Best TWAS P=1.88e-35 · Best GWAS P=4.01e-65 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | ALG10 | 0.06 | 0.04 | lasso | 6 | 0.02 | 3.5e-02 | 11.9 | -12.4 | 1.9e-35 | -0.60 | 0.46 | 0.27 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | ALG10 | 0.05 | 0.04 | lasso | 2 | 0.04 | 5.6e-04 | 10.3 | -10.6 | 2.2e-26 | -0.55 | 0.88 | 0.02 | FALSE |
| 3 | GTEx | Nerve Tibial | ALG10 | 0.08 | 0.04 | lasso | 8 | 0.04 | 9.7e-04 | 11.4 | -7.9 | 2.9e-15 | -0.41 | 0.43 | 0.29 | TRUE |
| 4 | METSIM | Adipose | ALG10 | 0.05 | 0.04 | blup | 224 | 0.05 | 4.2e-08 | 14.5 | -8.6 | 1.1e-17 | -0.40 | 0.98 | 0.02 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | SYT10 | 0.18 | 0.04 | enet | 25 | 0.12 | 1.4e-14 | -5.0 | 6.4 | 1.4e-10 | 0.30 | 1.00 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ALG10 | 0.02 | 0.02 | enet | 3 | 0.02 | 8.0e-05 | 9.3 | -7.9 | 2.5e-15 | -0.50 | 0.40 | 0.05 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ALG10 | 0.07 | 0.07 | blup | 26 | 0.07 | 1.1e-08 | 9.3 | -7.9 | 2.7e-15 | -0.44 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ALG10 | 0.11 | 0.06 | enet | 8 | 0.08 | 4.1e-05 | 9.4 | -7.5 | 5.0e-14 | -0.45 | 0.24 | 0.09 | TRUE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ALG10 | 0.06 | 0.04 | blup | 26 | 0.05 | 3.0e-06 | 9.5 | -10.7 | 7.8e-27 | -0.63 | 0.02 | 0.97 | TRUE |
| 10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ALG10 | 0.12 | -0.01 | blup | 26 | 0.02 | 8.9e-02 | 9.5 | -10.2 | 2.9e-24 | -0.60 | 0.02 | 0.32 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | ALG10 | 0.13 | 0.04 | lasso | 1 | 0.04 | 1.4e-04 | 9.4 | -9.4 | 8.2e-21 | -0.54 | 0.43 | 0.10 | FALSE |