TWAS hub - SNHG12

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.106	0.0565	0.00730	-0.006	NA	0.007	NA	-0.008	0.6100	NA	0.180	NA	0.840
2	GTEx	Colon Transverse	0.111	0.0620	0.00690	-0.006	NA	-0.006	NA	-0.005	0.8300	NA	0.820	NA	0.670
3	GTEx	Esophagus Muscularis	0.050	0.0240	0.00230	0.010	NA	0.003	NA	0.005	0.0760	NA	0.190	NA	0.160
4	GTEx	Lung	0.128	0.0590	0.00210	0.001	NA	0.011	NA	0.009	0.2500	NA	0.041	NA	0.065
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.081	0.0650	0.00390	0.009	0.004	0.006	NA	0.014	0.0910	0.170	0.130	NA	0.050
6	TCGA	Thyroid Carcinoma	0.085	0.0570	0.00082	0.018	0.009	0.010	NA	0.015	0.0065	0.043	0.034	NA	0.011

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3	4	5	6
Average weekly red wine intake	4.7	6.9	14.5	0.7	2.8	3.8	3.1	3.0
Respiratory disease	4.6	10.2	16.3	-4.0	-3.7	-0.9	-3.9	-4.0
Age started oral contraceptive pill	4.5	5.6	10.2	3.0	3.2	0.9	2.7	2.5
Maternal smoking around birth	4.4	6.4	13.8	-2.2	-3.7	1.1	-2.8	-3.2
Ever unenthusiastic/disinterested for a whole week	4.3	5.2	10.4	-1.1	-2.4	-3.2	-2.8	-2.5
Pulse rate, automated reading	4.3	14.0	33.8	-5.8	-4.6	0.2	-4.2	-3.5
Ever depressed for a whole week	4.3	5.2	14.6	-1.7	-2.1	-3.8	-2.3	-2.1
Birth weight of first child	3.8	6.9	13.7	-3.7	-3.3	-1.3	-2.7	-2.7
Smoking status: Current	3.8	6.0	12.3	-3.1	-3.5	0.1	-2.8	-2.5
Major Depression (MDD)	3.7	4.5	9.9	-0.6	-2.4	-3.1	-2.6	-2.0
Hair/balding pattern: Pattern 3	3.4	5.0	15.1	1.7	3.9	-1.6	2.0	2.4
Loud music exposure frequency	3.4	3.7	7.9	-1.4	-2.0	-0.9	-2.8	-2.8
Qualifications: College or University degree	3.4	10.7	19.5	1.6	3.3	4.4	4.0	3.9
Illness, injury, bereavement, stress in last 2 years	3.4	4.1	7.6	2.2	2.6	0.2	2.8	2.4
Medication: Omeprazole (e.g. Zanprol)	3.4	4.1	9.3	-1.5	-1.4	-3.0	-2.8	-1.9
Severe depression (siblings)	3.2	3.5	5.9	-1.8	-2.4	-2.1	-2.2	-1.6
Had other major operations	3.2	3.9	8.4	-1.2	-1.9	-1.6	-2.9	-2.7
Emphysema/chronic bronchitis	3.2	3.6	6.4	-2.5	-2.5	-0.6	-2.2	-1.9
Schizophrenia (2018)	3.0	6.3	22.9	-2.3	-1.2	-4.8	-2.5	-1.4
Exposure to tobacco smoke outside home	2.9	3.8	8.1	-2.3	-2.8	0.7	-1.6	-2.6
Vitamin and mineral supplements	2.8	3.8	7.7	-2.8	-0.8	-2.0	-2.7	-1.7
Current tobacco smoking	2.7	4.5	9.5	-2.3	-3.1	0.4	-2.5	-2.3
Qualifications: CSEs or equivalent	2.7	3.6	9.2	-1.5	-3.0	-1.0	-2.0	-2.3
Multivitamins +/- minerals	2.7	3.5	6.1	2.5	1.7	1.6	2.5	1.8
Medication: Ventolin 100micrograms inhaler	2.7	3.5	7.4	-2.1	-2.7	-0.1	-2.0	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.3	5.0	-1.6	-1.9	-2.2	-2.0	-2.2
Qualifications: nursing, teaching	2.6	4.1	19.6	0.4	0.9	4.4	1.9	0.5
Qualifications: None of the above	2.5	5.2	8.2	-2.5	-2.9	-2.5	-2.5	-2.0
Systolic Blood Pressure	2.4	11.8	25.2	5.0	4.0	3.4	3.1	3.0
Pack years adult smoking proportion	2.4	3.7	7.8	-1.8	-2.8	-1.8	-2.2	-1.8
Crohns Disease (2017)	2.2	4.9	13.7	-1.3	-2.7	1.1	-2.4	-3.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	9.4	-0.6	-2.1	-3.1	-1.6	-1.9
Medication: Omeprazole	2.2	2.7	7.6	-0.5	-0.8	-2.8	-2.0	-1.9
Asthma (self-reported)	2.2	4.3	8.5	-2.3	-2.5	0.7	-2.2	-2.9
Pack years of smoking	2.2	3.2	6.9	-1.6	-2.6	-1.8	-2.0	-1.6
Schizophrenia (2014)	2.1	4.7	23.2	-1.8	-1.2	-4.8	0.0	0.0
Allergy	2.1	4.8	12.8	2.2	1.9	0.5	2.7	3.6
Chronic bronchitis/emphysema (mother)	2.1	2.4	4.7	-2.0	-1.3	-0.5	-2.0	-2.2
Medication: Aspirin	2.1	2.7	5.9	1.1	1.8	1.6	1.8	2.4
Smoking Status	2.0	4.8	8.3	-2.8	-2.9	0.8	-2.3	-2.5
Comparative body size at age 10	2.0	5.5	9.5	3.1	2.6	2.1	2.4	2.6
Wheeze or whistling in the chest in last year	2.0	3.6	6.5	-1.7	-2.5	-0.2	-2.5	-2.4
Age at first live birth	2.0	3.6	8.5	2.6	2.9	0.5	1.9	1.4
Back pain experienced in last month	2.0	3.0	5.7	-1.1	-1.9	-1.6	-2.2	-2.4
Supplements: Fish oil (including cod liver oil)	2.0	2.7	4.7	0.7	1.8	1.9	2.2	2.0
Cholesterol lowering medication	2.0	3.0	5.3	-2.3	-2.0	-1.1	-1.9	-2.0
Medication: Aspirin	1.9	2.5	5.3	1.1	1.6	1.6	1.9	2.3
Mineral and other dietary supplements	1.9	2.5	6.1	-0.8	-1.6	-1.8	-2.5	-1.6
Blood Eosinophil Count	1.8	13.8	35.2	2.9	3.4	3.8	3.6	5.9
Noisy workplace	1.8	2.2	4.4	-0.9	-2.0	-2.1	-1.7	-1.0
Overall health rating	1.8	3.8	10.8	0.4	-1.8	-3.3	-2.1	-2.0
Had major operations	1.8	2.1	4.7	0.7	1.3	2.2	1.4	1.9
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	5.2	1.9	2.2	0.4	2.3	1.9
Medication for hormone replacement therapy	1.7	1.9	5.4	-0.9	-1.4	-2.3	-1.1	-1.6
Medication: Ramipril	1.7	2.2	7.9	1.1	1.7	2.8	0.9	0.5
Asthma	1.7	3.4	7.3	-1.8	-2.3	1.1	-1.9	-2.7
Worry too long after embarrassment	1.7	2.9	9.7	3.1	0.7	1.6	2.0	0.7
Medication: Ibuprofen	1.7	2.0	3.4	-0.9	-1.7	-1.5	-1.8	-1.5
Heart disease (mother)	1.7	2.0	4.6	1.1	2.1	-0.4	1.8	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	3.6	-0.1	-1.9	-1.7	-1.7	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	5.4	-2.3	-1.7	-0.6	-1.7	-1.2
Irritable Bowel Disease (IBD)	1.6	3.8	12.4	-1.1	-1.8	0.6	-2.4	-3.5
Pulse rate	1.6	2.7	6.6	-2.6	-2.1	0.8	-1.3	-1.5
Happiness	1.6	1.9	7.8	-0.1	0.1	-2.8	-1.5	-1.3
Prospective memory result	1.6	1.9	3.9	-1.6	-1.3	-0.8	-2.0	-1.7
Blood clot in the leg (DVT)	1.6	2.1	4.6	-2.1	-1.8	-0.7	-1.6	-1.3
Bipolar Disorder or Schizophrenia	1.5	3.6	18.4	-1.3	-1.1	-4.3	0.0	0.0
Depression (Nagel 2018)	1.5	2.2	8.4	0.7	-0.1	-2.9	-1.2	-1.7
Alzheimer’s Disease (in mother)	1.5	1.7	6.2	2.5	1.3	0.6	0.8	1.2
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.8	1.9	1.8	-0.5	1.4	1.3
Medication: Atenolol	1.5	1.9	4.8	2.2	1.3	1.6	1.0	1.2
Guilty feelings	1.5	2.2	9.2	3.0	0.7	1.3	1.4	0.4
Ever used hormone-replacement therapy (HRT)	1.4	1.8	5.5	-0.8	-0.2	-2.4	-1.3	-1.6
Systolic blood pressure, automated reading	1.4	4.0	12.4	3.5	2.3	1.3	1.8	1.4
High blood pressure	1.4	3.8	9.1	3.0	2.1	2.0	1.3	1.9
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	4.0	1.7	2.0	1.4	1.7	1.2
Medication: Blood pressure	1.4	2.5	6.1	1.8	1.1	2.5	1.0	1.8
Medication: Seretide 50 evohaler	1.4	1.6	4.9	0.1	-2.2	0.4	-1.0	-1.8
Commuting to job workplace: Car/motor vehicle	1.4	1.6	5.7	-0.4	-0.7	-1.0	-1.5	-2.4
Tinnitus: Yes, now most or all of the time	1.4	1.6	2.9	-0.8	-1.7	-1.5	-1.5	-1.2
Risk taking	1.4	2.1	5.7	-0.9	-1.6	-0.7	-1.7	-2.4
Vascular/heart problems diagnosed by doctor	1.4	3.9	6.7	-2.6	-2.5	-2.2	-1.3	-2.1
Hypothyroidism (self reported)	1.3	3.0	7.4	2.7	2.3	0.8	1.8	1.2
Ever had hysterectomy (womb removed)	1.3	1.4	3.5	0.5	0.2	1.4	1.7	1.9
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	4.7	-1.6	-0.9	-2.2	-0.9	-0.0
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	4.5	2.1	2.0	0.2	1.1	1.3
Basal cell carcinoma (self-reported)	1.3	1.6	4.8	-2.0	-2.2	-0.4	-0.7	-0.1
Waist Hip Ratio (WHR)	1.2	5.4	17.0	-4.1	-2.4	-0.8	-2.4	-1.9
Supplements: Zinc	1.2	1.3	3.5	-0.5	-1.8	1.9	1.0	0.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	3.1	-0.8	-1.8	-1.4	-1.5	-1.3
Breastfed as a baby	1.2	1.5	2.5	1.6	1.3	0.7	1.3	1.5
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.7	-1.6	-0.3	-2.2	-1.1	-1.8
Number of full brothers	1.2	1.5	5.2	-1.0	-2.3	0.8	-0.9	-1.1
Health satisfaction	1.2	1.5	5.6	1.6	-0.9	-2.4	-0.2	0.1
Leg pain on walking	1.2	1.5	4.3	1.2	-0.4	-2.1	-1.6	-0.7
Intelligence (Savage-Jansen 2018)	1.1	3.3	7.5	2.4	2.7	0.1	1.3	2.2
Schizophrenia vs Biploar Disorder	1.1	1.4	7.5	-0.9	-0.3	-2.7	0.0	0.0
Neuroticism	1.1	2.7	9.5	3.1	1.9	-1.1	1.4	-0.1
Number of live births	1.1	1.6	5.2	-0.4	-2.3	0.1	-1.2	-1.7
Hypertension (Self-reported)	1.1	3.1	6.4	2.5	2.0	1.8	1.2	1.9
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.2	-1.1	-0.3	-1.8	-1.2	-1.3
Breast cancer (self-reported)	1.1	1.4	2.9	1.1	1.7	0.9	1.6	0.9
Average weekly champagne plus white wine intake	1.1	1.5	3.6	-0.0	0.8	1.9	1.2	1.7
Ever smoked	1.1	2.0	5.2	-2.3	-1.1	0.7	-1.5	-1.6
Alzheimer’s Disease (including proxy)	1.0	1.4	3.2	1.8	1.8	0.1	0.9	1.1
HbA1C	1.0	1.1	2.4	0.6	-0.7	-1.2	-1.6	-1.4
Hand grip strength (right)	1.0	2.7	6.0	-2.2	-1.4	0.9	-1.6	-2.4
Hearing difficulty/problems with background noise	1.0	1.6	4.8	0.2	1.0	-2.2	1.3	1.6
Worrier / anxious feelings	1.0	1.8	8.8	3.0	1.0	-0.3	1.0	0.2
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.3	1.6	1.8	1.6	1.8	1.2
Exposure to tobacco smoke at home	1.0	1.1	3.6	-1.9	-1.3	0.5	-0.9	-0.5
Financial situation satisfaction	1.0	1.2	4.2	1.1	0.9	-2.0	-1.0	-0.1
Medication: Bendroflumethiazide	1.0	1.4	2.9	1.5	1.7	1.4	0.7	1.0
Alcohol drinker status: Never	1.0	1.2	4.2	-0.3	-0.6	-2.1	-1.0	-1.1
Reaction Time	0.9	1.8	3.7	-1.2	-1.8	-0.2	-1.9	-1.5
Verbal and Numeric Reasoning (VNR)	0.9	2.3	5.0	1.8	1.8	0.5	1.4	2.2
Mean Putamen Volume	0.9	1.0	2.6	1.6	1.4	-0.4	0.8	0.8
Hand grip strength (left)	0.9	2.4	6.6	-1.4	-1.4	1.2	-1.5	-2.6
Diabetes (father)	0.9	1.2	2.1	-1.5	-1.3	1.4	-0.5	-0.9
Hair/balding pattern: Pattern 2	0.9	1.1	3.1	0.0	-0.4	1.7	-0.6	-1.8
Knee pain experienced in last month	0.9	1.3	2.5	1.6	1.3	0.5	1.3	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.9	-1.5	-1.6	2.2	-0.5	-1.2
Long-standing illness, disability or infirmity	0.9	1.4	3.7	-0.9	-1.3	-0.4	-1.5	-1.9
Eye problems/disorders: Glaucoma	0.9	1.1	5.5	0.0	0.3	2.3	0.7	0.7
Commuting to job workplace: Cycle	0.9	1.1	2.7	0.5	1.4	1.6	0.8	1.2
Heart disease (siblings)	0.9	1.1	2.4	0.9	1.3	-1.5	0.8	1.2
Neuroticism (Nagel 2018)	0.8	1.9	5.8	2.4	1.0	-2.0	0.2	-0.8
Worry (Nagel 2018)	0.8	1.6	4.9	2.0	0.6	-2.2	0.1	-0.7
Allergy or Eczema	0.8	2.0	7.3	-0.7	-1.1	-0.3	-1.6	-2.7
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.2	-0.8	-0.6	-1.5	-1.4	-1.0
Medication: Metformin	0.8	1.2	3.7	-1.7	-0.3	0.5	-1.9	-0.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.4	-1.0	-0.8	0.8	-1.2	-1.5
Length of working week for main job	0.8	0.9	1.8	-1.0	0.4	1.4	-1.1	-1.1
Medication: Amlodipine	0.8	1.1	4.7	0.0	-0.1	2.2	0.7	1.1
Neck or shoulder pain in last month	0.8	1.1	3.6	-0.5	-0.3	-1.5	-0.9	-1.9
Mean time to correctly identify matches	0.8	1.6	3.2	-1.3	-1.4	-0.6	-1.8	-1.5
Age at last live birth	0.8	1.1	3.5	1.9	1.4	0.3	0.9	0.6
Commuting to job workplace: Walk	0.8	0.8	3.0	0.2	0.1	-1.3	0.5	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.8	-1.2	-1.3	-0.8	-0.9	-1.1
Alzheimer’s Disease (in father)	0.7	0.7	3.2	-0.2	1.8	-0.8	0.7	0.4
Blood White Count	0.7	5.5	10.1	2.0	2.3	2.2	2.9	3.2
Past tobacco smoking	0.7	1.2	3.8	1.9	0.9	-0.4	1.2	1.1
Alcohol usually taken with meals	0.7	1.2	2.7	-1.6	1.2	0.9	0.5	1.3
Pain all over the body in last month	0.7	0.8	3.4	-0.0	-0.7	-1.8	-0.8	-0.2
Diabetes (self-reported)	0.7	1.1	2.1	-1.4	-1.4	1.0	-1.0	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.9	-1.4	-1.1	0.2	-1.2	-0.1
Medication: Cholesterol lowering	0.7	1.0	3.3	1.8	0.8	0.6	0.7	1.2
Lung cancer (father)	0.7	0.8	2.1	-1.0	-1.4	-0.2	-0.9	-0.8
Illnesses of siblings: Diabetes	0.7	0.9	2.9	-0.8	1.1	1.7	0.4	0.4
Commuting to job workplace: Public transport	0.7	0.8	1.9	1.4	1.1	-0.6	0.3	1.2
Medication: Lisinopril	0.7	0.9	3.4	0.6	1.4	-0.2	0.2	1.8
Depressed Affect (Nagel 2018)	0.6	1.2	4.3	1.1	0.8	-2.1	-0.3	-1.0
Lung FVC	0.6	2.8	8.0	-2.1	-0.2	-2.8	-2.0	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.5	0.8	-0.8	-1.2	-0.6	-1.2
Hayfever, allergic rhinitis or eczema	0.6	1.3	5.9	-0.5	-0.5	0.1	-1.2	-2.4
Nervous feelings	0.6	1.1	5.3	2.3	1.0	-0.1	0.5	0.1
Illnesses of siblings	0.6	0.9	2.4	-0.8	-1.2	-0.1	-0.7	-1.6
Neuroticism score	0.6	1.2	6.4	2.5	0.5	-0.0	0.5	-0.7
Illnesses of mother	0.6	0.7	2.5	-1.6	-0.8	-0.5	-0.5	-0.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.9	-0.3	0.5	-1.7	-0.9	-0.6
Glaucoma (self-reported)	0.6	0.7	1.3	0.9	0.5	0.8	1.0	1.2
Number of children fathered	0.6	0.6	1.6	-1.3	-1.2	0.7	-0.5	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.6	0.7	1.3	0.1	1.1	0.8
Shortness of breath walking on level ground	0.6	0.7	3.2	1.8	-0.5	0.4	-0.3	0.5
Comparative height size at age 10	0.6	3.3	14.8	1.6	0.4	3.9	1.4	0.1
Irritability	0.6	1.0	3.2	1.5	1.8	-0.5	0.1	-0.7
Ulcerative Colitis (UC)	0.5	0.9	2.9	-0.4	-0.6	-0.2	-1.4	-1.7
Fasting Glucose	0.5	0.6	2.5	-1.0	-1.6	0.5	0.0	0.0
Primary Biliary Cirrhosis	0.5	0.8	1.9	0.6	-0.6	1.2	-0.7	-1.4
Rheumatoid Arthritis	0.5	0.7	2.4	-1.0	-1.6	0.5	-0.5	-0.3
Cardiovascular Disease	0.5	1.8	3.4	1.6	1.8	1.0	1.2	1.6
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.5	-1.6	-1.1	0.4	-1.2	-0.5
Average weekly spirits intake	0.5	0.6	1.6	0.9	1.3	0.8	0.6	0.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.1	0.1	-1.5	0.9	-0.1	0.6
Relative age voice broke	0.5	0.8	2.9	-0.9	-0.5	-1.7	-0.1	-0.9
Serious illness, injury or assault to yourself	0.5	0.5	2.2	-0.5	-1.5	0.0	-0.6	-0.6
Impedance of leg (left)	0.5	2.5	4.6	-2.1	-1.3	-1.1	-2.0	-1.9
Financial difficulties in last 2 years	0.5	0.6	2.2	-0.5	-0.4	-0.2	-1.5	-1.0
Fluid intelligence score	0.5	1.1	1.8	1.2	1.1	1.0	1.2	1.3
Time employed in main current job	0.5	0.6	2.2	-0.1	1.0	-1.5	-0.2	0.5
Father’s age at death	0.5	0.7	1.8	-1.0	-0.6	-1.4	-0.9	-0.2
Depression (self-reported)	0.5	0.6	2.5	1.6	0.6	-0.7	0.1	0.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.8	-0.1	1.3	-1.4	-0.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.0	1.7	1.1	0.3	1.0	0.8
Pulse wave peak to peak time	0.5	0.6	1.5	1.2	0.6	1.0	0.6	0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.7	2.4	1.2	0.2	1.6	-0.1	-0.1
Migraine (self-reported)	0.5	0.6	2.7	-0.3	-0.9	1.6	0.1	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.2	-0.6	-0.4	1.5	-0.4	-0.7
Eye problems/disorders: Cataract	0.5	0.6	1.6	1.3	-0.6	0.8	0.8	0.6
Medication: Gliclazide	0.5	0.6	1.7	-1.3	-0.7	0.5	-0.9	-0.3
Ever taken oral contraceptive pill	0.5	0.6	1.4	0.8	0.1	0.8	1.2	0.9
Mother’s age at death	0.5	0.6	2.9	0.2	0.6	-1.7	0.2	0.4
Medication: Blood pressure	0.5	1.0	2.9	1.4	1.7	0.7	0.5	0.7
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	-1.0	-1.2	-0.3	-0.3	-1.0
Alcohol drinker status: Previous	0.5	0.6	1.4	0.3	0.4	1.2	0.8	1.1
Crohns Disease (2012)	0.4	0.7	2.1	0.1	-1.4	1.4	0.0	0.0
Neuroticism (2016)	0.4	0.6	1.6	0.9	-0.2	-0.7	-0.7	-1.2
Ulcerative Colitis	0.4	0.5	2.0	0.2	0.7	1.4	-0.5	-0.6
Blood Red Count	0.4	4.2	21.3	-0.1	1.3	-4.6	0.1	1.6
Height	0.4	7.8	33.5	-1.9	-2.6	5.8	-0.4	-1.6
Number of treatments/medications taken	0.4	0.7	3.1	1.8	0.2	0.7	0.5	0.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.3	1.1	0.6	-0.2	-0.8	-1.0
Hearing difficulty/problems: Yes	0.4	0.7	2.9	-0.4	-0.3	-1.7	0.6	0.6
Impedance of leg (right)	0.4	1.8	3.3	-1.8	-0.9	-0.9	-1.8	-1.6
Taking other prescription medications	0.4	0.6	1.5	-0.1	-0.7	-0.9	-1.2	-1.1
Medication: Levothyroxine sodium	0.4	0.7	3.2	1.8	0.9	-0.2	0.4	0.3
Heart attack	0.4	0.6	1.7	1.1	0.3	1.3	0.5	0.5
Trunk fat-free mass	0.4	2.5	11.2	-0.5	-1.7	3.3	0.4	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.3	0.6	0.4	-1.1	1.0	1.1
Medication: Lansoprazole	0.4	0.4	1.5	0.1	1.2	-0.6	0.5	0.8
Pulse wave Arterial Stiffness index	0.4	0.5	1.6	-1.3	-0.8	-0.6	-0.5	-0.4
Trunk predicted mass	0.4	2.5	11.3	-0.5	-1.8	3.4	0.4	-0.5
Medication: Paracetamol	0.4	0.6	2.2	-0.0	-1.5	-0.8	-0.7	-0.5
Supplements: Vitamin C	0.4	0.5	1.5	0.0	-1.2	0.9	0.8	-0.2
Osteoarthritis (self-reported)	0.4	0.5	3.0	0.3	-0.4	-1.7	0.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.4	-1.1	0.2	-1.8	-0.7	0.5
Number of operations (self-reported)	0.4	0.6	1.1	-0.7	-1.1	-0.5	-0.9	-1.0
Average weekly beer plus cider intake	0.4	0.6	1.7	1.3	-0.8	0.9	0.4	-0.1
Pain experienced in last month	0.4	0.6	2.2	0.1	0.6	1.5	0.3	1.0
Breast Cancer	0.3	0.6	2.5	-0.2	1.0	1.6	0.1	0.3
Lupus	0.3	0.5	1.5	1.1	0.4	1.2	0.0	0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.5	-0.2	-1.2	-0.9	0.0	0.0
Diabetes (mother)	0.3	0.4	1.2	-0.3	-1.1	-0.3	-0.8	-0.7
Leg fat-free mass (left)	0.3	1.4	7.3	0.4	-0.4	2.7	0.8	0.6
Fed-up feelings	0.3	0.5	1.5	0.1	-0.7	-0.4	-0.8	-1.2
Chronic bronchitis/emphysema (father)	0.3	0.3	1.4	-0.1	-1.2	0.4	-0.5	-0.3
High blood pressure (mother)	0.3	0.4	1.8	1.4	0.2	-0.3	0.6	0.4
Leg predicted mass (left)	0.3	1.4	7.3	0.4	-0.4	2.7	0.8	0.6
Waist circumference	0.3	1.2	2.6	-1.6	-1.3	1.6	-0.6	0.1
Number of incorrect matches in round	0.3	0.6	2.3	0.1	-1.0	1.5	0.2	0.0
Medication: Simvastatin	0.3	0.4	1.5	-0.0	-0.0	1.2	0.6	0.8
Falls in the last year	0.3	0.4	1.0	0.8	-0.2	0.4	-1.0	-0.8
Impedance of arm (left)	0.3	1.3	6.5	-0.3	2.5	-0.0	0.5	0.9
Standing height	0.3	3.1	17.2	-0.7	-0.8	4.2	0.6	-0.5
Hair/balding pattern: Pattern 4	0.3	0.8	3.0	0.5	-1.7	1.1	-0.3	0.0
Peak expiratory flow (PEF)	0.3	0.7	1.9	0.2	0.2	1.4	1.4	0.4
Pulse wave reflection index	0.3	0.3	1.2	-0.0	1.1	0.2	0.6	0.7
Birth weight	0.3	0.7	1.5	-0.5	-1.2	0.1	-1.1	-1.2
High blood pressure (siblings)	0.3	0.4	1.8	0.6	0.4	-0.2	0.3	1.3
Arm fat-free mass (right)	0.3	1.4	5.5	-0.2	-1.6	2.4	0.0	-0.5
Angina (self-reported)	0.3	0.3	1.2	0.3	0.8	-0.1	-0.0	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.1	1.0	-1.0	0.3	0.2	-0.4
Arm predicted mass (right)	0.3	1.5	6.4	-0.2	-1.5	2.5	-0.0	-0.5
Number of full sisters	0.3	0.3	1.3	-1.1	-0.4	-0.5	-0.1	0.5
Chest pain or discomfort	0.3	0.4	1.3	1.1	0.5	-0.7	-0.5	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.4	-0.5	1.2	-0.2	-0.4	-0.3
Whole body fat-free mass	0.3	1.9	9.2	-0.2	-1.3	3.0	0.4	-0.2
Leg fat-free mass (right)	0.3	1.6	7.9	0.4	-0.5	2.8	0.9	0.5
Mood swings	0.3	0.5	1.8	1.3	-0.3	0.0	0.1	-1.2
Loneliness, isolation	0.3	0.4	1.2	0.9	1.1	0.0	-0.4	-0.4
Diabetes diagnosed by doctor	0.3	0.4	1.9	-0.7	-0.3	1.4	-0.3	0.2
Whole body water mass	0.3	1.8	9.0	-0.2	-1.3	3.0	0.4	-0.2
Leg predicted mass (right)	0.3	1.6	7.9	0.4	-0.4	2.8	1.0	0.6
Miserableness	0.3	0.5	1.7	0.4	1.1	-1.3	-0.0	0.0
Hearing aid user	0.3	0.3	1.2	0.1	-0.3	-0.7	0.3	1.1
Basal metabolic rate	0.3	1.7	8.5	-0.2	-1.2	2.9	0.4	0.0
Leg fat percentage (left)	0.3	1.0	2.1	-1.4	-1.0	-0.8	-1.4	-0.3
Arm fat-free mass (left)	0.3	1.6	5.3	-0.5	-1.9	2.3	0.0	-0.6
Fractured/broken bones in last 5 years	0.3	0.4	1.3	-1.1	-0.1	0.3	-0.4	-0.8
Myopia	0.3	0.5	1.7	0.8	-1.3	-0.8	0.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	1.0	0.1	1.1	0.2	0.3
Arm predicted mass (left)	0.3	1.6	5.3	-0.4	-2.0	2.3	0.2	-0.4
Age at First Birth	0.2	0.3	0.8	0.4	0.9	0.7	0.0	0.0
Bipolar Disorder (2011)	0.2	0.2	0.8	0.2	0.4	-0.9	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	0.8	-0.7	0.4	0.0	0.0
Coronary Artery Disease (CAD)	0.2	0.2	1.1	-1.1	0.4	0.4	0.0	0.0
LDL Cholesterol	0.2	0.2	1.4	-0.0	-1.2	0.3	0.0	0.0
Blood Platelet Count	0.2	2.3	13.2	-0.3	0.0	3.6	0.4	-0.3
Heel T-Score	0.2	2.0	6.4	-0.1	0.2	-2.5	0.5	2.3
Chronotype (morning person)	0.2	0.5	1.4	1.2	1.0	0.8	0.1	0.5
Angina	0.2	0.3	1.2	0.3	0.8	-0.1	0.3	1.1
Medication: Co-codamol	0.2	0.2	0.4	0.6	-0.3	0.4	-0.3	-0.6
Average weekly fortified wine intake	0.2	0.3	1.3	-1.1	-0.1	-0.3	-0.5	-0.0
Stomach or abdominal pain in last month	0.2	0.2	0.5	0.1	-0.7	-0.3	0.5	0.7
Supplements: Glucosamine	0.2	0.3	0.7	-0.8	-0.1	-0.7	0.8	0.2
Sitting height	0.2	1.6	8.9	0.4	0.5	3.0	0.5	0.5
Mouth/teeth dental problems	0.2	0.3	1.0	0.4	0.2	1.0	0.6	0.2
Weight	0.2	0.8	3.5	-0.6	-1.1	1.9	-0.2	0.1
Hip circumference	0.2	1.0	3.8	0.2	0.3	1.9	0.8	1.3
Alcohol intake versus 10 years previously	0.2	0.3	1.2	0.3	-0.4	-1.1	-0.2	-0.1
Mouth/teeth dental problems: Dentures	0.2	0.4	1.5	0.1	-1.2	-0.4	-0.5	-0.6
Tense / ‘highly strung’	0.2	0.3	1.5	1.2	0.7	0.2	0.1	-0.3
Gout (self-reported)	0.2	0.3	0.7	0.2	-0.3	-0.8	-0.5	-0.8
Leg fat percentage (right)	0.2	0.6	1.4	-1.2	-0.8	-0.6	-1.2	0.0
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.7	0.6	-0.7	0.2	0.1
Family relationship satisfaction	0.2	0.2	1.2	1.1	-0.1	0.3	-0.1	0.1
Illnesses of father: Heart disease	0.2	0.3	1.1	0.2	1.0	-0.4	0.5	0.4
Ever had bowel cancer screening	0.2	0.3	1.1	1.1	-0.4	-0.3	0.0	-0.4
Medication for cholesterol	0.2	0.4	1.0	0.6	0.2	0.7	0.6	1.0
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	0.9	0.2	-0.3	-0.6	-0.8
Medication: Paracetamol	0.2	0.3	1.1	0.1	-1.0	-0.6	-0.5	-0.0
Medication: Atorvastatin	0.2	0.2	0.7	-0.6	-0.1	-0.8	-0.3	-0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.8	0.0	-0.8	-0.3	0.0
Diastolic blood pressure, automated reading	0.2	0.5	1.6	1.1	1.2	0.5	0.4	0.1
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.6	-0.7	-0.7	-0.4	-0.3
Bipolar Disorder (2018)	0.1	0.2	0.8	0.7	-0.3	-0.9	0.0	0.0
Ovarian Cancer	0.1	0.2	0.8	0.9	-0.1	-0.2	0.1	-0.6
Prostate Cancer	0.1	0.2	0.5	-0.7	-0.6	-0.4	0.0	0.0
Triglycerides	0.1	0.1	0.5	0.2	-0.7	-0.5	0.0	0.0
Lung FEV1/FVC ratio	0.1	0.6	2.6	-0.5	-1.6	0.7	-0.0	0.1
Hair Pigment	0.1	2.2	8.1	0.6	-1.5	2.8	-1.1	-1.1
Sensitivity / hurt feelings	0.1	0.2	0.8	0.3	-0.9	-0.4	-0.1	-0.5
Relative age of first facial hair	0.1	0.3	1.0	-0.8	0.0	-0.4	0.2	-1.0
Trunk fat percentage	0.1	0.3	0.9	-1.0	0.1	-0.2	-0.6	0.7
Townsend deprivation index at recruitment	0.1	0.2	0.5	-0.1	-0.7	0.5	-0.6	-0.3
Age when periods started (menarche)	0.1	0.1	0.5	0.4	-0.3	0.7	0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.4	0.6	0.4	-0.4	-0.4	-0.3
Trunk fat mass	0.1	0.4	0.9	-0.9	-0.4	0.8	-0.4	0.5
Had menopause	0.1	0.2	0.3	-0.4	0.6	-0.5	-0.5	-0.1
Forced vital capacity (FVC)	0.1	0.5	1.7	-1.3	0.0	-0.4	-0.5	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.9	-0.2	0.8	-0.9	-0.2	-0.5
Impedance of arm (right)	0.1	0.6	2.5	-0.6	1.6	0.1	0.5	0.7
Arm fat percentage (right)	0.1	0.2	1.0	-0.7	0.2	-0.1	-0.2	1.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.5	-1.2	0.1	-0.2	0.1	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.5	-1.2	0.5	-0.0	0.1	-0.1
Arm fat mass (right)	0.1	0.4	0.6	-0.8	-0.8	0.7	-0.4	0.6
Headache pain in last month	0.1	0.2	0.9	-0.0	-0.9	0.1	-0.1	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.5	1.9	-1.4	0.5	0.2	-0.4	-0.7
Body fat percentage	0.1	0.5	1.5	-1.2	-0.2	-0.4	-0.9	0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.7	-0.3	0.1	0.9	0.4	-0.3
Medication: Allopurinol	0.1	0.1	0.5	0.7	0.1	-0.3	-0.0	-0.3
Whole body fat mass	0.1	0.4	1.2	-1.1	-0.6	0.6	-0.7	0.4
Leg fat mass (right)	0.1	0.3	0.6	-0.6	-0.8	0.6	-0.8	0.3
Alcohol intake frequency.	0.1	0.3	0.7	0.8	0.1	0.2	0.8	0.7
Suffer from ‘nerves’	0.1	0.2	0.6	0.5	-0.3	-0.8	0.0	-0.2
Smoking status: Previous	0.1	0.2	1.0	-0.1	0.5	1.0	0.1	-0.2
Arm fat percentage (left)	0.1	0.4	1.4	-0.6	0.6	-0.1	-0.1	1.2
Friendships satisfaction	0.1	0.1	0.5	0.4	0.2	-0.7	0.0	0.0
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	-0.6	0.2	-0.5	-0.3	-0.2
Arm fat mass (left)	0.1	0.3	0.8	-0.7	-0.2	0.7	-0.1	0.9
Wears glasses or contact lenses	0.1	0.2	0.6	0.2	-0.8	-0.5	0.2	-0.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.2	-0.5	-0.0	-0.3	0.0
Supplements: Calcium	0.1	0.1	0.8	0.2	0.0	0.9	0.1	-0.1
Impedance of whole body	0.1	0.5	1.3	-1.1	0.8	-0.7	-0.5	-0.3
Leg fat mass (left)	0.1	0.5	1.2	-0.8	-1.1	0.5	-0.9	0.0
HDL Cholesterol	0.0	0.0	0.1	0.1	0.4	0.1	0.0	0.0
BMI	0.0	0.2	0.5	0.6	-0.5	0.3	0.1	0.7
Tanning	0.0	0.4	1.0	0.1	-0.8	1.0	0.6	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.4	0.5	-0.3	0.2	-0.2
Body mass index (BMI)	0.0	0.2	0.6	-0.4	-0.8	0.0	-0.6	0.3
Osteoporosis (self-reported)	0.0	0.1	0.3	0.0	0.1	0.2	0.5	0.1
High cholesterol (Self-reported)	0.0	0.1	0.2	-0.2	0.2	-0.4	-0.3	-0.1

Hub : Genes

SNHG12

Models

Trait associations