Best TWAS P=1.16e-11 · Best GWAS P=1.61e-08 conditioned to 0.0994
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | TUBA1A | 0.08 | 0.06 | lasso | 4 | 0.06 | 1.8e-07 | -5.0 | 5.3 | 1.1e-07 | -0.68 | 0.06 | 0.94 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | TUBA1C | 0.41 | 0.54 | lasso | 5 | 0.54 | 3.0e-77 | -5.2 | -5.2 | 1.7e-07 | 0.71 | 0.06 | 0.94 | FALSE |
3 | GTEx | Adipose Subcutaneous | LMBR1L | 0.12 | 0.09 | lasso | 6 | 0.08 | 1.9e-07 | -5.3 | 6.3 | 4.0e-10 | -0.66 | 0.02 | 0.98 | FALSE |
4 | GTEx | Adipose Visceral Omentum | LMBR1L | 0.09 | 0.03 | lasso | 6 | 0.01 | 7.4e-02 | -5.6 | 5.5 | 2.9e-08 | -0.71 | 0.02 | 0.91 | FALSE |
5 | GTEx | Artery Aorta | RP11-302B13.1 | 0.16 | 0.04 | enet | 13 | 0.08 | 2.9e-05 | -3.5 | 6.0 | 1.5e-09 | -0.49 | 0.04 | 0.89 | FALSE |
6 | GTEx | Artery Aorta | RP11-302B13.5 | 0.13 | 0.07 | lasso | 6 | 0.06 | 2.0e-04 | -5.5 | 6.8 | 1.2e-11 | -0.65 | 0.02 | 0.95 | TRUE |
7 | GTEx | Artery Tibial | CCDC65 | 0.14 | 0.08 | enet | 39 | 0.11 | 7.9e-09 | -3.8 | -5.6 | 2.9e-08 | 0.46 | 0.83 | 0.14 | FALSE |
8 | GTEx | Brain Cerebellum | LMBR1L | 0.18 | 0.15 | lasso | 1 | 0.12 | 1.9e-04 | -5.3 | 5.3 | 1.2e-07 | -0.68 | 0.02 | 0.92 | FALSE |
9 | GTEx | Esophagus Muscularis | TUBA1B | 0.08 | 0.04 | lasso | 7 | 0.06 | 1.9e-04 | -5.1 | 5.2 | 1.6e-07 | -0.75 | 0.04 | 0.89 | FALSE |
10 | GTEx | Esophagus Muscularis | RP11-386G11.10 | 0.10 | 0.11 | lasso | 7 | 0.10 | 1.0e-06 | -5.1 | 5.2 | 1.8e-07 | -0.74 | 0.05 | 0.94 | FALSE |
11 | GTEx | Nerve Tibial | RP11-386G11.10 | 0.07 | 0.05 | lasso | 2 | 0.03 | 1.8e-03 | -5.3 | 5.3 | 1.2e-07 | -0.68 | 0.02 | 0.95 | FALSE |
12 | GTEx | Pituitary | RP11-386G11.10 | 0.19 | 0.11 | lasso | 5 | 0.10 | 1.4e-03 | -5.6 | 5.7 | 9.3e-09 | -0.94 | 0.03 | 0.78 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | LMBR1L | 0.15 | 0.10 | lasso | 3 | 0.09 | 3.1e-08 | -5.3 | 5.3 | 1.1e-07 | -0.68 | 0.02 | 0.98 | FALSE |
14 | GTEx | Spleen | LMBR1L | 0.30 | 0.30 | enet | 11 | 0.30 | 2.4e-08 | -5.6 | 5.3 | 8.8e-08 | -0.62 | 0.01 | 0.98 | FALSE |
15 | GTEx | Testis | TUBA1B | 0.21 | 0.28 | lasso | 9 | 0.26 | 7.0e-12 | -5.3 | 5.4 | 6.7e-08 | -0.70 | 0.03 | 0.97 | FALSE |
16 | GTEx | Testis | LMBR1L | 0.13 | 0.11 | lasso | 3 | 0.12 | 4.1e-06 | -5.1 | 5.4 | 7.8e-08 | -0.72 | 0.02 | 0.98 | FALSE |
17 | GTEx | Testis | RP11-386G11.10 | 0.25 | 0.33 | lasso | 9 | 0.32 | 1.3e-14 | -5.3 | 5.4 | 7.6e-08 | -0.70 | 0.03 | 0.97 | FALSE |
18 | GTEx | Thyroid | LMBR1L | 0.12 | 0.10 | lasso | 3 | 0.10 | 6.4e-08 | -5.3 | 5.3 | 1.0e-07 | -0.68 | 0.02 | 0.98 | FALSE |
19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TUBA1C | 0.12 | 0.10 | lasso | 4 | 0.10 | 1.2e-11 | -5.1 | -5.2 | 1.5e-07 | 0.72 | 0.02 | 0.98 | FALSE |