TWAS hub - MAPKAP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0440	0.0210	5.0e-03	0.031	NA	0.020	NA	0.024	2.1e-03	NA	0.01100	NA	6.5e-03
2	GTEx	Spleen	0.3040	0.1100	8.4e-04	0.124	NA	0.031	NA	0.044	4.5e-04	NA	0.05600	NA	2.7e-02
3	NTR	Blood	0.0262	0.0095	9.4e-07	0.013	0.021	0.013	0.02	0.011	2.4e-05	2.3e-07	0.00003	4.5e-07	8.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Pulse rate, automated reading	25.7	83.2	104.0	-8.5	-8.5	-10.2
Smoking Status	16.5	39.6	48.7	6.6	5.2	7.0
Smoking status: Current	14.4	22.9	26.3	4.9	4.3	5.1
Current tobacco smoking	14.2	23.2	26.7	4.9	4.4	5.2
Mother’s age at death	13.2	16.5	19.5	-3.8	-3.9	-4.4
Pulse rate	12.0	20.3	25.2	-4.1	-4.4	-5.0
Pulse wave reflection index	9.4	11.6	12.6	3.5	3.4	3.3
Osteoarthritis (self-reported)	9.3	12.0	14.8	3.3	3.2	3.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	8.8	10.4	12.9	3.6	2.7	3.3
Systolic Blood Pressure	8.6	43.3	54.5	-7.0	-5.1	-7.4
Townsend deprivation index at recruitment	8.2	11.5	13.6	3.3	3.2	3.7
Medication: Amlodipine	8.1	11.4	13.9	-3.6	-2.7	-3.7
Sensitivity / hurt feelings	7.9	13.5	15.8	3.8	3.2	4.0
Exposure to tobacco smoke outside home	7.6	10.1	13.3	2.8	3.6	3.0
Hand grip strength (right)	7.3	19.9	24.1	-4.9	-4.4	-4.0
Qualifications: O levels/GCSEs or equivalent	7.3	11.6	14.3	-3.2	-3.8	-3.2
Hand grip strength (left)	7.1	18.7	22.1	-4.7	-4.3	-3.9
Financial situation satisfaction	7.0	8.7	8.8	3.0	2.9	3.0
Emphysema/chronic bronchitis	6.7	7.5	8.0	2.7	2.8	2.6
Average weekly champagne plus white wine intake	6.2	8.6	10.7	-3.3	-2.3	-3.1
Pack years adult smoking proportion	6.1	9.3	11.4	2.9	2.8	3.4
Overall health rating	6.1	13.2	16.5	3.8	3.0	4.1
Medication for cholesterol, blood pressure or diabetes	5.9	9.8	12.8	3.5	2.2	3.6
Qualifications: nursing, teaching	5.9	9.2	13.3	-3.0	-3.6	-2.2
Unable to work because of sickness or disability	5.7	7.4	8.9	2.5	2.6	3.0
Myopia	5.6	8.2	11.0	-3.1	-3.3	-2.0
High blood pressure	5.5	15.5	20.2	-3.6	-3.6	-4.5
Hypertension (Self-reported)	5.4	15.1	21.3	-3.7	-3.2	-4.6
Cardiovascular Disease	5.3	17.6	23.6	-4.2	-3.4	-4.9
Alcohol usually taken with meals	5.3	8.6	10.1	-3.2	-3.0	-2.6
Medication: Blood pressure	5.2	9.2	11.7	-3.3	-2.3	-3.4
Heart attack	5.1	6.5	8.6	1.8	2.8	2.9
Heart attack/myocardial infarction (self-reported)	5.1	6.6	8.4	1.9	2.8	2.9
Systolic blood pressure, automated reading	5.0	14.6	22.6	-3.9	-2.5	-4.8
Past tobacco smoking	5.0	9.2	10.7	-3.2	-2.6	-3.3
Illnesses of father: High blood pressure	5.0	6.2	7.5	-2.7	-2.0	-2.7
Age started oral contraceptive pill	5.0	6.3	6.4	-2.5	-2.5	-2.5
Maternal smoking around birth	4.8	6.9	9.3	3.0	1.5	3.0
Mouth/teeth dental problems: Dentures	4.8	8.0	11.4	2.6	3.4	2.5
Medication: Seretide 50 evohaler	4.7	5.4	9.3	2.0	1.7	3.0
Ever smoked	4.7	8.2	9.4	3.1	2.5	3.0
High blood pressure (mother)	4.6	6.5	7.5	-2.4	-2.7	-2.5
Leg fat percentage (left)	4.6	16.7	20.1	4.1	3.6	4.5
Falls in the last year	4.5	6.0	7.1	2.2	2.7	2.4
Qualifications: None of the above	4.4	9.5	13.7	3.7	3.1	2.4
Leg fat percentage (right)	4.3	15.7	17.8	4.2	3.4	4.2
Diastolic blood pressure, automated reading	4.3	13.2	19.9	-3.1	-3.1	-4.5
Pain all over the body in last month	4.2	4.5	9.0	1.8	1.1	3.0
Fractured/broken bones in last 5 years	4.2	5.4	7.1	2.4	2.7	1.9
Financial difficulties in last 2 years	4.1	5.5	9.2	2.3	1.4	3.0
Pack years of smoking	4.1	6.1	6.6	2.6	2.3	2.6
Vascular/heart problems diagnosed by doctor	4.0	10.9	15.2	3.0	2.9	3.9
Medication: Ventolin 100micrograms inhaler	3.8	4.9	6.8	2.0	2.6	2.0
Diabetes (father)	3.7	4.6	8.5	-2.9	-2.1	-0.8
Qualifications: College or University degree	3.7	11.7	14.2	-3.5	-3.8	-3.0
Average weekly red wine intake	3.7	5.5	7.6	-1.9	-2.8	-2.3
Sitting height	3.6	25.5	26.1	-5.1	-5.1	-5.0
Knee pain experienced in last month	3.6	5.7	7.4	2.7	2.6	1.7
Wears glasses or contact lenses	3.6	4.1	4.2	-2.0	-2.0	-2.0
Schizophrenia vs Biploar Disorder	3.5	4.6	6.1	-1.8	-2.5	-2.1
Blood clot in the leg (DVT)	3.5	4.5	6.6	1.8	2.6	1.8
Chronic bronchitis/emphysema (mother)	3.5	4.0	4.9	2.0	1.8	2.2
Mouth/teeth dental problems: Loose teeth	3.5	4.2	5.4	2.3	1.6	2.1
Qualifications: A levels/AS levels or equivalent	3.4	7.6	10.6	-2.8	-3.3	-2.1
Mouth/teeth dental problems: Bleeding gums	3.4	4.4	5.6	-2.4	-1.8	-2.1
Deep venous thrombosis (DVT) (self-reported)	3.3	4.2	7.3	1.7	2.7	1.6
Age at First Birth	3.2	4.7	6.5	-2.5	-2.1	-1.8
Health satisfaction	3.2	4.2	6.6	2.0	1.5	2.6
Serious illness, injury or assault to yourself	3.1	3.7	5.1	1.8	2.3	1.7
Happiness	3.1	3.8	4.3	1.7	2.0	2.1
Standing height	3.1	30.5	33.3	-5.8	-5.4	-5.4
Ever depressed for a whole week	3.1	3.8	5.6	2.4	1.6	1.8
Irritability	3.0	5.0	7.6	-2.8	-1.4	-2.3
Body fat percentage	2.9	11.6	15.1	3.4	2.9	3.9
Heart disease (mother)	2.9	3.5	3.8	1.8	1.8	2.0
Height	2.8	53.6	61.0	-7.8	-7.0	-7.2
Mean time to correctly identify matches	2.8	5.3	7.4	-2.4	-1.6	-2.7
Comparative height size at age 10	2.8	15.5	17.7	-4.2	-3.7	-3.8
Waist Hip Ratio (WHR)	2.7	12.0	16.2	4.0	2.8	3.4
Birth weight of first child	2.7	4.9	6.5	-1.9	-2.2	-2.6
Long-standing illness, disability or infirmity	2.7	4.1	7.1	1.6	1.6	2.7
Bipolar Disorder (2018)	2.6	4.2	6.0	1.6	2.4	2.0
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	3.4	1.8	1.3	1.8
LDL Cholesterol	2.5	3.9	5.3	2.1	2.3	1.4
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	3.9	2.0	1.5	1.4
Arm fat percentage (right)	2.5	9.9	13.5	3.0	2.6	3.7
Ulcerative Colitis	2.4	3.4	4.9	-2.2	-1.9	-1.4
Waist circumference	2.4	8.7	10.8	3.1	2.4	3.3
Family relationship satisfaction	2.4	2.9	4.2	1.5	1.5	2.1
Arm fat percentage (left)	2.4	9.8	13.8	3.0	2.6	3.7
Reaction Time	2.3	4.4	7.1	-2.0	-1.4	-2.7
Blood Red Count	2.3	22.1	27.4	5.2	3.6	5.1
Trunk fat-free mass	2.3	13.3	15.2	-3.9	-3.5	-3.5
Trunk predicted mass	2.3	13.1	15.1	-3.9	-3.5	-3.5
Ulcerative Colitis (UC)	2.2	4.1	4.8	-2.2	-1.7	-2.2
Supplements: Glucosamine	2.2	2.9	4.0	1.4	1.7	2.0
Forced expiratory volume in 1-second (FEV1)	2.2	7.5	11.2	-3.4	-2.9	-1.8
Chronic bronchitis/emphysema (father)	2.1	2.5	3.1	1.8	1.1	1.8
Headache pain in last month	2.1	3.7	6.0	-1.3	-1.9	-2.4
Birth weight	2.1	4.6	5.6	-2.4	-2.0	-2.1
Commuting to job workplace: Public transport	2.1	2.5	3.1	-1.8	-1.6	-1.4
Medication: Blood pressure	2.1	4.0	5.3	-2.3	-1.4	-2.2
Major Depression (MDD)	2.0	2.4	4.5	2.1	1.2	1.2
Age when periods started (menarche)	2.0	4.8	6.2	2.4	2.5	1.6
Alcohol intake frequency.	2.0	4.6	8.1	1.7	1.6	2.9
Age at last live birth	2.0	2.9	4.2	-1.4	-2.1	-1.5
Asthma (self-reported)	2.0	4.0	5.9	1.5	2.0	2.4
Risk taking	2.0	2.9	3.6	-1.2	-1.9	-1.9
Respiratory disease	1.9	4.2	7.1	1.5	1.8	2.7
Trunk fat percentage	1.9	7.6	10.4	2.7	2.3	3.2
Father’s age at death	1.9	2.6	3.2	-1.5	-1.8	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	3.7	1.3	1.3	1.9
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	4.0	-1.4	-1.0	-2.0
Whole body fat-free mass	1.9	10.8	12.5	-3.5	-3.4	-2.9
Medication: Paracetamol	1.8	2.9	4.1	2.0	1.3	1.8
Smoking status: Previous	1.8	2.8	3.9	1.5	1.4	2.0
Friendships satisfaction	1.8	2.3	2.7	1.4	1.5	1.6
Illnesses of father: None of the above (group 1)	1.8	2.2	3.9	2.0	0.9	1.3
Whole body water mass	1.8	10.5	12.0	-3.5	-3.3	-2.9
Average weekly spirits intake	1.7	2.1	4.0	2.0	1.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.3	7.6	-2.8	-2.1	-1.9
Leg fat mass (right)	1.7	6.4	9.0	2.5	2.0	3.0
Osteoporosis (self-reported)	1.7	2.1	2.7	1.0	1.6	1.6
Medication: Bendroflumethiazide	1.7	2.6	3.2	-1.8	-1.6	-1.4
Ever had prostate specific antigen (PSA) test	1.7	2.0	2.4	-1.5	-1.2	-1.6
Leg fat mass (left)	1.7	6.7	9.5	2.5	2.1	3.1
Peak expiratory flow (PEF)	1.6	3.6	7.2	-2.7	-1.7	-0.8
Shortness of breath walking on level ground	1.6	1.9	4.7	0.3	2.2	0.9
Commuting to job workplace: Walk	1.6	1.8	4.2	-2.0	-0.3	-1.0
Back pain experienced in last month	1.6	2.4	3.9	2.0	1.7	0.7
Medication: Lisinopril	1.6	2.1	3.0	-1.7	-1.6	-1.0
Heel T-Score	1.5	11.7	19.3	-3.2	-4.4	-2.4
BMI	1.5	8.9	11.4	2.6	3.0	3.4
Tanning	1.5	17.8	19.9	4.5	4.1	4.1
Body mass index (BMI)	1.5	6.3	9.9	2.3	1.9	3.1
Mouth/teeth dental problems	1.5	2.3	2.6	-1.4	-1.6	-1.5
Asthma	1.5	3.0	4.4	1.1	1.8	2.1
High blood pressure (siblings)	1.5	2.2	3.5	-1.9	-0.9	-1.5
Alzheimer’s Disease (in mother)	1.4	1.6	2.2	-1.4	-0.7	-1.5
Primary Biliary Cirrhosis	1.4	2.0	3.1	1.0	1.8	1.4
Number of incorrect matches in round	1.4	2.4	4.0	2.0	1.4	1.1
Hearing difficulty/problems with background noise	1.4	2.2	2.5	1.5	1.6	1.4
Had other major operations	1.4	1.7	1.9	1.4	1.1	1.4
Allergy	1.4	3.3	4.5	-1.3	-2.1	-1.9
Medication: Cholesterol lowering	1.4	2.1	3.2	-1.7	-0.4	-1.8
Ever highly irritable/argumentative for 2 days	1.4	1.6	2.5	1.2	1.6	0.9
Leg pain on walking	1.4	1.7	3.3	0.8	1.2	1.8
Relative age of first facial hair	1.3	2.7	4.3	2.1	1.7	0.9
Relative age voice broke	1.3	2.0	2.2	1.5	1.5	1.3
Medication: Lansoprazole	1.3	1.5	1.8	1.2	1.2	1.3
Lung cancer (father)	1.3	1.5	2.1	1.5	1.2	1.1
Arm fat-free mass (right)	1.3	6.7	7.4	-2.7	-2.7	-2.3
Arm fat-free mass (left)	1.3	6.6	7.8	-2.6	-2.8	-2.4
Leg fat-free mass (left)	1.2	6.2	7.6	-2.8	-2.7	-1.9
Leg predicted mass (left)	1.2	6.3	7.9	-2.8	-2.7	-1.9
Nervous feelings	1.2	2.3	5.6	1.1	0.4	2.4
Forced vital capacity (FVC)	1.2	4.7	6.9	-2.6	-2.6	-0.8
Arm predicted mass (right)	1.2	6.3	7.1	-2.7	-2.6	-2.3
Leg fat-free mass (right)	1.2	6.5	8.8	-3.0	-2.8	-1.8
Ever had bowel cancer screening	1.2	1.4	3.2	-0.4	-1.0	-1.8
Basal metabolic rate	1.2	6.6	7.7	-2.8	-2.8	-2.1
Arm predicted mass (left)	1.2	6.0	6.8	-2.5	-2.6	-2.2
Hair/balding pattern: Pattern 2	1.1	1.4	3.4	-0.9	-0.0	-1.9
Depression (self-reported)	1.1	1.3	1.7	1.0	1.0	1.3
Tense / ‘highly strung’	1.1	1.8	3.9	-2.0	-1.0	-0.8
Leg predicted mass (right)	1.1	6.1	8.5	-2.9	-2.7	-1.7
Medication: Paracetamol	1.1	1.7	2.8	1.7	1.3	0.8
Supplements: Zinc	1.0	1.1	2.1	-1.2	-0.0	-1.4
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.1	-0.6	-1.4	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	1.9	1.2	1.2	1.4
Forced vital capacity (FVC), Best measure	1.0	3.8	5.4	-2.3	-2.2	-1.1
Comparative body size at age 10	1.0	2.9	3.7	1.7	1.4	1.9
Number of full brothers	1.0	1.3	1.6	1.3	1.0	1.1
Number of children fathered	1.0	1.1	2.1	1.5	0.6	0.9
Medication: Ibuprofen	1.0	1.2	1.9	-1.1	-0.7	-1.4
Suffer from ‘nerves’	1.0	1.5	2.9	0.9	0.9	1.7
Guilty feelings	1.0	1.5	2.9	1.1	0.6	1.7
Bipolar Disorder or Schizophrenia	0.9	2.3	5.1	1.1	2.3	0.8
Mean Putamen Volume	0.9	1.1	1.2	0.9	1.1	1.1
Noisy workplace	0.9	1.1	2.3	0.3	1.5	0.9
Wheeze or whistling in the chest in last year	0.9	1.6	1.9	1.4	1.1	1.3
Whole body fat mass	0.9	4.0	6.6	1.9	1.4	2.6
Loneliness, isolation	0.9	1.3	1.9	1.4	0.5	1.3
Alcohol drinker status: Never	0.9	1.1	1.6	0.9	1.3	0.8
Bipolar Disorder (2011)	0.8	0.8	1.4	-0.9	-0.1	-1.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	1.4	0.6	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.5	0.8	1.1	1.2
Stomach or abdominal pain in last month	0.8	1.0	1.9	-0.5	0.8	-1.4
Medication for pain relief, constipation, heartburn	0.8	1.3	1.8	-1.3	-1.2	-0.8
Had major operations	0.8	1.0	1.6	-1.2	-1.3	-0.2
High cholesterol (Self-reported)	0.8	1.4	3.1	-1.0	-0.3	-1.8
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.3	-1.5	-0.9	-1.3
Medication: Ramipril	0.7	0.9	2.4	-0.5	1.6	-0.1
Illnesses of siblings	0.7	1.0	1.4	0.9	0.9	1.2
Prospective memory result	0.7	0.9	1.9	0.3	1.4	0.8
Arm fat mass (right)	0.7	2.9	5.4	1.4	1.2	2.3
Hair/balding pattern: Pattern 4	0.7	1.7	3.2	1.0	1.8	0.9
Medication: Allopurinol	0.7	1.0	2.0	0.8	1.4	0.6
Arm fat mass (left)	0.7	2.8	5.1	1.5	1.1	2.3
Eye problems/disorders: Glaucoma	0.7	0.8	1.4	0.6	-1.2	-0.8
Alzheimer’s Disease (including proxy)	0.6	0.9	1.6	-0.7	-0.8	-1.3
Lupus	0.6	1.0	1.4	0.8	0.9	1.2
Hearing difficulty/problems: Yes	0.6	1.0	1.6	0.8	1.2	0.9
Impedance of leg (left)	0.6	3.0	3.7	1.9	1.9	1.3
Trunk fat mass	0.6	2.5	4.2	1.4	1.2	2.1
Medication: Simvastatin	0.6	0.8	2.1	-0.5	-0.3	-1.5
Alcohol intake versus 10 years previously	0.6	0.9	1.2	-1.1	-0.9	-0.7
Worrier / anxious feelings	0.6	1.0	1.7	-1.3	-0.7	-1.0
Breastfed as a baby	0.6	0.7	1.6	-0.6	-1.3	-0.5
Pulse wave peak to peak time	0.6	0.7	1.5	-1.2	-0.7	-0.2
Number of self-reported non-cancer illnesses	0.6	1.1	1.3	1.0	1.1	1.1
Miserableness	0.6	1.0	2.4	0.1	0.8	1.5
Hearing aid user	0.6	0.7	1.8	-1.3	-0.2	-0.5
Commuting to job workplace: Cycle	0.6	0.8	0.9	-0.8	-0.9	-0.9
Neuroticism (Nagel 2018)	0.5	1.1	2.4	0.5	0.7	1.6
Irritable Bowel Disease (IBD)	0.5	1.2	1.5	-1.2	-0.8	-1.2
Lung FEV1/FVC ratio	0.5	2.7	6.1	-1.4	-0.2	-2.5
Ever had hysterectomy (womb removed)	0.5	0.6	1.2	0.4	1.1	0.6
Angina	0.5	0.6	1.3	0.2	1.1	0.8
Medication for hormone replacement therapy	0.5	0.6	1.4	0.4	0.4	1.2
Vitamin and mineral supplements	0.5	0.7	2.1	-0.1	-1.4	-0.2
Qualifications: CSEs or equivalent	0.5	0.7	1.3	-0.9	0.2	-1.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.4	-0.6	-0.4	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.7	-0.8	-0.8	-0.9
Illnesses of mother	0.5	0.7	1.0	0.8	0.7	1.0
Gout (self-reported)	0.5	0.7	1.3	0.2	1.1	0.9
Age at first live birth	0.5	0.9	1.3	-0.9	-1.1	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	-0.4	-1.3	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.7	0.1	1.3	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.2	1.1	0.1	0.7
Mineral and other dietary supplements	0.5	0.6	1.8	-0.1	-1.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.6	-1.2	-0.5	-1.3
Alzheimer’s Disease (in father)	0.4	0.4	0.6	-0.7	-0.4	-0.8
Triglycerides	0.4	0.6	1.6	1.3	0.3	0.2
Blood White Count	0.4	2.9	7.8	1.0	0.2	2.8
Medication: Co-codamol	0.4	0.4	1.0	0.5	-0.1	1.0
Impedance of leg (right)	0.4	1.9	3.0	1.7	1.5	0.7
Multivitamins +/- minerals	0.4	0.5	1.3	0.1	1.1	0.4
Medication: Levothyroxine sodium	0.4	0.7	1.3	0.8	0.4	1.2
Had menopause	0.4	0.5	0.9	0.9	-0.2	0.7
Number of live births	0.4	0.6	1.7	1.3	0.3	-0.2
Glaucoma (self-reported)	0.4	0.5	1.4	1.2	-0.3	-0.2
Worry too long after embarrassment	0.4	0.6	0.9	0.6	0.8	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.6	-0.8	-0.3	-0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	0.3	-0.8	0.9
Medication: Aspirin	0.4	0.5	1.0	-0.6	0.3	-1.0
Ever taken oral contraceptive pill	0.4	0.4	0.9	0.6	0.3	1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	0.6	0.9	0.4
Average weekly beer plus cider intake	0.4	0.6	1.0	1.0	0.8	0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	1.0	0.5	0.6
Supplements: Calcium	0.4	0.4	0.7	0.1	0.8	0.8
Depression (Nagel 2018)	0.3	0.4	0.6	0.7	0.4	0.7
HDL Cholesterol	0.3	0.5	0.8	-0.9	0.2	-0.8
Schizophrenia (2014)	0.3	0.6	1.5	0.3	1.2	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.8	-0.4	-0.9	-0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.7	0.2	0.1	1.3
Neuroticism	0.3	0.7	1.2	0.4	1.1	0.8
Medication: Metformin	0.3	0.5	0.7	-0.8	-0.9	0.2
Taking other prescription medications	0.3	0.4	1.1	0.4	-0.0	1.1
Medication: Atenolol	0.3	0.4	0.6	-0.8	0.3	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.0	0.1	1.0	0.5
Pulse wave Arterial Stiffness index	0.3	0.4	0.9	1.0	0.5	-0.1
Length of working week for main job	0.3	0.3	0.7	-0.3	-0.9	-0.2
Angina (self-reported)	0.3	0.4	1.0	0.0	1.0	0.3
Medication: Omeprazole	0.3	0.4	0.7	0.8	0.6	0.4
Number of full sisters	0.3	0.4	0.8	0.9	-0.4	-0.3
Illnesses of father: Heart disease	0.3	0.4	1.0	-1.0	-0.2	-0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	0.2	0.9	-0.5
Number of operations (self-reported)	0.3	0.4	0.5	0.6	0.7	0.6
Pain experienced in last month	0.3	0.4	0.8	-0.6	-0.9	0.3
Impedance of whole body	0.3	1.5	1.7	1.3	1.2	1.1
Depressed Affect (Nagel 2018)	0.2	0.4	1.0	0.1	0.3	1.0
Schizophrenia (2018)	0.2	0.4	0.9	0.1	0.9	-0.7
Crohns Disease (2017)	0.2	0.3	0.6	0.4	0.8	0.6
Coronary Artery Disease (CAD)	0.2	0.2	0.4	0.5	0.7	-0.0
Crohns Disease (2012)	0.2	0.3	0.4	0.4	0.5	0.6
Fasting Glucose	0.2	0.3	0.8	0.9	0.2	0.0
HbA1C	0.2	0.2	0.5	0.7	0.2	-0.1
Neuroticism (2016)	0.2	0.3	0.6	0.4	-0.2	0.8
Hypothyroidism (self reported)	0.2	0.4	1.0	0.1	-0.5	1.0
Number of treatments/medications taken	0.2	0.4	1.0	-0.3	1.0	0.2
Diabetes (mother)	0.2	0.3	0.8	-0.3	-0.9	0.1
Severe depression (siblings)	0.2	0.2	0.6	0.1	0.8	-0.3
Average weekly fortified wine intake	0.2	0.3	0.5	0.4	0.3	0.7
Fed-up feelings	0.2	0.4	1.1	0.1	0.2	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.3	-0.4	-1.1	-0.3
Diabetes (self-reported)	0.2	0.2	0.6	-0.8	-0.2	0.3
Impedance of arm (right)	0.2	0.7	1.0	0.7	0.9	1.0
Impedance of arm (left)	0.2	0.8	1.2	0.7	0.9	1.1
Exposure to tobacco smoke at home	0.2	0.3	0.6	0.4	0.8	0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	0.8	0.4	0.3
Medication: Aspirin	0.2	0.3	0.6	-0.4	0.4	-0.8
Supplements: Vitamin C	0.2	0.2	0.3	-0.2	0.6	-0.5
Illnesses of siblings: Diabetes	0.2	0.3	0.4	0.7	-0.2	0.6
Breast cancer (self-reported)	0.2	0.2	0.5	0.5	-0.7	-0.2
Medication: Atorvastatin	0.2	0.2	0.6	-0.8	-0.2	-0.0
Alcohol drinker status: Previous	0.2	0.2	0.5	-0.0	-0.0	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	-0.6	-0.5	-0.4
Worry (Nagel 2018)	0.1	0.1	0.3	-0.5	-0.1	0.0
Breast Cancer	0.1	0.2	0.2	0.4	-0.5	0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.5	0.0	-0.5
Blood Eosinophil Count	0.1	0.7	1.8	-1.3	-0.6	0.2
Blood Platelet Count	0.1	1.2	2.2	1.1	-0.1	1.5
Allergy or Eczema	0.1	0.3	0.6	-0.2	0.8	-0.4
Chronotype (morning person)	0.1	0.3	0.4	-0.6	0.6	-0.3
Hair Pigment	0.1	2.0	2.6	-1.6	-1.6	-1.0
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	-0.5	-0.2	-0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.3	0.2	-0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.5	0.5	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.8	0.4	-0.9	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	-0.1	0.5	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	-0.3	0.2	-0.3
Neuroticism score	0.1	0.1	0.3	-0.2	0.3	0.5
Weight	0.1	0.3	0.4	-0.3	-0.6	0.6
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.2	-0.1	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.5	-0.1	0.4
Loud music exposure frequency	0.1	0.1	0.3	0.1	0.2	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	0.0	-0.3	0.7
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.3	-0.3	0.4
Neck or shoulder pain in last month	0.1	0.2	0.5	-0.1	0.0	0.7
Migraine (self-reported)	0.1	0.1	0.2	-0.5	-0.3	-0.1
Chest pain or discomfort	0.1	0.1	0.3	0.1	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	-0.2	0.5	0.6
Mood swings	0.1	0.2	0.5	-0.1	0.1	0.7
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.1	0.1	0.8
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.1	-0.4	-0.4
Medication for cholesterol	0.1	0.1	0.2	0.4	-0.2	-0.1
Medication: Gliclazide	0.1	0.1	0.1	0.3	-0.3	0.2
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.2	-0.5	-0.3
Heart disease (siblings)	0.1	0.1	0.2	0.2	0.3	-0.4
Ovarian Cancer	0.0	0.1	0.1	0.3	0.2	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.1	0.1	-0.1	0.4	-0.0
Lung FVC	0.0	0.2	0.5	-0.0	-0.4	0.7
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	0.1	0.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	-0.1	0.2	0.4
Fluid intelligence score	0.0	0.1	0.2	0.1	-0.2	0.4
Hip circumference	0.0	0.2	0.3	0.1	-0.4	0.6
Time employed in main current job	0.0	0.0	0.1	-0.1	0.0	-0.3
Eye problems/disorders: Cataract	0.0	0.0	0.0	-0.1	0.1	-0.0
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	-0.2	0.0	-0.2
Cholesterol lowering medication	0.0	0.1	0.2	0.1	0.4	-0.1

Hub : Genes

MAPKAP1

Models

Trait associations