07 | -0.99 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PHACTR4 | 0.02 | 0.02 | enet | 3 | 0.02 | 2.9e-03 | 5.4 | -5.5 | 3.2e-08 | -0.93 | 0.02 | 0.80 | FALSE |