Hub : Genes

CPNE5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.1540 0.0520 2.1e-03 0.012 NA 0.028 NA 0.032 7.5e-02 NA 1.3e-02 NA 8.8e-03
2 GTEx Brain Cerebellum 0.2280 0.0820 6.0e-03 -0.007 NA 0.003 NA -0.010 5.9e-01 NA 2.6e-01 NA 9.1e-01
3 GTEx Nerve Tibial 0.2025 0.0494 1.1e-05 0.177 NA 0.152 NA 0.129 1.3e-12 NA 6.5e-11 NA 2.3e-09
4 ROSMAP Brain Pre-frontal Cortex 0.0524 0.0222 5.3e-03 -0.001 0.018 0.000 0.017 0.000 4.2e-01 1.9e-03 3.6e-01 2.5e-03 3.2e-01
5 YFS Blood 0.0595 0.0131 5.8e-14 0.044 0.048 0.056 0.053 0.052 3.4e-14 2.6e-15 1.0e-17 6.8e-17 1.2e-16
6 TCGA Prostate Adenocarcinoma 0.0493 0.0215 4.0e-03 0.007 0.031 0.009 NA 0.017 5.0e-02 3.4e-04 3.6e-02 NA 6.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.0 1.5 7.1 -2.7 0.1 0.4 1.0 -0.8 -0.4
Bipolar Disorder or Schizophrenia 0.3 0.6 1.5 -1.2 0.4 0.4 1.1 -0.2 -0.8
Depressed Affect (Nagel 2018) 1.5 3.1 9.4 1.8 -0.8 2.0 -3.1 0.8 1.0
Depression (Nagel 2018) 1.7 2.6 6.2 1.1 -2.5 -0.1 -1.5 0.9 -2.2
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.5 -1.2 0.4 0.1 -0.6 -1.1 0.6
Neuroticism (Nagel 2018) 2.1 4.8 14.5 2.3 -2.1 2.0 -3.8 1.0 -0.1
Schizophrenia (2018) 0.1 0.3 0.4 0.6 0.5 0.2 0.6 0.4 -0.7
Schizophrenia vs Biploar Disorder 0.7 0.9 1.8 1.3 0.2 1.3 -1.0 -0.0 0.9
Worry (Nagel 2018) 1.1 2.3 6.5 0.8 -2.3 0.2 -2.5 -0.3 -1.0
Alzheimer’s Disease (in mother) 0.1 0.1 0.4 -0.6 -0.5 0.4 0.1 0.0 -0.2
Alzheimer’s Disease (in father) 0.9 1.0 2.6 -1.0 1.1 -0.1 1.0 -0.4 1.6
Alzheimer’s Disease (including proxy) 0.3 0.5 1.5 -1.2 0.5 0.3 0.6 -0.3 0.7
Crohns Disease (2017) 1.6 3.4 7.1 -2.3 -2.4 -1.5 0.6 -0.0 -2.7
Irritable Bowel Disease (IBD) 0.8 1.8 4.6 -1.2 -2.1 -0.4 0.6 0.6 -2.0
Ulcerative Colitis (UC) 0.2 0.4 0.8 0.3 -0.9 0.8 0.4 0.8 -0.5
Major Depression (MDD) 0.5 0.6 1.9 -0.6 -1.1 -0.1 -0.5 -0.3 -1.4
Reaction Time 0.2 0.4 1.2 0.5 0.1 0.8 -0.0 0.4 1.1
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.5 -0.7 -0.4 0.3 -0.6 -0.1 -0.4
Breast Cancer 1.3 3.1 9.4 -1.5 2.6 -0.3 3.1 0.3 0.7
Ovarian Cancer 0.5 0.6 1.5 -0.0 -0.9 -1.1 -0.1 -0.1 -1.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.0 1.4 2.4 -0.6 1.2 -0.6 1.4 1.4 1.5
Bipolar Disorder (2011) 0.3 0.3 0.8 -0.9 -0.2 -0.1 0.5 0.1 -0.8
Body Mass Index (BMI) (2010) 0.5 0.7 2.5 -1.6 0.0 0.7 0.4 -0.9 -0.1
Coronary Artery Disease (CAD) 2.1 2.5 8.3 2.9 0.4 -1.3 1.5 1.5 0.5
Crohns Disease (2012) 1.7 2.7 4.1 -2.0 -1.1 -2.0 1.8 0.3 -1.9
Mean Putamen Volume 0.4 0.4 1.1 -1.1 0.5 -0.3 0.9 0.1 -0.4
Fasting Glucose 1.0 1.2 4.2 0.4 0.0 1.4 -2.1 -0.0 0.9
HbA1C 1.3 1.5 6.8 -0.0 0.6 2.6 -0.2 1.1 0.6
HDL Cholesterol 0.7 1.2 4.8 0.6 1.4 -0.0 0.3 -0.5 2.2
LDL Cholesterol 0.0 0.1 0.1 -0.3 0.3 0.2 0.3 -0.2 0.2
Lupus 1.4 2.1 3.8 -0.9 1.9 1.9 1.1 -0.2 1.8
Neuroticism (2016) 1.6 2.3 5.1 1.5 -1.5 1.4 -2.3 1.4 -0.4
Primary Biliary Cirrhosis 0.7 1.0 1.7 -0.4 0.6 1.3 1.2 1.3 0.7
Rheumatoid Arthritis 0.2 0.2 0.5 0.3 0.6 -0.4 -0.1 0.7 0.3
Schizophrenia (2014) 0.3 0.7 2.4 -0.0 0.9 1.5 -0.6 -0.1 0.6
Triglycerides 0.3 0.6 1.6 -0.9 -0.2 0.5 -0.0 -0.9 -1.2
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.1 -1.4 -1.1 -1.4 -0.1 -0.1 -0.3
Ulcerative Colitis 0.7 0.9 2.1 -0.5 -1.5 0.4 0.8 1.3 -0.9
Blood Eosinophil Count 0.1 0.5 1.3 0.1 -1.1 -1.1 -0.4 0.1 0.8
Blood Platelet Count 0.1 1.0 2.5 -0.1 -0.3 0.1 -1.6 -1.6 -1.0
Blood Red Count 0.1 0.8 3.9 -2.0 -0.2 -0.2 0.7 -0.5 0.1
Blood White Count 0.7 5.0 15.2 -3.9 -1.0 0.2 3.5 0.9 -0.5
Heel T-Score 1.2 9.5 20.6 3.0 2.5 4.5 -3.0 0.7 3.5
BMI 0.3 1.6 4.2 -2.1 -1.1 0.2 -0.6 -1.2 -1.5
Height 0.5 9.2 19.4 -2.3 -4.4 -2.8 2.9 -1.4 -3.4
Waist Hip Ratio (WHR) 0.3 1.3 5.2 0.8 0.8 -0.3 1.0 0.4 2.3
Systolic Blood Pressure 0.6 3.1 10.6 -0.6 -0.2 -2.7 3.3 0.8 -0.3
Smoking Status 0.5 1.2 3.7 1.4 -0.4 1.0 -0.6 1.9 0.5
Allergy or Eczema 0.2 0.5 1.4 -0.0 1.0 0.0 -1.2 -0.6 0.6
Cardiovascular Disease 0.1 0.3 1.0 0.5 0.1 -0.2 -0.5 -0.3 1.0
Hypothyroidism (self reported) 0.6 1.3 3.4 -1.8 0.8 1.4 0.4 -1.0 0.7
Respiratory disease 0.4 0.9 2.0 -0.8 -1.1 -1.4 -0.7 -0.9 -0.6
Type 2 Diabetes (T2D) (2018) 0.1 0.3 0.6 0.8 -0.7 0.0 -0.4 -0.3 0.6
Lung FEV1/FVC ratio 0.1 0.7 2.3 -0.6 0.9 -0.4 1.5 0.3 0.6
Lung FVC 0.5 2.6 7.0 1.7 -0.5 2.3 -2.6 0.2 0.0
Neuroticism 1.5 3.6 11.4 2.1 -0.9 2.1 -3.4 0.0 0.2
Chronotype (morning person) 0.3 0.7 2.6 -0.1 -1.6 -0.9 0.3 -0.4 -0.8
Hair Pigment 0.1 1.8 10.2 0.8 -0.1 0.3 0.2 3.2 -0.1
Tanning 0.1 1.2 2.8 -0.1 1.4 1.1 0.6 -1.7 1.0
Hand grip strength (left) 0.3 0.7 2.3 -0.8 -0.7 1.5 -0.7 -0.7 0.0
Number of treatments/medications taken 1.5 2.6 6.5 2.3 -1.6 -0.8 -2.5 0.4 -0.6
Average weekly spirits intake 0.6 0.7 1.7 0.7 -0.6 0.8 -1.3 -0.8 -0.6
Sensitivity / hurt feelings 3.3 5.6 14.1 2.7 0.8 3.8 -1.9 2.2 1.7
Frequency of depressed mood in last 2 weeks 1.2 1.6 3.7 0.8 -1.9 0.4 -0.6 1.2 -1.9
Hearing difficulty/problems: Yes 1.5 2.3 6.1 -0.6 -1.7 -2.1 -0.2 0.4 -2.5
Relative age of first facial hair 0.4 0.9 1.6 -0.8 -0.4 -1.3 0.9 -1.3 -0.8
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 -0.2 -0.3 -0.3 -0.3 -0.1 -0.4
Ever used hormone-replacement therapy (HRT) 1.2 1.5 5.8 2.4 0.0 -0.7 -1.0 1.0 0.9
Ever had hysterectomy (womb removed) 0.9 1.0 2.6 1.2 0.6 -0.8 -0.5 1.6 0.6
Systolic blood pressure, automated reading 0.8 2.5 9.5 -0.9 -1.2 -3.1 1.5 0.0 -0.8
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.9 -0.5 -0.6 1.1 0.4 1.7 -0.8
Angina 1.5 2.0 4.5 1.1 1.3 -0.3 1.6 1.3 2.1
Medication for hormone replacement therapy 1.5 1.7 4.9 2.2 0.3 -1.5 -1.0 1.3 0.7
Vitamin and mineral supplements 1.1 1.5 4.7 -2.2 -0.5 0.6 1.6 -1.1 0.2
Supplements: Zinc 1.2 1.3 3.8 2.0 -0.9 -0.4 -1.4 0.8 0.5
Medication: Co-codamol 0.5 0.6 1.4 -0.4 0.7 -1.2 0.6 -1.0 0.1
Medication: Metformin 0.6 0.8 1.8 1.3 -0.7 0.3 -1.3 -0.5 0.6
Diabetes (father) 0.6 0.8 1.6 1.0 -0.8 0.8 0.4 1.3 -0.7
Diabetes (mother) 0.5 0.7 1.0 -0.8 -1.0 -0.8 1.0 -0.2 -0.9
Severe depression (siblings) 2.6 2.9 4.8 -1.4 -2.2 1.7 -1.9 -0.9 -1.8
Pack years adult smoking proportion 0.7 1.1 3.8 0.3 0.7 -1.9 -0.4 -1.3 0.4
Impedance of leg (right) 1.0 4.7 10.3 1.6 3.2 2.0 0.8 0.6 3.2
Leg fat-free mass (left) 1.2 6.3 14.5 -2.5 -3.5 -1.8 0.7 -0.8 -3.8
Trunk fat percentage 0.2 0.6 2.7 -0.5 -1.6 -0.1 -0.4 -0.1 -0.8
Hand grip strength (right) 0.2 0.6 2.4 -1.5 -0.5 0.5 0.0 -0.5 -0.5
Townsend deprivation index at recruitment 2.4 3.4 7.6 0.9 -2.6 0.5 0.4 2.8 -2.1
Current tobacco smoking 0.9 1.5 4.1 2.0 0.3 0.2 -0.3 2.0 0.9
Average weekly fortified wine intake 0.7 0.8 2.6 0.5 0.1 1.6 -1.1 0.0 -0.8
Maternal smoking around birth 1.7 2.5 5.7 2.4 0.7 0.6 -0.9 2.3 1.5
Fed-up feelings 0.9 1.7 4.5 -0.1 -1.4 1.8 -2.1 0.1 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 5.0 0.6 -2.2 0.1 -1.6 0.8 -1.9
Relative age voice broke 0.4 0.6 1.3 -0.4 -1.1 0.4 0.9 -0.4 -1.0
Taking other prescription medications 0.5 0.7 2.2 0.8 0.4 -0.7 -1.5 -0.7 0.6
Age when periods started (menarche) 0.3 0.8 1.5 -0.5 1.2 -0.6 1.0 -0.5 1.2
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 4.8 0.3 -0.0 -2.2 0.8 1.5 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.6 9.2 0.6 1.3 3.0 -1.3 -0.4 1.4
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 4.4 -0.3 2.1 -0.2 1.0 -1.3 1.2
Qualifications: CSEs or equivalent 0.5 0.6 2.0 0.6 -0.0 0.9 -1.4 0.1 0.6
Serious illness, injury or assault to yourself 0.8 1.0 3.0 -1.7 0.8 1.3 0.5 -0.5 -0.0
High blood pressure 0.3 0.8 3.9 2.0 0.3 -0.6 -0.7 0.3 0.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.0 -0.2 0.2 -0.2 -1.1 -1.4 0.2
Multivitamins +/- minerals 0.7 0.9 2.8 1.7 1.2 -0.4 -0.7 0.6 0.6
Stomach or abdominal pain in last month 0.5 0.6 1.5 0.7 1.2 -0.1 0.2 0.8 0.9
Supplements: Glucosamine 1.6 2.0 6.1 2.5 -0.2 -0.9 -1.5 1.5 0.9
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 4.5 -2.1 1.5 -0.3 0.5 -1.9 0.2
Medication: Atenolol 1.2 1.5 2.9 1.5 0.7 1.1 0.1 1.5 1.7
Medication: Levothyroxine sodium 0.7 1.2 3.9 -2.0 0.9 -0.1 1.1 -1.1 -0.1
Sitting height 0.5 3.6 5.8 -2.4 -2.0 -1.9 1.4 -1.6 -1.9
Chronic bronchitis/emphysema (father) 0.8 0.9 2.4 -1.6 0.0 0.0 1.2 -0.9 -0.7
High blood pressure (mother) 0.6 0.8 3.0 1.7 0.4 -1.2 -0.5 0.4 -0.1
Body mass index (BMI) 0.5 2.0 3.8 -1.4 -1.9 -1.1 -0.5 -1.0 -1.9
Impedance of leg (left) 0.7 3.3 7.1 2.0 2.5 1.6 -0.0 0.7 2.7
Leg predicted mass (left) 1.2 6.2 14.2 -2.4 -3.5 -1.8 0.7 -0.7 -3.8
Trunk fat mass 0.4 1.6 5.2 -1.2 -2.3 -0.7 -0.1 -0.4 -1.6
Waist circumference 0.3 1.1 3.1 -0.5 -1.8 -1.0 0.2 -0.5 -1.2
Number of incorrect matches in round 1.3 2.1 9.9 3.1 1.1 0.7 -0.6 0.1 0.9
Past tobacco smoking 0.4 0.6 1.3 -0.9 0.6 -0.9 0.7 -1.1 -0.2
Alcohol usually taken with meals 0.6 1.0 2.3 -0.5 -1.5 -1.1 -0.1 -1.4 -0.4
Nervous feelings 0.7 1.4 4.0 -0.1 -0.3 1.9 -2.0 -0.8 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 3.0 -0.5 -1.7 1.1 -1.7 -0.8 -0.9
Hearing difficulty/problems with background noise 0.5 0.7 1.7 -0.8 -0.8 -0.3 -1.3 -0.5 -1.1
Hair/balding pattern: Pattern 2 0.7 0.9 2.0 0.1 -1.4 -0.1 -1.4 -0.7 -0.9
Had menopause 1.0 1.3 3.5 1.9 -1.2 -0.4 -0.8 1.3 0.2
Had other major operations 0.3 0.4 1.8 0.6 -0.0 -1.3 -0.5 -0.1 -0.3
Forced vital capacity (FVC) 0.2 0.8 1.8 -1.0 -1.4 1.0 -0.6 -0.6 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 4.5 0.2 1.2 2.1 -0.8 -0.9 0.7
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 6.4 -0.8 -1.3 2.5 -0.5 0.4 -0.5
Qualifications: None of the above 0.1 0.2 0.4 0.4 -0.5 0.4 0.3 0.6 -0.4
Financial difficulties in last 2 years 1.0 1.3 2.7 1.2 0.3 1.6 -0.9 1.7 0.4
Mouth/teeth dental problems 0.7 1.1 3.4 -0.7 1.5 -0.7 1.8 -0.3 -0.1
Heart attack 0.5 0.6 1.6 -0.3 -0.1 -1.0 1.3 -0.6 -0.9
Allergy 0.4 0.9 2.9 0.5 0.7 0.6 1.1 1.7 0.3
Pain all over the body in last month 2.3 2.4 6.7 -0.2 2.6 0.6 0.9 -0.8 2.4
Diabetes (self-reported) 0.4 0.6 2.0 0.9 -0.6 0.3 -1.4 0.2 0.7
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 2.5 -0.1 -0.8 0.5 -1.6 0.5 -0.8
Medication: Ramipril 1.0 1.3 5.6 -0.4 0.3 -1.3 2.4 0.5 -0.4
Medication: Simvastatin 1.0 1.5 3.7 -1.4 -0.2 -1.5 1.0 -1.9 0.3
Fluid intelligence score 0.4 0.8 4.1 -2.0 -0.6 -0.5 0.2 -0.6 -0.2
Illnesses of siblings 0.2 0.3 1.6 0.1 -0.2 1.2 -0.1 0.2 0.0
Neuroticism score 1.2 2.5 7.7 1.2 -0.8 2.3 -2.8 -0.2 0.3
Weight 0.9 4.2 9.9 -1.8 -3.1 -1.7 0.1 -0.8 -3.0
Impedance of arm (right) 0.4 2.0 6.0 0.8 1.3 1.8 0.1 0.8 2.5
Arm fat percentage (right) 0.2 0.7 1.9 -1.4 -1.2 -0.2 -0.1 -0.7 -0.7
Trunk fat-free mass 1.2 6.6 14.7 -2.7 -3.2 -2.2 1.2 -1.1 -3.8
Hip circumference 0.7 2.9 5.9 -1.9 -2.1 -1.1 0.3 -1.4 -2.4
Time employed in main current job 0.5 0.6 2.0 -0.9 0.6 -0.5 0.2 -0.6 1.4
Alcohol intake versus 10 years previously 1.0 1.5 4.0 -1.8 -0.8 -0.7 2.0 0.8 -0.1
Father’s age at death 0.0 0.0 0.0 -0.2 0.1 0.0 0.2 -0.1 -0.2
Worrier / anxious feelings 0.8 1.5 3.9 0.2 -1.6 -0.0 -2.0 -0.9 -1.4
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.8 9.7 -0.1 -3.1 0.3 -1.8 0.6 -3.0
Falls in the last year 0.7 0.9 3.4 0.8 -0.5 -0.3 -1.8 -1.0 0.6
Hair/balding pattern: Pattern 3 1.0 1.5 4.6 -0.1 2.1 0.1 1.7 0.4 1.2
Number of live births 0.5 0.7 3.4 0.2 0.2 -1.9 0.8 -0.3 0.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.7 -1.3 -0.7 0.8 -0.0 -0.8 -0.1
Pulse rate 1.4 2.3 6.5 1.5 1.8 2.5 0.5 1.1 0.8
Happiness 1.8 2.2 6.7 1.4 0.3 1.8 -0.0 2.6 1.0
Noisy workplace 0.6 0.8 2.6 0.5 -0.1 1.6 -1.1 -0.1 0.6
Qualifications: A levels/AS levels or equivalent 0.3 0.7 2.4 0.7 0.0 1.6 0.3 1.2 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.4 -0.3 -0.2 0.6 -0.3 0.2 0.5
Mouth/teeth dental problems: Dentures 2.0 3.4 8.4 2.9 -1.7 0.2 -2.3 1.6 -0.8
Asthma 0.4 0.9 2.5 -0.1 -0.8 -1.0 -1.6 -1.0 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 3.5 1.1 -0.9 -0.5 -0.8 0.9 -1.9
Medication: Cholesterol lowering 0.5 0.8 2.1 -0.1 0.5 -0.1 0.8 -1.4 1.5
Depression (self-reported) 1.9 2.3 6.1 -0.3 -2.0 1.4 -2.5 -0.6 -1.3
Medication: Lansoprazole 2.0 2.3 5.6 0.5 2.4 1.2 -0.9 -0.5 2.4
Prospective memory result 1.2 1.4 3.1 -1.0 1.2 -0.3 1.6 -1.8 -0.6
Lung cancer (father) 0.5 0.6 1.2 1.0 -0.8 -0.6 -0.3 1.1 -0.7
Illnesses of mother 0.8 1.0 4.0 -2.0 -0.2 0.1 0.3 -1.2 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.7 -0.8 0.0 0.5 0.2 -0.7 0.7
Pulse wave Arterial Stiffness index 1.4 1.6 6.1 0.1 -0.8 1.6 -0.1 2.5 -0.7
Impedance of arm (left) 0.5 2.3 6.4 1.3 1.4 1.6 0.1 1.0 2.5
Arm fat mass (right) 0.4 1.8 3.7 -1.7 -1.9 -1.1 0.1 -1.0 -1.5
Trunk predicted mass 1.2 7.0 15.3 -2.8 -3.3 -2.2 1.3 -1.2 -3.9
Standing height 0.3 3.4 7.6 -1.2 -2.8 -1.5 1.7 -0.1 -2.5
Length of working week for main job 1.3 1.5 3.2 -1.2 -0.9 -0.1 -1.8 -1.8 -0.4
Exposure to tobacco smoke at home 0.2 0.3 0.9 0.1 -0.0 -0.1 -0.9 -0.9 -0.1
Breastfed as a baby 1.2 1.5 3.7 -1.9 1.3 -0.8 1.6 -0.4 -0.4
Tense / ‘highly strung’ 0.3 0.5 1.0 0.5 -0.8 0.7 -1.0 -0.8 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 4.8 -0.8 -1.1 2.2 -2.0 -0.8 0.5
Hair/balding pattern: Pattern 4 0.9 2.3 8.3 2.9 -1.1 0.7 -1.6 1.1 -0.2
Birth weight of first child 2.3 4.1 11.9 -2.2 -2.6 -0.3 -0.5 -1.0 -3.4
Peak expiratory flow (PEF) 0.5 1.0 3.7 0.2 0.7 0.0 0.1 -1.4 1.9
Pulse wave reflection index 2.1 2.6 5.3 0.2 -2.1 -0.7 -0.9 2.3 -2.0
Ever highly irritable/argumentative for 2 days 1.2 1.4 4.5 0.3 0.9 2.1 -1.2 1.1 0.6
Loud music exposure frequency 1.3 1.4 4.2 -0.4 0.8 2.0 -0.0 1.8 0.6
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 5.4 2.3 0.4 0.4 -1.2 0.8 1.0
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.2 -0.2 0.6 1.1 0.3 -0.4 0.8
Blood clot in the leg (DVT) 0.5 0.6 1.6 0.6 -0.7 -1.3 0.8 0.4 -0.6
Medication: Paracetamol 0.1 0.2 0.6 0.1 -0.4 -0.7 -0.7 -0.3 0.0
Headache pain in last month 0.4 0.7 3.2 0.2 -0.4 -0.2 -1.8 -1.0 -0.5
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.6 -0.2 0.3 0.7 0.3 0.8 -0.5
Glaucoma (self-reported) 1.0 1.2 2.6 1.3 -1.2 0.3 -1.6 0.1 -1.1
Gout (self-reported) 0.7 0.9 2.1 1.5 0.5 1.0 -0.6 0.6 1.2
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 1.8 -1.4 1.4 1.4 1.2 -0.1 0.9
Medication: Amlodipine 0.7 0.9 3.6 0.2 -0.2 -1.9 1.3 0.2 -0.4
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.1 1.0 -1.0 -0.9 -0.5 0.3 -0.7
Birth weight 0.4 0.8 1.8 -0.9 -1.3 0.1 -1.0 0.8 -0.7
Chronic bronchitis/emphysema (mother) 0.7 0.9 3.3 0.0 0.5 1.1 -0.3 -0.5 1.8
High blood pressure (siblings) 0.8 1.1 3.4 1.6 0.4 -1.8 -0.6 -0.4 -0.3
Forced vital capacity (FVC), Best measure 0.1 0.4 1.1 -0.6 -0.6 0.6 -0.5 -1.0 -0.0
Body fat percentage 0.1 0.5 1.8 -0.5 -1.3 -0.1 -0.3 -0.1 -0.8
Leg fat percentage (right) 0.1 0.3 0.8 -0.1 -0.7 0.0 -0.6 -0.1 -0.9
Arm fat-free mass (right) 1.0 5.3 13.2 -1.8 -3.0 -2.3 0.8 -0.7 -3.6
Exposure to tobacco smoke outside home 1.8 2.4 6.4 0.5 -1.5 2.1 -2.5 -1.1 -0.1
Comparative body size at age 10 1.0 2.8 8.5 0.8 1.8 0.6 -2.9 -0.7 1.8
Number of full brothers 0.8 1.0 3.5 -0.4 -1.3 -1.9 -0.5 -0.8 -0.2
Worry too long after embarrassment 0.7 1.2 2.5 1.2 -1.1 1.6 -1.4 -0.3 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.9 6.8 0.7 -0.8 2.6 -1.6 0.5 -0.7
Wheeze or whistling in the chest in last year 0.3 0.5 2.1 -0.3 -0.6 -1.4 -0.3 -0.1 0.6
Number of children fathered 0.7 0.7 1.5 -1.0 -0.3 -1.2 0.7 -1.1 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.2 1.1 1.2 1.5 -0.1 1.0 1.4
Age at first live birth 0.3 0.5 1.6 -0.2 0.8 -0.2 1.3 0.6 0.2
Pulse wave peak to peak time 1.6 1.8 6.4 -0.3 0.5 -2.0 0.3 -2.5 0.5
Health satisfaction 0.3 0.4 1.1 -0.2 -0.6 -0.1 -1.1 -0.8 0.2
Shortness of breath walking on level ground 0.2 0.2 0.7 -0.4 0.6 -0.8 0.2 -0.1 -0.2
Qualifications: College or University degree 0.6 1.9 6.2 -2.5 -0.8 -0.3 1.3 0.0 -1.7
Eye problems/disorders: None of the above 0.8 1.0 3.0 1.4 0.3 -0.6 0.6 1.7 0.6
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.7 -0.4 0.3 0.1 0.8 0.3 0.5
Emphysema/chronic bronchitis 0.8 0.9 1.8 -0.1 -1.3 -0.9 -1.2 -0.1 -1.2
Medication for pain relief, constipation, heartburn 0.9 1.5 2.5 -0.7 1.3 1.6 1.6 0.3 1.2
Neck or shoulder pain in last month 0.3 0.5 1.3 1.1 -0.1 -0.6 -1.1 -0.1 0.3
Medication: Blood pressure 0.3 0.5 1.4 1.2 -0.8 -0.3 -0.9 0.1 -0.6
Angina (self-reported) 1.3 1.7 3.9 0.9 1.3 0.1 1.5 1.2 2.0
Migraine (self-reported) 1.0 1.2 4.0 1.4 -0.1 0.4 -2.0 -0.4 0.9
Medication: Ibuprofen 1.5 1.8 4.3 0.6 -2.0 0.0 -1.4 0.3 -2.1
Medication: Allopurinol 0.2 0.2 0.5 0.7 -0.6 0.2 -0.6 0.1 -0.3
Medication: Omeprazole 0.2 0.2 0.7 0.3 -0.8 0.2 -0.4 -0.2 -0.5
Medication: Seretide 50 evohaler 0.9 1.1 2.9 -0.4 -0.5 -0.9 -1.7 -1.5 -0.4
Mean time to correctly identify matches 0.7 1.3 3.7 1.9 -0.3 0.1 0.1 1.9 0.3
Heart disease (mother) 0.4 0.5 1.3 1.1 0.7 0.1 1.0 0.2 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.6 0.4 -0.5 -0.8 0.5 0.2 -0.6
Whole body fat mass 0.4 1.7 4.8 -1.3 -2.2 -0.9 0.0 -0.5 -1.7
Leg fat mass (right) 0.4 1.5 3.6 -1.2 -1.7 -0.8 0.0 -0.6 -1.9
Arm predicted mass (right) 1.1 5.7 13.3 -2.1 -3.2 -2.1 0.6 -1.0 -3.6
Pulse rate, automated reading 3.5 11.4 29.8 3.9 2.5 5.5 -0.2 4.1 0.2
Alcohol intake frequency. 0.3 0.6 2.8 -0.2 -0.5 -1.7 0.2 0.2 0.7
Comparative height size at age 10 0.4 2.5 4.3 -1.6 -2.1 -0.3 1.8 0.9 -1.9
Number of full sisters 1.3 1.5 3.3 0.7 1.4 1.7 -0.6 0.4 1.8
Suffer from ‘nerves’ 0.8 1.2 3.3 -1.1 -1.8 -0.2 -0.6 -0.8 -1.3
Overall health rating 0.3 0.6 1.5 -0.3 -0.3 -1.2 -0.7 -1.0 -0.7
Chest pain or discomfort 0.5 0.7 3.3 1.8 -0.2 0.1 -0.5 0.5 -0.7
Had major operations 1.6 1.8 3.6 1.2 -1.7 0.2 -1.9 0.4 -1.7
Age at last live birth 0.5 0.7 2.0 0.4 0.8 -0.2 1.2 1.4 -0.1
Family relationship satisfaction 1.6 2.0 3.8 1.9 -1.2 1.0 -1.4 1.6 -1.2
Leg pain on walking 0.3 0.4 1.4 -0.5 0.7 -0.0 0.0 -1.2 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.5 -0.2 -0.8 1.2 0.6 0.8 -0.5
Commuting to job workplace: Car/motor vehicle 2.6 3.0 5.4 -1.5 2.3 -0.8 2.1 -2.1 0.7
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 4.1 -0.8 0.6 -1.9 1.2 -2.0 0.1
Medication: Aspirin 0.2 0.3 1.0 1.0 0.4 -0.3 -0.4 0.4 0.5
Supplements: Vitamin C 0.8 1.0 3.1 1.1 -1.0 -0.3 -1.8 0.8 -0.3
Knee pain experienced in last month 0.2 0.3 0.5 0.2 -0.7 -0.7 -0.6 0.2 -0.4
Hypertension (Self-reported) 0.2 0.6 2.5 1.6 0.1 -0.9 -0.4 0.1 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.3 1.1 -0.2 1.1 -1.0 0.5 -0.2
Illnesses of father: Heart disease 0.4 0.5 1.3 0.1 1.1 -0.7 0.4 0.6 -0.9
Illnesses of siblings: Diabetes 0.4 0.5 0.9 0.5 -0.8 -0.4 0.3 0.9 -0.9
Smoking status: Previous 0.1 0.1 0.2 -0.1 -0.3 0.1 -0.4 -0.2 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.8 -1.2 0.2 -0.7 1.7 -0.2 -0.4
Whole body fat-free mass 1.2 7.0 16.1 -2.5 -3.5 -2.2 1.1 -1.0 -4.0
Leg fat-free mass (right) 1.3 7.1 16.2 -2.3 -4.0 -2.0 0.2 -0.7 -4.0
Arm fat percentage (left) 0.2 0.9 2.0 -1.3 -1.4 -0.4 -0.1 -0.7 -1.0
Average weekly red wine intake 0.6 0.9 1.7 -0.8 -0.5 -1.1 1.1 -1.3 -0.8
Handedness (chirality/laterality): Left-handed 1.0 1.2 3.8 -2.0 0.4 1.0 0.6 -0.3 -1.3
Mood swings 0.9 1.6 4.9 0.4 -0.9 1.6 -2.2 -0.9 -0.7
Loneliness, isolation 0.1 0.1 0.4 0.4 -0.6 -0.2 -0.3 0.4 -0.0
Long-standing illness, disability or infirmity 0.7 1.1 2.6 -1.2 -0.5 -1.6 0.6 -0.9 -1.0
Ever had bowel cancer screening 0.2 0.2 0.7 0.2 -0.8 0.3 0.4 0.3 0.6
Diabetes diagnosed by doctor 0.6 1.0 2.3 1.2 -0.3 0.9 -1.5 -0.2 1.0
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.8 2.9 1.6 1.1 -1.4 -1.1 -0.8 1.7
Friendships satisfaction 0.8 1.0 2.5 0.8 -0.6 0.8 -0.9 1.6 -1.0
Qualifications: nursing, teaching 0.3 0.5 1.3 -1.1 0.5 0.3 0.0 -1.1 0.4
Commuting to job workplace: Walk 2.0 2.2 7.3 0.7 -2.7 -0.7 -2.1 -0.1 -0.5
Eye problems/disorders: Cataract 1.5 1.7 4.1 0.0 -2.0 -0.6 -1.3 -0.2 -2.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.6 0.0 -0.6 0.4 -1.3 -0.0 0.2
Medication for cholesterol 0.9 1.4 4.5 -2.1 -0.2 1.2 0.4 -1.4 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.0 0.0 0.2 0.6 -1.0 0.2 0.7
Back pain experienced in last month 1.2 1.8 5.4 1.9 -0.9 0.4 -2.3 0.6 0.5
Mineral and other dietary supplements 1.2 1.6 6.3 -2.5 0.1 -0.3 0.8 -1.5 -0.3
Breast cancer (self-reported) 0.7 0.9 1.9 0.6 0.2 1.4 -1.3 -0.4 1.1
Asthma (self-reported) 0.4 0.8 1.6 -0.4 -0.7 -1.0 -1.3 -1.2 -0.1
Osteoporosis (self-reported) 1.8 2.2 7.0 2.6 0.1 -0.1 -2.1 1.3 0.2
Osteoarthritis (self-reported) 1.1 1.4 4.5 2.1 -0.3 -0.9 -1.4 1.0 0.3
Medication: Aspirin 0.4 0.6 1.9 1.4 0.5 -0.2 -0.8 0.5 0.6
Medication: Gliclazide 0.7 0.8 2.4 1.5 0.8 -0.0 0.1 0.5 1.2
Illnesses of father: None of the above (group 1) 0.8 1.0 2.2 0.2 -0.1 1.5 -1.2 0.3 1.5
Smoking status: Current 1.0 1.5 4.4 2.1 0.4 0.3 -0.3 1.8 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 2.0 -0.8 -0.0 0.1 0.2 -1.4 0.5
Whole body water mass 1.2 7.1 16.8 -2.6 -3.6 -2.1 1.0 -1.0 -4.1
Leg predicted mass (right) 1.3 7.0 16.1 -2.3 -4.0 -2.1 0.2 -0.7 -4.0
Arm fat mass (left) 0.5 2.2 4.5 -1.6 -2.1 -1.1 0.2 -0.9 -1.9
Number of self-reported non-cancer illnesses 1.1 1.9 4.3 -1.4 0.8 -1.7 2.1 -1.2 0.2
Average weekly champagne plus white wine intake 0.2 0.3 1.2 0.5 -0.6 0.2 -1.1 0.1 -0.2
Miserableness 1.5 2.5 6.1 0.9 -0.2 2.5 -2.5 -0.2 1.4
Guilty feelings 2.2 3.3 8.7 1.6 -1.0 2.6 -2.9 0.7 0.1
Wears glasses or contact lenses 0.6 0.7 1.2 -0.8 -0.8 -0.8 0.3 -1.1 -1.1
Ever taken oral contraceptive pill 0.4 0.5 1.4 -1.2 -0.3 1.0 -0.0 0.3 -0.3
Hearing aid user 0.9 1.0 2.0 -0.8 -0.6 -1.0 1.0 -1.4 -0.9
Mother’s age at death 0.6 0.8 1.7 1.1 -0.6 0.1 -1.3 0.5 -1.0
Financial situation satisfaction 1.4 1.7 4.1 2.0 0.3 1.1 -0.8 1.8 1.0
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.4 0.6 0.0 -0.4 -0.4 0.5 -0.6
Commuting to job workplace: Public transport 0.5 0.6 2.1 -0.4 -1.5 -0.2 0.7 0.2 -0.7
Eye problems/disorders: Glaucoma 1.1 1.3 2.3 1.3 -1.4 0.7 -1.5 0.3 -1.2
Medication: Blood pressure 0.3 0.5 1.4 1.2 0.3 -0.9 0.1 0.2 0.6
Pain type(s) experienced in last month: Hip pain 1.1 1.3 4.5 1.3 -1.1 0.4 -2.1 0.6 0.1
Supplements: Fish oil (including cod liver oil) 0.8 1.0 3.2 1.8 -0.3 0.3 -0.4 1.7 0.0
High cholesterol (Self-reported) 0.6 1.0 3.5 -0.5 0.7 -1.9 1.1 -0.9 0.1
Medication: Bendroflumethiazide 0.4 0.6 1.5 1.1 -0.1 0.1 -1.0 0.3 1.2
Medication: Paracetamol 0.4 0.6 1.8 -0.0 -1.1 -0.1 -1.3 -0.6 -0.1
Medication: Lisinopril 0.7 1.0 3.5 1.9 0.6 -0.9 -0.4 -0.4 0.9
Medication: Atorvastatin 0.6 0.8 3.6 0.7 -0.1 0.3 -0.2 1.9 -0.6
Illnesses of father: High blood pressure 2.4 2.9 7.8 0.8 -2.2 -2.0 -0.5 0.1 -2.8
Alcohol drinker status: Never 0.6 0.8 3.1 0.2 1.1 0.2 0.2 -0.5 1.8
Ever smoked 0.9 1.5 4.7 1.4 -0.9 0.6 -1.0 2.2 -0.6
Basal metabolic rate 1.2 6.6 14.6 -2.6 -3.5 -2.0 0.8 -1.0 -3.8
Leg fat percentage (left) 0.2 0.7 1.5 0.1 -1.2 -0.2 -1.2 -0.1 -1.2
Arm fat-free mass (left) 1.1 5.8 12.7 -2.3 -3.1 -2.3 0.7 -1.2 -3.6
Number of operations (self-reported) 1.1 1.6 5.7 1.1 -0.5 -2.4 -0.4 0.3 -1.5
Average weekly beer plus cider intake 2.0 2.9 10.9 -3.3 -0.5 0.8 0.9 -1.7 -1.4
Irritability 0.6 1.1 3.1 0.3 -1.6 0.6 -1.8 0.1 -0.5
Risk taking 0.7 1.0 2.6 -0.6 1.1 0.0 -0.9 -1.1 1.6
Ever had prostate specific antigen (PSA) test 1.1 1.3 3.4 -1.3 -0.2 -1.9 1.4 -0.6 0.5
Fractured/broken bones in last 5 years 1.1 1.4 6.5 1.1 0.3 -0.4 -2.5 -0.6 -0.3
Age started oral contraceptive pill 0.3 0.4 1.0 0.9 0.1 1.0 -0.7 -0.3 0.3
Diastolic blood pressure, automated reading 0.4 1.1 3.5 1.1 0.2 -0.7 -0.1 1.9 -1.2
Ever depressed for a whole week 0.5 0.7 2.1 -1.5 -0.7 0.5 0.9 -0.5 -0.2
Unable to work because of sickness or disability 0.9 1.1 2.1 1.2 1.5 0.5 -0.8 0.5 1.4
Commuting to job workplace: Cycle 0.3 0.4 1.3 -0.7 -0.0 1.2 -0.5 0.5 -0.1
Myopia 0.2 0.3 0.9 -0.1 -0.6 -0.7 0.5 0.9 -0.3
Vascular/heart problems diagnosed by doctor 0.3 0.8 3.6 -1.9 -0.4 0.5 0.2 -0.5 -0.9
Cholesterol lowering medication 0.6 0.9 2.1 0.7 -0.7 -1.5 0.1 1.3 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.4 0.5 -0.2 -0.2 0.7 0.3 -0.1
Pain experienced in last month 0.5 0.9 3.7 -0.7 0.3 -0.6 1.9 0.6 -0.6
Supplements: Calcium 1.5 1.6 4.5 2.1 -0.3 0.6 -1.7 1.0 1.0
Basal cell carcinoma (self-reported) 0.5 0.6 1.5 -0.1 0.8 -1.2 0.6 1.1 0.2
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.6 -0.4 -0.4 -1.1 1.3 -0.6 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.1 0.7 -0.7 -1.1 0.7 0.5 -0.3
Heart disease (siblings) 1.5 1.8 4.6 -1.4 -0.9 -2.1 1.2 0.7 -1.3
Alcohol drinker status: Previous 0.9 1.1 3.8 1.2 -0.5 -0.1 -2.0 0.1 0.8
Pack years of smoking 0.6 0.9 3.7 0.5 0.6 -1.9 0.1 -1.1 0.1
Impedance of whole body 0.8 4.0 10.0 1.9 2.4 1.7 0.2 1.2 3.2
Leg fat mass (left) 0.5 2.1 5.3 -1.1 -2.1 -1.1 -0.2 -0.5 -2.3
Arm predicted mass (left) 1.1 5.4 12.9 -2.1 -3.2 -1.9 0.6 -1.0 -3.6