TWAS hub - CPNE5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1540	0.0520	2.1e-03	0.012	NA	0.028	NA	0.032	7.5e-02	NA	1.3e-02	NA	8.8e-03
2	GTEx	Brain Cerebellum	0.2280	0.0820	6.0e-03	-0.007	NA	0.003	NA	-0.010	5.9e-01	NA	2.6e-01	NA	9.1e-01
3	GTEx	Nerve Tibial	0.2025	0.0494	1.1e-05	0.177	NA	0.152	NA	0.129	1.3e-12	NA	6.5e-11	NA	2.3e-09
4	ROSMAP	Brain Pre-frontal Cortex	0.0524	0.0222	5.3e-03	-0.001	0.018	0.000	0.017	0.000	4.2e-01	1.9e-03	3.6e-01	2.5e-03	3.2e-01
5	YFS	Blood	0.0595	0.0131	5.8e-14	0.044	0.048	0.056	0.053	0.052	3.4e-14	2.6e-15	1.0e-17	6.8e-17	1.2e-16
6	TCGA	Prostate Adenocarcinoma	0.0493	0.0215	4.0e-03	0.007	0.031	0.009	NA	0.017	5.0e-02	3.4e-04	3.6e-02	NA	6.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Pulse rate, automated reading	3.5	11.4	29.8	3.9	2.5	5.5	-0.2	4.1	0.2
Sensitivity / hurt feelings	3.3	5.6	14.1	2.7	0.8	3.8	-1.9	2.2	1.7
Severe depression (siblings)	2.6	2.9	4.8	-1.4	-2.2	1.7	-1.9	-0.9	-1.8
Commuting to job workplace: Car/motor vehicle	2.6	3.0	5.4	-1.5	2.3	-0.8	2.1	-2.1	0.7
Townsend deprivation index at recruitment	2.4	3.4	7.6	0.9	-2.6	0.5	0.4	2.8	-2.1
Illnesses of father: High blood pressure	2.4	2.9	7.8	0.8	-2.2	-2.0	-0.5	0.1	-2.8
Pain all over the body in last month	2.3	2.4	6.7	-0.2	2.6	0.6	0.9	-0.8	2.4
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	9.7	-0.1	-3.1	0.3	-1.8	0.6	-3.0
Birth weight of first child	2.3	4.1	11.9	-2.2	-2.6	-0.3	-0.5	-1.0	-3.4
Guilty feelings	2.2	3.3	8.7	1.6	-1.0	2.6	-2.9	0.7	0.1
Neuroticism (Nagel 2018)	2.1	4.8	14.5	2.3	-2.1	2.0	-3.8	1.0	-0.1
Coronary Artery Disease (CAD)	2.1	2.5	8.3	2.9	0.4	-1.3	1.5	1.5	0.5
Pulse wave reflection index	2.1	2.6	5.3	0.2	-2.1	-0.7	-0.9	2.3	-2.0
Mouth/teeth dental problems: Dentures	2.0	3.4	8.4	2.9	-1.7	0.2	-2.3	1.6	-0.8
Medication: Lansoprazole	2.0	2.3	5.6	0.5	2.4	1.2	-0.9	-0.5	2.4
Commuting to job workplace: Walk	2.0	2.2	7.3	0.7	-2.7	-0.7	-2.1	-0.1	-0.5
Average weekly beer plus cider intake	2.0	2.9	10.9	-3.3	-0.5	0.8	0.9	-1.7	-1.4
Depression (self-reported)	1.9	2.3	6.1	-0.3	-2.0	1.4	-2.5	-0.6	-1.3
Happiness	1.8	2.2	6.7	1.4	0.3	1.8	-0.0	2.6	1.0
Exposure to tobacco smoke outside home	1.8	2.4	6.4	0.5	-1.5	2.1	-2.5	-1.1	-0.1
Osteoporosis (self-reported)	1.8	2.2	7.0	2.6	0.1	-0.1	-2.1	1.3	0.2
Depression (Nagel 2018)	1.7	2.6	6.2	1.1	-2.5	-0.1	-1.5	0.9	-2.2
Crohns Disease (2012)	1.7	2.7	4.1	-2.0	-1.1	-2.0	1.8	0.3	-1.9
Maternal smoking around birth	1.7	2.5	5.7	2.4	0.7	0.6	-0.9	2.3	1.5
Crohns Disease (2017)	1.6	3.4	7.1	-2.3	-2.4	-1.5	0.6	-0.0	-2.7
Neuroticism (2016)	1.6	2.3	5.1	1.5	-1.5	1.4	-2.3	1.4	-0.4
Supplements: Glucosamine	1.6	2.0	6.1	2.5	-0.2	-0.9	-1.5	1.5	0.9
Pulse wave peak to peak time	1.6	1.8	6.4	-0.3	0.5	-2.0	0.3	-2.5	0.5
Had major operations	1.6	1.8	3.6	1.2	-1.7	0.2	-1.9	0.4	-1.7
Family relationship satisfaction	1.6	2.0	3.8	1.9	-1.2	1.0	-1.4	1.6	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.8	2.9	1.6	1.1	-1.4	-1.1	-0.8	1.7
Depressed Affect (Nagel 2018)	1.5	3.1	9.4	1.8	-0.8	2.0	-3.1	0.8	1.0
Neuroticism	1.5	3.6	11.4	2.1	-0.9	2.1	-3.4	0.0	0.2
Number of treatments/medications taken	1.5	2.6	6.5	2.3	-1.6	-0.8	-2.5	0.4	-0.6
Hearing difficulty/problems: Yes	1.5	2.3	6.1	-0.6	-1.7	-2.1	-0.2	0.4	-2.5
Angina	1.5	2.0	4.5	1.1	1.3	-0.3	1.6	1.3	2.1
Medication for hormone replacement therapy	1.5	1.7	4.9	2.2	0.3	-1.5	-1.0	1.3	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	5.0	0.6	-2.2	0.1	-1.6	0.8	-1.9
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.5	-2.1	1.5	-0.3	0.5	-1.9	0.2
Medication: Ibuprofen	1.5	1.8	4.3	0.6	-2.0	0.0	-1.4	0.3	-2.1
Eye problems/disorders: Cataract	1.5	1.7	4.1	0.0	-2.0	-0.6	-1.3	-0.2	-2.0
Miserableness	1.5	2.5	6.1	0.9	-0.2	2.5	-2.5	-0.2	1.4
Supplements: Calcium	1.5	1.6	4.5	2.1	-0.3	0.6	-1.7	1.0	1.0
Heart disease (siblings)	1.5	1.8	4.6	-1.4	-0.9	-2.1	1.2	0.7	-1.3
Lupus	1.4	2.1	3.8	-0.9	1.9	1.9	1.1	-0.2	1.8
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	4.4	-0.3	2.1	-0.2	1.0	-1.3	1.2
Pulse rate	1.4	2.3	6.5	1.5	1.8	2.5	0.5	1.1	0.8
Pulse wave Arterial Stiffness index	1.4	1.6	6.1	0.1	-0.8	1.6	-0.1	2.5	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.9	6.8	0.7	-0.8	2.6	-1.6	0.5	-0.7
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	4.1	-0.8	0.6	-1.9	1.2	-2.0	0.1
Financial situation satisfaction	1.4	1.7	4.1	2.0	0.3	1.1	-0.8	1.8	1.0
Breast Cancer	1.3	3.1	9.4	-1.5	2.6	-0.3	3.1	0.3	0.7
HbA1C	1.3	1.5	6.8	-0.0	0.6	2.6	-0.2	1.1	0.6
Number of incorrect matches in round	1.3	2.1	9.9	3.1	1.1	0.7	-0.6	0.1	0.9
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	6.4	-0.8	-1.3	2.5	-0.5	0.4	-0.5
Length of working week for main job	1.3	1.5	3.2	-1.2	-0.9	-0.1	-1.8	-1.8	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	4.8	-0.8	-1.1	2.2	-2.0	-0.8	0.5
Loud music exposure frequency	1.3	1.4	4.2	-0.4	0.8	2.0	-0.0	1.8	0.6
Angina (self-reported)	1.3	1.7	3.9	0.9	1.3	0.1	1.5	1.2	2.0
Number of full sisters	1.3	1.5	3.3	0.7	1.4	1.7	-0.6	0.4	1.8
Leg fat-free mass (right)	1.3	7.1	16.2	-2.3	-4.0	-2.0	0.2	-0.7	-4.0
Leg predicted mass (right)	1.3	7.0	16.1	-2.3	-4.0	-2.1	0.2	-0.7	-4.0
Heel T-Score	1.2	9.5	20.6	3.0	2.5	4.5	-3.0	0.7	3.5
Frequency of depressed mood in last 2 weeks	1.2	1.6	3.7	0.8	-1.9	0.4	-0.6	1.2	-1.9
Ever used hormone-replacement therapy (HRT)	1.2	1.5	5.8	2.4	0.0	-0.7	-1.0	1.0	0.9
Supplements: Zinc	1.2	1.3	3.8	2.0	-0.9	-0.4	-1.4	0.8	0.5
Leg fat-free mass (left)	1.2	6.3	14.5	-2.5	-3.5	-1.8	0.7	-0.8	-3.8
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	4.8	0.3	-0.0	-2.2	0.8	1.5	-0.6
Medication: Atenolol	1.2	1.5	2.9	1.5	0.7	1.1	0.1	1.5	1.7
Leg predicted mass (left)	1.2	6.2	14.2	-2.4	-3.5	-1.8	0.7	-0.7	-3.8
Neuroticism score	1.2	2.5	7.7	1.2	-0.8	2.3	-2.8	-0.2	0.3
Trunk fat-free mass	1.2	6.6	14.7	-2.7	-3.2	-2.2	1.2	-1.1	-3.8
Prospective memory result	1.2	1.4	3.1	-1.0	1.2	-0.3	1.6	-1.8	-0.6
Trunk predicted mass	1.2	7.0	15.3	-2.8	-3.3	-2.2	1.3	-1.2	-3.9
Breastfed as a baby	1.2	1.5	3.7	-1.9	1.3	-0.8	1.6	-0.4	-0.4
Ever highly irritable/argumentative for 2 days	1.2	1.4	4.5	0.3	0.9	2.1	-1.2	1.1	0.6
Whole body fat-free mass	1.2	7.0	16.1	-2.5	-3.5	-2.2	1.1	-1.0	-4.0
Back pain experienced in last month	1.2	1.8	5.4	1.9	-0.9	0.4	-2.3	0.6	0.5
Mineral and other dietary supplements	1.2	1.6	6.3	-2.5	0.1	-0.3	0.8	-1.5	-0.3
Whole body water mass	1.2	7.1	16.8	-2.6	-3.6	-2.1	1.0	-1.0	-4.1
Basal metabolic rate	1.2	6.6	14.6	-2.6	-3.5	-2.0	0.8	-1.0	-3.8
Worry (Nagel 2018)	1.1	2.3	6.5	0.8	-2.3	0.2	-2.5	-0.3	-1.0
Vitamin and mineral supplements	1.1	1.5	4.7	-2.2	-0.5	0.6	1.6	-1.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	9.2	0.6	1.3	3.0	-1.3	-0.4	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.2	1.1	1.2	1.5	-0.1	1.0	1.4
Arm predicted mass (right)	1.1	5.7	13.3	-2.1	-3.2	-2.1	0.6	-1.0	-3.6
Osteoarthritis (self-reported)	1.1	1.4	4.5	2.1	-0.3	-0.9	-1.4	1.0	0.3
Number of self-reported non-cancer illnesses	1.1	1.9	4.3	-1.4	0.8	-1.7	2.1	-1.2	0.2
Eye problems/disorders: Glaucoma	1.1	1.3	2.3	1.3	-1.4	0.7	-1.5	0.3	-1.2
Pain type(s) experienced in last month: Hip pain	1.1	1.3	4.5	1.3	-1.1	0.4	-2.1	0.6	0.1
Arm fat-free mass (left)	1.1	5.8	12.7	-2.3	-3.1	-2.3	0.7	-1.2	-3.6
Number of operations (self-reported)	1.1	1.6	5.7	1.1	-0.5	-2.4	-0.4	0.3	-1.5
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.4	-1.3	-0.2	-1.9	1.4	-0.6	0.5
Fractured/broken bones in last 5 years	1.1	1.4	6.5	1.1	0.3	-0.4	-2.5	-0.6	-0.3
Arm predicted mass (left)	1.1	5.4	12.9	-2.1	-3.2	-1.9	0.6	-1.0	-3.6
Bipolar Disorder (2018)	1.0	1.5	7.1	-2.7	0.1	0.4	1.0	-0.8	-0.4
Age at First Birth	1.0	1.4	2.4	-0.6	1.2	-0.6	1.4	1.4	1.5
Fasting Glucose	1.0	1.2	4.2	0.4	0.0	1.4	-2.1	-0.0	0.9
Impedance of leg (right)	1.0	4.7	10.3	1.6	3.2	2.0	0.8	0.6	3.2
Had menopause	1.0	1.3	3.5	1.9	-1.2	-0.4	-0.8	1.3	0.2
Financial difficulties in last 2 years	1.0	1.3	2.7	1.2	0.3	1.6	-0.9	1.7	0.4
Medication: Ramipril	1.0	1.3	5.6	-0.4	0.3	-1.3	2.4	0.5	-0.4
Medication: Simvastatin	1.0	1.5	3.7	-1.4	-0.2	-1.5	1.0	-1.9	0.3
Alcohol intake versus 10 years previously	1.0	1.5	4.0	-1.8	-0.8	-0.7	2.0	0.8	-0.1
Hair/balding pattern: Pattern 3	1.0	1.5	4.6	-0.1	2.1	0.1	1.7	0.4	1.2
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	3.5	1.1	-0.9	-0.5	-0.8	0.9	-1.9
Glaucoma (self-reported)	1.0	1.2	2.6	1.3	-1.2	0.3	-1.6	0.1	-1.1
Arm fat-free mass (right)	1.0	5.3	13.2	-1.8	-3.0	-2.3	0.8	-0.7	-3.6
Comparative body size at age 10	1.0	2.8	8.5	0.8	1.8	0.6	-2.9	-0.7	1.8
Migraine (self-reported)	1.0	1.2	4.0	1.4	-0.1	0.4	-2.0	-0.4	0.9
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.8	-2.0	0.4	1.0	0.6	-0.3	-1.3
Smoking status: Current	1.0	1.5	4.4	2.1	0.4	0.3	-0.3	1.8	1.0
Alzheimer’s Disease (in father)	0.9	1.0	2.6	-1.0	1.1	-0.1	1.0	-0.4	1.6
Ever had hysterectomy (womb removed)	0.9	1.0	2.6	1.2	0.6	-0.8	-0.5	1.6	0.6
Current tobacco smoking	0.9	1.5	4.1	2.0	0.3	0.2	-0.3	2.0	0.9
Fed-up feelings	0.9	1.7	4.5	-0.1	-1.4	1.8	-2.1	0.1	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	3.0	-0.5	-1.7	1.1	-1.7	-0.8	-0.9
Weight	0.9	4.2	9.9	-1.8	-3.1	-1.7	0.1	-0.8	-3.0
Hair/balding pattern: Pattern 4	0.9	2.3	8.3	2.9	-1.1	0.7	-1.6	1.1	-0.2
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	5.4	2.3	0.4	0.4	-1.2	0.8	1.0
Medication for pain relief, constipation, heartburn	0.9	1.5	2.5	-0.7	1.3	1.6	1.6	0.3	1.2
Medication: Seretide 50 evohaler	0.9	1.1	2.9	-0.4	-0.5	-0.9	-1.7	-1.5	-0.4
Mood swings	0.9	1.6	4.9	0.4	-0.9	1.6	-2.2	-0.9	-0.7
Medication for cholesterol	0.9	1.4	4.5	-2.1	-0.2	1.2	0.4	-1.4	-0.3
Hearing aid user	0.9	1.0	2.0	-0.8	-0.6	-1.0	1.0	-1.4	-0.9
Ever smoked	0.9	1.5	4.7	1.4	-0.9	0.6	-1.0	2.2	-0.6
Unable to work because of sickness or disability	0.9	1.1	2.1	1.2	1.5	0.5	-0.8	0.5	1.4
Alcohol drinker status: Previous	0.9	1.1	3.8	1.2	-0.5	-0.1	-2.0	0.1	0.8
Irritable Bowel Disease (IBD)	0.8	1.8	4.6	-1.2	-2.1	-0.4	0.6	0.6	-2.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.1	-1.4	-1.1	-1.4	-0.1	-0.1	-0.3
Systolic blood pressure, automated reading	0.8	2.5	9.5	-0.9	-1.2	-3.1	1.5	0.0	-0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.9	-0.5	-0.6	1.1	0.4	1.7	-0.8
Serious illness, injury or assault to yourself	0.8	1.0	3.0	-1.7	0.8	1.3	0.5	-0.5	-0.0
Chronic bronchitis/emphysema (father)	0.8	0.9	2.4	-1.6	0.0	0.0	1.2	-0.9	-0.7
Worrier / anxious feelings	0.8	1.5	3.9	0.2	-1.6	-0.0	-2.0	-0.9	-1.4
Illnesses of mother	0.8	1.0	4.0	-2.0	-0.2	0.1	0.3	-1.2	-0.4
High blood pressure (siblings)	0.8	1.1	3.4	1.6	0.4	-1.8	-0.6	-0.4	-0.3
Number of full brothers	0.8	1.0	3.5	-0.4	-1.3	-1.9	-0.5	-0.8	-0.2
Eye problems/disorders: None of the above	0.8	1.0	3.0	1.4	0.3	-0.6	0.6	1.7	0.6
Emphysema/chronic bronchitis	0.8	0.9	1.8	-0.1	-1.3	-0.9	-1.2	-0.1	-1.2
Suffer from ‘nerves’	0.8	1.2	3.3	-1.1	-1.8	-0.2	-0.6	-0.8	-1.3
Supplements: Vitamin C	0.8	1.0	3.1	1.1	-1.0	-0.3	-1.8	0.8	-0.3
Friendships satisfaction	0.8	1.0	2.5	0.8	-0.6	0.8	-0.9	1.6	-1.0
Illnesses of father: None of the above (group 1)	0.8	1.0	2.2	0.2	-0.1	1.5	-1.2	0.3	1.5
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.2	1.8	-0.3	0.3	-0.4	1.7	0.0
Impedance of whole body	0.8	4.0	10.0	1.9	2.4	1.7	0.2	1.2	3.2
Schizophrenia vs Biploar Disorder	0.7	0.9	1.8	1.3	0.2	1.3	-1.0	-0.0	0.9
HDL Cholesterol	0.7	1.2	4.8	0.6	1.4	-0.0	0.3	-0.5	2.2
Primary Biliary Cirrhosis	0.7	1.0	1.7	-0.4	0.6	1.3	1.2	1.3	0.7
Ulcerative Colitis	0.7	0.9	2.1	-0.5	-1.5	0.4	0.8	1.3	-0.9
Blood White Count	0.7	5.0	15.2	-3.9	-1.0	0.2	3.5	0.9	-0.5
Pack years adult smoking proportion	0.7	1.1	3.8	0.3	0.7	-1.9	-0.4	-1.3	0.4
Average weekly fortified wine intake	0.7	0.8	2.6	0.5	0.1	1.6	-1.1	0.0	-0.8
Multivitamins +/- minerals	0.7	0.9	2.8	1.7	1.2	-0.4	-0.7	0.6	0.6
Medication: Levothyroxine sodium	0.7	1.2	3.9	-2.0	0.9	-0.1	1.1	-1.1	-0.1
Impedance of leg (left)	0.7	3.3	7.1	2.0	2.5	1.6	-0.0	0.7	2.7
Nervous feelings	0.7	1.4	4.0	-0.1	-0.3	1.9	-2.0	-0.8	0.3
Hair/balding pattern: Pattern 2	0.7	0.9	2.0	0.1	-1.4	-0.1	-1.4	-0.7	-0.9
Mouth/teeth dental problems	0.7	1.1	3.4	-0.7	1.5	-0.7	1.8	-0.3	-0.1
Hip circumference	0.7	2.9	5.9	-1.9	-2.1	-1.1	0.3	-1.4	-2.4
Falls in the last year	0.7	0.9	3.4	0.8	-0.5	-0.3	-1.8	-1.0	0.6
Gout (self-reported)	0.7	0.9	2.1	1.5	0.5	1.0	-0.6	0.6	1.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	1.8	-1.4	1.4	1.4	1.2	-0.1	0.9
Medication: Amlodipine	0.7	0.9	3.6	0.2	-0.2	-1.9	1.3	0.2	-0.4
Chronic bronchitis/emphysema (mother)	0.7	0.9	3.3	0.0	0.5	1.1	-0.3	-0.5	1.8
Worry too long after embarrassment	0.7	1.2	2.5	1.2	-1.1	1.6	-1.4	-0.3	0.0
Number of children fathered	0.7	0.7	1.5	-1.0	-0.3	-1.2	0.7	-1.1	-0.2
Mean time to correctly identify matches	0.7	1.3	3.7	1.9	-0.3	0.1	0.1	1.9	0.3
Long-standing illness, disability or infirmity	0.7	1.1	2.6	-1.2	-0.5	-1.6	0.6	-0.9	-1.0
Breast cancer (self-reported)	0.7	0.9	1.9	0.6	0.2	1.4	-1.3	-0.4	1.1
Medication: Gliclazide	0.7	0.8	2.4	1.5	0.8	-0.0	0.1	0.5	1.2
Medication: Lisinopril	0.7	1.0	3.5	1.9	0.6	-0.9	-0.4	-0.4	0.9
Risk taking	0.7	1.0	2.6	-0.6	1.1	0.0	-0.9	-1.1	1.6
Systolic Blood Pressure	0.6	3.1	10.6	-0.6	-0.2	-2.7	3.3	0.8	-0.3
Hypothyroidism (self reported)	0.6	1.3	3.4	-1.8	0.8	1.4	0.4	-1.0	0.7
Average weekly spirits intake	0.6	0.7	1.7	0.7	-0.6	0.8	-1.3	-0.8	-0.6
Medication: Metformin	0.6	0.8	1.8	1.3	-0.7	0.3	-1.3	-0.5	0.6
Diabetes (father)	0.6	0.8	1.6	1.0	-0.8	0.8	0.4	1.3	-0.7
High blood pressure (mother)	0.6	0.8	3.0	1.7	0.4	-1.2	-0.5	0.4	-0.1
Alcohol usually taken with meals	0.6	1.0	2.3	-0.5	-1.5	-1.1	-0.1	-1.4	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.5	0.2	1.2	2.1	-0.8	-0.9	0.7
Noisy workplace	0.6	0.8	2.6	0.5	-0.1	1.6	-1.1	-0.1	0.6
Qualifications: College or University degree	0.6	1.9	6.2	-2.5	-0.8	-0.3	1.3	0.0	-1.7
Average weekly red wine intake	0.6	0.9	1.7	-0.8	-0.5	-1.1	1.1	-1.3	-0.8
Diabetes diagnosed by doctor	0.6	1.0	2.3	1.2	-0.3	0.9	-1.5	-0.2	1.0
Wears glasses or contact lenses	0.6	0.7	1.2	-0.8	-0.8	-0.8	0.3	-1.1	-1.1
Mother’s age at death	0.6	0.8	1.7	1.1	-0.6	0.1	-1.3	0.5	-1.0
High cholesterol (Self-reported)	0.6	1.0	3.5	-0.5	0.7	-1.9	1.1	-0.9	0.1
Medication: Atorvastatin	0.6	0.8	3.6	0.7	-0.1	0.3	-0.2	1.9	-0.6
Alcohol drinker status: Never	0.6	0.8	3.1	0.2	1.1	0.2	0.2	-0.5	1.8
Irritability	0.6	1.1	3.1	0.3	-1.6	0.6	-1.8	0.1	-0.5
Cholesterol lowering medication	0.6	0.9	2.1	0.7	-0.7	-1.5	0.1	1.3	-0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.6	-0.4	-0.4	-1.1	1.3	-0.6	-1.2
Pack years of smoking	0.6	0.9	3.7	0.5	0.6	-1.9	0.1	-1.1	0.1
Major Depression (MDD)	0.5	0.6	1.9	-0.6	-1.1	-0.1	-0.5	-0.3	-1.4
Ovarian Cancer	0.5	0.6	1.5	-0.0	-0.9	-1.1	-0.1	-0.1	-1.2
Body Mass Index (BMI) (2010)	0.5	0.7	2.5	-1.6	0.0	0.7	0.4	-0.9	-0.1
Height	0.5	9.2	19.4	-2.3	-4.4	-2.8	2.9	-1.4	-3.4
Smoking Status	0.5	1.2	3.7	1.4	-0.4	1.0	-0.6	1.9	0.5
Lung FVC	0.5	2.6	7.0	1.7	-0.5	2.3	-2.6	0.2	0.0
Medication: Co-codamol	0.5	0.6	1.4	-0.4	0.7	-1.2	0.6	-1.0	0.1
Diabetes (mother)	0.5	0.7	1.0	-0.8	-1.0	-0.8	1.0	-0.2	-0.9
Taking other prescription medications	0.5	0.7	2.2	0.8	0.4	-0.7	-1.5	-0.7	0.6
Qualifications: CSEs or equivalent	0.5	0.6	2.0	0.6	-0.0	0.9	-1.4	0.1	0.6
Stomach or abdominal pain in last month	0.5	0.6	1.5	0.7	1.2	-0.1	0.2	0.8	0.9
Sitting height	0.5	3.6	5.8	-2.4	-2.0	-1.9	1.4	-1.6	-1.9
Body mass index (BMI)	0.5	2.0	3.8	-1.4	-1.9	-1.1	-0.5	-1.0	-1.9
Hearing difficulty/problems with background noise	0.5	0.7	1.7	-0.8	-0.8	-0.3	-1.3	-0.5	-1.1
Heart attack	0.5	0.6	1.6	-0.3	-0.1	-1.0	1.3	-0.6	-0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.5	-0.1	-0.8	0.5	-1.6	0.5	-0.8
Time employed in main current job	0.5	0.6	2.0	-0.9	0.6	-0.5	0.2	-0.6	1.4
Number of live births	0.5	0.7	3.4	0.2	0.2	-1.9	0.8	-0.3	0.1
Medication: Cholesterol lowering	0.5	0.8	2.1	-0.1	0.5	-0.1	0.8	-1.4	1.5
Lung cancer (father)	0.5	0.6	1.2	1.0	-0.8	-0.6	-0.3	1.1	-0.7
Impedance of arm (left)	0.5	2.3	6.4	1.3	1.4	1.6	0.1	1.0	2.5
Peak expiratory flow (PEF)	0.5	1.0	3.7	0.2	0.7	0.0	0.1	-1.4	1.9
Blood clot in the leg (DVT)	0.5	0.6	1.6	0.6	-0.7	-1.3	0.8	0.4	-0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.1	1.0	-1.0	-0.9	-0.5	0.3	-0.7
Chest pain or discomfort	0.5	0.7	3.3	1.8	-0.2	0.1	-0.5	0.5	-0.7
Age at last live birth	0.5	0.7	2.0	0.4	0.8	-0.2	1.2	1.4	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	-0.2	-0.8	1.2	0.6	0.8	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	1.1	-0.2	1.1	-1.0	0.5	-0.2
Arm fat mass (left)	0.5	2.2	4.5	-1.6	-2.1	-1.1	0.2	-0.9	-1.9
Commuting to job workplace: Public transport	0.5	0.6	2.1	-0.4	-1.5	-0.2	0.7	0.2	-0.7
Ever depressed for a whole week	0.5	0.7	2.1	-1.5	-0.7	0.5	0.9	-0.5	-0.2
Pain experienced in last month	0.5	0.9	3.7	-0.7	0.3	-0.6	1.9	0.6	-0.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.5	-0.1	0.8	-1.2	0.6	1.1	0.2
Leg fat mass (left)	0.5	2.1	5.3	-1.1	-2.1	-1.1	-0.2	-0.5	-2.3
Mean Putamen Volume	0.4	0.4	1.1	-1.1	0.5	-0.3	0.9	0.1	-0.4
Respiratory disease	0.4	0.9	2.0	-0.8	-1.1	-1.4	-0.7	-0.9	-0.6
Relative age of first facial hair	0.4	0.9	1.6	-0.8	-0.4	-1.3	0.9	-1.3	-0.8
Relative age voice broke	0.4	0.6	1.3	-0.4	-1.1	0.4	0.9	-0.4	-1.0
Trunk fat mass	0.4	1.6	5.2	-1.2	-2.3	-0.7	-0.1	-0.4	-1.6
Past tobacco smoking	0.4	0.6	1.3	-0.9	0.6	-0.9	0.7	-1.1	-0.2
Allergy	0.4	0.9	2.9	0.5	0.7	0.6	1.1	1.7	0.3
Diabetes (self-reported)	0.4	0.6	2.0	0.9	-0.6	0.3	-1.4	0.2	0.7
Fluid intelligence score	0.4	0.8	4.1	-2.0	-0.6	-0.5	0.2	-0.6	-0.2
Impedance of arm (right)	0.4	2.0	6.0	0.8	1.3	1.8	0.1	0.8	2.5
Asthma	0.4	0.9	2.5	-0.1	-0.8	-1.0	-1.6	-1.0	-0.3
Arm fat mass (right)	0.4	1.8	3.7	-1.7	-1.9	-1.1	0.1	-1.0	-1.5
Headache pain in last month	0.4	0.7	3.2	0.2	-0.4	-0.2	-1.8	-1.0	-0.5
Birth weight	0.4	0.8	1.8	-0.9	-1.3	0.1	-1.0	0.8	-0.7
Heart disease (mother)	0.4	0.5	1.3	1.1	0.7	0.1	1.0	0.2	0.7
Whole body fat mass	0.4	1.7	4.8	-1.3	-2.2	-0.9	0.0	-0.5	-1.7
Leg fat mass (right)	0.4	1.5	3.6	-1.2	-1.7	-0.8	0.0	-0.6	-1.9
Comparative height size at age 10	0.4	2.5	4.3	-1.6	-2.1	-0.3	1.8	0.9	-1.9
Illnesses of father: Heart disease	0.4	0.5	1.3	0.1	1.1	-0.7	0.4	0.6	-0.9
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.5	-0.8	-0.4	0.3	0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.8	-1.2	0.2	-0.7	1.7	-0.2	-0.4
Asthma (self-reported)	0.4	0.8	1.6	-0.4	-0.7	-1.0	-1.3	-1.2	-0.1
Medication: Aspirin	0.4	0.6	1.9	1.4	0.5	-0.2	-0.8	0.5	0.6
Ever taken oral contraceptive pill	0.4	0.5	1.4	-1.2	-0.3	1.0	-0.0	0.3	-0.3
Medication: Bendroflumethiazide	0.4	0.6	1.5	1.1	-0.1	0.1	-1.0	0.3	1.2
Medication: Paracetamol	0.4	0.6	1.8	-0.0	-1.1	-0.1	-1.3	-0.6	-0.1
Diastolic blood pressure, automated reading	0.4	1.1	3.5	1.1	0.2	-0.7	-0.1	1.9	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	0.7	-0.7	-1.1	0.7	0.5	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.6	1.5	-1.2	0.4	0.4	1.1	-0.2	-0.8
Alzheimer’s Disease (including proxy)	0.3	0.5	1.5	-1.2	0.5	0.3	0.6	-0.3	0.7
Bipolar Disorder (2011)	0.3	0.3	0.8	-0.9	-0.2	-0.1	0.5	0.1	-0.8
Schizophrenia (2014)	0.3	0.7	2.4	-0.0	0.9	1.5	-0.6	-0.1	0.6
Triglycerides	0.3	0.6	1.6	-0.9	-0.2	0.5	-0.0	-0.9	-1.2
BMI	0.3	1.6	4.2	-2.1	-1.1	0.2	-0.6	-1.2	-1.5
Waist Hip Ratio (WHR)	0.3	1.3	5.2	0.8	0.8	-0.3	1.0	0.4	2.3
Chronotype (morning person)	0.3	0.7	2.6	-0.1	-1.6	-0.9	0.3	-0.4	-0.8
Hand grip strength (left)	0.3	0.7	2.3	-0.8	-0.7	1.5	-0.7	-0.7	0.0
Age when periods started (menarche)	0.3	0.8	1.5	-0.5	1.2	-0.6	1.0	-0.5	1.2
High blood pressure	0.3	0.8	3.9	2.0	0.3	-0.6	-0.7	0.3	0.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.0	-0.2	0.2	-0.2	-1.1	-1.4	0.2
Waist circumference	0.3	1.1	3.1	-0.5	-1.8	-1.0	0.2	-0.5	-1.2
Had other major operations	0.3	0.4	1.8	0.6	-0.0	-1.3	-0.5	-0.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.4	0.7	0.0	1.6	0.3	1.2	0.1
Standing height	0.3	3.4	7.6	-1.2	-2.8	-1.5	1.7	-0.1	-2.5
Tense / ‘highly strung’	0.3	0.5	1.0	0.5	-0.8	0.7	-1.0	-0.8	0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	-0.2	0.6	1.1	0.3	-0.4	0.8
Wheeze or whistling in the chest in last year	0.3	0.5	2.1	-0.3	-0.6	-1.4	-0.3	-0.1	0.6
Age at first live birth	0.3	0.5	1.6	-0.2	0.8	-0.2	1.3	0.6	0.2
Health satisfaction	0.3	0.4	1.1	-0.2	-0.6	-0.1	-1.1	-0.8	0.2
Neck or shoulder pain in last month	0.3	0.5	1.3	1.1	-0.1	-0.6	-1.1	-0.1	0.3
Medication: Blood pressure	0.3	0.5	1.4	1.2	-0.8	-0.3	-0.9	0.1	-0.6
Alcohol intake frequency.	0.3	0.6	2.8	-0.2	-0.5	-1.7	0.2	0.2	0.7
Overall health rating	0.3	0.6	1.5	-0.3	-0.3	-1.2	-0.7	-1.0	-0.7
Leg pain on walking	0.3	0.4	1.4	-0.5	0.7	-0.0	0.0	-1.2	0.2
Qualifications: nursing, teaching	0.3	0.5	1.3	-1.1	0.5	0.3	0.0	-1.1	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.0	0.0	0.2	0.6	-1.0	0.2	0.7
Medication: Blood pressure	0.3	0.5	1.4	1.2	0.3	-0.9	0.1	0.2	0.6
Age started oral contraceptive pill	0.3	0.4	1.0	0.9	0.1	1.0	-0.7	-0.3	0.3
Commuting to job workplace: Cycle	0.3	0.4	1.3	-0.7	-0.0	1.2	-0.5	0.5	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.6	-1.9	-0.4	0.5	0.2	-0.5	-0.9
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.5	-1.2	0.4	0.1	-0.6	-1.1	0.6
Ulcerative Colitis (UC)	0.2	0.4	0.8	0.3	-0.9	0.8	0.4	0.8	-0.5
Reaction Time	0.2	0.4	1.2	0.5	0.1	0.8	-0.0	0.4	1.1
Rheumatoid Arthritis	0.2	0.2	0.5	0.3	0.6	-0.4	-0.1	0.7	0.3
Allergy or Eczema	0.2	0.5	1.4	-0.0	1.0	0.0	-1.2	-0.6	0.6
Trunk fat percentage	0.2	0.6	2.7	-0.5	-1.6	-0.1	-0.4	-0.1	-0.8
Hand grip strength (right)	0.2	0.6	2.4	-1.5	-0.5	0.5	0.0	-0.5	-0.5
Forced vital capacity (FVC)	0.2	0.8	1.8	-1.0	-1.4	1.0	-0.6	-0.6	-0.5
Illnesses of siblings	0.2	0.3	1.6	0.1	-0.2	1.2	-0.1	0.2	0.0
Arm fat percentage (right)	0.2	0.7	1.9	-1.4	-1.2	-0.2	-0.1	-0.7	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.7	-1.3	-0.7	0.8	-0.0	-0.8	-0.1
Exposure to tobacco smoke at home	0.2	0.3	0.9	0.1	-0.0	-0.1	-0.9	-0.9	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	-0.2	0.3	0.7	0.3	0.8	-0.5
Shortness of breath walking on level ground	0.2	0.2	0.7	-0.4	0.6	-0.8	0.2	-0.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	-0.4	0.3	0.1	0.8	0.3	0.5
Medication: Allopurinol	0.2	0.2	0.5	0.7	-0.6	0.2	-0.6	0.1	-0.3
Medication: Omeprazole	0.2	0.2	0.7	0.3	-0.8	0.2	-0.4	-0.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.6	0.4	-0.5	-0.8	0.5	0.2	-0.6
Medication: Aspirin	0.2	0.3	1.0	1.0	0.4	-0.3	-0.4	0.4	0.5
Knee pain experienced in last month	0.2	0.3	0.5	0.2	-0.7	-0.7	-0.6	0.2	-0.4
Hypertension (Self-reported)	0.2	0.6	2.5	1.6	0.1	-0.9	-0.4	0.1	0.2
Arm fat percentage (left)	0.2	0.9	2.0	-1.3	-1.4	-0.4	-0.1	-0.7	-1.0
Ever had bowel cancer screening	0.2	0.2	0.7	0.2	-0.8	0.3	0.4	0.3	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.6	0.0	-0.6	0.4	-1.3	-0.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	2.0	-0.8	-0.0	0.1	0.2	-1.4	0.5
Average weekly champagne plus white wine intake	0.2	0.3	1.2	0.5	-0.6	0.2	-1.1	0.1	-0.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.6	0.0	-0.4	-0.4	0.5	-0.6
Leg fat percentage (left)	0.2	0.7	1.5	0.1	-1.2	-0.2	-1.2	-0.1	-1.2
Myopia	0.2	0.3	0.9	-0.1	-0.6	-0.7	0.5	0.9	-0.3
Schizophrenia (2018)	0.1	0.3	0.4	0.6	0.5	0.2	0.6	0.4	-0.7
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	-0.6	-0.5	0.4	0.1	0.0	-0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.7	-0.4	0.3	-0.6	-0.1	-0.4
Blood Eosinophil Count	0.1	0.5	1.3	0.1	-1.1	-1.1	-0.4	0.1	0.8
Blood Platelet Count	0.1	1.0	2.5	-0.1	-0.3	0.1	-1.6	-1.6	-1.0
Blood Red Count	0.1	0.8	3.9	-2.0	-0.2	-0.2	0.7	-0.5	0.1
Cardiovascular Disease	0.1	0.3	1.0	0.5	0.1	-0.2	-0.5	-0.3	1.0
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.6	0.8	-0.7	0.0	-0.4	-0.3	0.6
Lung FEV1/FVC ratio	0.1	0.7	2.3	-0.6	0.9	-0.4	1.5	0.3	0.6
Hair Pigment	0.1	1.8	10.2	0.8	-0.1	0.3	0.2	3.2	-0.1
Tanning	0.1	1.2	2.8	-0.1	1.4	1.1	0.6	-1.7	1.0
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	-0.2	-0.3	-0.3	-0.3	-0.1	-0.4
Qualifications: None of the above	0.1	0.2	0.4	0.4	-0.5	0.4	0.3	0.6	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.4	-0.3	-0.2	0.6	-0.3	0.2	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.7	-0.8	0.0	0.5	0.2	-0.7	0.7
Medication: Paracetamol	0.1	0.2	0.6	0.1	-0.4	-0.7	-0.7	-0.3	0.0
Forced vital capacity (FVC), Best measure	0.1	0.4	1.1	-0.6	-0.6	0.6	-0.5	-1.0	-0.0
Body fat percentage	0.1	0.5	1.8	-0.5	-1.3	-0.1	-0.3	-0.1	-0.8
Leg fat percentage (right)	0.1	0.3	0.8	-0.1	-0.7	0.0	-0.6	-0.1	-0.9
Smoking status: Previous	0.1	0.1	0.2	-0.1	-0.3	0.1	-0.4	-0.2	0.4
Loneliness, isolation	0.1	0.1	0.4	0.4	-0.6	-0.2	-0.3	0.4	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	0.5	-0.2	-0.2	0.7	0.3	-0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.1	0.1	-0.3	0.3	0.2	0.3	-0.2	0.2
Father’s age at death	0.0	0.0	0.0	-0.2	0.1	0.0	0.2	-0.1	-0.2

Hub : Genes

CPNE5

Models

Trait associations