Best TWAS P=1.1e-15 · Best GWAS P=1.26e-80 conditioned to 2.2e-74
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | SSPN | 0.16 | 0.06 | lasso | 7 | 0.07 | 1.1e-06 | 7.2 | -5.6 | 1.8e-08 | -0.03 | 0.00 | 1.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | RP11-283G6.5 | 0.13 | 0.04 | lasso | 7 | 0.02 | 5.8e-03 | 7.2 | -5.4 | 6.5e-08 | 0.00 | 0.01 | 0.98 | FALSE |
3 | GTEx | Artery Aorta | SSPN | 0.16 | 0.00 | lasso | 2 | 0.00 | 5.2e-01 | 7.2 | -7.3 | 3.3e-13 | 0.06 | 0.00 | 0.99 | FALSE |
4 | GTEx | Artery Tibial | SSPN | 0.17 | 0.05 | enet | 13 | 0.06 | 1.1e-05 | 2.4 | -5.7 | 9.7e-09 | -0.01 | 0.01 | 0.99 | FALSE |
5 | GTEx | Artery Tibial | RP11-283G6.5 | 0.13 | 0.01 | enet | 15 | 0.01 | 2.9e-02 | 7.2 | -6.3 | 3.7e-10 | 0.00 | 0.01 | 0.93 | FALSE |
6 | GTEx | Breast Mammary Tissue | SSPN | 0.27 | 0.00 | lasso | 9 | 0.02 | 4.1e-02 | 7.3 | -8.0 | 1.1e-15 | 0.00 | 0.00 | 0.98 | TRUE |
7 | GTEx | Breast Mammary Tissue | RP11-283G6.5 | 0.17 | 0.02 | enet | 9 | 0.02 | 2.9e-02 | 7.3 | -6.0 | 1.8e-09 | -0.01 | 0.01 | 0.91 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | SSPN | 0.14 | 0.07 | enet | 15 | 0.16 | 3.1e-12 | 7.2 | -5.7 | 9.6e-09 | 0.05 | 0.00 | 1.00 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | RP11-283G6.5 | 0.16 | 0.05 | enet | 14 | 0.15 | 2.2e-11 | 7.2 | -5.7 | 1.2e-08 | 0.05 | 0.00 | 1.00 | FALSE |
10 | GTEx | Heart Atrial Appendage | SSPN | 0.27 | 0.00 | enet | 4 | 0.01 | 1.2e-01 | 7.2 | -7.1 | 9.4e-13 | 0.03 | 0.02 | 0.79 | FALSE |
11 | GTEx | Heart Atrial Appendage | RP11-283G6.5 | 0.27 | -0.01 | enet | 8 | 0.02 | 4.5e-02 | 2.4 | -5.6 | 2.5e-08 | -0.01 | 0.03 | 0.65 | FALSE |
12 | GTEx | Nerve Tibial | SSPN | 0.18 | 0.07 | lasso | 7 | 0.07 | 7.3e-06 | 7.2 | -5.8 | 8.4e-09 | 0.00 | 0.00 | 1.00 | FALSE |
13 | GTEx | Testis | BCAT1 | 0.41 | 0.10 | enet | 45 | 0.21 | 7.2e-10 | 5.8 | -7.2 | 4.4e-13 | 0.13 | 0.80 | 0.14 | TRUE |