Best TWAS P=1.84e-24 · Best GWAS P=3.36e-25 conditioned to 0.000702
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | PBX3 | 0.11 | 0.07 | lasso | 2 | 0.06 | 8.1e-06 | 5.3 | 6.1 | 1.3e-09 | -0.53 | 0.62 | 0.05 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | MAPKAP1 | 0.04 | 0.03 | lasso | 3 | 0.02 | 6.5e-03 | -9.3 | -8.5 | 1.5e-17 | 0.86 | 0.07 | 0.88 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | PBX3 | 0.05 | 0.02 | enet | 7 | 0.00 | 1.4e-01 | -9.3 | 9.4 | 7.2e-21 | -0.91 | 0.07 | 0.83 | FALSE |
4 | GTEx | Colon Sigmoid | PBX3 | 0.23 | 0.22 | lasso | 3 | 0.16 | 1.9e-06 | 5.1 | 5.4 | 8.0e-08 | -0.45 | 0.93 | 0.01 | FALSE |
5 | GTEx | Colon Transverse | PBX3 | 0.11 | 0.01 | lasso | 3 | 0.02 | 5.6e-02 | 5.9 | 5.5 | 5.0e-08 | -0.46 | 0.12 | 0.29 | FALSE |
6 | GTEx | Esophagus Gastroesophageal Junction | PBX3 | 0.21 | 0.19 | lasso | 5 | 0.14 | 1.0e-05 | 5.9 | 5.9 | 3.3e-09 | -0.47 | 0.47 | 0.43 | FALSE |
7 | GTEx | Esophagus Muscularis | PBX3 | 0.12 | 0.08 | lasso | 7 | 0.09 | 4.2e-06 | 5.3 | 6.6 | 5.1e-11 | -0.55 | 0.94 | 0.05 | FALSE |
8 | GTEx | Heart Left Ventricle | PBX3 | 0.21 | 0.22 | lasso | 4 | 0.21 | 3.3e-11 | 5.1 | 5.1 | 2.7e-07 | -0.37 | 1.00 | 0.00 | FALSE |
9 | GTEx | Spleen | MAPKAP1 | 0.30 | 0.12 | lasso | 6 | 0.04 | 2.7e-02 | -9.6 | -8.5 | 1.5e-17 | 0.79 | 0.04 | 0.86 | FALSE |
10 | GTEx | Testis | PBX3 | 0.19 | 0.22 | lasso | 3 | 0.20 | 4.7e-09 | 4.8 | 5.6 | 2.4e-08 | -0.44 | 0.95 | 0.04 | FALSE |
11 | NTR | Blood | MAPKAP1 | 0.03 | 0.01 | blup | 441 | 0.02 | 2.3e-07 | -9.6 | -10.2 | 1.8e-24 | 0.83 | 0.19 | 0.81 | TRUE |
12 | ROSMAP | Brain Pre-frontal Cortex | SCAI | 0.02 | 0.00 | bslmm | 316 | 0.00 | 3.3e-01 | -7.9 | -5.4 | 6.8e-08 | 0.57 | 0.04 | 0.37 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PBX3 | 0.03 | 0.03 | blup | 65 | 0.04 | 5.4e-05 | 5.1 | 5.8 | 6.6e-09 | -0.44 | 0.46 | 0.51 | FALSE |