Hub : Genes

BCAT1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1460 0.0380 1.6e-05 0.059 0.059 0.078 0.085 0.055 9.7e-08 9.8e-08 9.7e-10 1.5e-10 2.8e-07
2 GTEx Cells Transformed fibroblasts 0.1590 0.0490 2.0e-03 0.103 NA 0.039 NA 0.075 3.8e-08 NA 5.9e-04 NA 3.0e-06
3 GTEx Nerve Tibial 0.3286 0.0667 2.9e-05 0.165 NA 0.172 NA 0.179 8.8e-12 NA 2.9e-12 NA 9.9e-13
4 GTEx Testis 0.4100 0.0780 3.5e-07 0.103 NA 0.214 NA 0.188 2.5e-05 NA 7.2e-10 NA 9.5e-09
5 METSIM Adipose 0.0805 0.0248 1.2e-04 0.001 0.035 0.023 0.036 0.014 2.2e-01 4.6e-06 1.8e-04 3.9e-06 3.1e-03
6 NTR Blood 0.2545 0.0313 0.0e+00 0.122 0.108 0.142 0.135 0.141 3.8e-37 4.4e-33 1.4e-43 2.8e-41 3.8e-43
7 ROSMAP Brain Pre-frontal Cortex 0.2233 0.0399 9.8e-12 0.118 0.095 0.139 0.143 0.152 6.1e-15 3.1e-12 1.9e-17 6.5e-18 4.5e-19
8 YFS Blood 0.6862 0.0270 0.0e+00 0.305 0.447 0.517 0.524 0.471 5.6e-102 1.0e-164 1.1e-201 8.9e-206 7.7e-177

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 1.8 2.8 6.0 0.2 -2.1 -1.6 -2.4 -1.4 1.6 -0.9 2.1
Bipolar Disorder or Schizophrenia 1.5 3.8 8.4 -0.5 -1.3 -2.9 -2.6 -1.9 1.8 -0.4 2.4
Depressed Affect (Nagel 2018) 0.3 0.6 2.1 -0.2 -0.7 0.6 0.2 -0.3 1.5 0.3 1.1
Depression (Nagel 2018) 0.9 1.4 4.2 0.6 0.5 0.7 2.1 1.6 1.4 0.6 0.8
Intelligence (Savage-Jansen 2018) 0.3 1.0 2.0 0.6 0.9 1.4 1.2 0.2 -1.3 0.6 -1.1
Neuroticism (Nagel 2018) 0.5 1.2 4.1 -0.2 -2.0 -0.5 -0.0 0.7 1.7 -0.4 1.3
Schizophrenia (2018) 0.8 1.7 6.0 -0.9 0.1 -2.5 -1.3 -1.2 1.1 0.2 1.5
Schizophrenia vs Biploar Disorder 0.6 0.7 1.8 0.1 1.1 -0.4 -0.4 1.4 1.0 -0.3 1.2
Worry (Nagel 2018) 1.1 2.3 6.4 -0.3 -1.6 -0.2 0.1 2.1 2.5 -0.2 2.2
Alzheimer’s Disease (in mother) 0.4 0.5 2.6 -0.2 -1.6 0.2 0.5 -0.4 0.3 -0.5 -0.6
Alzheimer’s Disease (in father) 0.7 0.8 1.7 -0.7 -0.8 0.4 -0.9 0.7 -1.3 -0.9 -1.1
Alzheimer’s Disease (including proxy) 0.4 0.6 2.3 -0.7 -1.5 0.7 0.1 0.4 -0.4 -0.9 -0.7
Crohns Disease (2017) 0.1 0.1 0.5 -0.3 -0.1 -0.4 -0.5 -0.7 0.0 0.1 -0.2
Irritable Bowel Disease (IBD) 0.1 0.4 0.9 -0.9 -0.5 -0.9 -0.3 -0.8 0.2 0.4 0.1
Ulcerative Colitis (UC) 0.2 0.3 1.3 -0.6 -0.2 -1.1 0.2 -0.3 -0.3 0.6 0.1
Major Depression (MDD) 1.1 1.3 6.0 0.2 -0.9 -0.1 -0.2 0.3 -1.7 -0.6 -2.5
Reaction Time 0.6 1.1 2.5 1.3 -1.1 -1.4 0.1 1.6 0.9 -0.4 0.8
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.6 1.3 1.1 1.1 0.4 0.4 -1.2 0.1 -0.8
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.2 0.2 1.0 -0.5 0.2 0.3 0.0 1.0 0.2 -0.3 0.6
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.7 1.1 5.1 -1.2 0.3 0.1 1.2 -2.3 -0.2 0.0 -0.7
Bipolar Disorder (2011) 0.8 0.8 1.9 -1.0 -0.7 -0.9 -1.4 -1.0 -0.6 -0.4 0.1
Body Mass Index (BMI) (2010) 0.5 0.7 2.1 -0.2 -0.6 0.9 0.1 0.9 -1.4 -1.0 -0.5
Coronary Artery Disease (CAD) 0.6 0.7 2.1 -0.6 -0.7 -1.5 0.3 1.2 0.3 0.7 0.5
Crohns Disease (2012) 0.1 0.2 0.9 -0.5 0.1 -0.3 -0.5 -0.2 0.9 0.2 -0.3
Mean Putamen Volume 0.4 0.5 0.9 0.5 0.9 -0.6 -0.9 0.4 0.8 0.7 0.3
Fasting Glucose 1.5 1.8 6.7 -0.6 0.3 -1.2 -0.1 -0.8 -2.3 -0.2 -2.6
HbA1C 1.1 1.3 6.1 0.2 -1.5 -2.5 -0.8 -0.2 -0.5 0.0 -0.9
HDL Cholesterol 0.5 0.8 3.1 -0.4 -1.8 -0.4 -0.7 -0.4 -0.2 -1.4 0.2
LDL Cholesterol 1.0 1.6 7.2 -0.1 -2.7 -0.7 0.2 1.6 0.9 1.1 -0.3
Lupus 0.8 1.2 3.0 -1.6 0.2 1.7 -0.2 0.8 1.1 0.2 1.4
Neuroticism (2016) 0.6 0.9 2.2 -0.1 -1.0 1.3 0.4 1.3 -0.3 -1.5 -0.4
Primary Biliary Cirrhosis 1.0 1.4 4.6 0.5 1.1 1.1 2.1 1.5 -0.6 0.6 -1.0
Rheumatoid Arthritis 0.7 1.0 2.3 -0.4 1.2 -1.0 -1.5 -0.8 0.3 -1.2 0.6
Schizophrenia (2014) 1.0 2.2 5.6 -0.8 1.0 -2.1 -2.4 -1.1 1.1 -0.8 1.8
Triglycerides 0.2 0.4 1.3 -0.4 -0.6 -0.7 0.4 0.1 0.8 1.2 -0.0
Type 2 Diabetes (T2D) (2012) 0.6 0.6 2.3 -0.6 0.4 0.6 -1.5 1.2 -0.1 -0.6 0.4
Ulcerative Colitis 0.5 0.7 1.9 -1.4 0.4 -1.2 -0.8 -1.1 -0.3 0.2 -0.3
Blood Eosinophil Count 0.1 0.5 2.1 0.6 0.7 0.3 -0.6 -0.5 0.1 1.5 -0.5
Blood Platelet Count 0.0 0.3 0.7 -0.5 0.8 0.7 -0.5 0.7 0.3 0.4 -0.4
Blood Red Count 0.3 2.4 7.4 -2.3 0.7 2.7 -1.1 0.8 1.1 -0.1 1.8
Blood White Count 0.2 1.6 3.6 -1.1 1.1 0.1 -1.9 -0.4 1.5 -1.4 1.5
Heel T-Score 0.4 2.9 7.9 1.0 0.0 1.8 2.5 2.8 -0.4 2.1 0.3
BMI 0.2 1.2 7.5 -0.3 -0.2 -0.8 0.2 -2.7 -0.7 -0.7 -0.2
Height 0.1 2.2 5.3 2.0 -1.7 -0.7 -2.3 -2.0 0.9 -0.1 0.8
Waist Hip Ratio (WHR) 0.5 2.2 6.9 1.6 -0.4 -0.2 -1.7 1.1 2.6 0.9 1.9
Systolic Blood Pressure 0.2 1.2 2.3 0.6 -1.4 -0.2 -0.4 1.5 1.2 -1.4 1.1
Smoking Status 1.0 2.3 7.0 -1.3 0.9 0.3 -1.1 -1.4 2.6 -0.4 2.4
Allergy or Eczema 0.8 2.0 5.4 1.2 -1.6 -2.3 -0.4 -1.9 -0.4 1.2 -1.2
Cardiovascular Disease 0.9 3.0 11.1 1.3 3.3 2.4 0.8 0.4 0.9 1.9 0.2
Hypothyroidism (self reported) 0.4 0.9 2.6 -1.0 -0.1 1.6 0.3 1.2 0.1 -1.2 0.5
Respiratory disease 0.5 1.1 3.2 0.6 0.7 -0.8 -1.1 -0.1 1.7 0.4 1.8
Type 2 Diabetes (T2D) (2018) 0.4 0.8 3.3 0.1 1.0 1.8 1.0 0.8 -0.1 -0.0 -0.4
Lung FEV1/FVC ratio 0.3 1.3 3.2 -1.3 0.0 0.8 -0.9 -1.1 -1.1 -1.8 -1.2
Lung FVC 0.2 1.2 2.6 1.2 1.6 0.6 1.2 1.0 0.5 1.3 1.1
Neuroticism 0.3 0.6 2.2 -0.7 -1.5 -0.1 -0.0 0.8 1.1 0.0 0.8
Chronotype (morning person) 0.4 0.9 1.7 -0.8 -1.2 -1.3 -0.9 -0.6 -0.8 -1.2 -0.5
Hair Pigment 0.0 0.7 2.8 0.6 0.1 0.7 1.7 -0.4 -0.5 -1.2 0.6
Tanning 0.1 1.3 3.6 -1.3 -1.6 -0.1 -0.5 1.9 -0.3 -1.6 0.0
Hand grip strength (left) 0.4 1.0 5.5 2.3 0.3 0.5 -1.3 -0.5 -0.1 0.0 -0.5
Number of treatments/medications taken 0.5 1.0 4.6 0.5 1.4 0.7 0.4 -2.1 0.3 0.3 -0.2
Average weekly spirits intake 0.5 0.6 1.3 -0.9 0.7 1.1 -0.2 -0.5 -1.1 -0.6 -0.5
Sensitivity / hurt feelings 0.9 1.5 4.7 -1.0 -2.1 -2.2 -0.5 -0.4 -0.6 -1.0 -0.7
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.8 0.5 -0.0 0.6 0.9 0.6 0.8 -0.0 0.6
Hearing difficulty/problems: Yes 0.4 0.6 2.3 0.1 1.5 -1.0 0.7 -0.7 -0.3 0.2 -0.4
Relative age of first facial hair 0.4 0.8 2.6 0.9 1.3 -0.0 -1.6 0.5 0.6 0.3 0.6
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.3 -1.1 -0.2 0.2 1.2 -1.1 -1.1 -0.2 -0.2
Ever used hormone-replacement therapy (HRT) 1.5 1.9 10.6 -0.9 -0.0 -3.3 -0.7 -1.7 -0.3 -0.3 -0.4
Ever had hysterectomy (womb removed) 0.5 0.5 1.8 1.3 -0.3 0.6 0.2 -0.0 -0.6 0.7 -1.0
Systolic blood pressure, automated reading 0.3 0.9 1.7 -0.4 -1.2 -0.6 -0.6 1.0 1.1 -1.3 0.9
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 4.3 0.1 -0.6 0.5 -2.1 -0.3 0.6 -1.4 0.8
Angina 0.3 0.4 0.8 0.5 -0.4 -0.1 -0.3 -0.5 0.8 0.9 0.8
Medication for hormone replacement therapy 1.5 1.7 5.7 -0.7 -0.2 -2.4 -1.6 -1.6 -1.0 -0.3 -1.1
Vitamin and mineral supplements 0.9 1.2 3.3 -0.2 1.2 -0.6 -1.8 1.2 0.3 -1.7 0.1
Supplements: Zinc 1.2 1.4 3.3 -1.4 -0.0 1.2 1.1 0.6 -1.8 0.2 -1.6
Medication: Co-codamol 1.2 1.4 4.5 -1.2 2.1 -0.8 -1.3 -1.5 -0.3 -0.9 -0.1
Medication: Metformin 0.8 1.1 3.2 -1.2 1.1 0.7 -1.0 -0.6 0.4 -1.8 1.0
Diabetes (father) 1.1 1.3 5.1 -0.3 1.1 2.3 1.4 0.6 1.0 0.5 0.8
Diabetes (mother) 0.7 0.8 1.8 0.7 0.8 0.3 1.0 -1.4 1.2 0.5 1.1
Severe depression (siblings) 1.0 1.2 3.2 -1.2 -0.2 -0.9 -1.8 -1.4 -0.5 -1.1 -0.4
Pack years adult smoking proportion 0.1 0.1 0.4 0.1 -0.1 0.0 0.6 0.4 0.4 0.5 -0.3
Impedance of leg (right) 0.3 1.4 3.6 0.6 0.2 0.2 -1.6 1.3 1.9 -0.8 1.6
Leg fat-free mass (left) 0.3 1.7 4.9 0.6 -1.4 -0.5 -0.7 -2.2 -1.7 0.1 -1.6
Trunk fat percentage 0.3 1.0 2.3 0.9 -0.0 -0.6 0.2 -1.5 -1.5 -0.9 -1.3
Hand grip strength (right) 0.3 0.7 4.0 2.0 0.1 0.1 -1.2 0.2 0.3 0.1 0.0
Townsend deprivation index at recruitment 0.4 0.6 1.3 -0.6 0.3 0.9 -0.3 0.6 1.1 0.8 1.1
Current tobacco smoking 1.1 1.9 4.4 -1.1 1.2 1.0 -1.1 -1.4 2.1 -1.2 1.6
Average weekly fortified wine intake 0.8 0.9 2.7 0.3 1.2 0.7 0.8 1.0 -1.6 -0.5 -1.0
Maternal smoking around birth 0.5 0.8 3.3 -1.0 0.4 0.2 -1.2 -0.2 -0.2 -1.8 -0.1
Fed-up feelings 0.3 0.5 1.6 0.7 0.1 0.7 -0.2 -0.5 1.3 0.8 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.3 1.2 -0.7 0.1 0.8 1.1 -0.4 0.3 -0.3 -0.1
Relative age voice broke 0.5 0.7 2.4 0.4 -0.1 -0.6 -1.0 -0.7 1.2 -0.1 1.5
Taking other prescription medications 0.5 0.8 2.4 -0.1 1.6 0.8 -0.5 -1.4 1.1 -0.1 0.2
Age when periods started (menarche) 0.4 1.1 2.8 0.5 0.9 1.7 1.3 0.6 0.8 1.2 0.9
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 3.6 0.4 -1.3 -0.9 -1.7 -1.9 -0.3 -0.8 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 3.7 -0.2 0.1 1.2 1.8 1.9 -1.0 0.6 -0.5
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 2.4 -0.1 0.3 0.1 1.5 -1.5 -0.1 0.7 -0.4
Qualifications: CSEs or equivalent 0.3 0.4 1.2 -0.9 -1.1 -0.6 0.4 -0.4 -0.0 0.9 -0.2
Serious illness, injury or assault to yourself 1.1 1.3 3.5 -1.9 1.3 1.9 -0.4 -0.9 0.3 -0.1 0.8
High blood pressure 1.0 2.7 8.0 0.3 2.0 2.3 2.8 0.5 0.0 1.9 -0.6
Hayfever, allergic rhinitis or eczema 1.3 2.8 6.1 0.9 -2.2 -2.4 -1.4 -2.5 -0.7 0.5 -1.5
Multivitamins +/- minerals 1.6 2.1 5.8 0.7 -0.1 1.3 2.4 -0.7 -1.7 1.9 -1.2
Stomach or abdominal pain in last month 0.6 0.7 2.6 -0.8 -0.0 0.3 -1.6 -1.1 1.0 0.2 0.5
Supplements: Glucosamine 0.3 0.4 1.6 -1.3 -0.3 0.0 0.2 -0.3 0.6 -0.8 0.9
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.3 -0.1 0.7 -1.1 0.8 -1.5 0.5 0.4 0.6
Medication: Atenolol 0.8 1.0 5.4 0.9 0.6 2.3 0.5 -0.0 -0.6 0.5 -0.6
Medication: Levothyroxine sodium 0.2 0.3 1.0 -0.3 -0.2 0.6 0.1 1.0 -0.5 -0.8 -0.2
Sitting height 0.3 2.3 6.9 1.9 -2.6 -1.3 -2.2 -1.0 0.3 0.5 -0.3
Chronic bronchitis/emphysema (father) 0.8 1.0 4.3 -2.1 0.7 0.4 -0.6 0.1 0.9 -0.6 1.1
High blood pressure (mother) 0.4 0.6 1.9 0.6 1.4 1.1 0.1 -0.4 -0.6 -0.4 -0.8
Body mass index (BMI) 0.4 1.7 6.0 -0.8 -0.6 -1.0 0.1 -2.4 -1.7 -0.8 -1.3
Impedance of leg (left) 0.3 1.5 4.1 0.5 -0.1 0.5 -1.4 1.4 2.0 -0.9 1.5
Leg predicted mass (left) 0.3 1.7 5.1 0.6 -1.4 -0.5 -0.7 -2.3 -1.6 0.0 -1.6
Trunk fat mass 0.3 1.5 4.4 0.9 -0.6 -0.8 -0.4 -2.1 -1.6 -0.8 -1.5
Waist circumference 0.2 0.8 2.1 0.2 -0.5 -0.6 -0.7 -1.5 -1.3 -0.7 -1.1
Number of incorrect matches in round 1.0 1.7 5.5 -2.0 -0.5 -1.4 -1.3 -0.8 -0.4 -2.3 0.0
Past tobacco smoking 0.5 1.0 4.2 0.8 -0.6 -0.0 0.2 0.5 -1.6 -0.2 -2.1
Alcohol usually taken with meals 1.6 2.7 5.7 -0.5 -0.3 -1.2 -2.0 -2.0 -2.4 -1.3 -2.0
Nervous feelings 0.7 1.2 3.7 -1.0 -1.0 1.2 -0.9 1.9 0.4 -1.2 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 3.9 -1.0 -0.5 1.0 -0.8 -0.2 -0.2 -2.0 0.3
Hearing difficulty/problems with background noise 0.2 0.3 0.8 0.3 -0.4 -0.7 0.4 0.7 0.9 0.1 0.7
Hair/balding pattern: Pattern 2 0.4 0.5 2.5 -0.4 0.8 -0.9 0.4 1.6 0.1 -0.0 0.0
Had menopause 0.4 0.5 2.3 -0.9 0.2 0.5 -0.3 1.5 0.1 -0.7 0.1
Had other major operations 0.8 1.0 3.2 -0.3 -1.8 -1.6 -0.1 -0.4 -0.1 1.1 -0.7
Forced vital capacity (FVC) 0.1 0.3 0.7 0.8 -0.4 0.8 -0.1 0.3 0.3 0.9 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 5.5 -0.7 0.4 0.6 2.3 2.0 -0.4 1.4 -0.0
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 2.5 1.1 1.6 0.6 1.1 -1.5 -0.6 1.2 -1.3
Qualifications: None of the above 0.5 1.1 3.4 0.2 -0.2 0.3 -0.7 1.1 1.7 -0.7 1.9
Financial difficulties in last 2 years 1.4 1.9 4.0 -2.0 -0.8 0.7 -1.4 -1.5 -1.0 -1.8 -1.2
Mouth/teeth dental problems 0.3 0.4 1.5 0.6 0.3 -0.4 -1.0 -0.1 -0.1 -1.2 0.1
Heart attack 0.4 0.5 1.3 0.0 -0.0 1.2 0.7 -0.9 0.4 1.1 -0.2
Allergy 1.3 3.1 9.1 -0.3 2.2 3.0 2.5 1.7 0.3 0.2 1.2
Pain all over the body in last month 0.5 0.5 1.3 -0.8 -0.3 1.1 0.3 0.5 -0.9 -0.8 -0.4
Diabetes (self-reported) 0.3 0.4 2.2 -0.1 0.5 1.5 -0.2 0.1 -0.1 -0.8 0.1
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 1.6 -0.4 0.6 -1.0 -1.3 -1.1 -1.3 -0.3 -1.0
Medication: Ramipril 0.4 0.5 1.0 -1.0 0.5 -0.3 0.7 0.9 0.6 -0.7 0.6
Medication: Simvastatin 1.2 1.8 5.0 -0.2 1.6 1.9 2.2 1.2 0.6 1.0 0.6
Fluid intelligence score 0.8 1.7 3.1 1.6 0.2 1.4 1.5 0.7 -1.8 0.7 -1.7
Illnesses of siblings 0.5 0.8 2.0 0.6 -0.5 0.9 -0.3 -1.4 0.7 0.8 1.2
Neuroticism score 0.1 0.3 0.6 -0.4 -0.7 0.2 -0.7 0.0 0.6 -0.8 0.4
Weight 0.4 2.1 7.6 0.1 -1.3 -0.9 -1.2 -2.8 -1.7 -0.8 -1.4
Impedance of arm (right) 0.2 1.1 2.2 1.2 1.2 1.1 -0.4 1.5 1.0 -0.5 1.2
Arm fat percentage (right) 0.3 1.0 2.6 0.0 0.3 -0.3 -0.0 -1.6 -1.6 -1.2 -1.1
Trunk fat-free mass 0.4 2.1 5.0 -0.0 -2.2 -0.7 -2.0 -2.2 -0.9 -0.3 -1.2
Hip circumference 0.4 1.6 4.4 -0.2 -0.6 -0.9 -0.6 -1.8 -2.1 -0.9 -1.7
Time employed in main current job 1.0 1.2 7.0 -1.4 -2.6 0.1 0.3 0.3 -0.3 -0.2 0.3
Alcohol intake versus 10 years previously 0.4 0.6 1.6 -1.1 1.3 0.8 0.3 0.1 1.0 -0.2 0.5
Father’s age at death 0.7 0.9 3.5 0.2 -0.0 -1.9 0.9 -1.5 -0.2 0.7 -0.2
Worrier / anxious feelings 0.9 1.7 7.0 -0.9 -0.5 -1.4 -0.7 0.2 2.6 0.6 1.7
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.3 0.6 0.1 -0.1 1.5 -0.7 -0.1 1.2 -0.9
Falls in the last year 0.3 0.4 1.1 -0.9 0.8 -0.1 -0.2 -1.1 -0.5 -0.7 -0.4
Hair/balding pattern: Pattern 3 0.9 1.4 4.0 -1.5 -0.5 1.2 -0.5 -1.4 -2.0 -0.9 -0.6
Number of live births 0.4 0.5 2.3 0.4 1.5 0.5 -0.6 -0.0 0.6 0.6 0.8
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.9 0.5 -0.3 0.9 -0.3 -0.0 -0.3 0.4 -0.2
Pulse rate 2.9 4.9 24.6 -2.3 -0.6 0.5 -5.0 1.4 1.7 -1.2 1.6
Happiness 0.8 0.9 2.9 0.7 0.1 1.7 0.4 -0.3 1.3 1.1 1.0
Noisy workplace 0.5 0.6 1.9 -1.4 -1.1 0.2 0.4 -0.6 0.5 -0.9 0.6
Qualifications: A levels/AS levels or equivalent 0.7 1.7 7.0 -0.5 0.9 2.6 -0.4 -0.9 -0.7 -1.8 -0.6
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 5.1 0.1 2.3 0.9 0.6 -0.4 -0.7 1.4 -0.8
Mouth/teeth dental problems: Dentures 0.8 1.3 4.4 -2.1 -0.2 0.1 0.1 0.6 1.9 -0.2 1.5
Asthma 0.7 1.3 4.5 0.1 0.6 -2.1 -2.1 -0.0 0.5 -0.7 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 2.0 1.1 1.4 -0.8 -0.0 -1.2 -0.7 1.4 -1.2
Medication: Cholesterol lowering 0.5 0.8 2.6 0.7 0.0 1.6 1.1 0.7 0.6 0.9 0.3
Depression (self-reported) 0.4 0.4 1.8 -0.0 0.4 0.0 0.3 -0.6 1.0 1.4 -0.4
Medication: Lansoprazole 0.6 0.7 2.9 -0.3 1.3 0.7 -0.1 -1.7 0.2 -0.3 -0.2
Prospective memory result 2.6 3.1 9.1 -0.4 -0.6 -1.3 -1.1 0.1 3.0 -1.9 3.0
Lung cancer (father) 0.1 0.2 0.5 0.7 0.4 0.4 -0.0 -0.5 0.2 0.1 0.4
Illnesses of mother 1.2 1.5 4.5 -1.8 -0.1 -2.1 -1.8 0.0 -0.2 -1.2 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.5 0.3 -0.3 0.6 -0.7 0.0 0.1 -0.2 0.6
Pulse wave Arterial Stiffness index 1.2 1.3 2.7 -1.6 1.2 0.8 -0.8 0.7 1.0 -1.4 1.4
Impedance of arm (left) 0.2 0.8 2.0 1.4 0.7 0.7 -0.3 1.4 0.7 -0.6 0.7
Arm fat mass (right) 0.3 1.2 4.6 -0.0 -0.4 -0.7 -0.4 -2.1 -1.4 -1.0 -1.0
Trunk predicted mass 0.4 2.1 5.2 0.0 -2.3 -0.7 -2.0 -2.3 -0.9 -0.4 -1.2
Standing height 0.2 1.6 4.8 2.0 -1.9 -0.2 -2.2 -0.7 0.1 0.2 -0.3
Length of working week for main job 0.6 0.6 2.1 -1.0 0.1 0.9 0.2 -1.4 -0.8 -0.0 -0.6
Exposure to tobacco smoke at home 1.7 1.9 4.3 0.1 -1.4 -2.1 -1.5 -1.8 1.4 0.5 1.1
Breastfed as a baby 0.7 0.9 3.9 -2.0 -0.1 -0.7 1.1 -0.8 -0.6 -0.1 -0.8
Tense / ‘highly strung’ 0.4 0.6 2.1 0.2 -0.7 0.4 1.4 1.5 -0.2 -0.5 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.3 3.9 1.0 0.6 -0.8 -1.8 -2.0 1.0 0.1 0.6
Hair/balding pattern: Pattern 4 0.2 0.4 1.9 0.1 -1.4 0.5 0.5 0.7 0.2 -0.0 -0.6
Birth weight of first child 0.7 1.3 3.4 0.3 -0.3 1.3 1.2 0.1 -1.8 0.6 -1.7
Peak expiratory flow (PEF) 0.5 1.1 3.4 1.4 -0.5 -0.5 0.1 0.3 -1.9 0.1 -1.6
Pulse wave reflection index 0.4 0.5 2.6 -0.3 0.7 -0.5 1.6 -0.6 -0.2 -0.0 -0.0
Ever highly irritable/argumentative for 2 days 2.4 2.8 10.3 1.6 1.7 -0.5 2.1 -1.2 -0.0 3.2 -0.9
Loud music exposure frequency 2.0 2.2 6.2 -2.5 1.1 -0.5 -0.9 -1.2 -1.5 -1.4 -1.9
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.9 0.6 0.5 1.5 -0.0 0.1 -1.4 -0.1 -1.7
Mouth/teeth dental problems: Bleeding gums 0.3 0.5 1.5 0.6 -0.5 -0.2 0.1 -0.5 -0.7 0.9 -1.2
Blood clot in the leg (DVT) 0.6 0.8 2.5 -0.5 -1.5 0.1 -0.9 -0.2 -0.6 -1.6 0.0
Medication: Paracetamol 0.3 0.5 1.9 -0.1 -1.1 0.2 0.4 -1.4 -0.5 -0.1 -0.4
Headache pain in last month 0.2 0.4 1.2 0.5 0.8 0.0 0.3 -0.4 -0.7 -0.1 -1.1
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 3.4 -1.7 -1.3 -1.8 -1.6 -0.3 -0.8 -1.8 -0.6
Glaucoma (self-reported) 1.7 2.0 6.7 -0.3 -0.0 -1.5 -2.6 -2.4 0.3 -0.8 0.6
Gout (self-reported) 1.5 2.1 10.1 -1.6 0.8 3.2 1.5 -0.7 -0.7 -0.7 0.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.3 -0.7 0.3 1.3 -0.2 0.3 -0.0 -1.5 0.4
Medication: Amlodipine 0.8 1.2 3.5 1.9 0.9 0.9 -0.1 -1.1 1.1 1.2 0.6
Medication: Ventolin 100micrograms inhaler 2.0 2.5 6.9 1.4 2.3 -0.9 -0.6 -0.4 -2.2 0.0 -2.6
Birth weight 1.2 2.5 6.6 -0.7 -0.3 -2.0 -0.8 -2.6 -1.7 -1.3 -2.0
Chronic bronchitis/emphysema (mother) 1.3 1.5 5.2 0.9 1.9 0.6 2.3 0.3 -0.6 1.1 0.3
High blood pressure (siblings) 1.5 2.2 6.2 -1.4 -0.9 -2.0 -1.5 0.8 -1.0 -2.5 -0.9
Forced vital capacity (FVC), Best measure 0.2 0.8 1.8 1.2 -0.2 0.7 -0.8 0.0 1.0 0.8 1.3
Body fat percentage 0.3 1.1 2.7 0.5 -0.3 -0.8 0.1 -1.6 -1.5 -1.1 -1.2
Leg fat percentage (right) 0.4 1.4 3.8 -0.1 -0.8 -1.4 -0.8 -2.0 -1.2 -1.3 -1.0
Arm fat-free mass (right) 0.5 2.4 7.1 -0.0 -2.1 -1.0 -1.3 -2.7 -1.3 -0.4 -1.6
Exposure to tobacco smoke outside home 1.6 2.1 5.1 -1.3 -0.4 -1.6 -2.3 -2.2 0.3 -1.4 0.7
Comparative body size at age 10 0.4 1.2 4.0 0.0 -0.4 1.2 -0.6 -1.1 -2.0 -1.1 -0.9
Number of full brothers 0.6 0.8 2.0 0.0 1.2 0.3 -1.3 -1.4 -0.3 -0.8 -0.4
Worry too long after embarrassment 0.3 0.5 1.4 1.0 -0.9 -1.2 0.4 -0.0 0.3 0.6 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 7.0 0.3 2.6 1.2 -1.8 -1.8 0.3 -1.2 0.0
Wheeze or whistling in the chest in last year 0.3 0.6 2.1 -1.1 0.0 1.0 -0.5 -1.4 -0.2 -0.5 0.0
Number of children fathered 0.4 0.5 1.0 0.9 -0.8 0.3 0.8 0.5 0.5 -0.4 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 3.2 -0.1 -0.8 -0.8 -0.8 1.0 -0.5 -1.8 -0.2
Age at first live birth 2.0 3.6 8.8 0.7 1.9 2.2 3.0 0.8 -1.4 2.2 -1.9
Pulse wave peak to peak time 1.3 1.5 3.1 1.8 -1.2 -0.9 0.8 -1.0 -1.1 1.3 -1.5
Health satisfaction 0.6 0.8 2.5 -0.0 0.6 -0.5 0.1 -1.6 -1.2 0.2 -1.4
Shortness of breath walking on level ground 1.1 1.3 4.5 -0.5 1.3 0.2 -1.0 -1.5 0.5 -2.1 0.6
Qualifications: College or University degree 0.6 2.0 4.8 1.0 0.2 1.9 1.1 0.3 -2.2 -1.3 -2.0
Eye problems/disorders: None of the above 2.5 2.9 9.6 0.0 0.6 2.8 3.1 -0.8 -0.8 1.7 -1.0
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.4 -0.1 1.2 0.7 -0.7 0.3 0.2 -0.9 0.8
Emphysema/chronic bronchitis 0.3 0.4 1.4 1.2 -0.4 -0.4 -0.3 1.0 -0.1 0.2 -0.2
Medication for pain relief, constipation, heartburn 0.3 0.5 2.7 0.0 0.2 0.8 -0.1 1.6 0.3 0.9 0.1
Neck or shoulder pain in last month 0.4 0.5 1.9 0.7 0.6 0.8 -1.4 -0.8 0.4 -0.1 0.1
Medication: Blood pressure 0.8 1.3 3.1 0.6 1.1 1.4 1.8 1.2 0.9 0.7 1.2
Angina (self-reported) 0.3 0.4 1.0 0.5 -0.8 0.0 0.1 -0.4 0.8 1.0 0.9
Migraine (self-reported) 1.4 1.8 4.8 1.0 1.9 2.2 1.3 0.1 -1.1 -0.5 -1.1
Medication: Ibuprofen 1.3 1.5 3.1 1.7 1.3 -0.8 -0.1 -1.0 -0.8 1.7 -1.5
Medication: Allopurinol 2.5 3.4 15.0 -0.5 0.5 3.9 2.8 1.4 -1.1 -0.1 -0.3
Medication: Omeprazole 0.3 0.4 1.5 0.1 -0.2 -1.2 0.1 -0.5 0.6 -1.0 0.1
Medication: Seretide 50 evohaler 0.6 0.7 1.3 0.5 -1.1 -1.1 -0.7 1.0 -0.7 -0.3 -0.9
Mean time to correctly identify matches 0.6 1.2 2.7 0.7 -1.6 -1.6 0.5 1.2 1.0 -0.1 1.0
Heart disease (mother) 0.9 1.2 2.8 0.6 0.3 1.7 1.0 0.1 1.6 0.7 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 3.6 -0.5 -0.3 -1.9 1.3 1.0 0.1 -0.2 -0.6
Whole body fat mass 0.3 1.3 4.3 0.6 -0.9 -0.6 -0.2 -2.1 -1.5 -0.7 -1.4
Leg fat mass (right) 0.4 1.5 5.3 0.4 -1.2 -0.8 -0.4 -2.3 -1.4 -0.7 -1.3
Arm predicted mass (right) 0.5 2.5 8.2 -0.1 -2.2 -1.2 -1.3 -2.9 -1.2 -0.1 -1.7
Pulse rate, automated reading 2.5 8.1 52.5 -0.5 1.0 1.1 -7.2 1.8 1.4 -1.6 1.4
Alcohol intake frequency. 0.3 0.6 2.6 -0.1 0.2 1.2 -1.6 -0.4 0.1 -0.4 0.7
Comparative height size at age 10 0.4 2.1 9.5 -0.4 -0.7 -0.3 -3.1 -2.1 -0.6 -1.4 -0.6
Number of full sisters 0.6 0.8 2.2 0.3 1.1 -0.7 -0.1 1.1 0.8 1.5 0.5
Suffer from ‘nerves’ 0.8 1.3 3.2 0.1 -0.5 1.8 -0.2 1.3 1.4 -0.7 1.6
Overall health rating 0.2 0.4 1.1 -0.0 0.7 0.3 0.8 -0.8 0.7 1.0 0.0
Chest pain or discomfort 1.1 1.5 9.0 0.8 -0.2 3.0 1.2 -0.6 -0.1 0.8 -0.0
Had major operations 0.5 0.6 3.0 0.1 -0.6 -1.1 0.4 -1.7 -0.1 0.3 -0.4
Age at last live birth 2.1 3.0 6.1 1.3 1.7 1.3 1.6 0.6 -2.1 2.2 -2.5
Family relationship satisfaction 0.3 0.4 1.6 0.3 -0.0 0.4 0.3 -1.3 -0.3 1.0 -0.5
Leg pain on walking 0.8 1.0 2.9 -1.3 -0.1 -1.0 -1.7 -0.8 -0.1 -1.3 0.3
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.6 4.1 -1.1 1.0 -1.1 -2.0 -0.5 1.3 -0.4 1.8
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.4 -0.9 -0.2 -1.1 -0.4 -1.0 -1.2 -0.6 -1.1
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 3.8 1.1 -1.4 -2.0 -0.7 0.3 0.8 -0.7 0.9
Medication: Aspirin 0.8 1.0 3.9 -0.1 1.4 2.0 0.4 0.2 0.5 -0.9 1.1
Supplements: Vitamin C 0.6 0.7 2.5 -0.2 -1.6 -0.3 0.7 0.1 0.9 1.3 0.4
Knee pain experienced in last month 1.0 1.5 4.7 -0.2 1.9 2.2 1.0 -0.7 -0.8 0.6 -1.2
Hypertension (Self-reported) 0.9 2.6 6.6 0.5 2.3 2.2 2.6 0.6 0.4 1.8 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 1.9 -0.8 -1.3 0.1 -1.1 -1.4 -0.6 -1.3 -0.6
Illnesses of father: Heart disease 0.7 0.9 2.9 0.8 1.6 1.7 0.2 0.5 -0.7 0.6 -0.7
Illnesses of siblings: Diabetes 0.9 1.2 3.7 0.3 0.0 -0.6 1.4 1.9 -0.1 1.8 -0.1
Smoking status: Previous 0.5 0.8 3.8 -0.3 -0.2 0.2 0.0 0.3 1.5 0.4 1.9
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 3.8 1.9 0.3 1.0 -1.2 -1.1 -0.9 0.5 -1.0
Whole body fat-free mass 0.4 2.3 6.7 0.1 -2.0 -0.8 -1.6 -2.6 -1.4 -0.3 -1.6
Leg fat-free mass (right) 0.3 1.5 4.4 0.5 -1.3 -0.2 -0.6 -2.1 -1.7 0.1 -1.7
Arm fat percentage (left) 0.4 1.4 3.6 0.1 -0.2 -0.8 -0.0 -1.9 -1.9 -1.3 -1.4
Average weekly red wine intake 0.3 0.5 1.6 0.5 -0.6 -0.6 -1.3 0.1 -0.5 -1.0 0.2
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.6 0.8 1.2 1.6 0.4 0.5 -0.0 1.2 -0.4
Mood swings 0.6 1.1 4.7 -1.6 -0.0 0.9 -0.3 -2.2 0.0 0.6 -0.7
Loneliness, isolation 0.6 0.8 1.5 -0.1 -1.1 -0.8 -1.0 -0.5 -0.8 -1.2 -1.0
Long-standing illness, disability or infirmity 0.4 0.6 2.0 -1.2 0.4 1.4 0.5 -1.0 0.0 -0.0 0.1
Ever had bowel cancer screening 2.2 2.5 9.1 1.3 -1.6 -3.0 2.2 0.5 -0.1 1.3 0.1
Diabetes diagnosed by doctor 0.4 0.7 2.4 0.1 1.2 1.5 0.7 0.0 -0.7 -0.7 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 3.1 -1.8 0.2 -0.9 -0.6 -0.3 -0.2 -1.8 -0.1
Friendships satisfaction 0.2 0.3 1.0 1.0 -0.3 -0.3 -0.6 -0.5 -0.4 0.5 -0.5
Qualifications: nursing, teaching 0.3 0.5 2.3 -0.3 -0.3 0.1 -0.6 -1.5 -0.8 -0.4 -0.4
Commuting to job workplace: Walk 0.8 0.8 3.6 1.9 0.5 -1.3 0.1 0.9 0.2 0.2 0.3
Eye problems/disorders: Cataract 1.1 1.3 3.5 -0.8 0.2 -1.7 -1.2 1.9 -0.6 -0.9 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.8 0.6 -0.2 0.8 1.2 0.9 -0.6 1.7 -0.6
Medication for cholesterol 0.3 0.5 3.1 0.1 -1.8 -0.9 -0.3 0.1 -0.0 -0.3 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.5 -0.2 -0.9 0.5 -0.6 0.5 0.7 0.4 1.2
Back pain experienced in last month 1.4 2.0 6.5 -0.2 1.6 1.6 1.2 0.3 2.5 0.3 1.6
Mineral and other dietary supplements 0.4 0.6 3.0 0.6 0.9 -0.4 -1.7 0.2 0.3 -0.6 0.1
Breast cancer (self-reported) 0.4 0.5 1.7 -0.0 -0.7 -1.3 0.6 -0.2 -0.5 -0.1 -1.1
Asthma (self-reported) 0.6 1.3 4.7 0.3 0.4 -2.2 -2.0 -0.0 0.5 -0.7 0.7
Osteoporosis (self-reported) 0.5 0.6 1.4 1.1 0.1 -1.2 0.7 -0.7 0.0 1.0 -0.7
Osteoarthritis (self-reported) 1.7 2.3 9.5 -3.1 0.2 -0.1 0.2 -2.0 -0.3 -2.0 -0.1
Medication: Aspirin 0.7 0.9 3.2 -0.0 0.9 1.8 0.6 0.5 0.4 -0.9 1.1
Medication: Gliclazide 0.7 0.8 2.4 -0.8 0.2 -0.2 -0.6 0.1 1.6 -1.2 1.2
Illnesses of father: None of the above (group 1) 0.5 0.6 1.6 0.9 -0.4 -0.0 1.0 -0.8 -0.3 1.3 -0.7
Smoking status: Current 1.1 1.7 4.1 -1.4 1.2 0.5 -0.9 -1.3 2.0 -0.9 1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.8 -0.9 0.5 0.5 -0.0 -0.2 -0.2 -0.6 0.2
Whole body water mass 0.4 2.2 6.2 0.0 -1.8 -0.8 -1.4 -2.5 -1.6 -0.3 -1.7
Leg predicted mass (right) 0.3 1.6 4.3 0.4 -1.4 -0.2 -0.6 -2.1 -1.6 0.1 -1.7
Arm fat mass (left) 0.4 1.8 5.3 0.0 -0.8 -1.0 -0.3 -2.3 -2.0 -1.1 -1.6
Number of self-reported non-cancer illnesses 0.5 0.9 3.5 0.3 1.9 0.2 0.7 -1.4 0.0 0.6 -1.0
Average weekly champagne plus white wine intake 0.8 1.1 3.0 -0.8 0.3 0.4 1.2 -1.0 -1.3 0.9 -1.7
Miserableness 0.3 0.6 1.1 -0.5 -0.3 0.9 -1.0 -0.4 0.9 -1.1 0.6
Guilty feelings 0.6 0.9 3.2 -0.8 -0.2 -0.4 -0.9 -1.8 -0.2 -1.5 0.0
Wears glasses or contact lenses 1.2 1.3 4.6 0.7 2.1 -0.3 -1.4 0.6 -1.2 -1.3 -0.4
Ever taken oral contraceptive pill 0.7 0.8 2.5 0.6 1.0 0.3 -1.6 -0.6 -0.7 -0.3 -1.0
Hearing aid user 1.8 2.1 5.7 -0.0 0.7 -2.0 1.0 -0.9 -2.1 0.1 -2.4
Mother’s age at death 0.6 0.7 2.0 -0.7 -1.2 -1.4 -0.1 -0.8 -0.6 -0.4 -0.8
Financial situation satisfaction 0.5 0.6 1.4 -1.0 0.2 0.8 -0.3 -1.2 0.6 -1.0 0.4
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.2 0.8 -0.6 -1.1 0.7 0.9 -0.8 0.8 -0.8
Commuting to job workplace: Public transport 0.7 0.8 1.9 0.2 1.2 1.4 0.3 1.0 0.9 -0.1 1.0
Eye problems/disorders: Glaucoma 2.2 2.6 8.8 -0.6 -0.8 -1.7 -3.0 -1.9 0.8 -1.3 1.3
Medication: Blood pressure 0.5 0.9 2.1 -0.2 1.0 0.8 0.8 0.1 1.5 1.4 0.9
Pain type(s) experienced in last month: Hip pain 0.4 0.6 1.3 -0.4 -0.2 1.1 1.2 -0.6 -0.9 0.4 -0.6
Supplements: Fish oil (including cod liver oil) 1.0 1.3 7.4 -0.4 -1.1 0.5 2.7 0.3 -0.0 1.1 0.1
High cholesterol (Self-reported) 0.5 0.9 5.7 -0.2 2.4 0.8 -0.1 -0.7 -0.6 -0.1 0.0
Medication: Bendroflumethiazide 0.5 0.7 1.9 0.2 0.0 -0.8 0.6 -1.4 1.2 1.0 0.6
Medication: Paracetamol 0.1 0.2 0.6 0.1 -0.8 -0.6 0.6 -0.5 -0.3 -0.0 -0.3
Medication: Lisinopril 0.8 1.0 2.5 0.1 1.0 1.1 0.5 0.3 1.6 0.8 1.4
Medication: Atorvastatin 0.2 0.3 0.6 0.6 0.5 0.8 0.1 0.1 -0.5 0.0 -0.7
Illnesses of father: High blood pressure 0.9 1.1 3.8 0.5 0.7 0.4 -1.9 0.7 0.2 -1.8 0.8
Alcohol drinker status: Never 0.5 0.6 2.2 0.1 0.2 0.7 0.5 1.5 -0.5 1.1 0.2
Ever smoked 0.5 0.9 3.1 -0.8 1.8 0.4 -0.6 -0.8 0.8 -0.1 1.2
Basal metabolic rate 0.4 2.0 6.3 0.3 -1.7 -0.7 -1.4 -2.5 -1.4 -0.3 -1.5
Leg fat percentage (left) 0.4 1.3 3.8 -0.3 -1.1 -1.4 -0.7 -1.9 -0.8 -1.3 -0.8
Arm fat-free mass (left) 0.3 1.6 6.0 0.0 -1.7 -0.8 -1.1 -2.4 -1.0 -0.2 -1.2
Number of operations (self-reported) 0.5 0.8 5.4 0.4 -0.1 -0.7 0.1 -2.3 -0.3 0.4 -0.2
Average weekly beer plus cider intake 1.2 1.7 4.9 -0.2 -0.8 -1.1 1.1 1.2 2.2 1.5 1.5
Irritability 0.7 1.2 3.1 -1.2 -1.5 -0.3 0.3 -0.3 -1.3 -1.8 -1.0
Risk taking 2.2 3.3 7.1 -2.1 -0.9 -1.8 -0.2 -2.7 -2.3 -1.1 -2.1
Ever had prostate specific antigen (PSA) test 0.4 0.5 2.2 0.6 0.1 -1.5 0.5 -0.3 -0.8 0.3 -0.4
Fractured/broken bones in last 5 years 1.6 2.0 5.7 -1.8 -0.1 -0.9 -1.6 -2.4 0.9 -0.7 1.6
Age started oral contraceptive pill 1.4 1.8 6.5 -0.7 -0.7 -0.7 -1.0 0.8 2.5 0.2 2.2
Diastolic blood pressure, automated reading 0.5 1.6 5.6 -1.5 0.0 -0.7 -2.4 0.3 0.1 -2.2 0.0
Ever depressed for a whole week 0.4 0.5 2.5 -0.3 1.0 -0.5 -0.1 -1.6 0.2 0.5 0.0
Unable to work because of sickness or disability 0.5 0.7 1.7 -1.0 0.3 1.3 -0.7 -0.7 0.3 -1.2 0.4
Commuting to job workplace: Cycle 1.1 1.3 3.6 1.9 0.9 -0.2 1.8 0.5 -0.5 1.1 -0.9
Myopia 1.5 2.2 8.5 0.4 2.9 -0.4 0.8 -2.4 -0.0 1.5 -0.5
Vascular/heart problems diagnosed by doctor 1.0 2.6 7.0 -0.3 -1.8 -2.1 -2.6 -0.5 -0.4 -2.4 0.4
Cholesterol lowering medication 0.4 0.5 2.3 -0.1 1.5 1.0 0.6 0.5 -0.1 -0.2 0.5
Medication: Omeprazole (e.g. Zanprol) 0.5 0.5 3.6 0.2 -0.4 -1.9 0.3 -0.3 0.6 -0.1 0.0
Pain experienced in last month 0.8 1.3 4.1 0.5 -2.0 -1.6 0.6 0.8 -1.3 -0.0 -0.8
Supplements: Calcium 1.1 1.2 2.1 -0.7 1.1 -1.1 -1.4 -0.6 -1.3 -1.3 -0.7
Basal cell carcinoma (self-reported) 0.2 0.2 0.7 -0.1 0.5 -0.1 0.3 -0.8 -0.3 0.5 -0.3
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.2 -0.1 -0.3 0.8 0.7 -1.1 0.2 1.1 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.1 -0.6 -1.3 0.2 -1.1 -0.3 -0.6 -1.8 0.1
Heart disease (siblings) 0.8 1.0 3.1 -0.6 1.8 0.5 -0.8 -1.1 1.0 0.4 1.0
Alcohol drinker status: Previous 0.2 0.2 0.9 -0.0 -1.0 0.5 0.1 0.5 -0.2 0.4 -0.1
Pack years of smoking 0.1 0.1 0.5 -0.2 -0.2 -0.3 0.7 0.2 0.3 0.3 -0.2
Impedance of whole body 0.3 1.4 3.2 1.4 0.7 0.5 -0.9 1.5 1.8 -0.5 1.5
Leg fat mass (left) 0.3 1.3 4.8 0.3 -1.2 -0.7 -0.3 -2.2 -1.2 -0.6 -1.1
Arm predicted mass (left) 0.3 1.8 6.0 -0.0 -1.7 -0.9 -1.3 -2.5 -0.9 -0.2 -1.3