Hub : Genes

SSPN

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1590	0.0420	5.6e-05	0.065	NA	0.053	NA	0.074	5.5e-06	NA	3.5e-05	NA	1.1e-06
2	GTEx	Artery Aorta	0.1650	0.0630	6.4e-03	-0.001	NA	-0.005	NA	-0.003	3.5e-01	NA	9.0e-01	NA	5.2e-01
3	GTEx	Artery Tibial	0.1726	0.0533	1.1e-03	0.048	NA	0.063	NA	0.060	1.3e-04	NA	1.1e-05	NA	1.6e-05
4	GTEx	Breast Mammary Tissue	0.2690	0.0720	1.5e-04	0.003	NA	0.017	NA	0.018	2.2e-01	NA	4.2e-02	NA	4.1e-02
5	GTEx	Breast Mammary Tissue (Male)	0.2269	0.1527	1.1e-01	-0.013	NA	0.017	NA	-0.013	9.2e-01	NA	1.3e-01	NA	9.7e-01
6	GTEx	Breast Mammary Tissue (Female)	0.1012	0.0904	1.9e-01	-0.005	NA	-0.006	NA	-0.001	4.9e-01	NA	5.4e-01	NA	3.6e-01
7	GTEx	Cells Transformed fibroblasts	0.1430	0.0420	1.5e-04	0.066	NA	0.163	NA	0.136	1.2e-05	NA	3.1e-12	NA	2.1e-10
8	GTEx	Heart Atrial Appendage	0.2680	0.0860	3.4e-03	0.002	NA	0.009	NA	-0.001	2.6e-01	NA	1.2e-01	NA	3.5e-01
9	GTEx	Nerve Tibial	0.1833	0.0592	1.5e-03	0.066	NA	0.056	NA	0.073	1.9e-05	NA	8.4e-05	NA	7.3e-06
10	YFS	Blood	0.0408	0.0151	3.5e-03	0.034	0.009	0.030	0.03	0.036	1.8e-11	3.7e-04	3.0e-10	2.7e-10	5.0e-12
11	TCGA	Liver Hepatocellular Carcinoma	0.1540	0.0600	4.3e-03	0.040	0.066	0.066	NA	0.067	5.8e-03	5.0e-04	5.1e-04	NA	4.6e-04
12	TCGA	Thyroid Carcinoma	0.0800	0.0360	6.8e-04	0.027	0.039	0.040	NA	0.041	1.1e-03	9.5e-05	8.6e-05	NA	7.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.3	0.5	1.4	0.9	0.7	0.8	0.5	1.2	-0.8	0.4	0.8	0.6	0.1	0.3	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.5	2.2	0.4	-0.4	0.6	0.4	1.5	-0.5	-0.3	-0.2	0.0	0.9	1.4	-0.2
Depressed Affect (Nagel 2018)	0.2	0.5	1.2	-0.2	1.0	0.7	-0.3	-0.2	-0.9	0.1	1.0	0.3	-1.1	-0.9	-0.5
Depression (Nagel 2018)	0.6	0.9	3.8	-1.3	-0.7	-0.5	-1.9	-0.8	-0.3	-1.0	-0.9	-1.0	0.4	-0.7	0.5
Intelligence (Savage-Jansen 2018)	0.5	1.4	3.2	1.2	1.1	0.9	1.8	1.1	1.2	0.9	1.2	1.0	-1.5	0.6	-1.3
Neuroticism (Nagel 2018)	0.2	0.4	1.1	-0.8	0.0	-0.2	-0.4	0.1	-0.7	-1.1	0.2	-0.4	-1.0	-1.0	-0.4
Schizophrenia (2018)	0.3	0.6	2.5	-0.2	-1.1	0.2	0.2	0.9	0.1	-0.6	-0.9	-0.4	1.1	1.6	0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.7	0.0	0.2	0.4	0.1	-0.3	-1.1	0.8	-0.1	0.0	-0.9	0.6	1.3
Worry (Nagel 2018)	0.2	0.4	1.3	-0.5	-0.3	-1.0	-0.4	0.7	0.1	-0.4	0.1	-0.1	-1.2	-0.7	0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.0	0.3	-0.0	-0.0	0.8	-0.6	-0.1	0.2	-0.1	0.8	-0.6	0.3
Alzheimer’s Disease (in father)	0.4	0.4	2.1	0.3	0.3	0.1	-0.2	-0.6	-1.4	0.5	0.1	0.5	1.1	-0.7	-0.2
Alzheimer’s Disease (including proxy)	0.3	0.5	2.9	-0.1	0.2	-0.0	-0.2	0.2	-1.0	-0.2	0.1	0.1	1.3	-1.7	0.4
Crohns Disease (2017)	0.2	0.5	2.8	-0.5	-0.3	-1.0	-0.1	-0.1	0.2	-0.3	-0.5	-0.4	1.2	-1.7	0.7
Irritable Bowel Disease (IBD)	0.3	0.7	2.0	-0.7	-0.4	-1.4	0.4	-0.6	-1.2	-0.0	-0.5	-0.9	0.7	-0.9	1.4
Ulcerative Colitis (UC)	0.6	1.1	2.6	-1.1	-1.0	-1.6	0.1	-1.2	-1.6	-0.4	-1.0	-1.4	0.3	-0.4	1.1
Major Depression (MDD)	0.2	0.3	2.2	-0.2	0.5	-0.3	0.3	0.0	-0.1	0.4	0.6	0.3	0.4	-0.3	1.5
Reaction Time	0.3	0.5	4.1	0.4	0.1	-0.7	2.0	0.9	0.1	-0.2	0.1	0.4	0.1	0.0	0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.0	1.2	0.3	1.4	1.0	-0.1	0.2	0.9	0.7	0.9	0.4	0.7	-0.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.5	2.0	4.4	1.5	1.8	1.3	1.0	-0.0	0.4	1.7	1.7	1.7	-1.4	0.4	2.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.4	2.0	4.8	-1.5	-1.6	-1.7	-1.7	0.8	0.8	-0.2	-1.6	-1.5	1.3	-1.0	2.2
Bipolar Disorder (2011)	0.9	0.9	1.7	-1.3	-1.0	-0.4	-0.8	0.1	0.5	-1.0	-1.0	-1.3	0.5	-1.3	-1.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.9	0.8	0.6	1.4	0.6	-0.8	-0.1	0.6	0.5	0.6	-0.8	0.4	-1.0
Coronary Artery Disease (CAD)	0.6	0.7	3.5	-0.6	1.0	-0.7	-0.0	0.4	0.7	0.2	0.4	-0.3	0.0	-1.6	1.9
Crohns Disease (2012)	0.4	0.6	1.8	0.1	0.4	-0.5	0.4	1.2	1.4	-0.4	0.3	-0.1	1.1	-1.3	0.5
Mean Putamen Volume	0.8	0.9	2.2	-1.2	-0.4	-1.1	-0.8	0.4	0.9	-0.7	-0.8	-1.4	-1.5	-0.8	-0.9
Fasting Glucose	1.9	2.3	3.8	1.5	1.8	1.3	1.5	1.0	1.7	1.2	1.9	1.5	-1.9	1.4	-1.1
HbA1C	0.9	1.0	2.4	-1.0	-0.7	-1.5	-1.1	0.8	-1.3	-1.1	-0.7	-0.7	0.6	-1.5	-0.3
HDL Cholesterol	1.5	2.5	6.6	-2.1	-1.3	-0.7	-1.1	-1.4	-0.6	-1.9	-1.7	-1.5	-0.1	-2.6	-2.2
LDL Cholesterol	0.4	0.6	3.1	0.3	1.1	0.4	1.8	-0.3	-0.4	0.5	0.9	0.6	-0.7	-0.6	-0.5
Lupus	0.4	0.6	2.6	-0.9	-1.1	-0.6	-0.8	0.1	-0.2	-1.6	-1.2	-0.3	0.6	0.1	-0.3
Neuroticism (2016)	0.9	1.3	4.7	-2.0	-0.9	-0.3	-0.5	-1.0	-1.4	-0.9	-1.0	-1.1	-0.0	-2.2	-0.4
Primary Biliary Cirrhosis	0.7	1.0	3.5	0.9	1.2	0.2	1.9	1.2	1.1	0.5	1.2	1.0	0.6	-0.5	0.1
Rheumatoid Arthritis	0.4	0.6	3.7	-0.5	-0.2	0.3	0.1	-1.9	0.5	-0.8	-0.3	-0.3	0.0	-0.6	-1.2
Schizophrenia (2014)	0.1	0.3	1.0	0.2	-0.1	1.0	0.6	-0.0	-0.4	0.2	-0.0	0.2	0.7	0.9	-0.4
Triglycerides	1.5	2.4	4.7	1.7	2.1	0.8	2.0	-0.4	1.0	2.0	2.2	1.7	-1.2	1.4	0.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.4	0.2	0.7	-1.0	1.0	1.5	0.3	0.7	0.2	0.1	-0.2	-0.6	1.5
Ulcerative Colitis	0.3	0.5	1.7	0.1	-0.1	-0.4	1.2	-0.4	-0.9	0.0	-0.0	-0.2	1.0	0.3	1.3
Blood Eosinophil Count	0.1	1.0	8.4	0.2	0.9	-0.1	-0.4	-1.1	-0.0	0.9	0.6	0.2	0.4	0.7	2.9
Blood Platelet Count	0.1	1.2	4.7	-0.6	-0.3	-0.7	0.1	-0.7	-2.2	-1.3	-0.8	-0.8	-1.2	-1.1	-1.7
Blood Red Count	0.6	5.8	17.4	2.6	3.0	1.8	2.4	1.0	4.2	2.3	3.0	2.3	-2.1	1.7	0.4
Blood White Count	2.0	14.5	33.4	4.0	4.9	3.0	1.3	1.3	-2.4	5.8	5.0	4.7	-2.4	3.3	4.5
Heel T-Score	1.8	14.6	96.0	2.0	2.5	-3.2	2.6	4.2	3.2	2.9	2.3	1.4	0.7	2.8	9.8
BMI	0.2	1.0	8.7	-0.1	0.4	1.1	-0.4	-3.0	0.6	-0.1	0.2	-0.0	-1.1	0.6	-0.5
Height	0.8	15.4	39.7	-4.4	-3.7	-3.8	-5.1	-3.6	-1.2	-4.4	-3.8	-4.3	1.3	-6.3	-1.6
Waist Hip Ratio (WHR)	6.4	28.9	63.4	6.5	5.0	1.1	5.5	7.5	1.8	6.0	5.3	5.1	0.6	6.0	8.0
Systolic Blood Pressure	1.0	5.2	20.4	1.9	3.3	-1.6	1.1	1.8	0.7	2.0	2.7	1.8	-2.2	0.4	4.5
Smoking Status	0.8	2.0	14.4	-1.1	0.5	-0.4	-0.5	-0.8	-2.0	-0.8	0.2	-0.5	1.2	-3.8	-0.5
Allergy or Eczema	0.5	1.3	4.8	0.8	1.4	-0.2	1.4	-0.4	-1.7	0.9	1.3	0.5	-2.2	0.5	-0.4
Cardiovascular Disease	0.8	2.7	9.0	1.6	3.0	-1.0	2.1	0.4	-0.2	1.8	2.4	1.6	-0.9	0.3	1.5
Hypothyroidism (self reported)	0.8	1.9	5.2	1.5	1.8	0.1	1.7	1.2	0.7	2.3	1.7	0.9	-1.1	0.7	1.4
Respiratory disease	0.3	0.6	1.7	0.8	0.5	0.7	-0.0	-0.3	-0.7	0.9	0.5	0.6	-0.7	1.0	1.3
Type 2 Diabetes (T2D) (2018)	5.0	9.3	14.2	3.5	3.3	2.8	3.7	2.4	-1.1	3.2	3.4	3.1	0.7	3.7	3.8
Lung FEV1/FVC ratio	0.3	1.6	7.6	-1.3	-0.8	-2.8	-1.2	-0.9	-0.1	-1.7	-0.8	-1.2	-0.4	-1.4	-0.4
Lung FVC	0.3	1.4	3.5	-0.5	-1.8	1.3	-0.1	0.5	0.7	-0.1	-1.5	-1.0	1.5	1.2	-1.9
Neuroticism	0.3	0.7	2.8	-0.9	-0.0	0.0	0.2	-0.1	-1.7	-0.7	0.1	-0.5	-1.7	-1.2	-0.5
Chronotype (morning person)	0.3	0.6	3.5	0.7	0.9	0.5	0.3	0.8	0.3	0.3	0.8	0.5	-0.3	0.5	1.9
Hair Pigment	0.3	7.4	24.5	1.5	3.7	0.4	2.2	0.6	-1.6	4.4	3.4	1.8	-5.0	1.6	1.9
Tanning	0.1	0.9	4.2	-0.4	0.1	0.5	0.5	1.4	1.4	-0.5	-0.4	-0.7	2.0	-0.8	-0.7
Hand grip strength (left)	0.2	0.6	1.5	-0.2	-0.6	-1.2	-1.2	0.6	0.1	-0.7	-0.5	-0.6	1.1	-0.3	1.2
Number of treatments/medications taken	0.6	1.1	2.8	1.2	1.2	0.3	0.5	-1.1	0.6	1.1	1.1	1.0	0.1	1.7	1.5
Average weekly spirits intake	1.2	1.5	10.6	1.3	0.2	1.5	0.0	-1.5	0.4	-0.3	0.1	0.8	0.7	0.5	-3.3
Sensitivity / hurt feelings	0.6	1.0	2.1	-1.5	-0.6	-0.5	0.6	-1.3	-0.3	-1.1	-0.7	-1.2	-1.4	-1.4	-1.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.8	-0.4	0.3	-0.0	-0.9	0.3	-0.0	-0.4	-0.1	-0.3	-0.5	0.4	0.1
Hearing difficulty/problems: Yes	0.7	1.0	6.8	0.3	1.0	0.6	0.3	-0.3	0.8	1.1	1.0	0.5	-0.7	-0.5	-2.6
Relative age of first facial hair	1.0	2.0	6.0	1.5	1.8	0.1	1.6	0.6	-0.5	1.6	1.8	1.4	-1.2	0.5	2.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.3	-0.1	0.1	-0.6	-0.1	0.3	1.1	-0.2	-0.1	-0.3	1.0	-0.6	0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.3	0.0	0.5	0.0	1.5	1.3	-0.6	-0.2	0.2	-0.2	-0.3	-0.4	-1.2
Ever had hysterectomy (womb removed)	2.1	2.3	5.6	2.4	1.6	1.8	1.0	0.0	-0.4	1.0	1.8	2.3	0.8	1.7	-1.5
Systolic blood pressure, automated reading	0.6	1.8	8.5	-0.5	0.2	-2.5	-0.9	-0.2	2.0	-0.3	-0.1	-0.6	-0.6	-1.0	2.9
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	3.3	1.6	1.4	1.5	1.1	1.8	0.6	1.6	1.5	1.6	-0.1	1.3	1.3
Angina	0.2	0.3	0.8	0.5	-0.1	0.7	-0.2	-0.3	0.6	0.9	0.1	0.4	-0.3	0.8	-0.1
Medication for hormone replacement therapy	0.3	0.4	3.3	0.1	-0.0	-0.2	0.4	0.1	0.8	0.2	-0.2	-0.2	0.0	0.1	-1.8
Vitamin and mineral supplements	0.9	1.2	4.2	0.9	1.0	0.5	1.7	-0.5	0.2	-0.2	1.0	0.7	2.1	-0.9	1.4
Supplements: Zinc	0.5	0.6	2.1	-0.4	0.9	-1.0	0.1	1.4	-0.5	0.3	0.6	-0.0	-1.3	0.2	0.6
Medication: Co-codamol	0.2	0.3	1.8	-0.6	-0.1	-0.2	-0.2	-1.3	-0.6	0.1	-0.0	0.2	-0.5	0.6	-0.1
Medication: Metformin	6.4	9.0	16.6	3.5	3.2	3.2	2.6	1.4	0.1	4.1	3.5	3.7	0.2	3.5	3.4
Diabetes (father)	1.7	2.1	5.8	1.8	1.4	0.9	1.5	1.6	-0.1	1.6	1.4	1.2	-0.3	2.4	1.7
Diabetes (mother)	3.9	5.0	19.8	2.4	2.0	1.5	1.5	1.0	1.4	2.5	2.1	1.9	-2.9	4.4	0.4
Severe depression (siblings)	0.9	1.0	2.5	-1.0	-1.0	-0.8	-0.7	-0.4	-0.1	-1.4	-1.2	-1.6	1.2	-0.2	-1.1
Pack years adult smoking proportion	0.5	0.8	2.5	0.4	1.2	1.6	0.7	1.0	0.5	1.2	1.0	0.6	-0.5	0.5	0.5
Impedance of leg (right)	1.1	5.1	14.0	-2.6	-2.2	-3.7	-1.6	-0.2	-1.1	-3.2	-2.4	-2.5	2.2	-2.1	1.0
Leg fat-free mass (left)	0.3	1.8	6.4	1.1	1.0	2.5	-0.2	-1.9	-0.8	1.4	1.3	1.3	-1.2	0.3	-1.4
Trunk fat percentage	0.9	3.5	18.7	-2.0	-1.5	-0.9	-2.2	-4.3	-0.1	-1.7	-1.7	-1.6	-0.1	-1.4	-1.1
Hand grip strength (right)	0.5	1.3	2.6	-0.8	-1.1	-1.5	-1.6	1.0	0.1	-1.4	-1.1	-1.2	1.2	-1.0	1.2
Townsend deprivation index at recruitment	0.7	1.0	4.2	0.3	0.8	0.3	0.9	0.2	1.0	0.7	1.0	0.7	-2.0	-0.2	-1.7
Current tobacco smoking	1.5	2.4	7.3	-2.2	-1.0	-0.9	-1.7	-1.0	-2.0	-1.3	-1.2	-1.8	0.1	-2.7	-0.5
Average weekly fortified wine intake	1.1	1.3	4.6	0.6	1.1	0.6	2.1	1.0	2.0	-0.5	1.1	1.1	-0.6	-0.4	-0.8
Maternal smoking around birth	1.8	2.7	9.2	-1.9	-0.5	-2.1	-1.9	-1.3	-1.3	-1.4	-0.9	-1.8	-0.2	-3.0	1.2
Fed-up feelings	0.5	0.8	6.4	-0.2	0.7	1.0	-0.3	-0.4	-2.5	0.2	0.7	0.5	-0.2	-1.0	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.6	-1.6	-1.1	-0.4	-2.1	-1.9	-1.3	-0.9	-1.1	-1.4	0.6	-0.8	0.4
Relative age voice broke	0.7	1.0	4.0	1.6	1.1	0.8	2.0	0.6	-0.5	0.1	1.2	1.2	0.1	0.1	-0.6
Taking other prescription medications	1.2	1.9	5.3	1.6	1.8	1.4	1.4	-0.4	-0.0	2.3	1.4	1.4	0.0	1.5	1.1
Age when periods started (menarche)	1.0	2.5	4.5	-1.4	-2.1	-2.1	-1.6	-0.6	-1.4	-1.7	-2.0	-1.7	1.0	-1.1	1.3
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	5.7	2.1	1.5	2.4	1.6	0.3	0.4	1.1	1.5	2.0	1.0	1.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	11.8	0.6	1.4	-1.3	1.0	2.0	-0.4	0.7	1.1	0.5	0.3	1.4	3.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.3	0.9	1.4	0.5	0.2	0.1	-0.1	0.4	1.3	0.6	-1.5	-0.7	-1.2
Qualifications: CSEs or equivalent	0.3	0.4	3.1	0.2	0.0	0.1	0.6	0.5	-0.3	-0.3	-0.1	-0.2	-0.7	0.2	-1.8
Serious illness, injury or assault to yourself	0.3	0.4	2.1	0.0	0.1	0.4	0.3	1.1	-1.4	0.2	0.3	-0.0	0.6	-0.3	-0.8
High blood pressure	0.5	1.3	4.1	-0.2	1.4	-2.0	-0.1	-0.7	0.1	0.8	1.0	0.0	-1.9	-0.2	1.9
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.2	1.3	1.4	0.4	1.8	0.7	-1.4	0.8	1.3	0.9	-1.7	0.7	-0.7
Multivitamins +/- minerals	0.4	0.5	1.1	-0.8	-0.9	-1.0	-0.4	0.8	0.4	-0.2	-1.0	-0.8	-0.1	0.5	-0.5
Stomach or abdominal pain in last month	0.4	0.5	1.5	0.7	0.7	0.6	0.8	0.8	-0.9	0.6	0.7	0.4	0.6	1.2	0.5
Supplements: Glucosamine	0.6	0.8	3.9	-0.5	-0.4	0.6	-0.5	-2.0	1.3	-0.2	-0.2	-0.5	1.5	0.5	-0.9
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.9	-0.9	-1.3	0.0	-1.4	-1.6	-0.9	-1.7	-1.1	-1.0	0.1	-0.3	-0.5
Medication: Atenolol	0.5	0.6	1.5	1.0	0.9	0.4	1.2	-0.3	-0.2	0.6	0.9	0.9	0.0	1.1	1.0
Medication: Levothyroxine sodium	0.7	1.2	3.1	0.6	1.2	-0.9	1.7	1.4	1.4	1.0	1.0	0.1	-1.8	-0.3	-0.3
Sitting height	0.4	2.9	11.2	-0.5	-0.9	1.9	-2.5	-2.1	-3.3	-1.1	-0.8	-0.4	1.6	-0.8	-1.8
Chronic bronchitis/emphysema (father)	2.5	3.0	5.7	1.8	1.8	0.8	1.9	1.5	2.4	1.9	1.9	1.7	-2.3	0.8	0.8
High blood pressure (mother)	0.3	0.4	1.7	0.3	0.7	-0.1	0.6	-0.9	-0.0	-0.1	0.5	0.4	-1.3	0.4	-0.8
Body mass index (BMI)	0.4	1.8	8.0	0.7	1.2	2.0	0.0	-2.8	0.2	1.4	1.2	1.0	-1.4	1.1	-0.7
Impedance of leg (left)	1.0	4.7	14.0	-2.4	-2.2	-3.7	-1.4	0.4	-0.7	-2.9	-2.4	-2.6	1.7	-1.7	1.2
Leg predicted mass (left)	0.3	1.8	6.2	1.1	1.0	2.5	-0.2	-1.9	-0.8	1.4	1.3	1.3	-1.1	0.2	-1.3
Trunk fat mass	0.5	2.2	16.7	-1.2	-0.8	0.2	-1.8	-4.1	-0.4	-0.7	-0.9	-0.8	-0.2	-0.7	-1.0
Waist circumference	0.7	2.7	5.6	1.9	2.1	1.9	1.0	-0.8	-0.1	2.4	2.1	1.9	-0.5	2.0	1.2
Number of incorrect matches in round	0.3	0.6	1.5	0.8	0.2	1.2	0.1	-0.4	1.2	0.8	0.4	1.1	0.3	1.0	0.4
Past tobacco smoking	0.5	0.9	5.4	-0.2	-1.4	0.1	-1.1	0.0	0.5	-0.5	-0.9	-0.4	-1.0	2.3	-0.1
Alcohol usually taken with meals	0.8	1.3	5.2	1.3	0.8	0.3	-0.0	2.2	0.8	0.8	1.0	1.1	0.2	-0.1	2.3
Nervous feelings	0.1	0.2	0.7	-0.4	-0.5	0.1	-0.3	0.6	0.8	-0.7	-0.3	-0.2	0.8	-0.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	-0.5	0.5	-0.3	-0.0	-0.1	-0.8	0.4	0.4	-0.3	-0.8	-0.6	0.6
Hearing difficulty/problems with background noise	1.0	1.6	6.9	-1.3	-0.4	-0.8	-0.0	-0.7	1.2	-0.6	-0.6	-1.2	-2.1	-1.3	-2.6
Hair/balding pattern: Pattern 2	2.0	2.6	22.5	0.2	1.0	-0.8	0.0	0.4	-1.5	1.3	1.0	0.8	-1.1	0.0	4.7
Had menopause	2.0	2.5	5.2	-2.2	-1.5	-1.6	-0.2	-1.7	2.1	-1.5	-1.5	-1.7	0.3	-2.3	-0.1
Had other major operations	0.6	0.8	3.6	-0.7	-0.6	-0.9	-1.2	-0.8	-1.1	0.3	-0.6	-0.5	-0.0	-0.3	1.9
Forced vital capacity (FVC)	0.6	2.5	6.9	-1.4	-2.6	-0.6	-1.2	1.0	-0.0	-1.9	-2.4	-2.1	1.8	-0.7	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	8.4	0.8	1.3	-0.9	0.9	1.9	-0.6	0.7	1.0	0.5	0.3	1.5	2.9
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	6.8	0.7	0.7	0.2	0.0	-0.0	-1.0	0.5	0.8	1.0	1.6	0.9	2.6
Qualifications: None of the above	1.4	3.0	4.8	-2.2	-1.6	-1.2	-1.5	-2.0	2.1	-2.0	-1.6	-1.6	0.2	-2.0	-2.0
Financial difficulties in last 2 years	1.3	1.7	7.4	-1.4	-0.6	0.4	-1.6	-1.9	-2.7	-0.9	-0.8	-1.0	0.6	-1.1	-0.6
Mouth/teeth dental problems	2.3	3.6	8.2	-2.2	-1.5	-1.4	-2.2	-2.0	-1.4	-1.4	-1.4	-1.5	0.4	-2.8	2.9
Heart attack	0.4	0.6	2.5	0.0	-0.3	0.6	0.2	0.9	1.1	0.7	-0.2	-0.2	-0.3	1.6	-1.1
Allergy	0.3	0.8	3.0	-1.1	-0.9	0.0	-0.9	-0.3	1.7	-0.7	-0.8	-0.5	1.2	-0.9	-0.1
Pain all over the body in last month	1.0	1.0	6.7	0.2	0.9	0.5	-0.4	-0.8	-2.6	1.3	0.7	0.2	-0.5	0.6	0.9
Diabetes (self-reported)	5.3	8.2	15.1	3.3	3.1	2.6	2.3	1.5	-1.4	3.9	3.3	3.1	-0.5	3.8	3.4
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	5.8	1.1	0.1	0.6	1.2	0.3	-1.0	-0.3	0.0	0.5	2.4	-0.2	1.3
Medication: Ramipril	1.0	1.3	4.2	0.9	0.8	0.6	-0.2	-0.4	-0.6	2.1	0.7	1.1	-1.2	1.6	1.9
Medication: Simvastatin	0.4	0.6	3.4	0.3	0.3	-1.2	-0.3	0.6	-0.2	0.2	0.3	0.2	-0.7	1.2	1.8
Fluid intelligence score	0.6	1.3	3.7	1.7	1.0	1.6	1.9	1.3	0.4	1.0	1.0	1.1	0.0	0.6	-0.4
Illnesses of siblings	0.5	0.7	2.1	-0.5	-0.6	0.6	-1.1	-0.8	-0.0	-1.1	-0.3	-0.5	1.4	-0.9	-1.3
Neuroticism score	0.4	0.8	1.8	-1.0	0.1	0.1	0.3	-0.7	-1.2	-1.0	0.0	-0.5	-1.2	-1.4	-1.3
Weight	0.3	1.4	10.8	-0.1	0.2	1.3	-1.3	-3.3	-1.0	0.4	0.3	0.2	-0.6	-0.3	-0.9
Impedance of arm (right)	1.9	8.9	16.9	-3.5	-3.6	-4.1	-2.9	-1.0	-1.5	-3.4	-3.7	-3.2	2.8	-3.2	0.9
Arm fat percentage (right)	0.4	1.4	14.5	-0.6	-0.1	0.6	-1.1	-3.8	-0.2	0.2	-0.2	-0.2	-0.7	0.0	-0.4
Trunk fat-free mass	0.5	2.7	8.3	2.1	1.7	2.9	0.2	-1.1	-1.5	2.2	2.0	2.0	-0.5	1.0	-0.3
Hip circumference	1.0	4.3	22.2	-1.9	-0.8	0.6	-2.3	-4.7	-1.6	-1.5	-1.0	-1.1	-0.3	-2.0	-3.0
Time employed in main current job	1.1	1.2	2.3	-1.0	-0.8	-1.0	-1.4	-0.7	-0.5	-1.5	-1.0	-0.9	1.5	-1.3	1.2
Alcohol intake versus 10 years previously	0.2	0.3	1.0	0.3	0.5	-0.2	0.1	0.3	-0.2	0.9	0.5	0.1	-1.0	0.1	1.0
Father’s age at death	1.5	2.1	8.3	1.6	1.1	1.7	1.2	2.9	0.6	1.2	1.1	1.2	1.3	1.0	1.2
Worrier / anxious feelings	0.7	1.2	3.9	-1.6	-1.2	-2.0	-1.0	-0.5	-0.3	-1.1	-1.1	-1.4	-0.4	-1.0	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.2	0.7	0.2	0.6	0.1	-0.3	-0.4	-0.2	0.8	0.2	-0.2	-0.8	0.9	0.1
Falls in the last year	0.4	0.6	3.7	0.1	-1.0	-0.0	-0.0	-0.7	0.9	-1.9	-0.7	0.3	0.7	-0.1	-0.4
Hair/balding pattern: Pattern 3	3.6	5.4	43.4	-0.4	-1.1	0.6	-0.1	-1.9	1.4	-2.6	-1.3	-1.0	1.9	-1.0	-6.6
Number of live births	0.2	0.3	2.3	-0.4	-0.3	-0.4	0.1	0.2	-1.5	-0.7	-0.3	-0.5	0.2	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.0	-1.3	-2.2	-1.2	-1.4	0.8	-0.3	-1.8	-2.1	-1.9	1.7	-0.5	-0.6
Pulse rate	3.3	5.6	13.4	-2.3	-3.5	-2.7	-3.7	-0.9	-0.2	-2.4	-3.4	-2.3	1.6	-1.2	1.2
Happiness	0.9	1.0	3.8	-1.1	-0.2	-1.2	-0.8	0.7	-0.9	-0.6	-0.3	-1.0	-1.9	-1.5	0.7
Noisy workplace	0.5	0.6	3.1	-1.0	-0.0	-0.8	-0.2	-0.1	-0.8	-1.1	-0.1	-0.2	1.8	-0.8	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	0.3	-0.6	-0.0	-0.2	0.5	-0.7	0.4	-0.7	-0.2	1.1	1.0	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	4.2	0.6	0.8	0.9	0.4	0.3	-1.3	0.8	0.7	0.6	-0.2	0.3	-2.0
Mouth/teeth dental problems: Dentures	0.5	0.9	4.0	1.2	0.3	0.4	0.9	0.8	0.4	0.5	0.4	0.2	-0.3	1.6	-2.0
Asthma	0.4	0.8	3.7	0.9	0.8	0.2	0.0	-1.1	-0.6	0.9	0.5	0.6	-0.5	1.0	1.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	4.8	0.1	-0.1	1.1	0.6	-0.0	0.3	-0.5	0.0	-0.1	0.3	0.8	-2.2
Medication: Cholesterol lowering	0.6	1.0	4.1	1.0	0.5	0.4	0.2	0.5	1.1	1.0	0.4	0.9	0.8	1.4	2.0
Depression (self-reported)	0.7	0.8	2.0	-0.2	-1.1	-0.4	-1.3	-1.4	-1.0	-1.3	-1.1	-0.4	0.7	-0.2	0.0
Medication: Lansoprazole	0.5	0.5	2.2	0.3	0.4	0.4	0.0	-0.2	-0.2	1.5	0.5	0.5	-1.3	1.1	0.3
Prospective memory result	0.4	0.4	1.3	-0.1	-0.9	-0.6	-0.7	-0.6	1.1	0.4	-0.5	-0.2	-0.8	0.8	-0.3
Lung cancer (father)	3.2	3.8	8.0	-2.5	-2.6	-2.1	-2.3	-0.9	0.8	-2.0	-2.4	-2.8	1.0	-1.5	0.7
Illnesses of mother	0.8	1.0	2.9	-0.9	-1.7	-0.4	-1.0	-0.6	-1.0	-1.2	-1.2	-0.9	1.0	0.3	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.8	-0.8	-1.6	-0.8	-1.0	0.6	0.9	-1.2	-1.4	-1.1	1.7	-0.4	-0.5
Pulse wave Arterial Stiffness index	0.3	0.4	1.5	-0.2	-0.7	-0.3	-0.2	-1.2	-0.5	-0.2	-0.4	-0.4	0.9	-0.9	-0.0
Impedance of arm (left)	2.5	11.8	21.1	-4.1	-4.4	-4.3	-3.5	-1.3	-0.7	-4.2	-4.6	-4.0	2.9	-3.0	0.1
Arm fat mass (right)	0.3	1.3	11.7	-0.3	0.2	1.1	-0.9	-3.4	-0.2	0.6	0.2	0.1	-0.9	0.1	-0.5
Trunk predicted mass	0.5	2.8	8.4	2.1	1.7	2.9	0.4	-1.0	-1.4	2.1	2.1	2.0	-0.4	1.0	-0.2
Standing height	0.4	4.3	9.9	-1.7	-2.4	-1.6	-3.1	-1.4	-2.3	-2.1	-2.1	-1.8	1.9	-2.9	-0.2
Length of working week for main job	0.5	0.5	2.4	-0.3	-0.8	-0.7	0.2	1.5	1.1	-0.5	-0.6	-0.6	-0.5	-0.6	-0.3
Exposure to tobacco smoke at home	1.0	1.1	3.3	-1.5	-1.1	-0.4	-1.4	-1.8	0.4	-0.6	-1.2	-1.2	0.4	-0.8	-0.6
Breastfed as a baby	1.8	2.2	4.8	-1.6	-1.8	-2.2	-1.1	-0.2	1.6	-1.4	-1.7	-1.4	0.4	-0.7	2.1
Tense / ‘highly strung’	0.5	0.8	2.7	-0.7	-0.8	-0.6	0.1	0.4	-0.8	-1.3	-0.6	-0.6	-0.9	-1.3	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	6.1	-0.6	-0.7	-0.5	-0.6	-1.7	-2.5	-0.4	-0.7	-0.5	0.1	-0.5	-0.3
Hair/balding pattern: Pattern 4	4.3	10.5	85.2	-0.3	0.2	2.0	2.5	0.8	1.8	-3.0	0.0	-0.2	3.1	-2.7	-9.2
Birth weight of first child	0.8	1.4	2.3	1.0	1.3	1.0	1.4	1.5	0.7	0.6	1.4	1.0	-1.3	1.1	-1.3
Peak expiratory flow (PEF)	0.1	0.2	0.9	0.7	0.0	-0.1	0.0	0.9	-0.6	-0.3	-0.1	-0.2	-0.6	0.3	-0.6
Pulse wave reflection index	0.2	0.2	0.6	-0.3	-0.3	-0.2	0.6	-0.5	0.5	-0.1	-0.2	-0.4	-0.8	-0.8	-0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	3.9	-1.1	0.0	-0.6	0.3	0.6	-0.0	-0.4	-0.2	-0.7	0.4	-2.0	-0.5
Loud music exposure frequency	0.7	0.8	3.1	0.7	0.5	0.1	-0.3	0.4	-1.8	0.9	0.7	0.8	0.8	1.1	1.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	4.1	1.0	-0.5	0.6	0.4	2.0	-0.2	0.1	-0.5	0.4	1.4	2.0	0.1
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	6.6	0.4	0.9	1.0	0.9	-0.3	0.8	0.3	0.8	1.0	-0.3	0.7	-2.6
Blood clot in the leg (DVT)	0.3	0.4	2.3	0.3	-0.4	-0.2	0.7	0.3	0.9	-0.1	-0.1	-0.1	-0.9	-0.3	-1.5
Medication: Paracetamol	0.7	1.2	3.8	-0.5	-0.4	0.6	-1.5	-1.5	-2.0	0.3	-0.4	-0.5	-1.2	1.7	-0.3
Headache pain in last month	0.3	0.6	1.9	-0.6	-0.9	-0.2	-0.6	-0.4	0.1	-1.0	-1.1	-0.8	1.4	-0.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.4	-0.9	-0.9	-0.0	-0.3	0.2	-0.1	-1.0	-0.7	-0.7	-0.2	-0.5	-1.5
Glaucoma (self-reported)	0.6	0.7	3.7	0.0	-0.7	-0.5	0.1	0.1	-1.1	-1.5	-0.5	0.1	1.9	0.2	0.3
Gout (self-reported)	0.2	0.3	1.8	0.3	0.5	-0.2	0.5	-0.2	-0.3	0.4	0.2	-0.1	0.5	1.3	0.3
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	4.5	1.2	1.9	-0.1	1.9	1.7	1.2	2.1	1.7	0.7	-1.3	0.8	1.1
Medication: Amlodipine	0.9	1.3	3.4	0.8	1.8	-0.4	0.8	-0.8	-0.3	1.6	1.6	1.0	-1.7	0.3	0.8
Medication: Ventolin 100micrograms inhaler	1.1	1.5	8.0	-0.8	0.2	-1.5	-1.0	-1.7	-0.5	0.4	-0.2	-0.3	-0.6	-1.4	2.8
Birth weight	0.9	1.9	6.2	-1.1	-1.3	-2.5	-2.1	0.9	1.2	-1.4	-1.3	-1.4	-0.2	-1.0	-0.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	4.7	-0.4	-0.4	-0.6	-0.5	0.3	2.2	-0.5	-0.7	-0.7	1.5	-0.9	0.0
High blood pressure (siblings)	0.7	1.0	5.2	0.6	1.6	-0.2	2.3	0.2	0.4	0.0	1.2	0.7	0.1	-1.3	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.5	4.5	-0.9	-1.9	0.0	-1.0	0.5	1.0	-1.3	-1.7	-1.2	2.1	-0.3	-0.9
Body fat percentage	0.7	2.7	18.6	-1.6	-1.0	-0.5	-1.8	-4.3	-0.2	-1.2	-1.2	-1.2	-0.3	-0.9	-0.8
Leg fat percentage (right)	0.4	1.5	14.0	-0.8	-0.2	0.4	-1.1	-3.7	-0.3	-0.7	-0.3	-0.6	-0.2	-0.1	-0.8
Arm fat-free mass (right)	0.5	2.4	7.9	1.6	1.7	2.8	0.4	-1.3	-0.7	1.7	1.9	1.7	-1.3	0.9	-1.2
Exposure to tobacco smoke outside home	0.7	1.0	4.3	1.1	-0.6	1.6	0.1	0.8	0.7	0.6	0.0	0.8	0.9	2.1	-0.4
Comparative body size at age 10	0.1	0.4	1.5	0.1	0.1	1.2	0.0	0.4	-0.2	0.6	0.3	0.6	0.8	0.9	-0.7
Number of full brothers	1.3	1.6	4.9	-1.5	-1.1	-1.1	-1.5	-2.2	-0.8	-1.2	-1.3	-0.8	0.6	-1.3	1.1
Worry too long after embarrassment	0.4	0.6	1.6	-0.7	-0.2	0.0	1.0	1.0	-0.7	-1.3	-0.3	-0.7	-0.4	-1.0	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.7	-1.6	-1.3	-1.4	-1.2	0.5	-1.4	-1.0	-1.3	-1.6	-0.8	0.1	0.8
Wheeze or whistling in the chest in last year	0.6	1.1	2.7	-0.7	-0.6	-1.6	-1.7	-1.2	-1.6	-0.1	-1.0	-0.8	-0.5	-0.1	1.2
Number of children fathered	0.6	0.7	4.5	0.3	-0.2	1.2	0.6	-0.1	0.6	-0.5	-0.3	-0.2	1.0	0.5	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	2.6	0.0	-0.4	0.0	-0.6	-0.4	-0.2	0.3	-0.4	0.3	0.6	1.6	-0.2
Age at first live birth	0.7	1.3	3.6	1.1	0.3	0.8	-0.3	1.3	1.6	0.3	0.6	1.2	1.9	1.4	1.3
Pulse wave peak to peak time	0.3	0.3	1.7	0.2	0.6	0.2	-0.0	1.3	0.3	0.2	0.4	0.4	-0.9	0.7	0.2
Health satisfaction	0.4	0.5	1.8	0.4	1.2	0.3	0.3	-0.7	-1.3	0.6	1.1	0.5	-0.5	0.1	-0.4
Shortness of breath walking on level ground	0.5	0.6	2.3	0.2	0.6	0.8	-0.0	-1.4	-0.5	-0.1	0.3	0.8	1.5	-0.4	-0.3
Qualifications: College or University degree	0.4	1.3	3.0	1.7	1.1	0.5	0.5	-0.1	-1.3	1.2	1.0	1.4	-0.0	1.7	1.7
Eye problems/disorders: None of the above	0.7	0.8	3.6	-0.4	0.1	-0.3	-0.5	-0.3	1.7	0.2	-0.1	-0.6	-0.7	-1.1	-1.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.5	1.1	0.6	1.2	0.2	0.9	-0.4	0.9	0.8	1.1	1.1	1.2	0.5
Emphysema/chronic bronchitis	0.6	0.7	2.7	-0.8	-1.3	0.1	-1.6	-1.2	0.4	-0.1	-1.1	-0.6	-0.6	-0.1	-0.2
Medication for pain relief, constipation, heartburn	0.5	0.9	4.2	-0.0	0.5	-1.2	1.2	1.8	-0.5	-0.1	0.4	-0.0	-0.0	-2.1	0.1
Neck or shoulder pain in last month	1.3	1.8	4.7	-1.9	-1.5	-1.5	-1.5	-2.2	0.2	-1.1	-1.5	-1.6	-0.6	0.7	-0.1
Medication: Blood pressure	0.4	0.6	4.0	0.5	1.0	-0.4	0.1	-0.0	-0.0	0.9	0.7	0.5	0.0	0.5	2.0
Angina (self-reported)	0.2	0.2	0.6	0.1	-0.5	0.5	-0.5	-0.8	0.7	0.6	-0.3	-0.0	-0.6	0.5	-0.3
Migraine (self-reported)	2.4	3.0	10.2	-1.7	-2.3	-0.3	-3.2	-2.4	-1.4	-1.4	-2.1	-1.5	1.3	-0.3	0.3
Medication: Ibuprofen	0.4	0.4	2.1	-0.0	-0.3	1.0	0.2	-0.0	0.5	-0.3	-0.2	-0.4	0.1	1.1	-1.5
Medication: Allopurinol	0.7	0.9	4.1	1.0	1.3	0.3	1.1	-0.1	-0.3	0.8	1.2	0.6	-0.3	2.0	-0.4
Medication: Omeprazole	0.4	0.5	1.9	0.1	1.0	0.3	-0.2	-1.4	-0.0	0.4	0.6	0.4	-1.3	0.1	-0.9
Medication: Seretide 50 evohaler	0.4	0.5	2.1	0.2	-0.1	0.4	-1.5	-1.2	-0.5	0.1	-0.0	0.6	-1.1	0.3	0.6
Mean time to correctly identify matches	0.4	0.7	5.9	0.5	0.2	-0.7	2.4	0.4	0.8	-0.3	0.3	0.5	-0.2	-0.1	0.9
Heart disease (mother)	0.5	0.7	2.9	-0.5	0.5	-1.1	0.2	0.2	0.2	-0.2	0.1	-0.3	-1.0	-1.7	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.0	-0.2	-0.5	-1.0	-0.7	0.3	0.0	0.2	-0.5	-0.6	-0.4	0.4	0.9
Whole body fat mass	0.4	1.7	16.1	-0.7	-0.3	0.7	-1.4	-4.0	-0.4	-0.4	-0.4	-0.4	-0.2	-0.4	-0.7
Leg fat mass (right)	0.4	1.5	13.8	-0.2	0.4	1.3	-0.7	-3.7	-0.6	0.1	0.4	0.1	-0.8	-0.1	-0.9
Arm predicted mass (right)	0.5	2.5	8.0	1.8	1.8	2.8	0.5	-1.3	-0.6	1.9	2.0	1.8	-1.1	1.1	-0.8
Pulse rate, automated reading	8.3	26.8	64.2	-5.6	-7.3	-5.7	-8.0	-2.7	-0.9	-5.7	-7.1	-5.8	2.2	-3.0	0.8
Alcohol intake frequency.	0.5	1.2	3.8	1.0	0.9	0.7	0.3	0.8	0.8	1.2	1.3	1.3	-0.4	1.9	1.2
Comparative height size at age 10	0.2	1.1	3.7	-0.5	-1.1	0.7	-1.3	-1.9	-0.2	-1.2	-0.7	-0.2	0.6	-1.5	-1.2
Number of full sisters	0.5	0.6	3.0	-0.5	-0.6	-0.9	-0.7	-0.2	0.2	-0.6	-0.5	-0.5	-1.7	-0.8	0.1
Suffer from ‘nerves’	0.2	0.3	0.8	-0.5	-0.3	-0.2	-0.8	-0.7	-0.7	-0.5	-0.3	-0.2	0.7	-0.9	0.0
Overall health rating	0.3	0.7	3.1	-0.4	0.1	0.6	-0.8	-1.1	-1.8	-0.1	-0.0	-0.3	1.1	0.3	1.0
Chest pain or discomfort	0.4	0.6	4.2	-0.4	-0.5	-0.7	0.5	2.1	0.1	-0.1	-0.5	-0.6	0.1	0.7	0.6
Had major operations	0.3	0.4	0.7	-0.7	-0.6	-0.8	0.0	0.7	-0.6	-0.7	-0.4	-0.8	-0.6	-0.4	-0.8
Age at last live birth	1.4	2.1	4.0	2.0	0.9	1.5	1.1	1.8	1.7	1.4	1.2	1.8	1.0	1.6	0.5
Family relationship satisfaction	0.5	0.6	3.3	-0.3	-0.2	-0.3	-0.6	0.2	-1.3	0.4	-0.0	0.1	-1.0	0.4	1.8
Leg pain on walking	0.3	0.3	1.3	-0.1	0.5	0.1	-0.2	-1.1	-1.1	0.6	0.5	0.4	-0.5	0.3	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	11.8	-0.9	-0.5	-0.5	-0.5	-0.0	-3.4	0.3	-0.3	-0.8	-1.2	-0.1	0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.4	0.8	0.6	0.5	1.5	0.9	0.4	0.4	0.6	0.4	-0.9	0.0	-0.9
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	5.8	-0.8	-1.0	-2.4	-0.7	0.1	2.4	-1.0	-1.0	-1.1	-0.2	-0.4	1.8
Medication: Aspirin	0.9	1.2	4.4	0.8	-0.2	1.0	-0.5	-0.1	1.9	1.2	0.1	0.6	-0.1	2.1	1.4
Supplements: Vitamin C	1.2	1.4	5.8	-1.4	-1.4	-0.6	-2.4	-0.2	-0.4	-0.3	-1.2	-0.9	-1.8	0.3	-0.9
Knee pain experienced in last month	1.7	2.6	9.3	-1.8	-1.6	-0.5	-2.1	-3.1	-1.4	-1.6	-1.5	-1.4	0.5	-1.1	-1.1
Hypertension (Self-reported)	0.5	1.4	4.5	0.2	1.7	-1.7	0.4	-0.4	0.0	1.4	1.3	0.3	-1.7	0.3	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.5	-0.5	0.0	-0.8	-1.1	-1.6	0.8	0.9	-0.3	-0.3	-0.0	0.2	1.0
Illnesses of father: Heart disease	0.6	0.8	2.9	0.4	1.0	-0.1	0.1	0.9	1.5	0.7	0.7	0.6	-1.7	-0.5	-0.9
Illnesses of siblings: Diabetes	2.1	2.6	10.7	1.2	0.8	0.4	1.0	0.3	-0.9	1.9	1.0	1.2	-2.1	2.5	3.3
Smoking status: Previous	0.7	1.0	3.3	0.9	1.6	0.2	1.8	0.0	-0.2	0.8	1.2	0.9	0.9	-1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.9	0.1	0.1	0.6	-1.0	-0.5	-0.4	0.4	0.2	0.3	-0.2	-0.7	0.4
Whole body fat-free mass	0.4	2.5	8.4	1.7	1.5	2.9	0.2	-1.5	-1.3	2.0	1.9	1.8	-0.9	0.7	-0.7
Leg fat-free mass (right)	0.3	1.8	6.7	1.2	1.0	2.6	-0.1	-1.4	-0.7	1.7	1.3	1.3	-1.3	0.5	-1.2
Arm fat percentage (left)	0.4	1.5	14.8	-0.7	-0.3	0.7	-1.2	-3.9	0.0	0.0	-0.4	-0.3	-0.6	0.2	-0.6
Average weekly red wine intake	0.4	0.6	3.6	0.5	-0.0	1.4	0.6	0.0	-0.4	-0.6	0.1	0.5	1.9	-0.7	0.2
Handedness (chirality/laterality): Left-handed	1.2	1.5	3.2	1.6	1.6	1.2	0.1	0.2	0.3	1.8	1.6	1.7	-1.2	1.0	-0.0
Mood swings	0.2	0.4	1.9	-0.7	0.3	0.1	-0.7	-0.6	-0.9	0.4	0.2	0.0	-1.4	-0.5	-0.5
Loneliness, isolation	0.3	0.4	1.9	-0.7	0.9	0.2	0.0	-0.5	-1.2	-0.2	0.5	-0.1	-0.2	-1.4	0.2
Long-standing illness, disability or infirmity	2.2	3.4	8.0	2.0	2.4	1.4	2.8	1.0	-1.1	2.1	2.1	1.9	0.1	2.1	0.6
Ever had bowel cancer screening	2.3	2.7	5.0	-2.1	-1.9	-1.4	-1.3	-0.5	-1.8	-1.7	-1.9	-2.1	0.7	-2.2	-0.5
Diabetes diagnosed by doctor	6.4	10.5	17.4	3.7	3.3	3.2	3.1	2.6	-1.2	4.0	3.5	3.5	0.0	4.2	4.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.7	-1.0	-0.9	-0.4	-1.6	-0.7	0.5	-1.5	-0.9	-0.9	0.7	-1.0	-0.1
Friendships satisfaction	0.7	0.9	2.6	0.7	1.0	0.6	0.0	0.8	-1.6	1.0	1.3	0.8	-1.2	0.2	1.0
Qualifications: nursing, teaching	0.5	0.7	4.6	0.9	-0.1	-0.3	0.8	-0.1	1.2	0.7	0.0	0.5	-0.1	2.1	-0.5
Commuting to job workplace: Walk	0.6	0.6	1.5	-1.1	-0.7	-0.0	-0.0	-0.8	-0.7	-1.2	-1.1	-1.1	0.2	-0.3	-0.7
Eye problems/disorders: Cataract	0.2	0.2	0.8	0.2	-0.7	-0.1	-0.1	0.1	-0.5	-0.9	-0.4	0.1	0.6	0.4	0.5
Mouth/teeth dental problems: Mouth ulcers	3.7	5.9	12.6	2.9	2.1	1.8	3.5	2.6	2.6	2.2	2.2	2.3	-0.3	3.1	-1.8
Medication for cholesterol	1.0	1.6	2.8	-1.5	-1.7	-0.1	-1.2	-0.2	-0.1	-1.6	-1.7	-1.5	1.4	-0.9	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.5	-0.6	-0.2	-0.4	-0.8	-1.6	1.2	0.3	-0.2	-0.4	-0.8	1.0	1.6
Back pain experienced in last month	0.1	0.2	0.8	-0.1	-0.2	0.4	-0.2	-0.0	-0.1	0.4	-0.1	0.0	0.0	0.8	-0.9
Mineral and other dietary supplements	1.3	1.7	4.0	1.4	2.0	1.0	1.5	0.9	-0.4	1.5	1.9	1.7	-0.6	-0.7	0.8
Breast cancer (self-reported)	2.0	2.4	12.6	-1.0	-1.6	-0.1	-1.8	-1.2	-1.0	-1.4	-1.5	-0.8	3.5	-0.3	1.6
Asthma (self-reported)	0.3	0.6	3.0	0.7	0.5	-0.1	-0.1	-0.9	-0.2	0.7	0.2	0.3	-0.7	1.0	1.7
Osteoporosis (self-reported)	0.9	1.2	7.7	-0.6	-0.9	0.4	-0.5	0.2	-1.0	-1.5	-0.6	-0.6	0.4	-0.6	-2.8
Osteoarthritis (self-reported)	0.8	1.0	4.1	0.3	1.5	0.7	0.8	0.3	1.7	0.0	0.9	0.4	2.0	0.3	-0.3
Medication: Aspirin	1.3	1.6	5.2	1.2	0.1	1.3	-0.2	-0.1	2.1	1.3	0.4	1.1	0.5	2.3	1.9
Medication: Gliclazide	5.1	5.7	17.4	2.9	2.5	1.9	2.5	2.1	0.4	2.3	2.2	2.3	1.7	2.1	4.2
Illnesses of father: None of the above (group 1)	1.6	1.9	12.2	-0.3	-1.2	1.1	0.2	-0.1	-1.7	-1.8	-1.1	-0.6	3.5	-0.6	-0.4
Smoking status: Current	1.5	2.3	7.3	-2.1	-1.1	-1.1	-1.7	-0.8	-1.9	-1.4	-1.3	-1.7	0.4	-2.7	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	2.1	0.1	-0.4	0.6	0.8	0.2	0.3	-0.5	-0.4	0.0	1.4	1.0	-1.0
Whole body water mass	0.4	2.5	8.6	1.7	1.6	2.9	0.2	-1.5	-1.2	2.0	1.9	1.8	-0.8	0.6	-0.8
Leg predicted mass (right)	0.3	1.8	6.8	1.2	1.0	2.6	-0.0	-1.4	-0.7	1.7	1.3	1.3	-1.3	0.5	-1.2
Arm fat mass (left)	0.3	1.4	13.4	-0.2	0.2	1.3	-1.1	-3.7	0.0	0.4	0.2	0.2	-0.7	0.2	-0.4
Number of self-reported non-cancer illnesses	0.7	1.3	5.1	1.4	1.1	0.4	1.5	-0.5	0.2	1.2	0.9	0.9	0.3	2.3	1.3
Average weekly champagne plus white wine intake	0.4	0.5	1.1	-0.6	-1.0	-0.9	-0.6	-0.1	0.7	0.5	-0.9	-1.1	0.8	-0.4	-0.2
Miserableness	0.3	0.5	1.1	0.0	1.0	0.6	0.5	-0.4	-0.9	0.5	0.9	0.4	-0.9	-0.1	-1.0
Guilty feelings	0.7	1.1	5.5	-0.4	0.2	0.6	1.2	1.0	-0.1	-1.6	-0.1	-0.4	1.3	-0.6	-2.4
Wears glasses or contact lenses	1.5	1.7	3.2	-1.6	-1.4	-1.2	-0.7	-1.6	-0.5	-1.3	-1.8	-1.5	1.8	-0.9	0.0
Ever taken oral contraceptive pill	2.0	2.2	6.1	1.4	2.2	2.5	1.6	-0.1	0.8	1.4	2.0	1.6	1.2	-0.4	0.3
Hearing aid user	2.2	2.5	4.5	-1.9	-1.5	-1.7	-2.1	-1.6	-0.7	-0.8	-1.6	-1.8	1.6	-2.0	0.1
Mother’s age at death	0.6	0.8	3.9	0.5	1.3	-0.1	2.0	0.5	0.2	0.4	1.1	0.3	-0.7	-0.3	-0.7
Financial situation satisfaction	1.1	1.3	3.8	1.3	0.9	1.1	1.9	2.0	0.2	1.1	1.1	1.0	-0.4	0.5	-1.1
Tinnitus: Yes, now most or all of the time	4.0	4.7	9.4	-3.1	-2.4	-2.0	-2.1	-1.9	0.0	-2.7	-2.6	-2.8	0.1	-1.9	-2.1
Commuting to job workplace: Public transport	0.3	0.4	1.1	0.3	0.9	-0.1	0.4	-0.4	-1.1	1.0	0.7	0.4	-0.7	0.7	0.3
Eye problems/disorders: Glaucoma	1.0	1.1	5.7	-0.4	-0.9	-0.1	-0.2	-0.3	-1.6	-1.5	-0.8	-0.1	2.4	-0.9	0.8
Medication: Blood pressure	2.1	4.0	8.3	1.8	2.7	0.1	1.5	-0.2	0.1	2.7	2.9	2.3	-2.5	0.8	2.7
Pain type(s) experienced in last month: Hip pain	1.7	2.2	7.3	-1.5	-0.8	-1.3	-2.0	-2.7	-2.0	-0.7	-1.1	-0.8	1.1	-1.4	1.0
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.3	-1.5	-1.7	-1.3	-1.3	-0.1	0.2	-2.1	-1.8	-1.5	0.5	-0.2	-0.1
High cholesterol (Self-reported)	0.5	0.8	1.6	1.2	0.7	-0.5	1.2	0.4	1.1	0.7	0.7	1.0	-0.2	1.1	1.3
Medication: Bendroflumethiazide	0.7	1.1	4.6	0.1	1.7	-0.7	0.9	-0.1	1.1	0.9	1.5	0.2	-2.1	-0.7	0.5
Medication: Paracetamol	1.0	1.5	6.2	-1.2	-1.0	-0.3	-1.7	-1.5	-2.5	-0.3	-0.9	-1.1	-1.3	0.9	0.1
Medication: Lisinopril	0.8	1.0	2.7	0.8	1.6	-0.4	1.5	0.9	0.7	0.8	1.6	0.8	-1.0	0.3	0.0
Medication: Atorvastatin	2.5	3.0	6.8	2.5	1.6	2.0	1.7	0.4	0.1	1.9	1.8	2.6	0.7	2.4	0.7
Illnesses of father: High blood pressure	1.8	2.3	8.6	0.7	1.1	0.0	-0.5	-0.9	-1.4	2.9	1.2	1.1	-2.2	1.5	1.9
Alcohol drinker status: Never	1.0	1.2	3.8	0.5	-1.0	-1.1	-0.1	1.9	1.9	-0.3	-0.4	-0.1	-1.0	1.9	0.6
Ever smoked	0.6	1.0	6.9	-0.1	1.1	-0.1	1.0	0.4	-1.0	0.3	0.8	0.0	0.8	-2.6	-0.5
Basal metabolic rate	0.3	1.9	6.2	1.2	1.2	2.5	-0.3	-2.0	-1.2	1.6	1.5	1.4	-0.9	0.4	-0.9
Leg fat percentage (left)	0.3	1.1	10.0	-0.6	-0.1	0.3	-1.0	-3.2	-0.0	-0.4	-0.3	-0.5	-0.6	0.2	-0.4
Arm fat-free mass (left)	0.5	2.4	6.5	1.6	1.9	2.5	0.3	-1.5	-1.0	1.9	2.1	1.8	-1.2	0.6	-0.8
Number of operations (self-reported)	0.4	0.6	1.8	0.4	0.1	1.0	0.2	-0.9	-1.3	0.4	-0.0	0.1	0.5	0.8	-1.3
Average weekly beer plus cider intake	0.4	0.6	3.2	-0.3	-0.7	-0.1	-0.3	1.1	-0.8	0.2	-0.5	-0.7	-0.5	1.0	-1.8
Irritability	2.0	3.4	9.1	-2.5	-1.3	-1.7	-2.0	-1.8	-0.5	-2.1	-1.7	-2.3	-0.5	-3.0	-0.5
Risk taking	0.4	0.5	2.1	-0.6	0.2	-0.4	-0.6	-0.5	-1.2	-0.1	0.1	-0.5	-1.5	-1.0	-0.5
Ever had prostate specific antigen (PSA) test	1.2	1.4	4.0	-0.6	-1.2	-0.3	-0.6	-1.9	-1.9	-1.1	-1.1	-0.7	2.0	-0.9	0.1
Fractured/broken bones in last 5 years	0.3	0.4	2.1	-0.7	-0.1	-0.2	0.0	0.1	0.7	0.4	-0.1	-0.6	-1.4	0.3	-1.2
Age started oral contraceptive pill	1.3	1.6	4.2	-1.6	-2.1	-0.9	-1.2	-0.5	1.5	-1.4	-1.5	-1.1	0.7	-0.1	1.1
Diastolic blood pressure, automated reading	0.7	2.1	12.3	-0.0	0.5	-2.4	-0.8	0.4	2.1	0.2	0.4	0.1	-1.1	-0.8	3.5
Ever depressed for a whole week	0.8	1.0	7.4	-0.7	-0.9	-0.3	-0.3	-0.4	-0.8	-1.0	-0.7	-0.7	2.7	-0.4	0.6
Unable to work because of sickness or disability	2.4	3.1	8.1	2.2	1.7	2.8	1.0	1.3	-1.2	1.9	1.7	2.2	1.1	2.1	1.0
Commuting to job workplace: Cycle	0.3	0.4	1.9	0.6	0.5	0.3	-0.1	0.6	0.7	0.6	0.3	0.1	-0.6	0.7	-1.4
Myopia	1.6	2.3	5.8	1.6	1.2	2.4	0.6	-0.4	-1.0	2.2	1.3	2.0	-1.1	2.0	-0.4
Vascular/heart problems diagnosed by doctor	0.4	1.2	5.2	0.6	-0.8	2.3	0.5	0.9	-0.7	-0.4	-0.5	0.3	2.0	0.4	-1.4
Cholesterol lowering medication	0.9	1.3	2.6	1.1	1.4	-0.4	0.9	0.1	-0.6	1.2	1.4	1.2	-1.4	1.2	1.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.4	0.2	1.1	0.6	0.1	-0.9	0.4	0.7	0.6	0.7	-1.2	0.3	-0.8
Pain experienced in last month	0.4	0.6	4.0	0.1	-0.6	-0.4	0.4	2.0	1.2	-0.5	-0.4	-0.2	-0.1	-0.1	1.1
Supplements: Calcium	0.9	1.0	2.3	-1.5	-1.2	-1.1	-1.2	0.8	-0.8	-0.8	-1.4	-1.3	-0.0	-0.7	-0.2
Basal cell carcinoma (self-reported)	0.9	1.0	2.3	-1.3	-1.3	-0.1	-1.3	-1.4	-1.5	0.4	-1.1	-1.2	-0.1	0.2	0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.2	0.0	-0.3	0.7	0.1	0.7	0.9	0.7	-0.2	-0.1	-0.2	1.5	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	3.2	0.6	0.1	0.1	1.0	0.6	0.9	0.1	0.3	0.3	-1.1	-0.2	-1.8
Heart disease (siblings)	0.6	0.7	2.0	-0.5	-0.9	-0.9	-0.3	0.9	-0.8	-0.1	-1.1	-0.6	-1.4	1.0	0.9
Alcohol drinker status: Previous	1.5	1.7	3.4	0.9	1.4	1.5	1.9	0.7	1.5	1.7	1.4	0.9	-1.2	1.1	-0.7
Pack years of smoking	0.3	0.4	1.6	0.1	0.7	1.3	0.4	0.8	0.5	0.9	0.6	0.2	-0.7	0.4	0.3
Impedance of whole body	1.8	9.2	19.4	-3.7	-3.6	-4.4	-2.7	-0.6	-0.8	-3.9	-3.8	-3.5	2.4	-3.0	0.3
Leg fat mass (left)	0.4	1.4	12.2	-0.1	0.4	1.3	-0.7	-3.5	-0.4	0.3	0.4	0.1	-1.1	0.2	-0.8
Arm predicted mass (left)	0.5	2.8	7.8	1.8	2.0	2.8	0.4	-1.6	-1.0	1.9	2.3	2.0	-1.0	0.5	-0.8