TWAS hub - SSPN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1590	0.0420	5.6e-05	0.065	NA	0.053	NA	0.074	5.5e-06	NA	3.5e-05	NA	1.1e-06
2	GTEx	Artery Aorta	0.1650	0.0630	6.4e-03	-0.001	NA	-0.005	NA	-0.003	3.5e-01	NA	9.0e-01	NA	5.2e-01
3	GTEx	Artery Tibial	0.1726	0.0533	1.1e-03	0.048	NA	0.063	NA	0.060	1.3e-04	NA	1.1e-05	NA	1.6e-05
4	GTEx	Breast Mammary Tissue	0.2690	0.0720	1.5e-04	0.003	NA	0.017	NA	0.018	2.2e-01	NA	4.2e-02	NA	4.1e-02
5	GTEx	Breast Mammary Tissue (Male)	0.2269	0.1527	1.1e-01	-0.013	NA	0.017	NA	-0.013	9.2e-01	NA	1.3e-01	NA	9.7e-01
6	GTEx	Breast Mammary Tissue (Female)	0.1012	0.0904	1.9e-01	-0.005	NA	-0.006	NA	-0.001	4.9e-01	NA	5.4e-01	NA	3.6e-01
7	GTEx	Cells Transformed fibroblasts	0.1430	0.0420	1.5e-04	0.066	NA	0.163	NA	0.136	1.2e-05	NA	3.1e-12	NA	2.1e-10
8	GTEx	Heart Atrial Appendage	0.2680	0.0860	3.4e-03	0.002	NA	0.009	NA	-0.001	2.6e-01	NA	1.2e-01	NA	3.5e-01
9	GTEx	Nerve Tibial	0.1833	0.0592	1.5e-03	0.066	NA	0.056	NA	0.073	1.9e-05	NA	8.4e-05	NA	7.3e-06
10	YFS	Blood	0.0408	0.0151	3.5e-03	0.034	0.009	0.030	0.03	0.036	1.8e-11	3.7e-04	3.0e-10	2.7e-10	5.0e-12
11	TCGA	Liver Hepatocellular Carcinoma	0.1540	0.0600	4.3e-03	0.040	0.066	0.066	NA	0.067	5.8e-03	5.0e-04	5.1e-04	NA	4.6e-04
12	TCGA	Thyroid Carcinoma	0.0800	0.0360	6.8e-04	0.027	0.039	0.040	NA	0.041	1.1e-03	9.5e-05	8.6e-05	NA	7.5e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Pulse rate, automated reading	8.3	26.8	64.2	-5.6	-7.3	-5.7	-8.0	-2.7	-0.9	-5.7	-7.1	-5.8	2.2	-3.0	0.8
Waist Hip Ratio (WHR)	6.4	28.9	63.4	6.5	5.0	1.1	5.5	7.5	1.8	6.0	5.3	5.1	0.6	6.0	8.0
Medication: Metformin	6.4	9.0	16.6	3.5	3.2	3.2	2.6	1.4	0.1	4.1	3.5	3.7	0.2	3.5	3.4
Diabetes diagnosed by doctor	6.4	10.5	17.4	3.7	3.3	3.2	3.1	2.6	-1.2	4.0	3.5	3.5	0.0	4.2	4.0
Diabetes (self-reported)	5.3	8.2	15.1	3.3	3.1	2.6	2.3	1.5	-1.4	3.9	3.3	3.1	-0.5	3.8	3.4
Medication: Gliclazide	5.1	5.7	17.4	2.9	2.5	1.9	2.5	2.1	0.4	2.3	2.2	2.3	1.7	2.1	4.2
Type 2 Diabetes (T2D) (2018)	5.0	9.3	14.2	3.5	3.3	2.8	3.7	2.4	-1.1	3.2	3.4	3.1	0.7	3.7	3.8
Hair/balding pattern: Pattern 4	4.3	10.5	85.2	-0.3	0.2	2.0	2.5	0.8	1.8	-3.0	0.0	-0.2	3.1	-2.7	-9.2
Tinnitus: Yes, now most or all of the time	4.0	4.7	9.4	-3.1	-2.4	-2.0	-2.1	-1.9	0.0	-2.7	-2.6	-2.8	0.1	-1.9	-2.1
Diabetes (mother)	3.9	5.0	19.8	2.4	2.0	1.5	1.5	1.0	1.4	2.5	2.1	1.9	-2.9	4.4	0.4
Mouth/teeth dental problems: Mouth ulcers	3.7	5.9	12.6	2.9	2.1	1.8	3.5	2.6	2.6	2.2	2.2	2.3	-0.3	3.1	-1.8
Hair/balding pattern: Pattern 3	3.6	5.4	43.4	-0.4	-1.1	0.6	-0.1	-1.9	1.4	-2.6	-1.3	-1.0	1.9	-1.0	-6.6
Pulse rate	3.3	5.6	13.4	-2.3	-3.5	-2.7	-3.7	-0.9	-0.2	-2.4	-3.4	-2.3	1.6	-1.2	1.2
Lung cancer (father)	3.2	3.8	8.0	-2.5	-2.6	-2.1	-2.3	-0.9	0.8	-2.0	-2.4	-2.8	1.0	-1.5	0.7
Chronic bronchitis/emphysema (father)	2.5	3.0	5.7	1.8	1.8	0.8	1.9	1.5	2.4	1.9	1.9	1.7	-2.3	0.8	0.8
Impedance of arm (left)	2.5	11.8	21.1	-4.1	-4.4	-4.3	-3.5	-1.3	-0.7	-4.2	-4.6	-4.0	2.9	-3.0	0.1
Medication: Atorvastatin	2.5	3.0	6.8	2.5	1.6	2.0	1.7	0.4	0.1	1.9	1.8	2.6	0.7	2.4	0.7
Migraine (self-reported)	2.4	3.0	10.2	-1.7	-2.3	-0.3	-3.2	-2.4	-1.4	-1.4	-2.1	-1.5	1.3	-0.3	0.3
Unable to work because of sickness or disability	2.4	3.1	8.1	2.2	1.7	2.8	1.0	1.3	-1.2	1.9	1.7	2.2	1.1	2.1	1.0
Mouth/teeth dental problems	2.3	3.6	8.2	-2.2	-1.5	-1.4	-2.2	-2.0	-1.4	-1.4	-1.4	-1.5	0.4	-2.8	2.9
Ever had bowel cancer screening	2.3	2.7	5.0	-2.1	-1.9	-1.4	-1.3	-0.5	-1.8	-1.7	-1.9	-2.1	0.7	-2.2	-0.5
Long-standing illness, disability or infirmity	2.2	3.4	8.0	2.0	2.4	1.4	2.8	1.0	-1.1	2.1	2.1	1.9	0.1	2.1	0.6
Hearing aid user	2.2	2.5	4.5	-1.9	-1.5	-1.7	-2.1	-1.6	-0.7	-0.8	-1.6	-1.8	1.6	-2.0	0.1
Ever had hysterectomy (womb removed)	2.1	2.3	5.6	2.4	1.6	1.8	1.0	0.0	-0.4	1.0	1.8	2.3	0.8	1.7	-1.5
Illnesses of siblings: Diabetes	2.1	2.6	10.7	1.2	0.8	0.4	1.0	0.3	-0.9	1.9	1.0	1.2	-2.1	2.5	3.3
Medication: Blood pressure	2.1	4.0	8.3	1.8	2.7	0.1	1.5	-0.2	0.1	2.7	2.9	2.3	-2.5	0.8	2.7
Blood White Count	2.0	14.5	33.4	4.0	4.9	3.0	1.3	1.3	-2.4	5.8	5.0	4.7	-2.4	3.3	4.5
Hair/balding pattern: Pattern 2	2.0	2.6	22.5	0.2	1.0	-0.8	0.0	0.4	-1.5	1.3	1.0	0.8	-1.1	0.0	4.7
Had menopause	2.0	2.5	5.2	-2.2	-1.5	-1.6	-0.2	-1.7	2.1	-1.5	-1.5	-1.7	0.3	-2.3	-0.1
Breast cancer (self-reported)	2.0	2.4	12.6	-1.0	-1.6	-0.1	-1.8	-1.2	-1.0	-1.4	-1.5	-0.8	3.5	-0.3	1.6
Ever taken oral contraceptive pill	2.0	2.2	6.1	1.4	2.2	2.5	1.6	-0.1	0.8	1.4	2.0	1.6	1.2	-0.4	0.3
Irritability	2.0	3.4	9.1	-2.5	-1.3	-1.7	-2.0	-1.8	-0.5	-2.1	-1.7	-2.3	-0.5	-3.0	-0.5
Fasting Glucose	1.9	2.3	3.8	1.5	1.8	1.3	1.5	1.0	1.7	1.2	1.9	1.5	-1.9	1.4	-1.1
Impedance of arm (right)	1.9	8.9	16.9	-3.5	-3.6	-4.1	-2.9	-1.0	-1.5	-3.4	-3.7	-3.2	2.8	-3.2	0.9
Heel T-Score	1.8	14.6	96.0	2.0	2.5	-3.2	2.6	4.2	3.2	2.9	2.3	1.4	0.7	2.8	9.8
Maternal smoking around birth	1.8	2.7	9.2	-1.9	-0.5	-2.1	-1.9	-1.3	-1.3	-1.4	-0.9	-1.8	-0.2	-3.0	1.2
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	5.7	2.1	1.5	2.4	1.6	0.3	0.4	1.1	1.5	2.0	1.0	1.3	-0.6
Breastfed as a baby	1.8	2.2	4.8	-1.6	-1.8	-2.2	-1.1	-0.2	1.6	-1.4	-1.7	-1.4	0.4	-0.7	2.1
Illnesses of father: High blood pressure	1.8	2.3	8.6	0.7	1.1	0.0	-0.5	-0.9	-1.4	2.9	1.2	1.1	-2.2	1.5	1.9
Impedance of whole body	1.8	9.2	19.4	-3.7	-3.6	-4.4	-2.7	-0.6	-0.8	-3.9	-3.8	-3.5	2.4	-3.0	0.3
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.3	1.6	1.4	1.5	1.1	1.8	0.6	1.6	1.5	1.6	-0.1	1.3	1.3
Diabetes (father)	1.7	2.1	5.8	1.8	1.4	0.9	1.5	1.6	-0.1	1.6	1.4	1.2	-0.3	2.4	1.7
Knee pain experienced in last month	1.7	2.6	9.3	-1.8	-1.6	-0.5	-2.1	-3.1	-1.4	-1.6	-1.5	-1.4	0.5	-1.1	-1.1
Pain type(s) experienced in last month: Hip pain	1.7	2.2	7.3	-1.5	-0.8	-1.3	-2.0	-2.7	-2.0	-0.7	-1.1	-0.8	1.1	-1.4	1.0
Illnesses of father: None of the above (group 1)	1.6	1.9	12.2	-0.3	-1.2	1.1	0.2	-0.1	-1.7	-1.8	-1.1	-0.6	3.5	-0.6	-0.4
Myopia	1.6	2.3	5.8	1.6	1.2	2.4	0.6	-0.4	-1.0	2.2	1.3	2.0	-1.1	2.0	-0.4
Ovarian Cancer	1.5	2.0	4.4	1.5	1.8	1.3	1.0	-0.0	0.4	1.7	1.7	1.7	-1.4	0.4	2.1
HDL Cholesterol	1.5	2.5	6.6	-2.1	-1.3	-0.7	-1.1	-1.4	-0.6	-1.9	-1.7	-1.5	-0.1	-2.6	-2.2
Triglycerides	1.5	2.4	4.7	1.7	2.1	0.8	2.0	-0.4	1.0	2.0	2.2	1.7	-1.2	1.4	0.4
Current tobacco smoking	1.5	2.4	7.3	-2.2	-1.0	-0.9	-1.7	-1.0	-2.0	-1.3	-1.2	-1.8	0.1	-2.7	-0.5
Father’s age at death	1.5	2.1	8.3	1.6	1.1	1.7	1.2	2.9	0.6	1.2	1.1	1.2	1.3	1.0	1.2
Smoking status: Current	1.5	2.3	7.3	-2.1	-1.1	-1.1	-1.7	-0.8	-1.9	-1.4	-1.3	-1.7	0.4	-2.7	-0.0
Wears glasses or contact lenses	1.5	1.7	3.2	-1.6	-1.4	-1.2	-0.7	-1.6	-0.5	-1.3	-1.8	-1.5	1.8	-0.9	0.0
Alcohol drinker status: Previous	1.5	1.7	3.4	0.9	1.4	1.5	1.9	0.7	1.5	1.7	1.4	0.9	-1.2	1.1	-0.7
Age at First Birth	1.4	2.0	4.8	-1.5	-1.6	-1.7	-1.7	0.8	0.8	-0.2	-1.6	-1.5	1.3	-1.0	2.2
Qualifications: None of the above	1.4	3.0	4.8	-2.2	-1.6	-1.2	-1.5	-2.0	2.1	-2.0	-1.6	-1.6	0.2	-2.0	-2.0
Age at last live birth	1.4	2.1	4.0	2.0	0.9	1.5	1.1	1.8	1.7	1.4	1.2	1.8	1.0	1.6	0.5
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	5.8	-0.8	-1.0	-2.4	-0.7	0.1	2.4	-1.0	-1.0	-1.1	-0.2	-0.4	1.8
Financial difficulties in last 2 years	1.3	1.7	7.4	-1.4	-0.6	0.4	-1.6	-1.9	-2.7	-0.9	-0.8	-1.0	0.6	-1.1	-0.6
Number of full brothers	1.3	1.6	4.9	-1.5	-1.1	-1.1	-1.5	-2.2	-0.8	-1.2	-1.3	-0.8	0.6	-1.3	1.1
Neck or shoulder pain in last month	1.3	1.8	4.7	-1.9	-1.5	-1.5	-1.5	-2.2	0.2	-1.1	-1.5	-1.6	-0.6	0.7	-0.1
Mineral and other dietary supplements	1.3	1.7	4.0	1.4	2.0	1.0	1.5	0.9	-0.4	1.5	1.9	1.7	-0.6	-0.7	0.8
Medication: Aspirin	1.3	1.6	5.2	1.2	0.1	1.3	-0.2	-0.1	2.1	1.3	0.4	1.1	0.5	2.3	1.9
Age started oral contraceptive pill	1.3	1.6	4.2	-1.6	-2.1	-0.9	-1.2	-0.5	1.5	-1.4	-1.5	-1.1	0.7	-0.1	1.1
Average weekly spirits intake	1.2	1.5	10.6	1.3	0.2	1.5	0.0	-1.5	0.4	-0.3	0.1	0.8	0.7	0.5	-3.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.6	-1.6	-1.1	-0.4	-2.1	-1.9	-1.3	-0.9	-1.1	-1.4	0.6	-0.8	0.4
Taking other prescription medications	1.2	1.9	5.3	1.6	1.8	1.4	1.4	-0.4	-0.0	2.3	1.4	1.4	0.0	1.5	1.1
Supplements: Vitamin C	1.2	1.4	5.8	-1.4	-1.4	-0.6	-2.4	-0.2	-0.4	-0.3	-1.2	-0.9	-1.8	0.3	-0.9
Handedness (chirality/laterality): Left-handed	1.2	1.5	3.2	1.6	1.6	1.2	0.1	0.2	0.3	1.8	1.6	1.7	-1.2	1.0	-0.0
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.3	-1.5	-1.7	-1.3	-1.3	-0.1	0.2	-2.1	-1.8	-1.5	0.5	-0.2	-0.1
Ever had prostate specific antigen (PSA) test	1.2	1.4	4.0	-0.6	-1.2	-0.3	-0.6	-1.9	-1.9	-1.1	-1.1	-0.7	2.0	-0.9	0.1
Impedance of leg (right)	1.1	5.1	14.0	-2.6	-2.2	-3.7	-1.6	-0.2	-1.1	-3.2	-2.4	-2.5	2.2	-2.1	1.0
Average weekly fortified wine intake	1.1	1.3	4.6	0.6	1.1	0.6	2.1	1.0	2.0	-0.5	1.1	1.1	-0.6	-0.4	-0.8
Time employed in main current job	1.1	1.2	2.3	-1.0	-0.8	-1.0	-1.4	-0.7	-0.5	-1.5	-1.0	-0.9	1.5	-1.3	1.2
Medication: Ventolin 100micrograms inhaler	1.1	1.5	8.0	-0.8	0.2	-1.5	-1.0	-1.7	-0.5	0.4	-0.2	-0.3	-0.6	-1.4	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.7	-1.6	-1.3	-1.4	-1.2	0.5	-1.4	-1.0	-1.3	-1.6	-0.8	0.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	11.8	-0.9	-0.5	-0.5	-0.5	-0.0	-3.4	0.3	-0.3	-0.8	-1.2	-0.1	0.2
Financial situation satisfaction	1.1	1.3	3.8	1.3	0.9	1.1	1.9	2.0	0.2	1.1	1.1	1.0	-0.4	0.5	-1.1
Systolic Blood Pressure	1.0	5.2	20.4	1.9	3.3	-1.6	1.1	1.8	0.7	2.0	2.7	1.8	-2.2	0.4	4.5
Relative age of first facial hair	1.0	2.0	6.0	1.5	1.8	0.1	1.6	0.6	-0.5	1.6	1.8	1.4	-1.2	0.5	2.4
Age when periods started (menarche)	1.0	2.5	4.5	-1.4	-2.1	-2.1	-1.6	-0.6	-1.4	-1.7	-2.0	-1.7	1.0	-1.1	1.3
Impedance of leg (left)	1.0	4.7	14.0	-2.4	-2.2	-3.7	-1.4	0.4	-0.7	-2.9	-2.4	-2.6	1.7	-1.7	1.2
Hearing difficulty/problems with background noise	1.0	1.6	6.9	-1.3	-0.4	-0.8	-0.0	-0.7	1.2	-0.6	-0.6	-1.2	-2.1	-1.3	-2.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	6.8	0.7	0.7	0.2	0.0	-0.0	-1.0	0.5	0.8	1.0	1.6	0.9	2.6
Pain all over the body in last month	1.0	1.0	6.7	0.2	0.9	0.5	-0.4	-0.8	-2.6	1.3	0.7	0.2	-0.5	0.6	0.9
Medication: Ramipril	1.0	1.3	4.2	0.9	0.8	0.6	-0.2	-0.4	-0.6	2.1	0.7	1.1	-1.2	1.6	1.9
Hip circumference	1.0	4.3	22.2	-1.9	-0.8	0.6	-2.3	-4.7	-1.6	-1.5	-1.0	-1.1	-0.3	-2.0	-3.0
Exposure to tobacco smoke at home	1.0	1.1	3.3	-1.5	-1.1	-0.4	-1.4	-1.8	0.4	-0.6	-1.2	-1.2	0.4	-0.8	-0.6
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	4.5	1.2	1.9	-0.1	1.9	1.7	1.2	2.1	1.7	0.7	-1.3	0.8	1.1
Medication for cholesterol	1.0	1.6	2.8	-1.5	-1.7	-0.1	-1.2	-0.2	-0.1	-1.6	-1.7	-1.5	1.4	-0.9	-1.4
Eye problems/disorders: Glaucoma	1.0	1.1	5.7	-0.4	-0.9	-0.1	-0.2	-0.3	-1.6	-1.5	-0.8	-0.1	2.4	-0.9	0.8
Medication: Paracetamol	1.0	1.5	6.2	-1.2	-1.0	-0.3	-1.7	-1.5	-2.5	-0.3	-0.9	-1.1	-1.3	0.9	0.1
Alcohol drinker status: Never	1.0	1.2	3.8	0.5	-1.0	-1.1	-0.1	1.9	1.9	-0.3	-0.4	-0.1	-1.0	1.9	0.6
Bipolar Disorder (2011)	0.9	0.9	1.7	-1.3	-1.0	-0.4	-0.8	0.1	0.5	-1.0	-1.0	-1.3	0.5	-1.3	-1.0
HbA1C	0.9	1.0	2.4	-1.0	-0.7	-1.5	-1.1	0.8	-1.3	-1.1	-0.7	-0.7	0.6	-1.5	-0.3
Neuroticism (2016)	0.9	1.3	4.7	-2.0	-0.9	-0.3	-0.5	-1.0	-1.4	-0.9	-1.0	-1.1	-0.0	-2.2	-0.4
Vitamin and mineral supplements	0.9	1.2	4.2	0.9	1.0	0.5	1.7	-0.5	0.2	-0.2	1.0	0.7	2.1	-0.9	1.4
Severe depression (siblings)	0.9	1.0	2.5	-1.0	-1.0	-0.8	-0.7	-0.4	-0.1	-1.4	-1.2	-1.6	1.2	-0.2	-1.1
Trunk fat percentage	0.9	3.5	18.7	-2.0	-1.5	-0.9	-2.2	-4.3	-0.1	-1.7	-1.7	-1.6	-0.1	-1.4	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	11.8	0.6	1.4	-1.3	1.0	2.0	-0.4	0.7	1.1	0.5	0.3	1.4	3.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.9	-0.9	-1.3	0.0	-1.4	-1.6	-0.9	-1.7	-1.1	-1.0	0.1	-0.3	-0.5
Happiness	0.9	1.0	3.8	-1.1	-0.2	-1.2	-0.8	0.7	-0.9	-0.6	-0.3	-1.0	-1.9	-1.5	0.7
Medication: Amlodipine	0.9	1.3	3.4	0.8	1.8	-0.4	0.8	-0.8	-0.3	1.6	1.6	1.0	-1.7	0.3	0.8
Birth weight	0.9	1.9	6.2	-1.1	-1.3	-2.5	-2.1	0.9	1.2	-1.4	-1.3	-1.4	-0.2	-1.0	-0.5
Medication: Aspirin	0.9	1.2	4.4	0.8	-0.2	1.0	-0.5	-0.1	1.9	1.2	0.1	0.6	-0.1	2.1	1.4
Osteoporosis (self-reported)	0.9	1.2	7.7	-0.6	-0.9	0.4	-0.5	0.2	-1.0	-1.5	-0.6	-0.6	0.4	-0.6	-2.8
Cholesterol lowering medication	0.9	1.3	2.6	1.1	1.4	-0.4	0.9	0.1	-0.6	1.2	1.4	1.2	-1.4	1.2	1.6
Supplements: Calcium	0.9	1.0	2.3	-1.5	-1.2	-1.1	-1.2	0.8	-0.8	-0.8	-1.4	-1.3	-0.0	-0.7	-0.2
Basal cell carcinoma (self-reported)	0.9	1.0	2.3	-1.3	-1.3	-0.1	-1.3	-1.4	-1.5	0.4	-1.1	-1.2	-0.1	0.2	0.4
Mean Putamen Volume	0.8	0.9	2.2	-1.2	-0.4	-1.1	-0.8	0.4	0.9	-0.7	-0.8	-1.4	-1.5	-0.8	-0.9
Height	0.8	15.4	39.7	-4.4	-3.7	-3.8	-5.1	-3.6	-1.2	-4.4	-3.8	-4.3	1.3	-6.3	-1.6
Smoking Status	0.8	2.0	14.4	-1.1	0.5	-0.4	-0.5	-0.8	-2.0	-0.8	0.2	-0.5	1.2	-3.8	-0.5
Cardiovascular Disease	0.8	2.7	9.0	1.6	3.0	-1.0	2.1	0.4	-0.2	1.8	2.4	1.6	-0.9	0.3	1.5
Hypothyroidism (self reported)	0.8	1.9	5.2	1.5	1.8	0.1	1.7	1.2	0.7	2.3	1.7	0.9	-1.1	0.7	1.4
Alcohol usually taken with meals	0.8	1.3	5.2	1.3	0.8	0.3	-0.0	2.2	0.8	0.8	1.0	1.1	0.2	-0.1	2.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	5.8	1.1	0.1	0.6	1.2	0.3	-1.0	-0.3	0.0	0.5	2.4	-0.2	1.3
Illnesses of mother	0.8	1.0	2.9	-0.9	-1.7	-0.4	-1.0	-0.6	-1.0	-1.2	-1.2	-0.9	1.0	0.3	0.6
Birth weight of first child	0.8	1.4	2.3	1.0	1.3	1.0	1.4	1.5	0.7	0.6	1.4	1.0	-1.3	1.1	-1.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	6.6	0.4	0.9	1.0	0.9	-0.3	0.8	0.3	0.8	1.0	-0.3	0.7	-2.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.7	-1.0	-0.9	-0.4	-1.6	-0.7	0.5	-1.5	-0.9	-0.9	0.7	-1.0	-0.1
Osteoarthritis (self-reported)	0.8	1.0	4.1	0.3	1.5	0.7	0.8	0.3	1.7	0.0	0.9	0.4	2.0	0.3	-0.3
Medication: Lisinopril	0.8	1.0	2.7	0.8	1.6	-0.4	1.5	0.9	0.7	0.8	1.6	0.8	-1.0	0.3	0.0
Ever depressed for a whole week	0.8	1.0	7.4	-0.7	-0.9	-0.3	-0.3	-0.4	-0.8	-1.0	-0.7	-0.7	2.7	-0.4	0.6
Primary Biliary Cirrhosis	0.7	1.0	3.5	0.9	1.2	0.2	1.9	1.2	1.1	0.5	1.2	1.0	0.6	-0.5	0.1
Hearing difficulty/problems: Yes	0.7	1.0	6.8	0.3	1.0	0.6	0.3	-0.3	0.8	1.1	1.0	0.5	-0.7	-0.5	-2.6
Townsend deprivation index at recruitment	0.7	1.0	4.2	0.3	0.8	0.3	0.9	0.2	1.0	0.7	1.0	0.7	-2.0	-0.2	-1.7
Relative age voice broke	0.7	1.0	4.0	1.6	1.1	0.8	2.0	0.6	-0.5	0.1	1.2	1.2	0.1	0.1	-0.6
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.3	0.9	1.4	0.5	0.2	0.1	-0.1	0.4	1.3	0.6	-1.5	-0.7	-1.2
Medication: Levothyroxine sodium	0.7	1.2	3.1	0.6	1.2	-0.9	1.7	1.4	1.4	1.0	1.0	0.1	-1.8	-0.3	-0.3
Waist circumference	0.7	2.7	5.6	1.9	2.1	1.9	1.0	-0.8	-0.1	2.4	2.1	1.9	-0.5	2.0	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	8.4	0.8	1.3	-0.9	0.9	1.9	-0.6	0.7	1.0	0.5	0.3	1.5	2.9
Worrier / anxious feelings	0.7	1.2	3.9	-1.6	-1.2	-2.0	-1.0	-0.5	-0.3	-1.1	-1.1	-1.4	-0.4	-1.0	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	4.2	0.6	0.8	0.9	0.4	0.3	-1.3	0.8	0.7	0.6	-0.2	0.3	-2.0
Depression (self-reported)	0.7	0.8	2.0	-0.2	-1.1	-0.4	-1.3	-1.4	-1.0	-1.3	-1.1	-0.4	0.7	-0.2	0.0
Loud music exposure frequency	0.7	0.8	3.1	0.7	0.5	0.1	-0.3	0.4	-1.8	0.9	0.7	0.8	0.8	1.1	1.3
Medication: Paracetamol	0.7	1.2	3.8	-0.5	-0.4	0.6	-1.5	-1.5	-2.0	0.3	-0.4	-0.5	-1.2	1.7	-0.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	4.7	-0.4	-0.4	-0.6	-0.5	0.3	2.2	-0.5	-0.7	-0.7	1.5	-0.9	0.0
High blood pressure (siblings)	0.7	1.0	5.2	0.6	1.6	-0.2	2.3	0.2	0.4	0.0	1.2	0.7	0.1	-1.3	-0.7
Body fat percentage	0.7	2.7	18.6	-1.6	-1.0	-0.5	-1.8	-4.3	-0.2	-1.2	-1.2	-1.2	-0.3	-0.9	-0.8
Exposure to tobacco smoke outside home	0.7	1.0	4.3	1.1	-0.6	1.6	0.1	0.8	0.7	0.6	0.0	0.8	0.9	2.1	-0.4
Age at first live birth	0.7	1.3	3.6	1.1	0.3	0.8	-0.3	1.3	1.6	0.3	0.6	1.2	1.9	1.4	1.3
Eye problems/disorders: None of the above	0.7	0.8	3.6	-0.4	0.1	-0.3	-0.5	-0.3	1.7	0.2	-0.1	-0.6	-0.7	-1.1	-1.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.5	1.1	0.6	1.2	0.2	0.9	-0.4	0.9	0.8	1.1	1.1	1.2	0.5
Medication: Allopurinol	0.7	0.9	4.1	1.0	1.3	0.3	1.1	-0.1	-0.3	0.8	1.2	0.6	-0.3	2.0	-0.4
Smoking status: Previous	0.7	1.0	3.3	0.9	1.6	0.2	1.8	0.0	-0.2	0.8	1.2	0.9	0.9	-1.3	0.1
Friendships satisfaction	0.7	0.9	2.6	0.7	1.0	0.6	0.0	0.8	-1.6	1.0	1.3	0.8	-1.2	0.2	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.5	-0.6	-0.2	-0.4	-0.8	-1.6	1.2	0.3	-0.2	-0.4	-0.8	1.0	1.6
Number of self-reported non-cancer illnesses	0.7	1.3	5.1	1.4	1.1	0.4	1.5	-0.5	0.2	1.2	0.9	0.9	0.3	2.3	1.3
Guilty feelings	0.7	1.1	5.5	-0.4	0.2	0.6	1.2	1.0	-0.1	-1.6	-0.1	-0.4	1.3	-0.6	-2.4
Medication: Bendroflumethiazide	0.7	1.1	4.6	0.1	1.7	-0.7	0.9	-0.1	1.1	0.9	1.5	0.2	-2.1	-0.7	0.5
Diastolic blood pressure, automated reading	0.7	2.1	12.3	-0.0	0.5	-2.4	-0.8	0.4	2.1	0.2	0.4	0.1	-1.1	-0.8	3.5
Depression (Nagel 2018)	0.6	0.9	3.8	-1.3	-0.7	-0.5	-1.9	-0.8	-0.3	-1.0	-0.9	-1.0	0.4	-0.7	0.5
Ulcerative Colitis (UC)	0.6	1.1	2.6	-1.1	-1.0	-1.6	0.1	-1.2	-1.6	-0.4	-1.0	-1.4	0.3	-0.4	1.1
Coronary Artery Disease (CAD)	0.6	0.7	3.5	-0.6	1.0	-0.7	-0.0	0.4	0.7	0.2	0.4	-0.3	0.0	-1.6	1.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.4	0.2	0.7	-1.0	1.0	1.5	0.3	0.7	0.2	0.1	-0.2	-0.6	1.5
Blood Red Count	0.6	5.8	17.4	2.6	3.0	1.8	2.4	1.0	4.2	2.3	3.0	2.3	-2.1	1.7	0.4
Number of treatments/medications taken	0.6	1.1	2.8	1.2	1.2	0.3	0.5	-1.1	0.6	1.1	1.1	1.0	0.1	1.7	1.5
Sensitivity / hurt feelings	0.6	1.0	2.1	-1.5	-0.6	-0.5	0.6	-1.3	-0.3	-1.1	-0.7	-1.2	-1.4	-1.4	-1.1
Systolic blood pressure, automated reading	0.6	1.8	8.5	-0.5	0.2	-2.5	-0.9	-0.2	2.0	-0.3	-0.1	-0.6	-0.6	-1.0	2.9
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.2	1.3	1.4	0.4	1.8	0.7	-1.4	0.8	1.3	0.9	-1.7	0.7	-0.7
Supplements: Glucosamine	0.6	0.8	3.9	-0.5	-0.4	0.6	-0.5	-2.0	1.3	-0.2	-0.2	-0.5	1.5	0.5	-0.9
Had other major operations	0.6	0.8	3.6	-0.7	-0.6	-0.9	-1.2	-0.8	-1.1	0.3	-0.6	-0.5	-0.0	-0.3	1.9
Forced vital capacity (FVC)	0.6	2.5	6.9	-1.4	-2.6	-0.6	-1.2	1.0	-0.0	-1.9	-2.4	-2.1	1.8	-0.7	-1.0
Fluid intelligence score	0.6	1.3	3.7	1.7	1.0	1.6	1.9	1.3	0.4	1.0	1.0	1.1	0.0	0.6	-0.4
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.0	-1.3	-2.2	-1.2	-1.4	0.8	-0.3	-1.8	-2.1	-1.9	1.7	-0.5	-0.6
Medication: Cholesterol lowering	0.6	1.0	4.1	1.0	0.5	0.4	0.2	0.5	1.1	1.0	0.4	0.9	0.8	1.4	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	6.1	-0.6	-0.7	-0.5	-0.6	-1.7	-2.5	-0.4	-0.7	-0.5	0.1	-0.5	-0.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	4.1	1.0	-0.5	0.6	0.4	2.0	-0.2	0.1	-0.5	0.4	1.4	2.0	0.1
Glaucoma (self-reported)	0.6	0.7	3.7	0.0	-0.7	-0.5	0.1	0.1	-1.1	-1.5	-0.5	0.1	1.9	0.2	0.3
Wheeze or whistling in the chest in last year	0.6	1.1	2.7	-0.7	-0.6	-1.6	-1.7	-1.2	-1.6	-0.1	-1.0	-0.8	-0.5	-0.1	1.2
Number of children fathered	0.6	0.7	4.5	0.3	-0.2	1.2	0.6	-0.1	0.6	-0.5	-0.3	-0.2	1.0	0.5	-2.1
Emphysema/chronic bronchitis	0.6	0.7	2.7	-0.8	-1.3	0.1	-1.6	-1.2	0.4	-0.1	-1.1	-0.6	-0.6	-0.1	-0.2
Illnesses of father: Heart disease	0.6	0.8	2.9	0.4	1.0	-0.1	0.1	0.9	1.5	0.7	0.7	0.6	-1.7	-0.5	-0.9
Commuting to job workplace: Walk	0.6	0.6	1.5	-1.1	-0.7	-0.0	-0.0	-0.8	-0.7	-1.2	-1.1	-1.1	0.2	-0.3	-0.7
Mother’s age at death	0.6	0.8	3.9	0.5	1.3	-0.1	2.0	0.5	0.2	0.4	1.1	0.3	-0.7	-0.3	-0.7
Ever smoked	0.6	1.0	6.9	-0.1	1.1	-0.1	1.0	0.4	-1.0	0.3	0.8	0.0	0.8	-2.6	-0.5
Heart disease (siblings)	0.6	0.7	2.0	-0.5	-0.9	-0.9	-0.3	0.9	-0.8	-0.1	-1.1	-0.6	-1.4	1.0	0.9
Intelligence (Savage-Jansen 2018)	0.5	1.4	3.2	1.2	1.1	0.9	1.8	1.1	1.2	0.9	1.2	1.0	-1.5	0.6	-1.3
Allergy or Eczema	0.5	1.3	4.8	0.8	1.4	-0.2	1.4	-0.4	-1.7	0.9	1.3	0.5	-2.2	0.5	-0.4
Supplements: Zinc	0.5	0.6	2.1	-0.4	0.9	-1.0	0.1	1.4	-0.5	0.3	0.6	-0.0	-1.3	0.2	0.6
Pack years adult smoking proportion	0.5	0.8	2.5	0.4	1.2	1.6	0.7	1.0	0.5	1.2	1.0	0.6	-0.5	0.5	0.5
Hand grip strength (right)	0.5	1.3	2.6	-0.8	-1.1	-1.5	-1.6	1.0	0.1	-1.4	-1.1	-1.2	1.2	-1.0	1.2
Fed-up feelings	0.5	0.8	6.4	-0.2	0.7	1.0	-0.3	-0.4	-2.5	0.2	0.7	0.5	-0.2	-1.0	-0.0
High blood pressure	0.5	1.3	4.1	-0.2	1.4	-2.0	-0.1	-0.7	0.1	0.8	1.0	0.0	-1.9	-0.2	1.9
Medication: Atenolol	0.5	0.6	1.5	1.0	0.9	0.4	1.2	-0.3	-0.2	0.6	0.9	0.9	0.0	1.1	1.0
Trunk fat mass	0.5	2.2	16.7	-1.2	-0.8	0.2	-1.8	-4.1	-0.4	-0.7	-0.9	-0.8	-0.2	-0.7	-1.0
Past tobacco smoking	0.5	0.9	5.4	-0.2	-1.4	0.1	-1.1	0.0	0.5	-0.5	-0.9	-0.4	-1.0	2.3	-0.1
Illnesses of siblings	0.5	0.7	2.1	-0.5	-0.6	0.6	-1.1	-0.8	-0.0	-1.1	-0.3	-0.5	1.4	-0.9	-1.3
Trunk fat-free mass	0.5	2.7	8.3	2.1	1.7	2.9	0.2	-1.1	-1.5	2.2	2.0	2.0	-0.5	1.0	-0.3
Noisy workplace	0.5	0.6	3.1	-1.0	-0.0	-0.8	-0.2	-0.1	-0.8	-1.1	-0.1	-0.2	1.8	-0.8	0.6
Mouth/teeth dental problems: Dentures	0.5	0.9	4.0	1.2	0.3	0.4	0.9	0.8	0.4	0.5	0.4	0.2	-0.3	1.6	-2.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	4.8	0.1	-0.1	1.1	0.6	-0.0	0.3	-0.5	0.0	-0.1	0.3	0.8	-2.2
Medication: Lansoprazole	0.5	0.5	2.2	0.3	0.4	0.4	0.0	-0.2	-0.2	1.5	0.5	0.5	-1.3	1.1	0.3
Trunk predicted mass	0.5	2.8	8.4	2.1	1.7	2.9	0.4	-1.0	-1.4	2.1	2.1	2.0	-0.4	1.0	-0.2
Length of working week for main job	0.5	0.5	2.4	-0.3	-0.8	-0.7	0.2	1.5	1.1	-0.5	-0.6	-0.6	-0.5	-0.6	-0.3
Tense / ‘highly strung’	0.5	0.8	2.7	-0.7	-0.8	-0.6	0.1	0.4	-0.8	-1.3	-0.6	-0.6	-0.9	-1.3	-1.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	3.9	-1.1	0.0	-0.6	0.3	0.6	-0.0	-0.4	-0.2	-0.7	0.4	-2.0	-0.5
Arm fat-free mass (right)	0.5	2.4	7.9	1.6	1.7	2.8	0.4	-1.3	-0.7	1.7	1.9	1.7	-1.3	0.9	-1.2
Shortness of breath walking on level ground	0.5	0.6	2.3	0.2	0.6	0.8	-0.0	-1.4	-0.5	-0.1	0.3	0.8	1.5	-0.4	-0.3
Medication for pain relief, constipation, heartburn	0.5	0.9	4.2	-0.0	0.5	-1.2	1.2	1.8	-0.5	-0.1	0.4	-0.0	-0.0	-2.1	0.1
Heart disease (mother)	0.5	0.7	2.9	-0.5	0.5	-1.1	0.2	0.2	0.2	-0.2	0.1	-0.3	-1.0	-1.7	-1.4
Arm predicted mass (right)	0.5	2.5	8.0	1.8	1.8	2.8	0.5	-1.3	-0.6	1.9	2.0	1.8	-1.1	1.1	-0.8
Alcohol intake frequency.	0.5	1.2	3.8	1.0	0.9	0.7	0.3	0.8	0.8	1.2	1.3	1.3	-0.4	1.9	1.2
Number of full sisters	0.5	0.6	3.0	-0.5	-0.6	-0.9	-0.7	-0.2	0.2	-0.6	-0.5	-0.5	-1.7	-0.8	0.1
Family relationship satisfaction	0.5	0.6	3.3	-0.3	-0.2	-0.3	-0.6	0.2	-1.3	0.4	-0.0	0.1	-1.0	0.4	1.8
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.4	0.8	0.6	0.5	1.5	0.9	0.4	0.4	0.6	0.4	-0.9	0.0	-0.9
Hypertension (Self-reported)	0.5	1.4	4.5	0.2	1.7	-1.7	0.4	-0.4	0.0	1.4	1.3	0.3	-1.7	0.3	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.5	-0.5	0.0	-0.8	-1.1	-1.6	0.8	0.9	-0.3	-0.3	-0.0	0.2	1.0
Qualifications: nursing, teaching	0.5	0.7	4.6	0.9	-0.1	-0.3	0.8	-0.1	1.2	0.7	0.0	0.5	-0.1	2.1	-0.5
High cholesterol (Self-reported)	0.5	0.8	1.6	1.2	0.7	-0.5	1.2	0.4	1.1	0.7	0.7	1.0	-0.2	1.1	1.3
Arm fat-free mass (left)	0.5	2.4	6.5	1.6	1.9	2.5	0.3	-1.5	-1.0	1.9	2.1	1.8	-1.2	0.6	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	3.2	0.6	0.1	0.1	1.0	0.6	0.9	0.1	0.3	0.3	-1.1	-0.2	-1.8
Arm predicted mass (left)	0.5	2.8	7.8	1.8	2.0	2.8	0.4	-1.6	-1.0	1.9	2.3	2.0	-1.0	0.5	-0.8
Alzheimer’s Disease (in father)	0.4	0.4	2.1	0.3	0.3	0.1	-0.2	-0.6	-1.4	0.5	0.1	0.5	1.1	-0.7	-0.2
Body Mass Index (BMI) (2010)	0.4	0.6	1.9	0.8	0.6	1.4	0.6	-0.8	-0.1	0.6	0.5	0.6	-0.8	0.4	-1.0
Crohns Disease (2012)	0.4	0.6	1.8	0.1	0.4	-0.5	0.4	1.2	1.4	-0.4	0.3	-0.1	1.1	-1.3	0.5
LDL Cholesterol	0.4	0.6	3.1	0.3	1.1	0.4	1.8	-0.3	-0.4	0.5	0.9	0.6	-0.7	-0.6	-0.5
Lupus	0.4	0.6	2.6	-0.9	-1.1	-0.6	-0.8	0.1	-0.2	-1.6	-1.2	-0.3	0.6	0.1	-0.3
Rheumatoid Arthritis	0.4	0.6	3.7	-0.5	-0.2	0.3	0.1	-1.9	0.5	-0.8	-0.3	-0.3	0.0	-0.6	-1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.3	0.0	0.5	0.0	1.5	1.3	-0.6	-0.2	0.2	-0.2	-0.3	-0.4	-1.2
Multivitamins +/- minerals	0.4	0.5	1.1	-0.8	-0.9	-1.0	-0.4	0.8	0.4	-0.2	-1.0	-0.8	-0.1	0.5	-0.5
Stomach or abdominal pain in last month	0.4	0.5	1.5	0.7	0.7	0.6	0.8	0.8	-0.9	0.6	0.7	0.4	0.6	1.2	0.5
Sitting height	0.4	2.9	11.2	-0.5	-0.9	1.9	-2.5	-2.1	-3.3	-1.1	-0.8	-0.4	1.6	-0.8	-1.8
Body mass index (BMI)	0.4	1.8	8.0	0.7	1.2	2.0	0.0	-2.8	0.2	1.4	1.2	1.0	-1.4	1.1	-0.7
Heart attack	0.4	0.6	2.5	0.0	-0.3	0.6	0.2	0.9	1.1	0.7	-0.2	-0.2	-0.3	1.6	-1.1
Medication: Simvastatin	0.4	0.6	3.4	0.3	0.3	-1.2	-0.3	0.6	-0.2	0.2	0.3	0.2	-0.7	1.2	1.8
Neuroticism score	0.4	0.8	1.8	-1.0	0.1	0.1	0.3	-0.7	-1.2	-1.0	0.0	-0.5	-1.2	-1.4	-1.3
Arm fat percentage (right)	0.4	1.4	14.5	-0.6	-0.1	0.6	-1.1	-3.8	-0.2	0.2	-0.2	-0.2	-0.7	0.0	-0.4
Falls in the last year	0.4	0.6	3.7	0.1	-1.0	-0.0	-0.0	-0.7	0.9	-1.9	-0.7	0.3	0.7	-0.1	-0.4
Asthma	0.4	0.8	3.7	0.9	0.8	0.2	0.0	-1.1	-0.6	0.9	0.5	0.6	-0.5	1.0	1.9
Prospective memory result	0.4	0.4	1.3	-0.1	-0.9	-0.6	-0.7	-0.6	1.1	0.4	-0.5	-0.2	-0.8	0.8	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.8	-0.8	-1.6	-0.8	-1.0	0.6	0.9	-1.2	-1.4	-1.1	1.7	-0.4	-0.5
Standing height	0.4	4.3	9.9	-1.7	-2.4	-1.6	-3.1	-1.4	-2.3	-2.1	-2.1	-1.8	1.9	-2.9	-0.2
Forced vital capacity (FVC), Best measure	0.4	1.5	4.5	-0.9	-1.9	0.0	-1.0	0.5	1.0	-1.3	-1.7	-1.2	2.1	-0.3	-0.9
Leg fat percentage (right)	0.4	1.5	14.0	-0.8	-0.2	0.4	-1.1	-3.7	-0.3	-0.7	-0.3	-0.6	-0.2	-0.1	-0.8
Worry too long after embarrassment	0.4	0.6	1.6	-0.7	-0.2	0.0	1.0	1.0	-0.7	-1.3	-0.3	-0.7	-0.4	-1.0	-0.8
Health satisfaction	0.4	0.5	1.8	0.4	1.2	0.3	0.3	-0.7	-1.3	0.6	1.1	0.5	-0.5	0.1	-0.4
Qualifications: College or University degree	0.4	1.3	3.0	1.7	1.1	0.5	0.5	-0.1	-1.3	1.2	1.0	1.4	-0.0	1.7	1.7
Medication: Blood pressure	0.4	0.6	4.0	0.5	1.0	-0.4	0.1	-0.0	-0.0	0.9	0.7	0.5	0.0	0.5	2.0
Medication: Ibuprofen	0.4	0.4	2.1	-0.0	-0.3	1.0	0.2	-0.0	0.5	-0.3	-0.2	-0.4	0.1	1.1	-1.5
Medication: Omeprazole	0.4	0.5	1.9	0.1	1.0	0.3	-0.2	-1.4	-0.0	0.4	0.6	0.4	-1.3	0.1	-0.9
Medication: Seretide 50 evohaler	0.4	0.5	2.1	0.2	-0.1	0.4	-1.5	-1.2	-0.5	0.1	-0.0	0.6	-1.1	0.3	0.6
Mean time to correctly identify matches	0.4	0.7	5.9	0.5	0.2	-0.7	2.4	0.4	0.8	-0.3	0.3	0.5	-0.2	-0.1	0.9
Whole body fat mass	0.4	1.7	16.1	-0.7	-0.3	0.7	-1.4	-4.0	-0.4	-0.4	-0.4	-0.4	-0.2	-0.4	-0.7
Leg fat mass (right)	0.4	1.5	13.8	-0.2	0.4	1.3	-0.7	-3.7	-0.6	0.1	0.4	0.1	-0.8	-0.1	-0.9
Chest pain or discomfort	0.4	0.6	4.2	-0.4	-0.5	-0.7	0.5	2.1	0.1	-0.1	-0.5	-0.6	0.1	0.7	0.6
Whole body fat-free mass	0.4	2.5	8.4	1.7	1.5	2.9	0.2	-1.5	-1.3	2.0	1.9	1.8	-0.9	0.7	-0.7
Arm fat percentage (left)	0.4	1.5	14.8	-0.7	-0.3	0.7	-1.2	-3.9	0.0	0.0	-0.4	-0.3	-0.6	0.2	-0.6
Average weekly red wine intake	0.4	0.6	3.6	0.5	-0.0	1.4	0.6	0.0	-0.4	-0.6	0.1	0.5	1.9	-0.7	0.2
Whole body water mass	0.4	2.5	8.6	1.7	1.6	2.9	0.2	-1.5	-1.2	2.0	1.9	1.8	-0.8	0.6	-0.8
Average weekly champagne plus white wine intake	0.4	0.5	1.1	-0.6	-1.0	-0.9	-0.6	-0.1	0.7	0.5	-0.9	-1.1	0.8	-0.4	-0.2
Number of operations (self-reported)	0.4	0.6	1.8	0.4	0.1	1.0	0.2	-0.9	-1.3	0.4	-0.0	0.1	0.5	0.8	-1.3
Average weekly beer plus cider intake	0.4	0.6	3.2	-0.3	-0.7	-0.1	-0.3	1.1	-0.8	0.2	-0.5	-0.7	-0.5	1.0	-1.8
Risk taking	0.4	0.5	2.1	-0.6	0.2	-0.4	-0.6	-0.5	-1.2	-0.1	0.1	-0.5	-1.5	-1.0	-0.5
Vascular/heart problems diagnosed by doctor	0.4	1.2	5.2	0.6	-0.8	2.3	0.5	0.9	-0.7	-0.4	-0.5	0.3	2.0	0.4	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.4	0.2	1.1	0.6	0.1	-0.9	0.4	0.7	0.6	0.7	-1.2	0.3	-0.8
Pain experienced in last month	0.4	0.6	4.0	0.1	-0.6	-0.4	0.4	2.0	1.2	-0.5	-0.4	-0.2	-0.1	-0.1	1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.2	0.0	-0.3	0.7	0.1	0.7	0.9	0.7	-0.2	-0.1	-0.2	1.5	-1.1
Leg fat mass (left)	0.4	1.4	12.2	-0.1	0.4	1.3	-0.7	-3.5	-0.4	0.3	0.4	0.1	-1.1	0.2	-0.8
Bipolar Disorder (2018)	0.3	0.5	1.4	0.9	0.7	0.8	0.5	1.2	-0.8	0.4	0.8	0.6	0.1	0.3	-0.5
Schizophrenia (2018)	0.3	0.6	2.5	-0.2	-1.1	0.2	0.2	0.9	0.1	-0.6	-0.9	-0.4	1.1	1.6	0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.7	0.0	0.2	0.4	0.1	-0.3	-1.1	0.8	-0.1	0.0	-0.9	0.6	1.3
Alzheimer’s Disease (including proxy)	0.3	0.5	2.9	-0.1	0.2	-0.0	-0.2	0.2	-1.0	-0.2	0.1	0.1	1.3	-1.7	0.4
Irritable Bowel Disease (IBD)	0.3	0.7	2.0	-0.7	-0.4	-1.4	0.4	-0.6	-1.2	-0.0	-0.5	-0.9	0.7	-0.9	1.4
Reaction Time	0.3	0.5	4.1	0.4	0.1	-0.7	2.0	0.9	0.1	-0.2	0.1	0.4	0.1	0.0	0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.0	1.2	0.3	1.4	1.0	-0.1	0.2	0.9	0.7	0.9	0.4	0.7	-0.5
Ulcerative Colitis	0.3	0.5	1.7	0.1	-0.1	-0.4	1.2	-0.4	-0.9	0.0	-0.0	-0.2	1.0	0.3	1.3
Respiratory disease	0.3	0.6	1.7	0.8	0.5	0.7	-0.0	-0.3	-0.7	0.9	0.5	0.6	-0.7	1.0	1.3
Lung FEV1/FVC ratio	0.3	1.6	7.6	-1.3	-0.8	-2.8	-1.2	-0.9	-0.1	-1.7	-0.8	-1.2	-0.4	-1.4	-0.4
Lung FVC	0.3	1.4	3.5	-0.5	-1.8	1.3	-0.1	0.5	0.7	-0.1	-1.5	-1.0	1.5	1.2	-1.9
Neuroticism	0.3	0.7	2.8	-0.9	-0.0	0.0	0.2	-0.1	-1.7	-0.7	0.1	-0.5	-1.7	-1.2	-0.5
Chronotype (morning person)	0.3	0.6	3.5	0.7	0.9	0.5	0.3	0.8	0.3	0.3	0.8	0.5	-0.3	0.5	1.9
Hair Pigment	0.3	7.4	24.5	1.5	3.7	0.4	2.2	0.6	-1.6	4.4	3.4	1.8	-5.0	1.6	1.9
Medication for hormone replacement therapy	0.3	0.4	3.3	0.1	-0.0	-0.2	0.4	0.1	0.8	0.2	-0.2	-0.2	0.0	0.1	-1.8
Leg fat-free mass (left)	0.3	1.8	6.4	1.1	1.0	2.5	-0.2	-1.9	-0.8	1.4	1.3	1.3	-1.2	0.3	-1.4
Qualifications: CSEs or equivalent	0.3	0.4	3.1	0.2	0.0	0.1	0.6	0.5	-0.3	-0.3	-0.1	-0.2	-0.7	0.2	-1.8
Serious illness, injury or assault to yourself	0.3	0.4	2.1	0.0	0.1	0.4	0.3	1.1	-1.4	0.2	0.3	-0.0	0.6	-0.3	-0.8
High blood pressure (mother)	0.3	0.4	1.7	0.3	0.7	-0.1	0.6	-0.9	-0.0	-0.1	0.5	0.4	-1.3	0.4	-0.8
Leg predicted mass (left)	0.3	1.8	6.2	1.1	1.0	2.5	-0.2	-1.9	-0.8	1.4	1.3	1.3	-1.1	0.2	-1.3
Number of incorrect matches in round	0.3	0.6	1.5	0.8	0.2	1.2	0.1	-0.4	1.2	0.8	0.4	1.1	0.3	1.0	0.4
Allergy	0.3	0.8	3.0	-1.1	-0.9	0.0	-0.9	-0.3	1.7	-0.7	-0.8	-0.5	1.2	-0.9	-0.1
Weight	0.3	1.4	10.8	-0.1	0.2	1.3	-1.3	-3.3	-1.0	0.4	0.3	0.2	-0.6	-0.3	-0.9
Pulse wave Arterial Stiffness index	0.3	0.4	1.5	-0.2	-0.7	-0.3	-0.2	-1.2	-0.5	-0.2	-0.4	-0.4	0.9	-0.9	-0.0
Arm fat mass (right)	0.3	1.3	11.7	-0.3	0.2	1.1	-0.9	-3.4	-0.2	0.6	0.2	0.1	-0.9	0.1	-0.5
Blood clot in the leg (DVT)	0.3	0.4	2.3	0.3	-0.4	-0.2	0.7	0.3	0.9	-0.1	-0.1	-0.1	-0.9	-0.3	-1.5
Headache pain in last month	0.3	0.6	1.9	-0.6	-0.9	-0.2	-0.6	-0.4	0.1	-1.0	-1.1	-0.8	1.4	-0.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.4	-0.9	-0.9	-0.0	-0.3	0.2	-0.1	-1.0	-0.7	-0.7	-0.2	-0.5	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	2.6	0.0	-0.4	0.0	-0.6	-0.4	-0.2	0.3	-0.4	0.3	0.6	1.6	-0.2
Pulse wave peak to peak time	0.3	0.3	1.7	0.2	0.6	0.2	-0.0	1.3	0.3	0.2	0.4	0.4	-0.9	0.7	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.0	-0.2	-0.5	-1.0	-0.7	0.3	0.0	0.2	-0.5	-0.6	-0.4	0.4	0.9
Overall health rating	0.3	0.7	3.1	-0.4	0.1	0.6	-0.8	-1.1	-1.8	-0.1	-0.0	-0.3	1.1	0.3	1.0
Had major operations	0.3	0.4	0.7	-0.7	-0.6	-0.8	0.0	0.7	-0.6	-0.7	-0.4	-0.8	-0.6	-0.4	-0.8
Leg pain on walking	0.3	0.3	1.3	-0.1	0.5	0.1	-0.2	-1.1	-1.1	0.6	0.5	0.4	-0.5	0.3	0.1
Leg fat-free mass (right)	0.3	1.8	6.7	1.2	1.0	2.6	-0.1	-1.4	-0.7	1.7	1.3	1.3	-1.3	0.5	-1.2
Loneliness, isolation	0.3	0.4	1.9	-0.7	0.9	0.2	0.0	-0.5	-1.2	-0.2	0.5	-0.1	-0.2	-1.4	0.2
Asthma (self-reported)	0.3	0.6	3.0	0.7	0.5	-0.1	-0.1	-0.9	-0.2	0.7	0.2	0.3	-0.7	1.0	1.7
Leg predicted mass (right)	0.3	1.8	6.8	1.2	1.0	2.6	-0.0	-1.4	-0.7	1.7	1.3	1.3	-1.3	0.5	-1.2
Arm fat mass (left)	0.3	1.4	13.4	-0.2	0.2	1.3	-1.1	-3.7	0.0	0.4	0.2	0.2	-0.7	0.2	-0.4
Miserableness	0.3	0.5	1.1	0.0	1.0	0.6	0.5	-0.4	-0.9	0.5	0.9	0.4	-0.9	-0.1	-1.0
Commuting to job workplace: Public transport	0.3	0.4	1.1	0.3	0.9	-0.1	0.4	-0.4	-1.1	1.0	0.7	0.4	-0.7	0.7	0.3
Basal metabolic rate	0.3	1.9	6.2	1.2	1.2	2.5	-0.3	-2.0	-1.2	1.6	1.5	1.4	-0.9	0.4	-0.9
Leg fat percentage (left)	0.3	1.1	10.0	-0.6	-0.1	0.3	-1.0	-3.2	-0.0	-0.4	-0.3	-0.5	-0.6	0.2	-0.4
Fractured/broken bones in last 5 years	0.3	0.4	2.1	-0.7	-0.1	-0.2	0.0	0.1	0.7	0.4	-0.1	-0.6	-1.4	0.3	-1.2
Commuting to job workplace: Cycle	0.3	0.4	1.9	0.6	0.5	0.3	-0.1	0.6	0.7	0.6	0.3	0.1	-0.6	0.7	-1.4
Pack years of smoking	0.3	0.4	1.6	0.1	0.7	1.3	0.4	0.8	0.5	0.9	0.6	0.2	-0.7	0.4	0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	2.2	0.4	-0.4	0.6	0.4	1.5	-0.5	-0.3	-0.2	0.0	0.9	1.4	-0.2
Depressed Affect (Nagel 2018)	0.2	0.5	1.2	-0.2	1.0	0.7	-0.3	-0.2	-0.9	0.1	1.0	0.3	-1.1	-0.9	-0.5
Neuroticism (Nagel 2018)	0.2	0.4	1.1	-0.8	0.0	-0.2	-0.4	0.1	-0.7	-1.1	0.2	-0.4	-1.0	-1.0	-0.4
Worry (Nagel 2018)	0.2	0.4	1.3	-0.5	-0.3	-1.0	-0.4	0.7	0.1	-0.4	0.1	-0.1	-1.2	-0.7	0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.0	0.3	-0.0	-0.0	0.8	-0.6	-0.1	0.2	-0.1	0.8	-0.6	0.3
Crohns Disease (2017)	0.2	0.5	2.8	-0.5	-0.3	-1.0	-0.1	-0.1	0.2	-0.3	-0.5	-0.4	1.2	-1.7	0.7
Major Depression (MDD)	0.2	0.3	2.2	-0.2	0.5	-0.3	0.3	0.0	-0.1	0.4	0.6	0.3	0.4	-0.3	1.5
BMI	0.2	1.0	8.7	-0.1	0.4	1.1	-0.4	-3.0	0.6	-0.1	0.2	-0.0	-1.1	0.6	-0.5
Hand grip strength (left)	0.2	0.6	1.5	-0.2	-0.6	-1.2	-1.2	0.6	0.1	-0.7	-0.5	-0.6	1.1	-0.3	1.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.3	-0.1	0.1	-0.6	-0.1	0.3	1.1	-0.2	-0.1	-0.3	1.0	-0.6	0.6
Angina	0.2	0.3	0.8	0.5	-0.1	0.7	-0.2	-0.3	0.6	0.9	0.1	0.4	-0.3	0.8	-0.1
Medication: Co-codamol	0.2	0.3	1.8	-0.6	-0.1	-0.2	-0.2	-1.3	-0.6	0.1	-0.0	0.2	-0.5	0.6	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	-0.5	0.5	-0.3	-0.0	-0.1	-0.8	0.4	0.4	-0.3	-0.8	-0.6	0.6
Alcohol intake versus 10 years previously	0.2	0.3	1.0	0.3	0.5	-0.2	0.1	0.3	-0.2	0.9	0.5	0.1	-1.0	0.1	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.2	0.7	0.2	0.6	0.1	-0.3	-0.4	-0.2	0.8	0.2	-0.2	-0.8	0.9	0.1
Number of live births	0.2	0.3	2.3	-0.4	-0.3	-0.4	0.1	0.2	-1.5	-0.7	-0.3	-0.5	0.2	-0.4	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	0.3	-0.6	-0.0	-0.2	0.5	-0.7	0.4	-0.7	-0.2	1.1	1.0	-0.6
Pulse wave reflection index	0.2	0.2	0.6	-0.3	-0.3	-0.2	0.6	-0.5	0.5	-0.1	-0.2	-0.4	-0.8	-0.8	-0.3
Gout (self-reported)	0.2	0.3	1.8	0.3	0.5	-0.2	0.5	-0.2	-0.3	0.4	0.2	-0.1	0.5	1.3	0.3
Angina (self-reported)	0.2	0.2	0.6	0.1	-0.5	0.5	-0.5	-0.8	0.7	0.6	-0.3	-0.0	-0.6	0.5	-0.3
Comparative height size at age 10	0.2	1.1	3.7	-0.5	-1.1	0.7	-1.3	-1.9	-0.2	-1.2	-0.7	-0.2	0.6	-1.5	-1.2
Suffer from ‘nerves’	0.2	0.3	0.8	-0.5	-0.3	-0.2	-0.8	-0.7	-0.7	-0.5	-0.3	-0.2	0.7	-0.9	0.0
Mood swings	0.2	0.4	1.9	-0.7	0.3	0.1	-0.7	-0.6	-0.9	0.4	0.2	0.0	-1.4	-0.5	-0.5
Eye problems/disorders: Cataract	0.2	0.2	0.8	0.2	-0.7	-0.1	-0.1	0.1	-0.5	-0.9	-0.4	0.1	0.6	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	2.1	0.1	-0.4	0.6	0.8	0.2	0.3	-0.5	-0.4	0.0	1.4	1.0	-1.0
Schizophrenia (2014)	0.1	0.3	1.0	0.2	-0.1	1.0	0.6	-0.0	-0.4	0.2	-0.0	0.2	0.7	0.9	-0.4
Blood Eosinophil Count	0.1	1.0	8.4	0.2	0.9	-0.1	-0.4	-1.1	-0.0	0.9	0.6	0.2	0.4	0.7	2.9
Blood Platelet Count	0.1	1.2	4.7	-0.6	-0.3	-0.7	0.1	-0.7	-2.2	-1.3	-0.8	-0.8	-1.2	-1.1	-1.7
Tanning	0.1	0.9	4.2	-0.4	0.1	0.5	0.5	1.4	1.4	-0.5	-0.4	-0.7	2.0	-0.8	-0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.8	-0.4	0.3	-0.0	-0.9	0.3	-0.0	-0.4	-0.1	-0.3	-0.5	0.4	0.1
Nervous feelings	0.1	0.2	0.7	-0.4	-0.5	0.1	-0.3	0.6	0.8	-0.7	-0.3	-0.2	0.8	-0.5	-0.1
Peak expiratory flow (PEF)	0.1	0.2	0.9	0.7	0.0	-0.1	0.0	0.9	-0.6	-0.3	-0.1	-0.2	-0.6	0.3	-0.6
Comparative body size at age 10	0.1	0.4	1.5	0.1	0.1	1.2	0.0	0.4	-0.2	0.6	0.3	0.6	0.8	0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.9	0.1	0.1	0.6	-1.0	-0.5	-0.4	0.4	0.2	0.3	-0.2	-0.7	0.4
Back pain experienced in last month	0.1	0.2	0.8	-0.1	-0.2	0.4	-0.2	-0.0	-0.1	0.4	-0.1	0.0	0.0	0.8	-0.9
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

SSPN

Models

Trait associations