[Hub]/) : Traits : Pulse rate, automated reading :

chr1:39,258,674-40,737,589

Best TWAS P=1.84e-11 · Best GWAS P=5.75e-09 conditioned to 0.235

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex BMP8A 0.05 0.03 lasso 3 0.02 8.8e-04 5.6 5.7 1.1e-08 0.98 0.02 0.96 FALSE
2 GTEx Adipose Subcutaneous BMP8A 0.06 0.05 lasso 1 0.04 3.5e-04 5.6 5.6 1.8e-08 0.70 0.02 0.88 FALSE
3 GTEx Adrenal Gland PABPC4 0.20 0.09 lasso 8 0.06 3.0e-03 5.8 -6.4 1.8e-10 -0.95 0.02 0.91 FALSE
4 GTEx Adrenal Gland RP11-69E11.4 0.11 0.05 lasso 3 0.00 2.4e-01 5.6 5.9 2.8e-09 0.76 0.03 0.72 FALSE
5 GTEx Artery Aorta RP11-69E11.4 0.13 0.10 enet 14 0.14 2.5e-08 5.6 5.2 2.0e-07 0.86 0.02 0.98 FALSE
6 GTEx Artery Tibial PABPC4 0.10 0.10 lasso 4 0.10 3.4e-08 5.8 -5.9 3.2e-09 -0.99 0.00 1.00 FALSE
7 GTEx Artery Tibial RP11-69E11.4 0.15 0.16 lasso 6 0.16 8.3e-13 5.5 5.5 3.3e-08 0.76 0.03 0.97 FALSE
8 GTEx Brain Cerebellar Hemisphere RP11-69E11.4 0.22 0.08 enet 16 0.08 4.5e-03 5.5 5.2 2.4e-07 0.71 0.09 0.77 FALSE
9 GTEx Brain Frontal Cortex BA9 RP11-69E11.4 0.23 0.10 lasso 6 0.11 7.2e-04 5.5 5.8 9.1e-09 0.71 0.04 0.77 FALSE
10 GTEx Breast Mammary Tissue PABPC4 0.13 0.02 enet 14 0.04 3.4e-03 5.6 -5.4 7.6e-08 -0.93 0.02 0.95 FALSE
11 GTEx Breast Mammary Tissue RP11-69E11.4 0.15 0.05 enet 32 0.05 8.8e-04 4.9 6.3 2.6e-10 0.63 0.14 0.83 FALSE
12 GTEx Cells Transformed fibroblasts PABPC4 0.07 0.09 lasso 1 0.06 2.7e-05 5.8 -5.8 5.8e-09 -1.00 0.01 0.99 FALSE
13 GTEx Colon Sigmoid RP11-69E11.4 0.20 0.16 lasso 5 0.20 1.1e-07 4.8 5.4 6.2e-08 0.78 0.17 0.81 FALSE
14 GTEx Colon Transverse RP11-69E11.4 0.23 0.12 lasso 4 0.15 1.8e-07 5.6 5.7 1.4e-08 0.89 0.02 0.98 FALSE
15 GTEx Esophagus Mucosa PABPC4 0.06 0.06 lasso 3 0.08 7.3e-06 5.6 -5.9 3.0e-09 -0.98 0.01 0.99 FALSE
16 GTEx Esophagus Mucosa RP11-69E11.4 0.18 0.06 lasso 9 0.07 2.2e-05 5.5 6.0 2.0e-09 0.77 0.06 0.94 FALSE
17 GTEx Esophagus Muscularis BMP8A 0.08 0.05 enet 10 0.05 3.5e-04 4.1 5.2 2.0e-07 0.77 0.12 0.84 FALSE
18 GTEx Heart Left Ventricle RP11-69E11.4 0.10 0.10 lasso 4 0.08 3.8e-05 5.5 5.4 8.0e-08 0.69 0.05 0.92 FALSE
19 GTEx Lung PABPC4 0.05 0.03 lasso 3 0.02 1.3e-02 5.8 -5.7 1.4e-08 -0.96 0.02 0.95 FALSE
20 GTEx Nerve Tibial PABPC4 0.17 0.08 enet 12 0.05 2.7e-04 5.8 -5.2 2.3e-07 -0.85 0.01 0.99 FALSE
21 GTEx Nerve Tibial RP11-69E11.4 0.18 0.08 lasso 5 0.18 1.3e-12 4.7 5.9 4.6e-09 0.88 0.03 0.97 FALSE
22 GTEx Nerve Tibial RP11-69E11.8 0.05 0.00 lasso 3 0.01 6.9e-02 5.8 -6.0 1.7e-09 -0.99 0.02 0.90 FALSE
23 GTEx Skin Not Sun Exposed Suprapubic PABPC4 0.12 0.10 lasso 3 0.05 1.0e-03 5.6 -5.8 7.4e-09 -0.97 0.01 0.98 FALSE
24 GTEx Skin Sun Exposed Lower leg PABPC4 0.11 0.09 lasso 7 0.08 2.7e-07 5.6 -5.7 1.2e-08 -0.96 0.01 0.99 FALSE
25 GTEx Skin Sun Exposed Lower leg RP11-69E11.4 0.13 0.12 lasso 6 0.15 1.3e-12 4.9 5.9 3.6e-09 0.75 0.17 0.83 FALSE
26 GTEx Spleen RP11-69E11.4 0.25 0.12 lasso 4 0.15 9.3e-05 5.5 5.8 6.7e-09 0.73 0.08 0.83 FALSE
27 GTEx Stomach RP11-69E11.4 0.31 0.20 lasso 4 0.20 4.0e-10 5.5 5.4 7.3e-08 0.74 0.03 0.97 FALSE
28 GTEx Thyroid RP11-69E11.4 0.17 0.04 lasso 9 0.06 4.4e-05 5.5 5.4 5.6e-08 0.81 0.02 0.95 FALSE
29 METSIM Adipose PABPC4 0.05 0.02 lasso 6 0.03 6.0e-05 5.6 -5.5 4.3e-08 -0.89 0.02 0.98 FALSE
30 NTR Blood PABPC4 0.01 0.00 blup 383 0.00 2.8e-02 5.8 -5.7 1.5e-08 -0.73 0.02 0.82 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma BMP8A 0.05 0.01 lasso 6 0.02 5.5e-05 5.6 5.8 6.6e-09 0.81 0.00 0.99 FALSE
32 The Cancer Genome Atlas Breast Invasive Carcinoma PABPC4 0.03 0.03 lasso 2 0.04 1.3e-08 5.8 -5.8 5.1e-09 -0.92 0.00 1.00 FALSE
33 The Cancer Genome Atlas Esophageal Carcinoma BMP8A 0.15 0.08 blup 41 0.10 4.0e-04 4.1 5.2 1.8e-07 0.59 0.05 0.77 FALSE
34 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma BMP8A 0.04 0.03 blup 48 0.04 3.5e-05 5.5 6.7 1.8e-11 0.75 0.01 0.98 TRUE
35 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PABPC4 0.03 0.01 enet 4 0.02 4.3e-03 5.8 -5.5 4.0e-08 -0.98 0.00 0.98 FALSE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PABPC4 0.04 0.05 blup 31 0.04 1.2e-05 5.5 -5.8 4.9e-09 -0.84 0.01 0.99 FALSE
37 The Cancer Genome Atlas Lung Adenocarcinoma PABPC4 0.04 0.03 enet 8 0.04 4.5e-05 5.6 -5.7 1.3e-08 -0.93 0.00 0.99 FALSE
38 The Cancer Genome Atlas Prostate Adenocarcinoma BMP8A 0.07 0.06 enet 7 0.07 5.8e-08 4.1 5.3 1.2e-07 0.67 0.04 0.96 FALSE
39 The Cancer Genome Atlas Prostate Adenocarcinoma PPIEL 0.04 0.02 lasso 4 0.02 1.7e-03 5.5 5.8 7.3e-09 0.74 0.02 0.80 FALSE
40 The Cancer Genome Atlas Thyroid Carcinoma PABPC4 0.09 0.07 enet 5 0.08 4.1e-08 5.8 -5.8 6.3e-09 -0.87 0.00 1.00 FALSE