Best TWAS P=3.3e-11 · Best GWAS P=7.67e-11 conditioned to 0.087
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | KLHL42 | 0.18 | 0.16 | lasso | 2 | 0.14 | 4.5e-11 | 6.4 | 6.4 | 1.5e-10 | 1.00 | 0.00 | 1.00 | FALSE |
2 | GTEx | Artery Tibial | RP11-860B13.1 | 0.09 | 0.10 | lasso | 2 | 0.10 | 4.8e-08 | 6.4 | 6.4 | 1.2e-10 | 1.00 | 0.00 | 1.00 | FALSE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC100133893 | 0.04 | 0.08 | blup | 33 | 0.10 | 3.6e-19 | 4.3 | 5.9 | 3.1e-09 | 0.81 | 0.36 | 0.64 | FALSE |
4 | The Cancer Genome Atlas | Colon Adenocarcinoma | LOC100133893 | 0.07 | 0.03 | blup | 33 | 0.07 | 7.1e-05 | 6.3 | 5.9 | 3.0e-09 | 0.85 | 0.02 | 0.95 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC100133893 | 0.07 | 0.10 | blup | 33 | 0.11 | 1.2e-12 | 5.4 | 5.7 | 1.3e-08 | 0.86 | 0.04 | 0.96 | FALSE |
6 | The Cancer Genome Atlas | Lung Adenocarcinoma | LOC100133893 | 0.09 | 0.19 | lasso | 7 | 0.18 | 2.8e-20 | 5.4 | 5.5 | 3.6e-08 | 0.82 | 0.63 | 0.37 | FALSE |
7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LOC100133893 | 0.03 | 0.03 | blup | 33 | 0.03 | 5.4e-04 | 6.5 | 5.4 | 6.4e-08 | 0.92 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LOC100133893 | 0.04 | 0.01 | blup | 33 | 0.03 | 2.1e-03 | 6.4 | 6.0 | 1.6e-09 | 0.86 | 0.01 | 0.81 | FALSE |
9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LOC100133893 | 0.06 | 0.04 | blup | 33 | 0.04 | 1.0e-02 | 4.3 | 6.6 | 3.3e-11 | 0.84 | 0.02 | 0.64 | TRUE |
10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | KLHDC5 | 0.06 | 0.04 | blup | 55 | 0.02 | 6.3e-03 | 6.3 | -5.5 | 3.0e-08 | -0.86 | 0.01 | 0.97 | FALSE |
11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LOC100133893 | 0.08 | 0.09 | lasso | 2 | 0.08 | 2.8e-06 | 6.4 | 6.2 | 6.0e-10 | 0.99 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC100133893 | 0.06 | 0.06 | lasso | 4 | 0.06 | 2.1e-06 | 5.4 | 5.4 | 7.8e-08 | 0.75 | 0.26 | 0.73 | FALSE |